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<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q326P8</accession>
    <name>Q326P8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS3 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406198.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326P8"/>
    <dbReference type="EnsemblBacteria" id="ABB64710">
        <property type="protein sequence ID" value="ABB64710"/>
        <property type="gene ID" value="SDY_P197"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P197"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5749"/>
    <dbReference type="HOGENOM" id="CLU_027402_18_2_6"/>
    <dbReference type="OMA" id="SWRSIRR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8062" checksum="A326978AF545568A" modified="2005-12-06" version="1">MTKTVSTSKKTRKQHSPEFCSEALKLAERIGVAAAARELSLYESQLYAWRSKLQQQMTSSERKSELAAENAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Q6</accession>
    <name>Q326Q6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spa32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spa32</name>
        <name evidence="2" type="ordered locus">SDY_P189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001162452.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406190.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Q6"/>
    <dbReference type="EnsemblBacteria" id="ABB64702">
        <property type="protein sequence ID" value="ABB64702"/>
        <property type="gene ID" value="SDY_P189"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P189"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5740"/>
    <dbReference type="HOGENOM" id="CLU_952818_0_0_6"/>
    <dbReference type="OMA" id="NESGNAD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="292" mass="33051" checksum="8070BC4B0D0768CA" modified="2005-12-06" version="1">MALDNINLNFSSDKQIEKCEKLSSIDNIDSLVLKKKRKVEIPEYSLIASNYFTIDKHFEHKHDKGEIYSGIKNAFELRNERATYSDILESMVIKENILIPVQDIKAREKINIGDMRGIFSYNESGNADKNFERSHTSSANPDNLLEPDNRNSQIGLKNHSLSIDKNIADIISLLNGSVAKSFDLPVMKKNTSDITPSMSLQEKSIVENDKNVYQKNSEMTYHFKQWGAGHSVSISVESGSFVLKPSDQFVGNKLDLILKQDAEGNYRFDSSQHNKGNKNNSTGYNEQSEEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q326U0</accession>
    <name>Q326U0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS1353 putative transposase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406156.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326U0"/>
    <dbReference type="EnsemblBacteria" id="ABB64668">
        <property type="protein sequence ID" value="ABB64668"/>
        <property type="gene ID" value="SDY_P155"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P155"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5711"/>
    <dbReference type="HOGENOM" id="CLU_027402_41_1_6"/>
    <dbReference type="OMA" id="MYEGYIN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="117" mass="13167" checksum="728197E260CEE163" modified="2005-12-06" version="1">MVDCFDGKVVSGSLSTRPDAELVNTMLDNAVGTLNAGERPVIHSDRGGHYRWPGWLERVNAAGLIRSMSRKGCSPDNAACEGFFGRLKTEMYYGRKWSGITPEKFMQQVDAYIRWYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q326X5</accession>
    <name>Q326X5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid maintenance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mvpT</name>
        <name evidence="3" type="ordered locus">SDY_P120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000450529.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406121.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326X5"/>
    <dbReference type="EnsemblBacteria" id="ABB64633">
        <property type="protein sequence ID" value="ABB64633"/>
        <property type="gene ID" value="SDY_P120"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P120"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5675"/>
    <dbReference type="HOGENOM" id="CLU_162018_3_2_6"/>
    <dbReference type="OMA" id="VFTNNRS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8594" checksum="F3CB61D4DF765B23" modified="2005-12-06" version="1">METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHSVSADFMDNREQPDMQERESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q327X3</accession>
    <name>Q327X3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjcB</name>
        <name evidence="2" type="ordered locus">SDY_4507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327X3"/>
    <dbReference type="STRING" id="300267.SDY_4507"/>
    <dbReference type="EnsemblBacteria" id="ABB64382">
        <property type="protein sequence ID" value="ABB64382"/>
        <property type="gene ID" value="SDY_4507"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4507"/>
    <dbReference type="HOGENOM" id="CLU_173116_0_0_6"/>
    <dbReference type="OMA" id="NIQFRKS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016958">
        <property type="entry name" value="UCP030798"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15940">
        <property type="entry name" value="YjcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030798">
        <property type="entry name" value="UCP030798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="116" mass="13020" checksum="43889EE4FD673D9F" modified="2005-12-06" version="1">MYHASREQRRAVQGIGSFQRNCLMATLTTGVVLLRWQLLSAVMMFLANTLNIRFRRSDYVGLAVISSGLGVVSACWFAMGLLGITMADITAIWHNIESVMIEEMNQTPPQWPMILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q328A1</accession>
    <name>Q328A1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">evgS</name>
        <name evidence="14" type="ordered locus">SDY_4478</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378966.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405845.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328A1"/>
    <dbReference type="STRING" id="300267.SDY_4478"/>
    <dbReference type="EnsemblBacteria" id="ABB64354">
        <property type="protein sequence ID" value="ABB64354"/>
        <property type="gene ID" value="SDY_4478"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4478"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5288"/>
    <dbReference type="HOGENOM" id="CLU_000445_37_3_6"/>
    <dbReference type="OMA" id="NFGKHEA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220942" description="Histidine kinase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="718"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="960"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="13">
        <location>
            <begin position="1098"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="1009"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="8">
        <location>
            <position position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB64354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1197" mass="134951" checksum="6B5CD2869B2F49A6" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q328C3</accession>
    <name>Q328C3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjeI</name>
        <name evidence="1" type="ordered locus">SDY_4450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405823.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328C3"/>
    <dbReference type="STRING" id="300267.SDY_4450"/>
    <dbReference type="EnsemblBacteria" id="ABB64332">
        <property type="protein sequence ID" value="ABB64332"/>
        <property type="gene ID" value="SDY_4450"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4450"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5249"/>
    <dbReference type="HOGENOM" id="CLU_128258_2_0_6"/>
    <dbReference type="OMA" id="QNFWSSF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025294">
        <property type="entry name" value="DUF4156"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13698">
        <property type="entry name" value="DUF4156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="128" mass="13065" checksum="EA877E6DC3A29FD3" modified="2005-12-06" version="1">MASSSLIMGNNMHVKYLAGIVGAALLMAGCSSSNELSAAGQSVRIVDEQPGAECQLIGTATGKQSNWLSGQHGEEGGSMRGAANDLRNQAAAMGGNVIYGISSPSQGMLSSFVPTDSQIIGQVYKCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q328F5</accession>
    <name>Q328F5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjeT</name>
        <name evidence="2" type="ordered locus">SDY_4413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001089295.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405791.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328F5"/>
    <dbReference type="STRING" id="300267.SDY_4413"/>
    <dbReference type="EnsemblBacteria" id="ABB64300">
        <property type="protein sequence ID" value="ABB64300"/>
        <property type="gene ID" value="SDY_4413"/>
    </dbReference>
    <dbReference type="GeneID" id="66671911"/>
    <dbReference type="KEGG" id="sdy:SDY_4413"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5211"/>
    <dbReference type="HOGENOM" id="CLU_179416_0_0_6"/>
    <dbReference type="OMA" id="APNGWRN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019201">
        <property type="entry name" value="DUF2065"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38602">
        <property type="entry name" value="PTHR38602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09838">
        <property type="entry name" value="DUF2065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="65" mass="7166" checksum="4E50EAC6C4925D5D" modified="2005-12-06" version="1">MNSTIWLALALVLVLEGLGPMLYPKAWKKMISAMTNLPDNILRRFGGGLVVAGVVVYYMLRKTIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q328F7</accession>
    <name>NSRR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional repressor NsrR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nsrR</name>
        <name type="ordered locus">SDY_4411</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001177639.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405789.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328F7"/>
    <dbReference type="SMR" id="Q328F7"/>
    <dbReference type="STRING" id="300267.SDY_4411"/>
    <dbReference type="EnsemblBacteria" id="ABB64298">
        <property type="protein sequence ID" value="ABB64298"/>
        <property type="gene ID" value="SDY_4411"/>
    </dbReference>
    <dbReference type="GeneID" id="67414796"/>
    <dbReference type="KEGG" id="sdy:SDY_4411"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5209"/>
    <dbReference type="HOGENOM" id="CLU_107144_2_1_6"/>
    <dbReference type="OMA" id="AQEAFYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01177">
        <property type="entry name" value="HTH_type_NsrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023761">
        <property type="entry name" value="Tscrpt_rep_HTH_NsrR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000268949" description="HTH-type transcriptional repressor NsrR">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="HTH rrf2-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01177"/>
        </source>
    </evidence>
    <sequence length="141" mass="15593" checksum="6A783840023134D7" modified="2005-12-06" version="1">MQLTSFTDYGLRALIYMASLPEGRMTSISEVTDVYGVSRNHMVKIINQLSRAGYVTAVRGKNGGIRLGKPASAIRIGDVVRELEPLSLVNCSSEFCHITPACRLKQALSKAVQSFLTELDNYTLADLVEENQPLYKLLLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q328R4</accession>
    <name>Q328R4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding component of citrate-dependent iron(III) transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fecE</name>
        <name evidence="5" type="ordered locus">SDY_4293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000175449.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405682.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328R4"/>
    <dbReference type="STRING" id="300267.SDY_4293"/>
    <dbReference type="EnsemblBacteria" id="ABB64191">
        <property type="protein sequence ID" value="ABB64191"/>
        <property type="gene ID" value="SDY_4293"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4293"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5061"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_6"/>
    <dbReference type="OMA" id="SHQVELM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="255" mass="28218" checksum="C97851BA91D51A7F" modified="2005-12-06" version="1">MTLRTENLKVSYGTDKVLNDVSLSLPTGKITALIGPNGCGKSTLLNCFSRLLMPQSGTVFLGDNPINMLSSRQLARRLSLLPQHHLTPEGITVQELVSYGRNPWLSLWGRLSAEDNARVNVAMNQTRINHLAVRRLTELSGGQRQRAFLAMVLAQNTPVVLLDEPTTYLDINHQVDLMRLMGELRTQGKTVVAVLHDLNQASRYCDQLVVMANGHVMAQGTPEEVMTPGLLRTVFSVEAEIHPEPVSGRPMCLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q328V8</accession>
    <name>Q328V8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_4246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405638.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328V8"/>
    <dbReference type="EnsemblBacteria" id="ABB64147">
        <property type="protein sequence ID" value="ABB64147"/>
        <property type="gene ID" value="SDY_4246"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4246"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5006"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="VIWMADG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="15002" checksum="2067607D6C774B57" modified="2005-12-06" version="1">MDEQWEYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Y1</accession>
    <name>Q328Y1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjbE</name>
        <name evidence="3" type="ordered locus">SDY_4222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000757333.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405615.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Y1"/>
    <dbReference type="STRING" id="300267.SDY_4222"/>
    <dbReference type="EnsemblBacteria" id="ABB64124">
        <property type="protein sequence ID" value="ABB64124"/>
        <property type="gene ID" value="SDY_4222"/>
    </dbReference>
    <dbReference type="GeneID" id="67414681"/>
    <dbReference type="KEGG" id="sdy:SDY_4222"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4971"/>
    <dbReference type="HOGENOM" id="CLU_171058_2_0_6"/>
    <dbReference type="OMA" id="CAAPVET"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025858">
        <property type="entry name" value="YjbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11106">
        <property type="entry name" value="YjbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220677" evidence="2">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="80" mass="7386" checksum="A34F87939E466272" modified="2005-12-06" version="1">MKKVLYGIFAISALAATSAWAAPVQVGEAAGSAATSVSAGSSSATSVSTVSSAVGVALAATGGGDGSNTGTTTTTTTSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q329F5</accession>
    <name>Q329F5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_4140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405541.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329F5"/>
    <dbReference type="EnsemblBacteria" id="ABB64050">
        <property type="protein sequence ID" value="ABB64050"/>
        <property type="gene ID" value="SDY_4140"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4140"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4867"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14978" checksum="EACE7ACCC76FE056" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVFAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q329T5</accession>
    <name>RAVA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase RavA</fullName>
            <ecNumber evidence="1">3.6.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Regulatory ATPase variant A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ravA</name>
        <name type="ordered locus">SDY_4002</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RavA family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63920" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63920.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016794.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405411.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329T5"/>
    <dbReference type="SMR" id="Q329T5"/>
    <dbReference type="STRING" id="300267.SDY_4002"/>
    <dbReference type="EnsemblBacteria" id="ABB63920">
        <property type="protein sequence ID" value="ABB63920"/>
        <property type="gene ID" value="SDY_4002"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4002"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4714"/>
    <dbReference type="HOGENOM" id="CLU_018678_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01625">
        <property type="entry name" value="ATPase_RavA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023671">
        <property type="entry name" value="ATPase_RavA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022547">
        <property type="entry name" value="ATPase_RavA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045427">
        <property type="entry name" value="MoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041538">
        <property type="entry name" value="RavA-like_AAA_lid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17868">
        <property type="entry name" value="AAA_lid_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20030">
        <property type="entry name" value="bpMoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12592">
        <property type="entry name" value="DUF3763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000209379" description="ATPase RavA">
        <location>
            <begin position="1"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="498" mass="56496" checksum="24D4D6A749969C81" modified="2006-01-10" version="2">MAHPHLLAERISRLSSSLEKGLYERSHAIRLCLLAALSGESMFLLGPPGIAKSLIARRLKFAFQNARAFEYLMTRFSTPEEVFGPLSIQALKDEGRYERLTSGYLPEAEIVFLDEIWKAGPAILNTLLTAINERQFRNGAHVEKIPMRLLVAASNELPEADSSLEALYDRMLIRLWLDKVQDKANFRSMLTSQQDENDNPVPDALQVTDEEYERWQKEIGEITLPDHVFELIFMLRQQLDKLPDAPYVSDRRWKKAIRLLQASAFFSGRSAVAPVDLILLKDCLWYDAQSLNLIQQQIDVLMTGHAWQQQGMLTRLGAIVQRHLQLQQQQSDKTALTVIRLGGIFSRRQQYQLPVNVTASTLTLLLQKPLKLHDMEVVHISFERSALEQWLSKGGEIRGKLNGIGFAQKLNLEVDSAQHLVVRDVSLQGSTLALPGSSAESMPGKIKQQLEELESDWRKQHALFSEQQRCLFIPGDWLGRIEASLQDVGAQIRQAQQC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q329X1</accession>
    <name>WECF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.325</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-alpha-L-fucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">TDP-Fuc4NAc:lipid II Fuc4NAc transferase</fullName>
            <shortName evidence="1">Fuc4NAc transferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">wecF</name>
        <name evidence="1" type="synonym">rffT</name>
        <name type="ordered locus">SDY_3955</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-ManNAcA-(1-&gt;4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose = alpha-D-FucNAc4-(1-&gt;4)-beta-D-ManNAcA-(1-&gt;4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28759"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:61495"/>
            <dbReference type="ChEBI" id="CHEBI:61496"/>
            <dbReference type="ChEBI" id="CHEBI:68493"/>
            <dbReference type="EC" id="2.4.1.325"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 56 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.325" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000217226.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405375.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329X1"/>
    <dbReference type="SMR" id="Q329X1"/>
    <dbReference type="STRING" id="300267.SDY_3955"/>
    <dbReference type="CAZy" id="GT56">
        <property type="family name" value="Glycosyltransferase Family 56"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63884">
        <property type="protein sequence ID" value="ABB63884"/>
        <property type="gene ID" value="SDY_3955"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3955"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4666"/>
    <dbReference type="HOGENOM" id="CLU_066584_0_0_6"/>
    <dbReference type="OMA" id="VIVPMGY"/>
    <dbReference type="UniPathway" id="UPA00566"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102031">
        <property type="term" value="F:4-acetamido-4,6-dideoxy-D-galactose transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009246">
        <property type="term" value="P:enterobacterial common antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036065">
        <property type="term" value="P:fucosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01002">
        <property type="entry name" value="WecF_RffT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009993">
        <property type="entry name" value="WecF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07429">
        <property type="entry name" value="Glyco_transf_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000062747" description="TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01002"/>
        </source>
    </evidence>
    <sequence length="359" mass="40553" checksum="9AA31A4CB1B27BBE" modified="2005-12-06" version="1">MTVLIHVLGSDIPHHNRTVLRFFNDALAATSEHAREFMVVGKDDGLSDSCPALSVQFFPGKKSLAEAVIAKAKANRQQRFFFHGQFNPKLWLALLSGGIKSRQFFWHIWGADLYELSSGLIYKLFYPLRRLAQKRVGCVFATRGDLSFFAKTHPKVRGELLYFPTRMDPSLNTLANDRQREGKMTILVGNSGDRSNEHVAALRAVHQQFGDTVKVVVPMGYPPNNEAYIEEVRQAGLELFSEENLQVLSEKLEFDAYLALLRQCDLGYFIFARQQGIGTLCLLIQAGIPCVLNRENPFWQDMTEQHLPVLFTTDDLNEDIVREAQRQLASVDKNTIAFFSPNYLQGWQRALAIAAGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Y3</accession>
    <name>Q329Y3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405363.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Y3"/>
    <dbReference type="EnsemblBacteria" id="ABB63873">
        <property type="protein sequence ID" value="ABB63873"/>
        <property type="gene ID" value="SDY_3939"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3939"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4649"/>
    <dbReference type="HOGENOM" id="CLU_139046_0_0_6"/>
    <dbReference type="OMA" id="FKGNGQH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016498">
        <property type="entry name" value="YzcX"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006864">
        <property type="entry name" value="UCP006864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="161" mass="17347" checksum="50F90929999E619C" modified="2005-12-06" version="1">MVAALFGCQPYLVQRFLAVDNDFAAILKGNGQHAAVDFAVDIAVAIPVVQTLFNGQPQLISQAMKFTVVHCCILFLSDGGSIAAWGQGFKVCPSAAAFRHDSSVTGIMMSLCSERFVSSLGRSYTTPFPVSGKHYDQVYRASILTLTELKKPTNKPHCDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A02</accession>
    <name>Q32A02_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yigK</name>
        <name evidence="6" type="ordered locus">SDY_3919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A02"/>
    <dbReference type="STRING" id="300267.SDY_3919"/>
    <dbReference type="EnsemblBacteria" id="ABB63853">
        <property type="protein sequence ID" value="ABB63853"/>
        <property type="gene ID" value="SDY_3919"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3919"/>
    <dbReference type="HOGENOM" id="CLU_079569_2_1_6"/>
    <dbReference type="OMA" id="NPKYYLF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="138" mass="15370" checksum="AD81A660818DEA1B" modified="2005-12-06" version="1">MIAFEVLKWAGAAYLIWLGIQQWRAAGAIDLKSLASTQSRRHLFQRAVFVNLTNPKSIVFLAALFPQFIMPQQPQLMQYIVLGVTTIVVDIIVMIGYATLAQRIALWIKGPKQMKALNKIFGSLFMLVGALLASARHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A04</accession>
    <name>Q32A04_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000285365.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405342.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A04"/>
    <dbReference type="STRING" id="300267.SDY_3917"/>
    <dbReference type="EnsemblBacteria" id="ABB63851">
        <property type="protein sequence ID" value="ABB63851"/>
        <property type="gene ID" value="SDY_3917"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3917"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4625"/>
    <dbReference type="HOGENOM" id="CLU_044146_5_2_6"/>
    <dbReference type="OMA" id="CCAERGI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="266" mass="29639" checksum="3179E2B5813D9602" modified="2005-12-06" version="1">MYQVVASDLDGTLLSPDHTLSPYAKETLKLLTARGINFVFATGRHHVDVGQIRDNLEIKSYMITSNGARVHDLDGNLIFAHNLDRDIASDLFGVVNDNPDIITNVYRDDEWFMNRHRPEEMSFFKEAVFKYALYEPGLLEPEGVSKVFFTCDSHEQLLPLEQAINARWGDRVNVSFSTLTCLEVMAGGVSKGHALEAVAKKLGYSLKDCIAFGDGMNDAEMLSMAGKGCIMGSAHQRLKDLHPELEVIGTNADDAVPHYLRKLYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A58</accession>
    <name>Q32A58_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yiiD</name>
        <name evidence="2" type="ordered locus">SDY_3855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405288.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A58"/>
    <dbReference type="STRING" id="300267.SDY_3855"/>
    <dbReference type="EnsemblBacteria" id="ABB63797">
        <property type="protein sequence ID" value="ABB63797"/>
        <property type="gene ID" value="SDY_3855"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3855"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4555"/>
    <dbReference type="HOGENOM" id="CLU_063776_0_0_6"/>
    <dbReference type="OMA" id="SEKDGYD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008870">
        <property type="term" value="F:galactoside O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012660">
        <property type="entry name" value="YiiD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09500">
        <property type="entry name" value="YiiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02447">
        <property type="entry name" value="yiiD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="329" mass="37154" checksum="73D0D9537DF68076" modified="2005-12-06" version="1">MSQLPGLSWETRESIAMYHLRVPQTEEELERYYQFRWEMLRKPLHQPKGSERDAWDAMAHHQMVVDEQGNLVAVGRLYINTDNEASIRFMAVHPDVQDKGLGTLMAMTLESVARQEGVKRVTCSAREDAVEFFAKLGFVNQGEITTPTTTPIRHFLMIKPVATLDDILHRGDWCAQLQQAWYEHIPLSEKMGVRIQQYTGQKFITTMPETGNQNPHHTLFAGSLFSLATLTGWGLIWLMLRERHLGGTIILADAHIRYSKPISGKPHAVADLGALSGDLDRLARGRKARVQMQVEIFGDETPGAVFEGTYIVLPAKPFGPYEEGGNEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A64</accession>
    <name>Q32A64_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Formate dehydrogenase-O, major subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fdoG</name>
        <name evidence="14" type="ordered locus">SDY_3849</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378913.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405282.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_3849"/>
    <dbReference type="KEGG" id="sdy:SDY_3849"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4548"/>
    <dbReference type="HOGENOM" id="CLU_000422_1_2_6"/>
    <dbReference type="OMA" id="KWDGAKW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047111">
        <property type="term" value="F:formate dehydrogenase (cytochrome-c-553) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006443">
        <property type="entry name" value="Formate-DH-alph_fdnG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01553">
        <property type="entry name" value="formate-DH-alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0711">Selenium</keyword>
    <keyword evidence="8 14" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="14">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB63791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112549" checksum="155F0DD7B533060B" modified="2008-02-26" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A71</accession>
    <name>RHAR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional activator RhaR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-rhamnose operon transcriptional activator RhaR</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhaR</name>
        <name type="ordered locus">SDY_3840</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Activates expression of the rhaSR operon in response to L-rhamnose.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds DNA as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63784" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63784.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405275.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A71"/>
    <dbReference type="SMR" id="Q32A71"/>
    <dbReference type="STRING" id="300267.SDY_3840"/>
    <dbReference type="EnsemblBacteria" id="ABB63784">
        <property type="protein sequence ID" value="ABB63784"/>
        <property type="gene ID" value="SDY_3840"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3840"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4535"/>
    <dbReference type="HOGENOM" id="CLU_000445_88_5_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019299">
        <property type="term" value="P:rhamnose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01533">
        <property type="entry name" value="HTH_type_RhaR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023699">
        <property type="entry name" value="Tscrpt_act_RhaR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0684">Rhamnose metabolism</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000292775" description="HTH-type transcriptional activator RhaR">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="179"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with sigma-70" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="282" mass="32363" checksum="12930B0107774999" modified="2007-07-24" version="2">MVHQLKLLKDDFFASDQQAVAVADCYPQDVFAEHTHDFCELVIVWRGNGLHVLNDRPYRITRGDLFYIHADDKHSYASVNDLVLQNIIYCPERLKLNLDWQGAIPGFSVSAGQPHWRLGSMGMAQARQIIGQLEHESSQHVPFANEMAELLFGQLVMLLNRHRYTSDSLPPTSSETLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQWRHLNSQKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AG7</accession>
    <name>THIC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="1">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="1">HMP-P synthase</shortName>
            <shortName evidence="1">HMP-phosphate synthase</shortName>
            <shortName evidence="1">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiC</name>
        <name type="ordered locus">SDY_3732</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001276934.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405179.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AG7"/>
    <dbReference type="SMR" id="Q32AG7"/>
    <dbReference type="STRING" id="300267.SDY_3732"/>
    <dbReference type="EnsemblBacteria" id="ABB63688">
        <property type="protein sequence ID" value="ABB63688"/>
        <property type="gene ID" value="SDY_3732"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3732"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4424"/>
    <dbReference type="HOGENOM" id="CLU_013181_2_1_6"/>
    <dbReference type="OMA" id="TWELFRD"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025747">
        <property type="entry name" value="ThiC-associated_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13667">
        <property type="entry name" value="ThiC-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000242303" description="Phosphomethylpyrimidine synthase">
        <location>
            <begin position="1"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="353"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="394"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <sequence length="631" mass="70806" checksum="E61D30627B5BAF69" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AN0</accession>
    <name>Q32AN0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">malP</name>
        <name evidence="11" type="ordered locus">SDY_3659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000081869.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405116.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AN0"/>
    <dbReference type="STRING" id="300267.SDY_3659"/>
    <dbReference type="CAZy" id="GT35">
        <property type="family name" value="Glycosyltransferase Family 35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63625">
        <property type="protein sequence ID" value="ABB63625"/>
        <property type="gene ID" value="SDY_3659"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3659"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4341"/>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_6"/>
    <dbReference type="OMA" id="HCACSVA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="797" mass="90485" checksum="098D794B2D0782FB" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AV5</accession>
    <name>GLGC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="1">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgC</name>
        <name type="ordered locus">SDY_3576</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by fructose-1,6-bisphosphate (F16BP) and inhibited by AMP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000253975.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405041.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AV5"/>
    <dbReference type="SMR" id="Q32AV5"/>
    <dbReference type="STRING" id="300267.SDY_3576"/>
    <dbReference type="EnsemblBacteria" id="ABB63550">
        <property type="protein sequence ID" value="ABB63550"/>
        <property type="gene ID" value="SDY_3576"/>
    </dbReference>
    <dbReference type="GeneID" id="66672686"/>
    <dbReference type="KEGG" id="sdy:SDY_3576"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4247"/>
    <dbReference type="HOGENOM" id="CLU_029499_14_1_6"/>
    <dbReference type="OMA" id="QEWDVDE"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0321">Glycogen metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000261901" description="Glucose-1-phosphate adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="419"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="429"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <sequence length="431" mass="48698" checksum="3C0A4C4F5B13D9D3" modified="2005-12-06" version="1">MVSLEKNDHLMLARQLPLKSVALILAGGRGTRLKDLTNKRAKPAVHFGGKFRIIDFALSNCINSGIRRMGVITQYQSHTLVQHIQRGWSFFNEEMNEFVDLLPAQQRMKGENWYRGTADAVTQNLDIIRRYKAEYVVILAGDHIYKQDYSRMLIDHVEKGARCTVACMPVPIEEASAFGVMAVDENDKIIEFVEKPANPPSMPNDPSKSLASMGIYVFDADYLYELLEEDDRDENSSHDFGKDLIPKITEAGLAYAHPFPLSCVQSDPDAEPYWRDVGTLEAYWKANLDLASVVPELDMYDRNWPIRTYNESLPPAKFVQDRSGSHGMTLNSLVSGGCVISGSVVVQSVLFSRVRVNSFCNIDSAVLLPEVWVGRSCRLRRCVIDRACVIPEGMVIGENAEEDARRFYRSEEGIVLVTREMLRKLGHKQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AZ3</accession>
    <name>Q32AZ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AZ3"/>
    <dbReference type="EnsemblBacteria" id="ABB63512">
        <property type="protein sequence ID" value="ABB63512"/>
        <property type="gene ID" value="SDY_3536"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3536"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8253" checksum="9AAE3426CC0A8459" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITQTILRFVHRIRDDWISMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B09</accession>
    <name>Q32B09_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-activated global transcriptional regulator CRP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Catabolite activator protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Catabolite gene activator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">cAMP receptor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">cAMP regulatory protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">crp</name>
        <name evidence="10" type="ordered locus">SDY_3519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000242755.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404987.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B09"/>
    <dbReference type="SMR" id="Q32B09"/>
    <dbReference type="STRING" id="300267.SDY_3519"/>
    <dbReference type="EnsemblBacteria" id="ABB63496">
        <property type="protein sequence ID" value="ABB63496"/>
        <property type="gene ID" value="SDY_3519"/>
    </dbReference>
    <dbReference type="GeneID" id="67450219"/>
    <dbReference type="KEGG" id="sdy:SDY_3519"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4174"/>
    <dbReference type="HOGENOM" id="CLU_075053_3_5_6"/>
    <dbReference type="OMA" id="VLCRDFG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018335">
        <property type="entry name" value="Tscrpt_reg_HTH_Crp-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00042">
        <property type="entry name" value="HTH_CRP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="8">
        <location>
            <begin position="24"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="9">
        <location>
            <begin position="138"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="210" mass="23640" checksum="DCBC24FA46C61B3D" modified="2005-12-06" version="1">MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B50</accession>
    <name>RL15_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplO</name>
        <name type="ordered locus">SDY_3477</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001238917.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404946.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B50"/>
    <dbReference type="SMR" id="Q32B50"/>
    <dbReference type="STRING" id="300267.SDY_3477"/>
    <dbReference type="EnsemblBacteria" id="ABB63455">
        <property type="protein sequence ID" value="ABB63455"/>
        <property type="gene ID" value="SDY_3477"/>
    </dbReference>
    <dbReference type="GeneID" id="67415342"/>
    <dbReference type="KEGG" id="sdy:SDY_3477"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4130"/>
    <dbReference type="HOGENOM" id="CLU_055188_4_2_6"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000251561" description="50S ribosomal protein L15">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="144" mass="14966" checksum="90D14CCBCA114D5B" modified="2005-12-06" version="1">MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEVRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B51</accession>
    <name>Q32B51_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">prlA</name>
        <name evidence="9" type="synonym">secY</name>
        <name evidence="13" type="ordered locus">SDY_3476</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001118855.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404945.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B51"/>
    <dbReference type="STRING" id="300267.SDY_3476"/>
    <dbReference type="EnsemblBacteria" id="ABB63454">
        <property type="protein sequence ID" value="ABB63454"/>
        <property type="gene ID" value="SDY_3476"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3476"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4129"/>
    <dbReference type="HOGENOM" id="CLU_030313_0_2_6"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="443" mass="48528" checksum="6800A6358247FAD3" modified="2005-12-06" version="1">MAKQPGLDFQSAKGGLGELKRRLLFVIGALIVFRIGSFIPIPGIDAAVLAKLLEQQRGTIIEMFNMFSGGALSRASIFALGIMPYISASIIIQLLTVVHPTLAEIKKEGESGRRKISQYTRYGTLVLAIFQSIGIATGLPNMLGMQGLVINPGFAFYFTAVVSLVTGTMFLMWLGEQITERGIGNGISIIIFAGIVAGLPPAIAHTIEQARQGDLHFLVLLLVAVLVFAVTFFVVFVERGQRRIVVNYAKRQQGRRVYAAQSTHLPLKVNMAGVIPAIFASSIILFPATIASWFGGGTGWNWLTTISLYLQPGQPLYVLLYASAIIFFCFFYTALVFNPRETADNLKKSGAFVPGIRPGEQTAKYIDKVMTRLTLVGALYITFICLIPEFMRDAMKVPFYFGGTSLLIVVVVIMDFMAQVQTLMMSSQYESALKKANLKGYGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B63</accession>
    <name>DEF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide deformylase</fullName>
            <shortName evidence="1">PDF</shortName>
            <ecNumber evidence="1">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">def</name>
        <name type="ordered locus">SDY_3463</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000114984.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404933.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B63"/>
    <dbReference type="SMR" id="Q32B63"/>
    <dbReference type="STRING" id="300267.SDY_3463"/>
    <dbReference type="EnsemblBacteria" id="ABB63442">
        <property type="protein sequence ID" value="ABB63442"/>
        <property type="gene ID" value="SDY_3463"/>
    </dbReference>
    <dbReference type="GeneID" id="67415327"/>
    <dbReference type="KEGG" id="sdy:SDY_3463"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4116"/>
    <dbReference type="HOGENOM" id="CLU_061901_2_1_6"/>
    <dbReference type="OMA" id="VCIQHEI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000301097" description="Peptide deformylase">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <sequence length="169" mass="19328" checksum="C485EB6C1D2D91B8" modified="2005-12-06" version="1">MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELEADGLLAICIQHEMDHLVGKLFMDYLSPLKQQRIRQKVEKLDRLKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B82</accession>
    <name>Q32B82_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Biotin carboxylase</fullName>
            <ecNumber evidence="5 13">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">accC</name>
        <name evidence="16" type="ordered locus">SDY_3433</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5 13"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000884639.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404914.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B82"/>
    <dbReference type="SMR" id="Q32B82"/>
    <dbReference type="STRING" id="300267.SDY_3433"/>
    <dbReference type="EnsemblBacteria" id="ABB63423">
        <property type="protein sequence ID" value="ABB63423"/>
        <property type="gene ID" value="SDY_3433"/>
    </dbReference>
    <dbReference type="GeneID" id="58460262"/>
    <dbReference type="KEGG" id="sdy:SDY_3433"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4089"/>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_6"/>
    <dbReference type="OMA" id="FVEICSH"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0092">Biotin</keyword>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="15">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB63423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="449" mass="49321" checksum="68C55F10ACB4F170" modified="2005-12-06" version="1">MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKLGLQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B89</accession>
    <name>Q32B89_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mreB</name>
        <name evidence="3" type="ordered locus">SDY_3426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B89"/>
    <dbReference type="STRING" id="300267.SDY_3426"/>
    <dbReference type="EnsemblBacteria" id="ABB63416">
        <property type="protein sequence ID" value="ABB63416"/>
        <property type="gene ID" value="SDY_3426"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3426"/>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_6"/>
    <dbReference type="OMA" id="MVICIPS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="316"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="367" mass="38973" checksum="6B046D7FB2041762" modified="2005-12-06" version="1">MVGKVSGFSFPPQLSGLSLSMLKKFRGMFSNDLSIDLGTANTLIYVKGQGIVLNEPSVVAIRQDRAGSPKSVAAVGHDAKQMLGRTPGNIAAIRPMKDGVIADFFVTEKMLQHFIKQVHSNSFMRPSPRVLVCVPVGATQVERRAIRESAQGAGAREVFLIEEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAVISLNGVVYSSSVRIGGDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGDEVREIEVRGRNLAEGVPRGFTLNSNEILEALQEPLTGIVSAVMVALEQCPPELASDISERGMVLTGGGALLRNLDRLLMEETGIPVVVAEDPLTCVARGGGKALEMIDMHGGDLFSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B93</accession>
    <name>Q32B93_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonuclease G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cafA</name>
        <name evidence="9" type="ordered locus">SDY_3422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase E/G family. RNase G subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B93"/>
    <dbReference type="STRING" id="300267.SDY_3422"/>
    <dbReference type="EnsemblBacteria" id="ABB63412">
        <property type="protein sequence ID" value="ABB63412"/>
        <property type="gene ID" value="SDY_3422"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3422"/>
    <dbReference type="HOGENOM" id="CLU_003468_5_3_6"/>
    <dbReference type="OMA" id="TKGPRIS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="495" mass="56064" checksum="450D76FF57D497B3" modified="2005-12-06" version="1">MRKGINMTAELLVNVTPSETRVAYIDGGILQEIHIEREARRGIVGNIYKGRVSRVLPGMQAAFVDIGLDKAAFLHASDIMPHTECVAGEEQKQFTVRDISELVRQGQDLMVQVVKDPLGTKGARLTTDITLPSRYLVFMPGASHVGVSQRIESESERERLKKVVAEYCDEQGGFIIRTAAEGVGEAELASDAAYLKRVWTKVMERKKRPQTRYQLYGELALAQRVLRDFADAELDRIRVDSRLTYEALLEFTSEYIPEMTSKLEHYTGRQPIFDLFDVENEIQRALERKVELKSGGYLIIDQTEAMTTVDINTGAFVGHRNLDDTIFNTNIEATQAIARQLRLRNLGGIIIIDFIDMNNEDHRRRVLHSLEQALSKDRVKTSVNGFSALGLVEMTRKRTRESIEHVLCNECPTCHGRGTVKTVETVCYEIMREIVRVHHAYDSDRFLVYASPAVAEALKGEESHSLAEVEIFVGKQVKVQIEPLYNQEQFDVVMM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BA8</accession>
    <name>RL13_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplM</name>
        <name type="ordered locus">SDY_3407</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018883.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404888.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BA8"/>
    <dbReference type="SMR" id="Q32BA8"/>
    <dbReference type="STRING" id="300267.SDY_3407"/>
    <dbReference type="EnsemblBacteria" id="ABB63397">
        <property type="protein sequence ID" value="ABB63397"/>
        <property type="gene ID" value="SDY_3407"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3407"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4065"/>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_6"/>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000261799" description="50S ribosomal protein L13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <sequence length="142" mass="15958" checksum="59F15EF9EB75FDD6" modified="2005-12-06" version="1">MKTFTAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNADKVAVTGNKRTDKVYYHHTGHIGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMSRKLKVYAGNEHNHAAQQPQVLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BC7</accession>
    <name>Q32BC7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphocarrier protein HPr-like NPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptsO</name>
        <name evidence="5" type="ordered locus">SDY_3387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000216791.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404869.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BC7"/>
    <dbReference type="SMR" id="Q32BC7"/>
    <dbReference type="STRING" id="300267.SDY_3387"/>
    <dbReference type="EnsemblBacteria" id="ABB63378">
        <property type="protein sequence ID" value="ABB63378"/>
        <property type="gene ID" value="SDY_3387"/>
    </dbReference>
    <dbReference type="GeneID" id="66672892"/>
    <dbReference type="KEGG" id="sdy:SDY_3387"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4041"/>
    <dbReference type="HOGENOM" id="CLU_136230_1_3_6"/>
    <dbReference type="OMA" id="HARPAMM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="4">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="9810" checksum="12A8EFEB514F6015" modified="2005-12-06" version="1">MTVKQTVEITNKLGMHARPAMKLFELMQGFDAEVLLRNDEGTEAEANSVIALLMLDSAKGRQIEVEATGPQEEEALAAVIALFNSGFDED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BH9</accession>
    <name>YHBP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0306 protein YhbP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yhbP</name>
        <name type="ordered locus">SDY_3333</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0306 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000449041.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404817.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BH9"/>
    <dbReference type="SMR" id="Q32BH9"/>
    <dbReference type="STRING" id="300267.SDY_3333"/>
    <dbReference type="EnsemblBacteria" id="ABB63326">
        <property type="protein sequence ID" value="ABB63326"/>
        <property type="gene ID" value="SDY_3333"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3333"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3987"/>
    <dbReference type="HOGENOM" id="CLU_105087_3_0_6"/>
    <dbReference type="OMA" id="DLWCANC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00764">
        <property type="entry name" value="UPF0306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011194">
        <property type="entry name" value="UPF0306"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009554">
        <property type="entry name" value="UCP009554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000046783" description="UPF0306 protein YhbP">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00764"/>
        </source>
    </evidence>
    <sequence length="147" mass="16748" checksum="39A2EC7753EC91D3" modified="2005-12-06" version="1">METLITISRWLAKQHVVTWCVQQEGELWCANAFYLFDAQKVAFYILTEEKTRHAQMSGPQAAVAGTVNGQPKTVALIRGVQFKGEIRRLEGEESDLARKAYNRRFPVARMLSAPVWEIRLDEIKFTDNTLGFGKKMIWLRGSGTEQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BU5</accession>
    <name>ZUPT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc transporter ZupT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">zupT</name>
        <name type="ordered locus">SDY_3200</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates zinc uptake. May also transport other divalent cations.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018485.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404701.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BU5"/>
    <dbReference type="SMR" id="Q32BU5"/>
    <dbReference type="STRING" id="300267.SDY_3200"/>
    <dbReference type="EnsemblBacteria" id="ABB63210">
        <property type="protein sequence ID" value="ABB63210"/>
        <property type="gene ID" value="SDY_3200"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3200"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3824"/>
    <dbReference type="HOGENOM" id="CLU_015114_1_3_6"/>
    <dbReference type="OMA" id="MIFVVIE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00548">
        <property type="entry name" value="ZupT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023498">
        <property type="entry name" value="Zn_transptr_ZupT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0864">Zinc transport</keyword>
    <feature type="chain" id="PRO_1000017778" description="Zinc transporter ZupT">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00548"/>
        </source>
    </evidence>
    <sequence length="257" mass="26483" checksum="DC883ECD3F440877" modified="2005-12-06" version="1">MSVPLILTILAGAATFIGAFLGVLGQKTSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSPVLGYGMFIFGLLGYLGLDRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVVGPVYAATGSKRTAILWAGISGLAEILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCGMSVMGFSLVLLQTAGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BV6</accession>
    <name>Q32BV6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiol:disulfide interchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dsbC</name>
        <name evidence="9" type="ordered locus">SDY_3189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thioredoxin family. DsbC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000715209.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404690.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BV6"/>
    <dbReference type="STRING" id="300267.SDY_3189"/>
    <dbReference type="EnsemblBacteria" id="ABB63199">
        <property type="protein sequence ID" value="ABB63199"/>
        <property type="gene ID" value="SDY_3189"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3189"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3811"/>
    <dbReference type="HOGENOM" id="CLU_083593_0_0_6"/>
    <dbReference type="OMA" id="QMIVYKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03020">
        <property type="entry name" value="DsbA_DsbC_DsbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033954">
        <property type="entry name" value="DiS-bond_Isoase_DsbC/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018950">
        <property type="entry name" value="DiS-bond_isomerase_DsbC/G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009094">
        <property type="entry name" value="DiS-bond_isomerase_DsbC/G_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10411">
        <property type="entry name" value="DsbC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54423">
        <property type="entry name" value="SSF54423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010009439" description="Thiol:disulfide interchange protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="236" mass="25635" checksum="A2C529A666BAB251" modified="2005-12-06" version="1">MKKGFMLFTLLAAFSGFAQADDAAIQQTLAKMGIKSSDIQPAPVAGMKTVLTNSGVLYITDDGKHIIQGPMYDVSGTAPVNVTNKMLLKQLNALEKEMIVYKAPQEKHVITVFTDITCGYCHKLHEQMADYNALGITVRYLAFPRQGLDSDAEKEMKAIWCAKDKNKAFDDVMAGKSVAPANCDVDIADHYALGVQLGVSGTPAVVLSNGTLVPGYQPPKDMKEFLDEHQKMTSGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BW1</accession>
    <name>YGFZ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-modifying protein YgfZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygfZ</name>
        <name type="ordered locus">SDY_3184</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA-modifying YgfZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000886092.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404685.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BW1"/>
    <dbReference type="SMR" id="Q32BW1"/>
    <dbReference type="STRING" id="300267.SDY_3184"/>
    <dbReference type="EnsemblBacteria" id="ABB63194">
        <property type="protein sequence ID" value="ABB63194"/>
        <property type="gene ID" value="SDY_3184"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3184"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3805"/>
    <dbReference type="HOGENOM" id="CLU_007884_6_1_6"/>
    <dbReference type="OMA" id="VNFKKGC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01175">
        <property type="entry name" value="tRNA_modifying_YgfZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023758">
        <property type="entry name" value="tRNA-modifying_YgfZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0290">Folate-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000262900" description="tRNA-modifying protein YgfZ">
        <location>
            <begin position="2"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>folate</name>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>folate</name>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01175"/>
        </source>
    </evidence>
    <sequence length="326" mass="36195" checksum="F425D7BAB764BF31" modified="2007-01-23" version="3">MAFTPFPPRQPTASARLPLTLMTLDDWALATITGADSEKYMQGQVTADVSQMTEDQHLQAAHCDAKGKMWSNLRLFRDGDGFAWIERRSVREPQLTELKKYAVFSKVTIAPDDERVLLGVAGFQARAALANLFSELPSKEKQVVREGATTLLWFEHPAERFLIVTDEATANMLTDKLRGEAELNNSQQWLALNIEAGFPVIDAANSGQFIPQATNLQALGGISFKKGCYTGQEMVARAKFRGANKRALWLLAGSASRLPEAGEDLELRMGENWRRTGTVLAAVKLEDGQVVVQVVMNNDMEPDSIFRVRDDANTLHIEPLPYSLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BW2</accession>
    <name>Q32BW2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_3183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404684.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BW2"/>
    <dbReference type="STRING" id="300267.SDY_3183"/>
    <dbReference type="EnsemblBacteria" id="ABB63193">
        <property type="protein sequence ID" value="ABB63193"/>
        <property type="gene ID" value="SDY_3183"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3183"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3804"/>
    <dbReference type="HOGENOM" id="CLU_051078_1_0_6"/>
    <dbReference type="OMA" id="HEVFHSL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="224" mass="24498" checksum="10F6B9D6D1BB6AD7" modified="2005-12-06" version="1">MNVNAGHERTSKARIIHQIQLIRGITSHGIGLVFGIVGLVLLLVQAVDLNASATAITSYSLYGGSMILLFLASTLYHAIPHQRAKMWLKKFDHCAIYLLIAGTYTPFLLVGLDSPLARGLMIVIWSLALLGILFKLTIAHRFKILSLVIYLAMGWLSLVVIYEMAVKLAAGSVTLLAVGGVVYSLGVIFYVCKRIPYNHAIWHGFVLGGSVCHFLAIYLYIGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C27</accession>
    <name>Q32C27_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yggN</name>
        <name evidence="2" type="ordered locus">SDY_3114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000984796.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404619.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C27"/>
    <dbReference type="SMR" id="Q32C27"/>
    <dbReference type="STRING" id="300267.SDY_3114"/>
    <dbReference type="EnsemblBacteria" id="ABB63128">
        <property type="protein sequence ID" value="ABB63128"/>
        <property type="gene ID" value="SDY_3114"/>
    </dbReference>
    <dbReference type="GeneID" id="67415150"/>
    <dbReference type="KEGG" id="sdy:SDY_3114"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3724"/>
    <dbReference type="HOGENOM" id="CLU_1159649_0_0_6"/>
    <dbReference type="OMA" id="NPLQAMM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021307">
        <property type="entry name" value="DUF2884"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11101">
        <property type="entry name" value="DUF2884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220638" evidence="1">
        <location>
            <begin position="21"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="239" mass="26429" checksum="0D0B47E72674705F" modified="2005-12-06" version="1">MMRKMLLAAALSVTAMTAHADYQCSVTPRDDVIVSPQTVQVKGENGNLVITPDGNVMYNGKQYSLNAAQREQAKDYQAELRSTLPWIDEGAKSRVEKARIALDKIIVQEMGESSKMRSRLTKLDAQLKEQMNRIIETRSDGLTFHYKAIDQVRAEGQQLVNQAMGGILQDSINEMGAKAVLKSGGNPLQNVLGSLGGLQSSIQTEWKKQEKDFQQFGKDVCSRVVTLEDSRKALVGNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C85</accession>
    <name>Q32C85_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-acyl-glycerophospho-ethanolamine acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aas</name>
        <name evidence="4" type="ordered locus">SDY_3053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000899075.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404561.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C85"/>
    <dbReference type="STRING" id="300267.SDY_3053"/>
    <dbReference type="EnsemblBacteria" id="ABB63070">
        <property type="protein sequence ID" value="ABB63070"/>
        <property type="gene ID" value="SDY_3053"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3053"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3658"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_8_6"/>
    <dbReference type="OMA" id="ANWVYLE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="3">
        <location>
            <begin position="30"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="719" mass="80889" checksum="9CFD000A25FE1D4F" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CG8</accession>
    <name>Q32CG8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404478.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CG8"/>
    <dbReference type="EnsemblBacteria" id="ABB62987">
        <property type="protein sequence ID" value="ABB62987"/>
        <property type="gene ID" value="SDY_2961"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2961"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3553"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="TSHEHTE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="270" mass="31157" checksum="0CEA1322A0931E29" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQSGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSECCSQNKNAPIISDRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CN3</accession>
    <name>Q32CN3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yqaB</name>
        <name evidence="2" type="ordered locus">SDY_2887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000273317.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404413.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CN3"/>
    <dbReference type="STRING" id="300267.SDY_2887"/>
    <dbReference type="EnsemblBacteria" id="ABB62922">
        <property type="protein sequence ID" value="ABB62922"/>
        <property type="gene ID" value="SDY_2887"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2887"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3471"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_6"/>
    <dbReference type="OMA" id="YHGRRPM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="188" mass="20827" checksum="6661631E7544BDBE" modified="2005-12-06" version="1">MYERYAGLIFDMDGTILDTEPTHRKAWREVLGHYGLQYDVQAMIALNGSPTWRIAQAIIELNQADLDPHALAREKTEAVRSMLLDSVEPLPLVEVVKSWHGRRPMVVGTGSESAIAEALLAHLGLRRYFDAVVAADHVKHHKPAPDTFLLCAQRMGVQPTQCVVFEDADFGIQAARAAGMDAVDVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CW1</accession>
    <name>Q32CW1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yfhL</name>
        <name evidence="5" type="ordered locus">SDY_2801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000054753.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404335.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CW1"/>
    <dbReference type="STRING" id="300267.SDY_2801"/>
    <dbReference type="EnsemblBacteria" id="ABB62844">
        <property type="protein sequence ID" value="ABB62844"/>
        <property type="gene ID" value="SDY_2801"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2801"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3376"/>
    <dbReference type="HOGENOM" id="CLU_139698_11_0_6"/>
    <dbReference type="OMA" id="DCCVPDD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9892" checksum="15DD68E4B1E85C01" modified="2005-12-06" version="1">MSLLITKRCINCDMCEPECPNEAISMGDHIYEINSDKCTECVGHYETPTCQKVCPIPNTIVKDPQHVETEEQLWDKFVLMHHADKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CW4</accession>
    <name>Q32CW4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404332.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CW4"/>
    <dbReference type="STRING" id="300267.SDY_2798"/>
    <dbReference type="EnsemblBacteria" id="ABB62841">
        <property type="protein sequence ID" value="ABB62841"/>
        <property type="gene ID" value="SDY_2798"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2798"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3372"/>
    <dbReference type="HOGENOM" id="CLU_029251_0_0_6"/>
    <dbReference type="OMA" id="WFNSIQF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="311" mass="35318" checksum="CD78FD472B7766BB" modified="2005-12-06" version="1">MAHKYVRRWINLTGTPAPNGLVDLWGQAWFVDQGQRLGRTYGAFTSRWFNSIQFPGQSWTKLEPFAHSQAEIQRALADVTLSLDTADWFDIKAPIHNVIRVDMPPKAHQQYREMEKEMFLELNGEGIEAPNAAAKTLKCLQIASGAVYTDDAGSWSELHDTKLQALDSILTEAAGAPVLVAYHWKHDLERLLKAFPRGRHLDQDPQTLRDWNSGKIPVLFAHPASAGHGLNMQDGGNILVFFSHWWDLEQYQQIIERIGPTRQIQAGHNRPVFIHHIIAADTMDEMVMEQRNSKRTVQDILLDAMKKRGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CX6</accession>
    <name>Q32CX6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">yfjD</name>
        <name evidence="12" type="ordered locus">SDY_2786</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CX6"/>
    <dbReference type="STRING" id="300267.SDY_2786"/>
    <dbReference type="EnsemblBacteria" id="ABB62829">
        <property type="protein sequence ID" value="ABB62829"/>
        <property type="gene ID" value="SDY_2786"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2786"/>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_6"/>
    <dbReference type="OMA" id="TIGRQHP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="264"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="420" mass="47149" checksum="E75F37E6D8FC0E96" modified="2005-12-06" version="1">MIIILIIMVVISAYFSGSETGMMTLNRYRLRHMAKQGNRSAKRVEKLLRKPDRLISLVLIGNNLVNILASALGTIVGMRLYGDAGVAIATGVLTFVVLVFAEVLPKTIAALYPEKVAYPSSFLLAPLQILMMPLVWLLNAITRMLMRMMGIKTDIVVSGSLSKEELRTIVHESRSQISRRNQDMLLSVLDLEKMTVDDIMVPRSEIIGIDINDDWKSILRQLSHSPHGRIVLYRDSLDDAISMLRVREAWRLMSEKKEFTKETMLRAADESYFVPEGTPLSTQLVKFQRNKKKVGLVVNEYGDIQGLVTVEDILEEIVGDFTTSMSPTLAEEVTPQNDGSVIIDGTANVREINKAFNWHLPEDDARTVNGVILEALEEIPVAGTRVRIGEYDIDILDVQDNMIKQVKIFPVKPLRESVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CZ7</accession>
    <name>Q32CZ7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroF</name>
        <name evidence="7" type="ordered locus">SDY_2765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001168045.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404299.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CZ7"/>
    <dbReference type="SMR" id="Q32CZ7"/>
    <dbReference type="STRING" id="300267.SDY_2765"/>
    <dbReference type="EnsemblBacteria" id="ABB62808">
        <property type="protein sequence ID" value="ABB62808"/>
        <property type="gene ID" value="SDY_2765"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2765"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3332"/>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_6"/>
    <dbReference type="OMA" id="VMENVAN"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="39"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="356" mass="38818" checksum="A4BD42AE30220B6D" modified="2005-12-06" version="1">MQKDALNNVHITDEQVLMTPEQLKAAFPLSLQQEAQIADSRKTISDIIAGRDPRLLVVCGPCSIHDPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEAGLQIARKLLLELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAQPHRFVGINQAGQVALLQTQGNPDGHVILRGGKAPNYSPADVAQCEKEMEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGNQSSEQPRSEMKYGVSVTDACISWEMTDALLREIHQDLNGQLTARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D00</accession>
    <name>Q32D00_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfiL</name>
        <name evidence="2" type="ordered locus">SDY_2762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005017277.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404296.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D00"/>
    <dbReference type="STRING" id="300267.SDY_2762"/>
    <dbReference type="EnsemblBacteria" id="ABB62805">
        <property type="protein sequence ID" value="ABB62805"/>
        <property type="gene ID" value="SDY_2762"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2762"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3329"/>
    <dbReference type="HOGENOM" id="CLU_128661_0_0_6"/>
    <dbReference type="OMA" id="DWYQIGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021242">
        <property type="entry name" value="DUF2799"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10973">
        <property type="entry name" value="DUF2799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221024" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="122" mass="13394" checksum="2BABC338500FF255" modified="2005-12-06" version="1">MMKKFIAPLLALLVSGCQIDPYTHAPTLTSTDWYDVGMEDAISGSAIKDDDAFSDSQADRGLYLKGYAEGQKKTCQTDFTYARGLSGKSFPASCNNVENASQLHEVWQKGVMLPISRTCVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D49</accession>
    <name>Q32D49_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ancillary SecYEG translocon subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_2709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the YfgM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000409205.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404247.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D49"/>
    <dbReference type="SMR" id="Q32D49"/>
    <dbReference type="STRING" id="300267.SDY_2709"/>
    <dbReference type="EnsemblBacteria" id="ABB62756">
        <property type="protein sequence ID" value="ABB62756"/>
        <property type="gene ID" value="SDY_2709"/>
    </dbReference>
    <dbReference type="GeneID" id="66673599"/>
    <dbReference type="KEGG" id="sdy:SDY_2709"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3267"/>
    <dbReference type="HOGENOM" id="CLU_084785_0_0_6"/>
    <dbReference type="OMA" id="RFFANNG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018704">
        <property type="entry name" value="TPR_21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026039">
        <property type="entry name" value="YfgM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38035">
        <property type="entry name" value="PTHR38035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09976">
        <property type="entry name" value="TPR_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006170">
        <property type="entry name" value="YfgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_21" evidence="5">
        <location>
            <begin position="15"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="206" mass="22176" checksum="2DAFC595EBDC5EEB" modified="2005-12-06" version="1">MEIYENENDQVEAVKRFFAENGKALAVGVILGVGALIGWRYWNSHQVDSARSASLAYQNAVTAVSEGKPDSIPAAEKFAAENKNTYGALASLELAQQFVDKNELEKAAAQLQQGLADTSDENLKAVINLRLARVQVQLKQADAALKTLDTIKGEGWAAIVADLRGEALLSKGDKQGARSAWEAGVKSDVTPALSEMMQMKINNLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DA7</accession>
    <name>Q32DA7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative multimodular enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">SDY_2645</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000342643.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404189.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DA7"/>
    <dbReference type="STRING" id="300267.SDY_2645"/>
    <dbReference type="EnsemblBacteria" id="ABB62698">
        <property type="protein sequence ID" value="ABB62698"/>
        <property type="gene ID" value="SDY_2645"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2645"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3184"/>
    <dbReference type="HOGENOM" id="CLU_012366_0_0_6"/>
    <dbReference type="OMA" id="NIWVTDL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012188">
        <property type="entry name" value="ME_PTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036684">
        <property type="entry name" value="ME_PTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="12">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="11">
        <location>
            <begin position="163"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="76"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB62698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="759" mass="82427" checksum="9947A8DAAF9125BA" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DC6</accession>
    <name>MURQ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="1">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="1">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murQ</name>
        <name type="ordered locus">SDY_2624</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">Induced by MurNAc 6-phosphate that releases the repressor MurR from the DNA. Repressed by MurR in the absence of MurNAc 6-phosphate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001175604.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404170.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DC6"/>
    <dbReference type="SMR" id="Q32DC6"/>
    <dbReference type="STRING" id="300267.SDY_2624"/>
    <dbReference type="EnsemblBacteria" id="ABB62679">
        <property type="protein sequence ID" value="ABB62679"/>
        <property type="gene ID" value="SDY_2624"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2624"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3161"/>
    <dbReference type="HOGENOM" id="CLU_049049_1_1_6"/>
    <dbReference type="OMA" id="CPPTFCT"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="UniPathway" id="UPA00343"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097175">
        <property type="term" value="P:1,6-anhydro-N-acetyl-beta-muramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000249651" description="N-acetylmuramic acid 6-phosphate etherase">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="55"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <sequence length="298" mass="31126" checksum="2C1338C13ADCBF46" modified="2005-12-06" version="1">MQLEKMITEGSNAASAEIDRVSTLEMCRIINDEDKTVPLAVERVLPDIAAAIDVIHAQVSGGGRLIYLGAGTSGRLGILDASECPPTYGVKPGLVVGLIAGGEYAIQHAVEGAEDSREGGINDLKNIGLTAQDVVVGIAASGRTPYVIAGLEYARQLGCRTVGISCNPGSAVSTTAEFAITPVVGAEVVTGSSRMKAGTAQKLVLNMLSTGLMIKSGKVFGNLMVDVVATNEKLHVRQVNIVKNATGCNAEQAEAALIACERNCKTAIVMVLKNLDAAEAKKRLDQHGGFIRQVLDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DD1</accession>
    <name>Q32DD1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC-type sulfate transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysW</name>
        <name evidence="13" type="ordered locus">SDY_2619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000852687.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404165.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DD1"/>
    <dbReference type="STRING" id="300267.SDY_2619"/>
    <dbReference type="EnsemblBacteria" id="ABB62674">
        <property type="protein sequence ID" value="ABB62674"/>
        <property type="gene ID" value="SDY_2619"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2619"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3156"/>
    <dbReference type="HOGENOM" id="CLU_016047_14_0_6"/>
    <dbReference type="OMA" id="NEYNFVA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011866">
        <property type="entry name" value="CysW_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF9">
        <property type="entry name" value="PTHR30406:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02140">
        <property type="entry name" value="permease_CysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="66"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB62674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="291" mass="32564" checksum="02C8BEA4EB3F6E67" modified="2005-12-06" version="1">MAEVTQLKRYDARPINWGKWFLIGIGMLVSAFILLVPMIYIFVQAFSKGLMPVLQNLADPDMLHAIWLTVMIALIAVPVNLVFGILLAWLVTRFNFPGRQLLLTLLDIPFAVSPVVAGLVYLLFYGSNGPLGGWLDEHNLQIMFSWPGMVLVTIFVTCPFVVRELVPVMLSQGSQEDEAAILLGASGWQMFRRVTLPNIRWALLYGVVLTNARAIGEFGAVSVVSGSIRGETLSLPLQIELLEQDYNTVGSFTAAALLTLMAIITLFLKSMLQWRLENQEKRAQQEEHHEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DH8</accession>
    <name>SDHD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-serine dehydratase</fullName>
            <ecNumber evidence="1">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-serine deaminase</fullName>
            <shortName evidence="1">DSD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dsdA</name>
        <name type="ordered locus">SDY_2561</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine/threonine dehydratase family. DsdA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000427356.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404118.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DH8"/>
    <dbReference type="SMR" id="Q32DH8"/>
    <dbReference type="STRING" id="300267.SDY_2561"/>
    <dbReference type="EnsemblBacteria" id="ABB62627">
        <property type="protein sequence ID" value="ABB62627"/>
        <property type="gene ID" value="SDY_2561"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2561"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3085"/>
    <dbReference type="HOGENOM" id="CLU_035707_0_0_6"/>
    <dbReference type="OMA" id="ESDPNCF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046416">
        <property type="term" value="P:D-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01030">
        <property type="entry name" value="D_Ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011780">
        <property type="entry name" value="D_Ser_am_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF9">
        <property type="entry name" value="PTHR48078:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02035">
        <property type="entry name" value="D_Ser_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000291742" description="D-serine dehydratase">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01030"/>
        </source>
    </evidence>
    <sequence length="442" mass="47820" checksum="0D0F1C7143EFDF88" modified="2005-12-06" version="1">MENGKMNSLIAQYPLVKDLVALKETTWFNPGTTSLAEGLPYVGLTEQDVQDAHARLSRFAPYLAKAFPETAATGGIIESELVAIPAMQKRLEKEYQQPISGQLLLKKDSHLPISGSIKARGGIYEVLAHAEKLALEAGLLTLDADYSKLLSPEFKQFFSQYSIAVGSTGNLGLSIGIMSARIGFKVTVHMSADARAWKKAKLRSHGVTVVEYEQDYGVAVEEGRKAAQSDPNCFFIDDENSRTLFLGYSVAGQRLKAQFAQQGRIVDADNPLFVYLPCGVGGGPGGVAFGLKLAFGDHVHCFFAEPTHSPCMLLGVHTGLHDQISVQDIGIDNLTAADGLAVGRASGFVGRAMERLLDGFYTLSDQTMYDMLGWLAQEEGIRLEPSALAGMAGPQRVCASVSYQQMHGFNAEQLHNATHLVWATGGGMVPEEEMNQYLAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DU7</accession>
    <name>Q32DU7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">sn-glycerol-3-phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glpT</name>
        <name evidence="9" type="ordered locus">SDY_2435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000948705.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403999.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DU7"/>
    <dbReference type="STRING" id="300267.SDY_2435"/>
    <dbReference type="EnsemblBacteria" id="ABB62508">
        <property type="protein sequence ID" value="ABB62508"/>
        <property type="gene ID" value="SDY_2435"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2435"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2934"/>
    <dbReference type="HOGENOM" id="CLU_001265_31_0_6"/>
    <dbReference type="OMA" id="AMPYLID"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015169">
        <property type="term" value="F:glycerol-3-phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005267">
        <property type="entry name" value="G3P_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021159">
        <property type="entry name" value="Sugar-P_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00712">
        <property type="entry name" value="glpT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00942">
        <property type="entry name" value="GLPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="26"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="452" mass="50374" checksum="E195459B94F4E55B" modified="2005-12-06" version="1">MLSIFKPAPHKARLLAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFCAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKAEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIATIIYWMNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKRRHQELLQKRNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DY0</accession>
    <name>Q32DY0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Z1097 gene product</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403966.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DY0"/>
    <dbReference type="EnsemblBacteria" id="ABB62475">
        <property type="protein sequence ID" value="ABB62475"/>
        <property type="gene ID" value="SDY_2401"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2401"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2896"/>
    <dbReference type="HOGENOM" id="CLU_1073236_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="259" mass="29869" checksum="8FAFFD9AB2BFA229" modified="2005-12-06" version="1">MINNISDQASSFLGTQLNQSDNFLDSLREFFAILNSSRKDELSTWDTIYLHLILAINADSDLIKNDVLLAENIPTADYQFNTFFSNAFETDVKKYLGKSEDNEVEIKTGNERISIGIRNISNGKLERQKFLFPLDYENKLQHQLDKHFTIESHPLLYRHTMGSKIANVIFEKLYSRIDFNKEQYISFIKDAFLHFYNYSKRYAINENIAKDAVTNNIALMSTFYDSDNTSGEVLNNDFTEESFETALDVEHTIVGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DY3</accession>
    <name>Q32DY3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_2398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403963.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DY3"/>
    <dbReference type="STRING" id="300267.SDY_2398"/>
    <dbReference type="EnsemblBacteria" id="ABB62472">
        <property type="protein sequence ID" value="ABB62472"/>
        <property type="gene ID" value="SDY_2398"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2398"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2891"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="9879" checksum="E895AA8966B91FD4" modified="2005-12-06" version="1">MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVSLNTILHHLKNSGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EB2</accession>
    <name>Q32EB2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactitol-1-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gatD</name>
        <name evidence="4" type="ordered locus">SDY_2263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000844242.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403834.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EB2"/>
    <dbReference type="STRING" id="300267.SDY_2263"/>
    <dbReference type="EnsemblBacteria" id="ABB62343">
        <property type="protein sequence ID" value="ABB62343"/>
        <property type="gene ID" value="SDY_2263"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2263"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2732"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_6"/>
    <dbReference type="OMA" id="AYCYSTE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="6"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="346" mass="37392" checksum="1587A1C63EEF1C5C" modified="2005-12-06" version="1">MKSVVNDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLPRIFKNGAHYYPITLGHEFSGYIDAVGSGVDDLHPSDAVACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEYIVVKRNNVFALPADMPIEDGAFIEPITVGLHAFHLAQGCENKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDISSEKLSLAKSFGAMQTFNSSEMSAPQMQSVLRELRFNQLILETAGVPQTVELAVEIAGPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGSWMNYSSPWPGQEWETASRLLTERKLSLEPLIAHRGSFESFAQAVRDIARNAMPGKVLLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ED5</accession>
    <name>Q32ED5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0265 protein YeeX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">yeeX</name>
        <name evidence="4" type="ordered locus">SDY_2237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0265 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403811.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ED5"/>
    <dbReference type="STRING" id="300267.SDY_2237"/>
    <dbReference type="EnsemblBacteria" id="ABB62320">
        <property type="protein sequence ID" value="ABB62320"/>
        <property type="gene ID" value="SDY_2237"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2237"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2706"/>
    <dbReference type="HOGENOM" id="CLU_153146_0_0_6"/>
    <dbReference type="OMA" id="IANMRSD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00683">
        <property type="entry name" value="UPF0265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007458">
        <property type="entry name" value="DUF496"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39591">
        <property type="entry name" value="PTHR39591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04363">
        <property type="entry name" value="DUF496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028773">
        <property type="entry name" value="UCP028773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15163" checksum="E32BCD33B89B1A9E" modified="2005-12-06" version="1">MLALTNSGCLNESDSHIIRGIKMETTKPSFQDVLEFVRLFRRKNKLQREIQDVEKKIRDNQKRVLLLDNLSDYIKPGMSVEAIQGIITSMKGDYEDRVDDYIIKNAELSKERRDISKKLKAMGEMKNGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ET2</accession>
    <name>Q32ET2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Negative regulator of flagellin synthesis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Anti-sigma-28 factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">flgM</name>
        <name evidence="11" type="ordered locus">SDY_2081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000020884.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403664.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ET2"/>
    <dbReference type="STRING" id="300267.SDY_2081"/>
    <dbReference type="EnsemblBacteria" id="ABB62173">
        <property type="protein sequence ID" value="ABB62173"/>
        <property type="gene ID" value="SDY_2081"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2081"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2502"/>
    <dbReference type="HOGENOM" id="CLU_149304_2_2_6"/>
    <dbReference type="OMA" id="QSKLMQP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035890">
        <property type="entry name" value="Anti-sigma-28_factor_FlgM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007412">
        <property type="entry name" value="FlgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031316">
        <property type="entry name" value="FlgM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04316">
        <property type="entry name" value="FlgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101498">
        <property type="entry name" value="SSF101498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03824">
        <property type="entry name" value="FlgM_jcvi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FlgM" evidence="10">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="97" mass="10355" checksum="30A0B463324FE34D" modified="2005-12-06" version="1">MSIDRTSPLKPVSTVQPRETTDAPVTNTRAAKTTASTSTSVTLSDAQAKLMQPGSSDINLERVEALKLAIRNGELKMDTGKIADALINEAQQDLQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EX3</accession>
    <name>Q32EX3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ycfS</name>
        <name evidence="9" type="ordered locus">SDY_2037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001312748.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403623.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EX3"/>
    <dbReference type="STRING" id="300267.SDY_2037"/>
    <dbReference type="MEROPS" id="C82.A05"/>
    <dbReference type="EnsemblBacteria" id="ABB62132">
        <property type="protein sequence ID" value="ABB62132"/>
        <property type="gene ID" value="SDY_2037"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2037"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2451"/>
    <dbReference type="HOGENOM" id="CLU_046834_0_0_6"/>
    <dbReference type="OMA" id="IKDPTWT"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041597">
        <property type="entry name" value="Ldt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17969">
        <property type="entry name" value="Ldt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220947" description="LysM domain-containing protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="8">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="320" mass="34619" checksum="8939906C520D6EF7" modified="2005-12-06" version="1">MMIKTRFSRWLTFFTFAAAVALALPAKANTWPLPPAGSRLVGENKFHVVENDGGSLEAIAKKYNVGFLALLQANPGVDPYVPRAGSVLTIPLQTLLPDAPREGIVINIAELRLYYYPPGKNSVTVYPIGIGQLGGDTLTPTMVTTVSDKRANPTWTPTANIRARYKAQGIELPAVVPAGPDNPMGHHAIRLAAYGGVYLLHGTNADFGIGMRVSSGCIRLRDDDIKTLFSQVTPGTKVNIINTPIKVSAEPNGARLVEVHQPLSEKIDDDPQLLPITLNSAMQSFKNAAQTDAEVMQHVMDVRSGMPVDVRRHQVSPQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F07</accession>
    <name>Q32F07_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ipaH_5</name>
        <name evidence="13" type="ordered locus">SDY_2003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LRR-containing bacterial E3 ligase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022148.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403589.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F07"/>
    <dbReference type="SMR" id="Q32F07"/>
    <dbReference type="EnsemblBacteria" id="ABB62098">
        <property type="protein sequence ID" value="ABB62098"/>
        <property type="gene ID" value="SDY_2003"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2003"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2414"/>
    <dbReference type="HOGENOM" id="CLU_018533_2_0_6"/>
    <dbReference type="OMA" id="LWVSHNQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032674">
        <property type="entry name" value="LRR_E3_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029487">
        <property type="entry name" value="NEL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14496">
        <property type="entry name" value="NEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12468">
        <property type="entry name" value="TTSSLRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="TTSSLRR" evidence="11">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="NEL" evidence="12">
        <location>
            <begin position="299"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB62098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="583" mass="65950" checksum="421922499AB9D927" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FA6</accession>
    <name>Q32FA6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000534306.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403490.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FA6"/>
    <dbReference type="STRING" id="300267.SDY_1891"/>
    <dbReference type="EnsemblBacteria" id="ABB61999">
        <property type="protein sequence ID" value="ABB61999"/>
        <property type="gene ID" value="SDY_1891"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1891"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2276"/>
    <dbReference type="HOGENOM" id="CLU_656797_0_0_6"/>
    <dbReference type="OMA" id="ACNCEIN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030930">
        <property type="entry name" value="AIDA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004899">
        <property type="entry name" value="Pertactin_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16168">
        <property type="entry name" value="AIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03212">
        <property type="entry name" value="Pertactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04415">
        <property type="entry name" value="O_hepto_targRPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pertactin" evidence="1">
        <location>
            <begin position="336"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="418" mass="42807" checksum="4E17A25CE37EE5C5" modified="2005-12-06" version="1">MGSDAKNLMSDGNVQIVKTGEVIGATQLTEGELIVEAGGRAENTVVTGAGWLKVTTGGIAKCTQYGNNGTLSVSDGAIATDIVQSEGGAISLSTLATVNGRHPEGEFSVDKGYACGLLLENGGNLRVLEGHRAEKIILDQEGGLLVNGTTSAVVVDEGGELLVYPGGEASNCEINQGGVFMLAGKANDTLLAGGTMNNLGGEDSDTIVENGAIYRLGTDGLQLYSSGKTQNLSVNVGGRAEVHAGTLENAVIQGGTVILLSPTSADENFVVEEDRAPVELTGSVALLDGASMIIGYGADLQQSTITVQQGGVLILDGSTVKGDSVTFSIGNSNLNGGKLWLITGAATHVQLKVKRLRGEGAICLQTSAKEISPDFINVKGEVTGDIHVEITDASRQTLCNALKLQPDEDGIGATLQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FF1</accession>
    <name>Q32FF1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MalY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">malY</name>
        <name evidence="2" type="ordered locus">SDY_1845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000459375.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403445.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FF1"/>
    <dbReference type="STRING" id="300267.SDY_1845"/>
    <dbReference type="EnsemblBacteria" id="ABB61954">
        <property type="protein sequence ID" value="ABB61954"/>
        <property type="gene ID" value="SDY_1845"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1845"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2224"/>
    <dbReference type="HOGENOM" id="CLU_017584_15_0_6"/>
    <dbReference type="OMA" id="NEVCDVN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="390" mass="43552" checksum="0EFFAF1747586602" modified="2005-12-06" version="1">MFDFSKVVDRHGTWCTQWDYVADRFGTADLLPFTISDMDFATAPCIIEALNQRLMHGVFGYSRWKNDEFLAAIAHWFSTQHYTAIDPQSVVYGPSVIYMVSELIRQWSETGEGVVIHTPAYDAFYKAIEGNQRTVMPVALEKQADGWFCDMGKLEAVLAKPECKIMLLCSPQNPTGKVWTCDELEIMADLCERHGVRVISDEIHMDMVWGEQPHIPWSNVARGDWALLTSGSKSFNIPALTGAYGIIENSSSRDAYLSALKGRDGLSSPSVLALTAHIAAYQQGAPWLDALRVYLKDNLTYIADKMNAAFPELNWQIPQSTYLAWLDLRPLNIDDNALQKALIGKEKVAIMPGYTYGEEGRGFVRLNAGCPRSKLEKGVAGLINAIRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FI9</accession>
    <name>Q32FI9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin/glutathione peroxidase BtuE</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
            <ecNumber evidence="3">1.11.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">btuE</name>
        <name evidence="6" type="ordered locus">SDY_1805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutathione peroxidase family. BtuE subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EC" id="1.11.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001154187.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403407.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FI9"/>
    <dbReference type="SMR" id="Q32FI9"/>
    <dbReference type="STRING" id="300267.SDY_1805"/>
    <dbReference type="EnsemblBacteria" id="ABB61916">
        <property type="protein sequence ID" value="ABB61916"/>
        <property type="gene ID" value="SDY_1805"/>
    </dbReference>
    <dbReference type="GeneID" id="66674396"/>
    <dbReference type="KEGG" id="sdy:SDY_1805"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2177"/>
    <dbReference type="HOGENOM" id="CLU_029507_1_2_6"/>
    <dbReference type="OMA" id="LAPFKGQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02061">
        <property type="entry name" value="Thiored_glutath_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033674">
        <property type="entry name" value="BtuE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 3 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="183" mass="20410" checksum="FBD5659D3067FA92" modified="2005-12-06" version="1">MQDSILTTVVKDIDGEVTTLEKYAGNVLLIVNVASKCGLTPQYEQLENIQKAWADRGFVVLGFPCNQFLEQEPGSDEEIKTYCTTTWGVTFPMFSKIEVNGEGRHPLYQKLIAAAPTAVAPEESGFYARMVSKGRAPLYPDDILWNFEKFLVGRDGLVIQRFSPDMTPEDPIVMESIKLALAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G65</accession>
    <name>MDTI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spermidine export protein MdtI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mdtI</name>
        <name type="ordered locus">SDY_1554</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the excretion of spermidine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with MdtJ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000046670.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403181.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G65"/>
    <dbReference type="SMR" id="Q32G65"/>
    <dbReference type="STRING" id="300267.SDY_1554"/>
    <dbReference type="EnsemblBacteria" id="ABB61690">
        <property type="protein sequence ID" value="ABB61690"/>
        <property type="gene ID" value="SDY_1554"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1554"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1863"/>
    <dbReference type="HOGENOM" id="CLU_133067_0_4_6"/>
    <dbReference type="OMA" id="VAAGWIM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042221">
        <property type="term" value="P:response to chemical"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01597">
        <property type="entry name" value="MdtI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023737">
        <property type="entry name" value="Spermidine_export_MdtI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561:SF6">
        <property type="entry name" value="PTHR30561:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000331152" description="Spermidine export protein MdtI">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01597"/>
        </source>
    </evidence>
    <sequence length="109" mass="11765" checksum="3EAF6189BD47BF76" modified="2005-12-06" version="1">MAQFEWVHAAWLALAIVLEIVANVFLKFSDGFRRKIFGLLSQAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAGWILFGQRLNRKGWIGLVLLLAGMIMVKLT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GL1</accession>
    <name>YCJF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0283 membrane protein YcjF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycjF</name>
        <name type="ordered locus">SDY_1400</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0283 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000138724.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403035.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GL1"/>
    <dbReference type="STRING" id="300267.SDY_1400"/>
    <dbReference type="EnsemblBacteria" id="ABB61544">
        <property type="protein sequence ID" value="ABB61544"/>
        <property type="gene ID" value="SDY_1400"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1400"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1661"/>
    <dbReference type="HOGENOM" id="CLU_057693_2_0_6"/>
    <dbReference type="OMA" id="MFFIAWR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01085">
        <property type="entry name" value="UPF0283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021147">
        <property type="entry name" value="DUF697"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006507">
        <property type="entry name" value="UPF0283"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39342">
        <property type="entry name" value="PTHR39342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05128">
        <property type="entry name" value="DUF697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01620">
        <property type="entry name" value="hyp_HI0043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000064851" description="UPF0283 membrane protein YcjF">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01085"/>
        </source>
    </evidence>
    <sequence length="344" mass="38353" checksum="E085542F1103AA99" modified="2005-12-06" version="1">MTEPLKPRIDFDGPLEVDQNPKFRAQQTFDENQAQNFAPATLDEAQEEEGQVEAVMDAALRPKRSLWRKMVMGGLALFGASVVGQGVQWTMNACQTQDWVALGGCAAGALIIGAGVGSVVTEWRRLWRLRQRAHERDEARDLLHSHGTGKGRVFCEKLAQQAGIDQSHPALQRWYASIHETQNDREVVSLYAHLVQPVLDAQARREISRSAAESTLMIAVSPLALVDMAFIAWRNLRLINRIATLYGIELGYYSRLRLFKLVLLNIAFAGASELVREVGMDWMSQDLAARLSTRAAQGIGAGLLTARLGIKAMELCRPLPWIDDDKPRLGDFRRQLIGQVKETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GQ4</accession>
    <name>Q32GQ4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipopolysaccharide assembly protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yciS</name>
        <name evidence="5" type="synonym">lapA</name>
        <name evidence="7" type="ordered locus">SDY_1355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the assembly of lipopolysaccharide (LPS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the LapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000876292.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402992.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GQ4"/>
    <dbReference type="STRING" id="300267.SDY_1355"/>
    <dbReference type="EnsemblBacteria" id="ABB61501">
        <property type="protein sequence ID" value="ABB61501"/>
        <property type="gene ID" value="SDY_1355"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1355"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1605"/>
    <dbReference type="HOGENOM" id="CLU_160072_0_0_6"/>
    <dbReference type="OMA" id="QGDYRIS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008653">
        <property type="term" value="P:lipopolysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01948">
        <property type="entry name" value="LPS_assembly_LapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032906">
        <property type="entry name" value="LapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010445">
        <property type="entry name" value="LapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06305">
        <property type="entry name" value="LapA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="LapA_dom" evidence="6">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="102" mass="11411" checksum="DA7C2881E2E2FB8C" modified="2005-12-06" version="1">MKYLLIFLLVLAIFVISVTLGAQNDQQVTFNYLLAQGEYRISTLLAVLFAAGFAIGWLICGLFWLRVRVSLVRAERKIKRLENQLSPATDVAVVQHSSAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GU9</accession>
    <name>Q32GU9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yciI</name>
        <name evidence="3" type="ordered locus">SDY_1309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GU9"/>
    <dbReference type="STRING" id="300267.SDY_1309"/>
    <dbReference type="EnsemblBacteria" id="ABB61456">
        <property type="protein sequence ID" value="ABB61456"/>
        <property type="gene ID" value="SDY_1309"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1309"/>
    <dbReference type="HOGENOM" id="CLU_110355_3_0_6"/>
    <dbReference type="OMA" id="ARAWVND"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="34"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="130" mass="14109" checksum="3CDA6F99F5FDD7E0" modified="2005-12-06" version="1">MHGLNKDIIFPLQIFALSNNVLYNFPEQGVVPVLYVIYAQDNADSLAKRLSVRPAHLARLQLLHDEGRLLTAGPMPAVDSNDPGAAGFTGSTVIAEFESLEAAQAWADADPYVAAGVYEHVSVKPFKKVF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GV1</accession>
    <name>CLSA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cardiolipin synthase A</fullName>
            <shortName evidence="1">CL synthase</shortName>
            <ecNumber evidence="1">2.7.8.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clsA</name>
        <name type="synonym">cls</name>
        <name type="ordered locus">SDY_1307</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol</text>
            <dbReference type="Rhea" id="RHEA:31451"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000214509.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402945.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GV1"/>
    <dbReference type="SMR" id="Q32GV1"/>
    <dbReference type="STRING" id="300267.SDY_1307"/>
    <dbReference type="EnsemblBacteria" id="ABB61454">
        <property type="protein sequence ID" value="ABB61454"/>
        <property type="gene ID" value="SDY_1307"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1307"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1553"/>
    <dbReference type="HOGENOM" id="CLU_038053_1_0_6"/>
    <dbReference type="OMA" id="TRFILDW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00190">
        <property type="entry name" value="Cardiolipin_synth_ClsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030840">
        <property type="entry name" value="CL_synthase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000058494" description="Cardiolipin synthase A">
        <location>
            <begin position="1"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase 1" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase 2" evidence="1">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00190"/>
        </source>
    </evidence>
    <sequence length="486" mass="54856" checksum="585F4AF094D560EE" modified="2005-12-06" version="1">MTTVYTLVSWLAILGYWLLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLAVGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAEENSSVAAPLFKLCERRQGIAGVKGNQLQLMTESDDVMQALIRDIQLARHNIEMVFYIWKPGGMADQVAESLMAAARRGIHCRLMLDSAGSVAFFRSPWPELMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMIMIDNYIAYTGSMNMVDPRYFKQDAGVGQWIDLMARMEGPIATAMGIIYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDLIHQALLTAAYSAREYLIMTTPYFVPSDDLFHAICTAAQRGVDVSIILPRKNDSMLVGWASRAFFTELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLAIDDKGFGADLAAVQDDYISRSRLLDARLWLKRPLWQRVAERLFYFFSPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GZ1</accession>
    <name>Q32GZ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402905.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GZ1"/>
    <dbReference type="EnsemblBacteria" id="ABB61414">
        <property type="protein sequence ID" value="ABB61414"/>
        <property type="gene ID" value="SDY_1265"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1265"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1502"/>
    <dbReference type="HOGENOM" id="CLU_212598_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025253">
        <property type="entry name" value="Toxin_Ldr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13940">
        <property type="entry name" value="Ldr_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="44" mass="4990" checksum="A90F33E6CF969E02" modified="2005-12-06" version="1">MLSLQQGGYMTLAQFAMIFWHDLAAPILAGIITVAIVGWWRNRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GZ2</accession>
    <name>KDSA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-dehydro-3-deoxyphosphooctonate aldolase</fullName>
            <ecNumber evidence="1">2.5.1.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">3-deoxy-D-manno-octulosonic acid 8-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">KDO-8-phosphate synthase</fullName>
            <shortName evidence="1">KDO 8-P synthase</shortName>
            <shortName evidence="1">KDOPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phospho-2-dehydro-3-deoxyoctonate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kdsA</name>
        <name type="ordered locus">SDY_1264</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14053"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57693"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="EC" id="2.5.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KdsA family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.55" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000811065.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402904.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GZ2"/>
    <dbReference type="SMR" id="Q32GZ2"/>
    <dbReference type="STRING" id="300267.SDY_1264"/>
    <dbReference type="EnsemblBacteria" id="ABB61413">
        <property type="protein sequence ID" value="ABB61413"/>
        <property type="gene ID" value="SDY_1264"/>
    </dbReference>
    <dbReference type="GeneID" id="66674965"/>
    <dbReference type="KEGG" id="sdy:SDY_1264"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1501"/>
    <dbReference type="HOGENOM" id="CLU_036666_0_0_6"/>
    <dbReference type="OMA" id="FRGIPTM"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00357">
        <property type="reaction ID" value="UER00474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008676">
        <property type="term" value="F:3-deoxy-8-phosphooctulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019294">
        <property type="term" value="P:keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00056">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006269">
        <property type="entry name" value="KDO8P_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21057">
        <property type="entry name" value="PTHR21057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01362">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000304492" description="2-dehydro-3-deoxyphosphooctonate aldolase">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00056"/>
        </source>
    </evidence>
    <sequence length="284" mass="30833" checksum="35E79D692D134535" modified="2005-12-06" version="1">MKQKVVSIGDINVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQTFGVKIITDVHEPSQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFKEGGNEKVILCDRGANFGYDNLVVDMLGFSIMKKVSGNSPVIFDVTHALQCRDPFGAASGGRRAQVAELARAGMAVGLAGLFIEAHPDPEHAKCDGPSALPLAKLEPFLKQMKAIDDLVKGFEELDTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H05</accession>
    <name>Q32H05_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402891.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H05"/>
    <dbReference type="EnsemblBacteria" id="ABB61400">
        <property type="protein sequence ID" value="ABB61400"/>
        <property type="gene ID" value="SDY_1251"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1251"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1487"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15352" checksum="E34B644E99B6AF1B" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQWIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HE7</accession>
    <name>Q32HE7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative periplasmic binding transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fliY</name>
        <name evidence="7" type="ordered locus">SDY_1097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378649.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402749.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HE7"/>
    <dbReference type="STRING" id="300267.SDY_1097"/>
    <dbReference type="EnsemblBacteria" id="ABB61258">
        <property type="protein sequence ID" value="ABB61258"/>
        <property type="gene ID" value="SDY_1097"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1097"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1290"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_5_6"/>
    <dbReference type="OMA" id="QPTKWDG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="42"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="6">
        <location>
            <begin position="42"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="266" mass="29005" checksum="023748E0A34E5C56" modified="2005-12-06" version="1">MKLAHLGRQALIGVMAVALVAGMSVKSFADEGLLNKVKERGTLLVGLEGTYPPFSFQGDDGKLTGFEVEFAQQLAKHLGVEASLKPTKWDGMLASLDSKRIDVVINQVTISDERKKKYDFSTPYTISGIQALVKKGNEGTIKTAADLKGKKVGVGLGTNYEEWLRQNVQGVDVRTYDDDPTKYQDLRVGRIDAILVDRLAALDLVKKTNDTLAVTGEVFSRQESGVALRKGNEDLLKAVNDAIAEMQKDGTLQALSEKWFGADVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HJ1</accession>
    <name>Q32HJ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000009307.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402705.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HJ1"/>
    <dbReference type="SMR" id="Q32HJ1"/>
    <dbReference type="STRING" id="300267.SDY_1049"/>
    <dbReference type="EnsemblBacteria" id="ABB61214">
        <property type="protein sequence ID" value="ABB61214"/>
        <property type="gene ID" value="SDY_1049"/>
    </dbReference>
    <dbReference type="GeneID" id="66674154"/>
    <dbReference type="KEGG" id="sdy:SDY_1049"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1225"/>
    <dbReference type="HOGENOM" id="CLU_196663_0_0_6"/>
    <dbReference type="OMA" id="RMVVTGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019226">
        <property type="entry name" value="DUF2158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09926">
        <property type="entry name" value="DUF2158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="60" mass="6678" checksum="1D05C2D0FC6A68C5" modified="2005-12-06" version="1">MSFMVSEEVTVKEGGPRMIVTGYSSGMVECRWYDGYGVKREAFHETELVPGEGSRSAEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HJ7</accession>
    <name>Q32HJ7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HJ7"/>
    <dbReference type="STRING" id="300267.SDY_1043"/>
    <dbReference type="EnsemblBacteria" id="ABB61208">
        <property type="protein sequence ID" value="ABB61208"/>
        <property type="gene ID" value="SDY_1043"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1043"/>
    <dbReference type="HOGENOM" id="CLU_194635_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="9542" checksum="56B7ECFDDCC9CE5D" modified="2005-12-06" version="1">MDLQHWQAQFENWLKNHHQHQDAAHGVCHFRRVWATAQKLAADDDVDMLVILTACYFHDIVSLAKNHPQRQRSSILAAEETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HL6</accession>
    <name>Q32HL6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ferric enterochelin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iroD</name>
        <name evidence="5" type="ordered locus">SDY_1024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Fes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000933674.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402680.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HL6"/>
    <dbReference type="STRING" id="300267.SDY_1024"/>
    <dbReference type="ESTHER" id="shidy-IROD">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61189">
        <property type="protein sequence ID" value="ABB61189"/>
        <property type="gene ID" value="SDY_1024"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1024"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1197"/>
    <dbReference type="HOGENOM" id="CLU_024314_3_0_6"/>
    <dbReference type="OMA" id="GSYWWAP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008849">
        <property type="term" value="F:enterochelin esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021764">
        <property type="entry name" value="Enterochelin_esterase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11806">
        <property type="entry name" value="DUF3327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3327" evidence="4">
        <location>
            <begin position="52"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="409" mass="44749" checksum="6E061B80D727258B" modified="2005-12-06" version="1">MLNMQQHPSAIASLRNQLAAGHIANLTDFWREAESLNVPLVTPVEGAEDEREVTFLWRARHPLQGVYLRLNRVTDKEHVEKGMMSALPETDIWTLTLRLPASYCGSYSLLEIPPGTTAETIALSGGRFATLAGKADPLNKMPEINVRGNAKESVLTLDKAPALSEWNGGFHTGQLLTSMRIIAGKSRQVRLYIPDVDISQPLGLVVLPDGETWFDHLGVCAAIDAAINNGRIVPVAVLGIDNINEHERTEILGGRSKLIKDIAEHLLPMIRAEQPQRQWADRSRTVLAGQSLGGISALMGARYAPETFGLVLSHSPSMWWTPERTSRPSLFSETDTSWVSEHLLSAPPQGVRISLCVGSLEGSTVPHVQQLHQRLITAGVESHCAIYTGGHDYAWWRGALIDGIGLLQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HQ4</accession>
    <name>RUTF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN reductase (NADH) RutF</fullName>
            <ecNumber evidence="1">1.5.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FMN reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NADH-flavin reductase RutF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NADH:flavin oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rutF</name>
        <name type="ordered locus">SDY_0982</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>FMNH2 + NAD(+) = FMN + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:21620"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.5.1.42"/>
        </reaction>
    </comment>
    <comment type="induction">
        <text evidence="1">Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.42" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402642.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HQ4"/>
    <dbReference type="SMR" id="Q32HQ4"/>
    <dbReference type="STRING" id="300267.SDY_0982"/>
    <dbReference type="EnsemblBacteria" id="ABB61151">
        <property type="protein sequence ID" value="ABB61151"/>
        <property type="gene ID" value="SDY_0982"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0982"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1142"/>
    <dbReference type="HOGENOM" id="CLU_059021_2_2_6"/>
    <dbReference type="OMA" id="WFDRGYH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052874">
        <property type="term" value="F:FMN reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008752">
        <property type="term" value="F:FMN reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00833">
        <property type="entry name" value="RutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019917">
        <property type="entry name" value="RutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03615">
        <property type="entry name" value="RutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000403043" description="FMN reductase (NADH) RutF">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00833"/>
        </source>
    </evidence>
    <sequence length="152" mass="16328" checksum="E97696311A66CA34" modified="2005-12-06" version="1">MSCMGAAVNIITTDGPAGRAGFTASAVCSVTDTPPTLLVCLNRGASVWPVFNENRTLCVNTLSAGQEPLSNLFGGKTPMEHRFAAARWQTGVTGCPQLEEALVSFDCRISQVVSVGTHDILFCAIEAIHRHATPYGLVWFDRSYHALMRPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HR6</accession>
    <name>Q32HR6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TorT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">torT</name>
        <name evidence="3" type="ordered locus">SDY_0968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001264923.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402630.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HR6"/>
    <dbReference type="STRING" id="300267.SDY_0968"/>
    <dbReference type="EnsemblBacteria" id="ABB61139">
        <property type="protein sequence ID" value="ABB61139"/>
        <property type="gene ID" value="SDY_0968"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0968"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1119"/>
    <dbReference type="HOGENOM" id="CLU_053104_0_0_6"/>
    <dbReference type="OMA" id="ISQIEDC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014301">
        <property type="entry name" value="TMAO_TorT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02955">
        <property type="entry name" value="TMAO_TorT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220757" evidence="1">
        <location>
            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="342" mass="37895" checksum="DF73A07BB653CAB9" modified="2005-12-06" version="1">MRVLLFLLLSLFMLPAFSADNLLRWHDAQHFTVQASMPLKAKRAWKLCALYPSLKDSYWLSLNYGMQEAARRYGVDLKVLEAGGYSQLATQQAQIDQCKQWGAEAILLGSSTTSFPDLQKQVASLPVIELVNALDAPQVKSRVGVPWFQMGYQPGRYLVQWAHGKPLNVLLMPGPDNAGGSKEMVEGFRAAIAGSPVRIVDIALGDNDIEIQRNLLQEMLERHPEIDVVAGTAIAAEAAMGEGRNLKTPLTVVSFYLSHQVYRGLKRGRVIMAASDQMVWQGELAVEQAIRQLQGQSVSDNVSPPILVLTPKNADREHIRRSLSPGGFRPVYFYQHTSAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HS6</accession>
    <name>Q32HS6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">yccC</name>
        <name evidence="20" type="ordered locus">SDY_0957</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the etk/wzc family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000208681.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402620.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HS6"/>
    <dbReference type="STRING" id="300267.SDY_0957"/>
    <dbReference type="EnsemblBacteria" id="ABB61129">
        <property type="protein sequence ID" value="ABB61129"/>
        <property type="gene ID" value="SDY_0957"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0957"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1105"/>
    <dbReference type="HOGENOM" id="CLU_009912_0_0_6"/>
    <dbReference type="OMA" id="VYGPKHP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="17">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="19">
        <location>
            <begin position="367"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="18">
        <location>
            <begin position="543"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ABB61129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="726" mass="81402" checksum="E219A3DA913F299D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HT1</accession>
    <name>Q32HT1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Processor of HyaA and HyaB proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hyaE</name>
        <name evidence="2" type="ordered locus">SDY_0951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupG/HyaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000063968.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402615.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HT1"/>
    <dbReference type="STRING" id="300267.SDY_0951"/>
    <dbReference type="EnsemblBacteria" id="ABB61124">
        <property type="protein sequence ID" value="ABB61124"/>
        <property type="gene ID" value="SDY_0951"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0951"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1098"/>
    <dbReference type="HOGENOM" id="CLU_144855_1_0_6"/>
    <dbReference type="OMA" id="WHIAMAD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02965">
        <property type="entry name" value="HyaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010893">
        <property type="entry name" value="NiFe-hyd_mat_HyaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07449">
        <property type="entry name" value="HyaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="132" mass="14897" checksum="DA3D09045D5B6A5A" modified="2005-12-06" version="1">MSNDTPFDALWQRMLARGWTPVSEFRLDDWLTQAPDGVVLLSSDPKRTPEVSDNPVMIGELLREFPDYTWQVAIADLEQSEAIGDRFGVFRFPATLVFTGGNYCGVLNGIHPWAELINLMRGLVEPQQERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HY2</accession>
    <name>Q32HY2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">bcr</name>
        <name evidence="10" type="ordered locus">SDY_0897</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000213352.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402564.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HY2"/>
    <dbReference type="STRING" id="300267.SDY_0897"/>
    <dbReference type="EnsemblBacteria" id="ABB61073">
        <property type="protein sequence ID" value="ABB61073"/>
        <property type="gene ID" value="SDY_0897"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0897"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1038"/>
    <dbReference type="HOGENOM" id="CLU_001265_47_0_6"/>
    <dbReference type="OMA" id="YFFMLNI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004734">
        <property type="entry name" value="Multidrug-R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="11"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="396" mass="43369" checksum="E252931B7FD5EE9E" modified="2005-12-06" version="1">MTTRQHSSFAIVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSTQMTLSTYILGFALGQLIFGPMADSFGRKPVVLGGTLVFAAAAVACALAQTIDQLIVMRFFHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLMAPIVGGWVLVWLSWHYIFWILAVAAILASAMIFFLIKETLPLERRQLFHIRTTIGNFAALFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIEINHVAPENFGYYFALNIVFLFVMTIFNSRFVRRIGALNMFRSGLWIQFIMAAWMVISALLGLGFWSLVVGVAAFVGCVSMVSSNAMAVILDEFPHMAGTASSLAGTFRFGIGAIVGALLSLATFNSAWPMIWSIAFCATSSILFCLYASRPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I20</accession>
    <name>Q32I20_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein RcsB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">rcsB</name>
        <name evidence="6" type="ordered locus">SDY_0857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with RcsD and RcsA.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Phosphorylated and activated by RcsD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RcsB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001061917.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402526.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I20"/>
    <dbReference type="SMR" id="Q32I20"/>
    <dbReference type="STRING" id="300267.SDY_0857"/>
    <dbReference type="EnsemblBacteria" id="ABB61035">
        <property type="protein sequence ID" value="ABB61035"/>
        <property type="gene ID" value="SDY_0857"/>
    </dbReference>
    <dbReference type="GeneID" id="67373623"/>
    <dbReference type="KEGG" id="sdy:SDY_0857"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.991"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_6"/>
    <dbReference type="OMA" id="TITMIDN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00981">
        <property type="entry name" value="RcsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030864">
        <property type="entry name" value="RcsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2 3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="216" mass="23671" checksum="A78D1BD3004E0680" modified="2005-12-06" version="1">MNNMNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGDKYGDGITLIKYIKRHFPSLSIIVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPESVSRLLEKISAGGYGDKRLSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLNYLSSVTLSPADKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I37</accession>
    <name>Q32I37_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yliJ</name>
        <name evidence="4" type="ordered locus">SDY_0838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402509.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I37"/>
    <dbReference type="STRING" id="300267.SDY_0838"/>
    <dbReference type="EnsemblBacteria" id="ABB61020">
        <property type="protein sequence ID" value="ABB61020"/>
        <property type="gene ID" value="SDY_0838"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0838"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.965"/>
    <dbReference type="HOGENOM" id="CLU_011226_6_2_6"/>
    <dbReference type="OMA" id="LWQKAFE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="90"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="210" mass="23958" checksum="BF79E55EB2822235" modified="2005-12-06" version="1">MSMITLWGRNNSTNVKKVLLTLEELELPYEQILAGREFGINHDADFLAMNPNGLVPLLRDDESDLILWESNAIVRYLAAQYGQKRLWIDSPARRAEAEKWMDWANQTLSNAHRGILMGLVRTPPEERDQAAIDARCKECDALFALLDAELAKVKWFSGDEFGVGDIAIAPFIYNLFNVGLTWTPPPNLQRWYQQLTERPAVRKVVMILVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ID0</accession>
    <name>RIMK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein S6--L-glutamate ligase</fullName>
            <ecNumber evidence="1">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Poly-alpha-glutamate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosomal protein S6 modification protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimK</name>
        <name type="ordered locus">SDY_0743</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimK family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000684321.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402416.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ID0"/>
    <dbReference type="SMR" id="Q32ID0"/>
    <dbReference type="STRING" id="300267.SDY_0743"/>
    <dbReference type="EnsemblBacteria" id="ABB60927">
        <property type="protein sequence ID" value="ABB60927"/>
        <property type="gene ID" value="SDY_0743"/>
    </dbReference>
    <dbReference type="GeneID" id="58460667"/>
    <dbReference type="KEGG" id="sdy:SDY_0743"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.857"/>
    <dbReference type="HOGENOM" id="CLU_054353_0_1_6"/>
    <dbReference type="OMA" id="CYMNIAS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018169">
        <property type="term" value="F:ribosomal S6-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018410">
        <property type="term" value="P:C-terminal protein amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01552">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023533">
        <property type="entry name" value="RimK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041107">
        <property type="entry name" value="Rimk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18030">
        <property type="entry name" value="Rimk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000068858" description="Ribosomal protein S6--L-glutamate ligase">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="1">
        <location>
            <begin position="104"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01552"/>
        </source>
    </evidence>
    <sequence length="300" mass="32436" checksum="C0AF021292ED41DD" modified="2005-12-06" version="1">MKIAILSRDGTLYSCKRLREAAIQRGHLVEILDPLSCYMNINPAASSIHYKGRKLPHFDAVIPRIGTAITFYGTAALRQFEMLGSYPLNESVAIARARDKLRSMQLLARQGIDLPVTGIAHSPDDTSDLIDMVGGAPLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNAHILVQEYIKEAQGCDIRCLVVGDEVVAAIERRAKEGDFRSNLHRGGAASVASITPQEREIAIKAARTMALDVAGVDILRANRGPLVMEVNASPGLEGIEKTTGIDIAGKMIRWIERHATTEYCLKTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IG9</accession>
    <name>Q32IG9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">galM</name>
        <name evidence="11" type="ordered locus">SDY_0703</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000931374.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402377.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IG9"/>
    <dbReference type="STRING" id="300267.SDY_0703"/>
    <dbReference type="EnsemblBacteria" id="ABB60888">
        <property type="protein sequence ID" value="ABB60888"/>
        <property type="gene ID" value="SDY_0703"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0703"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.814"/>
    <dbReference type="HOGENOM" id="CLU_031753_1_0_6"/>
    <dbReference type="OMA" id="ATWLSCK"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013458">
        <property type="entry name" value="Ald_epimerase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02636">
        <property type="entry name" value="galM_Leloir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="346" mass="38108" checksum="DB243739BFAF0B7E" modified="2005-12-06" version="1">MLNETPALAPDGQPYRLLTLRNNAGMVATLMDWGATLLSARIPLSDGSVREALLGCASPECYQDQAAFLGASIGRYANRIANSCYTFDGETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQNDRQVLFALSSDDGDQGFPGNLGATVQYRLTDDNRISITYRATVDKPCPVNMTNHVYFNLDGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRKVKGYDHAFLLQAKGNGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPYADWQGLALESEFLPDSPNHPEWPQPDCFLRPGEEYSSLTEYQFIAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IJ3</accession>
    <name>GMSS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate mutase sigma subunit</fullName>
            <ecNumber evidence="1">5.4.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate mutase S chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamate mutase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methylaspartate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmS</name>
        <name type="ordered locus">SDY_0676</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-3-methyl-L-aspartate = L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12857"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="5.4.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylaspartate mutase GlmS subunit family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60864" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60864.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000710390.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402353.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IJ3"/>
    <dbReference type="SMR" id="Q32IJ3"/>
    <dbReference type="STRING" id="300267.SDY_0676"/>
    <dbReference type="EnsemblBacteria" id="ABB60864">
        <property type="protein sequence ID" value="ABB60864"/>
        <property type="gene ID" value="SDY_0676"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0676"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.789"/>
    <dbReference type="HOGENOM" id="CLU_136705_0_0_6"/>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02072">
        <property type="entry name" value="Glm_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00526">
        <property type="entry name" value="Me_Asp_mutase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006394">
        <property type="entry name" value="GlmS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01501">
        <property type="entry name" value="MthylAspMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0846">Cobalamin</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264143" description="Glutamate mutase sigma subunit">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="149" mass="16430" checksum="B785DAE49F27D9D0" modified="2006-12-12" version="2">MKKATLVIGVIGADCHAVGNKVLDRVFSNHDFRVINLGVMVSQDEYIDAAIETGADAIVVSSIYGHGDIDCLGMRERCIERGLGDILLYVGGNLVVGKHDFADVETKFKEMGFDRVFAPSHDLEDVCQLMAHDINQRHDVDTRILEEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IU5</accession>
    <name>Q32IU5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidoglycan D,D-transpeptidase MrdA</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Penicillin-binding protein 2</fullName>
            <shortName evidence="3">PBP-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">mrdA</name>
        <name evidence="6" type="ordered locus">SDY_0557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes cross-linking of the peptidoglycan cell wall.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transpeptidase family. MrdA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000776193.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402251.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IU5"/>
    <dbReference type="STRING" id="300267.SDY_0557"/>
    <dbReference type="EnsemblBacteria" id="ABB60762">
        <property type="protein sequence ID" value="ABB60762"/>
        <property type="gene ID" value="SDY_0557"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0557"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.659"/>
    <dbReference type="HOGENOM" id="CLU_009289_1_2_6"/>
    <dbReference type="OMA" id="SCDTYYY"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02081">
        <property type="entry name" value="MrdA_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="64"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="272"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="633" mass="70847" checksum="D1F1F8EFD08BEAF5" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J73</accession>
    <name>Q32J73_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J73"/>
    <dbReference type="STRING" id="300267.SDY_0423"/>
    <dbReference type="EnsemblBacteria" id="ABB60634">
        <property type="protein sequence ID" value="ABB60634"/>
        <property type="gene ID" value="SDY_0423"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0423"/>
    <dbReference type="HOGENOM" id="CLU_247992_0_0_6"/>
    <dbReference type="OMA" id="YGHFTIG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="162"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="270"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="359"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="567"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="895"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1315" mass="129072" checksum="65E8E5ED115B1B40" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JF5</accession>
    <name>Q32JF5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JF5"/>
    <dbReference type="EnsemblBacteria" id="ABB60552">
        <property type="protein sequence ID" value="ABB60552"/>
        <property type="gene ID" value="SDY_0333"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0333"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8420" checksum="D699892254034C1D" modified="2005-12-06" version="1">MITSDDWGSYGREVPKDKHLTGEIFTQRIERNNLTLRTRIKCLARKTICFSRSVESHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JG2</accession>
    <name>Q32JG2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">secD</name>
        <name evidence="11" type="ordered locus">SDY_0326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000934822.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402034.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JG2"/>
    <dbReference type="SMR" id="Q32JG2"/>
    <dbReference type="STRING" id="300267.SDY_0326"/>
    <dbReference type="EnsemblBacteria" id="ABB60545">
        <property type="protein sequence ID" value="ABB60545"/>
        <property type="gene ID" value="SDY_0326"/>
    </dbReference>
    <dbReference type="GeneID" id="66671293"/>
    <dbReference type="KEGG" id="sdy:SDY_0326"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.375"/>
    <dbReference type="HOGENOM" id="CLU_007894_4_3_6"/>
    <dbReference type="OMA" id="MVVYYRL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027398">
        <property type="entry name" value="SecD-TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13721">
        <property type="entry name" value="SecD-TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="SecD-TM1" evidence="10">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="615" mass="66632" checksum="1099E6A9CC988EBE" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JG9</accession>
    <name>RISB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="1">DMRL synthase</shortName>
            <shortName evidence="1">LS</shortName>
            <shortName evidence="1">Lumazine synthase</shortName>
            <ecNumber evidence="1">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ribH</name>
        <name type="ordered locus">SDY_0319</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001021161.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402027.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JG9"/>
    <dbReference type="SMR" id="Q32JG9"/>
    <dbReference type="STRING" id="300267.SDY_0319"/>
    <dbReference type="EnsemblBacteria" id="ABB60538">
        <property type="protein sequence ID" value="ABB60538"/>
        <property type="gene ID" value="SDY_0319"/>
    </dbReference>
    <dbReference type="GeneID" id="64296781"/>
    <dbReference type="GeneID" id="67416510"/>
    <dbReference type="KEGG" id="sdy:SDY_0319"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.368"/>
    <dbReference type="HOGENOM" id="CLU_089358_1_1_6"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000040517" description="6,7-dimethyl-8-ribityllumazine synthase">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <sequence length="156" mass="16157" checksum="1F8504B2892195C7" modified="2005-12-06" version="1">MNIIEANVATPDARVAITIARFNNFINDSLLEGAIDALKRIGQVKDENITVVWVPGAYELPLAAGALAKTGKYDAVIALGTVIRGGTAHFEYVAGGASNGLAHVAQDSEIPVAFGVLTTESIEQAIERAGTKAGNKGAEAALTALEMINVLKAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JI5</accession>
    <name>Q32JI5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yajR</name>
        <name evidence="8" type="ordered locus">SDY_0303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402011.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JI5"/>
    <dbReference type="STRING" id="300267.SDY_0303"/>
    <dbReference type="EnsemblBacteria" id="ABB60522">
        <property type="protein sequence ID" value="ABB60522"/>
        <property type="gene ID" value="SDY_0303"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0303"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.348"/>
    <dbReference type="HOGENOM" id="CLU_001265_10_0_6"/>
    <dbReference type="OMA" id="LYADSFH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="456" mass="49013" checksum="AD64E488B0339309" modified="2005-12-06" version="1">MVMNDYKMTPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPNSSTHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADAGFPTAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVASTMKEPPYVSSLRIEIPANIAANEALKVRLLETEGVKEVLIAEEEHSAYVKIDSKVTNRFEVEQAIRQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JN6</accession>
    <name>GMHA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoheptose isomerase</fullName>
            <ecNumber evidence="1">5.3.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sedoheptulose 7-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gmhA</name>
        <name type="ordered locus">SDY_0248</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27489"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:60203"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="EC" id="5.3.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. GmhA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.28" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378551.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401960.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JN6"/>
    <dbReference type="SMR" id="Q32JN6"/>
    <dbReference type="STRING" id="300267.SDY_0248"/>
    <dbReference type="EnsemblBacteria" id="ABB60471">
        <property type="protein sequence ID" value="ABB60471"/>
        <property type="gene ID" value="SDY_0248"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0248"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.279"/>
    <dbReference type="HOGENOM" id="CLU_080999_4_0_6"/>
    <dbReference type="OMA" id="FLAHKEA"/>
    <dbReference type="UniPathway" id="UPA00041">
        <property type="reaction ID" value="UER00436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008968">
        <property type="term" value="F:D-sedoheptulose 7-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001061">
        <property type="term" value="P:D-glycero-D-manno-heptose 7-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00067">
        <property type="entry name" value="GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004515">
        <property type="entry name" value="Phosphoheptose_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00441">
        <property type="entry name" value="gmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000009097" description="Phosphoheptose isomerase">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="37"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00067"/>
        </source>
    </evidence>
    <sequence length="192" mass="20820" checksum="041319911BFD7A55" modified="2005-12-06" version="1">MYQDLIRNELNEAAETLANFLKDDANIHAIQRAAVLLADSFKAGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHISCVGNDFGFNDIFSRYVEAVGCEGDVLLGISTSGNSANVIKAIAAAREKGMKVITLTGKDGGKMADTADIEIRVPHFGYADRIQEIHIKVIHILIQLIEKEMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JN9</accession>
    <name>Q32JN9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_0244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JN9"/>
    <dbReference type="EnsemblBacteria" id="ABB60468">
        <property type="protein sequence ID" value="ABB60468"/>
        <property type="gene ID" value="SDY_0244"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0244"/>
    <dbReference type="HOGENOM" id="CLU_036805_13_1_6"/>
    <dbReference type="OMA" id="NRRNGCY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="220" mass="25244" checksum="EFF4850B896CF098" modified="2005-12-06" version="1">MFLALGINTDGQKELLGMWLAENEGAKFWLGVLTELKNRGLQDILIACVDGLKGFPEAINSVYPQTHIQLCIIHMVRNSLKFVSWKDYKAVTSGLKAVYQAPTEEAALMTLDKFAGVWDEKYPQISKSWRTHWENLNTFFGYPPDIRKAIYTTNAIESLNSVIRQAIKKRKVFPTDDSVRKVIYLAIQSASKKWSMPIQNWRLAMSRFIIEFGDRLSEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JU5</accession>
    <name>Q32JU5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JU5"/>
    <dbReference type="STRING" id="300267.SDY_0180"/>
    <dbReference type="EnsemblBacteria" id="ABB60412">
        <property type="protein sequence ID" value="ABB60412"/>
        <property type="gene ID" value="SDY_0180"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0180"/>
    <dbReference type="HOGENOM" id="CLU_2195048_0_0_6"/>
    <dbReference type="OMA" id="AQMITRH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="46"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="108" mass="12666" checksum="77CBF0447BD26CD3" modified="2005-12-06" version="1">MPESRCYFYQDLMLPVLLDSLRGDWQANELARSLARLKAMDNNGLLRRTLAAWFRHNVQPLATSKALFIHRNTLEYRLNRISELTGLDLGNFDDRLLLYVALQLDEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JY2</accession>
    <name>Q32JY2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulates ampC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ampE</name>
        <name evidence="2" type="ordered locus">SDY_0141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000171997.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401864.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JY2"/>
    <dbReference type="STRING" id="300267.SDY_0141"/>
    <dbReference type="EnsemblBacteria" id="ABB60375">
        <property type="protein sequence ID" value="ABB60375"/>
        <property type="gene ID" value="SDY_0141"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0141"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.159"/>
    <dbReference type="HOGENOM" id="CLU_054212_2_2_6"/>
    <dbReference type="OMA" id="GPFRDAW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031347">
        <property type="entry name" value="AmpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17113">
        <property type="entry name" value="AmpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="284" mass="32069" checksum="D236BF097F41D7AD" modified="2005-12-06" version="1">MTLFTTLLVLIFERLFKLGEHWQLDHRLEAFFRRVKHFSLGRTLGMTIIAMGVTFLLLRALQGVLFNVPTLLVWLLIGLLCIGAGKVRLHYHAYLTAASRNDSHARATMAGELTMIHGVPAGCDEREYLCELQNALLWINFRFYLAPLFWLIVGGTWGPVTLMGYAFLRAWQYWLARYQTPHHRLQSGIDAVLHVLDWVPVRLAGVVYALIGHGEKALPAWFASLGDFHTSQYQVLTRLAQFSLAREPHVDKVETPKAAVSMAKKTSFVVVVVIALLTIYGALV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K04</accession>
    <name>MURD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="1">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murD</name>
        <name type="ordered locus">SDY_0118</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000796482.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401842.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K04"/>
    <dbReference type="SMR" id="Q32K04"/>
    <dbReference type="STRING" id="300267.SDY_0118"/>
    <dbReference type="PRIDE" id="Q32K04"/>
    <dbReference type="EnsemblBacteria" id="ABB60353">
        <property type="protein sequence ID" value="ABB60353"/>
        <property type="gene ID" value="SDY_0118"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0118"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.137"/>
    <dbReference type="HOGENOM" id="CLU_032540_1_0_6"/>
    <dbReference type="OMA" id="CNFENYL"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000257237" description="UDP-N-acetylmuramoylalanine--D-glutamate ligase">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <sequence length="438" mass="47002" checksum="0ED6589C06438B16" modified="2005-12-06" version="1">MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGVQLAALRPEVAEKTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K12</accession>
    <name>Q32K12_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Catabolite repressor/activator</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fructose repressor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fruR</name>
        <name evidence="7" type="ordered locus">SDY_0110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000762408.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401834.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K12"/>
    <dbReference type="STRING" id="300267.SDY_0110"/>
    <dbReference type="EnsemblBacteria" id="ABB60345">
        <property type="protein sequence ID" value="ABB60345"/>
        <property type="gene ID" value="SDY_0110"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0110"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.129"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_6"/>
    <dbReference type="OMA" id="NSRKAGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009750">
        <property type="term" value="P:response to fructose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012781">
        <property type="entry name" value="Fruct_sucro_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02417">
        <property type="entry name" value="fruct_sucro_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="334" mass="38025" checksum="50315924CC2EC0D9" modified="2005-12-06" version="1">MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDAIIVSTSLPPEHPFYQRWANDPFPIVALDRALDREHFTSVVGADQDDAEMLAEELRKFPAETVLYLGALPELSVSFLREQGFRTAWKDDPREVYFLYANSYEREAAAQLFEKWLETHPMPQALFTTSFALLQGVMDVTLRRDGKLPSDLAIATFGDNELLDFLQCPVLAVAQRHRDVAERVLEIVLASLDEPRKPKPGLTRIKRNLYRRGVLSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K69</accession>
    <name>Q32K69_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">slpA</name>
        <name evidence="6" type="ordered locus">SDY_0050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000004660.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401777.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K69"/>
    <dbReference type="STRING" id="300267.SDY_0050"/>
    <dbReference type="EnsemblBacteria" id="ABB60288">
        <property type="protein sequence ID" value="ABB60288"/>
        <property type="gene ID" value="SDY_0050"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0050"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.54"/>
    <dbReference type="HOGENOM" id="CLU_098197_3_0_6"/>
    <dbReference type="OMA" id="FGQTEDH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="149" mass="16115" checksum="48634C44E1980A10" modified="2005-12-06" version="1">MSESVQSNSAVLVHFTLKLDDGTTAESTRNNGKPALFRLGDASLSEGLEQHLLGLKVGDKTTFSLEPDAAFGVSSPDLIQYFSRREFMDAGEPEIGAIMLFTVMDGSEMLGVIREINGDSITVDFNHPLAGQTVHFDIEVLEIDPALEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KA0</accession>
    <name>NHAA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nhaA</name>
        <name type="ordered locus">SDY_0018</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29252"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000681370.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401746.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KA0"/>
    <dbReference type="SMR" id="Q32KA0"/>
    <dbReference type="STRING" id="300267.SDY_0018"/>
    <dbReference type="EnsemblBacteria" id="ABB60258">
        <property type="protein sequence ID" value="ABB60258"/>
        <property type="gene ID" value="SDY_0018"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0018"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.19"/>
    <dbReference type="HOGENOM" id="CLU_015803_1_0_6"/>
    <dbReference type="OMA" id="MGLMLRC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0915">Sodium</keyword>
    <keyword id="KW-0739">Sodium transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000334436" description="Na(+)/H(+) antiporter NhaA">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="117"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="1">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="177"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="201"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=7" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=8" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=9" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=10" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=11" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="351"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=12" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <sequence length="388" mass="41378" checksum="127D8848B4E6EA91" modified="2005-12-06" version="1">MKHLHRFFSSDASGGIILIIAAILAMMMANSGATSGWYHDFLETPVQLRVGSLEINKNMLLWINDALMAVFFLLVGLEVKRELMQGSLASLRQAAFPVIAAIGGMIVPALLYLAFNYADPITREGWAIPAATDIAFALGVLALLGSRVPLALKIFLMALAIIDDLGAIIIIALFYTNDLSMASLGVAAVAIAVLAVLNLCGVRRTGVYILVGVVLWTAVLKSGVHATLAGVIVGFFIPLKEKHGRSTAKRLEHVLHPWVAYLILPLFAFANAGVSLQGVTLDGLTSILPLGIIAGLLIGKPLGISLFCWLALRLKLAHLPEGTTYQQIMAVGILCGIGFTMSIFIASLAFGSVDPELINWAKLGILVGSISSAVIGYSWLRVRLRPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q326N6</accession>
    <name>Q326N6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS629 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406210.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326N6"/>
    <dbReference type="EnsemblBacteria" id="ABB64723">
        <property type="protein sequence ID" value="ABB64723"/>
        <property type="gene ID" value="SDY_P210"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P210"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5763"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_8_6"/>
    <dbReference type="OMA" id="KRSACAQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="118" mass="13711" checksum="69FD680C537427F7" modified="2005-12-06" version="1">MMPLLDKLREQYGVGPLCSELHIAPSTYYYCQQQRHHPDKRSARAQRDDWLKKEIQRVYDENHKVYGVKSGVSCYGKVSEWPDALWHVSWRLWDLPVFSGVKRSVRPSAGKPLPQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q326T9</accession>
    <name>Q326T9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406157.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326T9"/>
    <dbReference type="EnsemblBacteria" id="ABB64669">
        <property type="protein sequence ID" value="ABB64669"/>
        <property type="gene ID" value="SDY_P156"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P156"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5713"/>
    <dbReference type="HOGENOM" id="CLU_745758_0_0_6"/>
    <dbReference type="OMA" id="GACCTES"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014737">
        <property type="entry name" value="Transposase_Tn5-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="371" mass="41653" checksum="D1AE6D0A8605A2B4" modified="2005-12-06" version="1">MADVADRRELRQFRQTPEQRFTQEQEHLQPLLGTDFDIRHVSWDGYIEVGGNRYSVPESLCGQLVSIRISLDDELRIYSNEQQVASHRLCSAAYGWQTVPEHHAPLWQQASERMAERLGEIQKRVITVCDREADIWHYLYYKVSHGQRGACCTESPAGRGTRQALRTAGSPGNRRKPHAECDAKRRAGSPSGPDVHQLQRSQHKKSRQQRPGAPAHVCLLPGAGRGRCLLASADVRKSGECRRCTTYCQPLRATLADRGIPQGVEKWWYMESLRMQTRDNLERMVVIKAFIAVRVLGLRQGGVSEETQNDSCEKILTPTEWKLLWVKLEGKPLPVQAPTLKWAWGDGMTANAQVVPVGSSCGMAGQTSGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q326V4</accession>
    <name>Q326V4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Invasion plasmid antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ipaH</name>
        <name evidence="3" type="ordered locus">SDY_P140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011379009.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406142.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326V4"/>
    <dbReference type="EnsemblBacteria" id="ABB64653">
        <property type="protein sequence ID" value="ABB64653"/>
        <property type="gene ID" value="SDY_P140"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P140"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5698"/>
    <dbReference type="HOGENOM" id="CLU_529858_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029487">
        <property type="entry name" value="NEL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14496">
        <property type="entry name" value="NEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="343"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="514" mass="58169" checksum="C61BF1E76B6BA7CF" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q326W3</accession>
    <name>Q326W3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406133.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326W3"/>
    <dbReference type="EnsemblBacteria" id="ABB64645">
        <property type="protein sequence ID" value="ABB64645"/>
        <property type="gene ID" value="SDY_P132"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P132"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5687"/>
    <dbReference type="HOGENOM" id="CLU_220302_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="37" mass="4096" checksum="802C47CDDB3FEB69" modified="2005-12-06" version="1">MKLIIFILIVLIIAALLIRIILRSVNQHSPLLGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q326X6</accession>
    <name>Q326X6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrbH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trbH</name>
        <name evidence="2" type="ordered locus">SDY_P119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406120.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326X6"/>
    <dbReference type="EnsemblBacteria" id="ABB64632">
        <property type="protein sequence ID" value="ABB64632"/>
        <property type="gene ID" value="SDY_P119"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P119"/>
    <dbReference type="HOGENOM" id="CLU_1160454_0_0_6"/>
    <dbReference type="OMA" id="CLLMWIC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="239" mass="26209" checksum="66E91C12D9AC12E0" modified="2005-12-06" version="1">MNRSAPVFNSQAAHTFKFPGVVSHNNQPPTAGMTCDHLIKWPDRASLTGKFCSYLAGVYGCSGVVIQNINAGNKSLDHSEITFRHLAFFCTIYQLHQGDRTDTHSPLVKVKTLPDAGGFVLYRKNTDVGIEHKLQHQNDSLSCMSGCSLLSIKSALTLCPSNHSSHVSPAGVMIRVRPTAITSTRFTFSGNATAFGSLTAWLRLLRNTVVSIICLLMWICLVYIHCGIDTGICQRDIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q327D4</accession>
    <name>Q327D4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406062.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327D4"/>
    <dbReference type="EnsemblBacteria" id="ABB64574">
        <property type="protein sequence ID" value="ABB64574"/>
        <property type="gene ID" value="SDY_P061"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P061"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5607"/>
    <dbReference type="HOGENOM" id="CLU_183819_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="96" mass="10133" checksum="CF1AB6CB86FEF663" modified="2005-12-06" version="1">MSLALTAGLSIVKSSQSTAQVEGACRLMRNPSVSPQAIAEAGFTATARACEAHPLLLALEDTTTINFSHSTAFDDLGNTTGDADDFLDSQEMKHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q327D5</accession>
    <name>Q327D5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_P060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Sd197</strain>
            <plasmid evidence="8">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406061.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327D5"/>
    <dbReference type="EnsemblBacteria" id="ABB64573">
        <property type="protein sequence ID" value="ABB64573"/>
        <property type="gene ID" value="SDY_P060"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P060"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5606"/>
    <dbReference type="HOGENOM" id="CLU_036805_10_3_6"/>
    <dbReference type="OMA" id="SIVWINA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="192" mass="21848" checksum="9C7978405447F7FE" modified="2005-12-06" version="1">MELRTPRDRDGSFEPQLVKKNQTRITGMDNQLLALYARGMTTREITSVFKEMYDADVSPALISKVTDAVIDQVVEWQNRPLDAIYPIVYLDCIVLKVRQDSRVINKAVFLALGINLDGQKELLGMWLAENEGAKFWLNVLTELKNRGLNDILIACVDGLKGYFLIVIHELTSSLDMPVSVIRVVHDALCRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q327D6</accession>
    <name>Q327D6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406060.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327D6"/>
    <dbReference type="EnsemblBacteria" id="ABB64572">
        <property type="protein sequence ID" value="ABB64572"/>
        <property type="gene ID" value="SDY_P059"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P059"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5605"/>
    <dbReference type="HOGENOM" id="CLU_036805_12_10_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="42" mass="4813" checksum="72587FF378CD00BE" modified="2005-12-06" version="1">MDDKQLQALANELAKNLKTPEDLSQFDRLLKKSVLRLLSTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q327F8</accession>
    <name>Q327F8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ipaH4.5</name>
        <name evidence="13" type="ordered locus">SDY_P037</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="13 14">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Sd197</strain>
            <plasmid evidence="14">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LRR-containing bacterial E3 ligase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011379044.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406038.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327F8"/>
    <dbReference type="EnsemblBacteria" id="ABB64550">
        <property type="protein sequence ID" value="ABB64550"/>
        <property type="gene ID" value="SDY_P037"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P037"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5579"/>
    <dbReference type="HOGENOM" id="CLU_018533_2_0_6"/>
    <dbReference type="OMA" id="IKGETME"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032674">
        <property type="entry name" value="LRR_E3_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029487">
        <property type="entry name" value="NEL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14496">
        <property type="entry name" value="NEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12468">
        <property type="entry name" value="TTSSLRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0614">Plasmid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="TTSSLRR" evidence="11">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="NEL" evidence="12">
        <location>
            <begin position="303"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB64550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="574" mass="65463" checksum="5854FC0201C2D9DD" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q327M2</accession>
    <name>RF3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide chain release factor 3</fullName>
            <shortName evidence="1">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prfC</name>
        <name type="ordered locus">SDY_4634</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000175940.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405974.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327M2"/>
    <dbReference type="SMR" id="Q327M2"/>
    <dbReference type="STRING" id="300267.SDY_4634"/>
    <dbReference type="EnsemblBacteria" id="ABB64483">
        <property type="protein sequence ID" value="ABB64483"/>
        <property type="gene ID" value="SDY_4634"/>
    </dbReference>
    <dbReference type="GeneID" id="60903174"/>
    <dbReference type="KEGG" id="sdy:SDY_4634"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5492"/>
    <dbReference type="HOGENOM" id="CLU_002794_2_1_6"/>
    <dbReference type="OMA" id="GFVFKIH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000242208" description="Peptide chain release factor 3">
        <location>
            <begin position="1"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="11"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <sequence length="529" mass="59574" checksum="2A1E6AE984C6B1C6" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q327X2</accession>
    <name>Q327X2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="6" type="ordered locus">SDY_4508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000168299.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405874.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327X2"/>
    <dbReference type="STRING" id="300267.SDY_4508"/>
    <dbReference type="EnsemblBacteria" id="ABB64383">
        <property type="protein sequence ID" value="ABB64383"/>
        <property type="gene ID" value="SDY_4508"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4508"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5329"/>
    <dbReference type="HOGENOM" id="CLU_078758_0_2_6"/>
    <dbReference type="OMA" id="GQMQERT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="DNA-binding region" evidence="2">
        <location>
            <begin position="55"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Important for interaction with partner proteins" evidence="2">
        <location>
            <begin position="173"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="178" mass="18991" checksum="A0BA03B6DC8D1827" modified="2005-12-06" version="1">MASRGVNKVILVGNLGQDPEVRYMPNGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGKLAEVASEYLRKGSQVYIEGQLRTRKWTDQSGQDRYTTEVVVNVGGTMQMLGGRQGGGAPAGGNIGGGQLQGGWGQPQQPQGGNQFSGGAQSRPQQSAPAAPSNEPPMDFDDDIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Y9</accession>
    <name>Q327Y9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405857.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Y9"/>
    <dbReference type="STRING" id="300267.SDY_4490"/>
    <dbReference type="EnsemblBacteria" id="ABB64366">
        <property type="protein sequence ID" value="ABB64366"/>
        <property type="gene ID" value="SDY_4490"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4490"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5303"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="258" mass="29824" checksum="39B840498856A0E5" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSVSSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q328C1</accession>
    <name>Q328C1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytfJ</name>
        <name evidence="2" type="ordered locus">SDY_4453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000175272.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405825.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328C1"/>
    <dbReference type="STRING" id="300267.SDY_4453"/>
    <dbReference type="EnsemblBacteria" id="ABB64334">
        <property type="protein sequence ID" value="ABB64334"/>
        <property type="gene ID" value="SDY_4453"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4453"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5253"/>
    <dbReference type="HOGENOM" id="CLU_091011_0_0_6"/>
    <dbReference type="OMA" id="QFSYKNW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006513">
        <property type="entry name" value="CHP01626_YtfJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09695">
        <property type="entry name" value="YtfJ_HI0045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01626">
        <property type="entry name" value="ytfJ_HI0045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220567" evidence="1">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="184" mass="20436" checksum="DF743AA439BAEC6B" modified="2005-12-06" version="1">MTLRKILALTCLLLPMMASAHQFETGQRVPPIGITDRGELVLDKDQFSYKTWNSAQLVGKVQVLQHIAGRTSAKEKNATLIEAIKSAKLPHDRYQTTTIVNTDDAIPGSGMFVRSSLESNKKLYPWSQFIVDSNGVARGAWQLDEESSAVVVLDKDGRVQWAKDGALTPEEVQQVMDLLQKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q328G3</accession>
    <name>Q328G3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328G3"/>
    <dbReference type="EnsemblBacteria" id="ABB64292">
        <property type="protein sequence ID" value="ABB64292"/>
        <property type="gene ID" value="SDY_4405"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4405"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="9690" checksum="DC93A4A5CE3014AD" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITNFHIFHLANRNQRRICRIRLQAHSPCRPQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q328K5</accession>
    <name>ULAG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable L-ascorbate-6-phosphate lactonase UlaG</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-ascorbate utilization protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ulaG</name>
        <name type="ordered locus">SDY_4361</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-ascorbate 6-phosphate = 3-dehydro-L-gulonate 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28803"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58774"/>
            <dbReference type="ChEBI" id="CHEBI:61698"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor degradation; L-ascorbate degradation; D-xylulose 5-phosphate from L-ascorbate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">Induced by L-ascorbate. Repressed by UlaR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UlaG family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous termination">
            <sequence resource="EMBL-CDS" id="ABB64250" version="1"/>
        </conflict>
        <text>Truncated C-terminus.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64250.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328K5"/>
    <dbReference type="SMR" id="Q328K5"/>
    <dbReference type="STRING" id="300267.SDY_4361"/>
    <dbReference type="EnsemblBacteria" id="ABB64250">
        <property type="protein sequence ID" value="ABB64250"/>
        <property type="gene ID" value="SDY_4361"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4361"/>
    <dbReference type="HOGENOM" id="CLU_074775_0_0_6"/>
    <dbReference type="UniPathway" id="UPA00263">
        <property type="reaction ID" value="UER00377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035460">
        <property type="term" value="F:L-ascorbate 6-phosphate lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019854">
        <property type="term" value="P:L-ascorbic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01266">
        <property type="entry name" value="UlaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023951">
        <property type="entry name" value="L-ascorbate_6P_UlaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000231490" description="Probable L-ascorbate-6-phosphate lactonase UlaG">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="354" mass="40159" checksum="C1BDE171CC4182CA" modified="2006-04-04" version="2">MSKVKSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWLKSEGGTNVCVDFWCDTGKQSHGNPLMKQGHQMQRMAGVKKLQPNLRTNPFVLDPFAIRQIDAVLANHDHNDHIDVNVAAAVMQNCADDVPFIGPKTCVDLWIGWGVPKERCIVVKPGDVVKVKDIEIHALDAFDRTALITLPADQKAAGILPDGMDDRAVNYLFKTPGGSLYHSGDSHYSNYYAKHGNEHQIDVALGSYGENPRGITDKMTSADMLRMGEALNAKVVIPFHHDIWSNFQADPQEIRVLWEMKKDRLKYGFKPFIWQVGGKFTWPLDKDNFEYHYPRGFDDCFTIEPDLPFKSFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q328K6</accession>
    <name>ULAR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional regulator UlaR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ulaR</name>
        <name type="ordered locus">SDY_4360</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Represses ulaG and the ulaABCDEF operon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000133627.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405740.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328K6"/>
    <dbReference type="SMR" id="Q328K6"/>
    <dbReference type="STRING" id="300267.SDY_4360"/>
    <dbReference type="EnsemblBacteria" id="ABB64249">
        <property type="protein sequence ID" value="ABB64249"/>
        <property type="gene ID" value="SDY_4360"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4360"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5148"/>
    <dbReference type="HOGENOM" id="CLU_060699_3_2_6"/>
    <dbReference type="OMA" id="RYDFFNF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01563">
        <property type="entry name" value="HTH_type_UlaR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023711">
        <property type="entry name" value="Tscrpt_reg_HTH_UlaR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000234027" description="HTH-type transcriptional regulator UlaR">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="HTH deoR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01563"/>
        </source>
    </evidence>
    <sequence length="251" mass="27592" checksum="B4F94CE01BAFB97D" modified="2005-12-06" version="1">MTEAQRHQILLEMLAQLGFVTVEKVVERLGISPATARRDINKLDESGKLKKVRNGAEAITQQRPRWTPMNLHQAQNHDEKVRIAKAASQLVNPGESVVINCGSTAFLLGQEMCGKPVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQSITLSPQGSENSLYAGHWMFTSSKGLTAEGLYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNANPETLQQLEAQGVSILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Z3</accession>
    <name>Q328Z3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Z3"/>
    <dbReference type="EnsemblBacteria" id="ABB64112">
        <property type="protein sequence ID" value="ABB64112"/>
        <property type="gene ID" value="SDY_4208"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4208"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="10018" checksum="5D93E59BF0966D36" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITNNLKLLLLINRLMSDVLRHLLFLLSMIKKQFHY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q329F4</accession>
    <name>NEPI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Purine ribonucleoside efflux pump NepI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nepI</name>
        <name type="ordered locus">SDY_4141</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the efflux of purine ribonucleosides, such as inosine and guanosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(out) + inosine(in) = H(+)(in) + inosine(out)</text>
            <dbReference type="Rhea" id="RHEA:29211"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29212"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(in) + H(+)(out) = guanosine(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29583"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29584"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB64051" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64051.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001288543.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405542.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329F4"/>
    <dbReference type="SMR" id="Q329F4"/>
    <dbReference type="STRING" id="300267.SDY_4141"/>
    <dbReference type="EnsemblBacteria" id="ABB64051">
        <property type="protein sequence ID" value="ABB64051"/>
        <property type="gene ID" value="SDY_4141"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4141"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4868"/>
    <dbReference type="HOGENOM" id="CLU_001265_61_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015211">
        <property type="term" value="F:purine nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01189">
        <property type="entry name" value="MFS_NepI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023680">
        <property type="entry name" value="MFS_NepI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000294118" description="Purine ribonucleoside efflux pump NepI">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="169"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="277"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="365"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="388"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="394" mass="41517" checksum="17793F7B775AD2EF" modified="2007-07-10" version="2">MSEFIAENRGADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTISCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGVLCIFWIIKSLPSLPGKPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSFGIASFIGTSLSSFILKRSVKLALAGAPLILAVSALVLTLCGSDKIVATGVAIIWGLTFALVPVGWSTWSTRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q329G3</accession>
    <name>Q329G3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_4132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001128440.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405533.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329G3"/>
    <dbReference type="STRING" id="300267.SDY_4132"/>
    <dbReference type="EnsemblBacteria" id="ABB64042">
        <property type="protein sequence ID" value="ABB64042"/>
        <property type="gene ID" value="SDY_4132"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4132"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4857"/>
    <dbReference type="HOGENOM" id="CLU_040088_0_1_6"/>
    <dbReference type="OMA" id="MEICGSA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="231"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="286" mass="31050" checksum="981E9E362F94198A" modified="2005-12-06" version="1">MPLISLAEGLAHAREHHYSLGAFNVLDSHFLRALFAAARQERSPFIINIAEVHFKYISLDSLVETVKFEAARHAIPVVLNLDHGLHFESVVQALRLGFSSVMFDGSTLGYEENVRQTREVVKMCHAVGVSVEAELGAVGGDKGGALYGHADESLFTDPQLARDFVDRTGIDALAVAIGNAHGKYRGEPKLDFPRLDAICQQAAIPLVLHGGSGISDADFRRVIELGIHKINFYTGMSQAALAAVEARMAHRQPMYDEFAELLLAVEAAISDTVAQQMRIFGSAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q329N7</accession>
    <name>Q329N7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <shortName evidence="1">AKB ligase</shortName>
            <ecNumber evidence="1">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">kbl</name>
        <name evidence="3" type="ordered locus">SDY_4050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="1">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001213843.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405459.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329N7"/>
    <dbReference type="STRING" id="300267.SDY_4050"/>
    <dbReference type="EnsemblBacteria" id="ABB63968">
        <property type="protein sequence ID" value="ABB63968"/>
        <property type="gene ID" value="SDY_4050"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4050"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4766"/>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_6"/>
    <dbReference type="OMA" id="MDTHGFG"/>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="210"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="241"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding; shared with dimeric partner" evidence="1">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="398" mass="43145" checksum="7E6AA7A3AA25B8A5" modified="2005-12-06" version="1">MRGEFYQQLTNDLETARAEGLFKEERIITSAQQADITVADGSHVINFCANNYLGLANHPDLIAAAKAGMDSHGFGMASVRFICGTQDSHKELEQKLAAFLGMEDAILYSSCFDANGGLFETLLGAEDAIISDVLNHASIIDGVRLCKAKRYRYANNDMQELEARLKEAREAGARHVLIATDGVFSMDGVIANLKGVCDLADKYDALVMVDDSHAVGFVGENGRGSHEYCDVMGRVDIITGTLGKALGGASGGYTAARKEVVEWLRQRSRPYLFSNSLAPAIVAASIKVLEMVEAGSELRDRLWANARQFREQMSAAGFTLAGADHAIIPVMLGDAVVAQKFARELQKEGIYVTGFFYPVVPKGQARIRTQMSAAHTPEQITRAVEAFTRIGKQLGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Q9</accession>
    <name>Q329Q9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405437.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Q9"/>
    <dbReference type="EnsemblBacteria" id="ABB63946">
        <property type="protein sequence ID" value="ABB63946"/>
        <property type="gene ID" value="SDY_4028"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4028"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4742"/>
    <dbReference type="HOGENOM" id="CLU_107957_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="167" mass="19736" checksum="356EDBF7377369F7" modified="2005-12-06" version="1">MEKQKLFSTVKNFKAEEKIKQEKYIEKPADVAREIASFFDVEKYLLGGIDRSNNYINENFTYKLLDLANLSGARDAQLERKVYFNEKMIKLNDNDEKEKVKIENDIKKIDKKIEEIDNAIWDLSSETERFKIKFQQENTLNDVVQSISSWLKENQNMVKAIKKIDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q329S8</accession>
    <name>Q329S8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane-bound ATP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpI</name>
        <name evidence="7" type="ordered locus">SDY_4009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329S8"/>
    <dbReference type="STRING" id="300267.SDY_4009"/>
    <dbReference type="EnsemblBacteria" id="ABB63927">
        <property type="protein sequence ID" value="ABB63927"/>
        <property type="gene ID" value="SDY_4009"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4009"/>
    <dbReference type="HOGENOM" id="CLU_121415_2_0_6"/>
    <dbReference type="OMA" id="YMYMQVE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005598">
        <property type="entry name" value="ATP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03899">
        <property type="entry name" value="ATP-synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="130" mass="14104" checksum="D6854BF7E29DA21A" modified="2005-12-06" version="1">MKNVMSVSLVSRNVARKLLLVQLLVVIASGLLFSLKDPFWGVSAISGGLAVFLPNVLFMIFAWRHQAHTPAKGRVAWTFAFGEAFKVLAMLVLLVVALAVLKAVFLPLIVTWVLVLVVQILAPAVINNKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q329U3</accession>
    <name>HDFR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional regulator HdfR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">H-NS-dependent flhDC regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hdfR</name>
        <name type="ordered locus">SDY_3985</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000379246.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405403.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329U3"/>
    <dbReference type="SMR" id="Q329U3"/>
    <dbReference type="STRING" id="300267.SDY_3985"/>
    <dbReference type="EnsemblBacteria" id="ABB63912">
        <property type="protein sequence ID" value="ABB63912"/>
        <property type="gene ID" value="SDY_3985"/>
    </dbReference>
    <dbReference type="GeneID" id="66672334"/>
    <dbReference type="KEGG" id="sdy:SDY_3985"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4699"/>
    <dbReference type="HOGENOM" id="CLU_039613_8_2_6"/>
    <dbReference type="OMA" id="ESLMNTW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01233">
        <property type="entry name" value="HTH_type_HdfR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020890">
        <property type="entry name" value="Tscrpt_reg_HTH_HdfR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000066898" description="HTH-type transcriptional regulator HdfR">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="279" mass="31776" checksum="44BFF5A542BDE913" modified="2005-12-06" version="1">MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGEKLLPYAETLMSTWQAARKEVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDAHTGLQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLGYFTLALYTSAPSKLKGDLNYLRLEWGPDFQQHEAGLIGADEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLHTVVDSTTLSRPLYAIWLQNSDKNTLIRDLLKINVLDEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Z1</accession>
    <name>Q329Z1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yigE</name>
        <name evidence="3" type="ordered locus">SDY_3930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000951163.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405355.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Z1"/>
    <dbReference type="STRING" id="300267.SDY_3930"/>
    <dbReference type="EnsemblBacteria" id="ABB63864">
        <property type="protein sequence ID" value="ABB63864"/>
        <property type="gene ID" value="SDY_3930"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3930"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4641"/>
    <dbReference type="HOGENOM" id="CLU_076045_1_0_6"/>
    <dbReference type="OMA" id="QSGPMLI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220700" evidence="1">
        <location>
            <begin position="33"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="2">
        <location>
            <begin position="84"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="254" mass="28025" checksum="E03B3304AAC0BF6A" modified="2005-12-06" version="1">MAHRLLIGKGMITLNLKRIFLALTLLPLFAVAADDCALSDPTLTVQAYTVNPQTERVKMYWQKANGEAWGTLHALLADMNSQGQVQMAMNGGIYDESYAPLGLYIENGQQKVALNLASGEGNFFIRPGGVFYVAGDKVGIVRLDAFKTSKEIQFAVQSGPMLMENSVINPRIHPNVASRKIRNGVGINKHGNAVFLLSQQATNFYDFACYAKAKLNVEQLLYLDGTISHMYMKGGAIPWQRYPFVTMISVEQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A38</accession>
    <name>Q32A38_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coproporphyrinogen-III oxidase</fullName>
            <ecNumber evidence="12">1.3.98.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">hemN</name>
        <name evidence="16" type="ordered locus">SDY_3876</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>coproporphyrinogen III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX</text>
            <dbReference type="Rhea" id="RHEA:15425"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="1.3.98.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the anaerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.3" evidence="12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A38"/>
    <dbReference type="STRING" id="300267.SDY_3876"/>
    <dbReference type="EnsemblBacteria" id="ABB63817">
        <property type="protein sequence ID" value="ABB63817"/>
        <property type="gene ID" value="SDY_3876"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3876"/>
    <dbReference type="HOGENOM" id="CLU_027579_3_0_6"/>
    <dbReference type="OMA" id="LMCNLEL"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051989">
        <property type="term" value="F:coproporphyrinogen dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004558">
        <property type="entry name" value="Coprogen_oxidase_HemN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000167">
        <property type="entry name" value="HemN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00277">
        <property type="entry name" value="oxygen-independent_coproporphy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00538">
        <property type="entry name" value="hemN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="49"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000167-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000167-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB63817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="459" mass="52913" checksum="7817E107161B2CA1" modified="2005-12-06" version="1">MSMSVQQIDWDLALIQKYNYSGPRYTSYPTALEFSEDFGEQAFLQAVARYPERPLSLYVHIPFCHKLCYFCGCNKIVTRQQHKADQYLDALEQEIVHRAPLFAGRHVSQLHWGGGTPTYLNKAQISRLMKLLRENFQFNADAEISIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQRLVNREQDEEFIFALLNHAREIGLTSTNIDLIYGLPKQTPESFAFTLKRVAELNPDRLSVFNYAHLPTIFAAQRKIKDADLPSPQQKLDILQETIAFLTQSGYQFIGMDHFARPDDELAVAQREGVLHRNFQGYTTQGDTDLLGMGVSAISMIGDCYAQNQKELKQYYQQVDEQGNALWRGIALTRDDCIRRDVIKSLICNFRLDYAPIEKQWDLHFADYFAEDLKLLAPLAKDGLVDVDEKGIQVTAKGRLLIRNICMCFDTYLRQKARMQQFSRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A95</accession>
    <name>Q32A95_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405251.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A95"/>
    <dbReference type="EnsemblBacteria" id="ABB63760">
        <property type="protein sequence ID" value="ABB63760"/>
        <property type="gene ID" value="SDY_3815"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3815"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4506"/>
    <dbReference type="HOGENOM" id="CLU_2332107_0_0_6"/>
    <dbReference type="OMA" id="IFQFHDC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="98" mass="11524" checksum="B0961A0DC82E76C3" modified="2005-12-06" version="1">MPVHLNSLEELKKMQRDNLKDQYNEEIFQFHDCNAKHFTCKYQDVLINFDGQQKRTISVYLEDTPRAVGIIALMEPDTADKYRQQAMEIMLSAKNTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AF1</accession>
    <name>Q32AF1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AF1"/>
    <dbReference type="EnsemblBacteria" id="ABB63704">
        <property type="protein sequence ID" value="ABB63704"/>
        <property type="gene ID" value="SDY_3753"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3753"/>
    <dbReference type="HOGENOM" id="CLU_3199120_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="51" mass="5738" checksum="C71484AA76C7262F" modified="2005-12-06" version="1">METCEFMQLKNCIICFIGHILCDTMKKQPNGGQISTLFQHHCAQQCAPAKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AG9</accession>
    <name>NUDC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-capped RNA hydrolase NudC</fullName>
            <shortName evidence="1">DeNADding enzyme NudC</shortName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH pyrophosphatase</fullName>
            <ecNumber evidence="1">3.6.1.22</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nudC</name>
        <name type="ordered locus">SDY_3730</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11800"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide</text>
            <dbReference type="Rhea" id="RHEA:48868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90832"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Divalent metal cations. Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EC" id="3.6.1.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000373928.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405177.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AG9"/>
    <dbReference type="SMR" id="Q32AG9"/>
    <dbReference type="STRING" id="300267.SDY_3730"/>
    <dbReference type="EnsemblBacteria" id="ABB63686">
        <property type="protein sequence ID" value="ABB63686"/>
        <property type="gene ID" value="SDY_3730"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3730"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4422"/>
    <dbReference type="HOGENOM" id="CLU_037162_0_1_6"/>
    <dbReference type="OMA" id="TWAREHR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110153">
        <property type="term" value="F:RNA NAD-cap (NMN-forming) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00297">
        <property type="entry name" value="Nudix_NudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022925">
        <property type="entry name" value="RNA_Hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000232123" description="NAD-capped RNA hydrolase NudC">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="125"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nudix box" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00297"/>
        </source>
    </evidence>
    <sequence length="257" mass="29657" checksum="098154C3AB9CEC1F" modified="2005-12-06" version="1">MDRIIEKLDHGWWVVSHEQKLWLPKGELPYGEAANFDLVGQRALQIGEWQGEPVWLIQQQRRHDMGSVRQVIDLDVGLFLLAGRGVQLAEFYRSHKYCGYCGHEMYPSKTEWAMLCSHCRERYYPQIAPCIIVAIRRDDSILLAQHTRHRNGVHTVLAGFVEVGETLEQAVAREVMEESGIKVKNLRYVTSQPWPFPQSLMTAFMADYDSGDIVIDPKELLEANWYRYDNLPLLPVPGTVARRLIEDTVALCRAEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AI7</accession>
    <name>Q32AI7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanine-alpha-ketoisovalerate (Or valine-pyruvate) transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">avtA</name>
        <name evidence="2" type="ordered locus">SDY_3707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000144370.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405159.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AI7"/>
    <dbReference type="STRING" id="300267.SDY_3707"/>
    <dbReference type="EnsemblBacteria" id="ABB63668">
        <property type="protein sequence ID" value="ABB63668"/>
        <property type="gene ID" value="SDY_3707"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3707"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4400"/>
    <dbReference type="HOGENOM" id="CLU_053657_0_0_6"/>
    <dbReference type="OMA" id="HAHQCLR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="165"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="417" mass="46630" checksum="1FA5DBF91E58338B" modified="2005-12-06" version="1">MTFSLFGDKFTRHSGITLLMEDLNDGLRTPGAIMLGGGNPAQIPEMQDYFQTLLTDMLESGKATDALCNYDGSQGKTELLTLLAGMLREKLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGRVKKVLFPLAPEYIGYADAGLEEDLFVSARPNIELLPEGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELLKLDALANQHGIPLVIDNAYGVPFPGIIFSEARPLWNPNIVLCMSLSKLGLPGSRCGIIIANEKIITAITNMNGIISLAPGGIGPAMMCEMIKRNDLLRLSGTVIKPFYYQRVQETIAIIRRYLPENRCLIHKPEGAIFLWLWFKDLPITTEQLYQRLKARGVLMVPGHNFFPGLDKPWPHTHQCMRMNYVPEPEKIEAGVKILAEEIERAWAESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AS4</accession>
    <name>Q32AS4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PanD regulatory factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhhK</name>
        <name evidence="1" type="synonym">panZ</name>
        <name evidence="3" type="ordered locus">SDY_3610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with PanD in the presence of CoA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PanZ/PanM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000778769.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405072.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AS4"/>
    <dbReference type="STRING" id="300267.SDY_3610"/>
    <dbReference type="EnsemblBacteria" id="ABB63581">
        <property type="protein sequence ID" value="ABB63581"/>
        <property type="gene ID" value="SDY_3610"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3610"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4286"/>
    <dbReference type="HOGENOM" id="CLU_135649_0_0_6"/>
    <dbReference type="OMA" id="HFSDQDR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02018">
        <property type="entry name" value="PanZ_PanM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032900">
        <property type="entry name" value="PanZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040448">
        <property type="entry name" value="PanZ_GNAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12568">
        <property type="entry name" value="PanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="1">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="1">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="127" mass="14559" checksum="F5B54A30D294519A" modified="2005-12-06" version="1">MKLTIIRLEKFSDQDRIDLQKIWPEYSPSSLQVDDNHRIYAARFNERLLAAVRVTLSGTEGALDSLRVREVTRRRGVGQYLLEEVLRNNPGVSCWWMADAGVEDRGVMTAFMQALGFTAQQGGWEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AU1</accession>
    <name>Q32AU1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yhhW</name>
        <name evidence="5" type="ordered locus">SDY_3590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000639810.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405055.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AU1"/>
    <dbReference type="STRING" id="300267.SDY_3590"/>
    <dbReference type="EnsemblBacteria" id="ABB63564">
        <property type="protein sequence ID" value="ABB63564"/>
        <property type="gene ID" value="SDY_3590"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3590"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4263"/>
    <dbReference type="HOGENOM" id="CLU_064194_2_2_6"/>
    <dbReference type="OMA" id="ERGYADH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="261" mass="29606" checksum="96E4CE0F4ABFAFD3" modified="2005-12-06" version="1">MIYLRKANERGHANHGWLDSWHTFSFANYYDPNFMGFSALRVINDDVIEAGQGFGTHPHKDMEILTYVLEGTVEHQDSMGNKEQVPAGEFQIMSAGTGIRHSEYNPSSTERLHLYQIWIMPEENGITPRYEQRRFDAVQGKQLVLSPDARDGSLKVHQDMELYRWALLKDEQSVHQIAAERRVWIQVVKGNVTINGVKASTSDGLAIWDEQAISIHADSDSEVLLFDLPPLNDIFEACLFAGFLARSGRVLMYASGVLPRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AW3</accession>
    <name>USPB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Universal stress protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uspB</name>
        <name type="ordered locus">SDY_3568</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000626187.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405033.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AW3"/>
    <dbReference type="STRING" id="300267.SDY_3568"/>
    <dbReference type="EnsemblBacteria" id="ABB63542">
        <property type="protein sequence ID" value="ABB63542"/>
        <property type="gene ID" value="SDY_3568"/>
    </dbReference>
    <dbReference type="GeneID" id="67417128"/>
    <dbReference type="KEGG" id="sdy:SDY_3568"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4236"/>
    <dbReference type="HOGENOM" id="CLU_151816_0_0_6"/>
    <dbReference type="OMA" id="GGFFTAH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01088">
        <property type="entry name" value="UspB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019598">
        <property type="entry name" value="Universal_stress_protein_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10625">
        <property type="entry name" value="UspB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000064880" description="Universal stress protein B">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01088"/>
        </source>
    </evidence>
    <sequence length="111" mass="13027" checksum="BFD3813EDDD9CBFB" modified="2005-12-06" version="1">MISTVALFWALCVVCIVNMARYFSSLRALLVVLRNCDPLLYQYVDGGGFFTSHGQPNKQVRLVWYIYAQRYRDHHDDEFIRRCERVRRQFILTSALCGLVVVSLIALMIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AW8</accession>
    <name>Q32AW8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase J</fullName>
            <ecNumber evidence="1">2.1.1.266</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (adenine(2030)-N6)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m6A2030 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhiR</name>
        <name evidence="1" type="synonym">rlmJ</name>
        <name evidence="2" type="ordered locus">SDY_3563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the adenine in position 2030 of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43736"/>
            <dbReference type="Rhea" id="RHEA-COMP:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:10669"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.266"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RlmJ family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.266" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001313365.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405028.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AW8"/>
    <dbReference type="STRING" id="300267.SDY_3563"/>
    <dbReference type="EnsemblBacteria" id="ABB63537">
        <property type="protein sequence ID" value="ABB63537"/>
        <property type="gene ID" value="SDY_3563"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3563"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4230"/>
    <dbReference type="HOGENOM" id="CLU_061769_0_0_6"/>
    <dbReference type="OMA" id="TYAIWYP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036307">
        <property type="term" value="F:23S rRNA (adenine(2030)-N(6))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00934">
        <property type="entry name" value="23SrRNA_methyltr_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007473">
        <property type="entry name" value="RlmJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37426">
        <property type="entry name" value="PTHR37426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04378">
        <property type="entry name" value="RsmJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="1">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="280" mass="31961" checksum="AF4FEA797FCABF1F" modified="2005-12-06" version="1">MLSYRHSFHAGNHADVLKHTVQSLIIESLKEKDKPFLYLDTHAGAGRYQLGSEHAERTGEYLEGIARIWQQDDLPAELEAYINVVKHFNRSGQLRYYPGSPLIARQLLREQDSLQLTELHPSDYPLLRSEFQKDSRARVEKSDGFQQLKAKLPPVSRRGLILIDPPYEMKTDYQAVVSGIAEGYKRFATGTYALWYPVVLRQQIKRMIHDLEATGIRKILQIELAVLPDSDRRGMTASGMIVINPPWKLEQQMNNVLPWLHSKLVPAGTGHATVSWIVPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B26</accession>
    <name>EFG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor G</fullName>
            <shortName evidence="2">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fusA</name>
        <name type="ordered locus">SDY_3501</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000124700.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404970.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B26"/>
    <dbReference type="SMR" id="Q32B26"/>
    <dbReference type="STRING" id="300267.SDY_3501"/>
    <dbReference type="EnsemblBacteria" id="ABB63479">
        <property type="protein sequence ID" value="ABB63479"/>
        <property type="gene ID" value="SDY_3501"/>
    </dbReference>
    <dbReference type="GeneID" id="67416971"/>
    <dbReference type="KEGG" id="sdy:SDY_3501"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4155"/>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_6"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000225239" description="Elongation factor G">
        <location>
            <begin position="1"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="8"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <sequence length="704" mass="77581" checksum="8C72B9F87253BC7B" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BE7</accession>
    <name>RL21_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplU</name>
        <name type="ordered locus">SDY_3367</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000271401.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404849.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BE7"/>
    <dbReference type="SMR" id="Q32BE7"/>
    <dbReference type="STRING" id="300267.SDY_3367"/>
    <dbReference type="EnsemblBacteria" id="ABB63358">
        <property type="protein sequence ID" value="ABB63358"/>
        <property type="gene ID" value="SDY_3367"/>
    </dbReference>
    <dbReference type="GeneID" id="67415980"/>
    <dbReference type="KEGG" id="sdy:SDY_3367"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4021"/>
    <dbReference type="HOGENOM" id="CLU_061463_3_3_6"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000269380" description="50S ribosomal protein L21">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <sequence length="103" mass="11564" checksum="9221F104EC9C8CDB" modified="2005-12-06" version="1">MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETVEFAEVLMIANGEEVKIGVPFVDGGVIKAEVVAHGRGEKVKIVKFRRRKHYRKQQGHRQWFTDVKITGISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BG1</accession>
    <name>Q32BG1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alkaline phosphatase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yhbX</name>
        <name evidence="8" type="ordered locus">SDY_3352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BG1"/>
    <dbReference type="STRING" id="300267.SDY_3352"/>
    <dbReference type="EnsemblBacteria" id="ABB63344">
        <property type="protein sequence ID" value="ABB63344"/>
        <property type="gene ID" value="SDY_3352"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3352"/>
    <dbReference type="HOGENOM" id="CLU_039390_4_1_6"/>
    <dbReference type="OMA" id="ARRANWG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040423">
        <property type="entry name" value="PEA_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30443">
        <property type="entry name" value="PTHR30443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="7">
        <location>
            <begin position="188"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="505" mass="56675" checksum="4AADB2ED8BBB0BAC" modified="2005-12-06" version="1">MVQRLLFFVLTILVVKRISSLPLRQLVAAPFVLLTAADMSISLYSWCTFGTTFNDGFAISVLQSDPDEVVKMLGMYSPYLCAFSFLSLLFLAVIIKYDVSLPTKKVTGILLLIVISGSLFSACQFAYKDANNKNAFSPYILASRFATYTPFFNLNYFALAAKEHQRLLSIANTVPYFQLSVRDTGIDTYVLIVGESVRVDNMSLYGYTRSTTPQVEAQRKQIKLFNQAISGAPYTALSVPLSLTADSVLSHDIHNYPDNIINMANQAGFQTFWLSSQSAFRQNGTAVTSIAMRAMETVYVRGFDELLLPHLSQALQQNTQQKKLIVLHLNGSHEPACSAYPQSSAVFQPQDDQDACYDNSIHYTDSLLGQVFELLKDRRASVMYFADHGLERDPTKKNVYFHGGREASQQAYHVPMFIWYSPVLGDGVDRTTENNIFSTAYNNYLINAWMGVTKPEQPQTLEEVIAHYKGDSRVVDANHDVFDYVMLRKEFTEDKQGNPTPEGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BJ6</accession>
    <name>Q32BJ6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BJ6"/>
    <dbReference type="EnsemblBacteria" id="ABB63309">
        <property type="protein sequence ID" value="ABB63309"/>
        <property type="gene ID" value="SDY_3313"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3313"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_2_6"/>
    <dbReference type="OMA" id="YMICSLE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="58" mass="7030" checksum="8653BBC2F782A408" modified="2005-12-06" version="1">MPKNKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CC7</accession>
    <name>Q32CC7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PseudoU_synth_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yqcB</name>
        <name evidence="2" type="ordered locus">SDY_3008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000889996.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404519.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CC7"/>
    <dbReference type="STRING" id="300267.SDY_3008"/>
    <dbReference type="EnsemblBacteria" id="ABB63028">
        <property type="protein sequence ID" value="ABB63028"/>
        <property type="gene ID" value="SDY_3008"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3008"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3612"/>
    <dbReference type="HOGENOM" id="CLU_016902_11_4_6"/>
    <dbReference type="OMA" id="DRHETQF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="260" mass="29599" checksum="090B45A533DDB980" modified="2005-12-06" version="1">MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPSTRYGLVELEPKTGRKHQLRRHLAHLCHPIIGDSKHGDLRQNRSGAEHFGLKRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLLPENERVEFSAPSGQDGEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CC8</accession>
    <name>Q32CC8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_3007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000807753.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404518.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CC8"/>
    <dbReference type="SMR" id="Q32CC8"/>
    <dbReference type="STRING" id="300267.SDY_3007"/>
    <dbReference type="EnsemblBacteria" id="ABB63027">
        <property type="protein sequence ID" value="ABB63027"/>
        <property type="gene ID" value="SDY_3007"/>
    </dbReference>
    <dbReference type="GeneID" id="66673343"/>
    <dbReference type="KEGG" id="sdy:SDY_3007"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3611"/>
    <dbReference type="HOGENOM" id="CLU_051402_4_1_6"/>
    <dbReference type="OMA" id="SYDHFCG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="5">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="149" mass="16274" checksum="477B51ABB432999D" modified="2005-12-06" version="1">MAEIGIFVGTMYGNSLLVAEEAEAILTAQGHKATVFEDPELSDWLPYQDKYVLVVTSTTGQGDLPDSIVPLFQGIKDSLGFQPNLRYGVIALGDSSYVNFCNGGKQFDALLQEQSAQRVGEMLLIDASENPEPETESNPWVEQWGTLLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CG5</accession>
    <name>CYSH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoadenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="1">PAPS reductase</shortName>
            <ecNumber evidence="1">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PAPS sulfotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysH</name>
        <name type="ordered locus">SDY_2964</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite = 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000039858.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404481.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CG5"/>
    <dbReference type="SMR" id="Q32CG5"/>
    <dbReference type="STRING" id="300267.SDY_2964"/>
    <dbReference type="EnsemblBacteria" id="ABB62990">
        <property type="protein sequence ID" value="ABB62990"/>
        <property type="gene ID" value="SDY_2964"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2964"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3556"/>
    <dbReference type="HOGENOM" id="CLU_044089_3_0_6"/>
    <dbReference type="OMA" id="PIARWTQ"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000008937" description="Phosphoadenosine 5'-phosphosulfate reductase">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="1">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <sequence length="244" mass="27952" checksum="CC710DFC4101C719" modified="2005-12-06" version="1">MSKLDLNALNELPKVDRILALAETNAQLEKLDAEGRVAWALDNLPGEYVLSSSFGIQAAVSLHLVNQICPDIPVILTDTGYLFPETYRFIDELTDKLKLNLKVYRATESAAWQEARYGKLWEQGVEGIEKYNDINKVEPMNRALKELNAQTWFAGLRREQSGSRANLPVLAIQRGVFKVLPIIDWDNRTIYQYLQKHGLKYHPLWDEGYLSVGDTHTTRKWEPSMAEEETRFFGLKRECGLHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CR0</accession>
    <name>Q32CR0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ygaP</name>
        <name evidence="3" type="ordered locus">SDY_2858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001229452.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404386.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CR0"/>
    <dbReference type="STRING" id="300267.SDY_2858"/>
    <dbReference type="EnsemblBacteria" id="ABB62895">
        <property type="protein sequence ID" value="ABB62895"/>
        <property type="gene ID" value="SDY_2858"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2858"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3433"/>
    <dbReference type="HOGENOM" id="CLU_107126_1_0_6"/>
    <dbReference type="OMA" id="PRWDLER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
        <property type="entry name" value="DUF2892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="172" mass="18431" checksum="B2206F8F9913189C" modified="2005-12-06" version="1">MALTTISPHDAQELIARGAKLIDIRDADEYLREHIPEADLAPLSVLEQSGLPAKLRREQIIFHCQAGKRTSNNADKLAAIAAPAEIFLLEDGIDGWKKAGLPVAVNKSQPLPLMRQVQIAAGGLILIGVVLGYTVNSGFFLLSGFVGAGLLFAGISGFCGMARLLDKMPWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CU7</accession>
    <name>Q32CU7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 12">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">nadB</name>
        <name evidence="16" type="ordered locus">SDY_2815</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001094490.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404349.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CU7"/>
    <dbReference type="STRING" id="300267.SDY_2815"/>
    <dbReference type="EnsemblBacteria" id="ABB62858">
        <property type="protein sequence ID" value="ABB62858"/>
        <property type="gene ID" value="SDY_2815"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2815"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3391"/>
    <dbReference type="HOGENOM" id="CLU_014312_3_0_6"/>
    <dbReference type="OMA" id="HCVQWLI"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="14">
        <location>
            <begin position="10"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="15">
        <location>
            <begin position="441"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB62858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="540" mass="60278" checksum="EE0E87DA5824C73F" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CV5</accession>
    <name>ERA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">era</name>
        <name type="ordered locus">SDY_2807</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000020733.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404341.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CV5"/>
    <dbReference type="SMR" id="Q32CV5"/>
    <dbReference type="STRING" id="300267.SDY_2807"/>
    <dbReference type="EnsemblBacteria" id="ABB62850">
        <property type="protein sequence ID" value="ABB62850"/>
        <property type="gene ID" value="SDY_2807"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2807"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3382"/>
    <dbReference type="HOGENOM" id="CLU_038009_1_2_6"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000079735" description="GTPase Era">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Era-type G" evidence="2">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="206"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="2">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="2">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="2">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <sequence length="301" mass="33812" checksum="C43B3A76E6C1331F" modified="2005-12-06" version="1">MSIDKSYCGFIAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGIHTEGAYQAIYVDTPGLHMEEKRAINRLMNKAASSSIGDVELVIFVVEGTRWTLDDEMVLNKLRDGKAPVILAVNKVDNVQEKADLLPHLQFLASQMNFLDIVPISAETGLNVDTIAAIVRKHLPEATHHFPEDYITDRSQRFMASEIIREKLMRFLGAELPYSVTVEIERFVSNERGGYDINGLILVEREGQKKMVIGNKGAKIKTIGIEARKDMQEMFEAPVHLELWVKVKSGWADDERALRSLGYVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CX7</accession>
    <name>Q32CX7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrom_C_asm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404319.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CX7"/>
    <dbReference type="STRING" id="300267.SDY_2785"/>
    <dbReference type="EnsemblBacteria" id="ABB62828">
        <property type="protein sequence ID" value="ABB62828"/>
        <property type="gene ID" value="SDY_2785"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2785"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3356"/>
    <dbReference type="HOGENOM" id="CLU_049710_1_2_6"/>
    <dbReference type="OMA" id="MPGEFIT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="2">
        <location>
            <begin position="62"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="288" mass="32130" checksum="25A5468851AAC86F" modified="2005-12-06" version="1">MQRLEQRSPDAILLLFLIAQTVDITMPVFALLALVAYSVSLALIVPGLLQKNGGWRRMAIISAVIALVCHAIALEARILPDGDSGQNLSLLNVGSLVSLMICTVMTIVASRNRGWLLLPIVYAFALINLALATFMPNEYITHLEATPGMLVHIGLSLFSYATLIIAALYALQLAWIDYQLKNKKLAFNQEMPPLMSIERKMFHITQIGVVLLTLTLCTGLFYMHNLFSMENIDKAVLSIVAWFVYIVLLWGHYHEGWRGRRVVWFNVAGAVILTLAYFGSRIVQQLIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D33</accession>
    <name>ISCR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional regulator IscR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iscR</name>
        <name type="ordered locus">SDY_2727</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001241357.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404263.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D33"/>
    <dbReference type="SMR" id="Q32D33"/>
    <dbReference type="STRING" id="300267.SDY_2727"/>
    <dbReference type="EnsemblBacteria" id="ABB62772">
        <property type="protein sequence ID" value="ABB62772"/>
        <property type="gene ID" value="SDY_2727"/>
    </dbReference>
    <dbReference type="GeneID" id="60903810"/>
    <dbReference type="KEGG" id="sdy:SDY_2727"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3289"/>
    <dbReference type="HOGENOM" id="CLU_107144_0_0_6"/>
    <dbReference type="OMA" id="YGLTIMM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01176">
        <property type="entry name" value="HTH_type_IscR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010242">
        <property type="entry name" value="TF_HTH_IscR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02010">
        <property type="entry name" value="IscR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000268927" description="HTH-type transcriptional regulator IscR">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HTH rrf2-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="162" mass="17337" checksum="DE82977C3774E3BD" modified="2005-12-06" version="1">MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLRKNGLVSSVRGPGGGYLLGKDASSIAVGEVISAVDESVDATRCQGKGGCQGGDKCLTHALWRDLSDRLTGFLNNITLGELVNNQEVLDVSGRQHTHDAPRTRTQDAIDVKLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D78</accession>
    <name>Q32D78_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase 4 Fe-S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hyfI</name>
        <name evidence="3" type="ordered locus">SDY_2678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000075562.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404218.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D78"/>
    <dbReference type="STRING" id="300267.SDY_2678"/>
    <dbReference type="EnsemblBacteria" id="ABB62727">
        <property type="protein sequence ID" value="ABB62727"/>
        <property type="gene ID" value="SDY_2678"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2678"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3231"/>
    <dbReference type="HOGENOM" id="CLU_088839_0_0_6"/>
    <dbReference type="OMA" id="LRIYHAM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="44"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="252" mass="28101" checksum="6EA49EB9C0C31835" modified="2005-12-06" version="1">MSPVLTQHVSQPITLDEQTQKMKRHLLQDIRRSAYVYRVDCGGCNACEIEIFAAITPVFDAERFGIKVVSSPRHADILLFTGAVTRAMRMPALRAYESAPDHKICVSYGACGVGGGIFHDLYSVWGGSDTIVPIDVWLPGCPPTPAATIHGFAVALGLLQQKIHAVDYRDPTGVTMQPLWPQIPPSQRIAIEREARRLAGYRQGREICDRLLRHLSDDPTGNRVNTWLRDADDPRLNSIVQQLFRVLRGLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D79</accession>
    <name>Q32D79_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase 4 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hyfG</name>
        <name evidence="3" type="ordered locus">SDY_2676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001102278.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404217.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D79"/>
    <dbReference type="STRING" id="300267.SDY_2676"/>
    <dbReference type="EnsemblBacteria" id="ABB62726">
        <property type="protein sequence ID" value="ABB62726"/>
        <property type="gene ID" value="SDY_2676"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2676"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3228"/>
    <dbReference type="HOGENOM" id="CLU_015134_3_1_6"/>
    <dbReference type="OMA" id="RGENVHW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="40"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="297"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="461"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="571" mass="64997" checksum="A387D2F24E3CDCCB" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DB5</accession>
    <name>Q32DB5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_2636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404181.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DB5"/>
    <dbReference type="SMR" id="Q32DB5"/>
    <dbReference type="STRING" id="300267.SDY_2636"/>
    <dbReference type="EnsemblBacteria" id="ABB62690">
        <property type="protein sequence ID" value="ABB62690"/>
        <property type="gene ID" value="SDY_2636"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2636"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3174"/>
    <dbReference type="HOGENOM" id="CLU_064903_7_0_6"/>
    <dbReference type="OMA" id="WLIGGFK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020808">
        <property type="entry name" value="Bact_microcomp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032298">
        <property type="entry name" value="EutK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16365">
        <property type="entry name" value="EutK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01139">
        <property type="entry name" value="BMC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51933">
        <property type="entry name" value="EUTK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="3">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="EutK-Ctail" evidence="4">
        <location>
            <begin position="111"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="168" mass="18093" checksum="EE56B0BE868D72B6" modified="2005-12-06" version="1">MPMINALGLLEVDGMVAAIDAADAMLKAANVRLLSHEVLDPGRLTLVVEGDLAACRAALDAGCAAAMRTGRVISRKEIGRPDDDTQWLVTGFNRQPKQPVKEPDAPVIVAESADELLALLTSVRQGMTAGEVAAHFGWPLEKARNALEQLFSAGTLRKRSSRYRLKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DC3</accession>
    <name>Q32DC3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DC3"/>
    <dbReference type="EnsemblBacteria" id="ABB62682">
        <property type="protein sequence ID" value="ABB62682"/>
        <property type="gene ID" value="SDY_2628"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2628"/>
    <dbReference type="HOGENOM" id="CLU_203300_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="74" mass="8410" checksum="FDE58EE36F4C2EE3" modified="2005-12-06" version="1">MPKRITSSPVAHADVALICELDEQWSFVGSKARQHWLWYAYNTKTGGDWPTLLVPVPMKPAGNYWHCLRHSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DF2</accession>
    <name>Q32DF2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DF2"/>
    <dbReference type="EnsemblBacteria" id="ABB62653">
        <property type="protein sequence ID" value="ABB62653"/>
        <property type="gene ID" value="SDY_2592"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2592"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="10017" checksum="52CB270C953EB71D" modified="2005-12-06" version="1">MAVTAAKSVMAFRVMTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITQRTLQRRSSIITNGIRIVRWVIARHGNICGSGLVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DF4</accession>
    <name>Q32DF4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DF4"/>
    <dbReference type="EnsemblBacteria" id="ABB62651">
        <property type="protein sequence ID" value="ABB62651"/>
        <property type="gene ID" value="SDY_2590"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2590"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="242" mass="27447" checksum="2DE7C187C3D1E290" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAGTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DG8</accession>
    <name>Q32DG8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000825604.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404128.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DG8"/>
    <dbReference type="SMR" id="Q32DG8"/>
    <dbReference type="STRING" id="300267.SDY_2573"/>
    <dbReference type="EnsemblBacteria" id="ABB62637">
        <property type="protein sequence ID" value="ABB62637"/>
        <property type="gene ID" value="SDY_2573"/>
    </dbReference>
    <dbReference type="GeneID" id="66673755"/>
    <dbReference type="KEGG" id="sdy:SDY_2573"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3103"/>
    <dbReference type="HOGENOM" id="CLU_091661_1_0_6"/>
    <dbReference type="OMA" id="TETQYLM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021236">
        <property type="entry name" value="Uncharacterised_YfdX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10938">
        <property type="entry name" value="YfdX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220788" evidence="1">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="210" mass="22906" checksum="3CD0F825F6CC9018" modified="2005-12-06" version="1">MKRLIMATMVTAILASSTVWAADNAPVAAQQQTQQVQQTQKTAAAERISEQGLYAMRDVQVARLALFHGDPEKAKELTNEASALLSDDSTEWAKFAKPGKKTNLNDDQYIVINASVGISESYVATPEKEAAIKIANEKMAKGDKKGAMEELRLAGVGVMENQYLMPLKQTRNALADAQKLLDKKQYYEANLALKGAEDGIIVDSEALFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DI4</accession>
    <name>Q32DI4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_2553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404112.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DI4"/>
    <dbReference type="EnsemblBacteria" id="ABB62621">
        <property type="protein sequence ID" value="ABB62621"/>
        <property type="gene ID" value="SDY_2553"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2553"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3073"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="RTCARLW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14946" checksum="E025702D2C754B4A" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWLLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DM2</accession>
    <name>Q32DM2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein DedD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">dedD</name>
        <name evidence="4" type="ordered locus">SDY_2513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Non-essential cell division protein that could be required for efficient cell constriction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes at the septal ring.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SPOR domain binds septal peptidoglycans and is required to target DedD to the septal ring.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DedD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DM2"/>
    <dbReference type="STRING" id="300267.SDY_2513"/>
    <dbReference type="EnsemblBacteria" id="ABB62583">
        <property type="protein sequence ID" value="ABB62583"/>
        <property type="gene ID" value="SDY_2513"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2513"/>
    <dbReference type="HOGENOM" id="CLU_068683_1_1_6"/>
    <dbReference type="OMA" id="GYNAYIR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02022">
        <property type="entry name" value="DedD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032898">
        <property type="entry name" value="DedD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="129"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="211" mass="21876" checksum="15B6E43E9EA47F37" modified="2005-12-06" version="1">MGTIVLVALGVIVLPGLLDGQKKHYQDEFAAIPLVPKAGDRDEPDIMPAATQALPTQPPEGAAEEVRAGDAAAPSLDPATIAANNTEFEPEPAPVAPPKPKPVEPPKPKVEAPPAPKPEPQPVVEEKAAPTGKAYVVQLGALKNADKVNEIVGKLRGAGYRVYTSPSTPVQGKITRILVGPDASKDKLKGSLGELKQLSGLSGVVMGYTPN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DU5</accession>
    <name>GLPB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaerobic glycerol-3-phosphate dehydrogenase subunit B</fullName>
            <shortName evidence="1">Anaerobic G-3-P dehydrogenase subunit B</shortName>
            <shortName evidence="1">Anaerobic G3Pdhase B</shortName>
            <ecNumber evidence="1">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glpB</name>
        <name type="ordered locus">SDY_2437</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic G-3-P dehydrogenase subunit B family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001209957.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404001.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DU5"/>
    <dbReference type="STRING" id="300267.SDY_2437"/>
    <dbReference type="EnsemblBacteria" id="ABB62510">
        <property type="protein sequence ID" value="ABB62510"/>
        <property type="gene ID" value="SDY_2437"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2437"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2936"/>
    <dbReference type="HOGENOM" id="CLU_047793_0_0_6"/>
    <dbReference type="OMA" id="CFGLENQ"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00753">
        <property type="entry name" value="Glycerol3P_GlpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009158">
        <property type="entry name" value="G3P_DH_GlpB_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000141">
        <property type="entry name" value="Anaerobic_G3P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03378">
        <property type="entry name" value="glycerol3P_GlpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000258908" description="Anaerobic glycerol-3-phosphate dehydrogenase subunit B">
        <location>
            <begin position="1"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00753"/>
        </source>
    </evidence>
    <sequence length="419" mass="45423" checksum="D0B172214645EE48" modified="2005-12-06" version="1">MRFDTVIMGGGLAGLLCGLQLQKHGLRSAIVTRGQSALHFSSGSLDLLSHLPDGQAVTDIHSGLESLRQQAPAHPYSLLGPQRVLDLACQAQALIAKSGAQLQGSVELPHQRITPLGTLRSTWLSSPEVPVWPLPAKKICVVGISGLMDFQAHLAAASLRELDLAVETAEIELPELDVLRNNATEFRAVNIARFLDNEENWPLLLDALIPVANTCEMILIPACFGLADDKLWRWLNEKLPCSLMLLPTLPPSVLSIRLQNQLQRQFVRQGGVWMPGDEVKKVTCKNGVVNEIWTRNHADIPLRPRFAVLASGSFFSGGLVAERNGIREPILGLDVLQTATRGEWYKEDFFAPQPWQQFGVTTDQTLRPSQAGQTIENLFAIGSVLGGFDPIAQGCGGGVCAVSALHAAQQIAQRAGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DW7</accession>
    <name>Q32DW7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative antirepressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DW7"/>
    <dbReference type="EnsemblBacteria" id="ABB62488">
        <property type="protein sequence ID" value="ABB62488"/>
        <property type="gene ID" value="SDY_2415"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2415"/>
    <dbReference type="HOGENOM" id="CLU_046670_14_2_6"/>
    <dbReference type="OMA" id="CHDYGHE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018873">
        <property type="entry name" value="KilA-N_DNA-bd_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018876">
        <property type="entry name" value="Phage_P22_antirepressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10543">
        <property type="entry name" value="ORF6N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10548">
        <property type="entry name" value="P22_AR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORF6N" evidence="1">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="P22_AR_C" evidence="2">
        <location>
            <begin position="187"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="287" mass="32781" checksum="609F114BD0CDF474" modified="2005-12-06" version="1">MRRARVFFISFAQSHSRFMVGCVGEPKGSPVSVPGSLNPAQLATRLLRPEGGDNDQMYGVIVMLTQISVDTLPAITHNQIRVITTELLAQLYGTKIKNISDNFLNNTMRFVVGKHYFKIEKNELREFKNRPETIGLVGKNARSLILWTERGAARHAKMLETDQAWDVFEKLEDCYFSQTSKSAGHHEKKTSELSAKDANSLVWLWDYANRSQALFRELYPALRQIQSNYSGRCHDYGHEFSYVIGMARDVLINHTRDVDINEPDGPTNLSAWVRLKNKELPPSLHHY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E16</accession>
    <name>YCAD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uncharacterized MFS-type transporter YcaD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycaD</name>
        <name type="ordered locus">SDY_2363</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000109295.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403930.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E16"/>
    <dbReference type="SMR" id="Q32E16"/>
    <dbReference type="STRING" id="300267.SDY_2363"/>
    <dbReference type="EnsemblBacteria" id="ABB62439">
        <property type="protein sequence ID" value="ABB62439"/>
        <property type="gene ID" value="SDY_2363"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2363"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2854"/>
    <dbReference type="HOGENOM" id="CLU_035018_1_2_6"/>
    <dbReference type="OMA" id="IGIGDHM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01149">
        <property type="entry name" value="MFS_YcaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023745">
        <property type="entry name" value="MFS_YcaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000065496" description="Uncharacterized MFS-type transporter YcaD">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01149"/>
        </source>
    </evidence>
    <sequence length="382" mass="41460" checksum="9C7DD6792878C856" modified="2005-12-06" version="1">MSTYTRPVMLLLSGLLLLTLAIAVLNTLVPLWLAQEHMSTWQVGVVSSSYFTGNLVGTLLTGYVIKRIGFNRSYYLASFIFAAGCAGLGLMIGFWSWLAWRFVAGVGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYVGTFLGQLLVSKVSTELMSVLPWVTGLTLAGILPLLFTRVLNQQAENHDSTSITSMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLNHKGVSNASIGFWMAVLVSAGILGQWPIGRLADKFGRLLVLRVQVFVVILGSIAMLSQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFTAMLMQNFSDNLLFIMIASVSFIYLLMLLRNAGHTPKPVAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EB3</accession>
    <name>Q32EB3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactitol utilization operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gatR</name>
        <name evidence="5" type="ordered locus">SDY_2262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000178558.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403833.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EB3"/>
    <dbReference type="STRING" id="300267.SDY_2262"/>
    <dbReference type="EnsemblBacteria" id="ABB62342">
        <property type="protein sequence ID" value="ABB62342"/>
        <property type="gene ID" value="SDY_2262"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2262"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2731"/>
    <dbReference type="HOGENOM" id="CLU_060699_0_1_6"/>
    <dbReference type="OMA" id="LATVDHW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="259" mass="27944" checksum="5FAB734087151DF0" modified="2005-12-06" version="1">MTMNSFERRNKIIQLVNEQGTVLVQDLAGVFAASEATIRADLRFLEQKGVVTRFHGGAAKIMSGNSETETQEVGFKERFQLASAPKNRIAQAAVKMIHEGMTVILDSGSTTMLIAKGLMTAKNITVITNSLPAAFALSENKDITLVVCGGTVRHKTRSMHGSIAERSLQDINADLMFVGADGIDAVNGITTFNEGYSISGAMVTAANKVIAVLDSSKFNRRGFNQVLPIEKIDIIITDDAVSDVDKLALQKTRVKLITV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EF3</accession>
    <name>HIS4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="1">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisA</name>
        <name type="ordered locus">SDY_2217</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EF3"/>
    <dbReference type="SMR" id="Q32EF3"/>
    <dbReference type="STRING" id="300267.SDY_2217"/>
    <dbReference type="EnsemblBacteria" id="ABB62302">
        <property type="protein sequence ID" value="ABB62302"/>
        <property type="gene ID" value="SDY_2217"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2217"/>
    <dbReference type="HOGENOM" id="CLU_048577_1_2_6"/>
    <dbReference type="OMA" id="EWLHLVD"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000229082" description="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <sequence length="246" mass="26146" checksum="4CD99D4B4C049E49" modified="2005-12-06" version="1">MMIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSPEMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDINDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EM3</accession>
    <name>CDD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidine deaminase</fullName>
            <ecNumber evidence="1">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine aminohydrolase</fullName>
            <shortName evidence="1">CDA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cdd</name>
        <name type="ordered locus">SDY_2144</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000553543.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403723.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EM3"/>
    <dbReference type="SMR" id="Q32EM3"/>
    <dbReference type="STRING" id="300267.SDY_2144"/>
    <dbReference type="EnsemblBacteria" id="ABB62232">
        <property type="protein sequence ID" value="ABB62232"/>
        <property type="gene ID" value="SDY_2144"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2144"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2591"/>
    <dbReference type="HOGENOM" id="CLU_052424_0_0_6"/>
    <dbReference type="OMA" id="NYSPCGH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01558">
        <property type="entry name" value="Cyt_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013171">
        <property type="entry name" value="Cyd/dCyd_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006263">
        <property type="entry name" value="Cyt_deam_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020797">
        <property type="entry name" value="Cytidine_deaminase_bacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08211">
        <property type="entry name" value="dCMP_cyt_deam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01355">
        <property type="entry name" value="cyt_deam_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000171666" description="Cytidine deaminase">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase 1" evidence="2">
        <location>
            <begin position="48"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase 2" evidence="2">
        <location>
            <begin position="186"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01083"/>
        </source>
    </evidence>
    <sequence length="294" mass="31497" checksum="6E019C2DBF41C224" modified="2005-12-06" version="1">MHPRFQTAFAQLADNLQSALEPILADKYFPALLTGEQVSSLKSATGLDEDALAFALLPLAAACALTPLSNFNVGAIARGVSGTWYFGANMEFIGATMQQTVHAEQSAISHAWLSGEKALAAITVNYTPCGHCRQFMNELNSGLDLRIHLPGREAHALRDYLPDAFGPKDLEIKTLLMDEQDHGYALTGDALSQAAIAAANRSHMPYSKSPSGVALECKDGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQWDATSATLKALGCHSIDRVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EN6</accession>
    <name>Q32EN6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mgl repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">galS</name>
        <name evidence="5" type="ordered locus">SDY_2129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000628676.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403710.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EN6"/>
    <dbReference type="STRING" id="300267.SDY_2129"/>
    <dbReference type="EnsemblBacteria" id="ABB62219">
        <property type="protein sequence ID" value="ABB62219"/>
        <property type="gene ID" value="SDY_2129"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2129"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2568"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_6"/>
    <dbReference type="OMA" id="RFFAEPY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="346" mass="37447" checksum="E136A432065E0C3D" modified="2005-12-06" version="1">MITIRDVARQAGVSVATVSRVLNNSTLVSADTREAVMKAVSELDYRPNANAQALATQVSDTIGVVVMDVSDAFFGALVKAVDLVVQQHQKYMLIGNSYHEAEKERHAIEVLIRQRCNALIVHSKALSDDELAQFMDNIPGMVLINRVVPGYAHRCVCLDNLSGARMATRMLLNNGHQRIGYLSSSHGIEDDAMRKAGWMSALKEQDIIPPESWIGTGTPDMPGGEAAMVELLGRNLQLTAVFAYNDNMAAGALTALKDNGIAIPLHLSIIGFDDIPIARYTDPQLTTVRYPIASMAKLATELALQGAAGNIDPRASHCFMPTLVRRHSVATRQNAAAITNSTNQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EW5</accession>
    <name>Q32EW5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Penicillin-binding protein activator LpoB</fullName>
            <shortName evidence="5">PBP activator LpoB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ycfM</name>
        <name evidence="5" type="synonym">lpoB</name>
        <name evidence="8" type="ordered locus">SDY_2045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with PBP1b.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the LpoB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000164439.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403631.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EW5"/>
    <dbReference type="SMR" id="Q32EW5"/>
    <dbReference type="STRING" id="300267.SDY_2045"/>
    <dbReference type="EnsemblBacteria" id="ABB62140">
        <property type="protein sequence ID" value="ABB62140"/>
        <property type="gene ID" value="SDY_2045"/>
    </dbReference>
    <dbReference type="GeneID" id="66670629"/>
    <dbReference type="KEGG" id="sdy:SDY_2045"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2459"/>
    <dbReference type="HOGENOM" id="CLU_092328_0_0_6"/>
    <dbReference type="OMA" id="AMQPMVG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031241">
        <property type="term" value="C:periplasmic side of cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01889">
        <property type="entry name" value="LpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014094">
        <property type="entry name" value="LpoB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40593">
        <property type="entry name" value="PTHR40593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13036">
        <property type="entry name" value="LpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02722">
        <property type="entry name" value="lp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="1 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="2 5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008969459" description="Penicillin-binding protein activator LpoB" evidence="7">
        <location>
            <begin position="24"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="213" mass="22516" checksum="06B529F3F4722AD7" modified="2005-12-06" version="1">MTKMSRYALITALAMFLAGCVGQREPAPVEEVKPAPEQPAEPQQPVPTVPSVPTIPQQPGPIEHEDQTAPPAPHIRHYDWNGAMQPMVSKMLGADGVTAGSVLLVDSVNNRTNGSLNAAEATETLRNALANNGKFTLVSAQQLSMAKQQLGLSPQDSLGTRSKAIGIARNVGAHYVLYSSASGNVNAPTLQMQLMLVQTGEIIWSGKGAVSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F84</accession>
    <name>Q32F84_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage Mu Mom-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403512.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F84"/>
    <dbReference type="EnsemblBacteria" id="ABB62021">
        <property type="protein sequence ID" value="ABB62021"/>
        <property type="gene ID" value="SDY_1915"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1915"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2306"/>
    <dbReference type="HOGENOM" id="CLU_080940_0_0_6"/>
    <dbReference type="OMA" id="RRNIVGK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="245" mass="28678" checksum="CEEC36B803EDE307" modified="2005-12-06" version="1">MPASIPRRNIVGKEKKSRILTKPCVIEYEGQIVGYGSKELHVETISCWLARTIIQTKHYSRRFVNNSYLHLGVFSGRDLVGVLQWGYALNPNSGRRVVLETDNRGYMELNRMWLHDNMPRNSESRAISYALKTIRLLYPSVEWVQSFADERCGRAGVVYQASNFDFIGSHESTFYELDGEWYHEITMNAMKRGGQRGVYLRANKERAVVHKFNQYRYIRFLNKRARKRLNTKLFKVQPYPKSTPD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FF0</accession>
    <name>ADD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenosine deaminase</fullName>
            <ecNumber evidence="1">3.5.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Adenosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">add</name>
        <name type="ordered locus">SDY_1846</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:28190"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:28191"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000567473.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403446.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FF0"/>
    <dbReference type="SMR" id="Q32FF0"/>
    <dbReference type="STRING" id="300267.SDY_1846"/>
    <dbReference type="EnsemblBacteria" id="ABB61955">
        <property type="protein sequence ID" value="ABB61955"/>
        <property type="gene ID" value="SDY_1846"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1846"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2225"/>
    <dbReference type="HOGENOM" id="CLU_039228_0_2_6"/>
    <dbReference type="OMA" id="NHFTIHA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046936">
        <property type="term" value="F:2'-deoxyadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00540">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028893">
        <property type="entry name" value="A_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000017705" description="Adenosine deaminase">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00540"/>
        </source>
    </evidence>
    <sequence length="333" mass="36406" checksum="C4084FD56EDA7B23" modified="2005-12-06" version="1">MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAHSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVIDGVREGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHRDQITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQIGIESCLTSNIQTSTVAELAAHPLKTFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSAEEKRALREKVAAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FL5</accession>
    <name>AZOR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN-dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="1">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="1">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">azoR</name>
        <name type="ordered locus">SDY_1775</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="1"/>
    <dbReference type="EC" id="1.7.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000048980.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403381.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FL5"/>
    <dbReference type="SMR" id="Q32FL5"/>
    <dbReference type="STRING" id="300267.SDY_1775"/>
    <dbReference type="EnsemblBacteria" id="ABB61890">
        <property type="protein sequence ID" value="ABB61890"/>
        <property type="gene ID" value="SDY_1775"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1775"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2139"/>
    <dbReference type="HOGENOM" id="CLU_088964_0_0_6"/>
    <dbReference type="OMA" id="AGITFKY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000245971" description="FMN-dependent NADH:quinone oxidoreductase">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <sequence length="201" mass="21608" checksum="B52E3AD64A1F4F2C" modified="2005-12-06" version="1">MSKVLVLKSSILAGYSQSNQLSDYLVEQWREKHSADEITVRDLAANPIPVLDGELVGALRPSDAPLTPRQQEALALSDELIAELKAHDVIVIAAPMYNFNISTQLKNYFDLVARAGVTFRYTENGPEGLVTGKKAIVITSRGGIHKDGPTDLVTPYLSTFLGFIGITDVKFVFAEGIAYGPEMAAKAQSDAKAAIDSIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FQ2</accession>
    <name>Q32FQ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000760650.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403344.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FQ2"/>
    <dbReference type="STRING" id="300267.SDY_1735"/>
    <dbReference type="EnsemblBacteria" id="ABB61853">
        <property type="protein sequence ID" value="ABB61853"/>
        <property type="gene ID" value="SDY_1735"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1735"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2093"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_6"/>
    <dbReference type="OMA" id="MRLNFTY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="468" mass="52809" checksum="477B7B3B2904179B" modified="2005-12-06" version="1">MKKYQQLAEQLREQIASGIWQPGDRLPSLRDQVALSGMSFMTVSHAYQLLESQGYIIARPQSGYYVAPQAIKMPKVPVIPVTRDEAVDINTYIFDMLQASRDPSVVPFASAFPDPRLFPLQQLNRSLAQVSKNATAMSVIENLPPGNAELRQAIARRYVLQGITISPDEIVITAGALEALNLSLQAVTEPGDWVIVENPCFYGALQALERLRLKALSVATDVKEGIDLQALELALQEYPVKACWLMTNSQNPLGFTLTPQKKAQLVALLNQYNVTLIEDDVYSELYFGREKPLPAKAWDCHDGVLHCSSFSKCLVPGFRIGWVAAGKHARKIQRLQLMSTLSTSSPMQLALVDYLSTRRYDAHLRRLRRQLAERKQRAWQALLRYLPAEVKIHHNDSGYFLWLELPEPLDAGELSLAALTHHISIAPGKMFSTGENWSRFFRFNTAWQWGEREEQAVKQLGKLIQERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FS6</accession>
    <name>Q32FS6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fadD</name>
        <name evidence="4" type="ordered locus">SDY_1709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000758422.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403320.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FS6"/>
    <dbReference type="SMR" id="Q32FS6"/>
    <dbReference type="STRING" id="300267.SDY_1709"/>
    <dbReference type="EnsemblBacteria" id="ABB61829">
        <property type="protein sequence ID" value="ABB61829"/>
        <property type="gene ID" value="SDY_1709"/>
    </dbReference>
    <dbReference type="GeneID" id="66674306"/>
    <dbReference type="KEGG" id="sdy:SDY_1709"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2063"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_9_6"/>
    <dbReference type="OMA" id="KQSDMKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="469"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="561" mass="62332" checksum="249B0AA54B3DBFA5" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FY9</accession>
    <name>Q32FY9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FY9"/>
    <dbReference type="EnsemblBacteria" id="ABB61766">
        <property type="protein sequence ID" value="ABB61766"/>
        <property type="gene ID" value="SDY_1642"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1642"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15392" checksum="165065E194A58A25" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTRRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G42</accession>
    <name>Q32G42_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000214712.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403204.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G42"/>
    <dbReference type="STRING" id="300267.SDY_1584"/>
    <dbReference type="EnsemblBacteria" id="ABB61713">
        <property type="protein sequence ID" value="ABB61713"/>
        <property type="gene ID" value="SDY_1584"/>
    </dbReference>
    <dbReference type="GeneID" id="66674598"/>
    <dbReference type="KEGG" id="sdy:SDY_1584"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1903"/>
    <dbReference type="HOGENOM" id="CLU_189992_0_0_6"/>
    <dbReference type="OMA" id="VMINGTG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017704">
        <property type="entry name" value="Se-bd_putative_YdfZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14001">
        <property type="entry name" value="YdfZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03318">
        <property type="entry name" value="YdfZ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7276" checksum="CF996187C82C8021" modified="2005-12-06" version="1">MTTYDRNRNAITTGSRVMVSGTGHTGKILSIDTEGLTAEQIRRGKTVVVEGCEEKLAPLDLIRLGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G80</accession>
    <name>Q32G80_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative excinuclease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000252406.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403166.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G80"/>
    <dbReference type="STRING" id="300267.SDY_1539"/>
    <dbReference type="EnsemblBacteria" id="ABB61675">
        <property type="protein sequence ID" value="ABB61675"/>
        <property type="gene ID" value="SDY_1539"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1539"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1844"/>
    <dbReference type="HOGENOM" id="CLU_054721_1_0_6"/>
    <dbReference type="OMA" id="RVMSHFR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="288" mass="33000" checksum="73E6A0F5247A4EAD" modified="2005-12-06" version="1">MVRRLTSPRLEFEAAAIYEYPEHLRSFLNDLPTRPGVYLFHGESDTMPLYIGKSVNIRSRVRSHLRPPDEAAMLRQSRRISWICTAGEIGALLLEARLIKEQQPLFNKRLRRNRQLCALQLNEKRVDVVYAKEVDFSRAPNLFGLFANRRAALQALQSIADEQKLCYGLLGLEPLSRGRACFRSALKRCAGACCGKESHEEHALHLRQSLERLRVVCWPWQGAVALKEQHPEMTQYHIIQNWLWLGAVTLIRTPAGFDHDGYKILCKPLLSGNYEITELDPANDQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G92</accession>
    <name>Q32G92_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydjX</name>
        <name evidence="2" type="ordered locus">SDY_1526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403154.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G92"/>
    <dbReference type="STRING" id="300267.SDY_1526"/>
    <dbReference type="EnsemblBacteria" id="ABB61663">
        <property type="protein sequence ID" value="ABB61663"/>
        <property type="gene ID" value="SDY_1526"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1526"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1826"/>
    <dbReference type="HOGENOM" id="CLU_038944_7_1_6"/>
    <dbReference type="OMA" id="VGPWFPL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="187" mass="20715" checksum="1214ABF3C48620ED" modified="2005-12-06" version="1">MNAERKFLFACLIFALVIYTIHAFGLFDLLTDLPHLQTLIRQNGLFGYSLYILLFIIATLFLLPGSILVIAGGIVFGPFLGTLLSLIAATLASSCSFLLARWMGRDLLLKYVGHSHTFQAIEKSIARNGIDFLILTRLIPLFPYNIQNYAYGLTTIAFWPYTLISALTTLPGIVIYTVMASDLANEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GP3</accession>
    <name>Q32GP3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yciW</name>
        <name evidence="1" type="ordered locus">SDY_1367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GP3"/>
    <dbReference type="STRING" id="300267.SDY_1367"/>
    <dbReference type="EnsemblBacteria" id="ABB61512">
        <property type="protein sequence ID" value="ABB61512"/>
        <property type="gene ID" value="SDY_1367"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1367"/>
    <dbReference type="HOGENOM" id="CLU_057689_0_0_6"/>
    <dbReference type="OMA" id="NHWYHET"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="333" mass="37375" checksum="2CD4A4E7653639C0" modified="2005-12-06" version="1">MILEKETLAPFLSWLGPARVLAVDLFPDQLTVTRSQTFTAYERLSTALTVAQVCGVQRLCNYYSARLTPLPGPDSTRESNHRLAQITQYARQLASSPSIIDNRSRQHLNDVGLTAWDCVIINQIIGFIGFQARTIATFQAYLGHPVRWLPGLEIQNYADASLFADESLRWRSSYEVEELPEEHTKSSTAELCQLAEILSLHPISLSLLERLLNSTRVNTQPDNQLAALLCARINGSPACFAACMDSSNEYKKISTLLRKGENEINQWADRHSVERATVQAIQWLTRAPDRFSAAQFGPLLEHEKSSTQIINLLVWSGLCGWINRLKIALGETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GW6</accession>
    <name>Q32GW6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS4 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402930.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GW6"/>
    <dbReference type="STRING" id="300267.SDY_1292"/>
    <dbReference type="EnsemblBacteria" id="ABB61439">
        <property type="protein sequence ID" value="ABB61439"/>
        <property type="gene ID" value="SDY_1292"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1292"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1533"/>
    <dbReference type="HOGENOM" id="CLU_028400_1_1_6"/>
    <dbReference type="OMA" id="VEQELWV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024473">
        <property type="entry name" value="Transposases_IS4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13006">
        <property type="entry name" value="Nterm_IS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nterm_IS4" evidence="2">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="377" mass="43254" checksum="AB7D415F1EB2AE1B" modified="2005-12-06" version="1">MFPDFFMHIGQALDLVSRYDSLRNPLTSLGDYLDPELISRCLAESGTVTLRKRRLPLEMMVWCIVGMVLERKEPLHQIVNRLDIMLPGNCPFVAPSAVIQARQRLGSEAVRRVFTKTVQLWHNATPHPHWCGLTLLAIDGVFWRTPDTPENDAAFPRQTHAGNPALYPQVKMVCQMELTSHLLTAAAFGTMKNSENELAEQLIEQTGDNTLTLMDKGYYSLGLLNAWSLAGEHRHWMIPLRKRAQYEEIRKLGKGDHLVKLKTSPQARKKWPGLGNEVTARLLTVTRKGKVCHLLTSMTDAMRFPGGEMADLYSHRWEIELGYREIKQTMQLSRLTLRSKKPELVEQELWGVLLAYNLVRYQMIKMAEHLKGYWPNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GZ9</accession>
    <name>ISPE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="1">CMK</shortName>
            <ecNumber evidence="1">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispE</name>
        <name type="ordered locus">SDY_1257</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001260351.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402897.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GZ9"/>
    <dbReference type="SMR" id="Q32GZ9"/>
    <dbReference type="STRING" id="300267.SDY_1257"/>
    <dbReference type="EnsemblBacteria" id="ABB61406">
        <property type="protein sequence ID" value="ABB61406"/>
        <property type="gene ID" value="SDY_1257"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1257"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1494"/>
    <dbReference type="HOGENOM" id="CLU_053057_3_0_6"/>
    <dbReference type="OMA" id="RWPSPAK"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000235130" description="4-diphosphocytidyl-2-C-methyl-D-erythritol kinase">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <sequence length="283" mass="30952" checksum="E4145BFB36047672" modified="2005-12-06" version="1">MRTQWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTISIELRDNGDIRLLTPVEGVEHEDNLIVRAARLLMKTAADSGRLPTGSGANISIDKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSMDELAEMGLTLGADVPVFVRGHAAFAEGVGEILTPVDPPEKWYLVAHPGVSIPTPVIFKDPELPRNTPKRSIETLLKCEFSNDCEVIARKRFREVDAVLSWLLEYAPSRLTGTGACVFAEFDTESEARQVLEQAPEWLNGFVAKGVNLSPLHRAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H21</accession>
    <name>Q32H21_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellar brake protein YcgR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cyclic di-GMP binding protein YcgR</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">ycgR</name>
        <name evidence="4" type="ordered locus">SDY_1233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Interacts with the flagellar basal bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YcgR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000020123.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402875.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H21"/>
    <dbReference type="STRING" id="300267.SDY_1233"/>
    <dbReference type="EnsemblBacteria" id="ABB61384">
        <property type="protein sequence ID" value="ABB61384"/>
        <property type="gene ID" value="SDY_1233"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1233"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1463"/>
    <dbReference type="HOGENOM" id="CLU_086025_1_0_6"/>
    <dbReference type="OMA" id="REYFRVN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071945">
        <property type="term" value="P:regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01457">
        <property type="entry name" value="YcgR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023787">
        <property type="entry name" value="T3SS_YcgR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009926">
        <property type="entry name" value="T3SS_YcgR_PilZN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07317">
        <property type="entry name" value="YcgR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="1" id="KW-0973">c-di-GMP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T3SS_YcgR_PilZN" evidence="3">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ" evidence="2">
        <location>
            <begin position="112"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="244" mass="27819" checksum="0CB75AB638946A7E" modified="2005-12-06" version="1">MSHYHEQFLKQNPLAALGVLRDLHKAAIPLRLSWIGGQLISKILVITPDKLVLDFGSQAEDNIAVLKAQYITITAETQGAKVEFTVEQLQQSEYLQLPAFITVPPPTLWFVQRRRYFRISAPLHPPYFCQTKLADNSTLRFRLYDLSLGGMGALLETAKPAGLHEGMRFAQIEVNMGQWGVFHFDAQLISISERKVIDGKNETITTPRLSFRFLNVSPTVERQLQRIIFSLEREAREKADKVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H46</accession>
    <name>Q32H46_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Septum site-determining protein MinD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division inhibitor MinD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">minD</name>
        <name evidence="12" type="ordered locus">SDY_1206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with MinC and FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000101055.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402850.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H46"/>
    <dbReference type="SMR" id="Q32H46"/>
    <dbReference type="STRING" id="300267.SDY_1206"/>
    <dbReference type="EnsemblBacteria" id="ABB61359">
        <property type="protein sequence ID" value="ABB61359"/>
        <property type="gene ID" value="SDY_1206"/>
    </dbReference>
    <dbReference type="GeneID" id="66675005"/>
    <dbReference type="KEGG" id="sdy:SDY_1206"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1429"/>
    <dbReference type="HOGENOM" id="CLU_037612_0_1_6"/>
    <dbReference type="OMA" id="CESAKAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010223">
        <property type="entry name" value="MinD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01968">
        <property type="entry name" value="minD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="11">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB61359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="270" mass="29614" checksum="0D2C4C0976B77D2C" modified="2005-12-06" version="1">MARIIVVTSGKGGVGKTTSSAAIATGLAQKGKKTVVIDFDIGLRNLDLIMGCERRVVYDFVNVIQGDATLNQALIKDKRTENLYILPASQTRDKDALTREGVAKVLDDLKAMDFEFIVCDSPAGIETGALMALYFADEAIITTNPEVSSVRDSDRILGILASKSRRAENGEEPIKEHLLLTRYNPGRVSRGDMLSMEDVLEILRIKLVGVIPEDQSVLRASNQGEPVILDINADAGKAYADTVERLLGEERPFRFIEEEKKGFLKRLFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HD4</accession>
    <name>Q32HD4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001237866.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402762.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HD4"/>
    <dbReference type="STRING" id="300267.SDY_1114"/>
    <dbReference type="EnsemblBacteria" id="ABB61271">
        <property type="protein sequence ID" value="ABB61271"/>
        <property type="gene ID" value="SDY_1114"/>
    </dbReference>
    <dbReference type="GeneID" id="58461792"/>
    <dbReference type="KEGG" id="sdy:SDY_1114"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1309"/>
    <dbReference type="HOGENOM" id="CLU_145367_0_0_6"/>
    <dbReference type="OMA" id="QAMLQNA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025731">
        <property type="entry name" value="YecR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13992">
        <property type="entry name" value="YecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="107" mass="11755" checksum="DC68CD50B0B3FCAA" modified="2005-12-06" version="1">MRLLILTLSLITLAGCTVTRQAHVSEVDAATGIVRLVYDQAFLQHAHTDRYVSRGIADRACQQEGYTHAIPFGQPVGNCSLFAGSLCLNTEFTLSYQCHHSAFPVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HD7</accession>
    <name>Q32HD7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aromatic amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tyrP</name>
        <name evidence="11" type="ordered locus">SDY_1111</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in transporting aromatic amino acids across the cytoplasmic membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell inner membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000797563.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402759.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HD7"/>
    <dbReference type="STRING" id="300267.SDY_1111"/>
    <dbReference type="EnsemblBacteria" id="ABB61268">
        <property type="protein sequence ID" value="ABB61268"/>
        <property type="gene ID" value="SDY_1111"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1111"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1305"/>
    <dbReference type="HOGENOM" id="CLU_038102_3_0_6"/>
    <dbReference type="OMA" id="PHIHQVN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015173">
        <property type="term" value="F:aromatic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018227">
        <property type="entry name" value="Amino_acid_transport_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013061">
        <property type="entry name" value="Trp/try_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013059">
        <property type="entry name" value="Trp_tyr_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46997">
        <property type="entry name" value="PTHR46997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03222">
        <property type="entry name" value="Trp_Tyr_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00166">
        <property type="entry name" value="AROAAPRMEASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00837">
        <property type="entry name" value="araaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00594">
        <property type="entry name" value="AROMATIC_AA_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB61268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="403" mass="42837" checksum="770D93BC2FA5C092" modified="2005-12-06" version="1">MKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFSVTLILLIGLWALMCYTALLLLEVYQHVPADTGLGTLAKRYLGRYGQWLTGFSMMFLMYALTAAYISGAGELLASSISDWTGISMSATAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVVMLVLLLPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMDGNIRKLRWVFITGSAIPLAAYIFWQVATLGSIDSTTFMGLLANHAGLNGLLQALREMVASPHVELAVHLFADLALATSFLGVALGLFDYLADLFQRSNTVGGRLQTGAITFLPPLAFALFYPRGFVMALGYAGVALAVLALIIPSLLTWQSRKHNPQAGYRVKGDRPALVVVFLCGIAVIGVQFLIAAGLLPEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HM4</accession>
    <name>Q32HM4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402672.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HM4"/>
    <dbReference type="EnsemblBacteria" id="ABB61181">
        <property type="protein sequence ID" value="ABB61181"/>
        <property type="gene ID" value="SDY_1016"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1016"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1185"/>
    <dbReference type="HOGENOM" id="CLU_095516_2_0_6"/>
    <dbReference type="OMA" id="IWFGETG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036501">
        <property type="entry name" value="Inhibitor_vert_lysozyme_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89872">
        <property type="entry name" value="SSF89872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="9698" checksum="E35308B3FCF395DF" modified="2005-12-06" version="1">MFDADGYMDGPGGGVTPVTINGTVWLEGSSCKANACGWDYIVTLYNPKTHKVVGYYYNIDPGYLIWFGETGVHEFAYLVRDYVNKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HS0</accession>
    <name>Q32HS0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ymcD</name>
        <name evidence="3" type="ordered locus">SDY_0963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402626.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HS0"/>
    <dbReference type="EnsemblBacteria" id="ABB61135">
        <property type="protein sequence ID" value="ABB61135"/>
        <property type="gene ID" value="SDY_0963"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0963"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1111"/>
    <dbReference type="HOGENOM" id="CLU_166022_0_0_6"/>
    <dbReference type="OMA" id="GHDSNPG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221000" evidence="2">
        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="107" mass="10105" checksum="9D4B6E4D48B656DE" modified="2005-12-06" version="1">MNKGKVMKHKLSAILMAFMLTTPAAFAAPEAANGTEATTGTTGTTTTTTGATTTAATTGGVAAGAVGTATVVGVATAVGVATLAVVAANDSGDGGSHNTSTTTSTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HS2</accession>
    <name>Q32HS2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Caps_synth_GfcC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ymcB</name>
        <name evidence="3" type="ordered locus">SDY_0961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001038069.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402624.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HS2"/>
    <dbReference type="STRING" id="300267.SDY_0961"/>
    <dbReference type="EnsemblBacteria" id="ABB61133">
        <property type="protein sequence ID" value="ABB61133"/>
        <property type="gene ID" value="SDY_0961"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0961"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1109"/>
    <dbReference type="HOGENOM" id="CLU_080984_2_0_6"/>
    <dbReference type="OMA" id="TWWPGTA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010425">
        <property type="entry name" value="Caps_synth_GfcC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06251">
        <property type="entry name" value="Caps_synth_GfcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220846" description="Caps_synth_GfcC domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Caps_synth_GfcC" evidence="2">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="248" mass="27292" checksum="B4BD0BA2E9D840C3" modified="2005-12-06" version="1">MNKLQSYFIASVLYVMTPHAFAQGTVTIYLPGEQQTLSVGPVENVAQLVTQPQLRDRLWWPGALLTDSAVKAKALKDYQHVMAQLASWEAEADDDVAATIKSVRQQLLNLNITGRLPVKLDPDFVRVDENSNPPLVGDYTLYTVQRPVTITLLGAVSGAGQLPWQAGRSVTDYLQDHPRLAGADKNNVIVITPEGETVIAPVALWNKRHVEPPPGSQLWLGFSAHVLPEKYADLNDQIVSVLTQRVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HT5</accession>
    <name>Q32HT5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrogenase (acceptor)</fullName>
            <ecNumber evidence="6">1.12.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NiFe hydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">hyaA</name>
        <name evidence="19" type="ordered locus">SDY_0947</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>A + H2 = AH2</text>
            <dbReference type="Rhea" id="RHEA:12116"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:18276"/>
            <dbReference type="EC" id="1.12.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.12.99.6" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001058323.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402611.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HT5"/>
    <dbReference type="SMR" id="Q32HT5"/>
    <dbReference type="STRING" id="300267.SDY_0947"/>
    <dbReference type="EnsemblBacteria" id="ABB61120">
        <property type="protein sequence ID" value="ABB61120"/>
        <property type="gene ID" value="SDY_0947"/>
    </dbReference>
    <dbReference type="GeneID" id="66670752"/>
    <dbReference type="KEGG" id="sdy:SDY_0947"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1094"/>
    <dbReference type="HOGENOM" id="CLU_046107_0_0_6"/>
    <dbReference type="OMA" id="RSFNAHN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009375">
        <property type="term" value="C:ferredoxin hydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033748">
        <property type="term" value="F:hydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027394">
        <property type="entry name" value="Cytochrome-c3_hydrogenase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037148">
        <property type="entry name" value="NiFe-Hase_small_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001821">
        <property type="entry name" value="NiFe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30013">
        <property type="entry name" value="PTHR30013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14720">
        <property type="entry name" value="NiFe_hyd_SSU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000310">
        <property type="entry name" value="NiFe_hyd_ssu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00391">
        <property type="entry name" value="hydA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_q6" evidence="17">
        <location>
            <begin position="62"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="NiFe_hyd_SSU_C" evidence="18">
        <location>
            <begin position="227"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABB61120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="372" mass="40681" checksum="4AD3ECB4220D2826" modified="2005-12-06" version="1">MNNEETFYQAMRRQGVTRRSFLKYCSLAATSLGLGAGMAPKIAWALENKPRIPVVWIHGLECTCCTESFIRSAHPLAKDVILSLISLDYDDTLMAAAGTQAEEVFEDIITQYNGKYILAVEGNPPLGEQGMFCISSGRPFIEKLKRAAAGASAIIAWGTCASWGCVQAARPNPTQATPIDKVITDKPIIKVPGCPPIPDVMSAIITYMVTFDRLPDVDRMGRPLMFYGQRIHDKCYRRAHFDAGEFVQSWDDDAARKGYCLYKMGCKGPTTYNACSSTRWNDGVSFPIQSGHGCLGCAENGFWDRGSFYSRVVDIPQMGTHSTADTVGLTALGVVAAAVGVHAVASAVDQRRRHNQQPTETEHQPGNEDKQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-14" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HX1</accession>
    <name>EFPL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor P-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yeiP</name>
        <name type="ordered locus">SDY_0908</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB61084" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61084.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001136827.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402575.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HX1"/>
    <dbReference type="SMR" id="Q32HX1"/>
    <dbReference type="STRING" id="300267.SDY_0908"/>
    <dbReference type="EnsemblBacteria" id="ABB61084">
        <property type="protein sequence ID" value="ABB61084"/>
        <property type="gene ID" value="SDY_0908"/>
    </dbReference>
    <dbReference type="GeneID" id="66673932"/>
    <dbReference type="KEGG" id="sdy:SDY_0908"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1049"/>
    <dbReference type="HOGENOM" id="CLU_074944_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00646">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011897">
        <property type="entry name" value="Transl_elong_p-like_YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02178">
        <property type="entry name" value="yeiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000259901" description="Elongation factor P-like protein">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="190" mass="21533" checksum="628EF9E8A26EC7CA" modified="2006-11-14" version="2">MPRANEIKKGMVLNYNGKLLLVKDIDIQSPTARGAATLYKMRFSDVRTGLKVEERFKGDDIVDTVTLTRRYVDFSYVDGNEYVFMDKEDYTPYTFTKDQIEEELLFMPEGGMPDMQVLTWDGQLLALELPQTVDLEIVETAPGIKGASASARNKPATLSTGLVIQVPEYLSPGEKIRIHIEERRYMGRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HY8</accession>
    <name>Q32HY8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inner membrane protein YejM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yejM</name>
        <name evidence="6" type="ordered locus">SDY_0891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To H.influenzae HI_0842.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000256210.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402558.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HY8"/>
    <dbReference type="STRING" id="300267.SDY_0891"/>
    <dbReference type="EnsemblBacteria" id="ABB61067">
        <property type="protein sequence ID" value="ABB61067"/>
        <property type="gene ID" value="SDY_0891"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0891"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1031"/>
    <dbReference type="HOGENOM" id="CLU_030247_1_0_6"/>
    <dbReference type="OMA" id="QMLFSRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012159">
        <property type="entry name" value="YejM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024588">
        <property type="entry name" value="YejM_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11893">
        <property type="entry name" value="DUF3413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004950">
        <property type="entry name" value="Mmb_sulf_HI0842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3413" evidence="5">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="260"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="586" mass="67255" checksum="82E6211D6E68D422" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I02</accession>
    <name>Q32I02_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c-type protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">napC</name>
        <name evidence="14" type="ordered locus">SDY_0876</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="10">Binds 4 heme groups per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Binds 4 heme groups per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NapC/NirT/NrfH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000528365.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402544.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I02"/>
    <dbReference type="STRING" id="300267.SDY_0876"/>
    <dbReference type="EnsemblBacteria" id="ABB61053">
        <property type="protein sequence ID" value="ABB61053"/>
        <property type="gene ID" value="SDY_0876"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0876"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1011"/>
    <dbReference type="HOGENOM" id="CLU_096753_2_0_6"/>
    <dbReference type="OMA" id="FCTGCHE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019333">
        <property type="term" value="P:denitrification pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024717">
        <property type="entry name" value="NapC/NirT/NrfH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005126">
        <property type="entry name" value="NapC/NirT_cyt_c_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038266">
        <property type="entry name" value="NapC/NirT_cytc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011885">
        <property type="entry name" value="NO3Rdtase_cyt_c_NapC/NirT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03264">
        <property type="entry name" value="Cytochrom_NNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000013">
        <property type="entry name" value="4_hem_cytochrm_NapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02161">
        <property type="entry name" value="napC_nirT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_NNT" evidence="13">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>4</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000013-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000013-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB61053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="200" mass="23175" checksum="45BB6E25F9BAA872" modified="2005-12-06" version="1">MGNSDRKPDLIKRLWKWWRTPSRLALGTLLLIGFVGGIVFWGGFNTGMEKANTEEFCISCHEMRNTVYQEYMDSVHYNNRSGVRATCPDCHVPHEFVPKMIRKLKASKELYGKIFGVIDTPQKFEAHRLTMAQNEWRRMKDNNSQECRNCHNFEYMDTTAQKSVAAKMHDQAVKDGQTCIDCHKGIAHKLPDMREVELGF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I45</accession>
    <name>BIOF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">8-amino-7-oxononanoate synthase</fullName>
            <shortName evidence="1">AONS</shortName>
            <ecNumber evidence="1">2.3.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-keto-8-amino-pelargonic acid synthase</fullName>
            <shortName evidence="1">7-KAP synthase</shortName>
            <shortName evidence="1">KAPA synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">8-amino-7-ketopelargonate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bioF</name>
        <name type="ordered locus">SDY_0830</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000118818.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402501.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I45"/>
    <dbReference type="SMR" id="Q32I45"/>
    <dbReference type="STRING" id="300267.SDY_0830"/>
    <dbReference type="EnsemblBacteria" id="ABB61012">
        <property type="protein sequence ID" value="ABB61012"/>
        <property type="gene ID" value="SDY_0830"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0830"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.956"/>
    <dbReference type="HOGENOM" id="CLU_015846_11_2_6"/>
    <dbReference type="OMA" id="HYHASGI"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01693">
        <property type="entry name" value="BioF_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004723">
        <property type="entry name" value="AONS_Archaea/Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022834">
        <property type="entry name" value="AONS_Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00858">
        <property type="entry name" value="bioF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0093">Biotin biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000381110" description="8-amino-7-oxononanoate synthase">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01693"/>
        </source>
    </evidence>
    <sequence length="384" mass="41576" checksum="03710A7504083976" modified="2005-12-06" version="1">MSWQEKINAALDARRAADALRRRYPVAQGAGRWLVADDRQYLNFSSNDYLGLSHHPQIIRAWKQGAEQFGVGSGGSGHVSGYSVAHQALEEELAEWLGYSRALLFISGFAANQAVIAAMMAKEDRIVADRLSHASLLEAASLSPSQLRRFVHNDVTHLARLLASPCPGQQLVVTEGVFSMDGDSAPLGEIQQVTQQHNGWLMVDDAHGTGVIGEQGRGSCWLQKVKPELLVVTFGKGFGVSGAAVLCSSTVADYLLQFARHLIYSTSMPPAQAQALRASLAVIRSDEGDARREKLAALITRFRAGVQDLPFTLADSCSAIQPLIVGDNSRALQLAEKLRQQGCWVTAIRPPTVPAGTARLRLTLTAAHEMQDIDRLLEVLHGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I64</accession>
    <name>Q32I64_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybhR</name>
        <name evidence="7" type="ordered locus">SDY_0811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000469022.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402482.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I64"/>
    <dbReference type="STRING" id="300267.SDY_0811"/>
    <dbReference type="EnsemblBacteria" id="ABB60993">
        <property type="protein sequence ID" value="ABB60993"/>
        <property type="gene ID" value="SDY_0811"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0811"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.935"/>
    <dbReference type="HOGENOM" id="CLU_039483_8_3_6"/>
    <dbReference type="OMA" id="AHARYNP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="368" mass="41552" checksum="D51F56634BD88953" modified="2005-12-06" version="1">MFHRLWTLIRKELQSLLREPQTRAILILPVLIQVILFPFAATLEVTNATIAIYDEDNGEHSVELAQRFARASAFTHVLLLKSPQEIRPTIDTQKALLLVRFPADFSRKLDTYQTAPLQLILDGRNSNSAQIAANYLQQIVKNYQQELLEGKPKPNNSELVVRNWYNPNLDYKWFVVPSLIAMITTIGVMIVTSLSVAREREQGTLDQLLVSPLTTWQIFIGKAVPALIVATFQATIVLAIGIWAYQIPFAGSLALFYFTMVIYGLSLVGFGLLISSLCSTQQQAFIGVFVFMMPAILLSGYVSPVENMPVWLQNLTWINPIRHFTDITKQIYLKDASLDIVWNSLWPLLVITATTGSAAYAMFRRKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I88</accession>
    <name>Q32I88_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamine high-affinity transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glnP</name>
        <name evidence="11" type="ordered locus">SDY_0786</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001159065.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402458.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I88"/>
    <dbReference type="SMR" id="Q32I88"/>
    <dbReference type="STRING" id="300267.SDY_0786"/>
    <dbReference type="EnsemblBacteria" id="ABB60969">
        <property type="protein sequence ID" value="ABB60969"/>
        <property type="gene ID" value="SDY_0786"/>
    </dbReference>
    <dbReference type="GeneID" id="66670918"/>
    <dbReference type="KEGG" id="sdy:SDY_0786"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.906"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_0_6"/>
    <dbReference type="OMA" id="IGLHYST"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="24364" checksum="20A94A31BE02121C" modified="2005-12-06" version="1">MQFDWSAIWPAIPLLIEGAKMTLWISVLGLAGGLVIGLLAGFARTFGGWIANHVALVFIEVIRGTPIVVQVMFIYFALPMAFNDLRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRWETIRYVILPLALRRMLPPLGNQWIISIKDTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVFYLIITLVLSFILRRLERRMKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I94</accession>
    <name>Q32I94_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulator MntR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Manganese transport regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_0779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000091024.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402452.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I94"/>
    <dbReference type="STRING" id="300267.SDY_0779"/>
    <dbReference type="EnsemblBacteria" id="ABB60963">
        <property type="protein sequence ID" value="ABB60963"/>
        <property type="gene ID" value="SDY_0779"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0779"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.897"/>
    <dbReference type="HOGENOM" id="CLU_069532_2_0_6"/>
    <dbReference type="OMA" id="SWDAIDR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="155" mass="17655" checksum="C6944BF5FC0BD490" modified="2005-12-06" version="1">MSRRAGTPTAKKVTQLVNVEKHVEGFRQVREAHRRELIDDYVELISDLIREVGEARQVDMAARLGVSQPTVAKMLKRLATMGLIEMIPWRGVFLTAEGEKLAQESRERHQIVENFLLVLGVSPEIARRDSEGMEHHVSEETLDAFRLFTQKHGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IL6</accession>
    <name>Q32IL6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ybgP</name>
        <name evidence="9" type="ordered locus">SDY_0652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the periplasmic pilus chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402330.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IL6"/>
    <dbReference type="STRING" id="300267.SDY_0652"/>
    <dbReference type="EnsemblBacteria" id="ABB60841">
        <property type="protein sequence ID" value="ABB60841"/>
        <property type="gene ID" value="SDY_0652"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0652"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.760"/>
    <dbReference type="HOGENOM" id="CLU_070768_5_1_6"/>
    <dbReference type="OMA" id="AQVWLEN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036316">
        <property type="entry name" value="Pili_assmbl_chap_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001829">
        <property type="entry name" value="Pili_assmbl_chaperone_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016148">
        <property type="entry name" value="Pili_assmbl_chaperone_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018046">
        <property type="entry name" value="Pili_assmbl_chaperone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016147">
        <property type="entry name" value="Pili_assmbl_chaperone_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02753">
        <property type="entry name" value="PapD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00345">
        <property type="entry name" value="PapD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00969">
        <property type="entry name" value="CHAPERONPILI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="SSF49354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49584">
        <property type="entry name" value="SSF49584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00635">
        <property type="entry name" value="PILI_CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PapD_N" evidence="7">
        <location>
            <begin position="31"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_C" evidence="8">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="231" mass="26154" checksum="E9897E100F83A1A9" modified="2005-12-06" version="1">MAFRVLTMAVDLCRLTTRTMNVNAGHERTSKSRIIHQIQLIRGITENEKGEKSDEFLVALPPIQRLEPKATSQVRIMKQAATAKVPTDRESLFYYNLREIPPVPEGSEGHAILQVAVQSRIKLFWRPAALRKKMGDHVEQQLQVSQQNNQLTLKNPTGYYLTIAYLGRDEKGVLPGFKSTMVAPFSSVTTSTGSYSGKQFYLGYMDDYGALRMNTLSCQRQCRLQPVENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IM1</accession>
    <name>Q32IM1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybgK</name>
        <name evidence="5" type="ordered locus">SDY_0647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000912729.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402325.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IM1"/>
    <dbReference type="STRING" id="300267.SDY_0647"/>
    <dbReference type="EnsemblBacteria" id="ABB60836">
        <property type="protein sequence ID" value="ABB60836"/>
        <property type="gene ID" value="SDY_0647"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0647"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.755"/>
    <dbReference type="HOGENOM" id="CLU_028967_0_3_6"/>
    <dbReference type="OMA" id="QDLGRSH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="310" mass="34458" checksum="98DD87A1681F61FE" modified="2005-12-06" version="1">MLKIIRAGMYTTVQDGGRHGFRQSGISHCGALDMPALRIANLLVGNDANAPALEITLGQLTVEFETDGWFALTGAGCEARLDDNAVWTGWRLPMKAGQRLTLKRPQHGMRSYLAVAGGIDVPPVMGSCSTDLKVGIGGLEGRLLRDGDRLPIGKAKCDFMEAQGVKQLLWGNRIRALPGPEYHEFDRASQDAFWRSPWQLSPQSNRMGYRLQGQILKRTTERELLSHGLLPGVVQVPHNGQPIVLMNDAQTTGGYPRIACIIEADMYHLAQIPLGQPIHFVQCSLEEALKARQDQQRYFEQLVWRLHNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IQ8</accession>
    <name>Q32IQ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IQ8"/>
    <dbReference type="EnsemblBacteria" id="ABB60799">
        <property type="protein sequence ID" value="ABB60799"/>
        <property type="gene ID" value="SDY_0601"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0601"/>
    <dbReference type="HOGENOM" id="CLU_3116952_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="45" mass="4960" checksum="2287AE64250A6F98" modified="2005-12-06" version="1">MMCSNQLSYVARLFLRWLGYLDSNQGMPVSKTGALPLGDTPITGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IR7</accession>
    <name>Q32IR7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402279.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IR7"/>
    <dbReference type="EnsemblBacteria" id="ABB60790">
        <property type="protein sequence ID" value="ABB60790"/>
        <property type="gene ID" value="SDY_0591"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0591"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.693"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="IFRFIME"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="270" mass="31189" checksum="36D9A6F90957832F" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQSGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSPTRKAIIQAQIDKAIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IS1</accession>
    <name>Q32IS1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS911 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402275.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IS1"/>
    <dbReference type="STRING" id="300267.SDY_0586"/>
    <dbReference type="EnsemblBacteria" id="ABB60786">
        <property type="protein sequence ID" value="ABB60786"/>
        <property type="gene ID" value="SDY_0586"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0586"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.686"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_9_6"/>
    <dbReference type="OMA" id="YSHSEAA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13608" checksum="403B7DA307BF1C74" modified="2005-12-06" version="1">MSVKLRLPQCSPQNNTGAPMKKRNFSTEFKRESTQLVVDQNYTVADAAKAMDVGLSTMTRWVKQLRDERQGKTPKASPITPEQIEIRELRKKLQRIEMENEILKKATALLMSDSLNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IZ1</accession>
    <name>Q32IZ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IZ1"/>
    <dbReference type="EnsemblBacteria" id="ABB60716">
        <property type="protein sequence ID" value="ABB60716"/>
        <property type="gene ID" value="SDY_0509"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0509"/>
    <dbReference type="HOGENOM" id="CLU_052819_6_2_6"/>
    <dbReference type="OMA" id="RVYRIMC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="9013" checksum="A95246ED4028279F" modified="2005-12-06" version="1">MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGLSSGMGAASQTGRT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J23</accession>
    <name>CRL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sigma factor-binding protein Crl</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crl</name>
        <name type="ordered locus">SDY_0477</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Crl family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000174704.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402173.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J23"/>
    <dbReference type="SMR" id="Q32J23"/>
    <dbReference type="STRING" id="300267.SDY_0477"/>
    <dbReference type="EnsemblBacteria" id="ABB60684">
        <property type="protein sequence ID" value="ABB60684"/>
        <property type="gene ID" value="SDY_0477"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0477"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.562"/>
    <dbReference type="HOGENOM" id="CLU_136773_0_0_6"/>
    <dbReference type="OMA" id="FWGWWLE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01178">
        <property type="entry name" value="Crl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009986">
        <property type="entry name" value="Tscrpt_reg_Crl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038208">
        <property type="entry name" value="Tscrpt_reg_Crl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07417">
        <property type="entry name" value="Crl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000268906" description="Sigma factor-binding protein Crl">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Essential for activity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01178"/>
        </source>
    </evidence>
    <sequence length="133" mass="15682" checksum="FDB6CC435DFEEDCC" modified="2007-01-23" version="3">MTLPSGYPKSRLIKKFTALGPYIREGKCEDNRFFFDCLAVCVNVKPAPEVREFWGWWMELEAQESRFTYSYQFGLFDKAGDWKSVPVKDTEVVERLEHTLREFHEKLRELLTTLNLKLEPADDFRDEPVKLTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J27</accession>
    <name>PROA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="1">GPR</shortName>
            <ecNumber evidence="1">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proA</name>
        <name type="ordered locus">SDY_0473</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000893250.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402169.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J27"/>
    <dbReference type="SMR" id="Q32J27"/>
    <dbReference type="STRING" id="300267.SDY_0473"/>
    <dbReference type="EnsemblBacteria" id="ABB60680">
        <property type="protein sequence ID" value="ABB60680"/>
        <property type="gene ID" value="SDY_0473"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0473"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.558"/>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_6"/>
    <dbReference type="OMA" id="PGVCNAM"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000230023" description="Gamma-glutamyl phosphate reductase">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <sequence length="417" mass="44602" checksum="DFB2F4916FF862A1" modified="2005-12-06" version="1">MLEQMGIAAKQASYKLAQLSSREKNRVLEKIADELEAQSEIILNANAQDVADARANGLGEAMLDRLALTPARLKGIADDVRQVCNLADPVGQVIDGGILDSGLRLERRRVPLGVIGVIYEARPNVTVDVASLCLKTGNAVILRGGKETCRTNAATVAVIQDALNSCGLPAGAVQAIDNPDRALVSEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIYVDESAEIAEALKVIVNAKTQRPSTCNTVETLLVNKNIADSFLPALSKQMAESGVTLHADAAALAQLQTGPAKVVAVKAEEYDDEFLSLDLNVKIVSDLDDAIAHIREHGTQHSDAILTRDMRNAQRFVNEVDSSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGIGDYTIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JL8</accession>
    <name>Q32JL8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ylbE</name>
        <name evidence="1" type="ordered locus">SDY_0269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JL8"/>
    <dbReference type="STRING" id="300267.SDY_0269"/>
    <dbReference type="EnsemblBacteria" id="ABB60489">
        <property type="protein sequence ID" value="ABB60489"/>
        <property type="gene ID" value="SDY_0269"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0269"/>
    <dbReference type="HOGENOM" id="CLU_036192_0_0_6"/>
    <dbReference type="OMA" id="TGDRWFT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009499">
        <property type="entry name" value="DUF1116"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06545">
        <property type="entry name" value="DUF1116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="333" mass="35638" checksum="D37C2625FC084AB4" modified="2005-12-06" version="1">MNFIPCHHVNAVGPMGGITSASMPMLVVENVTDGNRAYCNLNEGIGKVMRFGAYGEDVLTRHRWMRDVLMPVLSAALGRMERGIDLTAMMAQGITMGDEFHQRNIASSALLMRALAPQIARLDHDKQHIAEVMDFLSVTDQFFLNLAMAYCKAAMDAGAMIRAGSIVTAMTRNGNMFGIRVSGLGERWFTAPVNTPQGLFFTGFSQEQANPDMGDSAITETFGIGGAAMIAALGVTRFVGAGGMEAARAVSEEMAEIFLERNMQLQIPGWDFQGACLGLDIRRVVETGITPLINTGIAHKEAGIGQIGAGTVRAPLACFEQALEALAESMGIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K57</accession>
    <name>CAIT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-carnitine/gamma-butyrobetaine antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">caiT</name>
        <name type="ordered locus">SDY_0062</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the exchange of L-carnitine for gamma-butyrobetaine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)</text>
            <dbReference type="Rhea" id="RHEA:29427"/>
            <dbReference type="ChEBI" id="CHEBI:16244"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine metabolism; carnitine metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000787133.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401789.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K57"/>
    <dbReference type="SMR" id="Q32K57"/>
    <dbReference type="STRING" id="300267.SDY_0062"/>
    <dbReference type="EnsemblBacteria" id="ABB60300">
        <property type="protein sequence ID" value="ABB60300"/>
        <property type="gene ID" value="SDY_0062"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0062"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.68"/>
    <dbReference type="HOGENOM" id="CLU_010118_6_0_6"/>
    <dbReference type="OMA" id="AWAPFTG"/>
    <dbReference type="UniPathway" id="UPA00117"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044667">
        <property type="term" value="F:(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900751">
        <property type="term" value="P:4-(trimethylammonio)butanoate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01049">
        <property type="entry name" value="CaiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023449">
        <property type="entry name" value="BCCT_transptr_CaiT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000064335" description="L-carnitine/gamma-butyrobetaine antiporter">
        <location>
            <begin position="1"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01049"/>
        </source>
    </evidence>
    <sequence length="504" mass="56432" checksum="3453EC8384857668" modified="2005-12-06" version="1">MKNEKRKTGMEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMEVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWIILNAICVACGLQKGGRIASDVPSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDPIAKGGFPQGWSVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVLGLTASTWILWTVLGSNTLLLIDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATVTLVNACSYTLAMSTCREVRGGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGGCPLFFVNIMVTLSFIKDAKQNWKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K71</accession>
    <name>SYI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="1">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ileS</name>
        <name type="ordered locus">SDY_0048</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001286837.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401775.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K71"/>
    <dbReference type="SMR" id="Q32K71"/>
    <dbReference type="STRING" id="300267.SDY_0048"/>
    <dbReference type="EnsemblBacteria" id="ABB60286">
        <property type="protein sequence ID" value="ABB60286"/>
        <property type="gene ID" value="SDY_0048"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0048"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.52"/>
    <dbReference type="HOGENOM" id="CLU_001493_7_1_6"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000022125" description="Isoleucine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="602"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>L-isoleucyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:178002"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="901"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="904"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="921"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="924"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02002"/>
        </source>
    </evidence>
    <sequence length="938" mass="104325" checksum="96B83D128CCE7644" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q326S1</accession>
    <name>Q326S1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MxiG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mxiG</name>
        <name evidence="2" type="ordered locus">SDY_P174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001287355.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406175.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326S1"/>
    <dbReference type="EnsemblBacteria" id="ABB64687">
        <property type="protein sequence ID" value="ABB64687"/>
        <property type="gene ID" value="SDY_P174"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P174"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5731"/>
    <dbReference type="HOGENOM" id="CLU_745759_0_0_6"/>
    <dbReference type="OMA" id="HIQFSIS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019029">
        <property type="entry name" value="T3SS_PrgH/EprH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09480">
        <property type="entry name" value="PrgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="371" mass="42964" checksum="DFCF9B5BF3058A68" modified="2005-12-06" version="1">MSEAKNSNLAPFRLLVKLTNGVGDEFPLYYGNNLIVLGRTIETLEFGNDNFPENIIPVTDSKSDGIIYLTISKDNICQFSDEKGEQIDINSQFNSFEYDGISFHLKNMREDKSRGHILNGMYKNPSVFFFFAVIVVLIIIFSLSLKKDEVKEIAEIIDDNRYGIVNTGQCNYILAETQNDAVWASVALNKTGFTKCRYILVSNKEINRIQQYINQRFPYINLYVLNLVSDKAELLVFLSKERNSSKDTELDKLKNALIVEFPYIKNIKFNYLSDHNARGDAKGIFTKVNVQYKEICENNKVTYSVREELTDEKLELINRLISEHKNIYGDQYIEFSVLLIDDDFKGKSYLNSKDSYVMLNDKHWFFLDKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q326U1</accession>
    <name>Q326U1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS1353 orf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406155.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326U1"/>
    <dbReference type="EnsemblBacteria" id="ABB64667">
        <property type="protein sequence ID" value="ABB64667"/>
        <property type="gene ID" value="SDY_P154"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P154"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5710"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_10_6"/>
    <dbReference type="OMA" id="ELNDRDY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="1">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="80" mass="9489" checksum="9F5ACAEC15BDCA1E" modified="2005-12-06" version="1">MLTDIFNSNYQCYGYRRLHAMLRHEGGRLSEKVVRRLMVEEQLVVSRNRRRRYSSYCGEIGPAPDNLIARDFKAEQPNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q326V0</accession>
    <name>Q326V0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406146.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326V0"/>
    <dbReference type="EnsemblBacteria" id="ABB64658">
        <property type="protein sequence ID" value="ABB64658"/>
        <property type="gene ID" value="SDY_P145"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P145"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5702"/>
    <dbReference type="HOGENOM" id="CLU_152494_1_1_6"/>
    <dbReference type="OMA" id="DTEKFHE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014795">
        <property type="entry name" value="Vibrio_phage_ICP1_Orf50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35401">
        <property type="entry name" value="PTHR35401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08681">
        <property type="entry name" value="DUF1778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="96" mass="11183" checksum="428C53E69E50BFA8" modified="2005-12-06" version="1">MSTAASVRKTPREHQINIRATDEERAVIDYAASLVNKNRTDFIMELAYQEAKNIILDQRLFVLDNERYDSFITQLEAPVQNAEGRERLMAVKPEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q326W7</accession>
    <name>Q326W7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_P128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406129.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326W7"/>
    <dbReference type="EnsemblBacteria" id="ABB64641">
        <property type="protein sequence ID" value="ABB64641"/>
        <property type="gene ID" value="SDY_P128"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P128"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5682"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="9694" checksum="F4FE9080266F6CFD" modified="2005-12-06" version="1">MSLLLPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKALSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q326X4</accession>
    <name>Q326X4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OriT nicking and unwinding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011379018.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406122.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326X4"/>
    <dbReference type="EnsemblBacteria" id="ABB64634">
        <property type="protein sequence ID" value="ABB64634"/>
        <property type="gene ID" value="SDY_P121"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P121"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5676"/>
    <dbReference type="HOGENOM" id="CLU_1921466_0_0_6"/>
    <dbReference type="OMA" id="ISMMAML"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014059">
        <property type="entry name" value="Conjug_relaxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02686">
        <property type="entry name" value="relax_trwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="2">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="139" mass="14990" checksum="3B3B836A21077AAA" modified="2005-12-06" version="1">MMSIAQVRSAGSAGNYYTDKDNYYVLGSMGERWAGQGAEQLGLQGSVDKDVFTRLLEGRLPDGADLSRMQDGSNKHRPGYDLTFSAPKSVSMMAMLGGDKRLIDAHNQAVDFAVRHHPCGGTGLHTGDDGRTVRNGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q327C3</accession>
    <name>Q327C3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISSfl1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P042</name>
        <name evidence="2" type="ordered locus">SDY_P072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
            <plasmid evidence="2">pSD1_197</plasmid>
            <plasmid evidence="2">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406043.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406073.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64555">
        <property type="protein sequence ID" value="ABB64555"/>
        <property type="gene ID" value="SDY_P042"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64585">
        <property type="protein sequence ID" value="ABB64585"/>
        <property type="gene ID" value="SDY_P072"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P042"/>
    <dbReference type="KEGG" id="sdy:SDY_P072"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5587"/>
    <dbReference type="HOGENOM" id="CLU_055261_2_2_6"/>
    <dbReference type="OMA" id="RYGPWAT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="149" mass="16716" checksum="1DAF2F75C86CD052" modified="2005-12-06" version="1">MARYDLPDEAWTIIKPLLPPEPATPRAGRPWAEHRKIINGMFWVLCSGAPWRDLPERYGAWKTVYNRFNRWSKSGVINIIFNRLLSLLDANGFIDWSATALDGSNIRALKCAAGAQKNIPISTEIMGRVALAAVLAPKSIWQQTEVASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q327R5</accession>
    <name>Q327R5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327R5"/>
    <dbReference type="EnsemblBacteria" id="ABB64440">
        <property type="protein sequence ID" value="ABB64440"/>
        <property type="gene ID" value="SDY_4577"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4577"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="85" mass="9439" checksum="BFF9D6A9F5109BA5" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITGNRIQCTSDQKHSSDKSGRNAKNIGIKEHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q327X0</accession>
    <name>Q327X0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjbR</name>
        <name evidence="1" type="ordered locus">SDY_4510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000155657.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405876.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327X0"/>
    <dbReference type="SMR" id="Q327X0"/>
    <dbReference type="STRING" id="300267.SDY_4510"/>
    <dbReference type="EnsemblBacteria" id="ABB64385">
        <property type="protein sequence ID" value="ABB64385"/>
        <property type="gene ID" value="SDY_4510"/>
    </dbReference>
    <dbReference type="GeneID" id="66672027"/>
    <dbReference type="KEGG" id="sdy:SDY_4510"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5331"/>
    <dbReference type="HOGENOM" id="CLU_105851_1_2_6"/>
    <dbReference type="OMA" id="KVFAWIF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="118" mass="13519" checksum="EE62FB333CED568B" modified="2005-12-06" version="1">MTISELLQYCMAKPGAEQSVHNDWKATQIKVEDVLFAMVKEVENRPAVSLKTSPELAELLRQQHSDVRPSRHLNKAHWSTVYLDGSLPDSQIYYLVDASYQQAVNLLPEEKRKLLVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Y0</accession>
    <name>Q327Y0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_4500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405866.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Y0"/>
    <dbReference type="EnsemblBacteria" id="ABB64375">
        <property type="protein sequence ID" value="ABB64375"/>
        <property type="gene ID" value="SDY_4500"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4500"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5315"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14960" checksum="F078BDBD71A88B56" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDSWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q328F2</accession>
    <name>Q328F2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">hflX</name>
        <name evidence="10" type="ordered locus">SDY_4416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000460358.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405794.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328F2"/>
    <dbReference type="STRING" id="300267.SDY_4416"/>
    <dbReference type="EnsemblBacteria" id="ABB64303">
        <property type="protein sequence ID" value="ABB64303"/>
        <property type="gene ID" value="SDY_4416"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4416"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5214"/>
    <dbReference type="HOGENOM" id="CLU_019597_2_1_6"/>
    <dbReference type="OMA" id="AEMKTGR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045498">
        <property type="entry name" value="HflX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19275">
        <property type="entry name" value="HflX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="198"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="343"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="426" mass="48273" checksum="8B384798F2FEE33A" modified="2005-12-06" version="1">MFDRYDAGEQAVLVHIYFTQDKDMEDLQEFESLVSSAGVEALQVITGSRKAPHPKYFVGEGKAVEIAEAVKATGASVVLFDHALSPAQERNLERLCECRVIDRTGLILDIFAQRARTHEGKLQVELAQLRHLATRLVRGWTHLERQKGGIGLRGPGETQLETDRRLLRNRIVQIQSRLERVEKQREQGRQSRIKADVPTVSLVGYTNAGKSTLFNRITEARVYAADQLFATLDPTLRRIDVADVGETVLADTVGFIRHLPHDLVAAFKATLQETRQATLLLHVIDAADVRVQENIEAVNTVLEEIDAHEIPTLLVMNKIDMLEDFEPCIDRDEENKPIRVWLSAQTGAGIPQLFQALTERLSGEVAQHTLRLPPQEGRLRSRFYQLQAIEKEWMEEDGSVSLQVRMPIVDWRRLCKQEPALIDYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q328H1</accession>
    <name>Q328H1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="3 11">1.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">frdB</name>
        <name evidence="14" type="ordered locus">SDY_4397</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a menaquinone + succinate = a menaquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:27834"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="11">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="11">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="3 11"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000829501.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405775.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328H1"/>
    <dbReference type="STRING" id="300267.SDY_4397"/>
    <dbReference type="EnsemblBacteria" id="ABB64284">
        <property type="protein sequence ID" value="ABB64284"/>
        <property type="gene ID" value="SDY_4397"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4397"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5193"/>
    <dbReference type="HOGENOM" id="CLU_044838_3_2_6"/>
    <dbReference type="OMA" id="AFASDCR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 11" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB64284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="244" mass="27126" checksum="26A718B993D29ADC" modified="2005-12-06" version="1">MAEMKNLKIEVVRYNPEVDTAPHSAFYEVPYDATTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNNVPKLACKTFLRDYTDGMKVEALANFPIERDLVVDMTHFIESLEAIKPYIIGNSRTSDQGTNIQTPAQMAKYHQFSGCINCGLCYAACPQFGLTPEFIGPAAITLAHRYNEDSRDHGKKERMAQLNSQNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESSKDFLIATLKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q328J2</accession>
    <name>Q328J2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ytfB</name>
        <name evidence="4" type="ordered locus">SDY_4376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405754.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328J2"/>
    <dbReference type="STRING" id="300267.SDY_4376"/>
    <dbReference type="EnsemblBacteria" id="ABB64263">
        <property type="protein sequence ID" value="ABB64263"/>
        <property type="gene ID" value="SDY_4376"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4376"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5168"/>
    <dbReference type="HOGENOM" id="CLU_065360_1_0_6"/>
    <dbReference type="OMA" id="QQWRTYR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013731">
        <property type="entry name" value="OapA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007340">
        <property type="entry name" value="Opacity-associatedA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04225">
        <property type="entry name" value="OapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08525">
        <property type="entry name" value="OapA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OapA_N" evidence="3">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="OapA" evidence="2">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="224" mass="24939" checksum="4F6DB6BE786E1801" modified="2005-12-06" version="1">MIEEQDAEQEETMPGRFELKPTLEKVWHAPDNFRFMDPLPPMHRRGIIIAAIVLVVGFLLPSDDTPNAPVVTREAQLDIQSQSQPPTEEQLRAQLVTPQNDPDQVAPVAPEPIQEGQPEEQPQTTQTQPFQPDSGIDNQWRSYRVEPGKTMAQLFRDHGLPATDVYAMAQVEGAGKPLSNLQNGQMVKIRQNASGVVTGLTIDTGNNQQVLFTRQPDGSFIRAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q328K3</accession>
    <name>ULAB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ascorbate-specific PTS system EIIB component</fullName>
            <ecNumber evidence="2">2.7.1.194</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ascorbate-specific phosphotransferase enzyme IIB component</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ulaB</name>
        <name type="ordered locus">SDY_4363</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] = L-ascorbate 6-phosphate(in) + L-histidyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:42436"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:61698"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.1.194"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Induced by L-ascorbate. Repressed by UlaR.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.194" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000218365.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405743.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328K3"/>
    <dbReference type="SMR" id="Q328K3"/>
    <dbReference type="STRING" id="300267.SDY_4363"/>
    <dbReference type="EnsemblBacteria" id="ABB64252">
        <property type="protein sequence ID" value="ABB64252"/>
        <property type="gene ID" value="SDY_4363"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4363"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5151"/>
    <dbReference type="HOGENOM" id="CLU_159248_0_0_6"/>
    <dbReference type="OMA" id="QSKGMTN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0598">Phosphotransferase system</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000230328" description="Ascorbate-specific PTS system EIIB component">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="1 4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine" evidence="1 4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P69822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="101" mass="10913" checksum="84CAF3A89050D47D" modified="2005-12-06" version="1">MTVRILAVCGNGQGSSMIMKMKVDQFLTQSNIDHTVNSCAVGEYKSELSGADIIIASTHMAGEITVTGNKYVVGVRNMLSPADFGPKLLKVIKEHFPQDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q328S2</accession>
    <name>Q328S2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, chi subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">holC</name>
        <name evidence="1" type="ordered locus">SDY_4283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000786399.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405674.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328S2"/>
    <dbReference type="SMR" id="Q328S2"/>
    <dbReference type="STRING" id="300267.SDY_4283"/>
    <dbReference type="EnsemblBacteria" id="ABB64183">
        <property type="protein sequence ID" value="ABB64183"/>
        <property type="gene ID" value="SDY_4283"/>
    </dbReference>
    <dbReference type="GeneID" id="67414878"/>
    <dbReference type="KEGG" id="sdy:SDY_4283"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5049"/>
    <dbReference type="HOGENOM" id="CLU_131584_0_0_6"/>
    <dbReference type="OMA" id="WQFEPSA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007459">
        <property type="entry name" value="DNA_pol3_chi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036768">
        <property type="entry name" value="PolIII_chi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38767">
        <property type="entry name" value="PTHR38767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04364">
        <property type="entry name" value="DNA_pol3_chi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102400">
        <property type="entry name" value="SSF102400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="147" mass="16574" checksum="ADEFFE379B28AA8B" modified="2005-12-06" version="1">MKNATFYLLDNDTTVDGLSAVEQLVCEIAAERWRSGKRVLIACEDEKQAYRLDEALWARPAESFVPHNLAGEGPRGGAPVEIAWPQKRSSSPRDILISLRTSFADFATAFTEVVDFVPYEDSLKQLARERYKAYRVAGFNLNTATWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q328T9</accession>
    <name>Q328T9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">pyr operon leader peptide</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">pyrBI operon attenuator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrL</name>
        <name evidence="5" type="ordered locus">SDY_4265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001296693.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405657.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328T9"/>
    <dbReference type="EnsemblBacteria" id="ABB64166">
        <property type="protein sequence ID" value="ABB64166"/>
        <property type="gene ID" value="SDY_4265"/>
    </dbReference>
    <dbReference type="GeneID" id="67414871"/>
    <dbReference type="KEGG" id="sdy:SDY_4265"/>
    <dbReference type="HOGENOM" id="CLU_213745_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012602">
        <property type="entry name" value="PyrBI_leader"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08052">
        <property type="entry name" value="PyrBI_leader"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003249">
        <property type="entry name" value="PyrBI_leader"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0428">Leader peptide</keyword>
    <keyword evidence="4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="44" mass="5098" checksum="57963426EC457005" modified="2005-12-06" version="1">MVQCVRHFVLPRLKKDAGLPFFFPLITHSQPLNRGAFFCPGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q329H1</accession>
    <name>Q329H1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphonate metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phnP</name>
        <name evidence="2" type="ordered locus">SDY_4124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000059931.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405525.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329H1"/>
    <dbReference type="STRING" id="300267.SDY_4124"/>
    <dbReference type="EnsemblBacteria" id="ABB64034">
        <property type="protein sequence ID" value="ABB64034"/>
        <property type="gene ID" value="SDY_4124"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4124"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4848"/>
    <dbReference type="HOGENOM" id="CLU_044538_3_0_6"/>
    <dbReference type="OMA" id="HIHFDHL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07736">
        <property type="entry name" value="PhnP-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035682">
        <property type="entry name" value="PhnP_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017693">
        <property type="entry name" value="Phosphonate_metab_PhnP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03307">
        <property type="entry name" value="PhnP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="68"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="252" mass="28002" checksum="0F081CEB1D62FB82" modified="2005-12-06" version="1">MSLTLTLTGTGGAQGVPAWGCECAACARARRSPQYRRQPCSGVVKFNEAITLIDAGLHDLTDRWSLGSFQQFLLTHYHMDHVQELFPLRWGVGDPIPVYGPPDEQGCDDLFKHPGLLDFSHTVEPFVVFDLQGLQVTPLPLNHSKLTFGYLLETAHSRVAWLSDTVGLPEKTLKFLRNNQPQVMVIDCSHPPREDAPRNHCDLNTVLALNQVIRSPRVILTHISHQFDAWLMENALPSGFEAGFDGIEIGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q329I4</accession>
    <name>Q329I4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phnA</name>
        <name evidence="4" type="ordered locus">SDY_4109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YjdM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001300891.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405512.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329I4"/>
    <dbReference type="SMR" id="Q329I4"/>
    <dbReference type="STRING" id="300267.SDY_4109"/>
    <dbReference type="EnsemblBacteria" id="ABB64021">
        <property type="protein sequence ID" value="ABB64021"/>
        <property type="gene ID" value="SDY_4109"/>
    </dbReference>
    <dbReference type="GeneID" id="67414732"/>
    <dbReference type="KEGG" id="sdy:SDY_4109"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4833"/>
    <dbReference type="HOGENOM" id="CLU_134486_0_1_6"/>
    <dbReference type="OMA" id="SCLYEWN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004624">
        <property type="entry name" value="YjdM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013988">
        <property type="entry name" value="YjdM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013987">
        <property type="entry name" value="YjdM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF3">
        <property type="entry name" value="PTHR30305:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03831">
        <property type="entry name" value="YjdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08274">
        <property type="entry name" value="YjdM_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00686">
        <property type="entry name" value="phnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjdM_Zn_Ribbon" evidence="3">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="YjdM" evidence="2">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="111" mass="12345" checksum="52FD9C7B197F17E4" modified="2005-12-06" version="1">MSLPHCPKCNSEYTYEDNGMYICPECAYEWNDAEPAQESDELIVKDANGNLLADGDSVTIIKDLKVKGSSSMLKIGTKVKNIRLVEGDHNIDCKIDGFGPMKLKSEFVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q329K4</accession>
    <name>Q329K4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">recG</name>
        <name evidence="9" type="ordered locus">SDY_4084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000678413.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405492.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329K4"/>
    <dbReference type="STRING" id="300267.SDY_4084"/>
    <dbReference type="EnsemblBacteria" id="ABB64001">
        <property type="protein sequence ID" value="ABB64001"/>
        <property type="gene ID" value="SDY_4084"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4084"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4805"/>
    <dbReference type="HOGENOM" id="CLU_005122_7_1_6"/>
    <dbReference type="OMA" id="DNGFQAC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="283"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="482"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="693" mass="76530" checksum="98E985958FE6AED7" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q329N4</accession>
    <name>Q329N4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heptosyl transferase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfaC</name>
        <name evidence="2" type="ordered locus">SDY_4053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001211479.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405462.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329N4"/>
    <dbReference type="STRING" id="300267.SDY_4053"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63971">
        <property type="protein sequence ID" value="ABB63971"/>
        <property type="gene ID" value="SDY_4053"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4053"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4769"/>
    <dbReference type="HOGENOM" id="CLU_038371_6_0_6"/>
    <dbReference type="OMA" id="ITHLAWA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008920">
        <property type="term" value="F:lipopolysaccharide heptosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011908">
        <property type="entry name" value="LipoPS_heptosylTferase-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02193">
        <property type="entry name" value="heptsyl_trn_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="319" mass="35554" checksum="5D08996957DF579C" modified="2005-12-06" version="1">MRFLIVKTSSMGDVLHTLPALTDAQQAIPGIKFDWVVEEGFAQIPSWHAAVERVIPVAIRRWRKAWFSAPIKAERKAFREALQAENYDAVIDAQGLVKSAALVTRLAHGVKHGMDWQTAREPLASLFYNRKHHIAKQQHAVERTRELFAKSLGYSKPQTQGDYAIAQHFLTNLPTDAGEYAVFLHATTRDDKHWPEEHWRELIGLLADSGIRIKLPWGAPHEEERAKRLAEGFAYVEVLPKMSLEGVARVLAGAKFVVSVDTGLSHLTAALDRPNITVYGPTDPGLIGGYGKNQMVCRAPLKSLNNLEAAAVYKEITLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q329U2</accession>
    <name>Q329U2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YieP gene product</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yieP</name>
        <name evidence="5" type="ordered locus">SDY_3992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001131182.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405404.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329U2"/>
    <dbReference type="STRING" id="300267.SDY_3992"/>
    <dbReference type="EnsemblBacteria" id="ABB63913">
        <property type="protein sequence ID" value="ABB63913"/>
        <property type="gene ID" value="SDY_3992"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3992"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4700"/>
    <dbReference type="HOGENOM" id="CLU_017584_9_4_6"/>
    <dbReference type="OMA" id="WMTRENF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="230" mass="26105" checksum="CED37C3D68989217" modified="2005-12-06" version="1">MPLSAQQLAAQKNLSYVLAEKLAQRILKGEYEPGTILPSEIELGEQFGVSRTAVREAVKTLTAKGMVLPRPRIGTRVMPQSNWNFLDQELLTWWMTEENFHQVINHFLVMRICLEPQACLLAATVGTAEQKAHLNTLMAEMAALKENFRRERWIEVDMAWHEHIYEMSANPFLTSFASLFHSVYHTYFTSITSDTVIKLDLHQAIVDAIIQSDGDAAFKACQALLRSPDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q329V0</accession>
    <name>ILVD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="1">DAD</shortName>
            <ecNumber evidence="1">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ilvD</name>
        <name type="ordered locus">SDY_3977</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001127411.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405396.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329V0"/>
    <dbReference type="SMR" id="Q329V0"/>
    <dbReference type="STRING" id="300267.SDY_3977"/>
    <dbReference type="EnsemblBacteria" id="ABB63905">
        <property type="protein sequence ID" value="ABB63905"/>
        <property type="gene ID" value="SDY_3977"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3977"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4690"/>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_6"/>
    <dbReference type="OMA" id="TQGRNMA"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000225422" description="Dihydroxy-acid dehydratase">
        <location>
            <begin position="1"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <sequence length="616" mass="65600" checksum="33626AAD74C11CFE" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q329X6</accession>
    <name>Q329X6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aslA</name>
        <name evidence="6" type="ordered locus">SDY_3945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000395866.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405370.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329X6"/>
    <dbReference type="STRING" id="300267.SDY_3945"/>
    <dbReference type="EnsemblBacteria" id="ABB63879">
        <property type="protein sequence ID" value="ABB63879"/>
        <property type="gene ID" value="SDY_3945"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3945"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4656"/>
    <dbReference type="HOGENOM" id="CLU_006332_10_0_6"/>
    <dbReference type="OMA" id="PALEPCC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220961" evidence="4">
        <location>
            <begin position="25"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="86"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Ser)" evidence="3">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="551" mass="60810" checksum="1046E731050C02E2" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A55</accession>
    <name>Q32A55_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yihX</name>
        <name evidence="2" type="ordered locus">SDY_3858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A55"/>
    <dbReference type="STRING" id="300267.SDY_3858"/>
    <dbReference type="EnsemblBacteria" id="ABB63800">
        <property type="protein sequence ID" value="ABB63800"/>
        <property type="gene ID" value="SDY_3858"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3858"/>
    <dbReference type="HOGENOM" id="CLU_045011_9_5_6"/>
    <dbReference type="OMA" id="IDIDFNR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="206" mass="23561" checksum="542F7A27D45368F9" modified="2005-12-06" version="1">MARKEAKMLYIFDLGNVIVDIDFNRVLGAWSDLTRIPLATLKKSFHMGEAFHQHERGEISDEAFAEALCHEMALPLSYEQFSHGWQAVFVALRPEVIAIMHKLREQGHRVVVLSNTNRLHTTFWPEEYPEIRDAADHIYLSQDLGMRKPEARIYQHVLQAEGFSPSDTVFFDDNADNIEGANQLGITSILVKDKTTIPDYFAKVLC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AA2</accession>
    <name>RRAA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Regulator of ribonuclease activity A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rraA</name>
        <name type="ordered locus">SDY_3808</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RraA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000872906.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405244.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AA2"/>
    <dbReference type="SMR" id="Q32AA2"/>
    <dbReference type="STRING" id="300267.SDY_3808"/>
    <dbReference type="EnsemblBacteria" id="ABB63753">
        <property type="protein sequence ID" value="ABB63753"/>
        <property type="gene ID" value="SDY_3808"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3808"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4498"/>
    <dbReference type="HOGENOM" id="CLU_072626_4_0_6"/>
    <dbReference type="OMA" id="RSCDTQF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060698">
        <property type="term" value="F:endoribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00471">
        <property type="entry name" value="RraA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010203">
        <property type="entry name" value="RraA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014339">
        <property type="entry name" value="RraA_gpbac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01935">
        <property type="entry name" value="NOT-MenG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02998">
        <property type="entry name" value="RraA_entero"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000013873" description="Regulator of ribonuclease activity A">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00471"/>
        </source>
    </evidence>
    <sequence length="161" mass="17341" checksum="A6F691ADCD3E21F8" modified="2005-12-06" version="1">MKYDTSELCDIYQEDVNVVEPLFSNFGGRASFGGQIITVKCFEDNGLLYDLLEQNGRGRVLVVDGGGSVRRALVDAELARLAVQNEWEGLVIYGAVHQVDDLEELDIGIQAMAAIPVGAAGEGIGESDVRVNFGGVTFFSGDHLYADNTGIILSEDPLDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AD1</accession>
    <name>Q32AD1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yijF</name>
        <name evidence="2" type="ordered locus">SDY_3779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000648010.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405215.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AD1"/>
    <dbReference type="STRING" id="300267.SDY_3779"/>
    <dbReference type="EnsemblBacteria" id="ABB63724">
        <property type="protein sequence ID" value="ABB63724"/>
        <property type="gene ID" value="SDY_3779"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3779"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4469"/>
    <dbReference type="HOGENOM" id="CLU_079833_2_0_6"/>
    <dbReference type="OMA" id="PGNLPHI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009706">
        <property type="entry name" value="DUF1287"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06940">
        <property type="entry name" value="DUF1287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011444">
        <property type="entry name" value="DUF1287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220988" evidence="1">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="205" mass="23018" checksum="A780939FA55375B5" modified="2005-12-06" version="1">MKASLVLVSLLTAFTSHSLKSPAVPPTVVQIQANTNLAIADGARQQIGSTLFYDPAYMQLTYPGGDVPQERGVCSDVVISALRSQKVDLQKLVHEDMAKNFAEYPQKWQLKRLDSNIDHRRVPNLETWFTRHDKTRPISKNPSDYQAGDIASWRLDNGLAHIGVVSDGFARDGTPLVIHNIGAGAQEEDVLFSWRMVRHYRYFVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AG8</accession>
    <name>RSD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Regulator of sigma D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsd</name>
        <name type="ordered locus">SDY_3731</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with RpoD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rsd/AlgQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000934296.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405178.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AG8"/>
    <dbReference type="SMR" id="Q32AG8"/>
    <dbReference type="STRING" id="300267.SDY_3731"/>
    <dbReference type="EnsemblBacteria" id="ABB63687">
        <property type="protein sequence ID" value="ABB63687"/>
        <property type="gene ID" value="SDY_3731"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3731"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4423"/>
    <dbReference type="HOGENOM" id="CLU_142729_0_0_6"/>
    <dbReference type="OMA" id="DVIDHWL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01181">
        <property type="entry name" value="Rsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038309">
        <property type="entry name" value="Rsd/AlgQ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023785">
        <property type="entry name" value="Sigma70_reg_Rsd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007448">
        <property type="entry name" value="Sigma70_reg_Rsd_AlgQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04353">
        <property type="entry name" value="Rsd_AlgQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016548">
        <property type="entry name" value="Rsd_AlgQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000268888" description="Regulator of sigma D">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01181"/>
        </source>
    </evidence>
    <sequence length="158" mass="18231" checksum="CDA7E9CBD515EC08" modified="2005-12-06" version="1">MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLGGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLESNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AL5</accession>
    <name>Q32AL5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AL5"/>
    <dbReference type="EnsemblBacteria" id="ABB63640">
        <property type="protein sequence ID" value="ABB63640"/>
        <property type="gene ID" value="SDY_3675"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3675"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8625" checksum="46498828E3235D00" modified="2005-12-06" version="1">MITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIRTFIERHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AR3</accession>
    <name>Q32AR3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhhQ</name>
        <name evidence="2" type="ordered locus">SDY_3622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001100464.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405083.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AR3"/>
    <dbReference type="STRING" id="300267.SDY_3622"/>
    <dbReference type="EnsemblBacteria" id="ABB63592">
        <property type="protein sequence ID" value="ABB63592"/>
        <property type="gene ID" value="SDY_3622"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3622"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4298"/>
    <dbReference type="HOGENOM" id="CLU_090905_0_0_6"/>
    <dbReference type="OMA" id="IWLSLFH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="221" mass="25285" checksum="681DECD354E2E4DF" modified="2005-12-06" version="1">MNVFSQTQRYKALFWLSLFHLLVITSSNYLVQLPVSIFGFHTTWGAFSFPFIFLATDLTVRIFGAPLARRIIFAVMIPALLISYVISSLFYMGSWQGFGALAHFNLFVARIATASFMAYALGQILDVHVFNRLRQSRRWWLAPTASTLFGNVSDTLAFFFIAFWRSPDAFMAEHWIEIALVDYCFKVLISIVFFLPMYGVLLNMLLKRLADKSEINALQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AR9</accession>
    <name>Q32AR9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ftsY</name>
        <name evidence="8" type="ordered locus">SDY_3615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Contains an acidic N-terminal A domain, a central N domain and a C-terminal GTPase G domain that can bind and hydrolyze GTP. Contains at least two lipid-binding sites. The first site contains the first 14 amino acids (helix 1) and the second binding site is an amphipathic alpha-helix located at the interface between the A- and the N-domain (helix 2).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001040676.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405077.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AR9"/>
    <dbReference type="STRING" id="300267.SDY_3615"/>
    <dbReference type="EnsemblBacteria" id="ABB63586">
        <property type="protein sequence ID" value="ABB63586"/>
        <property type="gene ID" value="SDY_3615"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3615"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4291"/>
    <dbReference type="HOGENOM" id="CLU_009301_0_0_6"/>
    <dbReference type="OMA" id="GIEATDY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="301"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="383"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="447"/>
            <end position="450"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="498" mass="54714" checksum="9751169D2625FB4C" modified="2005-12-06" version="1">MAKEKKRGFFSWLGFGQKEQTPEKETEVQNEQPVVEEIVQAQEPVKASEQAVEEQPQAHTEAEAETFAAEVVEVTEQVAESEKAQPEAEVVAQPEPVVEETPEPVAIEREELPLPEDVNAEEVSPEEWQAEAETVEIVEAAEEEAAKEEITDEELETQALAAEAAEEAVMVVPPAEEEQPVEEIAQEQEKPTKEGFFARLKRSLLKTKENLGSGFISLFRGKKIDDDLFEELEEQLLIADVGVETTRKIITNLTEGASRKQLRDAEALYGLLKEEMGEILAKVDEPLNVEGKAPFVILMVGVNGVGKTTTIGKLARQFEQQGKSVMLAAGDTFRAAAVEQLQVWGQRNNIPVIAQHTGADSASVIFDAIQAAKARNIDVLIADTAGRLQNKSHLMEELKKIVRVMKKLDVEAPHEVMLTIDASTGQNAVSQAKLFHEAVGLTGITLTKLDGTAKGGVIFSVADQFGIPIRYIGVGERIEDLRPFKADDFIEALFARED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AW0</accession>
    <name>Q32AW0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1656</name>
        <name evidence="5" type="ordered locus">SDY_3571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61777">
        <property type="protein sequence ID" value="ABB61777"/>
        <property type="gene ID" value="SDY_1656"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63545">
        <property type="protein sequence ID" value="ABB63545"/>
        <property type="gene ID" value="SDY_3571"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1656"/>
    <dbReference type="KEGG" id="sdy:SDY_3571"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="118" mass="13389" checksum="46CF6832DA895605" modified="2005-12-06" version="1">MAVKPGNTGSGTRITPKQGGGLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B77</accession>
    <name>FIS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-binding protein Fis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fis</name>
        <name type="ordered locus">SDY_3438</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory Fis family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000462905.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404919.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B77"/>
    <dbReference type="SMR" id="Q32B77"/>
    <dbReference type="STRING" id="300267.SDY_3438"/>
    <dbReference type="EnsemblBacteria" id="ABB63428">
        <property type="protein sequence ID" value="ABB63428"/>
        <property type="gene ID" value="SDY_3438"/>
    </dbReference>
    <dbReference type="GeneID" id="8911232"/>
    <dbReference type="KEGG" id="sdy:SDY_3438"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4094"/>
    <dbReference type="HOGENOM" id="CLU_158040_3_0_6"/>
    <dbReference type="OMA" id="MVLCEVE"/>
    <dbReference type="PRO" id="PR:Q32B77"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00166">
        <property type="entry name" value="DNA_binding_Fis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005412">
        <property type="entry name" value="Fis_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002097">
        <property type="entry name" value="DNA-binding_Fis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01591">
        <property type="entry name" value="DNABINDNGFIS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000023346" description="DNA-binding protein Fis">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00166"/>
        </source>
    </evidence>
    <sequence length="98" mass="11240" checksum="2E339BFCFCDB163C" modified="2005-12-06" version="1">MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B84</accession>
    <name>Q32B84_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B84"/>
    <dbReference type="EnsemblBacteria" id="ABB63421">
        <property type="protein sequence ID" value="ABB63421"/>
        <property type="gene ID" value="SDY_3431"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3431"/>
    <dbReference type="HOGENOM" id="CLU_3309497_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="39" mass="4634" checksum="9607C3FC26905A1D" modified="2005-12-06" version="1">MNNLILFDYKLITRTYLMLSIVNRLILRALAFTSIQTMQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BA3</accession>
    <name>MDH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Malate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mdh</name>
        <name type="ordered locus">SDY_3412</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018898.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404893.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BA3"/>
    <dbReference type="SMR" id="Q32BA3"/>
    <dbReference type="STRING" id="300267.SDY_3412"/>
    <dbReference type="EnsemblBacteria" id="ABB63402">
        <property type="protein sequence ID" value="ABB63402"/>
        <property type="gene ID" value="SDY_3412"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3412"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4070"/>
    <dbReference type="HOGENOM" id="CLU_047181_0_1_6"/>
    <dbReference type="OMA" id="MGWTSQA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01516">
        <property type="entry name" value="Malate_dehydrog_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023958">
        <property type="entry name" value="Malate_DH_type1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="chain" id="PRO_0000294309" description="Malate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01516"/>
        </source>
    </evidence>
    <sequence length="312" mass="32326" checksum="8D1CAF7B46D068AA" modified="2005-12-06" version="1">MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVARKPGMDRSDLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVLGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKSGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGEEFVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BI5</accession>
    <name>Q32BI5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Penicillin-binding protein activator LpoA</fullName>
            <shortName evidence="7">PBP activator LpoA</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yraM</name>
        <name evidence="7" type="synonym">lpoA</name>
        <name evidence="10" type="ordered locus">SDY_3326</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with PBP1a.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the LpoA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000249095.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404811.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BI5"/>
    <dbReference type="STRING" id="300267.SDY_3326"/>
    <dbReference type="EnsemblBacteria" id="ABB63320">
        <property type="protein sequence ID" value="ABB63320"/>
        <property type="gene ID" value="SDY_3326"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3326"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3979"/>
    <dbReference type="HOGENOM" id="CLU_026091_1_1_6"/>
    <dbReference type="OMA" id="MRLYAMG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031241">
        <property type="term" value="C:periplasmic side of cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01890">
        <property type="entry name" value="LpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007443">
        <property type="entry name" value="LpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008939">
        <property type="entry name" value="Lytic_TGlycosylase_superhlx_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38038">
        <property type="entry name" value="PTHR38038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04348">
        <property type="entry name" value="LppC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48435">
        <property type="entry name" value="SSF48435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="3 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008969457" description="Penicillin-binding protein activator LpoA" evidence="9">
        <location>
            <begin position="26"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="678" mass="72729" checksum="21E84AF0A4DAAD91" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BL6</accession>
    <name>Q32BL6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yqjG</name>
        <name evidence="3" type="ordered locus">SDY_3291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000531205.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404780.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BL6"/>
    <dbReference type="SMR" id="Q32BL6"/>
    <dbReference type="STRING" id="300267.SDY_3291"/>
    <dbReference type="EnsemblBacteria" id="ABB63289">
        <property type="protein sequence ID" value="ABB63289"/>
        <property type="gene ID" value="SDY_3291"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3291"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3933"/>
    <dbReference type="HOGENOM" id="CLU_037263_0_1_6"/>
    <dbReference type="OMA" id="PWANRAI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="172"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="328" mass="37466" checksum="D23C31F975BCD509" modified="2005-12-06" version="1">MGQLIDGVWHDTWYDTKSTGGKFQRSASAFRNWLTADGAPGPTGTGGFIAEKDRYHLYVSLACPWAHRTLIMRKLKGLEPFISVSVVNPLMLENGWTFDDSFPGATGDTLYQHEFLYQLYLHADPHYSGRVTVPVLWDKKNHTIVSNESAEIIRMFNTAFDALGAKAGDYYPPALQTKIDELNGWIYDTVNNGVYKAGFATSQQAYDEAVEKVFESLARLEQILGQHRYLTGNQLTEADIRLWTTLVRFDPVYVTHFKCDKHRISDYLNLYGFLRDIYQMPGIAETVNFDHIRNHYFRSHKTINPTGIISIGPWQDLDEPHGRDVRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BP0</accession>
    <name>Q32BP0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NADPH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ygjL</name>
        <name evidence="4" type="ordered locus">SDY_3265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000121488.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404756.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BP0"/>
    <dbReference type="STRING" id="300267.SDY_3265"/>
    <dbReference type="EnsemblBacteria" id="ABB63265">
        <property type="protein sequence ID" value="ABB63265"/>
        <property type="gene ID" value="SDY_3265"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3265"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3904"/>
    <dbReference type="HOGENOM" id="CLU_012153_1_1_6"/>
    <dbReference type="OMA" id="QFLAAHT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="5"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="376"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="672" mass="72816" checksum="0FBE8A9FEBE17F20" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BP6</accession>
    <name>Q32BP6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aerotaxis sensor receptor, flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">aer</name>
        <name evidence="11" type="ordered locus">SDY_3256</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000094663.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404750.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BP6"/>
    <dbReference type="STRING" id="300267.SDY_3256"/>
    <dbReference type="EnsemblBacteria" id="ABB63259">
        <property type="protein sequence ID" value="ABB63259"/>
        <property type="gene ID" value="SDY_3256"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3256"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3890"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_26_6"/>
    <dbReference type="OMA" id="PAMPLRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="263"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="506" mass="55115" checksum="9961689B1E741906" modified="2005-12-06" version="1">MSSHPYVTQQNTPLADDTTLMSATDLQSYITHANDTFVQVSGYTLQELQGQPHNMVRHPDMPKAAFADMWFTLKKGEPWSGIVKNRRKNGDHYWERANAVPMVREGKISGYMSIRTRATDEEIAAVEPLYKALNAGRTGKRIHKGLVVRKGWLSKLPSLPLRWRARGVMTLMFILLAAMLWFVAAPVVTYILCALVVLLASACFEWQIVRPIENVARQALKVATGERNSVEHLNRSDELGLTLRAVGQLGLMCRWLINDVSSQVSSVRNGSETLAKGTDELNEHTQQTVDNVQQTVATMNQMAASVKQNSATASAADKLSITASNAAVQGGEAMTTEIKTMDDIADSTQRIGTITSLINDIAFQTNILALNAAVEAARAGEQGKGFAVVAGEVRHLASRSANAANDIRKLIDASADKVQSGSQQVHAAGRTMEDIVAQVKNVTQLIAQISHSTLEQADGLSSLTRAVDELNLITQKNAELVEESAQVSAMVKHRASRLEDAVTVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C34</accession>
    <name>Q32C34_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ornithine decarboxylase isozyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">speC</name>
        <name evidence="8" type="ordered locus">SDY_3107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000839556.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404612.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C34"/>
    <dbReference type="STRING" id="300267.SDY_3107"/>
    <dbReference type="EnsemblBacteria" id="ABB63121">
        <property type="protein sequence ID" value="ABB63121"/>
        <property type="gene ID" value="SDY_3107"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3107"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3716"/>
    <dbReference type="HOGENOM" id="CLU_014292_3_0_6"/>
    <dbReference type="OMA" id="MKGRSGE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00615">
        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005308">
        <property type="entry name" value="OKR_de-COase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011193">
        <property type="entry name" value="Orn/lys/arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027464">
        <property type="entry name" value="Ornithine_deCO2ase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03709">
        <property type="entry name" value="OKR_DC_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009393">
        <property type="entry name" value="Orn_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1" evidence="5">
        <location>
            <begin position="101"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="7">
        <location>
            <begin position="568"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR009393-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="711" mass="79598" checksum="D0543E6D19D4D6BF" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CS9</accession>
    <name>Q32CS9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sfhB</name>
        <name evidence="6" type="ordered locus">SDY_2837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000079122.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404367.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CS9"/>
    <dbReference type="STRING" id="300267.SDY_2837"/>
    <dbReference type="EnsemblBacteria" id="ABB62876">
        <property type="protein sequence ID" value="ABB62876"/>
        <property type="gene ID" value="SDY_2837"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2837"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3410"/>
    <dbReference type="HOGENOM" id="CLU_016902_4_0_6"/>
    <dbReference type="OMA" id="AHPSPGW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="326" mass="37209" checksum="4390739F965CC40A" modified="2005-12-06" version="1">MAQRVQLTATVSENQLGQRLDQALAEMFPDYSRSRIKEWILDQRVLVNSKLCDKPKEKVLGGEQVAINAEIEEEARFEPQDIPLDIVYEDEDIIVINKPRDLVVHPGAGNPDSTVLNALLHYYPPIADVPRAGIVHRLDKDTTGLMVVAKTVPAQRRLVESLQRREITREYEAVAIGHMTAGGTVDEPISRHPTKRTHMAVHPMGKPAVTHYRIMEHFRVHTRLRLRLETGRTHQIRVHMAHITHPLVGDPVYGGRPRPPKGASEAFISTLRKFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIEAMRADFEEHKDEVDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CT1</accession>
    <name>Q32CT1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">clpB</name>
        <name evidence="13" type="ordered locus">SDY_2835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005023880.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404365.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CT1"/>
    <dbReference type="STRING" id="300267.SDY_2835"/>
    <dbReference type="EnsemblBacteria" id="ABB62874">
        <property type="protein sequence ID" value="ABB62874"/>
        <property type="gene ID" value="SDY_2835"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2835"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3408"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_6"/>
    <dbReference type="OMA" id="SKMMQGE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 13" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="412"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB62874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="857" mass="95613" checksum="25E4405E6E7F54DD" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D17</accession>
    <name>Q32D17_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alpha helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yfhG</name>
        <name evidence="3" type="ordered locus">SDY_2745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001215867.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404279.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D17"/>
    <dbReference type="STRING" id="300267.SDY_2745"/>
    <dbReference type="EnsemblBacteria" id="ABB62788">
        <property type="protein sequence ID" value="ABB62788"/>
        <property type="gene ID" value="SDY_2745"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2745"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3310"/>
    <dbReference type="HOGENOM" id="CLU_068067_1_0_6"/>
    <dbReference type="OMA" id="SLYWLRA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025262">
        <property type="entry name" value="QseG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13942">
        <property type="entry name" value="Lipoprotein_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221046" evidence="2">
        <location>
            <begin position="23"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27392" checksum="782A54B4924C54B1" modified="2005-12-06" version="1">MRHIFQRLLPRRLWLAGLPCLALLGCVQNHNKPAIDTPTEEKIPVYQLADYLSTECSDIWALQGKSTETNPLYWLRAMDCADRLMPAQSRQQARQYDDGSWQNTFKQGILLADAKITPYERRQLVARIDALSTEIPAQVRPLYQLWRDGQALQLQLAEERQRYGKLQQSSDSELDTLRQQHHVLQQQLELTTRKLENLTDIERQLSTRKPAGNFSPDTPHESEKPEPSTHEVTPDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D59</accession>
    <name>Q32D59_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative outer membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378838.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404237.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D59"/>
    <dbReference type="STRING" id="300267.SDY_2699"/>
    <dbReference type="EnsemblBacteria" id="ABB62746">
        <property type="protein sequence ID" value="ABB62746"/>
        <property type="gene ID" value="SDY_2699"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2699"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3257"/>
    <dbReference type="HOGENOM" id="CLU_112454_0_0_6"/>
    <dbReference type="OMA" id="QSNADEH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221026" evidence="1">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Rick_17kDa_Anti" evidence="2">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="176" mass="18212" checksum="1D5D01262179943C" modified="2005-12-06" version="1">MMKFKKCLLPVAMLASFTLAGCQSNADDHAADVYQTDQLNTKQETKTVNIISILPAKVAVDNSQNKRNAQAFGALIGAVAGGVIGHNVGSGSNSGTTAGAVGGGAVGAAAGSMVNDKTLVEGVSLTYKEGTKVYTSTQVGKECQFTTGLAVVITTTYNETRIQLDLPLYFQTSVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D68</accession>
    <name>Q32D68_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase</fullName>
            <shortName evidence="3">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purN</name>
        <name evidence="5" type="ordered locus">SDY_2689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001028628.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404228.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D68"/>
    <dbReference type="STRING" id="300267.SDY_2689"/>
    <dbReference type="EnsemblBacteria" id="ABB62737">
        <property type="protein sequence ID" value="ABB62737"/>
        <property type="gene ID" value="SDY_2689"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2689"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3244"/>
    <dbReference type="HOGENOM" id="CLU_038395_1_1_6"/>
    <dbReference type="OMA" id="TGITIHY"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="3">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="212" mass="23268" checksum="F5544129118043B2" modified="2005-12-06" version="1">MNIVVLISGNGSNLQAIIDACKTNKIKGTVRAVFSNKADAFGLERARQAGIATHTLITSAFDSREAYDRELIHEIDMYAPDVVVLAGFMRILSPAFVSHYAGRLLNIHPSLLPKYPGLHTHRQALENGDEEHGTSVHFVTDELDGGPVILQAKVPVFAGDTEDDVTARVQTQEHAIYPLVISWFADGRLKMHENAAWLDGQRLPPQGYAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D89</accession>
    <name>Q32D89_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D89"/>
    <dbReference type="EnsemblBacteria" id="ABB62716">
        <property type="protein sequence ID" value="ABB62716"/>
        <property type="gene ID" value="SDY_2665"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2665"/>
    <dbReference type="HOGENOM" id="CLU_193660_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9717" checksum="FD5541E4EBCCB155" modified="2005-12-06" version="1">MCRMFCRMRRERLIRTTSDKQISCELPLKSRFPADAHVCVSYQKKGPDDSSPVFLLAKRSLEDSYQRVVLTLSQSMTFRIDEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DE6</accession>
    <name>SYE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="1">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gltX</name>
        <name type="ordered locus">SDY_2600</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000695636.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404150.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DE6"/>
    <dbReference type="SMR" id="Q32DE6"/>
    <dbReference type="STRING" id="300267.SDY_2600"/>
    <dbReference type="EnsemblBacteria" id="ABB62659">
        <property type="protein sequence ID" value="ABB62659"/>
        <property type="gene ID" value="SDY_2600"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2600"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3138"/>
    <dbReference type="HOGENOM" id="CLU_015768_6_0_6"/>
    <dbReference type="OMA" id="HYINTLP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000237400" description="Glutamate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <sequence length="471" mass="53814" checksum="6F31EA854CC215BE" modified="2005-12-06" version="1">MKIKTRFAPSPTGYLHVGGARTALYSWLFARNHGGEFVLRIEDTDLERSTPEAIEAIMDGMNWLSLEWDEGPYFQTKRFDRYNAVIDQMLEEGTAYKCYCSKERLEALREEQMAKGEKPRYDDRCRHSHEHHADDEPCVVRFANPQEGSVVFDDQIRGPIEFSNQELDDLIIRRTDGSPTYNFCVVVDDWDMEITHVIRGEDHINNTPRQINILKALKAPVPVYAHVSMINGDDGKKLSKRHGAVSVMQYRDDGYLPEALLNYLVRLGWSHGDQEIFTREEMIKYFTLNAVSKSASAFNTDKLLWLNHHYINALPPEYVATHLQWHIEQENIDTRNGPQLADLVKLLGERCKTLKEMAQSCRYFYEDFAEFDADAAKKHLRPVARQPLEVVRDKLAAITDWTAENVHHAIQATADELEVGMGKVGMPLRVAVTGAGQSPALDVTVHAIGKTRSIERINKALAFIAERENQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DQ7</accession>
    <name>NUOH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoH</name>
        <name type="ordered locus">SDY_2478</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000118507.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404039.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DQ7"/>
    <dbReference type="SMR" id="Q32DQ7"/>
    <dbReference type="STRING" id="300267.SDY_2478"/>
    <dbReference type="EnsemblBacteria" id="ABB62548">
        <property type="protein sequence ID" value="ABB62548"/>
        <property type="gene ID" value="SDY_2478"/>
    </dbReference>
    <dbReference type="GeneID" id="67416712"/>
    <dbReference type="KEGG" id="sdy:SDY_2478"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2989"/>
    <dbReference type="HOGENOM" id="CLU_015134_0_1_6"/>
    <dbReference type="OMA" id="WSGWASN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000244953" description="NADH-quinone oxidoreductase subunit H">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <sequence length="325" mass="36219" checksum="0648FD831E1B8FB0" modified="2005-12-06" version="1">MSWISPELIEILLTILKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWIPKFSDRVIFTLAPMIAFTSLLLAFAIVPVSPGWVVADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFLGLSLMGVVAQAGSFNMTDIVNSQAHVWNVIPQFFGFITFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTISALMVTLFFGGWQGPLLPPFIWFALKTAFFMMMFILIRASLPRPRYDQVMSFGWKICLPLTLINLLVTAAVILWQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DT8</accession>
    <name>Q32DT8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DT8"/>
    <dbReference type="STRING" id="300267.SDY_2446"/>
    <dbReference type="EnsemblBacteria" id="ABB62517">
        <property type="protein sequence ID" value="ABB62517"/>
        <property type="gene ID" value="SDY_2446"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2446"/>
    <dbReference type="HOGENOM" id="CLU_062618_8_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IclR-ED" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="136" mass="15203" checksum="28B001873F4BAA9E" modified="2005-12-06" version="1">MRSHEGKSLSLYRSGIGKCLLAWQPATVQQSIIEGLVWEQATPTTITHPQQLHEELARIRRQGWSYDNGEDYADVRCVAAPVFNANNELTAAISVVGTRLQINEEYRDYLAGKAIACARDISRLLGWKSPFDLQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DX7</accession>
    <name>Q32DX7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding component of 3rd arginine transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">artP</name>
        <name evidence="8" type="ordered locus">SDY_2404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000027205.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403969.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DX7"/>
    <dbReference type="SMR" id="Q32DX7"/>
    <dbReference type="STRING" id="300267.SDY_2404"/>
    <dbReference type="EnsemblBacteria" id="ABB62478">
        <property type="protein sequence ID" value="ABB62478"/>
        <property type="gene ID" value="SDY_2404"/>
    </dbReference>
    <dbReference type="GeneID" id="66670862"/>
    <dbReference type="KEGG" id="sdy:SDY_2404"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2901"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="DMVPCEL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="242" mass="27022" checksum="D5B50062E523413A" modified="2005-12-06" version="1">MSIQLNGINCFYGAHQALFDITLDCPQGETLVLLGPSGAGKSSLLRVLNLLEMPRSGTLNIAGNHFDFTKTPSDKAIRDLRRNVGMVFQQYNLWPHLTVQQNLIEAPCRVLGLSKDQALARAEKLLERLRLKPYSDRYPLHLSGGQQQRVAIARALMMEPQVLLFDEPTAALDPEITAQIVSIIRELAETNITQVIVTHEVEVARKTASRVVYMENGHIVEQGDASCFTEPQTEAFKNYLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E09</accession>
    <name>Q32E09_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA translocase FtsK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ftsK</name>
        <name evidence="14" type="ordered locus">SDY_2371</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000076991.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403937.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E09"/>
    <dbReference type="STRING" id="300267.SDY_2371"/>
    <dbReference type="EnsemblBacteria" id="ABB62446">
        <property type="protein sequence ID" value="ABB62446"/>
        <property type="gene ID" value="SDY_2371"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2371"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2864"/>
    <dbReference type="HOGENOM" id="CLU_001981_0_1_6"/>
    <dbReference type="OMA" id="DPFWKPG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="13">
        <location>
            <begin position="1013"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="434"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="576"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="651"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="737"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="1030"/>
            <end position="1037"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB62446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1368" mass="151327" checksum="98876740BE4C9237" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E72</accession>
    <name>Q32E72_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000489580.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403874.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E72"/>
    <dbReference type="STRING" id="300267.SDY_2306"/>
    <dbReference type="EnsemblBacteria" id="ABB62383">
        <property type="protein sequence ID" value="ABB62383"/>
        <property type="gene ID" value="SDY_2306"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2306"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2783"/>
    <dbReference type="HOGENOM" id="CLU_155233_3_1_6"/>
    <dbReference type="OMA" id="PCEISAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221063" evidence="1">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="103" mass="11138" checksum="741C678DBF8D2E52" modified="2005-12-06" version="1">MFRPFLNSLMLGSLFFPFIAIAGSTAQGGVIHFYGQIVEPACDVSTQSSPVEMNCPQNGSVPGKTYSSKALMSGNVKNAQVASVKVQYLDKQKKLAVMNIEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E82</accession>
    <name>Q32E82_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403864.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E82"/>
    <dbReference type="STRING" id="300267.SDY_2296"/>
    <dbReference type="EnsemblBacteria" id="ABB62373">
        <property type="protein sequence ID" value="ABB62373"/>
        <property type="gene ID" value="SDY_2296"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2296"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2773"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_9_6"/>
    <dbReference type="OMA" id="RIRPAHW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11542" checksum="7EB6010BB9D1CBCA" modified="2005-12-06" version="1">MKKRNFSAEFKRESAQLVVDQNYTVADAAKAMDVGLSTMTRWVKQLRDERQGKTPKASPITPEQIEIRELRKKLQRIEMENEMLKKATALLMSDSLNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EC5</accession>
    <name>Q32EC5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403821.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EC5"/>
    <dbReference type="STRING" id="300267.SDY_2249"/>
    <dbReference type="EnsemblBacteria" id="ABB62330">
        <property type="protein sequence ID" value="ABB62330"/>
        <property type="gene ID" value="SDY_2249"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2249"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2718"/>
    <dbReference type="HOGENOM" id="CLU_096393_0_0_6"/>
    <dbReference type="OMA" id="YENRTSK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="282" mass="31428" checksum="BB322980E9F6D3F9" modified="2005-12-06" version="1">MGLTISRYIGAVAILWVLAIGFNPALRISLKSYFKPLNFSIIWEVMGIGIPASVESVLFTSGRLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGSALGSASTIITGRRLGVGQIAQAEIQLRHVFWLSTLGLTAIAWLTAPFAGLMASFYTQDPQVKHVVVILIWLNALFMPIWSASWVLPAGFKGARDARYAMWVSMLSMWGCRVVVGYVLGIMLGWGVVGVWMGMFADWAVRAVLFYWRMVTGRWLWKYPRPEPQKCEKSQLCRNKRQNADYFSKRFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EI3</accession>
    <name>Q32EI3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional response regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">baeR</name>
        <name evidence="6" type="ordered locus">SDY_2186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000137877.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403763.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EI3"/>
    <dbReference type="SMR" id="Q32EI3"/>
    <dbReference type="STRING" id="300267.SDY_2186"/>
    <dbReference type="EnsemblBacteria" id="ABB62272">
        <property type="protein sequence ID" value="ABB62272"/>
        <property type="gene ID" value="SDY_2186"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2186"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2644"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_6"/>
    <dbReference type="OMA" id="IMITARV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="12"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="131"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="131"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="240" mass="27656" checksum="8E2F6C9EB911C9CC" modified="2005-12-06" version="1">MTELPIDENTPRILIVEDEPKLGQLLIDYLRAASYAPTLISHGDQVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPQRELQQQDAESPLIIDEGRFQASWRGKMLDLTPAEFRLLKTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGYRWEADACRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EN1</accession>
    <name>Q32EN1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_2135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403715.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EN1"/>
    <dbReference type="EnsemblBacteria" id="ABB62224">
        <property type="protein sequence ID" value="ABB62224"/>
        <property type="gene ID" value="SDY_2135"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2135"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2577"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14877" checksum="B1657C0D70193B4A" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGCLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ET0</accession>
    <name>Q32ET0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative virulence factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mviM</name>
        <name evidence="2" type="ordered locus">SDY_2084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000736132.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403666.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ET0"/>
    <dbReference type="STRING" id="300267.SDY_2084"/>
    <dbReference type="EnsemblBacteria" id="ABB62175">
        <property type="protein sequence ID" value="ABB62175"/>
        <property type="gene ID" value="SDY_2084"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2084"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2506"/>
    <dbReference type="HOGENOM" id="CLU_023194_23_0_6"/>
    <dbReference type="OMA" id="HPRELIL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="307" mass="33647" checksum="C316FC3D9139C59E" modified="2005-12-06" version="1">MKKLRIGVVGLGGIAQKAWLPVLAAASDWMLQGAWSPTRAKALSICESWRIPYADSLSSLAASCDAVFVHSSTASHFDVVSTLLNAGVHVCVDKPLAENLRDAERLVELAARKKLTLMVGFNRRFAPLYGGLKTQLATAASLRMDKYRSNSVGPHDLYFTLLDDYLHVVDTALWLSGGKASLDGGTLLTNDAGEMLFAEHHFSAGPLQITTCMHRRAGSQRETVQAVTDGALIDITEMREWREERGQGVVNKPIPGWQSTLEQRGFVGCARHFIECVQNQTVPQTAGEQAVLAQRIVDKIWRDAMSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EZ1</accession>
    <name>MNMA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="1">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmA</name>
        <name type="ordered locus">SDY_2019</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with TusE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62114" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62114.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022119.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403605.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EZ1"/>
    <dbReference type="SMR" id="Q32EZ1"/>
    <dbReference type="STRING" id="300267.SDY_2019"/>
    <dbReference type="PRIDE" id="Q32EZ1"/>
    <dbReference type="EnsemblBacteria" id="ABB62114">
        <property type="protein sequence ID" value="ABB62114"/>
        <property type="gene ID" value="SDY_2019"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2019"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2432"/>
    <dbReference type="HOGENOM" id="CLU_035188_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000349797" description="tRNA-specific 2-thiouridylase MnmA">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with target base in tRNA" evidence="1">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="1">
        <location>
            <begin position="102"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="368" mass="40988" checksum="BE8E611F78A95090" modified="2008-09-02" version="2">MSETAKKVIVGMSGGVDSSVSAWLLQQQGYQVEGLFMKNWEEDDGEEYCTAAADLADAQAVCDKLGIELHTVNFAAEYWDNVFELFLAEYKAGRTPNPDILCNKEIKFKAFLEFAAEDLGADYIATGHYVRRADVDGKSRLLRGLDSNKDQSYFLYTLSHEQIAKSLFPVGELEKPQVRKIAEDLGLVTAKKKDSTGICFIGERKFREFLGRYLPAQPGKIITVDGDEIGEHQGLMYHTLGQRKGLGIGGTKEGTEEPWYVVDKDVENNILIVAQGHEHPRLMSIGLIAQQLHWVDREPFTGTMRCTVKTRYRQTDIPCTVKALDDDRIEVIFDEPVAAVTPGQSAVFYNGEVCLGGGIIEQRLPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F09</accession>
    <name>Q32F09_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ipaH_4</name>
        <name evidence="13" type="ordered locus">SDY_2001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LRR-containing bacterial E3 ligase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378765.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403587.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F09"/>
    <dbReference type="STRING" id="300267.SDY_2001"/>
    <dbReference type="EnsemblBacteria" id="ABB62096">
        <property type="protein sequence ID" value="ABB62096"/>
        <property type="gene ID" value="SDY_2001"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2001"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2410"/>
    <dbReference type="HOGENOM" id="CLU_018533_2_0_6"/>
    <dbReference type="OMA" id="ETEIFFR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032674">
        <property type="entry name" value="LRR_E3_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029487">
        <property type="entry name" value="NEL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14496">
        <property type="entry name" value="NEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12468">
        <property type="entry name" value="TTSSLRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="TTSSLRR" evidence="11">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="NEL" evidence="12">
        <location>
            <begin position="287"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB62096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="571" mass="64930" checksum="AF331E25F4D15E70" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FA4</accession>
    <name>Q32FA4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_0381</name>
        <name evidence="5" type="ordered locus">SDY_1895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402083.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403492.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0381"/>
    <dbReference type="EnsemblBacteria" id="ABB60594">
        <property type="protein sequence ID" value="ABB60594"/>
        <property type="gene ID" value="SDY_0381"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62001">
        <property type="protein sequence ID" value="ABB62001"/>
        <property type="gene ID" value="SDY_1895"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0381"/>
    <dbReference type="KEGG" id="sdy:SDY_1895"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2279"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="OMA" id="STAYFAQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11210" checksum="2973A770DE4B3701" modified="2005-12-06" version="1">MSRKTQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGTLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKTTAYFAQESLKNTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FD5</accession>
    <name>PDXH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="1">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PNP/PMP oxidase</fullName>
            <shortName evidence="1">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxH</name>
        <name type="ordered locus">SDY_1861</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001282319.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403461.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FD5"/>
    <dbReference type="SMR" id="Q32FD5"/>
    <dbReference type="STRING" id="300267.SDY_1861"/>
    <dbReference type="EnsemblBacteria" id="ABB61970">
        <property type="protein sequence ID" value="ABB61970"/>
        <property type="gene ID" value="SDY_1861"/>
    </dbReference>
    <dbReference type="GeneID" id="58462440"/>
    <dbReference type="KEGG" id="sdy:SDY_1861"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2240"/>
    <dbReference type="HOGENOM" id="CLU_032263_2_2_6"/>
    <dbReference type="OMA" id="PEPNAMV"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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        </location>
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        <ligand>
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        <location>
            <begin position="67"/>
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        <ligand>
            <name>FMN</name>
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        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
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        <ligand>
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        <ligand>
            <name>substrate</name>
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        <ligand>
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    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <sequence length="218" mass="25545" checksum="8B47CEEEA6CEF5F9" modified="2005-12-06" version="1">MSDNDELQQIAHLRREYTKGGLRRRDLPADPLTLFERWLSQACEAKLADPTAMVVATVDEHGQPYQRIVLLKHYDEKGMVFYTNLGSRKAHQIENNPRVSLLFPWHTLERQVMVIGKAERLSTLEVMKYFHSRPRDSQIGAWVSKQSSRISARGILESKFLELKQKFQQGEVPLPSFWGGFRVSLEQIEFWQGGEHRLHDRFLYQRENDAWKIDRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FM4</accession>
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        <submittedName>
            <fullName evidence="4">Cytochrome b(561)</fullName>
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        <name evidence="4" type="primary">cybB</name>
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        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1764"/>
    <dbReference type="HOGENOM" id="CLU_095321_3_0_6"/>
    <dbReference type="OMA" id="FIKGWHE"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
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        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
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            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="188" mass="21577" checksum="F5143574E4CE1557" modified="2005-12-06" version="1">MLTENYVKAGNVMENKYSRLQIGIHWLVFLLVIAAYCAMEFRGFFPRSDRPLINMIHVSCGISILVLMVVRLLLRLKYPTPPIIPKPKPMMTGLAHLGHLVIYLLFIALPVIGLVMMYNRGNPWFAFGLTMPYASEANFERVDSLKSWHETLANLGYFVIGLHAAAALAHHYFWKDNTLLRMMPRKRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FQ5</accession>
    <name>ABDH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-aminobutyraldehyde dehydrogenase</fullName>
            <shortName evidence="1">ABALDH</shortName>
            <ecNumber evidence="1">1.2.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-pyrroline dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">4-aminobutanal dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">5-aminopentanal dehydrogenase</fullName>
            <ecNumber evidence="1">1.2.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">patD</name>
        <name type="ordered locus">SDY_1730</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58264"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="1.2.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:19106"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-aminopentanal + H2O + NAD(+) = 5-aminopentanoate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:61632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:144896"/>
            <dbReference type="ChEBI" id="CHEBI:356010"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:61633"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">4-aminobutanal can spontaneously cyclize to 1-pyrroline, and 5-aminopentanal to 1-piperideine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.19" evidence="1"/>
    <dbReference type="EC" id="1.2.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001163896.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403341.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FQ5"/>
    <dbReference type="SMR" id="Q32FQ5"/>
    <dbReference type="STRING" id="300267.SDY_1730"/>
    <dbReference type="EnsemblBacteria" id="ABB61850">
        <property type="protein sequence ID" value="ABB61850"/>
        <property type="gene ID" value="SDY_1730"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1730"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2086"/>
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    <dbReference type="OMA" id="NDDLGEV"/>
    <dbReference type="UniPathway" id="UPA00188">
        <property type="reaction ID" value="UER00292"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033737">
        <property type="term" value="F:1-pyrroline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019145">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
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    </dbReference>
    <dbReference type="GO" id="GO:0019477">
        <property type="term" value="P:L-lysine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009447">
        <property type="term" value="P:putrescine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07092">
        <property type="entry name" value="ALDH_ABALDH-YdcW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01275">
        <property type="entry name" value="Aldedh_Prr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015657">
        <property type="entry name" value="Aminobutyraldehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017749">
        <property type="entry name" value="PatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03374">
        <property type="entry name" value="ABALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000269701" description="Gamma-aminobutyraldehyde dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="172"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="225"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01275"/>
        </source>
    </evidence>
    <sequence length="474" mass="50881" checksum="B744AD5D2A467164" modified="2005-12-06" version="1">MQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAVGEYLEGHTSMIRRDPLGVVASIAPWNYLLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVINVLFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTAPSIKRTHMELGGKAPVIVFDDANIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVSKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFILVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FS2</accession>
    <name>Q32FS2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403324.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FS2"/>
    <dbReference type="STRING" id="300267.SDY_1713"/>
    <dbReference type="EnsemblBacteria" id="ABB61833">
        <property type="protein sequence ID" value="ABB61833"/>
        <property type="gene ID" value="SDY_1713"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1713"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2067"/>
    <dbReference type="HOGENOM" id="CLU_100715_6_1_6"/>
    <dbReference type="OMA" id="GEMNAVW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06150">
        <property type="entry name" value="YjgF_YER057c_UK114_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035709">
        <property type="entry name" value="YoaB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47328">
        <property type="entry name" value="PTHR47328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="130" mass="14415" checksum="00266634FC50B092" modified="2005-12-06" version="1">MAVFAARKWKDNEDKMMTIVRIDAEARWSDVVIHNNTLYYTGVPENLDADAFEQTANTLAQIDAVLEKQGSNKSSILDATIFLADKNDFAAMNKAWDAWVVAGHAPVRCTVQAGLMNPKYKVEIKIVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FY2</accession>
    <name>Q32FY2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cryptic nitrate reductase 2, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">narY</name>
        <name evidence="2" type="ordered locus">SDY_1651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000702520.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403264.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FY2"/>
    <dbReference type="STRING" id="300267.SDY_1651"/>
    <dbReference type="EnsemblBacteria" id="ABB61773">
        <property type="protein sequence ID" value="ABB61773"/>
        <property type="gene ID" value="SDY_1651"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1651"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1991"/>
    <dbReference type="HOGENOM" id="CLU_043374_5_2_6"/>
    <dbReference type="OMA" id="CNACAHS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10557">
        <property type="entry name" value="NarH_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="507" mass="57624" checksum="7BADC731353651E9" modified="2005-12-06" version="1">MKIRSQVGMVLNLDKCIGCHTCSVTCKNVWTGREGMEYAWFNNAETKPGIGYPKNWEDQEEWQGGWVRDVNGKIRPRLGSKMGVITKIFANPVVPQIDDYYEHLHSAPEGKHIPTARPRSLIDGKRMDKVIWGPNWEELLGGEFEKRARDRNFEAMQKEMYGQFENTFMMYLPRLCEHCLNPSCVATCPSGAIYKREEDGIVLIDQDKCRGWRLCISGCPYKKIYFNWKSGKSEKCIFCYPRIESGQPTVCSETCVGRIRYLGVLLYDADRIEEAASTEREVDLYERQCEVFLDPQDPSVIEEALKQGIPQNVIDAAQRSPVYKMAMDWKLALPLHPEYRTLPMVWYVPPLSPIQSYADAGGLPKSEGVLPAIESLRIPVQYLANMLSAGDTGPVLRALKWMMAMRHYMRSQTVEGVTDTRAIDEVGLSVAQVEEMYRYLAIANYEDRFVIPTSHREMAGDAFAERNGCGFTFGDGCHGSDSKFNLFNSSRIDAINITEVRDKAEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G07</accession>
    <name>Q32G07_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yneB</name>
        <name evidence="1" type="ordered locus">SDY_1623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378689.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403239.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G07"/>
    <dbReference type="STRING" id="300267.SDY_1623"/>
    <dbReference type="EnsemblBacteria" id="ABB61748">
        <property type="protein sequence ID" value="ABB61748"/>
        <property type="gene ID" value="SDY_1623"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1623"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1955"/>
    <dbReference type="HOGENOM" id="CLU_057069_1_0_6"/>
    <dbReference type="OMA" id="CEYWGMP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="270" mass="29645" checksum="112B2CEDA6664477" modified="2005-12-06" version="1">MKNTCSTNWKHHRGMQSRLSRIFNPKTGKTVMLAFDHGYFQGPTTGLEHIDINIAPLFEHADVLMCTRGILRSVVPPATNRPVVLRASGANSILAELSNEAVALSMDDAVRLNSCAVAAQVYIGSEYEHQSIKNIIQLVDAGMKVGIPTMAVTGVGKDMVRDQRYFSLATRIAAEMGAQIIKTYYVEKGFERIVAGCPVPIVIAGGKKLPEREALEMCWQAIDQGASGVDMGRNIFQSDHPVAMMKAVQAVVHHNETADRAYELYLSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G11</accession>
    <name>Q32G11_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G11"/>
    <dbReference type="STRING" id="300267.SDY_1619"/>
    <dbReference type="EnsemblBacteria" id="ABB61744">
        <property type="protein sequence ID" value="ABB61744"/>
        <property type="gene ID" value="SDY_1619"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1619"/>
    <dbReference type="HOGENOM" id="CLU_2693501_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="9778" checksum="D6DBFEE7118C93F5" modified="2005-12-06" version="1">MGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G95</accession>
    <name>Q32G95_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ynjA</name>
        <name evidence="2" type="ordered locus">SDY_1523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000524067.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403151.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G95"/>
    <dbReference type="STRING" id="300267.SDY_1523"/>
    <dbReference type="EnsemblBacteria" id="ABB61660">
        <property type="protein sequence ID" value="ABB61660"/>
        <property type="gene ID" value="SDY_1523"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1523"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1823"/>
    <dbReference type="HOGENOM" id="CLU_082760_7_2_6"/>
    <dbReference type="OMA" id="RELAVYW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="182" mass="20571" checksum="B66D7D6089366066" modified="2005-12-06" version="1">MGLPPLSKIPFILRPQAWLHRRHYGEVLSPIRWWGRIPFIFYLVSMFVGWLERKRSPLDPVVQSLVSARIAQMCLCEFCMDITSMKVAERTGSSDKLLAVADWRQSPLFSDEERLALEYAEAASVTPPTVDDALRTRLAAHFDAQALTELTALIGLQNLSARFNSAMDIPAQGLCRIPEKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GB9</accession>
    <name>Q32GB9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GB9"/>
    <dbReference type="STRING" id="300267.SDY_1497"/>
    <dbReference type="EnsemblBacteria" id="ABB61636">
        <property type="protein sequence ID" value="ABB61636"/>
        <property type="gene ID" value="SDY_1497"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1497"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_4_6"/>
    <dbReference type="OMA" id="NDIANER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="2"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="205" mass="23125" checksum="FEC673829865F4A1" modified="2005-12-06" version="1">MQRLGIDYIDIYMTHWQSVPPFFTPIAETVAVLNELKAEGKIRAIGAANVDADHIREYLQYGELDIIQAKYSILDRAMENELLPLCRDNGIVVQVYSPLEQGLLTGTITRDYVPGGARANKVWFQRENMLKVIDMLEQWQLLCARYQCTIPTLALAWILKQSDLISILSGATAPEQVRENVAALNINLSDADATLMREMAEALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GE5</accession>
    <name>Q32GE5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403101.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GE5"/>
    <dbReference type="EnsemblBacteria" id="ABB61610">
        <property type="protein sequence ID" value="ABB61610"/>
        <property type="gene ID" value="SDY_1471"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1471"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1752"/>
    <dbReference type="HOGENOM" id="CLU_105355_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024497">
        <property type="entry name" value="DUF2773"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10971">
        <property type="entry name" value="DUF2773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="185" mass="21395" checksum="CD9069170D1604E8" modified="2005-12-06" version="1">MLLNATSLIRSDDWDFLESALISWDNLPAVVLKELQQNTPRNDIWAKFFLRQENSSRAQVNEALRVYYALDPDALAQLDVLAKQPDRIWWSTLAKSNLTFFKFGALNNRHTPPAVLAAEIDPEWWIVAMNNPRFPVDVLKARLKRDPLLSLELVNPELDLVRQLALNGKTRAIREQAMRKLDELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GI5</accession>
    <name>Q32GI5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403061.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GI5"/>
    <dbReference type="STRING" id="300267.SDY_1427"/>
    <dbReference type="EnsemblBacteria" id="ABB61570">
        <property type="protein sequence ID" value="ABB61570"/>
        <property type="gene ID" value="SDY_1427"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1427"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1698"/>
    <dbReference type="HOGENOM" id="CLU_176101_2_0_6"/>
    <dbReference type="OMA" id="MGARWNA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="79" mass="9119" checksum="2828394127F6AF4D" modified="2005-12-06" version="1">MPVHLTRWNAAVKRAGIRRRNPYHTRHTFACWLLTAGANPAFIASQMGHETAQMVYEIYGMWIDDMNDEQIAMLNARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GP8</accession>
    <name>Q32GP8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DEOR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001088621.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402998.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GP8"/>
    <dbReference type="STRING" id="300267.SDY_1361"/>
    <dbReference type="EnsemblBacteria" id="ABB61507">
        <property type="protein sequence ID" value="ABB61507"/>
        <property type="gene ID" value="SDY_1361"/>
    </dbReference>
    <dbReference type="GeneID" id="66674891"/>
    <dbReference type="KEGG" id="sdy:SDY_1361"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1612"/>
    <dbReference type="HOGENOM" id="CLU_060699_0_1_6"/>
    <dbReference type="OMA" id="ANYNCDT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="249" mass="27589" checksum="EBB5740C9226E443" modified="2005-12-06" version="1">MNSRQQTILQMVIDQGQVSVTDLAKATGVSEVTIRQDLNTLEKLSYLRRAHGFAVSLDSDDVETRMMSNYTLKRELAEFAASLVQPGETIFIENGSSNALLARTLGEQKKNVTIITVSSYIAHLLKDAPCEVILLGGVYQKKSESMVGPLTRQCIQQVHFSKAFIGIDGWQPETGFTGRDMMRTDVVNAVLEKECEAIVLTDSSKFGAVHSYSIGPVERFNRVITDSKIRASDLMHLEHSKLTVHVVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GS8</accession>
    <name>Q32GS8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="14">IGPS</shortName>
                <ecNumber evidence="14">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="15">PRAI</shortName>
                <ecNumber evidence="15">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14 18" type="primary">trpC</name>
        <name evidence="15" type="synonym">trpF</name>
        <name evidence="18" type="ordered locus">SDY_1330</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the TrpC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the TrpF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the TrpF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="14"/>
    <dbReference type="EC" id="5.3.1.24" evidence="15"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000983874.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402968.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GS8"/>
    <dbReference type="STRING" id="300267.SDY_1330"/>
    <dbReference type="EnsemblBacteria" id="ABB61477">
        <property type="protein sequence ID" value="ABB61477"/>
        <property type="gene ID" value="SDY_1330"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1330"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1580"/>
    <dbReference type="HOGENOM" id="CLU_007713_0_0_6"/>
    <dbReference type="OMA" id="YDIIGIN"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="15 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="16">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PRAI" evidence="17">
        <location>
            <begin position="258"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB61477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="453" mass="49461" checksum="01B11C2EF4CEC0AE" modified="2005-12-06" version="1">MMQTVLAKIVADKAIWVEARKQQQPLASFQNEVQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIATVYRNYASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAVAHSLEMGVLTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFTNGFLIGSALMAHDDLHAAVRRVLLGENKVCGLTRGQDAKAAYDAGAIYGGLILVATSPRCVNVEQAQEVMAAAPLQYVGVFRNHDIADVVDKAKVLSLAAVQLHGNEDQLYIDTLREALPAHVAIWKALSVGETLPARELQHVDKYVLDNGQGGSGQRFDWSLLNGQSLGNVLLAGGLGADNCVEAAQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GV2</accession>
    <name>Q32GV2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0263 protein YciU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yciU</name>
        <name evidence="2" type="ordered locus">SDY_1306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0263 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GV2"/>
    <dbReference type="STRING" id="300267.SDY_1306"/>
    <dbReference type="EnsemblBacteria" id="ABB61453">
        <property type="protein sequence ID" value="ABB61453"/>
        <property type="gene ID" value="SDY_1306"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1306"/>
    <dbReference type="HOGENOM" id="CLU_143392_0_0_6"/>
    <dbReference type="OMA" id="QFEDRGA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00680">
        <property type="entry name" value="UPF0263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007376">
        <property type="entry name" value="dsDNA_mimic_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036763">
        <property type="entry name" value="Put_dsDNA_mimic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04269">
        <property type="entry name" value="DUF440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004916">
        <property type="entry name" value="UCP004916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102816">
        <property type="entry name" value="SSF102816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="15462" checksum="940D728F0A53AB02" modified="2005-12-06" version="1">MSPSDCFTSSARCCKTSPTEVKQVVTMDMDLNNRLTEDETLEQAYDIFLELAADNLDPADVLLFNLQFEERGGAELFDPAEDWQEHVDFDLNPDFFAEVVIGLADSEDGEINDVFARILLCREKDHKLCHIIWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H02</accession>
    <name>Q32H02_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ychH</name>
        <name evidence="2" type="ordered locus">SDY_1254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000823887.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402894.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H02"/>
    <dbReference type="STRING" id="300267.SDY_1254"/>
    <dbReference type="EnsemblBacteria" id="ABB61403">
        <property type="protein sequence ID" value="ABB61403"/>
        <property type="gene ID" value="SDY_1254"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1254"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1491"/>
    <dbReference type="HOGENOM" id="CLU_187796_0_0_6"/>
    <dbReference type="OMA" id="KRCRRDQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019698">
        <property type="entry name" value="DUF2583"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10762">
        <property type="entry name" value="DUF2583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="92" mass="10456" checksum="7F6C2D4F0C7241C1" modified="2005-12-06" version="1">MKRKNASLLGNVLMGLGLVVMVVGVGYSILNQLPQFNTPQYFAHGAVLSIFVGAILWLAGARVGGHEQVCDRYWWVRHYDKRCRRSDNRRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H81</accession>
    <name>Q32H81_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000599619.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402815.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H81"/>
    <dbReference type="STRING" id="300267.SDY_1167"/>
    <dbReference type="EnsemblBacteria" id="ABB61324">
        <property type="protein sequence ID" value="ABB61324"/>
        <property type="gene ID" value="SDY_1167"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1167"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1375"/>
    <dbReference type="HOGENOM" id="CLU_168881_0_0_6"/>
    <dbReference type="OMA" id="PQWPEAN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="115" mass="13162" checksum="281EE138D74C8AE8" modified="2005-12-06" version="1">MILDSRPVHAARPHSEAIRDAQRKKPKVPVHAVLTATNPLIRFISSDDMTQNRELFQVWLQKLAQWHQTTTPYLFLHTPDIAQAPELVHTLWEDLRKTLPEIGAVPAIPQQSSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HF6</accession>
    <name>Q32HF6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yedE</name>
        <name evidence="9" type="ordered locus">SDY_1086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000118917.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402740.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HF6"/>
    <dbReference type="STRING" id="300267.SDY_1086"/>
    <dbReference type="EnsemblBacteria" id="ABB61249">
        <property type="protein sequence ID" value="ABB61249"/>
        <property type="gene ID" value="SDY_1086"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1086"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1276"/>
    <dbReference type="HOGENOM" id="CLU_041737_0_0_6"/>
    <dbReference type="OMA" id="FFTGIPM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="237"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="401" mass="44460" checksum="59E1518A94636E33" modified="2005-12-06" version="1">MSWQQFKHAWLIKFWAPIPAVIAAGILSTYYFGITGTFWAVTGEFTRWGGQLLQLFGVHAEEWGYFKIIHLEGSPLTRIDGMMILGMFGSCFAAALWANNVKLRMPRSRIRIMQAIIGGIIAGFGARLAMGCNLAAFFTGIPQFSLHAWFFAIATAIGSWFGARFTLLPIFRIPVKMQKVSAASPLTQKPDQARRRFRLGMLVFFGMLGWALLTAMNQPKLGLAMLFGVGFGLLIERAQICFTSAFRDMWITGRTHMAKAIIIGMAVSAIGIFSYVQLGVEPKIMWAGPNAVIGGLLFGFGIVLAGGCETGWMYRAVEGQVHYWWVGLGNVIGSTILAYYWDDFAPALATDWDKINLLKTFGPMGGLLVTYLLLFAALMLIIGWETRFFRRAAPQTVKEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HG5</accession>
    <name>Q32HG5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intimin/invasin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402731.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HG5"/>
    <dbReference type="STRING" id="300267.SDY_1077"/>
    <dbReference type="EnsemblBacteria" id="ABB61240">
        <property type="protein sequence ID" value="ABB61240"/>
        <property type="gene ID" value="SDY_1077"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1077"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1265"/>
    <dbReference type="HOGENOM" id="CLU_1516926_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003344">
        <property type="entry name" value="Big_1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02369">
        <property type="entry name" value="Big_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00634">
        <property type="entry name" value="BID_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51127">
        <property type="entry name" value="BIG1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big-1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="2">
        <location>
            <begin position="115"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="177" mass="18643" checksum="53165DDEDC78A4CE" modified="2005-12-06" version="1">MKQTLIVSFVGDSSTAQVDLQKSKNEVVADGNDSATMTATVRDTKGNLLNDVKVTFNVNSAAAKLSQTEVNSHDGIATATLTSLKNGDYTVTASVSSGSQANQQVIFIGDQSTAALTLSVPSGDITVTNTAPLHMTATLQDKNGNPLKDKEITFSVPNDVASRFLDLPLYFQTSVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HM6</accession>
    <name>Q32HM6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the antirestriction protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402670.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HM6"/>
    <dbReference type="SMR" id="Q32HM6"/>
    <dbReference type="STRING" id="300267.SDY_1014"/>
    <dbReference type="EnsemblBacteria" id="ABB61179">
        <property type="protein sequence ID" value="ABB61179"/>
        <property type="gene ID" value="SDY_1014"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1014"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1182"/>
    <dbReference type="HOGENOM" id="CLU_085306_1_0_6"/>
    <dbReference type="OMA" id="MGNGRNA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004914">
        <property type="entry name" value="Antirestrict"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042297">
        <property type="entry name" value="Antirestriction_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03230">
        <property type="entry name" value="Antirestrict"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="181" mass="20628" checksum="BEC2CC190F9896BA" modified="2005-12-06" version="1">MMNVMLPAPDLYSLSFIHITRISYMKTLSQNTTSSACAPETGLQQLVATIVPDEQRISFWPQHFGLIPQWVTLEPRVFGWMDRLCENYCGGIWNLYTLNNGGAFMAPEPDDDDDETWVLFNAMNGNRAEMSPEAAGIAACLMTYSHHACRTECYAMTVHYYRLRDYALQHPECSAIMRIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HZ3</accession>
    <name>Q32HZ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrate/nitrite response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">narP</name>
        <name evidence="5" type="ordered locus">SDY_0885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001113637.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402553.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HZ3"/>
    <dbReference type="SMR" id="Q32HZ3"/>
    <dbReference type="STRING" id="300267.SDY_0885"/>
    <dbReference type="EnsemblBacteria" id="ABB61062">
        <property type="protein sequence ID" value="ABB61062"/>
        <property type="gene ID" value="SDY_0885"/>
    </dbReference>
    <dbReference type="GeneID" id="66673912"/>
    <dbReference type="KEGG" id="sdy:SDY_0885"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1020"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_6"/>
    <dbReference type="OMA" id="LDRFAPM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="215" mass="23635" checksum="321B7A1186131C59" modified="2005-12-06" version="1">MPEATPFQVMIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQRGAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I01</accession>
    <name>CCMA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytochrome c biogenesis ATP-binding export protein CcmA</fullName>
            <ecNumber evidence="1">7.6.2.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heme exporter protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ccmA</name>
        <name type="ordered locus">SDY_0877</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB61054" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="7.6.2.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61054.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402545.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I01"/>
    <dbReference type="SMR" id="Q32I01"/>
    <dbReference type="STRING" id="300267.SDY_0877"/>
    <dbReference type="EnsemblBacteria" id="ABB61054">
        <property type="protein sequence ID" value="ABB61054"/>
        <property type="gene ID" value="SDY_0877"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0877"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1012"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015439">
        <property type="term" value="F:ABC-type heme transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005895">
        <property type="entry name" value="ABC_transptr_haem_export_CcmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43499">
        <property type="entry name" value="PTHR43499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01189">
        <property type="entry name" value="ccmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51243">
        <property type="entry name" value="CCMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000271960" description="Cytochrome c biogenesis ATP-binding export protein CcmA">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="207" mass="23139" checksum="5991F3F582590DF5" modified="2007-01-09" version="2">MGMLEVRELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTMLLRLLTGLSRPDAGEVLWQGQPLHQVRDSYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I71</accession>
    <name>Q32I71_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I71"/>
    <dbReference type="EnsemblBacteria" id="ABB60986">
        <property type="protein sequence ID" value="ABB60986"/>
        <property type="gene ID" value="SDY_0804"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0804"/>
    <dbReference type="HOGENOM" id="CLU_142885_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="109" mass="11970" checksum="EF15C40635E82358" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITTLSILTVIPFSSRGIASFIFIEITFSCLDCPVLIVILISFALISEISLTNFLNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IA8</accession>
    <name>Q32IA8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402438.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IA8"/>
    <dbReference type="STRING" id="300267.SDY_0765"/>
    <dbReference type="EnsemblBacteria" id="ABB60949">
        <property type="protein sequence ID" value="ABB60949"/>
        <property type="gene ID" value="SDY_0765"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0765"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.879"/>
    <dbReference type="HOGENOM" id="CLU_044146_5_0_6"/>
    <dbReference type="OMA" id="VKYAFAM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="218" mass="24845" checksum="3A1E8542EFDDCD51" modified="2005-12-06" version="1">MSVKVIVTDMDGTFLNDAKTYNQPRFMAQYQELKKRGIEFVVASGNQYYQLISFFPELKDEISFVAENGALVYEHGKQLFHGELTRHESRIVIGELLKDKQLNFVACGLQSAYVSENAPEAFVALMAKHYHRLKPVKDYQEIDDILFKFSLNLPDEQIPLVIDKLHIALDGIMKPVTSGFGFIDLIIPGLHKANGISRLLKRWDLSYREVTYLGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IC4</accession>
    <name>Q32IC4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000353913.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402422.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IC4"/>
    <dbReference type="STRING" id="300267.SDY_0749"/>
    <dbReference type="EnsemblBacteria" id="ABB60933">
        <property type="protein sequence ID" value="ABB60933"/>
        <property type="gene ID" value="SDY_0749"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0749"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.863"/>
    <dbReference type="HOGENOM" id="CLU_051638_10_2_6"/>
    <dbReference type="OMA" id="HMGIVIT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="183" mass="20765" checksum="C7112B4DD282A112" modified="2005-12-06" version="1">MDINELKECLHLEVIGKSRKFTWRKVIVRAMKHRRVRYLFWWRIAKYGHEKGGYWRKIAGKIERKILDSYDVKIPLVVDIGKGLDISYLTGVVIGHNVKIGENCSIKPGVTIGLRGHFDEMDIQIGNNVTIGCNASILGGKVYIGDNVTIGAHALVLHDIPENSIFINKIEYEIIPKKVIAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IG1</accession>
    <name>Q32IG1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">modB</name>
        <name evidence="13" type="ordered locus">SDY_0711</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000604034.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402385.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IG1"/>
    <dbReference type="SMR" id="Q32IG1"/>
    <dbReference type="STRING" id="300267.SDY_0711"/>
    <dbReference type="EnsemblBacteria" id="ABB60896">
        <property type="protein sequence ID" value="ABB60896"/>
        <property type="gene ID" value="SDY_0711"/>
    </dbReference>
    <dbReference type="GeneID" id="67413803"/>
    <dbReference type="KEGG" id="sdy:SDY_0711"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.822"/>
    <dbReference type="HOGENOM" id="CLU_016047_14_3_6"/>
    <dbReference type="OMA" id="MYSFIET"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="11"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB60896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="229" mass="24939" checksum="65A3A05FBF3382C6" modified="2005-12-06" version="1">MILTDPEWQAVLLSLKVSSLAVLFSLPFGIFFAWLLVRCTFPGKALLDSVLHLPLVLPPVVVGYLLLVSMGRRGFIGERLYDWFGITFAFSWRGAVLAAAVMSFPLMVRAIRLALEGVDVKLEQAARTLGAGRWRVFFTITLPLTLPGIIVGTVLAFARSLGEFGATITFVSNIPGETRTIPSAMYTLIQTPGGESGAARLCIISIALAMISLLISEWLARISRERAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32II2</accession>
    <name>Q32II2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tolA</name>
        <name evidence="3" type="ordered locus">SDY_0687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000030103.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402364.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32II2"/>
    <dbReference type="STRING" id="300267.SDY_0687"/>
    <dbReference type="EnsemblBacteria" id="ABB60875">
        <property type="protein sequence ID" value="ABB60875"/>
        <property type="gene ID" value="SDY_0687"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0687"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.801"/>
    <dbReference type="HOGENOM" id="CLU_035992_0_0_6"/>
    <dbReference type="OMA" id="FNLFRDI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019534">
        <property type="term" value="F:toxin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043213">
        <property type="term" value="P:bacteriocin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014161">
        <property type="entry name" value="Tol-Pal_TolA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06519">
        <property type="entry name" value="TolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02794">
        <property type="entry name" value="tolA_full"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="421" mass="43185" checksum="22024851A709EE9E" modified="2005-12-06" version="1">MSKAIEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQAEEAAAKAAADAKAKAEADAKAAEEAAKKAAADAKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAAEKAAADKKAAEKAAAEKAAADKKAAAEKAAADKKAAAAKAAAEKAAAAKAAAEADDIFGELSSGKNAPKTGGGAKGNNASLAGSGNTKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKIPKPPSQAVYEVFKNAPLDFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32II3</accession>
    <name>Q32II3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tol-Pal system protein TolR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">tolR</name>
        <name evidence="7" type="ordered locus">SDY_0686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000090097.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402363.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32II3"/>
    <dbReference type="SMR" id="Q32II3"/>
    <dbReference type="STRING" id="300267.SDY_0686"/>
    <dbReference type="EnsemblBacteria" id="ABB60874">
        <property type="protein sequence ID" value="ABB60874"/>
        <property type="gene ID" value="SDY_0686"/>
    </dbReference>
    <dbReference type="GeneID" id="66670992"/>
    <dbReference type="KEGG" id="sdy:SDY_0686"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.800"/>
    <dbReference type="HOGENOM" id="CLU_085305_1_3_6"/>
    <dbReference type="OMA" id="YITEKAM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02203">
        <property type="entry name" value="TolR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014168">
        <property type="entry name" value="Tol-Pal_TolR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02801">
        <property type="entry name" value="tolR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="142" mass="15383" checksum="936FE0033172600B" modified="2005-12-06" version="1">MARARGRGRRDLKSEINIVPLLDVLLVLLLIFMATAPIITQSVEVDLPDATESQAVSSNDNPPVIVEVSGIGQYTVVVEKDRLERLPPEQVVAEVSSRFKANPKTVFLIGGAKDVPYDEIIKALNLLHSAGVKSVGLMTQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32II7</accession>
    <name>Q32II7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative outer membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybgT</name>
        <name evidence="1" type="ordered locus">SDY_0682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000270282.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402359.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32II7"/>
    <dbReference type="SMR" id="Q32II7"/>
    <dbReference type="STRING" id="300267.SDY_0682"/>
    <dbReference type="EnsemblBacteria" id="ABB60870">
        <property type="protein sequence ID" value="ABB60870"/>
        <property type="gene ID" value="SDY_0682"/>
    </dbReference>
    <dbReference type="GeneID" id="66670996"/>
    <dbReference type="KEGG" id="sdy:SDY_0682"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.796"/>
    <dbReference type="HOGENOM" id="CLU_207013_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011724">
        <property type="entry name" value="Cyd_oper_YbgT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012994">
        <property type="entry name" value="YbgT_YccB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08173">
        <property type="entry name" value="YbgT_YccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02106">
        <property type="entry name" value="cyd_oper_ybgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="37" mass="4042" checksum="FCA4CC0A727F668B" modified="2005-12-06" version="1">MWYFAWILGTLLACSFGVITALALEHVESGKAGQEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IK2</accession>
    <name>Q32IK2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">sucD</name>
        <name evidence="7" type="ordered locus">SDY_0667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000025448.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402344.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IK2"/>
    <dbReference type="STRING" id="300267.SDY_0667"/>
    <dbReference type="EnsemblBacteria" id="ABB60855">
        <property type="protein sequence ID" value="ABB60855"/>
        <property type="gene ID" value="SDY_0667"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0667"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.778"/>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_6"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="289" mass="29805" checksum="98027AD829603C86" modified="2005-12-06" version="1">MSILIDKNTKVICQGFTGSQGTFHSEQAIAYGTKMVGGVTPGKGCTTHLGLPVFNTVREAVAATGATASVIYVPAPFCKDSILEAIDAGIKLIITITEGIPTLDMLTVKVKLDEAGVRMIGPNCPGVITPGECKIGIQPGHIHKPGKVGIVSRSGTLTYEAVKQTTDYGFGQSTCVGIGGDPIPGSNFIDILEMFEKDPQTEAIVMIGEIGGSAEEEAAAYIKEHVTKPVVGYIAGVTAPKGKRMGHAGAIIAGGKGTADEKFAALEAAGVKTVHSLADIGEALKTVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IN5</accession>
    <name>Q32IN5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of kdp operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdpE</name>
        <name evidence="5" type="ordered locus">SDY_0629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000186086.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402311.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IN5"/>
    <dbReference type="STRING" id="300267.SDY_0629"/>
    <dbReference type="EnsemblBacteria" id="ABB60822">
        <property type="protein sequence ID" value="ABB60822"/>
        <property type="gene ID" value="SDY_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0629"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.730"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_6"/>
    <dbReference type="OMA" id="MSHPGQL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="225" mass="25353" checksum="2C2FC78227B81E34" modified="2005-12-06" version="1">MTNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAVPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARMRVALRRHSATAAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAEKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDPARPSHFITETGIGYRFML</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IT9</accession>
    <name>SYL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="1">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuS</name>
        <name type="ordered locus">SDY_0564</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378592.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402257.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IT9"/>
    <dbReference type="SMR" id="Q32IT9"/>
    <dbReference type="STRING" id="300267.SDY_0564"/>
    <dbReference type="EnsemblBacteria" id="ABB60768">
        <property type="protein sequence ID" value="ABB60768"/>
        <property type="gene ID" value="SDY_0564"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0564"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.666"/>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_6"/>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000009431" description="Leucine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="619"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <sequence length="860" mass="97249" checksum="A2509286B6807783" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IV2</accession>
    <name>LIPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoyl synthase</fullName>
            <ecNumber evidence="1">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lip-syn</fullName>
            <shortName evidence="1">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lipA</name>
        <name type="ordered locus">SDY_0550</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000042632.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402244.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IV2"/>
    <dbReference type="SMR" id="Q32IV2"/>
    <dbReference type="STRING" id="300267.SDY_0550"/>
    <dbReference type="EnsemblBacteria" id="ABB60755">
        <property type="protein sequence ID" value="ABB60755"/>
        <property type="gene ID" value="SDY_0550"/>
    </dbReference>
    <dbReference type="GeneID" id="66671098"/>
    <dbReference type="KEGG" id="sdy:SDY_0550"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.651"/>
    <dbReference type="HOGENOM" id="CLU_033144_2_1_6"/>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000012283" description="Lipoyl synthase">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="80"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="321" mass="36072" checksum="BE7BF32A4E3AA358" modified="2005-12-06" version="1">MSKPIVMERGVKYRDADKMALIPVKNVATEREALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDANEPVKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIREKSPQIKIETLVPDFRGRMDRALDILTATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNEEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPDEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J26</accession>
    <name>PROB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl kinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proB</name>
        <name type="ordered locus">SDY_0474</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001285288.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402170.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J26"/>
    <dbReference type="SMR" id="Q32J26"/>
    <dbReference type="STRING" id="300267.SDY_0474"/>
    <dbReference type="EnsemblBacteria" id="ABB60681">
        <property type="protein sequence ID" value="ABB60681"/>
        <property type="gene ID" value="SDY_0474"/>
    </dbReference>
    <dbReference type="GeneID" id="66671440"/>
    <dbReference type="KEGG" id="sdy:SDY_0474"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.559"/>
    <dbReference type="HOGENOM" id="CLU_025400_2_0_6"/>
    <dbReference type="OMA" id="TVIHRDN"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000230066" description="Glutamate 5-kinase">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="275"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="169"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="211"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <sequence length="367" mass="39057" checksum="5541040202EBCCE8" modified="2005-12-06" version="1">MSDSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHVGQMLLTRADMEDRERFLNARDTLRALLDNNIVPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLTDQKGLYTADPRSNPQAELIKDVYGIDDALRAIAGDSVSGLGTGGMSTKLQAADVACRAGIDTIIAAGSKPGVIGDVMEGISVGTLFHAQATPLENRKRWIFGAPPAGEITVDEGATAAILERGSSLLPKGIKSVTGNFSRGEVIRICNLEGRDIAHGVSRYNSDALRRIAGHHSQEIDAILGYEYGPVAVHRDDMITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J37</accession>
    <name>Q32J37_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402159.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J37"/>
    <dbReference type="STRING" id="300267.SDY_0462"/>
    <dbReference type="EnsemblBacteria" id="ABB60670">
        <property type="protein sequence ID" value="ABB60670"/>
        <property type="gene ID" value="SDY_0462"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0462"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.545"/>
    <dbReference type="HOGENOM" id="CLU_186737_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7287" checksum="C92DC987237A9A7D" modified="2005-12-06" version="1">MRTRHLVGLISGVLILSVLLPVGLSIWLAHQQVETSFIEELDTYSSRVAIRANKVATQGKDALQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J99</accession>
    <name>Q32J99_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybbU</name>
        <name evidence="5" type="ordered locus">SDY_0396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000141271.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402097.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J99"/>
    <dbReference type="STRING" id="300267.SDY_0396"/>
    <dbReference type="EnsemblBacteria" id="ABB60608">
        <property type="protein sequence ID" value="ABB60608"/>
        <property type="gene ID" value="SDY_0396"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0396"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.470"/>
    <dbReference type="HOGENOM" id="CLU_062618_7_1_6"/>
    <dbReference type="OMA" id="DTTETIH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="271" mass="29304" checksum="17C55344C0F55086" modified="2005-12-06" version="1">MTEVRRRGRPGQAEPVAQKGAQALERGIAILQYLEKSGGSSSVSDISLNLDLPLSTTFRLLKVLQAADFVYQDSQLGWWHIGLGVFNVGAAYIHNRDVLSVAGPFMRRLMLLSGETVNVAIRNGNEAVLIGQLECKSMVRMCAPLGSRLPLHASGAGKALLYPLAEEELMSIILQTGLQQFTPTTFVDMPTLLKDLEQARELGYTVDKEEHVVGLNCIASAIYDDVGSVVAAISISGPSSRLTEDRFVSQGELVRDTARDISTALGLKAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JK3</accession>
    <name>Q32JK3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybaE</name>
        <name evidence="3" type="ordered locus">SDY_0285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JK3"/>
    <dbReference type="STRING" id="300267.SDY_0285"/>
    <dbReference type="EnsemblBacteria" id="ABB60504">
        <property type="protein sequence ID" value="ABB60504"/>
        <property type="gene ID" value="SDY_0285"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0285"/>
    <dbReference type="HOGENOM" id="CLU_017028_12_2_6"/>
    <dbReference type="OMA" id="EYWITPQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025370">
        <property type="entry name" value="SgrR_HTH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12793">
        <property type="entry name" value="SgrR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SgrR_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="123"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="431" mass="49341" checksum="45E3F61A2E80DA39" modified="2005-12-06" version="1">MRQAQEAGWLEWQAQSGRGKRGQLRFLVTPESLRNAMMEKALETGKQQDVLELAQLAPSELRTLLQPFMGGQWQNDTPTLRIPYYRPLEPLQPGFLPGRAEQHLAGQIFSGLTRFDNNTQHPIGDLAHHWETSADGLRWDFYLRSTLHWHNGDAVKASHLHQRLLMLLQLPALDQLFISVKRIEVTHPQCLTFFLHRPDYWLAHRLASYCSHLAHPQFPLIGTGPFRLTQFTAELVRLESHDYYHLRHPLLKAVEYWITPPLFEKDLGTSCRHPVQITIGKPEELQRVSQVSSGISLGFCYLTLRKSPRLSLWQARKVISIIHQSGLLQTLEVGENLITASHALLPGWTIPQWQVPDKVKLPKTLTLVYHLPIELHTMAERLQATLAAEGCELTIIFHNAKNWDDTTLLAHADLMMGDRLIGEAPEYTLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JQ9</accession>
    <name>Q32JQ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yaeE</name>
        <name evidence="8" type="ordered locus">SDY_0217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001294603.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401937.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JQ9"/>
    <dbReference type="STRING" id="300267.SDY_0217"/>
    <dbReference type="EnsemblBacteria" id="ABB60448">
        <property type="protein sequence ID" value="ABB60448"/>
        <property type="gene ID" value="SDY_0217"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0217"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.251"/>
    <dbReference type="HOGENOM" id="CLU_077375_0_1_6"/>
    <dbReference type="OMA" id="TFWSAIF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="13"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="217" mass="23258" checksum="EC1A36C372504AA8" modified="2005-12-06" version="1">MSEPMMWLLVRGVWETLAMTFVSGFFGFVIGLPVGVLLYVTRPGQIIANAKLYRTVSAIVNIFRSIPFIILLVWMIPFTRVIVGTSIGLQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLVSYSAMGGAVGAGGLGQIGYQYGYIGYNATVMNTVLVLLVILVYLIQFAGDRIVQAVTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JY0</accession>
    <name>Q32JY0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator for pyruvate dehydrogenase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdhR</name>
        <name evidence="5" type="ordered locus">SDY_0143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000331775.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401866.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JY0"/>
    <dbReference type="STRING" id="300267.SDY_0143"/>
    <dbReference type="EnsemblBacteria" id="ABB60377">
        <property type="protein sequence ID" value="ABB60377"/>
        <property type="gene ID" value="SDY_0143"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0143"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.161"/>
    <dbReference type="HOGENOM" id="CLU_017584_9_5_6"/>
    <dbReference type="OMA" id="EWPVGSR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="254" mass="29372" checksum="AF2031483D3F751D" modified="2005-12-06" version="1">MAYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSFSDPLVELLSDHPESQYDLLETRHALEGIAAYYAALRSTDEDKERIRELHHAIELAQQSGDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQNVRQNFELLYSRREMLPLVSSHRTRIFEAIMAGKPEEAREASHRHLAFIEEILLDRSREESRRECSLRRLEQRKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K36</accession>
    <name>RAPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-associated protein RapA</fullName>
            <ecNumber evidence="1">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent helicase HepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rapA</name>
        <name type="ordered locus">SDY_0083</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family. RapA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001117038.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401810.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K36"/>
    <dbReference type="SMR" id="Q32K36"/>
    <dbReference type="STRING" id="300267.SDY_0083"/>
    <dbReference type="EnsemblBacteria" id="ABB60321">
        <property type="protein sequence ID" value="ABB60321"/>
        <property type="gene ID" value="SDY_0083"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0083"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.93"/>
    <dbReference type="HOGENOM" id="CLU_011520_0_0_6"/>
    <dbReference type="OMA" id="MSILERD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01821">
        <property type="entry name" value="Helicase_RapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023949">
        <property type="entry name" value="Helicase_RapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022737">
        <property type="entry name" value="RapA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040765">
        <property type="entry name" value="Tudor_1_RapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040766">
        <property type="entry name" value="Tudor_2_RapA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12137">
        <property type="entry name" value="RapA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18339">
        <property type="entry name" value="Tudor_1_RapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18337">
        <property type="entry name" value="Tudor_RapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000088393" description="RNA polymerase-associated protein RapA">
        <location>
            <begin position="1"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="164"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="490"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAH box">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01821"/>
        </source>
    </evidence>
    <sequence length="968" mass="109809" checksum="593C7AE3D8D63108" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K61</accession>
    <name>Q32K61_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carnitinyl-CoA dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.149</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Crotonobetainyl-CoA hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">caiD</name>
        <name evidence="4" type="ordered locus">SDY_0058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-carnitinyl-CoA = crotonobetainyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:28338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:60932"/>
            <dbReference type="ChEBI" id="CHEBI:60933"/>
            <dbReference type="EC" id="4.2.1.149"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine metabolism; carnitine metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.149" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401785.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K61"/>
    <dbReference type="STRING" id="300267.SDY_0058"/>
    <dbReference type="EnsemblBacteria" id="ABB60296">
        <property type="protein sequence ID" value="ABB60296"/>
        <property type="gene ID" value="SDY_0058"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0058"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.64"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_6"/>
    <dbReference type="OMA" id="AMEMIMT"/>
    <dbReference type="UniPathway" id="UPA00117"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01051">
        <property type="entry name" value="CaiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022852">
        <property type="entry name" value="Carnitinyl_CoA_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="297" mass="32298" checksum="92DE9004C25AA01A" modified="2005-12-06" version="1">MKRQGTTLPANNHALKQYAFFAGMLSSLKKQKWRKGMSESLHLTRNGSILEITLDRPKANAIDAKNSFEMGEVFLNFRDDPQLRVAIITSAGEKFFSAGWGLKAAAEGEAPDADFGPGGFAGLTEIFNLDKPVIAAVNGYAFGGGFELALAADFIVCADNASFALPEAKLGIVPDSGGVLRLPKILTPAIVNEMVMTGRRMGAEEALRWGIVNRVVSQAELMDNARELAQQLVNSAPLAIAALKEIYRTTSEMPVEEAYRYIRSGVLKHYPSVLHSEDAIEGPLAFAEKRDPVWKGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K74</accession>
    <name>RS20_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsT</name>
        <name type="ordered locus">SDY_0045</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001274021.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401772.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K74"/>
    <dbReference type="SMR" id="Q32K74"/>
    <dbReference type="STRING" id="300267.SDY_0045"/>
    <dbReference type="EnsemblBacteria" id="ABB60283">
        <property type="protein sequence ID" value="ABB60283"/>
        <property type="gene ID" value="SDY_0045"/>
    </dbReference>
    <dbReference type="GeneID" id="66671687"/>
    <dbReference type="KEGG" id="sdy:SDY_0045"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.49"/>
    <dbReference type="HOGENOM" id="CLU_160655_4_0_6"/>
    <dbReference type="OMA" id="GVIHKNA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000224988" description="30S ribosomal protein S20">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="87" mass="9684" checksum="F02154BE2D1E22D9" modified="2005-12-06" version="1">MANIKSAKKRAIQSEKARKHNASRRSMMRTFIKKVYAAIEAGDKAAAQKAFNEMQPIVDRQAAKGLIHKNKAARHKANLTAQINKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KA8</accession>
    <name>Q32KA8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yaaH</name>
        <name evidence="7" type="ordered locus">SDY_0010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000528547.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KA8"/>
    <dbReference type="STRING" id="300267.SDY_0010"/>
    <dbReference type="EnsemblBacteria" id="ABB60250">
        <property type="protein sequence ID" value="ABB60250"/>
        <property type="gene ID" value="SDY_0010"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0010"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.10"/>
    <dbReference type="HOGENOM" id="CLU_051062_3_0_6"/>
    <dbReference type="OMA" id="WKKGNTF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="188" mass="20119" checksum="F169F31761BAF785" modified="2005-12-06" version="1">MGNTKLANPAPLGLMGFGMTTILLNLHNVGYFALDGIILAMGIFYGGIAQIFAGLLEYKKGNTFGLTAFTSYGSFWMTLVAILLMPKLGLTDAPNAQFLGVYLGLWGVFTLFMFFSTLKGARVLQFVFFSLTVLFALLAIGNIAGNAAIIHFAGWIGLICGASAIYLAMGEVLNEQFGRTVLPIGESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q327C8</accession>
    <name>Q327C8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Acid phosphatase</fullName>
            <ecNumber evidence="4 7">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">phoN1</name>
        <name evidence="10" type="ordered locus">SDY_P067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Sd197</strain>
            <plasmid evidence="11">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class A bacterial acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4 7"/>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000828660.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406068.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327C8"/>
    <dbReference type="EnsemblBacteria" id="ABB64580">
        <property type="protein sequence ID" value="ABB64580"/>
        <property type="gene ID" value="SDY_P067"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P067"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5614"/>
    <dbReference type="HOGENOM" id="CLU_079861_0_0_6"/>
    <dbReference type="OMA" id="TPRWELA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03397">
        <property type="entry name" value="PAP2_acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001011">
        <property type="entry name" value="Acid_Pase_classA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018296">
        <property type="entry name" value="Acid_Pase_classA_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000897">
        <property type="entry name" value="Acid_Ptase_ClsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00483">
        <property type="entry name" value="BACPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01157">
        <property type="entry name" value="ACID_PHOSPH_CL_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220922" description="Acid phosphatase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="9">
        <location>
            <begin position="115"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="249" mass="27169" checksum="604FCE0C72FC1277" modified="2005-12-06" version="1">MKRQLFTLSIVGVFSLNTFASFPPGNDVTTKPDLYYLTNDNAIDSLALLPPPPQIGSIAFLNDQAMYEKGLLLRNTERGKLAAEDANLSSGGVANVFSAAFGSPITAKDSPELHKLLTNMIEDAGDLATRSAKEYYMRIRPFAFYGVSTCNTKEQDTLSRNGSYPSGHTSIGWATALVLSEINPARQDTILKRGYELGDSRVICGYHWQSDVDAARIVGSAIVATLHSNPVFQAQLQKAKDEFANNQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q327G1</accession>
    <name>Q327G1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406035.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327G1"/>
    <dbReference type="EnsemblBacteria" id="ABB64547">
        <property type="protein sequence ID" value="ABB64547"/>
        <property type="gene ID" value="SDY_P034"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P034"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5575"/>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_6"/>
    <dbReference type="OMA" id="RINAYLM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="375" mass="44408" checksum="9746FC5B71C79CF8" modified="2005-12-06" version="1">MFDQQRDGNLYKIWNRLCSGTWFPPPVLEKRIPKSNGKERILGIPTVSDRIAQGAIKLFMEEKLDPIFHADSYGYRPGKSAHDALKQCAIRCWRYSWILEVDISAFFDHVRHDLVLKALEHHGMPKWVILYCRRWMEAPMQSCENGEVITRTRGTPQGGVISPLLANLFLHYAFDLWMEREYRGVPFERYADDIVVHCSRMSDATRLKNRLSERFSEVGLVLNAGKTNTAYIDTFKRRNVATSFTFLGYDFKVRTLKNFKGERYRKCMPGASNAAMRKITETIKKWRIHRSTAESLLDFARRYNAIVRGWIEYYGKFWSRNFNYRLWSAMQSRLLKWMQSKYRLSNRKAQRKLTLVRKEDPKLFVHWYLLRASNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q327G4</accession>
    <name>Q327G4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">parA</name>
        <name evidence="3" type="ordered locus">SDY_P031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000200286.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406032.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327G4"/>
    <dbReference type="EnsemblBacteria" id="ABB64544">
        <property type="protein sequence ID" value="ABB64544"/>
        <property type="gene ID" value="SDY_P031"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P031"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5570"/>
    <dbReference type="HOGENOM" id="CLU_037612_9_2_6"/>
    <dbReference type="OMA" id="FFDMLYS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041250">
        <property type="entry name" value="HTH_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18607">
        <property type="entry name" value="HTH_54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_54" evidence="2">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="111"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="399" mass="44344" checksum="C557424B440EDF85" modified="2005-12-06" version="1">MTSFEQLSKVAQRADKMLLALTKQIQEQKQEFQADVFYQVYSKSAVAKLPKLTRASVDGAVGEMEAQGYQFEKRPAGTATKYALTIQNIIDIYAHRGIPKYRDRYSEAYSIFIGSLKGGVSKTVSSVSVAHALRAHPHLLSEDLRILLLDLDPQSSATMFLNYLHAVGLVDTTAPQAMLQNVSREELLEDFIVPSVIPGVYVMPASIDDAFIASNWDTLCEEHLLGQNKHAILRENIIDKLKHDFDFILIDTGPHLDAFLKNAIAAADIMFTPVPPAQVDFHSTLKYLARLPELVQIIEQDGCSCRLQANIGFMSKLANKSDHKYCHSLTKEIFGGDMLDVSMPRLDGFERSGESFDTVISANPVTYVGSGEALKNARMAAEAFAKAVFDRIEFIRANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q327H8</accession>
    <name>Q327H8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS91 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P018</name>
        <name evidence="3" type="ordered locus">SDY_P204</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
            <plasmid evidence="2">pSD1_197</plasmid>
            <plasmid evidence="2">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406018.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406205.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64531">
        <property type="protein sequence ID" value="ABB64531"/>
        <property type="gene ID" value="SDY_P018"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64717">
        <property type="protein sequence ID" value="ABB64717"/>
        <property type="gene ID" value="SDY_P204"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P018"/>
    <dbReference type="KEGG" id="sdy:SDY_P204"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5552"/>
    <dbReference type="HOGENOM" id="CLU_2071535_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007069">
        <property type="entry name" value="Transposase_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04986">
        <property type="entry name" value="Y2_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="133" mass="15379" checksum="759A64406ACA4F20" modified="2005-12-06" version="1">MRYGSLAGWRYSAFLMLPRFADIFQQGNRWLNWLEKQPVQMSRLEHYAGQDEIGLRYNSHRTKREENLVMSGDEFMERFSWHVADKGFRMVIRGPESGEAAITGRCGVRHNGDSEKNGEANHKERDVSAVTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Q0</accession>
    <name>Q327Q0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3343 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000666413.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405946.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Q0"/>
    <dbReference type="EnsemblBacteria" id="ABB64455">
        <property type="protein sequence ID" value="ABB64455"/>
        <property type="gene ID" value="SDY_4595"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4595"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5443"/>
    <dbReference type="HOGENOM" id="CLU_167443_4_0_6"/>
    <dbReference type="OMA" id="GCGLCIY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="85" mass="9554" checksum="3D08D6966B70E8E0" modified="2005-12-06" version="1">MKEYLFLFHSTVGVIQTRKALQAAGMTFRVSDIPRDLRGGCGLCIWLTCPPGEEIQWVIPGHTESVYCQQDGGWRCIAHYGISPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q327S3</accession>
    <name>Q327S3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dipeptide transport system permease protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dppB</name>
        <name evidence="9" type="ordered locus">SDY_4566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000938855.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405923.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327S3"/>
    <dbReference type="SMR" id="Q327S3"/>
    <dbReference type="STRING" id="300267.SDY_4566"/>
    <dbReference type="EnsemblBacteria" id="ABB64432">
        <property type="protein sequence ID" value="ABB64432"/>
        <property type="gene ID" value="SDY_4566"/>
    </dbReference>
    <dbReference type="GeneID" id="66672569"/>
    <dbReference type="KEGG" id="sdy:SDY_4566"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5404"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_6"/>
    <dbReference type="OMA" id="WPGMGTF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="96"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="339" mass="37497" checksum="B4B9D2965C365AD1" modified="2005-12-06" version="1">MLQFILRRLGLVIPTFIGITLLTFAFVHMIPGDPVMIMAGERGISPERHAQLLAELGLDKPMWQQYLHYIWGVMHGDLGISMKSRIPVWEEFVPRFQATLELGVCAMIFATAVGIPVGVLAAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHWNLTPVSGRVSDMVFLDDSNPLTGFMLIDTAIWGEDGNFIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTARAKGLTRMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQRRDYPVVQGGVLLVATMIILVNLLVDLLYGVVNPRIRHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q327T7</accession>
    <name>Q327T7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhjJ</name>
        <name evidence="6" type="ordered locus">SDY_4547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001163137.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405909.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327T7"/>
    <dbReference type="STRING" id="300267.SDY_4547"/>
    <dbReference type="EnsemblBacteria" id="ABB64418">
        <property type="protein sequence ID" value="ABB64418"/>
        <property type="gene ID" value="SDY_4547"/>
    </dbReference>
    <dbReference type="GeneID" id="58462380"/>
    <dbReference type="KEGG" id="sdy:SDY_4547"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5375"/>
    <dbReference type="HOGENOM" id="CLU_043932_0_0_6"/>
    <dbReference type="OMA" id="FWHVQQN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220930" evidence="3">
        <location>
            <begin position="25"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="46"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="201"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="498" mass="55499" checksum="41BAE476A83B4BA2" modified="2005-12-06" version="1">MQGTKIRLLAGGLLMMATAGYVQADALQPDPAWQQGTLSNGLQWQVLTTPQRPSDRVEIRLLVNTGSLAESTQQSGYSHAIPRIALTQSGGLDAAQARSLWQQGIDPKRPMPPVIVSYDTTLFNLSLPNNRNDLLKEALSYLANATGKLTITPETINHALQSQDMVATWPADTKEGWWRYRLKGSTLLGHDPADPLKQPVEAEKIKDFYQKWYTPDAMTLLVVGNVDARSVVDQINKTFGELKGKRETPAPVPTLSPLRAEAVSIMTDAVRQDRLSIMWDTPWQPIRESAALLRYWRADLAREALFWHVQQALSASNSKDIGLGFDCRVLYLRAQCAINIESPNDKLNSNLNLVARELAKVRDKGLPEEEFNALVAQKKLELQKLFAAYARADTDILMGQRMRSLQNQVVDIAPEQYQKLRQDFLNSLTVEMLNQDLRQQLSNDMALILLQPKGEPEFNMKALQAAWDQIMAPSTAAATTSVATDDVHPEVTDIPPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q328B4</accession>
    <name>Q328B4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Suppressor of inhibitory function of ChpB, PemI-like, autoregulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">chpS</name>
        <name evidence="3" type="ordered locus">SDY_4460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405832.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328B4"/>
    <dbReference type="STRING" id="300267.SDY_4460"/>
    <dbReference type="EnsemblBacteria" id="ABB64341">
        <property type="protein sequence ID" value="ABB64341"/>
        <property type="gene ID" value="SDY_4460"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4460"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5261"/>
    <dbReference type="HOGENOM" id="CLU_150554_2_2_6"/>
    <dbReference type="OMA" id="EQMHASV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="85" mass="9575" checksum="BB0CBEC36707C1B9" modified="2005-12-06" version="1">MQMRITIKRWGNSAGMVIPNVVMKELNLWPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGDEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q328L8</accession>
    <name>Q328L8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane permeability altering protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yiaZ</name>
        <name evidence="3" type="ordered locus">SDY_4346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hok/gef family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001135729.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405728.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328L8"/>
    <dbReference type="EnsemblBacteria" id="ABB64237">
        <property type="protein sequence ID" value="ABB64237"/>
        <property type="gene ID" value="SDY_4346"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4346"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5130"/>
    <dbReference type="HOGENOM" id="CLU_177638_2_2_6"/>
    <dbReference type="OMA" id="LACDIKQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000021">
        <property type="entry name" value="Hok/gef_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018084">
        <property type="entry name" value="Hok/gef_toxin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01848">
        <property type="entry name" value="HOK_GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00281">
        <property type="entry name" value="HOKGEFTOXIC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00556">
        <property type="entry name" value="HOK_GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU221113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="50" mass="5883" checksum="ADE01D728446C724" modified="2005-12-06" version="1">MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIEQGGYELAAFLACNLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q328P4</accession>
    <name>Q328P4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTS system, mannose-specific IID component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SDY_4316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328P4"/>
    <dbReference type="STRING" id="300267.SDY_4316"/>
    <dbReference type="EnsemblBacteria" id="ABB64211">
        <property type="protein sequence ID" value="ABB64211"/>
        <property type="gene ID" value="SDY_4316"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4316"/>
    <dbReference type="HOGENOM" id="CLU_060742_2_0_6"/>
    <dbReference type="OMA" id="GDSFFWH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004704">
        <property type="entry name" value="PTS_IID_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03613">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00828">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51108">
        <property type="entry name" value="PTS_EIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="238" mass="25647" checksum="53CD2D9F4C116809" modified="2005-12-06" version="1">MEQRKITRSDLVSMFLRSNLQQASFNFERIHGLGFCYDMIPAIKRLYPLKEDQVAALRRHLVFFNTTPAVCGPVIGVTAAMEEARANGAEIDDGTINGIKVGLMGPLAGVGDPLVWGTLRPITAALGASLALSGNILGPLLFFFIFNAVRLAMKWYGLQLGFRKGVNIVSDMGGNVLQKLTEGASILGLFVMGVLVTKWTSINVPLVVSQTHAADGSTVTMTVQNILDQLCPGLLRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q328R6</accession>
    <name>Q328R6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328R6"/>
    <dbReference type="STRING" id="300267.SDY_4291"/>
    <dbReference type="EnsemblBacteria" id="ABB64189">
        <property type="protein sequence ID" value="ABB64189"/>
        <property type="gene ID" value="SDY_4291"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4291"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_3_6"/>
    <dbReference type="OMA" id="SRAIRCS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="106"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="272" mass="31652" checksum="32F8ADEE5CECC2B7" modified="2005-12-06" version="1">MVTLCHVFGVHRSSYRYWKNRPEKPDGRRAVLRSQVLELHGISHGSAGARSIATMATRRGYQMGRWLAGRLMKELGLVSCQQPTHRYKRGGHEHVAIPNYLERQFAVTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKPGGVMFHSDQGSHYTSRQFRQLLWRYQIRQSMSRRGNCWDNSPMERFFRSLKNEWIPVVGYVSFSEAAHAITDYIVGYYSALRPHEYNGGLPPNESENRYWKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q328U7</accession>
    <name>Q328U7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaerobic ribonucleoside-triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nrdD</name>
        <name evidence="8" type="ordered locus">SDY_4257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000187783.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405649.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328U7"/>
    <dbReference type="STRING" id="300267.SDY_4257"/>
    <dbReference type="EnsemblBacteria" id="ABB64158">
        <property type="protein sequence ID" value="ABB64158"/>
        <property type="gene ID" value="SDY_4257"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4257"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5018"/>
    <dbReference type="HOGENOM" id="CLU_002707_2_0_6"/>
    <dbReference type="OMA" id="YSYDRVP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0556">Organic radical</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="7">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="5">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="712" mass="80085" checksum="93442366474BBC92" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q329H7</accession>
    <name>Q329H7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase</fullName>
            <shortName evidence="1">PRPn C-P lyase</shortName>
            <ecNumber evidence="1">4.7.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phnJ</name>
        <name evidence="2" type="ordered locus">SDY_4118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the breakage of the C-P bond in alpha-D-ribose 1-methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane</text>
            <dbReference type="Rhea" id="RHEA:34707"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16183"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:68686"/>
            <dbReference type="ChEBI" id="CHEBI:68687"/>
            <dbReference type="EC" id="4.7.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhnJ family.</text>
    </comment>
    <dbReference type="EC" id="4.7.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000002312.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405519.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329H7"/>
    <dbReference type="STRING" id="300267.SDY_4118"/>
    <dbReference type="EnsemblBacteria" id="ABB64028">
        <property type="protein sequence ID" value="ABB64028"/>
        <property type="gene ID" value="SDY_4118"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4118"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4842"/>
    <dbReference type="HOGENOM" id="CLU_063386_0_0_6"/>
    <dbReference type="OMA" id="MVYQVPI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098848">
        <property type="term" value="F:alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010306">
        <property type="entry name" value="PhnJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06007">
        <property type="entry name" value="PhnJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011468">
        <property type="entry name" value="PhnJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00379">
        <property type="entry name" value="Phosphonate_metabolism_(PhnJ)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="281" mass="31852" checksum="3F18132B5B3DCF09" modified="2005-12-06" version="1">MANLSGYNFAYLDEQTKRMSRRAILKAVAIPGYQVPFGGREMPMPYGWGTGGIQLTASVIGESDVLKVIDQGADDTTNAVSIRNFFKRVTGVNTTERTDDATVIQTRHRIPETPLTEDQIIIFQVPIPEPLRFIEPRETETRTMHALEEYGVMQVKLYEDIARFGHIATTYAYPVKVNGRYVMDPSPIPKFDNPKMDMMPTLQLFGTGREKRIYAVPPFTRVESLDFDDHPFTVQQWDEPCAICGSTHSYLDEVVLDDAGNRMFVCSDTDYCRQQSEAKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q329L1</accession>
    <name>Q329L1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-damage-inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dinD</name>
        <name evidence="2" type="ordered locus">SDY_4076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329L1"/>
    <dbReference type="STRING" id="300267.SDY_4076"/>
    <dbReference type="EnsemblBacteria" id="ABB63994">
        <property type="protein sequence ID" value="ABB63994"/>
        <property type="gene ID" value="SDY_4076"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4076"/>
    <dbReference type="HOGENOM" id="CLU_065349_0_0_6"/>
    <dbReference type="OMA" id="FMLTRYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003497">
        <property type="entry name" value="BRO_N_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02498">
        <property type="entry name" value="Bro-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bro-N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="278" mass="31779" checksum="72C1B45957246374" modified="2005-12-06" version="1">MEWAMNEHHQPFEEIRHYGTEGQEFWSARELAPLLDYRDWRNFQKVLARATQACEASNQAASDHFVETTKMVVLGSGAQRELEDVHLSRYACYLVVQNGDPAKPVIAAGQTYFAIQTRRQELADDEAFRQLREDEKRLFLRNELKEHNKQLVEAAQQAGVATAIDFAIFQNHGYRGLYGGLDQKAIHQRKGLKKSQKILDHMGSTELAANLFRATQTEEKLKRDGVNSKQQANTTHFDVGRKVRQTIQELGGTMPEELPTPQISIKQLENCVKITEKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q329S1</accession>
    <name>ATPB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit beta</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpD</name>
        <name type="ordered locus">SDY_4016</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000190496.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405425.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329S1"/>
    <dbReference type="SMR" id="Q329S1"/>
    <dbReference type="STRING" id="300267.SDY_4016"/>
    <dbReference type="EnsemblBacteria" id="ABB63934">
        <property type="protein sequence ID" value="ABB63934"/>
        <property type="gene ID" value="SDY_4016"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4016"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4729"/>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_6"/>
    <dbReference type="OMA" id="GFNMIMD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000254375" description="ATP synthase subunit beta">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="150"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <sequence length="460" mass="50267" checksum="55A48F7E3EDCB887" modified="2005-12-06" version="1">MATGKIVQVIGAVVDVEFPQDAVPRVYDALAVQNGNERLVLEVQQQLGGGIVRTIAMGSSDGLRRGLDVKDLEHPIEVPVGKATLGRIMNVLGEPVDMKGEIGEEERWAIHRAAPSYEELSNSQELLETGIKVIDLMCPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMTDSNVIDKVSLVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLLFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKTGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLSRQIASLGIYPAVDPLDSTSRQLDPLVVGQEHYDTARGVQSILQRYQELKDIIAILGMDELSEEDKLVVARARKIQRFLSQPFFVAEVFTGSPGKYVSLKDTIRGFKGIMEGEYDHLPEQAFYMVGSIEEAVEKAKKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q329S7</accession>
    <name>ATP6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpB</name>
        <name type="ordered locus">SDY_4010</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000135621.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405419.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329S7"/>
    <dbReference type="SMR" id="Q329S7"/>
    <dbReference type="STRING" id="300267.SDY_4010"/>
    <dbReference type="EnsemblBacteria" id="ABB63928">
        <property type="protein sequence ID" value="ABB63928"/>
        <property type="gene ID" value="SDY_4010"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4010"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4723"/>
    <dbReference type="HOGENOM" id="CLU_041018_1_0_6"/>
    <dbReference type="OMA" id="FTHAVRL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000362465" description="ATP synthase subunit a">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <sequence length="271" mass="30261" checksum="A69610AF35AB4CCC" modified="2005-12-06" version="1">MASENMTPQDYIGHHLNNLQLDLRTFSLVDPQNPPATFWTINIDSMFFSVGLGLLFLVLFRSVAKKATSGVPGKFQTAIELVIGFVNGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIAEHVLGLPALRVVPSADVNVTLSMALGVFILILFYSIKMKGIGGFTKELTLQPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q329V5</accession>
    <name>Q329V5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329V5"/>
    <dbReference type="EnsemblBacteria" id="ABB63900">
        <property type="protein sequence ID" value="ABB63900"/>
        <property type="gene ID" value="SDY_3972"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3972"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="YISIMGK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="31998" checksum="34FEC0502B2CB774" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKDSNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARILGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q329W4</accession>
    <name>Q329W4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ECA polysaccharide chain length modulation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">wzzE</name>
        <name evidence="8" type="ordered locus">SDY_3963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates the polysaccharide chain length of enterobacterial common antigen (ECA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Probably part of a complex composed of WzxE, WzyE and WzzE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WzzB/Cld/Rol family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405382.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329W4"/>
    <dbReference type="STRING" id="300267.SDY_3963"/>
    <dbReference type="EnsemblBacteria" id="ABB63891">
        <property type="protein sequence ID" value="ABB63891"/>
        <property type="gene ID" value="SDY_3963"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3963"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4675"/>
    <dbReference type="HOGENOM" id="CLU_060925_2_1_6"/>
    <dbReference type="OMA" id="GLCCTLW"/>
    <dbReference type="UniPathway" id="UPA00566"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009246">
        <property type="term" value="P:enterobacterial common antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02025">
        <property type="entry name" value="WzzE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032895">
        <property type="entry name" value="WzzE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="349" mass="39620" checksum="9EC0E5D534CAB1DD" modified="2005-12-06" version="1">MMTQPMPGKPAEDAENELDIRGLFRTLWAGKLWIIGMGLAFALIALAYTFFARQEWSSTAITDRPTVNMLGGYYSQQQFLRNLDVRSNMASADQPSVMDEAYKEFVMQLASWDTRREFWLQTDYYKQRMVGNSKADAALLDEMINNIQFIPGDFTRAVNDSVKLIAETAPDANNLLRQYVAFASQRAASHLNDELKGAWAARTIQMKAQVKRQEEVAKAIYDRRMNSIEQALKIAEQHNISRSATDVPAEELPDSEMFLLGRPMLQARLENLQAVGPAFDLDYDQNRAMLNTLNVGPTLDPRFQTYRYLRTPEEPVKRDSPRRAFLMIMWGIVGGLIGAGVALTRRCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A10</accession>
    <name>Q32A10_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA recombination protein RmuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yigN</name>
        <name evidence="7" type="ordered locus">SDY_3911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000347707.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405336.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A10"/>
    <dbReference type="STRING" id="300267.SDY_3911"/>
    <dbReference type="EnsemblBacteria" id="ABB63845">
        <property type="protein sequence ID" value="ABB63845"/>
        <property type="gene ID" value="SDY_3911"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3911"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4619"/>
    <dbReference type="HOGENOM" id="CLU_024057_0_1_6"/>
    <dbReference type="OMA" id="GDSKMQG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30563">
        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="475" mass="54704" checksum="D2BD2FD450945DC0" modified="2005-12-06" version="1">MDFSIMVYAVIALVGVAIGWLFASYQHAQQKAEQLAEREEMVAELSAAKQQITQSEHWRAECELLNNEVRSLQSINTSLEADLREVTTRMEAAQQHADDKIRQMINSEQRLSEQFENLANRIFEHSNRRVDEQNRQSLNSLLSPLREQLDGFRRQVQDSFGKEAQERHTLTHEIRNLQQLNAQMAQEAINLTRALKGDNKTQGNWGEVVLTRVLEASGLREGYEYETQVSIENDARSRMQPDVIVRLPQGKDVVIDAKMTLVAYERYFNAEDDCTRESALQEHIASVRNHIRLLGRKDYQQLPGLRTLDYVLMFIPVEPAFLLALDRQPELITEALKNNIMLVSPTTLLVALRTIANLWRYEHQSRNAQQIADRASKLYDKMRLFIDDMSAIGQSLDKAQDNYRQAMKKLSSGRGNVLAQAEAFRGLGVEIKREINPDLAEQAVSQDEEYRLRSVPEQPNDEAYQRDDEYNQQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A39</accession>
    <name>Q32A39_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">DNA-binding transcriptional regulator NtrC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein NR(I)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">glnG</name>
        <name evidence="10" type="synonym">ntrC</name>
        <name evidence="13" type="ordered locus">SDY_3875</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001188777.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405307.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A39"/>
    <dbReference type="SMR" id="Q32A39"/>
    <dbReference type="STRING" id="300267.SDY_3875"/>
    <dbReference type="EnsemblBacteria" id="ABB63816">
        <property type="protein sequence ID" value="ABB63816"/>
        <property type="gene ID" value="SDY_3875"/>
    </dbReference>
    <dbReference type="GeneID" id="66672226"/>
    <dbReference type="KEGG" id="sdy:SDY_3875"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4582"/>
    <dbReference type="HOGENOM" id="CLU_000445_0_1_6"/>
    <dbReference type="OMA" id="DWTGNIR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010114">
        <property type="entry name" value="Transcript_reg_NtrC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01818">
        <property type="entry name" value="ntrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="11">
        <location>
            <begin position="140"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="469" mass="52255" checksum="645F401D4A10EFA0" modified="2005-12-06" version="1">MQRGIVWVVDDDSSIRWVLERALAGAGLTCTTFENGAEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAISHYQEQQQPRNVQLNGPTTDIIGEAPAMQDVFRIIGRLSRSSISVLINGESGTGKELVAHALHRHSPRAKAPFIALNMAAIPKDLIESELFGHEKGAFTGANTIRQGRFEQADGGTLFLDEIGDMPLDVQTRLLRVLADGQFYRVGGYAPVKVDVRIIAATHQNLEQRVQEGKFREDLFHRLNVIRVHLPPLRERREDIPRLARHFLQVAARELGVEAKLLHPETEAALTRLAWPGNVRQLENTCRWLTVMAAGQEVLIQDLPGELFESTVAESTSQMQPDSWATLLAQWADRALRSGHQNLLSEAQPELERTLLTTALRHTQGHKQEAARLLGWGRNTLTRKLKELGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AA3</accession>
    <name>Q32AA3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="7">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="7">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">menA</name>
        <name evidence="8" type="ordered locus">SDY_3807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005015798.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405243.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AA3"/>
    <dbReference type="STRING" id="300267.SDY_3807"/>
    <dbReference type="EnsemblBacteria" id="ABB63752">
        <property type="protein sequence ID" value="ABB63752"/>
        <property type="gene ID" value="SDY_3807"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3807"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4497"/>
    <dbReference type="HOGENOM" id="CLU_043611_1_1_6"/>
    <dbReference type="OMA" id="QWIEGAR"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="308" mass="33568" checksum="2805195DF0BCB735" modified="2005-12-06" version="1">MTEQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGHFDPLVALLALITAGLLQILSNLANDYGDAVKGSDKPDRIGPLRGMQKGVITQQEMKRALIITVVLICLSGLALVAVACHTLADFVGFLILGGLSIIAATTYTVGNRPYGYIGLGDISVLVFFGWLSVMGSWYLQAHTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGEVNARRYHACLLMGSLVCLALFNLFSLHSLWGWLFLLAAPLLVKQARYVMREMDPVAMRPMLERTVKGALLTNLLFVVGIFLSQWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AC8</accession>
    <name>Q32AC8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoenolpyruvate--protein phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ptsA</name>
        <name evidence="13" type="ordered locus">SDY_3782</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405218.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AC8"/>
    <dbReference type="STRING" id="300267.SDY_3782"/>
    <dbReference type="EnsemblBacteria" id="ABB63727">
        <property type="protein sequence ID" value="ABB63727"/>
        <property type="gene ID" value="SDY_3782"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3782"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4472"/>
    <dbReference type="HOGENOM" id="CLU_007308_5_0_6"/>
    <dbReference type="OMA" id="QHIYGEQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="12">
        <location>
            <begin position="566"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="711" mass="78402" checksum="C2FEC0228B1AAA9A" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AD4</accession>
    <name>Q32AD4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional aspartokinase/homoserine dehydrogenase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Aspartokinase</fullName>
                <ecNumber evidence="16">2.7.2.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Homoserine dehydrogenase</fullName>
                <ecNumber evidence="16">1.1.1.3</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="primary">metL</name>
        <name evidence="20" type="ordered locus">SDY_3775</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 16">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 16">In the C-terminal section; belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 16">In the N-terminal section; belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="16"/>
    <dbReference type="EC" id="1.1.1.3" evidence="16"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000110793.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405212.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AD4"/>
    <dbReference type="STRING" id="300267.SDY_3775"/>
    <dbReference type="EnsemblBacteria" id="ABB63721">
        <property type="protein sequence ID" value="ABB63721"/>
        <property type="gene ID" value="SDY_3775"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3775"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4464"/>
    <dbReference type="HOGENOM" id="CLU_009116_7_2_6"/>
    <dbReference type="OMA" id="GAGVCKN"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04257">
        <property type="entry name" value="AAK_AK-HSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041743">
        <property type="entry name" value="AK-HSDH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_aspartokin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000727">
        <property type="entry name" value="ThrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 16" id="KW-0521">NADP</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="17">
        <location>
            <begin position="12"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_3" evidence="19">
        <location>
            <begin position="465"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine_dh" evidence="18">
        <location>
            <begin position="608"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00007952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00010046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ABB63721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="810" mass="89048" checksum="D9617E61C83A3E49" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AE9</accession>
    <name>Q32AE9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Biotin operon repressor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="7">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">birA</name>
        <name evidence="9" type="ordered locus">SDY_3755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000654618.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405197.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AE9"/>
    <dbReference type="SMR" id="Q32AE9"/>
    <dbReference type="STRING" id="300267.SDY_3755"/>
    <dbReference type="EnsemblBacteria" id="ABB63706">
        <property type="protein sequence ID" value="ABB63706"/>
        <property type="gene ID" value="SDY_3755"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3755"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4446"/>
    <dbReference type="HOGENOM" id="CLU_051096_4_0_6"/>
    <dbReference type="OMA" id="AVWKHIE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004409">
        <property type="entry name" value="Biotin_operon_repress_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00122">
        <property type="entry name" value="birA_repr_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0092">Biotin</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="8">
        <location>
            <begin position="66"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="7">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="7">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="321" mass="35329" checksum="E1C1BDDD39E2B68D" modified="2005-12-06" version="1">MKDNTVPLKLIALLANGEFHSGEQLGETLGMSRAAINKHIQTLRDWGVDVFTVPGKGYSLPEPIQLLNAEQILGQLDGGSVTVLPVIDSTNQYLLDRIGELKSGDACVAEYQQAGRGRRGRKWFSPFGANLYLSMFWRLEQGPAAAIGLSLVIGIVMAEVLRKLGADKVRVKWPNDLYLQDRKLAGILVELTGKTGDAAQIVIGAGINMAMRRVEESVVNQGWITLQEAGINLDRNTLAAMLIRELRAALELFEQEGLAPYLSRWEKLDNFINRPVKLIIGDKEIFGISRGIDKQGALLLEQDGIIKPWMGGEISLRSAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AK4</accession>
    <name>Q32AK4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yrfB</name>
        <name evidence="1" type="ordered locus">SDY_3686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405142.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AK4"/>
    <dbReference type="STRING" id="300267.SDY_3686"/>
    <dbReference type="EnsemblBacteria" id="ABB63651">
        <property type="protein sequence ID" value="ABB63651"/>
        <property type="gene ID" value="SDY_3686"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3686"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4373"/>
    <dbReference type="HOGENOM" id="CLU_117126_0_0_6"/>
    <dbReference type="OMA" id="WLARCGM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="126" mass="14610" checksum="47148C2835B202C5" modified="2005-12-06" version="1">MNMFFDWWFATSPRLRQLCWAVWLLMLVTLIFLSSTHHEESDALIRLRASHHQQWAALYRLVDTTPFSEEKTPPFSPLDFQLSGAQLVSWHPSAQGGELALKTLWEAVPSAFIRLAERNVSVSRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AV1</accession>
    <name>Q32AV1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UPF0056 inner membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yhgN</name>
        <name evidence="9" type="ordered locus">SDY_3580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell inner membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001002544.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405045.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AV1"/>
    <dbReference type="STRING" id="300267.SDY_3580"/>
    <dbReference type="EnsemblBacteria" id="ABB63554">
        <property type="protein sequence ID" value="ABB63554"/>
        <property type="gene ID" value="SDY_3580"/>
    </dbReference>
    <dbReference type="GeneID" id="66672682"/>
    <dbReference type="KEGG" id="sdy:SDY_3580"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4251"/>
    <dbReference type="HOGENOM" id="CLU_079909_1_1_6"/>
    <dbReference type="OMA" id="IRMIFPQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="197" mass="21490" checksum="C3A2B0223545B212" modified="2005-12-06" version="1">MNEIISAAVLLILIMDPLGNLPIFMSVLKHTEPKRRRAIMVRELLIALLVMLVFLFAGEKILAFLSLRAETVSISGGIILFLIAIKMIFPSASGNSSGLPAGEEPFIVPLAIPLVAGPTILATLMLLSHQYPNQMGHLVIALLLAWGGTFVILLQSSLFLRLLGEKGVNALERLMGLILVMMATQMFLDGIRMWMKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B36</accession>
    <name>RL22_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplV</name>
        <name type="ordered locus">SDY_3491</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000447529.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404960.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B36"/>
    <dbReference type="SMR" id="Q32B36"/>
    <dbReference type="STRING" id="300267.SDY_3491"/>
    <dbReference type="EnsemblBacteria" id="ABB63469">
        <property type="protein sequence ID" value="ABB63469"/>
        <property type="gene ID" value="SDY_3491"/>
    </dbReference>
    <dbReference type="GeneID" id="60373126"/>
    <dbReference type="GeneID" id="67415356"/>
    <dbReference type="KEGG" id="sdy:SDY_3491"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4144"/>
    <dbReference type="HOGENOM" id="CLU_083987_3_3_6"/>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="PRO" id="PR:Q32B36"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000243205" description="50S ribosomal protein L22">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <sequence length="110" mass="12226" checksum="F0E0C6982772277C" modified="2005-12-06" version="1">METIAKHRHARSSAQKVRLVADLIRGKKVSQALDILTYTNKKAAVLVKKVLESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIMPRAKGRADRILKRTSHITVVVSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B70</accession>
    <name>Q32B70_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yrdA</name>
        <name evidence="2" type="ordered locus">SDY_3456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B70"/>
    <dbReference type="STRING" id="300267.SDY_3456"/>
    <dbReference type="EnsemblBacteria" id="ABB63435">
        <property type="protein sequence ID" value="ABB63435"/>
        <property type="gene ID" value="SDY_3456"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3456"/>
    <dbReference type="HOGENOM" id="CLU_064827_1_0_6"/>
    <dbReference type="OMA" id="YVTIGHN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="256" mass="28374" checksum="9B7F1BE088E11552" modified="2005-12-06" version="1">MKCFTLSSQRRRIIGIPIFCTSIFLIFFSVCCFFTLFAAIAHKTVLFCILKDLHKANNAPKVISKSFIAEVSMSDVLRPYRDLFPQIGQRVMIDDSSVVIGDVRLADDVGIWPLVVIRGDVHYVQIGARTNIQDGSMLHVTHKSSYNPDGNPLTIGEDVTVGHKVMLHGCTIGNRVLVGMGSILLDGAIVEDDVMIGAGSLVPQNKRLESGYLYLGSPVKQIRPLSDEKKAGLRYSANNYVKWKDEYLDQGNQTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B75</accession>
    <name>Q32B75_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_1560</name>
        <name evidence="4" type="ordered locus">SDY_3441</name>
        <name evidence="5" type="ordered locus">SDY_3767</name>
        <name evidence="6" type="ordered locus">SDY_3812</name>
        <name evidence="7" type="ordered locus">SDY_3926</name>
        <name evidence="8" type="ordered locus">SDY_3927</name>
        <name evidence="9" type="ordered locus">SDY_4105</name>
        <name evidence="10" type="ordered locus">SDY_4107</name>
        <name evidence="11" type="ordered locus">SDY_4197</name>
    </gene>
    <organism evidence="4 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403187.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404921.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405205.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405248.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405351.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405352.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405509.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405510.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405593.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61696">
        <property type="protein sequence ID" value="ABB61696"/>
        <property type="gene ID" value="SDY_1560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63430">
        <property type="protein sequence ID" value="ABB63430"/>
        <property type="gene ID" value="SDY_3441"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63714">
        <property type="protein sequence ID" value="ABB63714"/>
        <property type="gene ID" value="SDY_3767"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63757">
        <property type="protein sequence ID" value="ABB63757"/>
        <property type="gene ID" value="SDY_3812"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63860">
        <property type="protein sequence ID" value="ABB63860"/>
        <property type="gene ID" value="SDY_3926"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63861">
        <property type="protein sequence ID" value="ABB63861"/>
        <property type="gene ID" value="SDY_3927"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64018">
        <property type="protein sequence ID" value="ABB64018"/>
        <property type="gene ID" value="SDY_4105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64019">
        <property type="protein sequence ID" value="ABB64019"/>
        <property type="gene ID" value="SDY_4107"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64102">
        <property type="protein sequence ID" value="ABB64102"/>
        <property type="gene ID" value="SDY_4197"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1560"/>
    <dbReference type="KEGG" id="sdy:SDY_3441"/>
    <dbReference type="KEGG" id="sdy:SDY_3767"/>
    <dbReference type="KEGG" id="sdy:SDY_3812"/>
    <dbReference type="KEGG" id="sdy:SDY_3926"/>
    <dbReference type="KEGG" id="sdy:SDY_3927"/>
    <dbReference type="KEGG" id="sdy:SDY_4105"/>
    <dbReference type="KEGG" id="sdy:SDY_4107"/>
    <dbReference type="KEGG" id="sdy:SDY_4197"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1870"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="HVISKQY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB64102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14902" checksum="6B08D4ED6C754B55" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKQYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B86</accession>
    <name>Q32B86_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B86"/>
    <dbReference type="EnsemblBacteria" id="ABB63420">
        <property type="protein sequence ID" value="ABB63420"/>
        <property type="gene ID" value="SDY_3430"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3430"/>
    <dbReference type="HOGENOM" id="CLU_217556_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="33" mass="4058" checksum="7CB4B9BCB66F1215" modified="2005-12-06" version="1">MVSRNHDFPVWMMLYNFMTKVFDESCPANRFSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BA9</accession>
    <name>RS9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsI</name>
        <name type="ordered locus">SDY_3406</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000829824.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404887.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BA9"/>
    <dbReference type="SMR" id="Q32BA9"/>
    <dbReference type="STRING" id="300267.SDY_3406"/>
    <dbReference type="EnsemblBacteria" id="ABB63396">
        <property type="protein sequence ID" value="ABB63396"/>
        <property type="gene ID" value="SDY_3406"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3406"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4064"/>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_6"/>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000051329" description="30S ribosomal protein S9">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <sequence length="130" mass="14886" checksum="607D563BD8812806" modified="2005-12-06" version="1">MAENQYYGTGRRKSSTARVFIKPGNGKIVINQRSLEQYFGRETARMVVRQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGITRALMEYDESLRSELRKAGFVTRDARQVERKKVGLRKARRRPQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BB1</accession>
    <name>Q32BB1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stringent starvation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sspB</name>
        <name evidence="2" type="ordered locus">SDY_3404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000366120.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404885.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BB1"/>
    <dbReference type="STRING" id="300267.SDY_3404"/>
    <dbReference type="EnsemblBacteria" id="ABB63394">
        <property type="protein sequence ID" value="ABB63394"/>
        <property type="gene ID" value="SDY_3404"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3404"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4062"/>
    <dbReference type="HOGENOM" id="CLU_118425_0_0_6"/>
    <dbReference type="OMA" id="FQARFGG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007481">
        <property type="entry name" value="SspB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036760">
        <property type="entry name" value="SspB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37486">
        <property type="entry name" value="PTHR37486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04386">
        <property type="entry name" value="SspB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005276">
        <property type="entry name" value="SspB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101738">
        <property type="entry name" value="SSF101738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="165" mass="18387" checksum="500313F430B22F19" modified="2005-12-06" version="1">MDLSQLTPRRPYLLRAFYEWLLDNQLTPHLVVDVTLLGVQVPMEYARDGQIVLNIAPRAVGNLELANDEVRFNARFGGIPRQVSVPLAAVLAIYARENGAGTMFEPEAAYDEDTSIMNDEEASADNETVMSVIDSDKPDHYDDTHPDDEPPQPPRGGRPTLRVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BC2</accession>
    <name>Q32BC2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yhcC</name>
        <name evidence="8" type="ordered locus">SDY_3392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018848.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404874.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BC2"/>
    <dbReference type="STRING" id="300267.SDY_3392"/>
    <dbReference type="EnsemblBacteria" id="ABB63383">
        <property type="protein sequence ID" value="ABB63383"/>
        <property type="gene ID" value="SDY_3392"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3392"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4046"/>
    <dbReference type="HOGENOM" id="CLU_060920_0_0_6"/>
    <dbReference type="OMA" id="NAGFTCP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005911">
        <property type="entry name" value="YhcC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF1">
        <property type="entry name" value="PTHR11135:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01091">
        <property type="entry name" value="uncharacterized_CHP01210-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01212">
        <property type="entry name" value="TIGR01212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="309" mass="34594" checksum="88D61BFBB769B4A6" modified="2005-12-06" version="1">MQLQKLVNMFGGDLTRRYGQKVHKLTLHGGFSCPNRDGTIGRGGCTFCNVASFADEAQQHRSIAEQLAHQANLVNRAKRYLAYFQAYTSTFAEVQVLRSMYQQAVSQANIVGLCVGTRPDCVPDAVLDLLCEYKDQGYEVWLELGLQTAHDKTLHRINRGHDFACYQRTTQLACQRGLKVCSHLIVGLPGEGQAECLQTLERVVETGVDGIKLHPLHIVKGSIMAKAWEAGRLNGIELEDYTLTAGEMIRHTPPEVIYHRISASARRPTLLAPLWCENRWTGMVELDRYLNEHGVQGSALGRPWLPHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BI8</accession>
    <name>Q32BI8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_2764</name>
        <name evidence="4" type="ordered locus">SDY_3323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404808.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62807">
        <property type="protein sequence ID" value="ABB62807"/>
        <property type="gene ID" value="SDY_2764"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63317">
        <property type="protein sequence ID" value="ABB63317"/>
        <property type="gene ID" value="SDY_3323"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2764"/>
    <dbReference type="KEGG" id="sdy:SDY_3323"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3976"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14914" checksum="F065607D71B49756" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARPGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BP8</accession>
    <name>Q32BP8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yqjH</name>
        <name evidence="2" type="ordered locus">SDY_3254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001065880.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404748.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BP8"/>
    <dbReference type="STRING" id="300267.SDY_3254"/>
    <dbReference type="EnsemblBacteria" id="ABB63257">
        <property type="protein sequence ID" value="ABB63257"/>
        <property type="gene ID" value="SDY_3254"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3254"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3888"/>
    <dbReference type="HOGENOM" id="CLU_040923_4_0_6"/>
    <dbReference type="OMA" id="VHAFVHG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="254" mass="28989" checksum="9BCC9A54AEA35281" modified="2005-12-06" version="1">MNNSPRYPQRVRNDLRFRELTVLRVEHISAGFQRIVLGGEALDGFTSRGFDDHSKLFFPQPDAHFVPPTVTEEGIVWPEGPRPPSRDYTPLYDELRHELAIDFFIHEDGVASSWAMQAQPGDKLTVAGPRGSLVVPEDYAYQLYVCDESGMPALRRRLETLSKLAVKPQVSALVSVRDNACQDYFAHLDGFNIEWLAHDEQAVDARLAQMQIPADDYFIWITGEGKVIKNLSRRFEAEQYDPQRVRAAAYWHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BT7</accession>
    <name>Q32BT7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqiA</name>
        <name evidence="1" type="ordered locus">SDY_3209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000105733.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404709.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BT7"/>
    <dbReference type="SMR" id="Q32BT7"/>
    <dbReference type="STRING" id="300267.SDY_3209"/>
    <dbReference type="ESTHER" id="shiss-yqia">
        <property type="family name" value="abh_upf00227"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63218">
        <property type="protein sequence ID" value="ABB63218"/>
        <property type="gene ID" value="SDY_3209"/>
    </dbReference>
    <dbReference type="GeneID" id="67415021"/>
    <dbReference type="KEGG" id="sdy:SDY_3209"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3834"/>
    <dbReference type="HOGENOM" id="CLU_090996_2_0_6"/>
    <dbReference type="OMA" id="MLAHYPG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008886">
        <property type="entry name" value="UPF0227/Esterase_YqiA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35602">
        <property type="entry name" value="PTHR35602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05728">
        <property type="entry name" value="UPF0227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="193" mass="21642" checksum="3077DED58BC0E8A3" modified="2005-12-06" version="1">MSTLLYLHGFNSSPRSAKASLLKNWLAEHHPDVEMIIPQLPPYPSDAAELLESIVLEHGGDSLGIVGSSLGGYYATWLSQCFMLPAVVVNPAVRPFELLTDYLGQNENPYTGQQYVLESRHIYDLKVMQIDPLEAPDLIWLLQQTGDEVLDYRQAVAYYASCRQTVIEGGNHAFTGFEDYFNPIVDFLGLHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BX4</accession>
    <name>Q32BX4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.399</ecNumber>
            <ecNumber evidence="7">1.1.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">serA</name>
        <name evidence="15" type="ordered locus">SDY_3169</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="6"/>
    <dbReference type="EC" id="1.1.1.95" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001151609.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404672.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BX4"/>
    <dbReference type="STRING" id="300267.SDY_3169"/>
    <dbReference type="EnsemblBacteria" id="ABB63181">
        <property type="protein sequence ID" value="ABB63181"/>
        <property type="gene ID" value="SDY_3169"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3169"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3787"/>
    <dbReference type="HOGENOM" id="CLU_019796_9_2_6"/>
    <dbReference type="OMA" id="YGNIGTQ"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="339"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB63181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="410" mass="44234" checksum="D32F583EF44F3032" modified="2005-12-06" version="1">MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGEKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BZ0</accession>
    <name>Q32BZ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000283196.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404656.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BZ0"/>
    <dbReference type="STRING" id="300267.SDY_3152"/>
    <dbReference type="EnsemblBacteria" id="ABB63165">
        <property type="protein sequence ID" value="ABB63165"/>
        <property type="gene ID" value="SDY_3152"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3152"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3764"/>
    <dbReference type="HOGENOM" id="CLU_1304147_0_0_6"/>
    <dbReference type="OMA" id="WAPKDSM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="235" mass="26897" checksum="42486083B057BA3E" modified="2005-12-06" version="1">MYPFTSLTRWALAACTTLILPAQTILPIYSAATFFCLIALKATRRRAKYVVWLMFSLGAGLWLVHGGWLTEWLSGTPRLPERWTHAITLWLRILAIVSTSQLWMQYIPVQCFIRALFASRLPPGVAYLFAGPLLVVEQLKRQLAIIHEAQRARGVPLDEGWYQRLRAMPALIIPLTHNALSDLAVRGAALDMRAFRIHNRRTTLWAPADSTLQRVARYTMILLMLTEFGAWIWLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C29</accession>
    <name>TRMB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmB</name>
        <name type="ordered locus">SDY_3112</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000786904.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404617.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C29"/>
    <dbReference type="SMR" id="Q32C29"/>
    <dbReference type="STRING" id="300267.SDY_3112"/>
    <dbReference type="EnsemblBacteria" id="ABB63126">
        <property type="protein sequence ID" value="ABB63126"/>
        <property type="gene ID" value="SDY_3112"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3112"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3721"/>
    <dbReference type="HOGENOM" id="CLU_050910_0_1_6"/>
    <dbReference type="OMA" id="PDPWHKS"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000229196" description="tRNA (guanine-N(7)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with RNA" evidence="2">
        <location>
            <begin position="150"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <sequence length="239" mass="27288" checksum="B4DD4F95FEE25FEB" modified="2005-12-06" version="1">MKNDVISPEFDENGRPLRRIRSFVRRQGRLTKGQEHALENYWPVMGVEFSEDMLDFPALFGREAPVTLEIGFGMGASLVAMAKDRPEQDFLGIEVHSPGVGACLASAHEEGLSNLHVMCHDAVEVLHKMIPDNSLRMVQLFFPDPWHKARHNKRRIVQVPFAELVKSKLQLGGVFHMATDWEPYAEHMLEVMSSIDGYKNLSESNDYVPRPASRPVTKFEQRGHRLGHGVWDLMFERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C33</accession>
    <name>Q32C33_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoside permease NupG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nupG</name>
        <name evidence="8" type="ordered locus">SDY_3108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404613.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C33"/>
    <dbReference type="STRING" id="300267.SDY_3108"/>
    <dbReference type="EnsemblBacteria" id="ABB63122">
        <property type="protein sequence ID" value="ABB63122"/>
        <property type="gene ID" value="SDY_3108"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3108"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3717"/>
    <dbReference type="HOGENOM" id="CLU_013133_1_2_6"/>
    <dbReference type="OMA" id="FMMMTNG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015506">
        <property type="term" value="F:nucleoside:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02049">
        <property type="entry name" value="NupG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004740">
        <property type="entry name" value="Nuc_H_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033667">
        <property type="entry name" value="NupG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03825">
        <property type="entry name" value="Nuc_H_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00889">
        <property type="entry name" value="2A0110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="225"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="434" mass="48279" checksum="889DCA58B51DF265" modified="2005-12-06" version="1">MCFFKHSSASRCEEINMNLKLQLKILSFLQFCLWGSWLTTLGSYMFVTLKFDGASIGAVYSSLGIAAVFMPALLGIVADKWLSAKWVYAICHTIGAITLFMAAQVTTPEAMFLVILINSFAYMPTLGLINTISYYRLQNAGMDIVTDFPPIRIWGTIGFIMAMWVVSLSGFELSHMQLYIGAALSAILVLFTLTLPHIPVAKQQANQSWTTLLGLDAFALFKNKRMAIFFIFSMLLGAELQITNMFGNTFLHSFDKDPMFASSFIVQHASIIMSISQISETLFILTIPFFLSRYGIKNVMMISIVAWILRFALFAYGDPTPFGTVLLVLSMIVYGCAFDFFNISGSVFVEKEVSPAIRASAQGMFLMMTNGFGCILGGIVSGKVVEMYTQNGITDWQTVWLIFAGYSVVLAFAFMAMFKYKHVRVPTGTQTVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C41</accession>
    <name>Q32C41_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type II secretion system protein I</fullName>
            <shortName evidence="6">T2SS minor pseudopilin I</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gspI</name>
        <name evidence="8" type="ordered locus">SDY_3098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Type II secretion is composed of four main components: the outer membrane complex, the inner membrane complex, the cytoplasmic secretion ATPase and the periplasm-spanning pseudopilus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cell inner membrane</location>
            <topology evidence="2 6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Cleaved by prepilin peptidase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the GSP I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000820136.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404605.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C41"/>
    <dbReference type="STRING" id="300267.SDY_3098"/>
    <dbReference type="EnsemblBacteria" id="ABB63114">
        <property type="protein sequence ID" value="ABB63114"/>
        <property type="gene ID" value="SDY_3098"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3098"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3707"/>
    <dbReference type="HOGENOM" id="CLU_121289_3_1_6"/>
    <dbReference type="OMA" id="RTWYWQQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003413">
        <property type="entry name" value="T2SS_GspI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010052">
        <property type="entry name" value="T2SS_protein-GspI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38779">
        <property type="entry name" value="PTHR38779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02501">
        <property type="entry name" value="T2SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01707">
        <property type="entry name" value="gspI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SSI" evidence="7">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="123" mass="13734" checksum="0A9583BB176B506C" modified="2005-12-06" version="1">MKRGFTLLEVMLALAIFALAATTVLQIASSALSNQHVLEEKTVAGWVAENQTALLYLMTREQRAVRHQGESDMAGNRWYWRTTPLNTGNALLQAVDIEVSRHEDFSSVIQSRRAWFSAVGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CB3</accession>
    <name>Q32CB3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Positive regulator of the fuc operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fucR</name>
        <name evidence="5" type="ordered locus">SDY_3023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378858.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404533.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CB3"/>
    <dbReference type="STRING" id="300267.SDY_3023"/>
    <dbReference type="EnsemblBacteria" id="ABB63042">
        <property type="protein sequence ID" value="ABB63042"/>
        <property type="gene ID" value="SDY_3023"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3023"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3629"/>
    <dbReference type="HOGENOM" id="CLU_060699_1_2_6"/>
    <dbReference type="OMA" id="YKHSMVA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="243" mass="27426" checksum="2C0B6FD2D4297241" modified="2005-12-06" version="1">MKAARQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSGDPFHIRLKSHYAHKADIAREALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICHELGKRERIQLFSSGGTLERKYGCYVNPSLISQLKSLEIDLFIFSCEGIDSSSALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQVATSLVTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CC5</accession>
    <name>SYDP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein Syd</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">syd</name>
        <name type="ordered locus">SDY_3010</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Syd family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000342443.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404521.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CC5"/>
    <dbReference type="SMR" id="Q32CC5"/>
    <dbReference type="STRING" id="300267.SDY_3010"/>
    <dbReference type="EnsemblBacteria" id="ABB63030">
        <property type="protein sequence ID" value="ABB63030"/>
        <property type="gene ID" value="SDY_3010"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3010"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3614"/>
    <dbReference type="HOGENOM" id="CLU_121866_0_0_6"/>
    <dbReference type="OMA" id="GIPSPCI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16323">
        <property type="entry name" value="Syd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01104">
        <property type="entry name" value="Syd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009948">
        <property type="entry name" value="Syd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038228">
        <property type="entry name" value="Syd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07348">
        <property type="entry name" value="Syd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000298266" description="Protein Syd">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01104"/>
        </source>
    </evidence>
    <sequence length="181" mass="20664" checksum="7D73BAC0C1123C5A" modified="2005-12-06" version="1">MDDLTAQALKEFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQSAIHTFYTTQFAGDIHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHLASNLAEFLNQLKPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CN7</accession>
    <name>Q32CN7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404409.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CN7"/>
    <dbReference type="STRING" id="300267.SDY_2883"/>
    <dbReference type="EnsemblBacteria" id="ABB62918">
        <property type="protein sequence ID" value="ABB62918"/>
        <property type="gene ID" value="SDY_2883"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2883"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3467"/>
    <dbReference type="HOGENOM" id="CLU_059923_1_0_6"/>
    <dbReference type="OMA" id="FVWNATN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="347" mass="40030" checksum="1163CDF736621AAD" modified="2005-12-06" version="1">MHHTPQDPEHHGEGDVGVHTEMVLNALVTLPEFQQLPAQQQEVLWAAALLHDVEKRSTTVQENGRIQSPGHARRGELTARLILWRDIPTPFVLREQIVALVRLHGLPLWLLERPEPERLLLTAAMRIDTGLLALLARADLLGHQSPDRQSMLERIDLFELFCQEQQCWGKVRSFVSDSARWHYLTHEQSSPDFVPWEAEPFEVILLCGLPGMSKDRYISKQCQGIDVISLDDMRRRINASPDDKTATGRIVQQAKEEARVFLRQKKPFIWNATNITRQLRSQLISLFTAYGARVKIVYLEVPWAQWKQQNARREYAVPEAVVMRMASRLEVPQPDEAHSVEYRVIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CS8</accession>
    <name>Q32CS8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Outer membrane protein assembly factor BamD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bamD</name>
        <name evidence="3" type="ordered locus">SDY_2838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BamD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000197688.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404368.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CS8"/>
    <dbReference type="STRING" id="300267.SDY_2838"/>
    <dbReference type="EnsemblBacteria" id="ABB62877">
        <property type="protein sequence ID" value="ABB62877"/>
        <property type="gene ID" value="SDY_2838"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2838"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3411"/>
    <dbReference type="HOGENOM" id="CLU_065982_0_2_6"/>
    <dbReference type="OMA" id="VERQHPY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15830">
        <property type="entry name" value="BamD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00922">
        <property type="entry name" value="OM_assembly_BamD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017689">
        <property type="entry name" value="BamD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03302">
        <property type="entry name" value="OM_YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019119" description="Outer membrane protein assembly factor BamD" evidence="1">
        <location>
            <begin position="24"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="2">
        <location>
            <begin position="28"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="245" mass="27828" checksum="91D88AFCEB248C49" modified="2005-12-06" version="1" precursor="true">MTRMKYLVAAATLSLFLAGCSGSKEEVPDNPPNEIYATAQQKLQDGNWRQAITQLEALDNRYPFGPYSQQVQLDLIYAYYKNADLPLAQAAIDRFIRLNPTHPNIDYVMYMRGLTNMALDDSALQGFFGVDRSDRDPQHARAAFSDFSKLVRGYPNSQYTTDATKRLVFLKDRLAKYEYSVAEYYTERGAWVAVVNRVEGMLRNYPDTQATRDALPLMENAYRQMQMNAQAEKVAKIIAANSSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CT4</accession>
    <name>Q32CT4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylserine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pssA</name>
        <name evidence="3" type="ordered locus">SDY_2828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404362.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CT4"/>
    <dbReference type="STRING" id="300267.SDY_2828"/>
    <dbReference type="EnsemblBacteria" id="ABB62871">
        <property type="protein sequence ID" value="ABB62871"/>
        <property type="gene ID" value="SDY_2828"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2828"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3405"/>
    <dbReference type="HOGENOM" id="CLU_051350_1_0_6"/>
    <dbReference type="OMA" id="YLSTLYI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="PTHR12586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="452" mass="52906" checksum="5B373796CD95AF6F" modified="2005-12-06" version="1">MMLSKFKRNKHQQHLAQLPKISQSVDDVDFFYAPADFRETLLEKIASAKQRICIVALYLEQDDGGKGILNALYEAKRQRPELDVRVLVDWHRAQRGRIGAAASNTNADWYCRMAQENPGVDVPVYGVPINTREALGVLHFKGFIIDDSVLYSGASLNDVYLHQHDKYRYDRYHLIRNRKMSDIMFEWVTQNIMNGRGVNRLDDVNRPKSPEIKNDIRLFRQELRDAAYHFQGDADNDQLSVTPLVGLGKSSLLNKTIFHLMPCAEQKLTICTPYFNLPAILVRNIIQLLREGKKVEILVGDKTANDFYIPEDEPFKIIGALPYLYEINLRRFLSRLQYYVNTDQLVVRLWKDDDSTYHLKGMWVDDKWMLITGNNLNPRAWRLDLENAILIHDPQLELAPQREKELELIREHTTIVKHYRDLQSIADYPVKVRKLIRRLRRIRIDRLISRIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CT9</accession>
    <name>UNG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uracil-DNA glycosylase</fullName>
            <shortName evidence="1">UDG</shortName>
            <ecNumber evidence="1">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ung</name>
        <name type="ordered locus">SDY_2823</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001262720.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404357.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CT9"/>
    <dbReference type="SMR" id="Q32CT9"/>
    <dbReference type="STRING" id="300267.SDY_2823"/>
    <dbReference type="EnsemblBacteria" id="ABB62866">
        <property type="protein sequence ID" value="ABB62866"/>
        <property type="gene ID" value="SDY_2823"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2823"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3400"/>
    <dbReference type="HOGENOM" id="CLU_032162_3_0_6"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000009938" description="Uracil-DNA glycosylase">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <sequence length="229" mass="25662" checksum="F995793824FE6137" modified="2005-12-06" version="1">MANELTWHDVLAEEKQQPYFLNTLQTVASERQSGVTIYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVRPGIATPPSLLNMYKELENTIPGFTRPNHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVISLINQHREGVVFLLWGSHAQKKGAIIDKQRHHVLKAPHPSPLSAHRGFFGCNHFVLANQWLEQHGETPIDWMPVLPAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CU8</accession>
    <name>Q32CU8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoE</name>
        <name evidence="7" type="ordered locus">SDY_2814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295364.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404348.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CU8"/>
    <dbReference type="SMR" id="Q32CU8"/>
    <dbReference type="STRING" id="300267.SDY_2814"/>
    <dbReference type="EnsemblBacteria" id="ABB62857">
        <property type="protein sequence ID" value="ABB62857"/>
        <property type="gene ID" value="SDY_2814"/>
    </dbReference>
    <dbReference type="GeneID" id="67416952"/>
    <dbReference type="KEGG" id="sdy:SDY_2814"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3389"/>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_6"/>
    <dbReference type="OMA" id="LVDMQGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014286">
        <property type="entry name" value="RNA_pol_sigma70_RpoE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02939">
        <property type="entry name" value="RpoE_Sigma70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="191" mass="21696" checksum="C71EEF5939C3611E" modified="2005-12-06" version="1">MSEQLTDQVLVERVQKGDQKAFNLLVVRYQHKVASLVSRYVPSGDVPDVVQEAFIKAYRALDSFRGDSAFYTWLYRIAVNTAKNYLVAQGRRPPSSDVDAIEAENFESGGALKEISNPENLMLSEELRQIVFRTIESLPEDLRMAITLRELDGLSYEEIAAIMDCPVGTVRSRIFRAREAIDNKVQPLIRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CV6</accession>
    <name>RECO_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recO</name>
        <name type="ordered locus">SDY_2806</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000399404.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404340.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CV6"/>
    <dbReference type="SMR" id="Q32CV6"/>
    <dbReference type="STRING" id="300267.SDY_2806"/>
    <dbReference type="EnsemblBacteria" id="ABB62849">
        <property type="protein sequence ID" value="ABB62849"/>
        <property type="gene ID" value="SDY_2806"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2806"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3381"/>
    <dbReference type="HOGENOM" id="CLU_066645_1_0_6"/>
    <dbReference type="OMA" id="YVLHSRA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000227054" description="DNA repair protein RecO">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <sequence length="242" mass="27391" checksum="D21C242C2F842D74" modified="2005-12-06" version="1">MEGWQRAFVLHSRPWSETSLMLDVFTEESGRVRLVAKGARSKRSTLKGALQPFTPLLLRFGGRGEVKTLRSAEAVSLALPLSGITLYSGLYINELLSRVLEYETRFSELFFDYLHCIQSLAGVTGTPEPALRRFELALLGHLGYGVNFTHCAGSGEPVDDTMTYRYREEKGFIASVVIDNKTFTGRQLKALNAREFPDADTLRAAKRFTRMALKPYLGGKPLKSRELFRQFMPKRTVKTHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D11</accession>
    <name>Q32D11_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yfhH</name>
        <name evidence="4" type="ordered locus">SDY_2751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D11"/>
    <dbReference type="STRING" id="300267.SDY_2751"/>
    <dbReference type="EnsemblBacteria" id="ABB62794">
        <property type="protein sequence ID" value="ABB62794"/>
        <property type="gene ID" value="SDY_2751"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2751"/>
    <dbReference type="HOGENOM" id="CLU_055769_0_2_6"/>
    <dbReference type="OMA" id="QDLEHAP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="149"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="306" mass="33726" checksum="E349F53D58062AEE" modified="2005-12-06" version="1">MEYKIHSRVSHIACCRHYFIARKDMNGLLRIRQRYQGLAQSDKKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALSEALASQPESPSEPIHNQIRGDDPLRLVGEKLIKENTAAMYATLNVNSEEKLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGFNAAAVRDMHALLATVQASSPDDLLLAISYTGVRRELNLAADEMLRVGGKVLAITGFTPNALQRRASHCLYTIAEEQATKSASISACHAQGMLTDLLFIALIQQDLELAPERIRHSEALVKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D27</accession>
    <name>Q32D27_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404269.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D27"/>
    <dbReference type="STRING" id="300267.SDY_2734"/>
    <dbReference type="EnsemblBacteria" id="ABB62778">
        <property type="protein sequence ID" value="ABB62778"/>
        <property type="gene ID" value="SDY_2734"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2734"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3295"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="96" mass="10705" checksum="75EF9AD30A61589D" modified="2005-12-06" version="1">MAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITNNFNTGQVVFRPIAGNVPSIALLMAWKKGEMKPALRDFIAIVQERLASVTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D37</accession>
    <name>HSCB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Co-chaperone protein HscB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hsc20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hscB</name>
        <name type="ordered locus">SDY_2723</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with HscA and stimulates its ATPase activity. Interacts with IscU.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000384418.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404259.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D37"/>
    <dbReference type="SMR" id="Q32D37"/>
    <dbReference type="STRING" id="300267.SDY_2723"/>
    <dbReference type="EnsemblBacteria" id="ABB62768">
        <property type="protein sequence ID" value="ABB62768"/>
        <property type="gene ID" value="SDY_2723"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2723"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3284"/>
    <dbReference type="HOGENOM" id="CLU_068529_2_0_6"/>
    <dbReference type="OMA" id="KFMAKLQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00682">
        <property type="entry name" value="HscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="PTHR14021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="SSF47144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000083048" description="Co-chaperone protein HscB">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00682"/>
        </source>
    </evidence>
    <sequence length="171" mass="20166" checksum="095193F8E9CD60C9" modified="2005-12-06" version="1">MDYFTLFGLPARYQLDTQALSLRFQDLQRQYHPDKFASGSQAEQLAAVQQSATINQAWQTLRHPLMRAEYLLSLHGFDLASEQHTVRDTAFLMEQLELREELDEIEQAKDEARLESFIKRVKKMFDTRHQLMVEQLDNETWDAVADTVRKLRFLDKLRSSAEQLEEKLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DA0</accession>
    <name>Q32DA0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acrD</name>
        <name evidence="7" type="ordered locus">SDY_2654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cell inner membrane</location>
            <topology evidence="2 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001273124.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404196.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DA0"/>
    <dbReference type="STRING" id="300267.SDY_2654"/>
    <dbReference type="EnsemblBacteria" id="ABB62705">
        <property type="protein sequence ID" value="ABB62705"/>
        <property type="gene ID" value="SDY_2654"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2654"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3203"/>
    <dbReference type="HOGENOM" id="CLU_002755_0_2_6"/>
    <dbReference type="OMA" id="FRYNEMG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="923"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="972"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1004"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1037" mass="112805" checksum="983C7E7BB1DCA93F" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DS2</accession>
    <name>Q32DS2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">elaB</name>
        <name evidence="12" type="ordered locus">SDY_2462</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ElaB/YgaM/YqjD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000070621.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404024.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DS2"/>
    <dbReference type="SMR" id="Q32DS2"/>
    <dbReference type="STRING" id="300267.SDY_2462"/>
    <dbReference type="EnsemblBacteria" id="ABB62533">
        <property type="protein sequence ID" value="ABB62533"/>
        <property type="gene ID" value="SDY_2462"/>
    </dbReference>
    <dbReference type="GeneID" id="67416700"/>
    <dbReference type="KEGG" id="sdy:SDY_2462"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2969"/>
    <dbReference type="HOGENOM" id="CLU_132623_0_2_6"/>
    <dbReference type="OMA" id="YVQENPW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043605">
        <property type="entry name" value="DUF883_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043604">
        <property type="entry name" value="DUF883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010279">
        <property type="entry name" value="YqjD/ElaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35893">
        <property type="entry name" value="PTHR35893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05957">
        <property type="entry name" value="DUF883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19029">
        <property type="entry name" value="DUF883_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DUF883" evidence="10">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF883_C" evidence="11">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="101" mass="11306" checksum="B934E815C373CF6F" modified="2005-12-06" version="1">MSNQFGDTRIDDDLTLLSETLEEVLRSSGDPADQKYVELKARAEKALDDVKKRVSQASDSYYYRAKQAVYRADDYVHEKPWQGIGVGAAVGLVLGLLLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DV4</accession>
    <name>Q32DV4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nrdA</name>
        <name evidence="14" type="ordered locus">SDY_2428</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001075157.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403992.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DV4"/>
    <dbReference type="STRING" id="300267.SDY_2428"/>
    <dbReference type="EnsemblBacteria" id="ABB62501">
        <property type="protein sequence ID" value="ABB62501"/>
        <property type="gene ID" value="SDY_2428"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2428"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2926"/>
    <dbReference type="HOGENOM" id="CLU_000404_3_0_6"/>
    <dbReference type="OMA" id="YDIHDST"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB62501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="761" mass="85790" checksum="6F10AE7EFEFD3CDA" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DZ2</accession>
    <name>Q32DZ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybjE</name>
        <name evidence="2" type="ordered locus">SDY_2389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000491144.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403954.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DZ2"/>
    <dbReference type="STRING" id="300267.SDY_2389"/>
    <dbReference type="EnsemblBacteria" id="ABB62463">
        <property type="protein sequence ID" value="ABB62463"/>
        <property type="gene ID" value="SDY_2389"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2389"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2882"/>
    <dbReference type="HOGENOM" id="CLU_045681_1_0_6"/>
    <dbReference type="OMA" id="IFITEYK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015661">
        <property type="term" value="F:L-lysine efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005642">
        <property type="entry name" value="LysO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35804">
        <property type="entry name" value="PTHR35804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03956">
        <property type="entry name" value="Lys_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="299" mass="32296" checksum="CF6BDA5641B37E01" modified="2005-12-06" version="1">MFSGLLIILVPLIVGYLIPLRQQAALKVINQLLSWMVYLILFFMGISLAFLDNLASNLLAILHYSAVSITVILLCNIAALMWLERGLPWRNHHQQEKLPSRIAMAPESLKLCGVVVIGFAIGLSGLAFLQHATEASEYTLILLLFLVGIQLRNNGMTLKQIVLNRRGMIVAVVVVASSLIGGLINAFILDLPINTALAMASGFGWYSLSGILLTESFGPVIGSAAFFNDLARELIAIMLIPGLIRRSRSTALGLCGATSMDFTLPVLQRTGGLDMVPAAIVHGFILSLLVPILIAFFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DZ5</accession>
    <name>Q32DZ5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_2386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403951.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DZ5"/>
    <dbReference type="EnsemblBacteria" id="ABB62460">
        <property type="protein sequence ID" value="ABB62460"/>
        <property type="gene ID" value="SDY_2386"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2386"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2879"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14956" checksum="E571257D6C754B4D" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERYNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E42</accession>
    <name>MUKF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromosome partition protein MukF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mukF</name>
        <name type="ordered locus">SDY_2336</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts, and probably forms a ternary complex, with MukE and MukB via its C-terminal region. The complex formation is stimulated by calcium or magnesium. It is required for an interaction between MukE and MukB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
        <text evidence="1">Restricted to the nucleoid region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MukF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001288850.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403904.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E42"/>
    <dbReference type="SMR" id="Q32E42"/>
    <dbReference type="STRING" id="300267.SDY_2336"/>
    <dbReference type="EnsemblBacteria" id="ABB62413">
        <property type="protein sequence ID" value="ABB62413"/>
        <property type="gene ID" value="SDY_2336"/>
    </dbReference>
    <dbReference type="GeneID" id="66670802"/>
    <dbReference type="KEGG" id="sdy:SDY_2336"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2820"/>
    <dbReference type="HOGENOM" id="CLU_049853_0_0_6"/>
    <dbReference type="OMA" id="AIYNNER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16337">
        <property type="entry name" value="MukF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01803">
        <property type="entry name" value="MukF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005582">
        <property type="entry name" value="Chromosome_partition_MukF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033441">
        <property type="entry name" value="MukF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038198">
        <property type="entry name" value="MukF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033440">
        <property type="entry name" value="MukF_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036141">
        <property type="entry name" value="MukF_M_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033439">
        <property type="entry name" value="MukF_WHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03882">
        <property type="entry name" value="KicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17193">
        <property type="entry name" value="MukF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17192">
        <property type="entry name" value="MukF_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018282">
        <property type="entry name" value="MukF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140570">
        <property type="entry name" value="SSF140570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0226">DNA condensation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000069941" description="Chromosome partition protein MukF">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine-zipper">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01803"/>
        </source>
    </evidence>
    <sequence length="440" mass="50579" checksum="55824FD545247EE8" modified="2005-12-06" version="1">MSEFSQTVPELVAWARKNDFSISLPVDRLSFLLAVATLNGERLDGEMSEGELVDAFRHVSDAFEQTSETIGVRANNAINDMVRQRLLNRFTSEQAEGNAIYRLTPLGIGITDYYIRQREFSTLRLSMQLSIVAGELKRAADAAEEGGDEFHWHRNVYAPLKYSVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRAAISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATMTHDDLHFVDRLVFDLQSKLDRIISWGQQSIDLWIGYDRHVHKFIRTAIDMDKNRVFAQRLRQSVQTYFDEPWALTYANADRLLDMRDEEMALRDEEVTGELPEDLEYEEFNEIREQLAAIIEEQLAVYKTRQVPLDLGLVVREYLSQYPRARHFDVARIVIDQAVRLGVAQADFTGLPAKWQPINDYGAKVQAHVIDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EN9</accession>
    <name>Q32EN9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EN9"/>
    <dbReference type="EnsemblBacteria" id="ABB62216">
        <property type="protein sequence ID" value="ABB62216"/>
        <property type="gene ID" value="SDY_2126"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2126"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="57" mass="6752" checksum="F114F3D5B58699AA" modified="2005-12-06" version="1">MAASPLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EP5</accession>
    <name>Q32EP5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403701.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EP5"/>
    <dbReference type="STRING" id="300267.SDY_2120"/>
    <dbReference type="EnsemblBacteria" id="ABB62210">
        <property type="protein sequence ID" value="ABB62210"/>
        <property type="gene ID" value="SDY_2120"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2120"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2552"/>
    <dbReference type="HOGENOM" id="CLU_190759_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016913">
        <property type="entry name" value="UCP029215"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09979">
        <property type="entry name" value="DUF2213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="9817" checksum="2E8E086C6B2D0DA7" modified="2005-12-06" version="1">MKYFFETRLGETRYRLADGSLLCKDVPIGRTGKQRYGADDLPKLKPDKFGEIVVTRSPEQVFHPATLASFEGMSISILKMKTGMCGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EQ0</accession>
    <name>Q32EQ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001125671.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403696.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EQ0"/>
    <dbReference type="STRING" id="300267.SDY_2115"/>
    <dbReference type="EnsemblBacteria" id="ABB62205">
        <property type="protein sequence ID" value="ABB62205"/>
        <property type="gene ID" value="SDY_2115"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2115"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2546"/>
    <dbReference type="HOGENOM" id="CLU_156390_0_0_6"/>
    <dbReference type="OMA" id="IKDGGFW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025127">
        <property type="entry name" value="DUF4054"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13262">
        <property type="entry name" value="DUF4054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="14886" checksum="BD964E9B0C45912D" modified="2005-12-06" version="1">MPKNQSLPAVSDFRRDFPQFADPAKYPEAQIQFRLNLADELLTENVTGKKLFPYFAGLFVAHYMTLWAADSRAMLAGGPGGSTNGVQSSKSVDKVSVSYDTSATLNPDEGFWNNTRYGAEFYQLITMFGAGGRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ET6</accession>
    <name>Q32ET6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Flagellar basal-body rod protein FlgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">flgC</name>
        <name evidence="9" type="ordered locus">SDY_2077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5 6">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001196467.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403660.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ET6"/>
    <dbReference type="STRING" id="300267.SDY_2077"/>
    <dbReference type="EnsemblBacteria" id="ABB62169">
        <property type="protein sequence ID" value="ABB62169"/>
        <property type="gene ID" value="SDY_2077"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2077"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2495"/>
    <dbReference type="HOGENOM" id="CLU_123272_1_0_6"/>
    <dbReference type="OMA" id="YVAYPNI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006299">
        <property type="entry name" value="FlgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01395">
        <property type="entry name" value="FlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="8">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="134" mass="13998" checksum="A4649A9031B551B5" modified="2005-12-06" version="1">MALLNIFDIAGSALTAQSQRLNVAASNLANADSVTGPDGQPYRAKQVVFQVNSAPGAATGGVKVADIIESQAPDKLVYEPGNPLADAKGYVKMPNVDVVGEMVNTMSASRSYQANVEVLNTVKSMMLKTLTLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ET7</accession>
    <name>Q32ET7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Basal-body rod modification protein FlgD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">flgD</name>
        <name evidence="9" type="ordered locus">SDY_2076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Required for flagellar hook formation. May act as a scaffolding protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FlgD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000020462.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403659.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ET7"/>
    <dbReference type="STRING" id="300267.SDY_2076"/>
    <dbReference type="EnsemblBacteria" id="ABB62168">
        <property type="protein sequence ID" value="ABB62168"/>
        <property type="gene ID" value="SDY_2076"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2076"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2494"/>
    <dbReference type="HOGENOM" id="CLU_047535_0_0_6"/>
    <dbReference type="OMA" id="STYAHVT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025965">
        <property type="entry name" value="FlgD_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025963">
        <property type="entry name" value="FLgD_Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13860">
        <property type="entry name" value="FlgD_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13861">
        <property type="entry name" value="FLgD_tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FLgD_tudor" evidence="8">
        <location>
            <begin position="87"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="FlgD_ig" evidence="7">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="231" mass="23626" checksum="0542425D93266BF6" modified="2005-12-06" version="1">MSIAVTTTDPTNTGVSTTSSSSLTGSNAADLQSSFLTLLVAQLKNQDPTNPMENNELTSQLAQISTVSGIEKLNTTLGSISGQIDNSQSLQASNLIGHGVIIPGTTVLAGTGSEEGAVTTTTPFGVELQQAADKVTATITDKNGAVVRTIDIGELTAVVHSFTWDGTLTDGSTAPNGSYNVAISASNGGTQLVAQPLQFALVQGVIRGNNGNTLDLGTYGTTTLDEVRQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F34</accession>
    <name>Q32F34_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403562.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F34"/>
    <dbReference type="STRING" id="300267.SDY_1971"/>
    <dbReference type="EnsemblBacteria" id="ABB62071">
        <property type="protein sequence ID" value="ABB62071"/>
        <property type="gene ID" value="SDY_1971"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1971"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2380"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15424" checksum="B74125B0C7007377" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNISMITSDDWGSYGREVPKDKHLTGKIFTQWIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F39</accession>
    <name>YOBD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0266 membrane protein YobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yobD</name>
        <name type="ordered locus">SDY_1966</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0266 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000156255.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403557.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F39"/>
    <dbReference type="STRING" id="300267.SDY_1966"/>
    <dbReference type="EnsemblBacteria" id="ABB62066">
        <property type="protein sequence ID" value="ABB62066"/>
        <property type="gene ID" value="SDY_1966"/>
    </dbReference>
    <dbReference type="GeneID" id="66674291"/>
    <dbReference type="KEGG" id="sdy:SDY_1966"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2374"/>
    <dbReference type="HOGENOM" id="CLU_133645_0_0_6"/>
    <dbReference type="OMA" id="LYLFWIR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01071">
        <property type="entry name" value="UPF0266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009328">
        <property type="entry name" value="DUF986"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06173">
        <property type="entry name" value="DUF986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020687">
        <property type="entry name" value="UCP020687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000064592" description="UPF0266 membrane protein YobD">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01071"/>
        </source>
    </evidence>
    <sequence length="152" mass="17615" checksum="06DCD3B44BC8BE19" modified="2005-12-06" version="1">MTITDLVLILFIAALLAFAIYDQFIMPRRNGPTLLAIPLLRRGRIDSVIFVGLIVILIYNNVTNHGALITTWLLSALALMGFYIFWIRVPKIIFKQKGFFFANVWIEYSRIKAMNLSEDGVLVMQLEQRRLLIRVRNIDDLEKIYKLLVSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F58</accession>
    <name>Q32F58_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ordL</name>
        <name evidence="2" type="ordered locus">SDY_1943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000134883.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403538.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F58"/>
    <dbReference type="STRING" id="300267.SDY_1943"/>
    <dbReference type="EnsemblBacteria" id="ABB62047">
        <property type="protein sequence ID" value="ABB62047"/>
        <property type="gene ID" value="SDY_1943"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1943"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2343"/>
    <dbReference type="HOGENOM" id="CLU_007884_3_0_6"/>
    <dbReference type="OMA" id="EQDAYLY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="29"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="426" mass="47155" checksum="C5EC428A2E7A533C" modified="2005-12-06" version="1">MTEHTSSYYAASANKYAPFDTLNESITCDVCVVGGGYTGLSSALHLAEAGFDVVVLEASRIGFGASGRNGGQLVNSYSRDIDVIEKSYGMDTARMLGSMMFEGGEIIRERIKRYQIDCDYRPGGLFVAMNDKQLATLEEQKENWERYGNKQLEMRDANAIRREVASDRYTGALLDHSGGHIHPLNLAIGEADAIRLNGGRVYELSAVTQIQHTTPAVVRTATGQVTAKYVIVAGNAYLGDKVEPGLAKRSMPCGTQVITTERLSEDLARSLIPKNYCVEDCNYLLDYYRLTADNRLLYGGGVVYGARDPDDVERLVVPKLLKTFPQLKGVKIDYRWTGNFLLTLSRMPQFGRLDTNIYYMQGYSGHGVTCTHLAGRLIAELLRGDAERFDAFANLPHYPFPGGRTLRVPFTAMGAAWYSLRDRLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FS4</accession>
    <name>Q32FS4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA threonylcarbamoyladenosine biosynthesis protein TsaB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yeaZ</name>
        <name evidence="5" type="ordered locus">SDY_1711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family. TsaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001220995.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403322.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FS4"/>
    <dbReference type="STRING" id="300267.SDY_1711"/>
    <dbReference type="EnsemblBacteria" id="ABB61831">
        <property type="protein sequence ID" value="ABB61831"/>
        <property type="gene ID" value="SDY_1711"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1711"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2065"/>
    <dbReference type="HOGENOM" id="CLU_064886_2_0_6"/>
    <dbReference type="OMA" id="DEVYWGC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="4">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="231" mass="25166" checksum="D786E712262B7938" modified="2005-12-06" version="1">MRILAIDTATEACSVALWNDGTVNAHFELCPREHTQRILPMVQDILTTSGTSLTDINALAYGRGPGSFTGVRIGIGIAQGLALGAELPMIGVSTLMTMAQGAWRKNGATRVLSAIDARMGEVYWAEYQRDENGIWHGEETEAVLKPELVHERMQQLSGEWVTVGTGWPAWPDLGKESGLVLRDGEVLLPAAEDMLPIACQMFAEGKTVAVEHAEPVYLRNNVAWKKLPGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FV0</accession>
    <name>Q32FV0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
            <ecNumber evidence="2">2.7.7.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24898"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="2.7.7.65"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403296.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FV0"/>
    <dbReference type="STRING" id="300267.SDY_1684"/>
    <dbReference type="EnsemblBacteria" id="ABB61805">
        <property type="protein sequence ID" value="ABB61805"/>
        <property type="gene ID" value="SDY_1684"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1684"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2031"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_16_6"/>
    <dbReference type="OMA" id="SKMYRIE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="120" mass="13561" checksum="B5D361604C0787FD" modified="2005-12-06" version="1">MFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FV9</accession>
    <name>Q32FV9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ydiJ</name>
        <name evidence="6" type="ordered locus">SDY_1675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000613037.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403287.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FV9"/>
    <dbReference type="STRING" id="300267.SDY_1675"/>
    <dbReference type="EnsemblBacteria" id="ABB61796">
        <property type="protein sequence ID" value="ABB61796"/>
        <property type="gene ID" value="SDY_1675"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1675"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2021"/>
    <dbReference type="HOGENOM" id="CLU_010756_1_0_6"/>
    <dbReference type="OMA" id="FKPNGKP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="662"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113266" checksum="A442EF5C9552663F" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FW8</accession>
    <name>Q32FW8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FW8"/>
    <dbReference type="EnsemblBacteria" id="ABB61787">
        <property type="protein sequence ID" value="ABB61787"/>
        <property type="gene ID" value="SDY_1666"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1666"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="9576" checksum="8A727673901BB5D0" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITNCCLRSLLWIFLCCRKNNATGNRGNKQWKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FX5</accession>
    <name>SAFA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Two-component-system connector protein SafA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">safA</name>
        <name type="ordered locus">SDY_1659</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Connects the signal transduction between the two-component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with PhoQ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">By acid stress, via the EvgS/EvgA system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SafA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000543400.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403271.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FX5"/>
    <dbReference type="SMR" id="Q32FX5"/>
    <dbReference type="EnsemblBacteria" id="ABB61780">
        <property type="protein sequence ID" value="ABB61780"/>
        <property type="gene ID" value="SDY_1659"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1659"/>
    <dbReference type="HOGENOM" id="CLU_2842804_0_0_6"/>
    <dbReference type="OMA" id="NYKGIMS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031411">
        <property type="entry name" value="SafA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17073">
        <property type="entry name" value="SafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000223719" description="Two-component-system connector protein SafA">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="65" mass="7256" checksum="FF8A094A4C85A7FC" modified="2005-12-06" version="1">MHATTVKNKITQRDNYKGIMSVIVVVLLLTLTLIAIFSAIDQLGISEMGRIARDLTHFIINSLQD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G72</accession>
    <name>FOLM_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Dihydromonapterin reductase</fullName>
            <shortName>H(2)-MPt reductase</shortName>
            <ecNumber evidence="1">1.5.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Dihydrofolate reductase</fullName>
            <shortName>DHFR</shortName>
            <ecNumber evidence="1">1.5.1.3</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">folM</name>
        <name type="ordered locus">SDY_1547</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydromonapterin + H(+) + NADPH = 5,6,7,8-tetrahydromonapterin + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:34847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:71175"/>
            <dbReference type="ChEBI" id="CHEBI:71177"/>
            <dbReference type="EC" id="1.5.1.50"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.50" evidence="1"/>
    <dbReference type="EC" id="1.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000520804.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403174.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G72"/>
    <dbReference type="SMR" id="Q32G72"/>
    <dbReference type="STRING" id="300267.SDY_1547"/>
    <dbReference type="EnsemblBacteria" id="ABB61683">
        <property type="protein sequence ID" value="ABB61683"/>
        <property type="gene ID" value="SDY_1547"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1547"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1856"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_6"/>
    <dbReference type="OMA" id="QIHVHAP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000339400" description="Dihydromonapterin reductase">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0AFS3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="240" mass="26348" checksum="73B942EE144E2CC3" modified="2005-12-06" version="1">MGKTQPLPILITGGGRRIGLALAWHFINQKQPVIVSYRTHYPAIDGLINAGAQCIQADFSTNDGVMAFADEVLKSTHGLRAILHNASAWMAEKPGAPLADVLACMMQIHVNTPYLLNHALERLLRGHGHAASDIIHFTDYVVERGSDKHIAYAASKAALDNMTRSFARKLAPEVKVNSIAPSLILFNEHDDAEYRQQALNKSLMKTAPGEKEVIDLVDYLLTSCFVTGRSFPLDGGRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GA4</accession>
    <name>Q32GA4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GA4"/>
    <dbReference type="STRING" id="300267.SDY_1513"/>
    <dbReference type="EnsemblBacteria" id="ABB61651">
        <property type="protein sequence ID" value="ABB61651"/>
        <property type="gene ID" value="SDY_1513"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1513"/>
    <dbReference type="HOGENOM" id="CLU_069576_0_0_6"/>
    <dbReference type="OMA" id="SWMTSIS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009677">
        <property type="entry name" value="DUF1266"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06889">
        <property type="entry name" value="DUF1266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="294" mass="34272" checksum="7D6FB8E38A1F4D1D" modified="2005-12-06" version="1">MFVFAAITSNGLNERGLITAGCSFLYLLIMMGLIVRAGFKAKKEQLHYYQAKGIEPLSIEKLQALQLIAPYRFYHKQWFETLEFWPRKPEPGKDTFQYNVLPFDSIDIISKRRESLEDQWGIEDSESYCALMEHFLSGDHGANTFKANMEEAPEQVIALLNKFAVFPSDYISDCANHSSSKSSAKLIWAAELSWMISISSTAFQNGTIEEELAWHYIMLASRKAHELFESEEDYQKNSLMGFLYWHICCYRRKLTDAELEACYRYDKQFWEHYSKKCRWPIRNVPWGASSVKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GC6</accession>
    <name>Q32GC6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403120.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GC6"/>
    <dbReference type="STRING" id="300267.SDY_1490"/>
    <dbReference type="EnsemblBacteria" id="ABB61629">
        <property type="protein sequence ID" value="ABB61629"/>
        <property type="gene ID" value="SDY_1490"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1490"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1778"/>
    <dbReference type="HOGENOM" id="CLU_150108_0_1_6"/>
    <dbReference type="OMA" id="HMTIGTD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009749">
        <property type="entry name" value="DUF1315"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07023">
        <property type="entry name" value="DUF1315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="105" mass="12176" checksum="AFDED4018E5B36E6" modified="2005-12-06" version="1">MKKRFSNLFHRSGKIMNLDDIINSMTPEVYQRLSTAVELGKWPDGVALTEEQKENCLQLVMLWQARHNTEAQHMTIDTYGQMVMKSKQQLKEDFGISAKPIAMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GD9</accession>
    <name>Q32GD9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_1477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403107.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GD9"/>
    <dbReference type="STRING" id="300267.SDY_1477"/>
    <dbReference type="EnsemblBacteria" id="ABB61616">
        <property type="protein sequence ID" value="ABB61616"/>
        <property type="gene ID" value="SDY_1477"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1477"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1763"/>
    <dbReference type="HOGENOM" id="CLU_138432_0_0_6"/>
    <dbReference type="OMA" id="MCNAGAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="117" mass="12993" checksum="FFEB103B0E47B193" modified="2005-12-06" version="1">MCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSIYMMMGGLANFVIPLITGYLSNIGLQYIIVLDFTFALLALITAIIVFIRYYRVFIIPENDVRFGERKFSIRLNTIKHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GH4</accession>
    <name>Q32GH4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_1440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403072.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GH4"/>
    <dbReference type="EnsemblBacteria" id="ABB61581">
        <property type="protein sequence ID" value="ABB61581"/>
        <property type="gene ID" value="SDY_1440"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1440"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1714"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14831" checksum="F0657DCBB7054B56" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLGQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GK8</accession>
    <name>Q32GK8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptide epimerase</fullName>
            <ecNumber evidence="5">5.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjG</name>
        <name evidence="7" type="ordered locus">SDY_1403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4 5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403038.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GK8"/>
    <dbReference type="STRING" id="300267.SDY_1403"/>
    <dbReference type="EnsemblBacteria" id="ABB61547">
        <property type="protein sequence ID" value="ABB61547"/>
        <property type="gene ID" value="SDY_1403"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1403"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1664"/>
    <dbReference type="HOGENOM" id="CLU_030273_4_3_6"/>
    <dbReference type="OMA" id="MFGCYSD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03319">
        <property type="entry name" value="L-Ala-DL-Glu_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034603">
        <property type="entry name" value="Dipeptide_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00010">
        <property type="entry name" value="dipeptide_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="6">
        <location>
            <begin position="144"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (R)-substrate epimerization" evidence="3">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (S)-substrate epimerization" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="335" mass="36462" checksum="45AA3C6488C3083D" modified="2005-12-06" version="1">MRLIRRPPRQQGVKMRTVKVFEEAWPLHTPFVIARGSRSEARVVVVELEEEGIKGTGECTPYPRYGESDASVMAQIMSVVPQLEKGLTREELQKILPAGAARNALDCALWDLAARKQQQSLADLIGITLPETVITAQTVVIGTPDQMANSASTLWQAGAKLLKVKLDNHLISERMVAIRTAVPDATLIVDANESWRTEGLAARCQLLADLGVAMLEQPLPAQDDAALENFIHPLPICADESCHTRSNLKALKGRYEMVNIKLDKTGGLTEALALATEARAQGFRLMLGCMLCTSRAISAALPLVPQVSFADLDGPTWLAVDVEPALQFTTGELHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HE8</accession>
    <name>Q32HE8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase_SAM-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fliZ</name>
        <name evidence="2" type="ordered locus">SDY_1096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402748.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HE8"/>
    <dbReference type="STRING" id="300267.SDY_1096"/>
    <dbReference type="EnsemblBacteria" id="ABB61257">
        <property type="protein sequence ID" value="ABB61257"/>
        <property type="gene ID" value="SDY_1096"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1096"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1289"/>
    <dbReference type="HOGENOM" id="CLU_132109_0_0_6"/>
    <dbReference type="OMA" id="LHCKEQS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022523">
        <property type="entry name" value="Flagellar_regulator_FliZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03823">
        <property type="entry name" value="FliZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase_SAM-like_N" evidence="1">
        <location>
            <begin position="101"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="195" mass="23127" checksum="A6D4A75D0D12AFCB" modified="2005-12-06" version="1">MPHFNFDYQEFLMMVQHLKRRPLSRYLKDFKHSQTHCAHCRKLLDRITLVRDGKIVNKIEISRLDTLLDENGWQTEQKSWAALCRFCGDLHCKTQSDFFDIIGFKQFLFEQTEMSPGTVREYVVRLRRLGNHLHEQNISLDQLQDGFLDEILAPWLPTTSTNNYRIALRKYQHYQRQTCTGLVQKSSSQPASDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HH3</accession>
    <name>Q32HH3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage tail fiber protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000111993.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402723.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HH3"/>
    <dbReference type="EnsemblBacteria" id="ABB61232">
        <property type="protein sequence ID" value="ABB61232"/>
        <property type="gene ID" value="SDY_1067"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1067"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1255"/>
    <dbReference type="HOGENOM" id="CLU_3348598_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="37" mass="4220" checksum="B321DD82FA5B9A67" modified="2005-12-06" version="1">MSVKLRLPHNSADNVDGVYYRPLQKLINGTWYNVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HJ3</accession>
    <name>Q32HJ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yedA</name>
        <name evidence="7" type="ordered locus">SDY_1047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001212213.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402703.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HJ3"/>
    <dbReference type="STRING" id="300267.SDY_1047"/>
    <dbReference type="EnsemblBacteria" id="ABB61212">
        <property type="protein sequence ID" value="ABB61212"/>
        <property type="gene ID" value="SDY_1047"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1047"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1223"/>
    <dbReference type="HOGENOM" id="CLU_033863_5_1_6"/>
    <dbReference type="OMA" id="AYGLFFY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004779">
        <property type="entry name" value="CO/AA/NH_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00950">
        <property type="entry name" value="2A78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="150"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="306" mass="32280" checksum="4A4F36A509117CAA" modified="2005-12-06" version="1">MRFRQLLPLFGALFALYIIWGSTYFVIRIGVESWPPLMMAGVRFLAAGILLLAFLLLRGHKLPPLRLLLNAALIGLLLLAVGNGMVTVAEHQNVPSGIAAVVVATVPLFTLCFSRLFGIKTRKLEWVGIAIGLAGIIMLNSGGNLSGNPWGAILILIGSISWAFGSVYGSRITLPVGMMAGAIEMLVAVVVLMIASMIAGEKLTALPSLSGFLAVGYLALFGSIIAINAYMYLIRNVSPALATSYAYVNPVVAVLLGTGLGGETLSKIEWLALGVIVFAVVLVTLGKYLFPAKPVVAPVIQDASSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-15" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HR2</accession>
    <name>CBPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Curved DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cbpA</name>
        <name type="ordered locus">SDY_0974</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK. Its activity is inhibited by the binding of CbpM.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000420595.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402634.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HR2"/>
    <dbReference type="SMR" id="Q32HR2"/>
    <dbReference type="STRING" id="300267.SDY_0974"/>
    <dbReference type="EnsemblBacteria" id="ABB61143">
        <property type="protein sequence ID" value="ABB61143"/>
        <property type="gene ID" value="SDY_0974"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0974"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1129"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_6"/>
    <dbReference type="OMA" id="WDAGFEF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01154">
        <property type="entry name" value="CbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023859">
        <property type="entry name" value="DNA-bd_curved-DNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000286885" description="Curved DNA-binding protein">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01154"/>
        </source>
    </evidence>
    <sequence length="306" mass="34436" checksum="EFA06D970D8BAA92" modified="2005-12-06" version="1">MELKDYYAIMGVKPTDDLKTIKTAYRRLARKYHPDVSKEPDAEAHFKEVAEAWEVLSDEQRRAEYDQMWQHRNDPQFNRQFHHSDGQSFNAEDFDDIFSSIFGQHARQSRQRPAARGHDIEIEVAVFLEETLTEHKRTISYNLPVYNAFGMIEQEIPKTLNVKIPAGVGNGQRIRLKGQGTPGENGGPNGDLWLVIHIAPHPLFDIVGQDLEIVVPVSPWEAALGAKVTVPTLKESILLTIPPGSQAGQRLRVKGKGLVSKKQTGDLYAVLKIVMPPKPDENTAALWQQLADAQSSFDPRKDWGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HV4</accession>
    <name>Q32HV4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC_trans_aux domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ymbA</name>
        <name evidence="2" type="ordered locus">SDY_0925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402592.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HV4"/>
    <dbReference type="STRING" id="300267.SDY_0925"/>
    <dbReference type="EnsemblBacteria" id="ABB61101">
        <property type="protein sequence ID" value="ABB61101"/>
        <property type="gene ID" value="SDY_0925"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0925"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1071"/>
    <dbReference type="HOGENOM" id="CLU_096001_3_2_6"/>
    <dbReference type="OMA" id="TDVQYVI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005586">
        <property type="entry name" value="ABC_trans_aux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03886">
        <property type="entry name" value="ABC_trans_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC_trans_aux" evidence="1">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="182" mass="19980" checksum="B64DAFD5EA89DF09" modified="2005-12-06" version="1">MTIAALWLAGCSSGEINKNYYQLPVVQSGTQSTASQGNRLLWVEQVAVPDYLAGNGVVYQTSDVKYVIANNNLWASPLDQQLRNTLVANLSTQLPGWVVASQPLGSAQDTLNVTVTEFNGRYDGKVIVSGEWLLNHQGQLIKRPFRLEGVQTQDGYDEMVKVLASVWSQEAASIAQEIKRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HW9</accession>
    <name>Q32HW9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0351</name>
        <name evidence="4" type="ordered locus">SDY_0910</name>
        <name evidence="5" type="ordered locus">SDY_0913</name>
        <name evidence="6" type="ordered locus">SDY_1244</name>
        <name evidence="7" type="ordered locus">SDY_1476</name>
        <name evidence="8" type="ordered locus">SDY_1769</name>
        <name evidence="9" type="ordered locus">SDY_2591</name>
        <name evidence="10" type="ordered locus">SDY_3881</name>
    </gene>
    <organism evidence="4 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402055.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402577.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402580.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402886.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403106.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403375.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404143.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405313.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60566">
        <property type="protein sequence ID" value="ABB60566"/>
        <property type="gene ID" value="SDY_0351"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61086">
        <property type="protein sequence ID" value="ABB61086"/>
        <property type="gene ID" value="SDY_0910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61089">
        <property type="protein sequence ID" value="ABB61089"/>
        <property type="gene ID" value="SDY_0913"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61395">
        <property type="protein sequence ID" value="ABB61395"/>
        <property type="gene ID" value="SDY_1244"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61615">
        <property type="protein sequence ID" value="ABB61615"/>
        <property type="gene ID" value="SDY_1476"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61884">
        <property type="protein sequence ID" value="ABB61884"/>
        <property type="gene ID" value="SDY_1769"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62652">
        <property type="protein sequence ID" value="ABB62652"/>
        <property type="gene ID" value="SDY_2591"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63822">
        <property type="protein sequence ID" value="ABB63822"/>
        <property type="gene ID" value="SDY_3881"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0351"/>
    <dbReference type="KEGG" id="sdy:SDY_0910"/>
    <dbReference type="KEGG" id="sdy:SDY_0913"/>
    <dbReference type="KEGG" id="sdy:SDY_1244"/>
    <dbReference type="KEGG" id="sdy:SDY_1476"/>
    <dbReference type="KEGG" id="sdy:SDY_1769"/>
    <dbReference type="KEGG" id="sdy:SDY_2591"/>
    <dbReference type="KEGG" id="sdy:SDY_3881"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1053"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8498" checksum="420CD828F4142A70" modified="2005-12-06" version="1">MLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I16</accession>
    <name>Q32I16_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Outer membrane protein 1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ompC</name>
        <name evidence="9" type="ordered locus">SDY_0861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cell outer membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the Gram-negative porin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000865544.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402530.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I16"/>
    <dbReference type="SMR" id="Q32I16"/>
    <dbReference type="STRING" id="300267.SDY_0861"/>
    <dbReference type="EnsemblBacteria" id="ABB61039">
        <property type="protein sequence ID" value="ABB61039"/>
        <property type="gene ID" value="SDY_0861"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0861"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.995"/>
    <dbReference type="HOGENOM" id="CLU_058202_0_0_6"/>
    <dbReference type="OMA" id="DNKENSW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001897">
        <property type="entry name" value="Porin_gammaproteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013793">
        <property type="entry name" value="Porin_Gram-ve_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00267">
        <property type="entry name" value="Porin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00183">
        <property type="entry name" value="ECOLIPORIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00182">
        <property type="entry name" value="ECOLNEIPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00576">
        <property type="entry name" value="GRAM_NEG_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220765" evidence="8">
        <location>
            <begin position="22"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="375" mass="41319" checksum="74665E7966E6D05E" modified="2005-12-06" version="1">MKVKVLSLLVPALLVAGAANAAEVYNKDGNKLDLYGKVDGLHYFSDDKSVDGDQTYMRLGFKGETQVTDQLTGYGQWEYQIQGNAPESENNSWTRVAFAGLKFQDIGSIDYGRNYGVVYDVTSWTDVLPEFGGDTYGSDNFMQQRGNGFATYRNTDFFGLVDGLNFAVQYQGQNGSVSGENDPDFTGHGITNNGRKALRQNGDGVGGSITYDYEGFGIGGAISSSKRTWDQNNTGLIGTGDRAETYTGGLKYDANNIYLAAQYTQTYNATRVGSLGWANKAQNFEAVAQYQFDFGLRPSLAYLQSKGKNLGVINGRNYDDEDILKYVDVGATYYFNKNMSTYVDYKINLLDDNQFTRDAGINTDNIVALGLVYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I18</accession>
    <name>Q32I18_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0716</name>
        <name evidence="4" type="ordered locus">SDY_0859</name>
        <name evidence="5" type="ordered locus">SDY_1273</name>
        <name evidence="6" type="ordered locus">SDY_1699</name>
        <name evidence="7" type="ordered locus">SDY_4424</name>
        <name evidence="8" type="ordered locus">SDY_4635</name>
        <name evidence="9" type="ordered locus">SDY_P005</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="4 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">Sd197</strain>
            <plasmid evidence="10">Plasmid pSD1_197</plasmid>
            <plasmid evidence="9">pSD1_197</plasmid>
            <plasmid evidence="9">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Sd197</strain>
            <plasmid evidence="9">pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402389.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402528.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402913.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403311.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405802.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405975.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406007.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0716"/>
    <dbReference type="EnsemblBacteria" id="ABB60900">
        <property type="protein sequence ID" value="ABB60900"/>
        <property type="gene ID" value="SDY_0716"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61037">
        <property type="protein sequence ID" value="ABB61037"/>
        <property type="gene ID" value="SDY_0859"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61422">
        <property type="protein sequence ID" value="ABB61422"/>
        <property type="gene ID" value="SDY_1273"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61820">
        <property type="protein sequence ID" value="ABB61820"/>
        <property type="gene ID" value="SDY_1699"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64311">
        <property type="protein sequence ID" value="ABB64311"/>
        <property type="gene ID" value="SDY_4424"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64484">
        <property type="protein sequence ID" value="ABB64484"/>
        <property type="gene ID" value="SDY_4635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64519">
        <property type="protein sequence ID" value="ABB64519"/>
        <property type="gene ID" value="SDY_P005"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0716"/>
    <dbReference type="KEGG" id="sdy:SDY_0859"/>
    <dbReference type="KEGG" id="sdy:SDY_1273"/>
    <dbReference type="KEGG" id="sdy:SDY_1699"/>
    <dbReference type="KEGG" id="sdy:SDY_4424"/>
    <dbReference type="KEGG" id="sdy:SDY_4635"/>
    <dbReference type="KEGG" id="sdy:SDY_P005"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1511"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15368" checksum="160134E59351326A" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVTKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I89</accession>
    <name>Q32I89_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Periplasmic glutamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glnH</name>
        <name evidence="8" type="ordered locus">SDY_0785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000843879.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402457.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I89"/>
    <dbReference type="STRING" id="300267.SDY_0785"/>
    <dbReference type="EnsemblBacteria" id="ABB60968">
        <property type="protein sequence ID" value="ABB60968"/>
        <property type="gene ID" value="SDY_0785"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0785"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.905"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_2_6"/>
    <dbReference type="OMA" id="IFATYSI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00994">
        <property type="entry name" value="PBP2_GlnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044132">
        <property type="entry name" value="PBP2_GlnH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221013" evidence="5">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="6">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="7">
        <location>
            <begin position="26"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="248" mass="27248" checksum="6DB1F3F1E286BE20" modified="2005-12-06" version="1">MKSVLKVSLAALTLAFAVSSHAVDKKLVVATDTAFVPFEFKQGDKYVGFDVDLWAAIAKELKLDYELKPMDFSGIIPALQTKNVDLALAGITITDERKKAIDFSDGYYKSGLLVMVKANNNDVKSVKDLDGKVVAVKSGTGSVDYAKANIKTKDLRQFPNIDNAYMELGTNRADAVLHDTPNILYFIKTAGNSQFKAVGDSLEAQQYGIAFPKGSDELRDKVNGALKTLRENGTYNEIYKKWFGTEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IA2</accession>
    <name>Q32IA2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical prophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000114014.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402444.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IA2"/>
    <dbReference type="EnsemblBacteria" id="ABB60955">
        <property type="protein sequence ID" value="ABB60955"/>
        <property type="gene ID" value="SDY_0771"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0771"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.887"/>
    <dbReference type="HOGENOM" id="CLU_094206_6_0_6"/>
    <dbReference type="OMA" id="DIEASWY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003458">
        <property type="entry name" value="Phage_T4_Gp38_tail_assem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02413">
        <property type="entry name" value="Caudo_TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="109" mass="12561" checksum="D786D1276B59FC2F" modified="2005-12-06" version="1">MSVKLRLPQPEGFDIEASWYYRDGEVLPVPVDYSKLAEKQRQRLLNEAKEITSDWKTELELGTISDDDKVRLTQWMEYIKAVKALDLSTATDEISFDAINWPERPDAAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IH8</accession>
    <name>NADA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Quinolinate synthase</fullName>
            <ecNumber evidence="1">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadA</name>
        <name type="ordered locus">SDY_0694</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:25889"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the quinolinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000115269.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402368.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IH8"/>
    <dbReference type="SMR" id="Q32IH8"/>
    <dbReference type="STRING" id="300267.SDY_0694"/>
    <dbReference type="EnsemblBacteria" id="ABB60879">
        <property type="protein sequence ID" value="ABB60879"/>
        <property type="gene ID" value="SDY_0694"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0694"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.805"/>
    <dbReference type="HOGENOM" id="CLU_047382_1_0_6"/>
    <dbReference type="OMA" id="CFCSTMN"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00567">
        <property type="entry name" value="NadA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023513">
        <property type="entry name" value="Quinolinate_synth_A_type1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000024974" description="Quinolinate synthase">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00567"/>
        </source>
    </evidence>
    <sequence length="347" mass="38282" checksum="33BCF129392547E5" modified="2005-12-06" version="1">MSVMFDPDTAIYPFPPKPTPLSIDEKAYYREKIKRLLKERNAVMVAHYYTDPEIQQLAEETGGCISDSLEMARFGAKHPASTLLVAGVRFMGETAKILSPEKTILMPTLQAECSLDLGCPVEEFNAFCDAHPDHTVVVYANTSAAVKARADWVVTSSIAVELIDHLDSLGEKIIWAPDKHLGRYVQKQTGADILCWQGACIVHDEFKTQALTRLQEEYLDAAILVHPESPQAIVDMADAVGSTSQLIAAAKTLPHQWLIVATDRGIFYKMQQAVPDKELLEAPTAGEGATCRSCAHCPWMAMNGLQAIAEALEQEGSNHEVHVDERLRERALVPLNRMLDFAATLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32II8</accession>
    <name>Q32II8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d terminal oxidase polypeptide subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cydB</name>
        <name evidence="8" type="ordered locus">SDY_0681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000568281.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402358.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32II8"/>
    <dbReference type="STRING" id="300267.SDY_0681"/>
    <dbReference type="EnsemblBacteria" id="ABB60869">
        <property type="protein sequence ID" value="ABB60869"/>
        <property type="gene ID" value="SDY_0681"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0681"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.795"/>
    <dbReference type="HOGENOM" id="CLU_049294_0_0_6"/>
    <dbReference type="OMA" id="FLWGVAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="379" mass="42453" checksum="FDB471F436E38995" modified="2005-12-06" version="1">MIDYEVLRFIWWLLVGVLLIGFAVTDGFDMGVGMLTRFLGRNDTERRIMINSIAPHWDGNQVWLITAGGALFAAWPMVYAAAFSGFYVAMSLVLASLFFRPVGFDYRSKIEETRWRNMWDWGIFIGSFVPPLVIGVAFGNLLQGVPFNVDEYLRLYYTGNFFQLLNPFGLLAGVVSVGMIITQGATYLQMRTVGELYLRTRATAQVAALVTLVCFALAGVWVMYGIDGYVVKSTMDHYAASNPLNKEVVREAGAWLVNFNNTPILWAIPALGVVLPLLTILTARMDKAAWAFVFSSLTLACIILTAGIAMFPFVMPSSTMMNASLTMWDATSSQLTLNVMTWVAVVLVPIILLYTAWCYWKMFGRITKEDIERNTHSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IN1</accession>
    <name>Q32IN1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhsC protein in rhs element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rhsC</name>
        <name evidence="3" type="ordered locus">SDY_0636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402315.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IN1"/>
    <dbReference type="STRING" id="300267.SDY_0636"/>
    <dbReference type="EnsemblBacteria" id="ABB60826">
        <property type="protein sequence ID" value="ABB60826"/>
        <property type="gene ID" value="SDY_0636"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0636"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.742"/>
    <dbReference type="HOGENOM" id="CLU_001218_2_1_6"/>
    <dbReference type="OMA" id="THRYLAV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001826">
        <property type="entry name" value="RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00394">
        <property type="entry name" value="RHSPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="2">
        <location>
            <begin position="46"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1087" mass="123014" checksum="5D6F4732D934DE66" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IY8</accession>
    <name>Q32IY8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Outer membrane receptor for ferric enterobactin (Enterochelin) and colicins B and D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fepA</name>
        <name evidence="13" type="ordered locus">SDY_0512</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001034900.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402208.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IY8"/>
    <dbReference type="STRING" id="300267.SDY_0512"/>
    <dbReference type="EnsemblBacteria" id="ABB60719">
        <property type="protein sequence ID" value="ABB60719"/>
        <property type="gene ID" value="SDY_0512"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0512"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.604"/>
    <dbReference type="HOGENOM" id="CLU_008287_18_2_6"/>
    <dbReference type="OMA" id="NESGRTW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221029" evidence="10">
        <location>
            <begin position="23"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="12">
        <location>
            <begin position="49"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="11">
        <location>
            <begin position="276"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB60719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="746" mass="82122" checksum="F0FE653D1461DE1E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IZ6</accession>
    <name>TAUB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Taurine import ATP-binding protein TauB</fullName>
            <ecNumber evidence="1">7.6.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tauB</name>
        <name type="ordered locus">SDY_0504</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + taurine(out) = ADP + H(+) + phosphate + taurine(in)</text>
            <dbReference type="Rhea" id="RHEA:14613"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="7.6.2.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (TauB), two transmembrane proteins (TauC) and a solute-binding protein (TauA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Taurine importer (TC 3.A.1.17.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000939378.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402200.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IZ6"/>
    <dbReference type="SMR" id="Q32IZ6"/>
    <dbReference type="STRING" id="300267.SDY_0504"/>
    <dbReference type="EnsemblBacteria" id="ABB60711">
        <property type="protein sequence ID" value="ABB60711"/>
        <property type="gene ID" value="SDY_0504"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0504"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.595"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="AFIETRE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015859">
        <property type="entry name" value="ABC_transpr_TauB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42788:SF18">
        <property type="entry name" value="PTHR42788:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51250">
        <property type="entry name" value="TAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000275844" description="Taurine import ATP-binding protein TauB">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01714"/>
        </source>
    </evidence>
    <sequence length="255" mass="28339" checksum="43C5FB656587EA07" modified="2005-12-06" version="1">MLQISHLYADYGGKPALEDINLTLESGELLVVLGPSGCGKTTLLNLIAGFVPYQHGSIQLAGKRIEGPGAERGVVFQNEGLLPWRNVQDNVAFGLQLAGIEKMQRLEIAYQMLKKVGLEGAEKRYIWQLSGGQRQRVGIARALAANPQLLLLDEPFGALDAFTRDQMQTLLLKLWQETGKQVLLITHDIEEAVFMATELVLLSSGLGRVLERLPLNFARRFVAGESSRSIKSDPQFIAMREYVLSRVFEQREAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J59</accession>
    <name>Q32J59_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ushA</name>
        <name evidence="5" type="ordered locus">SDY_0438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402137.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J59"/>
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    <dbReference type="EnsemblBacteria" id="ABB60648">
        <property type="protein sequence ID" value="ABB60648"/>
        <property type="gene ID" value="SDY_0438"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0438"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.519"/>
    <dbReference type="HOGENOM" id="CLU_005854_7_0_6"/>
    <dbReference type="OMA" id="VQPFTNM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
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        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005143139" evidence="2">
        <location>
            <begin position="26"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="35"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="4">
        <location>
            <begin position="364"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="550" mass="60775" checksum="73DE1D89D62A666B" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JB0</accession>
    <name>Q32JB0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative LRP-like transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ybaO</name>
        <name evidence="6" type="ordered locus">SDY_0384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402086.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JB0"/>
    <dbReference type="STRING" id="300267.SDY_0384"/>
    <dbReference type="EnsemblBacteria" id="ABB60597">
        <property type="protein sequence ID" value="ABB60597"/>
        <property type="gene ID" value="SDY_0384"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0384"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.455"/>
    <dbReference type="HOGENOM" id="CLU_091233_0_2_6"/>
    <dbReference type="OMA" id="HVSGDYD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="181" mass="20906" checksum="BBF12ECE56C28963" modified="2005-12-06" version="1">MVFKPHRINCRDFTFKIKLKEKKIPCGRAMLDKIDHKLLALLQQDCTLSLQALAEAVNLTTTPCWKRLKRLEDDGILIGKVALLDPEKIGLGLTAFVLIKTQHHSSEWYCRFVTVVTEMPEVLGFWRMAGEYDYLMRVQVADMKRYDEFYKRLVNSVPGLSDVTSSFAMEQIKYTTSLPIE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JB1</accession>
    <name>COF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Putative HMP-PP phosphatase</fullName>
            <ecNumber>3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cof</name>
        <name type="ordered locus">SDY_0383</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. Cof family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Could be the product of a pseudogene. It is N-terminaly truncated compared to othologs.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402085.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JB1"/>
    <dbReference type="SMR" id="Q32JB1"/>
    <dbReference type="STRING" id="300267.SDY_0383"/>
    <dbReference type="EnsemblBacteria" id="ABB60596">
        <property type="protein sequence ID" value="ABB60596"/>
        <property type="gene ID" value="SDY_0383"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0383"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.454"/>
    <dbReference type="HOGENOM" id="CLU_1757584_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023938">
        <property type="entry name" value="HMP-PP_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267:SF2">
        <property type="entry name" value="PTHR47267:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="uncertain"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342996" description="Putative HMP-PP phosphatase">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="148" mass="16353" checksum="9FA7916BEB9BD4FA" modified="2005-12-06" version="1">MPVHLNQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JU2</accession>
    <name>GLND_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="1">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="1">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="1">PII uridylyltransferase</shortName>
                <shortName evidence="1">UTase</shortName>
                <ecNumber evidence="1">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="1">UR</shortName>
                <ecNumber evidence="1">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">glnD</name>
        <name type="ordered locus">SDY_0183</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GlnD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="1"/>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001094577.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401904.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JU2"/>
    <dbReference type="SMR" id="Q32JU2"/>
    <dbReference type="STRING" id="300267.SDY_0183"/>
    <dbReference type="EnsemblBacteria" id="ABB60415">
        <property type="protein sequence ID" value="ABB60415"/>
        <property type="gene ID" value="SDY_0183"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0183"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.212"/>
    <dbReference type="HOGENOM" id="CLU_012833_0_0_6"/>
    <dbReference type="OMA" id="WIAKYVY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01693">
        <property type="entry name" value="UTase_glnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000231693" description="Bifunctional uridylyltransferase/uridylyl-removing enzyme">
        <location>
            <begin position="1"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="468"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="ACT 1" evidence="1">
        <location>
            <begin position="709"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="ACT 2" evidence="1">
        <location>
            <begin position="816"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyltransferase">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyl-removing">
        <location>
            <begin position="350"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01175"/>
        </source>
    </evidence>
    <sequence length="890" mass="102377" checksum="53AA9D4F9654BECE" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JZ1</accession>
    <name>YACG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA gyrase inhibitor YacG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yacG</name>
        <name type="ordered locus">SDY_0131</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with GyrB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA gyrase inhibitor YacG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000005042.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401855.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JZ1"/>
    <dbReference type="SMR" id="Q32JZ1"/>
    <dbReference type="STRING" id="300267.SDY_0131"/>
    <dbReference type="EnsemblBacteria" id="ABB60366">
        <property type="protein sequence ID" value="ABB60366"/>
        <property type="gene ID" value="SDY_0131"/>
    </dbReference>
    <dbReference type="GeneID" id="66671610"/>
    <dbReference type="KEGG" id="sdy:SDY_0131"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.149"/>
    <dbReference type="HOGENOM" id="CLU_178280_3_1_6"/>
    <dbReference type="OMA" id="WAAEEHK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008657">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00649">
        <property type="entry name" value="DNA_gyrase_inhibitor_YacG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005584">
        <property type="entry name" value="DNA_gyrase_inhibitor_YacG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36150">
        <property type="entry name" value="PTHR36150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03884">
        <property type="entry name" value="YacG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000056998" description="DNA gyrase inhibitor YacG">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="65" mass="7306" checksum="F2747B62AFE6479D" modified="2005-12-06" version="1">MSETITVNCPTCGKTVVWGEISPFRPFCSKRCQLIDLGEWAAEEKRIPSSGDLSESDDWSEEPKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K23</accession>
    <name>LEUD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="1">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha-IPM isomerase</fullName>
            <shortName evidence="1">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuD</name>
        <name type="ordered locus">SDY_0098</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000818229.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401823.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K23"/>
    <dbReference type="SMR" id="Q32K23"/>
    <dbReference type="STRING" id="300267.SDY_0098"/>
    <dbReference type="EnsemblBacteria" id="ABB60334">
        <property type="protein sequence ID" value="ABB60334"/>
        <property type="gene ID" value="SDY_0098"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0098"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.117"/>
    <dbReference type="HOGENOM" id="CLU_081378_0_3_6"/>
    <dbReference type="OMA" id="AFTTHTG"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000141879" description="3-isopropylmalate dehydratase small subunit">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <sequence length="201" mass="22530" checksum="F5E98B58468E7787" modified="2005-12-06" version="1">MAEKFIKHTGLVVPLDAANVDTDAIIPKQFLQKVTRTGFGAHLFNDWRFLDEKGQQPNPDFVLNFPQYQGASILLARENFGCGSSREHAPWALTDYGFKVVIAPSFADIFYGNSFNNQLLPVKLSDAEVDELFALVKANPGIHFDVDLEAQEVKAGEKTYRFTIDAFRRHCMMNGLDSIGLTLQHDDAIAAYEAKQPAFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K64</accession>
    <name>Q32K64_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">carB</name>
        <name evidence="17" type="ordered locus">SDY_0055</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001126401.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401782.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K64"/>
    <dbReference type="STRING" id="300267.SDY_0055"/>
    <dbReference type="EnsemblBacteria" id="ABB60293">
        <property type="protein sequence ID" value="ABB60293"/>
        <property type="gene ID" value="SDY_0055"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0055"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.60"/>
    <dbReference type="HOGENOM" id="CLU_000513_1_0_6"/>
    <dbReference type="OMA" id="IEPAGIH"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="679"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="937"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Oligomerization domain" evidence="13">
        <location>
            <begin position="404"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate synthetic domain" evidence="13">
        <location>
            <begin position="554"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="937"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="841"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="843"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB60293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1073" mass="117830" checksum="9484FB54384C3F40" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q326T3</accession>
    <name>Q326T3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">acp</name>
        <name evidence="1" type="synonym">acpP</name>
        <name evidence="4" type="ordered locus">SDY_P162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Sd197</strain>
            <plasmid evidence="5">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000588956.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406163.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326T3"/>
    <dbReference type="SMR" id="Q326T3"/>
    <dbReference type="EnsemblBacteria" id="ABB64675">
        <property type="protein sequence ID" value="ABB64675"/>
        <property type="gene ID" value="SDY_P162"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P162"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5721"/>
    <dbReference type="HOGENOM" id="CLU_108696_5_0_6"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="78" mass="8803" checksum="7E70BA7727A04FED" modified="2005-12-06" version="1">MIKERILSIVAFCYGIAYSKLSEETKFIEDLSADSLSLIEMLDMISFEFNLRIDESALEHIITIGDLISVVKNSTKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q326T6</accession>
    <name>Q326T6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS100 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_P159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Sd197</strain>
            <plasmid evidence="9">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase IS21/IS408/IS1162 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406160.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326T6"/>
    <dbReference type="EnsemblBacteria" id="ABB64672">
        <property type="protein sequence ID" value="ABB64672"/>
        <property type="gene ID" value="SDY_P159"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P159"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5715"/>
    <dbReference type="HOGENOM" id="CLU_020626_4_0_6"/>
    <dbReference type="OMA" id="IMERVGW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="90"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="308" mass="36021" checksum="FEFA0CBDEF7B459F" modified="2005-12-06" version="1">MPDSRNTVKRYLQAKSEPPKYTPRPAVASLLDEYRDYIRQRIADAHPYKIPATVIAREIRDQGYRGGMTILRAFIRSLSVPQEQEPAVRFETEPGRQMQVDWGTMRNGRSPLHVFVAVPGYSRMLYIEFTDNMRYDTLETCHRNAFRFFGGVPREVLYDNMKTVVLQRDAYQTGQHRFHPSLWQFGKEMGLSPRLCRPFRAQTKGKVERMVQYTRNSFYIPLMTRLRPMGSTVDVETANRHGLRWLHDVANQRKHETIQARPCDRWLEEQQSMLALPPEKKEYDVHPGENLVSFDNPVTLFVPLIMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q326V3</accession>
    <name>Q326V3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406143.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326V3"/>
    <dbReference type="EnsemblBacteria" id="ABB64655">
        <property type="protein sequence ID" value="ABB64655"/>
        <property type="gene ID" value="SDY_P142"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P142"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5699"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_9_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="62" mass="7128" checksum="B5E5F58769AF7E04" modified="2005-12-06" version="1">MCRVPGVSRSGYYDRVQHAPSDRKQSDERLKLEIKVAHIRTRETYGTRRLQTELADNGIIVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-07-13" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Z6</accession>
    <name>IPA9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>E3 ubiquitin-protein ligase ipaH9.8</fullName>
            <ecNumber>2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Invasion plasmid antigen ipaH9.8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase ipaH9.8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ipaH9.8</name>
        <name type="ordered locus">SDY_P099</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid">
        <name>pSD1_197</name>
    </geneLocation>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Exists in an autoinhibited state in the absence of substrate protein, probably due to interactions of the leucine-rich repeat domain with the catalytic domain. Is activated upon binding to a substrate protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cytoplasm. Transported into the host nucleus (By similarity).</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The LRR (leucine-rich repeat) domain forms a slightly curved solenoid and may mediate interaction with target proteins.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Ubiquitinated in the presence of host E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme and ubiquitin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LRR-containing bacterial E3 ligase family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB64612" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27"/>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64612.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406100.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Z6"/>
    <dbReference type="SMR" id="Q326Z6"/>
    <dbReference type="STRING" id="300267.SDY_2003"/>
    <dbReference type="EnsemblBacteria" id="ABB64612">
        <property type="protein sequence ID" value="ABB64612"/>
        <property type="gene ID" value="SDY_P099"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P099"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5651"/>
    <dbReference type="HOGENOM" id="CLU_018533_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044164">
        <property type="term" value="C:host cell cytosol"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044314">
        <property type="term" value="P:protein K27-linked ubiquitination"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032674">
        <property type="entry name" value="LRR_E3_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029487">
        <property type="entry name" value="NEL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14496">
        <property type="entry name" value="NEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12468">
        <property type="entry name" value="TTSSLRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0433">Leucine-rich repeat</keyword>
    <keyword id="KW-0614">Plasmid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000395758" description="E3 ubiquitin-protein ligase ipaH9.8">
        <location>
            <begin position="1"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 3">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 4">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 5">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with target proteins" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="243"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="E3 ubiquitin-protein ligase catalytic domain" evidence="1">
        <location>
            <begin position="251"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="1">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="545" mass="61973" checksum="52919F70DC1BDDE3" modified="2010-07-13" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q327A5</accession>
    <name>Q327A5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid stable inheritance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000361391.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406091.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327A5"/>
    <dbReference type="EnsemblBacteria" id="ABB64603">
        <property type="protein sequence ID" value="ABB64603"/>
        <property type="gene ID" value="SDY_P090"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P090"/>
    <dbReference type="HOGENOM" id="CLU_165524_0_0_6"/>
    <dbReference type="OMA" id="MDKRRTI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.290.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019720">
        <property type="entry name" value="Plasmid_stability_protein_StbB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038307">
        <property type="entry name" value="StbB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10784">
        <property type="entry name" value="Plasmid_stab_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="121" mass="14005" checksum="FECD0F204060EDE9" modified="2005-12-06" version="1">MDKRRTIAFKPNPDVNQTDKIVCNTLDSIPQGERSRLNRAALTADLALYRQDPRPPFLLCELLTKETTFSDIVNILRSLFPKEMVDFNSSTITQSSSQKEQKSDEETQKNVMKLINQFNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q327A7</accession>
    <name>Q327A7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000421263.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406089.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327A7"/>
    <dbReference type="EnsemblBacteria" id="ABB64601">
        <property type="protein sequence ID" value="ABB64601"/>
        <property type="gene ID" value="SDY_P088"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P088"/>
    <dbReference type="HOGENOM" id="CLU_147162_13_2_6"/>
    <dbReference type="OMA" id="GHYEMRY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="10793" checksum="76A6557EA6EDB66D" modified="2005-12-06" version="1">MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIYVLRLWYTRENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q327B3</accession>
    <name>Q327B3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000607008.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406083.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327B3"/>
    <dbReference type="SMR" id="Q327B3"/>
    <dbReference type="EnsemblBacteria" id="ABB64595">
        <property type="protein sequence ID" value="ABB64595"/>
        <property type="gene ID" value="SDY_P082"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P082"/>
    <dbReference type="HOGENOM" id="CLU_1308566_0_0_6"/>
    <dbReference type="OMA" id="QEFEHYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="212" mass="23341" checksum="B474CCF80FAD884F" modified="2005-12-06" version="1">MINGVSLQGTAGYEAHTEEGNVNVKKLLESLNSKSLGDMDKDSELAATLQKMINPSGGDGNCSGCALHACMAMLGYGVREAPVPNEISEYMTGFFHRHLEQIDSEGIVSHPNETYSKFRERIAENILQNTSKGSVVMISIEQATHWIAGFNDGEKIMFLDVQTGKGFNLYDPVEKSPDAFVDENSSVQVIHVSDQEFDHYANSSSWKSKRLC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q327L4</accession>
    <name>TYPH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidine phosphorylase</fullName>
            <ecNumber evidence="1">2.4.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TdRPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">deoA</name>
        <name type="ordered locus">SDY_4642</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine</text>
            <dbReference type="Rhea" id="RHEA:16037"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000477813.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405982.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327L4"/>
    <dbReference type="SMR" id="Q327L4"/>
    <dbReference type="STRING" id="300267.SDY_4642"/>
    <dbReference type="EnsemblBacteria" id="ABB64491">
        <property type="protein sequence ID" value="ABB64491"/>
        <property type="gene ID" value="SDY_4642"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4642"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5503"/>
    <dbReference type="HOGENOM" id="CLU_025040_0_1_6"/>
    <dbReference type="OMA" id="DVWRRMI"/>
    <dbReference type="UniPathway" id="UPA00578">
        <property type="reaction ID" value="UER00638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046104">
        <property type="term" value="P:thymidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01628">
        <property type="entry name" value="Thymid_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013465">
        <property type="entry name" value="Thymidine_Pase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02643">
        <property type="entry name" value="T_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000059067" description="Thymidine phosphorylase">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01628"/>
        </source>
    </evidence>
    <sequence length="440" mass="47196" checksum="B3BDEB1DA075D2F1" modified="2005-12-06" version="1">MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENSWQEASKAVKAAIKLADKAPESTPTVYRRISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q327P8</accession>
    <name>Q327P8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yjiO</name>
        <name evidence="9" type="ordered locus">SDY_4599</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001137027.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405948.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327P8"/>
    <dbReference type="STRING" id="300267.SDY_4599"/>
    <dbReference type="EnsemblBacteria" id="ABB64457">
        <property type="protein sequence ID" value="ABB64457"/>
        <property type="gene ID" value="SDY_4599"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4599"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5449"/>
    <dbReference type="HOGENOM" id="CLU_001265_47_2_6"/>
    <dbReference type="OMA" id="YIPLMSW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="14"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="410" mass="44763" checksum="4E2128960CA89489" modified="2005-12-06" version="1">MPRFFARHAATLFFPMALILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFRQTKGIKLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAVMGFISFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFCNRLFLFGAATISLSYIPMMSWVAVSLVILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHVWLWLVLGTSLYAFGIGLIFPTLFRFTLFSNNLPKGTVSASLNMVILMVMSVSVEIGRWLWFNGGRLPFHLLAVVAVVIVVFTLAGLLNRVRQHQAAELAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q328A8</accession>
    <name>Q328A8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405838.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328A8"/>
    <dbReference type="STRING" id="300267.SDY_4470"/>
    <dbReference type="EnsemblBacteria" id="ABB64347">
        <property type="protein sequence ID" value="ABB64347"/>
        <property type="gene ID" value="SDY_4470"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4470"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5275"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="105"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="278" mass="32193" checksum="B58B45BC99A23FB7" modified="2005-12-06" version="1">MPFYFRKECPLNSGYLRKNRPEKPDGRRAVLRSQVLELHGISHGSAGARSIATMATLRGFRMGRWLAGRLMKELGLVSCQQPAHRYKRGGHEHVTIPNHLGRQFAVTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTIKALKMAWEIRSKPAGVMFHSDQGSHYTSRQFRQLLWRYQIKQSLSRRGNCWDNSPMERFFRSLKNEWIPVTGYMNFSDAAHEITDYIVGYYNALRPHEYNGGLPPNESENRYWKNSKAVASFC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q328C4</accession>
    <name>CH60_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperonin GroEL</fullName>
            <ecNumber evidence="1">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-60</fullName>
            <shortName evidence="1">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groEL</name>
        <name evidence="1" type="synonym">groL</name>
        <name type="ordered locus">SDY_4449</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.</text>
            <dbReference type="EC" id="5.6.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000729117.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405822.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328C4"/>
    <dbReference type="SMR" id="Q328C4"/>
    <dbReference type="STRING" id="300267.SDY_4449"/>
    <dbReference type="EnsemblBacteria" id="ABB64331">
        <property type="protein sequence ID" value="ABB64331"/>
        <property type="gene ID" value="SDY_4449"/>
    </dbReference>
    <dbReference type="GeneID" id="66671945"/>
    <dbReference type="KEGG" id="sdy:SDY_4449"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5248"/>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_6"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000256986" description="Chaperonin GroEL">
        <location>
            <begin position="1"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <sequence length="548" mass="57329" checksum="CD3A0FB505F74AD1" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q328F9</accession>
    <name>Q328F9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">23S rRNA (guanosine-2'-O-)-methyltransferase RlmB</fullName>
            <ecNumber evidence="6">2.1.1.185</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">23S rRNA (guanosine2251 2'-O)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">23S rRNA Gm2251 2'-O-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yjfH</name>
        <name evidence="6" type="synonym">rlmB</name>
        <name evidence="8" type="ordered locus">SDY_4409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the ribose of guanosine 2251 in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10239"/>
            <dbReference type="Rhea" id="RHEA-COMP:10241"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.185"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.185" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001293280.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405787.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328F9"/>
    <dbReference type="STRING" id="300267.SDY_4409"/>
    <dbReference type="EnsemblBacteria" id="ABB64296">
        <property type="protein sequence ID" value="ABB64296"/>
        <property type="gene ID" value="SDY_4409"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4409"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5206"/>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_6"/>
    <dbReference type="OMA" id="QVPPYEY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070039">
        <property type="term" value="F:rRNA (guanosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01887">
        <property type="entry name" value="23SrRNA_methyltr_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024915">
        <property type="entry name" value="23S_rRNA_MeTrfase_RlmB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="7">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="243" mass="26497" checksum="788C4170421941CC" modified="2005-12-06" version="1">MSEMIYGIHAVQALLERAPERFQEVFILKGREDKRLLPLIHALESQGVVIQLANRQYLDEKSDGAVHQGIIARVKPGRQYQENDLPDLIASLDQPFLLILDGVTDPHNLGACLRSADAAGVHAVIVPKDRSAQLNATAKKVACGAAESVPLIRVTNLARTMRMLQEENIWIVGTAGEADHTLCQSKMTGRLALVMGAEGEGMRRLTREHCDELISIPMAGSVSSLNVSVATGICLFEAVRQRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q328J6</accession>
    <name>RL9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplI</name>
        <name type="ordered locus">SDY_4372</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001196060.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405750.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328J6"/>
    <dbReference type="SMR" id="Q328J6"/>
    <dbReference type="STRING" id="300267.SDY_4372"/>
    <dbReference type="EnsemblBacteria" id="ABB64259">
        <property type="protein sequence ID" value="ABB64259"/>
        <property type="gene ID" value="SDY_4372"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4372"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5161"/>
    <dbReference type="HOGENOM" id="CLU_078938_4_1_6"/>
    <dbReference type="OMA" id="MKIILTH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000236586" description="50S ribosomal protein L9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <sequence length="149" mass="15770" checksum="18F2327DB33EFAC2" modified="2005-12-06" version="1">MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNIEFFEARRAELEAKLAEVLAAANARAEKIDALETVTIASKAGDEGKLFGSIGTRDIADAVTAAGVEVAKSEVRLPNGVLRTTGEHEVSFQVHSEVFAKVIVNVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q328M9</accession>
    <name>Q328M9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjaA</name>
        <name evidence="1" type="ordered locus">SDY_4334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001326558.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405717.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328M9"/>
    <dbReference type="STRING" id="300267.SDY_4334"/>
    <dbReference type="EnsemblBacteria" id="ABB64226">
        <property type="protein sequence ID" value="ABB64226"/>
        <property type="gene ID" value="SDY_4334"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4334"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5117"/>
    <dbReference type="HOGENOM" id="CLU_154451_0_0_6"/>
    <dbReference type="OMA" id="VEERAIM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="127" mass="14447" checksum="7D57C68E88025F7C" modified="2005-12-06" version="1">MSVLYIQIRRNQITVRDLESKREVSGDAAFSNQRLLIANFFVAEKVLQDLVLQLHPRSTWHSFLPAKRMDIVVSALEMNEGGLSQVEERILHEVVAGATLMKYRQFHIHAQSAVLSDSAVMAMLKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q328V7</accession>
    <name>Q328V7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ytfR</name>
        <name evidence="5" type="ordered locus">SDY_4247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000205782.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405639.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328V7"/>
    <dbReference type="STRING" id="300267.SDY_4247"/>
    <dbReference type="EnsemblBacteria" id="ABB64148">
        <property type="protein sequence ID" value="ABB64148"/>
        <property type="gene ID" value="SDY_4247"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4247"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5008"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_6"/>
    <dbReference type="OMA" id="GFGFCPE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="259"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="500" mass="55306" checksum="E447EC0536DABC92" modified="2005-12-06" version="1">MTTDQHQEILRTEGLSKFFLGVKALDNVDFSLRRGEIMALLGENGAGKSTLIKALTGVYHADRGTIWLEGQAISPKNTAHAQQLGIGTVYQEVNLPPNMSVADNLFIGREPKRFGLLRRKEMEKRATELMASYGFSLDVREPLNRFSVAMQQIVAICRAIDLSAKVLILDEPTASLDTQEVELLFDLMRQLRDRGVSLIFVTHFLDQVYQVSNRITVLRNGSFVGCRETCELPQIELVKMMLGRELDTHALQRAGRTLLSDKPVAAFKNYGKKGTIAPFDLEVRPGEIVGLAGLLGSGRTETAEVIFGIKPADSGTALIKGKQQNLRSPHQASVLGIGFCPEDRKTDGIIAAASVRENIILALQAQRGWLRPISRKEQQEIAERFIRQLGIRTPSTEQPIEFLSGGNQQKVLLSRWLLTRPQFLILDEPTRGIDVGAHAEIIRLIETLCADGLALLVISSELEELVGYADRVIIMRDRKQVAEILLAELSVPAIMNAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Y8</accession>
    <name>Q328Y8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Selenocysteine-specific elongation factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">SelB translation factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">selB</name>
        <name evidence="8" type="ordered locus">SDY_4213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000582419.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405608.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Y8"/>
    <dbReference type="STRING" id="300267.SDY_4213"/>
    <dbReference type="EnsemblBacteria" id="ABB64117">
        <property type="protein sequence ID" value="ABB64117"/>
        <property type="gene ID" value="SDY_4213"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4213"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4953"/>
    <dbReference type="HOGENOM" id="CLU_023030_2_0_6"/>
    <dbReference type="OMA" id="YAIDRVF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015190">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015191">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004535">
        <property type="entry name" value="Transl_elong_SelB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09106">
        <property type="entry name" value="SelB-wing_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09107">
        <property type="entry name" value="SelB-wing_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00475">
        <property type="entry name" value="selB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="614" mass="68987" checksum="830F9AC2E2BE02EF" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q329E6</accession>
    <name>Q329E6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator, positive activator of uhpT transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">uhpA</name>
        <name evidence="5" type="ordered locus">SDY_4150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016525.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405550.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329E6"/>
    <dbReference type="STRING" id="300267.SDY_4150"/>
    <dbReference type="EnsemblBacteria" id="ABB64059">
        <property type="protein sequence ID" value="ABB64059"/>
        <property type="gene ID" value="SDY_4150"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4150"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4877"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_6"/>
    <dbReference type="OMA" id="HPMWRDG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="196" mass="20917" checksum="0931F89CCAE09AD9" modified="2005-12-06" version="1">MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSVHDSPALVEQALNAGARGFLSKRCSPDELIVAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q329U4</accession>
    <name>Q329U4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0438 protein YifE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yifE</name>
        <name evidence="4" type="ordered locus">SDY_3984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0438 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000841001.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405402.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329U4"/>
    <dbReference type="STRING" id="300267.SDY_3984"/>
    <dbReference type="EnsemblBacteria" id="ABB63911">
        <property type="protein sequence ID" value="ABB63911"/>
        <property type="gene ID" value="SDY_3984"/>
    </dbReference>
    <dbReference type="GeneID" id="67414448"/>
    <dbReference type="KEGG" id="sdy:SDY_3984"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4698"/>
    <dbReference type="HOGENOM" id="CLU_144599_2_2_6"/>
    <dbReference type="OMA" id="DYTIRES"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007335">
        <property type="entry name" value="DUF413"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04219">
        <property type="entry name" value="DUF413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="13134" checksum="EB2F585318770224" modified="2005-12-06" version="1">MAESFTTTNRYFDNKHYPRGFSRHGDFTIKEAQLLERHGYAFNELDLGKREPVTEEEKLFVAVCRGEREPVTEAERVWSKYMTRIKRPKRFHTLSGGKPQVEGAEDYTDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A16</accession>
    <name>Q32A16_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yigU</name>
        <name evidence="5" type="synonym">tatC</name>
        <name evidence="6" type="ordered locus">SDY_3905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000109942.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405330.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A16"/>
    <dbReference type="STRING" id="300267.SDY_3905"/>
    <dbReference type="EnsemblBacteria" id="ABB63839">
        <property type="protein sequence ID" value="ABB63839"/>
        <property type="gene ID" value="SDY_3905"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3905"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4613"/>
    <dbReference type="HOGENOM" id="CLU_031942_1_1_6"/>
    <dbReference type="OMA" id="EMSFLDH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019820">
        <property type="entry name" value="Sec-indep_translocase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01218">
        <property type="entry name" value="TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="258" mass="28945" checksum="D2383F85AF63181C" modified="2005-12-06" version="1">MSVEDTQPLITHLIELRKRLLNCIIAVIVIFLCLVYFANDIYHLVSAPLIKQLPQGSTMIATDVASPFFTPIKLTFMVSLILSAPVILYQVWAFIAPALYKHERRLVVPLLVSSSLLFYIGMAFAYFVVFPLAFGFLANTAPEGVQVSTDIASYLSFVMALFMAFGVSFEVPVAIVLLCWMGITSPEDLRKKRPYVLVGAFVVGMLLTPPDVFSQTLLAIPMYCLFEIGVFFSRFYVGKGRNREEENDAEAEREKTEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A22</accession>
    <name>PEPQ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xaa-Pro dipeptidase</fullName>
            <shortName evidence="1">X-Pro dipeptidase</shortName>
            <ecNumber evidence="1">3.4.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Imidodipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Proline dipeptidase</fullName>
            <shortName evidence="1">Prolidase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pepQ</name>
        <name type="ordered locus">SDY_3898</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Splits dipeptides with a prolyl residue in the C-terminal position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Xaa-|-Pro dipeptides. Also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.</text>
            <dbReference type="EC" id="3.4.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000444581.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405324.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A22"/>
    <dbReference type="SMR" id="Q32A22"/>
    <dbReference type="STRING" id="300267.SDY_3898"/>
    <dbReference type="MEROPS" id="M24.003"/>
    <dbReference type="EnsemblBacteria" id="ABB63833">
        <property type="protein sequence ID" value="ABB63833"/>
        <property type="gene ID" value="SDY_3898"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3898"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4606"/>
    <dbReference type="HOGENOM" id="CLU_050675_0_0_6"/>
    <dbReference type="OMA" id="DFWHKVA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016795">
        <property type="term" value="F:phosphoric triester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01279">
        <property type="entry name" value="X_Pro_dipeptid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022846">
        <property type="entry name" value="X_Pro_dipept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0224">Dipeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000303867" description="Xaa-Pro dipeptidase">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01279"/>
        </source>
    </evidence>
    <sequence length="443" mass="50191" checksum="0274903A4AF63FE8" modified="2005-12-06" version="1">MESLASLYKNHIATLQERTRDALTRFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEDVEVIALPKADGIGSLLPAARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRSFKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPEEMRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILLPGMVLTIEPGIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGIRIEDNVVIHENNVENMTRDLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A43</accession>
    <name>Q32A43_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS4 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378927.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405303.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A43"/>
    <dbReference type="STRING" id="300267.SDY_3871"/>
    <dbReference type="EnsemblBacteria" id="ABB63812">
        <property type="protein sequence ID" value="ABB63812"/>
        <property type="gene ID" value="SDY_3871"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3871"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4577"/>
    <dbReference type="HOGENOM" id="CLU_028400_1_1_6"/>
    <dbReference type="OMA" id="AGYNERW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024473">
        <property type="entry name" value="Transposases_IS4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13006">
        <property type="entry name" value="Nterm_IS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nterm_IS4" evidence="2">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="448" mass="51204" checksum="B8F3C7A216489C59" modified="2005-12-06" version="1">MFPDFFMHIGQALDLVSRYDSLRNPLTSLGDYLDPELISRCLAESGTVTLRKRRLPLEMMVWCTVGMVLERKEPLHQIVNRLDIMLPGNRPFVAPSAVIQARQRLGSEAVRRVFTKTAQLWHNATPHPHWCGLTLLAIDGVFWRTPDTPENDAAFPRQTHAGNPALYPQVKMVCQMELTSHLLTAAAFGTMKNSENELAEQLIEQTGDNTLTLMDKGYYSLGLLNGWSLAGEHRHWMIPLRKGAQYEELRKLGKGDHLVKLKTSPQARKKWPGLGNEVTARLLTVTRKGKVYHLLTSMTDAMRFPGGEMADLYSHRWEIELGYREIKQTMQLSRLTLRSKKPELVEQELWGVLLAYNLVRYQMIKMAEHLKGYWPNQLSFSESCGMVMRMLMTLQGASPGRIPELMRDLASMGQLVKLPTRRERAFPRVVKERPWKYPTAPKKSQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AB4</accession>
    <name>Q32AB4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OxyR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oxyR</name>
        <name evidence="3" type="ordered locus">SDY_3796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001025939.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405232.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AB4"/>
    <dbReference type="SMR" id="Q32AB4"/>
    <dbReference type="STRING" id="300267.SDY_3796"/>
    <dbReference type="EnsemblBacteria" id="ABB63741">
        <property type="protein sequence ID" value="ABB63741"/>
        <property type="gene ID" value="SDY_3796"/>
    </dbReference>
    <dbReference type="GeneID" id="66672127"/>
    <dbReference type="KEGG" id="sdy:SDY_3796"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4485"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_6"/>
    <dbReference type="OMA" id="DQALDIC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="305" mass="34276" checksum="714EF4169CED2EC9" modified="2005-12-06" version="1">MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGMLLVDQARTVLREVKVLKEMASQQGETMSGPLHIGLIPTVGPYLLPHIIPMLHQTFPKLEMYLHEAQTHQLLAQLDSGKLDCVILALVKESEAFIEVPLFDEPMLLAIYEDHPWANRECVPMADLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLLPALAVPPERKRDGVVYLPCIKPEPRRTIGLVYRPGSPLRSRYEQLAEAIRARMDGHFDKVLKQAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AL7</accession>
    <name>PCKA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="1">PCK</shortName>
            <shortName evidence="1">PEP carboxykinase</shortName>
            <shortName evidence="1">PEPCK</shortName>
            <ecNumber evidence="1">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pckA</name>
        <name type="ordered locus">SDY_3673</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001265675.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405129.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AL7"/>
    <dbReference type="SMR" id="Q32AL7"/>
    <dbReference type="STRING" id="300267.SDY_3673"/>
    <dbReference type="PRIDE" id="Q32AL7"/>
    <dbReference type="EnsemblBacteria" id="ABB63638">
        <property type="protein sequence ID" value="ABB63638"/>
        <property type="gene ID" value="SDY_3673"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3673"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4358"/>
    <dbReference type="HOGENOM" id="CLU_018247_0_1_6"/>
    <dbReference type="OMA" id="MRYAGEM"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000236943" description="Phosphoenolpyruvate carboxykinase (ATP)">
        <location>
            <begin position="1"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="248"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="449"/>
            <end position="450"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <sequence length="540" mass="59715" checksum="99A10B786A132C21" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AN4</accession>
    <name>RTCA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 3'-terminal phosphate cyclase</fullName>
            <shortName evidence="1">RNA cyclase</shortName>
            <shortName evidence="1">RNA-3'-phosphate cyclase</shortName>
            <ecNumber evidence="1">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rtcA</name>
        <name type="ordered locus">SDY_3655</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63621" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63621.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024259430.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405112.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AN4"/>
    <dbReference type="SMR" id="Q32AN4"/>
    <dbReference type="STRING" id="300267.SDY_3655"/>
    <dbReference type="EnsemblBacteria" id="ABB63621">
        <property type="protein sequence ID" value="ABB63621"/>
        <property type="gene ID" value="SDY_3655"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3655"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4337"/>
    <dbReference type="HOGENOM" id="CLU_027882_0_0_6"/>
    <dbReference type="OMA" id="PKPGLSH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="PTHR11096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="PTHR11096:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="SSF52913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264799" description="RNA 3'-terminal phosphate cyclase">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="283"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="342" mass="36466" checksum="6A0D2EC3D97D62AA" modified="2006-12-12" version="2">MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAATEICRATVEGAELGSQRLVFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPVGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFPLHEQYIHNLPRDQGPGNTVSLEVESENITERFFVVGEKHVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGQFTVAHPSCHLLTNIAVVERFLPVRFTLAETNGVTRVMITKLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AQ5</accession>
    <name>Q32AQ5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione-binding protein GsiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nikA</name>
        <name evidence="9" type="ordered locus">SDY_3631</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000953378.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405091.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AQ5"/>
    <dbReference type="STRING" id="300267.SDY_3631"/>
    <dbReference type="EnsemblBacteria" id="ABB63600">
        <property type="protein sequence ID" value="ABB63600"/>
        <property type="gene ID" value="SDY_3631"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3631"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4310"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_5_6"/>
    <dbReference type="OMA" id="YIPLTYQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015675">
        <property type="term" value="P:nickel cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08489">
        <property type="entry name" value="PBP2_NikA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011980">
        <property type="entry name" value="NikA_ABC_Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02294">
        <property type="entry name" value="nickel_nikA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220854" description="Glutathione-binding protein GsiB" evidence="7">
        <location>
            <begin position="23"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="8">
        <location>
            <begin position="68"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="524" mass="58801" checksum="932392C147912CAB" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AV9</accession>
    <name>Q32AV9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AV9"/>
    <dbReference type="STRING" id="300267.SDY_3572"/>
    <dbReference type="EnsemblBacteria" id="ABB63546">
        <property type="protein sequence ID" value="ABB63546"/>
        <property type="gene ID" value="SDY_3572"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3572"/>
    <dbReference type="HOGENOM" id="CLU_138563_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="114" mass="13037" checksum="2A17A1FD251BEA77" modified="2005-12-06" version="1">MGGEYWWMVIIPVGAHISFSLGYAWPLSGTSGLRCRNLLLFLLLLLGIVAGYQAHLYKQQNPGVGVRENIDIWAWRPDKLNNRLTPLRGKPQIQFRQNWPRIDGATAAYPIYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B00</accession>
    <name>Q32B00_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrite reductase (NAD(P)H) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nirD</name>
        <name evidence="3" type="ordered locus">SDY_3528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000084764.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404996.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B00"/>
    <dbReference type="SMR" id="Q32B00"/>
    <dbReference type="STRING" id="300267.SDY_3528"/>
    <dbReference type="EnsemblBacteria" id="ABB63505">
        <property type="protein sequence ID" value="ABB63505"/>
        <property type="gene ID" value="SDY_3528"/>
    </dbReference>
    <dbReference type="GeneID" id="67416998"/>
    <dbReference type="KEGG" id="sdy:SDY_3528"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4182"/>
    <dbReference type="HOGENOM" id="CLU_055690_3_0_6"/>
    <dbReference type="OMA" id="IDNRDPF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017881">
        <property type="entry name" value="NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40562">
        <property type="entry name" value="PTHR40562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="108" mass="12284" checksum="4B16AAE73EC4B786" modified="2005-12-06" version="1">MSQWKDICKIDDILPETGVCALLGDEQVAIFRPYHSDQVFAISNIDPFFESSVLSRGLIAEHQGELWVASPLKKQRFRLSDGLCMEDEQFSVKHYEARVKDGVVQLRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B43</accession>
    <name>RL5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplE</name>
        <name type="ordered locus">SDY_3484</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001096200.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404953.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B43"/>
    <dbReference type="SMR" id="Q32B43"/>
    <dbReference type="STRING" id="300267.SDY_3484"/>
    <dbReference type="EnsemblBacteria" id="ABB63462">
        <property type="protein sequence ID" value="ABB63462"/>
        <property type="gene ID" value="SDY_3484"/>
    </dbReference>
    <dbReference type="GeneID" id="64293237"/>
    <dbReference type="GeneID" id="67415349"/>
    <dbReference type="KEGG" id="sdy:SDY_3484"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4137"/>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_6"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="PRO" id="PR:Q32B43"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000243063" description="50S ribosomal protein L5">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <sequence length="179" mass="20302" checksum="B2E95A8BE4B8D2A7" modified="2005-12-06" version="1">MAKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLDNAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFERLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAKSDEEGRALLAAFDFPFRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B46</accession>
    <name>RL6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplF</name>
        <name type="ordered locus">SDY_3481</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000091945.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404950.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B46"/>
    <dbReference type="SMR" id="Q32B46"/>
    <dbReference type="STRING" id="300267.SDY_3481"/>
    <dbReference type="EnsemblBacteria" id="ABB63459">
        <property type="protein sequence ID" value="ABB63459"/>
        <property type="gene ID" value="SDY_3481"/>
    </dbReference>
    <dbReference type="GeneID" id="67415346"/>
    <dbReference type="KEGG" id="sdy:SDY_3481"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4134"/>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_6"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000265299" description="50S ribosomal protein L6">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <sequence length="177" mass="18904" checksum="946B64E9FA42FE61" modified="2005-12-06" version="1">MSRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAVEVKHADNTLTFGPRDGYADGWAQAGTARALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVINLSLGFSHPVDHQLPAGITAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B48</accession>
    <name>RS5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsE</name>
        <name type="ordered locus">SDY_3479</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text>The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000940115.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404948.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B48"/>
    <dbReference type="SMR" id="Q32B48"/>
    <dbReference type="STRING" id="300267.SDY_3479"/>
    <dbReference type="EnsemblBacteria" id="ABB63457">
        <property type="protein sequence ID" value="ABB63457"/>
        <property type="gene ID" value="SDY_3479"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3479"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4132"/>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_6"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000230369" description="30S ribosomal protein S5">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM" evidence="1">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <sequence length="167" mass="17575" checksum="C499EA64D3518CB9" modified="2005-12-06" version="1">MAHIEKQAGELQEKLIAVNRVSKTVKGGRIFSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRNMINVALNNGTLQHPVKGAHTGSRVFMQPASEGTGIIAGGAMRAVLEVAGVHNVLAKAYGSTNPINVVRATIDGLENMNSPEMVAAKRGKSVEEILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BA0</accession>
    <name>Q32BA0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhcO</name>
        <name evidence="3" type="ordered locus">SDY_3415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001029005.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404896.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BA0"/>
    <dbReference type="SMR" id="Q32BA0"/>
    <dbReference type="STRING" id="300267.SDY_3415"/>
    <dbReference type="EnsemblBacteria" id="ABB63405">
        <property type="protein sequence ID" value="ABB63405"/>
        <property type="gene ID" value="SDY_3415"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3415"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4073"/>
    <dbReference type="HOGENOM" id="CLU_121832_2_0_6"/>
    <dbReference type="OMA" id="PVEIDFI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="10766" checksum="ADB2F032AA8B36BA" modified="2005-12-06" version="1">MNIYTFDFDEIESQEDFYRDFSQAFGLAKDKVRDLDSLWDVLMNDVLPLPLEIEFVHLGEKTRRRFGALILLFDEAEEELEGHLRFNVRH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BB4</accession>
    <name>NANA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetylneuraminate lyase</fullName>
            <shortName evidence="1">NAL</shortName>
            <shortName evidence="1">Neu5Ac lyase</shortName>
            <ecNumber evidence="1">4.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetylneuraminate pyruvate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">N-acetylneuraminic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sialate lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sialic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sialic acid lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nanA</name>
        <name type="ordered locus">SDY_3400</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aceneuramate = N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000224714.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404882.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BB4"/>
    <dbReference type="SMR" id="Q32BB4"/>
    <dbReference type="STRING" id="300267.SDY_3400"/>
    <dbReference type="EnsemblBacteria" id="ABB63391">
        <property type="protein sequence ID" value="ABB63391"/>
        <property type="gene ID" value="SDY_3400"/>
    </dbReference>
    <dbReference type="GeneID" id="66506804"/>
    <dbReference type="KEGG" id="sdy:SDY_3400"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4056"/>
    <dbReference type="HOGENOM" id="CLU_049343_6_0_6"/>
    <dbReference type="OMA" id="LPPMRYK"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00954">
        <property type="entry name" value="NAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01237">
        <property type="entry name" value="N_acetylneuram_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005264">
        <property type="entry name" value="NanA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00683">
        <property type="entry name" value="nanA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_1000066933" description="N-acetylneuraminate lyase">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in proton transfer during cleavage" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01237"/>
        </source>
    </evidence>
    <sequence length="297" mass="32593" checksum="BA9F30B4A7624167" modified="2005-12-06" version="1">MATNLRGVMAALLTPFDQQQALDKASLRRLVQFNIQQGIDGLYVGGSTGEAFVQSLSEREQVLEIVAEEAKGKIKLIAHVGCVSTAESQQLAASAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVGALKQTSGDLYQMEQIRREHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVKALKEGDIQTAQKLQTECNKVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFGPVDEKYLPELKALAQQLMQERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BD4</accession>
    <name>Q32BD4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Lipopolysaccharide export system protein LptC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yrbK</name>
        <name evidence="6" type="synonym">lptC</name>
        <name evidence="8" type="ordered locus">SDY_3380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LptC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000030537.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404862.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BD4"/>
    <dbReference type="SMR" id="Q32BD4"/>
    <dbReference type="STRING" id="300267.SDY_3380"/>
    <dbReference type="EnsemblBacteria" id="ABB63371">
        <property type="protein sequence ID" value="ABB63371"/>
        <property type="gene ID" value="SDY_3380"/>
    </dbReference>
    <dbReference type="GeneID" id="66672899"/>
    <dbReference type="KEGG" id="sdy:SDY_3380"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4034"/>
    <dbReference type="HOGENOM" id="CLU_105814_2_1_6"/>
    <dbReference type="OMA" id="YWQVQSK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015221">
        <property type="term" value="F:lipopolysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01915">
        <property type="entry name" value="LPS_assembly_LptC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010664">
        <property type="entry name" value="LipoPS_assembly_LptC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026265">
        <property type="entry name" value="LptC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06835">
        <property type="entry name" value="LptC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028513">
        <property type="entry name" value="LptC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04409">
        <property type="entry name" value="LptC_YrbK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 6 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="191" mass="21703" checksum="F6BAE79EA232CD95" modified="2005-12-06" version="1">MSKARRWVIIVLSLAVLVMIGINMAEKDDTAQVVVNNNDPTYKSEHTDTLVYNPEGALSYRLIAQHVEYYSDQAVSWFTQPVLTTFDKDKIPTWSVKADKAKLTNDRMLYLYGHVEVNALVPDSQLRRITTDNAQINLVTQDVTSEDLVTLYGTTFNSSGLKMRGNLRSKNAELIEKVRTSYEIQNKQTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BF9</accession>
    <name>Q32BF9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BF9"/>
    <dbReference type="STRING" id="300267.SDY_3354"/>
    <dbReference type="EnsemblBacteria" id="ABB63346">
        <property type="protein sequence ID" value="ABB63346"/>
        <property type="gene ID" value="SDY_3354"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3354"/>
    <dbReference type="HOGENOM" id="CLU_076276_5_2_6"/>
    <dbReference type="OMA" id="MGRSTHQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="77" mass="8625" checksum="956E98ACF4030C76" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGRGGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BM2</accession>
    <name>Q32BM2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">yqjD</name>
        <name evidence="12" type="ordered locus">SDY_3285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ElaB/YgaM/YqjD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000031415.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404774.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BM2"/>
    <dbReference type="SMR" id="Q32BM2"/>
    <dbReference type="STRING" id="300267.SDY_3285"/>
    <dbReference type="EnsemblBacteria" id="ABB63283">
        <property type="protein sequence ID" value="ABB63283"/>
        <property type="gene ID" value="SDY_3285"/>
    </dbReference>
    <dbReference type="GeneID" id="66672999"/>
    <dbReference type="KEGG" id="sdy:SDY_3285"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3927"/>
    <dbReference type="HOGENOM" id="CLU_132623_4_2_6"/>
    <dbReference type="OMA" id="KDQAFSE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043605">
        <property type="entry name" value="DUF883_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043604">
        <property type="entry name" value="DUF883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010279">
        <property type="entry name" value="YqjD/ElaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35893">
        <property type="entry name" value="PTHR35893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05957">
        <property type="entry name" value="DUF883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19029">
        <property type="entry name" value="DUF883_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DUF883" evidence="10">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DUF883_C" evidence="11">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="101" mass="11051" checksum="C2CBCE2A482BCC14" modified="2005-12-06" version="1">MSKEHTTEHLRAELKSLSDTLEEVLSSSGEKSKEELSKIRSKAEQALKQSRYRLGETGDAIAKQTRVAAARADEYVRENPWTGVGIGAAIGVVLGVLLSRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BQ2</accession>
    <name>RS21_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsU</name>
        <name type="ordered locus">SDY_3249</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001144069.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404744.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BQ2"/>
    <dbReference type="SMR" id="Q32BQ2"/>
    <dbReference type="STRING" id="300267.SDY_3249"/>
    <dbReference type="EnsemblBacteria" id="ABB63253">
        <property type="protein sequence ID" value="ABB63253"/>
        <property type="gene ID" value="SDY_3249"/>
    </dbReference>
    <dbReference type="GeneID" id="9732014"/>
    <dbReference type="KEGG" id="sdy:SDY_3249"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3883"/>
    <dbReference type="HOGENOM" id="CLU_159258_1_0_6"/>
    <dbReference type="OMA" id="FKRSCQK"/>
    <dbReference type="PRO" id="PR:Q32BQ2"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018278">
        <property type="entry name" value="Ribosomal_S21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01181">
        <property type="entry name" value="RIBOSOMAL_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000266765" description="30S ribosomal protein S21">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="71" mass="8500" checksum="B2E8A18BFBB2F685" modified="2007-01-23" version="3">MPVIKVRENEPFDVALRRFKRSCEKAGVLAEVRRREFYEKPTTERKRAKASAVKRHAKKLARENARRTRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BS7</accession>
    <name>Q32BS7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4 6">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">plsC</name>
        <name evidence="9" type="ordered locus">SDY_3219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4 6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000965721.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404719.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BS7"/>
    <dbReference type="STRING" id="300267.SDY_3219"/>
    <dbReference type="EnsemblBacteria" id="ABB63228">
        <property type="protein sequence ID" value="ABB63228"/>
        <property type="gene ID" value="SDY_3219"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3219"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3844"/>
    <dbReference type="HOGENOM" id="CLU_027938_10_3_6"/>
    <dbReference type="OMA" id="KQRIKLW"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="8">
        <location>
            <begin position="67"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="245" mass="27438" checksum="F56C5BF906A2D15D" modified="2005-12-06" version="1">MLYIFRLIITVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVTASNIVQPPTVTVGKKSLQWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSTTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAEREAAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BX0</accession>
    <name>Q32BX0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proline aminopeptidase P II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepP</name>
        <name evidence="8" type="ordered locus">SDY_3173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001290106.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404676.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BX0"/>
    <dbReference type="STRING" id="300267.SDY_3173"/>
    <dbReference type="MEROPS" id="M24.004"/>
    <dbReference type="EnsemblBacteria" id="ABB63185">
        <property type="protein sequence ID" value="ABB63185"/>
        <property type="gene ID" value="SDY_3173"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3173"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3791"/>
    <dbReference type="HOGENOM" id="CLU_017266_1_0_6"/>
    <dbReference type="OMA" id="GWADTEL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="441" mass="49824" checksum="247A1657F1CB7E33" modified="2005-12-06" version="1">MSEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSEYPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRVRDLTAEIWFGRRLGQDAAPEKLGVDRALAFSEINQQLYQLLNGLDVVYHAQGEYAYADEIVNSALEKLRKGSRQNLTAPATMIDWRPIVHEMRLFKSPEEIAVLRRAGEITALAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGCILHYTENECELRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREIYDIVLESLETSLRLYRPGTSIQEITGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPFFMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGIGIRIEDDIVITETGNENLTASVVKKPEEIEALMAAARKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C49</accession>
    <name>Q32C49_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C49"/>
    <dbReference type="STRING" id="300267.SDY_3090"/>
    <dbReference type="EnsemblBacteria" id="ABB63106">
        <property type="protein sequence ID" value="ABB63106"/>
        <property type="gene ID" value="SDY_3090"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="540" mass="59607" checksum="BB56906B143157F6" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C72</accession>
    <name>Q32C72_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C72"/>
    <dbReference type="EnsemblBacteria" id="ABB63083">
        <property type="protein sequence ID" value="ABB63083"/>
        <property type="gene ID" value="SDY_3066"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3066"/>
    <dbReference type="HOGENOM" id="CLU_3204959_0_0_6"/>
    <dbReference type="OMA" id="NTNENHY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="51" mass="5961" checksum="F978434F55E2D221" modified="2005-12-06" version="1">MLVTFLLRKRKEKKAKVRQYANSNENDYQFDVVLILLCADFVTCVLEIHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CI8</accession>
    <name>Q32CI8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nlpD</name>
        <name evidence="4" type="ordered locus">SDY_2941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001272592.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404458.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CI8"/>
    <dbReference type="SMR" id="Q32CI8"/>
    <dbReference type="STRING" id="300267.SDY_2941"/>
    <dbReference type="EnsemblBacteria" id="ABB62967">
        <property type="protein sequence ID" value="ABB62967"/>
        <property type="gene ID" value="SDY_2941"/>
    </dbReference>
    <dbReference type="GeneID" id="66673384"/>
    <dbReference type="KEGG" id="sdy:SDY_2941"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3533"/>
    <dbReference type="HOGENOM" id="CLU_029425_0_1_6"/>
    <dbReference type="OMA" id="TMFLIAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220646" evidence="2">
        <location>
            <begin position="25"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="379" mass="40149" checksum="A8E6A2B8456105FE" modified="2005-12-06" version="1">MSAGSPKFTVRRIAALSLVSLWLAGCSDTSNPPAPVSSVNGNAPANTNSGMLITPPPKMGTTSTAQQPQIQPVQQPQIQATQQPQIQPVQPVAQQPVQMENGRIVYNRQYGNIPKGSYSGSTYTVKKGDTLFYIAWITGNDFRDLAQRNNIQAPYALNVGQTLQVGNASGTPITGGNAITQADAAEQGVVIKPAQNSTVAVASQPTITYSESSGEQSANKMLPNNKPTATTVTAPVTVPTASTTEPTVSSTSTSTPISTWRWPTEGKVIETFGASEGGNKGIDIAGSKGQAIIATADGRVVYAGNALRGYGNLIIIKHNDDYLSAYAHNDTMLVREQQEVKAGQKIATMGSTGTSSTRLHFEIRYKGKSVNPLRYLPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CK6</accession>
    <name>Q32CK6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional repression of hyc and hyp operons</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hycA</name>
        <name evidence="1" type="ordered locus">SDY_2922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000158076.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404440.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CK6"/>
    <dbReference type="STRING" id="300267.SDY_2922"/>
    <dbReference type="EnsemblBacteria" id="ABB62949">
        <property type="protein sequence ID" value="ABB62949"/>
        <property type="gene ID" value="SDY_2922"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2922"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3510"/>
    <dbReference type="HOGENOM" id="CLU_115336_0_0_6"/>
    <dbReference type="OMA" id="HAMSCAA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021285">
        <property type="entry name" value="Tscrpt_reg_HycA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11046">
        <property type="entry name" value="HycA_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="153" mass="17669" checksum="E9FF98172650380E" modified="2005-12-06" version="1">MTIWEISEKADYIAQRHRRLQDQWHIYCNSLVQGITLSKARLHHVMSCAPDKELCFVLFEHFRIYVTLADGFNSHTIEYYVETKEGEDKQRIAQAQLSIDGMIDGKVNIRDREQVLEHYLEKIAGVYDSLYTAIENNVPVNLSQLVKGQSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CS0</accession>
    <name>Q32CS0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404376.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CS0"/>
    <dbReference type="STRING" id="300267.SDY_2846"/>
    <dbReference type="EnsemblBacteria" id="ABB62885">
        <property type="protein sequence ID" value="ABB62885"/>
        <property type="gene ID" value="SDY_2846"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2846"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3419"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_3_6"/>
    <dbReference type="OMA" id="GRIKNEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="144"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="255" mass="28871" checksum="BBD01AA998864B6E" modified="2005-12-06" version="1">MELDILKKAEEIIKKDPGISISHLNNREKTKIADALRQTYPLTELLHILGLARSSYFYHRAALKAGDKYATIRTMLTDIFNSNYQCYGYRRLHATLRHEGVRLSEKVVRRLMVEEQLVVSRNRYSSYCGEIGPAPDNLIARDFKAEQPNQKWLTDITEFQLPAGKVWLSPVVDCFDGKVVSRSLSTRPDAELVNTMLDSAVETLNAGERPVIHSDRGGHYRWPGWLERVNAAGLIRSMSRKGCSPDNAACEGFFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CU6</accession>
    <name>TRMN6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA1(Val) (adenine(37)-N6)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.223</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA m6A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfiC</name>
        <name type="ordered locus">SDY_2816</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43160"/>
            <dbReference type="Rhea" id="RHEA-COMP:10369"/>
            <dbReference type="Rhea" id="RHEA-COMP:10370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.223"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62859" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.1.1.223" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62859.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005017152.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404350.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CU6"/>
    <dbReference type="SMR" id="Q32CU6"/>
    <dbReference type="STRING" id="300267.SDY_2816"/>
    <dbReference type="EnsemblBacteria" id="ABB62859">
        <property type="protein sequence ID" value="ABB62859"/>
        <property type="gene ID" value="SDY_2816"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2816"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3392"/>
    <dbReference type="HOGENOM" id="CLU_061983_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016430">
        <property type="term" value="F:tRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01872">
        <property type="entry name" value="tRNA_methyltr_YfiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022882">
        <property type="entry name" value="tRNA_adenine-N6_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000387435" description="tRNA1(Val) (adenine(37)-N6)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="245" mass="27244" checksum="F422E5DA319CA3A4" modified="2009-11-03" version="2">MSQSTSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRCLDIGAGSGLLALMLAQRTDDSVMIDAVELESEAAAQAQENINQSPWAERINVHTADIQQWITQQTVRFDLIISNPPYYQQGVECSTPQREQARYTTTLDHPSLLACAAECITEEGFFCVVLPEQIGNGFTELALSMGWHLRLRTDVAENEARLPHRVLLAFSPKAGECFSDRLIIRGSDQNYSEAYTALTQAFYLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CW8</accession>
    <name>Q32CW8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404328.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CW8"/>
    <dbReference type="STRING" id="300267.SDY_2794"/>
    <dbReference type="EnsemblBacteria" id="ABB62837">
        <property type="protein sequence ID" value="ABB62837"/>
        <property type="gene ID" value="SDY_2794"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2794"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3366"/>
    <dbReference type="HOGENOM" id="CLU_2751744_0_0_6"/>
    <dbReference type="OMA" id="GVEYSHG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036709">
        <property type="entry name" value="Autotransporte_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006315">
        <property type="entry name" value="OM_autotransptr_brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103515">
        <property type="entry name" value="SSF103515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01414">
        <property type="entry name" value="autotrans_barl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="70" mass="7617" checksum="EE32B45C63D3AD6B" modified="2005-12-06" version="1">MRKEFVDDNRVKVNNDGNFVNDLSGRRGIYQAGIKASFSSTLSGHLGVEYSHGAGVESPWNAVAGVNWSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CX9</accession>
    <name>RS16_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsP</name>
        <name type="ordered locus">SDY_2783</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000256450.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404317.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CX9"/>
    <dbReference type="SMR" id="Q32CX9"/>
    <dbReference type="STRING" id="300267.SDY_2783"/>
    <dbReference type="EnsemblBacteria" id="ABB62826">
        <property type="protein sequence ID" value="ABB62826"/>
        <property type="gene ID" value="SDY_2783"/>
    </dbReference>
    <dbReference type="GeneID" id="67414073"/>
    <dbReference type="KEGG" id="sdy:SDY_2783"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3354"/>
    <dbReference type="HOGENOM" id="CLU_100590_5_1_6"/>
    <dbReference type="OMA" id="GFYNPIA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000243870" description="30S ribosomal protein S16">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <sequence length="82" mass="9191" checksum="F94D07049A6D489D" modified="2005-12-06" version="1">MVTIRLARHGAKKRPFYQVVVADSRNARNGRFIERVGFFNPIASEKEEGTRLDLDRIAHWVGQGATISDRVAALIKEVNKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D82</accession>
    <name>Q32D82_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydrogenase 4 membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hyfC</name>
        <name evidence="6" type="ordered locus">SDY_2672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404214.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D82"/>
    <dbReference type="STRING" id="300267.SDY_2672"/>
    <dbReference type="EnsemblBacteria" id="ABB62723">
        <property type="protein sequence ID" value="ABB62723"/>
        <property type="gene ID" value="SDY_2672"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2672"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3223"/>
    <dbReference type="HOGENOM" id="CLU_015134_2_1_6"/>
    <dbReference type="OMA" id="MRIFRVP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="322" mass="35169" checksum="6DC9E4E6CEA9AB49" modified="2005-12-06" version="1">MPSKEITMRQTLCDGYLVIFALAQAVILLMLTPLFTGISRQIRARMHSHRGPGIWQDYRDIHKLFKRQEVAPTSSGLMFRLMPWVLISSMLVLAMALPLFITVSPFAGGGDLITLIYLLALFRFFFALSGLDTGSPFAGVGASRELTLGILVEPMLILSLLVLALIADSTHIEMISNTLAMGWNSPLTTVLALLACGFACFIEMGKIPFDVAEAEQELQEGPLTEYSGAGLALAKWGLGLKQVVMAALFVALFLPFGRAQELSLACLLTSLVVTLLKVLLIFVLASIAENTLARGRFLLIHHVTWLGFSLAALAWVFWLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DE7</accession>
    <name>Q32DE7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase TnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000604899.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404149.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DE7"/>
    <dbReference type="STRING" id="300267.SDY_2599"/>
    <dbReference type="EnsemblBacteria" id="ABB62658">
        <property type="protein sequence ID" value="ABB62658"/>
        <property type="gene ID" value="SDY_2599"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2599"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3137"/>
    <dbReference type="HOGENOM" id="CLU_101320_2_1_6"/>
    <dbReference type="OMA" id="HILFRAK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="180" mass="20969" checksum="CFE02EB18326941A" modified="2005-12-06" version="1">MILWSMNKETDIRRGRHCVFLMHVHLVFVTRYRRQIFDYDATEKLRTYFSNVCADFEAELVEMDGEPDHVHLLITYPPKLAISSLVNSLKGVSGRLLRRARPDIAVRYYYKGVLWSPGYFASSCGGAPISVIRQYIEQQQTPGQVENRALYPRPEGRGFTAHRINKKQQGYFSCRLSFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DG1</accession>
    <name>Q32DG1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_2583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000366018.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404135.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DG1"/>
    <dbReference type="STRING" id="300267.SDY_2583"/>
    <dbReference type="MEROPS" id="M42.008"/>
    <dbReference type="EnsemblBacteria" id="ABB62644">
        <property type="protein sequence ID" value="ABB62644"/>
        <property type="gene ID" value="SDY_2583"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2583"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3117"/>
    <dbReference type="HOGENOM" id="CLU_047249_0_2_6"/>
    <dbReference type="OMA" id="YTLDNKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="345" mass="37583" checksum="81F1E3B031262DA2" modified="2005-12-06" version="1">MDLSLLKALSEADAIASSEQEVRQILLEEADRLQKEVRFDGLGSVLIRLNESTGPKVMICAHMDEVGFMVRSISREGAIDVLPVGNVRMAARQLQPVRITTREECKIPGLLDGDRQGNDVSAMRVDIGARSYDEVMQAGIRPGDRVTFDTTFQVLPHQRVMGKAFDDHLGCYLLVTLLRELHDAELPAEVWLVASFSEEVGLRGGQTATRAVSPDVAIVLDTACWAKNFDYGAANYRQIGNGPMLVLSDKSLIAPPKLTAWIETVAAEIGVPLQADMFSNGGTDGGAVHLTGTGVPTVMMGPATRHGHCAASIADCRDILQMEQLLFALIQRLTRETVVQLTDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DH0</accession>
    <name>Q32DH0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_2571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001283492.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404126.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DH0"/>
    <dbReference type="STRING" id="300267.SDY_2571"/>
    <dbReference type="EnsemblBacteria" id="ABB62635">
        <property type="protein sequence ID" value="ABB62635"/>
        <property type="gene ID" value="SDY_2571"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2571"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3101"/>
    <dbReference type="HOGENOM" id="CLU_013748_3_3_6"/>
    <dbReference type="OMA" id="PGPYGCL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008949">
        <property type="term" value="F:oxalyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033611">
        <property type="term" value="P:oxalate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017660">
        <property type="entry name" value="Oxalyl-CoA_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03254">
        <property type="entry name" value="oxalate_oxc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="10"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="202"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="402"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="564" mass="60609" checksum="945E932CEFDB1410" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DJ1</accession>
    <name>Q32DJ1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Outer membrane FadL protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Outer membrane flp protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fadL</name>
        <name evidence="13" type="ordered locus">SDY_2545</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OmpP1/FadL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404105.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DJ1"/>
    <dbReference type="SMR" id="Q32DJ1"/>
    <dbReference type="STRING" id="300267.SDY_2545"/>
    <dbReference type="EnsemblBacteria" id="ABB62614">
        <property type="protein sequence ID" value="ABB62614"/>
        <property type="gene ID" value="SDY_2545"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2545"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3063"/>
    <dbReference type="HOGENOM" id="CLU_035981_0_0_6"/>
    <dbReference type="OMA" id="NRYGFTY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005017">
        <property type="entry name" value="OMPP1/FadL/TodX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35093">
        <property type="entry name" value="PTHR35093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03349">
        <property type="entry name" value="Toluene_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220667" description="Long-chain fatty acid transport protein" evidence="12">
        <location>
            <begin position="28"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB62614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="448" mass="48766" checksum="1CD509C23489DF78" modified="2005-12-06" version="1">MVMSQKTLFTKSALAVAVALISTQAWSAGFQLNEFSSSGLGRAYSGEGAIADDAGNVSRNPALITMFDRPTFSAGAVYIDPDVNISGTSPSGRSLKADNIAPTAWVPNMHFVAPINDQFGWGASITSNYGLATEFNDTYAGGSVGGTTDLETMNLNLSGAYRLNNAWSFGLGFNAVYARAKIERFAGDLGQLVAGQIMQSPAGQTQQGQALAATANGIDSNTKIAHLNGNQWGFGWNAGILYELDKNNRYALTYRSEVKIDFKGNYSSDLNRVFNNYGLPIPTATGGATQSGYLTLNLPEMWEVSGYNRVDPQWAIHYSLAYTSWSQFQQLKATSTSGDTLFQKHEGFKDAYRIALGTTYYYDDNWTFRTGIAFDDSPVPAQNRSISIPDQDRFWLSAGTTYAFNKDASVDVGVSYMHGQSVKINEGPYQLESEGKAWLFGTNFNYAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DK7</accession>
    <name>PRMB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L3 glutamine methyltransferase</fullName>
            <shortName evidence="1">L3 MTase</shortName>
            <ecNumber evidence="1">2.1.1.298</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N5-glutamine methyltransferase PrmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prmB</name>
        <name type="synonym">yfcB</name>
        <name type="ordered locus">SDY_2530</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the 50S ribosomal protein L3 on 'Gln-150'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:45020"/>
            <dbReference type="Rhea" id="RHEA-COMP:11063"/>
            <dbReference type="Rhea" id="RHEA-COMP:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.298"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62599" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.298" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62599.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001306448.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404089.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DK7"/>
    <dbReference type="SMR" id="Q32DK7"/>
    <dbReference type="STRING" id="300267.SDY_2530"/>
    <dbReference type="EnsemblBacteria" id="ABB62599">
        <property type="protein sequence ID" value="ABB62599"/>
        <property type="gene ID" value="SDY_2530"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2530"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3045"/>
    <dbReference type="HOGENOM" id="CLU_018398_5_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02125">
        <property type="entry name" value="L3_methyltr_PrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017127">
        <property type="entry name" value="Ribosome_L3_Gln-N5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037167">
        <property type="entry name" value="Mtase_YfcB_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03533">
        <property type="entry name" value="L3_gln_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000414182" description="50S ribosomal protein L3 glutamine methyltransferase">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="310" mass="35016" checksum="3F43E8DB015C2660" modified="2011-12-14" version="2">MDKIFVDEAVNELQTIQDMLRWSVSRFSAANIWYGHGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVNERIPVAYLTNKAWFCGHEFYVDERVLVPRSPIGELINNKFAGLISKQPQHILDMCTGSGCIAIACAYAFPEAEVDAVDISPDALAVAEQNIEEHGLIHNVIPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDGLKLTRRILGNAADYLADDGVLICEVGNSMVHLMEQYPDVPFTWLEFDNGGDGVFMLTKEQLLAAREHFAIYKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DK8</accession>
    <name>AROC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate synthase</fullName>
            <shortName evidence="1">CS</shortName>
            <ecNumber evidence="1">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroC</name>
        <name type="ordered locus">SDY_2528</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="1">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001297933.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404088.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DK8"/>
    <dbReference type="SMR" id="Q32DK8"/>
    <dbReference type="STRING" id="300267.SDY_2528"/>
    <dbReference type="EnsemblBacteria" id="ABB62597">
        <property type="protein sequence ID" value="ABB62597"/>
        <property type="gene ID" value="SDY_2528"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2528"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3044"/>
    <dbReference type="HOGENOM" id="CLU_034547_0_2_6"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000256334" description="Chorismate synthase">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="293"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <sequence length="361" mass="39151" checksum="D8FD5ED44CCD04D6" modified="2005-12-06" version="1">MAGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLEIKDWSQVEQNPFFCPDPDKIDALDELMRALKKEGDSIGAKVTVVASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGDGFDVVALRGSQNRDEITKDGFQSNHAGGILGGISSGQQIIAHMALKPTSSITVPGRTINRFGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRQRAQNADVKTDIPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DM6</accession>
    <name>Q32DM6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysine-, arginine-, ornithine-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argT</name>
        <name evidence="8" type="ordered locus">SDY_2509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000733533.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404070.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DM6"/>
    <dbReference type="STRING" id="300267.SDY_2509"/>
    <dbReference type="EnsemblBacteria" id="ABB62579">
        <property type="protein sequence ID" value="ABB62579"/>
        <property type="gene ID" value="SDY_2509"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2509"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3024"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_0_6"/>
    <dbReference type="OMA" id="LYPTSYH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005768">
        <property type="entry name" value="Lys_Arg_Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01096">
        <property type="entry name" value="3A0103s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221067" evidence="6">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="7">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="260" mass="28000" checksum="773B92B53F061926" modified="2005-12-06" version="1">MKKLILALSLLVGLSAAASSYAALPETVRIGTDTIYAPFSSKDAKGDFVGFDIDLGNEMCKRMQVKCTWVASDFDALIPSLKAKKIDAIISSLSITDKRQQEIAFSDKLYAADSRLIAAKGSPIQPTLDSLKGKHVGVLQGSTQEAYANETWRSKGVDVVAYANQDLVYSDLAAGRLDAALQDEVAASEGFLKQPAGKDFAFAGSSVKDKKYFGDGTGVGLRKDDAELTAAFNKALGELRQDGTYDKMAKKYFDFNVYGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DQ1</accession>
    <name>NUOA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoA</name>
        <name type="ordered locus">SDY_2484</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000062997.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404045.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DQ1"/>
    <dbReference type="SMR" id="Q32DQ1"/>
    <dbReference type="STRING" id="300267.SDY_2484"/>
    <dbReference type="EnsemblBacteria" id="ABB62554">
        <property type="protein sequence ID" value="ABB62554"/>
        <property type="gene ID" value="SDY_2484"/>
    </dbReference>
    <dbReference type="GeneID" id="66673829"/>
    <dbReference type="KEGG" id="sdy:SDY_2484"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2995"/>
    <dbReference type="HOGENOM" id="CLU_119549_2_0_6"/>
    <dbReference type="OMA" id="CGVDPVG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000362780" description="NADH-quinone oxidoreductase subunit A">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <sequence length="147" mass="16457" checksum="1F9E0804B2B0D1B5" modified="2005-12-06" version="1">MSMSTSTEVIAHHWAFAIFLIVAIGLCCLMLVGGWFLGGRARARSKNVPFESGIDSVGSARLRLSAKFYLVAMFFVIFDVEALYLFAWSTSIRESGWVGFVEAAIFIFVLLAGLVYLVRIGALDWTPARSRRERMNPETNSIANRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DQ4</accession>
    <name>Q32DQ4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NADH dehydrogenase I subunit E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">NDH-1 subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nuoE</name>
        <name evidence="10" type="ordered locus">SDY_2481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000545040.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404042.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DQ4"/>
    <dbReference type="STRING" id="300267.SDY_2481"/>
    <dbReference type="EnsemblBacteria" id="ABB62551">
        <property type="protein sequence ID" value="ABB62551"/>
        <property type="gene ID" value="SDY_2481"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2481"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2992"/>
    <dbReference type="HOGENOM" id="CLU_054362_2_0_6"/>
    <dbReference type="OMA" id="HIIRYCD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="166" mass="18606" checksum="A1F754D45B9B9107" modified="2005-12-06" version="1">MHENQQPQTEAFELSAAEREAIEHEMHHYEDPRAASIEALKIVQKQRGWVPDGAIHAIADVLGIPASDVEGVATFYSQIFRQPVGRHVIRYCDSVVCHINGYQGIQAALEKKLNIKPGQTTFDGRFTLLPTCCLGNCDKGLNMMIDEDTHAHLTPEAIPELLERYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DT7</accession>
    <name>Q32DT7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DT7"/>
    <dbReference type="EnsemblBacteria" id="ABB62518">
        <property type="protein sequence ID" value="ABB62518"/>
        <property type="gene ID" value="SDY_2447"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2447"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="74" mass="8425" checksum="3DDF0CCF31A0832A" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITRQRLLHFESGVISHYQRAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E56</accession>
    <name>Q32E56_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E56"/>
    <dbReference type="STRING" id="300267.SDY_2322"/>
    <dbReference type="EnsemblBacteria" id="ABB62399">
        <property type="protein sequence ID" value="ABB62399"/>
        <property type="gene ID" value="SDY_2322"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2322"/>
    <dbReference type="HOGENOM" id="CLU_088250_1_0_6"/>
    <dbReference type="OMA" id="PVNVQEK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="152" mass="16405" checksum="450B872CD7D404BA" modified="2005-12-06" version="1">MIVRETNDEAWQAAERLISHLDDETIAKAQAAFARTDSVGQQRMAALHNGKRDNLEISPNLWAGVGLVRSGAGTALVGDGPTVAARINEYAALGIDSFVLSGYPHLEEAYRVGELLFPHLDVAIPEIPQPQPLNPQGEAVANDFIPRRVAQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EA0</accession>
    <name>THIM_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="1">2.7.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-methyl-5-beta-hydroxyethylthiazole kinase</fullName>
            <shortName evidence="1">TH kinase</shortName>
            <shortName evidence="1">Thz kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiM</name>
        <name type="ordered locus">SDY_2278</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Thz kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001195629.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403846.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EA0"/>
    <dbReference type="SMR" id="Q32EA0"/>
    <dbReference type="STRING" id="300267.SDY_2278"/>
    <dbReference type="EnsemblBacteria" id="ABB62355">
        <property type="protein sequence ID" value="ABB62355"/>
        <property type="gene ID" value="SDY_2278"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2278"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2751"/>
    <dbReference type="HOGENOM" id="CLU_019943_0_1_6"/>
    <dbReference type="OMA" id="KRPLVHN"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000513">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00694">
        <property type="entry name" value="thiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000021528" description="Hydroxyethylthiazole kinase">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00228"/>
        </source>
    </evidence>
    <sequence length="262" mass="27420" checksum="06050CC9217E725F" modified="2005-12-06" version="1">MQVDLLSSAQSAHTLHLFHQHSPLVHCMTNDVVQTFTANTLLALGASPAMVIETEEASQFAAIASALLINVDTLTQPRAQAMRAAVEQAKSSQTPWTLDPVAVGALDYRRHFCHELLSFKPAAIRGNASEIMALAGIANGGRGVDTTDAAANAIPAAQTLARETGAIVVVTGVMDYVTDGRRTVGIHGGDPLMAKVVGTGCALSAVVAACCALPGDMLENVASACHWMKQAGERAVARSEGPGSFVPHFLDALWQLTQEVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EA8</accession>
    <name>Q32EA8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EA8"/>
    <dbReference type="STRING" id="300267.SDY_2270"/>
    <dbReference type="EnsemblBacteria" id="ABB62347">
        <property type="protein sequence ID" value="ABB62347"/>
        <property type="gene ID" value="SDY_2270"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2270"/>
    <dbReference type="HOGENOM" id="CLU_057069_0_0_6"/>
    <dbReference type="OMA" id="FVKVNYP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="374" mass="40907" checksum="C2E36FB4B0CA76C1" modified="2005-12-06" version="1">MIARKRRARTIHSRYPIGIYGSIVMTDIAQLLGKDADNLLQHRCMTIPSDQLYLPGHDYVDRVMIDNNRPPAVLRNMQTLYNTGRLAGTGYLSILPVDQGVEHSAGASFAANPLYFDPKNIVELAIEAGCNCVASTYGVLASVSRRYAHRIPFLVKLNHNETLSYPNTYDQTLYASVEQAFNMGAVAVGATIYFGSEESRRQIEEISAAFERAHELGMVTVLWAYLRNSAFKKDGVDYHVSADLTGQANHLAATIGADIVKQKMAENNGGYKAINYGYTDDRVYSKLTSENPIDLVRYQLANCYMGRAGLINSGGAAGGETDLSDAVRTAVINKRAGGMGLILGRKAFKKSMADGVKLINAVQDVYLDSKITIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EF4</accession>
    <name>HIS6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="1">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ImGP synthase subunit HisF</fullName>
            <shortName evidence="1">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisF</name>
        <name type="ordered locus">SDY_2216</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000880181.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403792.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EF4"/>
    <dbReference type="SMR" id="Q32EF4"/>
    <dbReference type="STRING" id="300267.SDY_2216"/>
    <dbReference type="EnsemblBacteria" id="ABB62301">
        <property type="protein sequence ID" value="ABB62301"/>
        <property type="gene ID" value="SDY_2216"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2216"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2680"/>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_6"/>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000142228" description="Imidazole glycerol phosphate synthase subunit HisF">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <sequence length="258" mass="28468" checksum="E3FE4A2B4A21BEA1" modified="2005-12-06" version="1">MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHIPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EH5</accession>
    <name>Q32EH5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-methyl-adenine DNA glycosylase II, inducible</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">alkA</name>
        <name evidence="6" type="ordered locus">SDY_2194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000288354.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403771.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EH5"/>
    <dbReference type="STRING" id="300267.SDY_2194"/>
    <dbReference type="EnsemblBacteria" id="ABB62280">
        <property type="protein sequence ID" value="ABB62280"/>
        <property type="gene ID" value="SDY_2194"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2194"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2652"/>
    <dbReference type="HOGENOM" id="CLU_000445_72_3_6"/>
    <dbReference type="OMA" id="YLWRSIE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000035">
        <property type="entry name" value="Alkylbase_DNA_glycsylse_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00516">
        <property type="entry name" value="ALKYLBASE_DNA_GLYCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlkA_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="ENDO3c" evidence="4">
        <location>
            <begin position="130"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="282" mass="31374" checksum="D905DFDD13F99530" modified="2005-12-06" version="1">MYTLNWQPPYDWSWMLGFLAARAVNGVETVADDYYARSLAVGEYRGVVTAIPDIARHTLHINLSAGLEPVAAECLAKMSRLFDLQCNPQIVNGALGKLGVARPGLRLPGSVDAFEQGVRAILGQLVSVAMAAKLTAKVAQLYGERLDDFPEYICFPTPQRLAAADPQALKALGMPLKRAEALIHLANAALEGTLPMTIPGDVEQAMKTLQTFPGIGRWTANYFALRGWQAKDVFLPDDYLIKQRFPGMTPAQIRRYAERWKPWRSYALLHIWYTEGWQPDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ES4</accession>
    <name>Q32ES4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yceB</name>
        <name evidence="1" type="ordered locus">SDY_2090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022016.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403672.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ES4"/>
    <dbReference type="STRING" id="300267.SDY_2090"/>
    <dbReference type="EnsemblBacteria" id="ABB62181">
        <property type="protein sequence ID" value="ABB62181"/>
        <property type="gene ID" value="SDY_2090"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2090"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2515"/>
    <dbReference type="HOGENOM" id="CLU_105009_0_0_6"/>
    <dbReference type="OMA" id="HNDYQKQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010835">
        <property type="entry name" value="DUF1439"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07273">
        <property type="entry name" value="DUF1439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="186" mass="20611" checksum="EEB0D7007B2ADA3F" modified="2005-12-06" version="1">MNKFLFAAALIVSGLLVGCNQLTQYTITEQEINQSLAKHNNFSKDIGLPGVADAHIVLTNLTSQIGREEPNKVTLTGDANLDMNSLFGSQKATMKLKLKALPVFDKEKGAIFLKEMEVVDATVQPEKMQTVMQTLLPYLNQALRNYFNQQPAYVLREDGSQGEAMAKKLAKRIEVKPGEIVIPFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ES8</accession>
    <name>Q32ES8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylation of N-terminal alanine of 30S ribosomal subunit protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimJ</name>
        <name evidence="2" type="ordered locus">SDY_2086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000468184.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403668.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ES8"/>
    <dbReference type="STRING" id="300267.SDY_2086"/>
    <dbReference type="EnsemblBacteria" id="ABB62177">
        <property type="protein sequence ID" value="ABB62177"/>
        <property type="gene ID" value="SDY_2086"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2086"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2508"/>
    <dbReference type="HOGENOM" id="CLU_013985_40_1_6"/>
    <dbReference type="OMA" id="AACIPDN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="194" mass="22670" checksum="1DCA9E7D1C06AF65" modified="2005-12-06" version="1">MFGYRSNVPKVRLTTDRLVVRLVHDRDAWRLADYYAENRHFLKPWEPVRDESHCYPSGWQARLGMINEFHKQGSAFYFGLFDPDEKEIIGVANFSNVVRGSFHACYLGYSIGQKWQGKGLMFEALTAAIRYIQRTQHIHRIMANYMPHNKRSGDLLARLGFEKEGYAKDYLLIDGQWRDHVLTALTTPDWTPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EU8</accession>
    <name>Q32EU8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal RNA subunit accumulation protein YceD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">23S rRNA accumulation protein YceD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yceD</name>
        <name evidence="5" type="ordered locus">SDY_2062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in synthesis, processing and/or stability of 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DUF177 domain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001174481.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403648.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EU8"/>
    <dbReference type="STRING" id="300267.SDY_2062"/>
    <dbReference type="EnsemblBacteria" id="ABB62157">
        <property type="protein sequence ID" value="ABB62157"/>
        <property type="gene ID" value="SDY_2062"/>
    </dbReference>
    <dbReference type="GeneID" id="67414281"/>
    <dbReference type="KEGG" id="sdy:SDY_2062"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2477"/>
    <dbReference type="HOGENOM" id="CLU_094127_2_1_6"/>
    <dbReference type="OMA" id="TLLCQRC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039255">
        <property type="entry name" value="YceD_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38099">
        <property type="entry name" value="PTHR38099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="173" mass="19315" checksum="B9A75B15F13BF6C8" modified="2005-12-06" version="1">MQKVKLPLTLDPVRTAQKRLDYQGIYTPDQVERVAESVVSVDSDVECSMSFAIDNQRLAVLNGDAKVTVTLECQRCGKPFTHQVYTTYCFSPVRSDEQAEALPEAYEPIEVNEFGEIDLLAMVEDEIILALPVVPVHDSEHCEVSEADMVFGELPEEAQKPNPFAVLASLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EV3</accession>
    <name>Q32EV3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="4">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fabG</name>
        <name evidence="5" type="ordered locus">SDY_2057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001008530.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403643.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EV3"/>
    <dbReference type="STRING" id="300267.SDY_2057"/>
    <dbReference type="EnsemblBacteria" id="ABB62152">
        <property type="protein sequence ID" value="ABB62152"/>
        <property type="gene ID" value="SDY_2057"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2057"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2472"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_6"/>
    <dbReference type="OMA" id="KMPERDY"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="151"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="244" mass="25576" checksum="28A0432A6377AFD0" modified="2005-12-06" version="1">MNFEGKIALVTGASRGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLMLNVTDLASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSKAVMRAMMKKRHGRIITIGSVVGTMGNGGQANYAAAKAGLIGFSKSLAREVASRGITVNVVAPGFIETDMTRALSDDQRAGILAQVPAGRLGGAQEIANAVAFLASDEAAYITGETLHVNGGMYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EV5</accession>
    <name>Q32EV5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fabF</name>
        <name evidence="14" type="ordered locus">SDY_2055</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000044689.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403641.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EV5"/>
    <dbReference type="STRING" id="300267.SDY_2055"/>
    <dbReference type="EnsemblBacteria" id="ABB62150">
        <property type="protein sequence ID" value="ABB62150"/>
        <property type="gene ID" value="SDY_2055"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2055"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2470"/>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_6"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="6"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB62150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="413" mass="43016" checksum="A1E36029FE55C72A" modified="2005-12-06" version="1">MSKRRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAGLVKDFNCEDIISRKEQRKTDAFIQYGIVAGVQAMQDSGLEITEENATRIGAAIGSGIGGLGLIEENHTSLMNGGPRKISPFFVPSTIVNMVAGHLTIMYGLRGPSISIATACTSGVHNIGHAARIIAYGDADVMVAGGAEKASTPLGVGGFGAARALSTRNDNPQAASRPWDKERDGFVLGDGAGMLVLEEYEHAKKRGAKIYAELVGFGMSSDAYHMTSPPENGAGAALAMANALRDAGIEASQIGYVNAHGTSTPAGDKAEAQAVKTIFGEAASRVLVSSTKSMTGHLLGAAGAVESIYSILALRDQAVPPTINLDNPDEGCDLDFVPHEARQVSGMEYTLCNSFGFGGTNGSLIFKKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EX9</accession>
    <name>NAGK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-D-glucosamine kinase</fullName>
            <ecNumber evidence="1">2.7.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GlcNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nagK</name>
        <name type="ordered locus">SDY_2031</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="2.7.1.59"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family. NagK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.59" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000291270.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403617.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EX9"/>
    <dbReference type="SMR" id="Q32EX9"/>
    <dbReference type="STRING" id="300267.SDY_2031"/>
    <dbReference type="EnsemblBacteria" id="ABB62126">
        <property type="protein sequence ID" value="ABB62126"/>
        <property type="gene ID" value="SDY_2031"/>
    </dbReference>
    <dbReference type="GeneID" id="66670615"/>
    <dbReference type="KEGG" id="sdy:SDY_2031"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2444"/>
    <dbReference type="HOGENOM" id="CLU_036604_0_3_6"/>
    <dbReference type="OMA" id="VNVPGWR"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01271">
        <property type="entry name" value="GlcNAc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023505">
        <property type="entry name" value="N-acetyl-D-glucosamine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000270116" description="N-acetyl-D-glucosamine kinase">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="4"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01271"/>
        </source>
    </evidence>
    <sequence length="303" mass="33043" checksum="A857E63925894BBD" modified="2005-12-06" version="1">MYYGFDIGGTKIALGVFDSGRQLQWEKRVPTPRDSYDAFLDAVCELVAEADQRFGCKGSVGIGIPGMPETEDGTLYAANVPAASGKPLRADLSARLDRDVRLDNDANCFALSEAWDDEFTQYPLVMGLILGTGVGGGLIFNGKPITGKSYITGEFGHMRLPVDALTMMGLDFPLRRCGCGQHGCIENYLSGRGFAWLYQHYYHQPLQAPEIIALYDQGDEQARAHVERYLDLLAVCLGNILTIVDPDLVVIGGGLSNFPAITTQLADRLPRHLLPVARVPRIERARHGDAGGMRGAAFLHLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EY6</accession>
    <name>Q32EY6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycfD</name>
        <name evidence="3" type="ordered locus">SDY_2024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403610.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EY6"/>
    <dbReference type="STRING" id="300267.SDY_2024"/>
    <dbReference type="EnsemblBacteria" id="ABB62119">
        <property type="protein sequence ID" value="ABB62119"/>
        <property type="gene ID" value="SDY_2024"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2024"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2437"/>
    <dbReference type="HOGENOM" id="CLU_039125_0_0_6"/>
    <dbReference type="OMA" id="VDQFVPE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="JmjC_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="PTHR13096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="Cupin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="95"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="376" mass="42953" checksum="1BDA1F82B952694D" modified="2005-12-06" version="1">MLNMEYQLTLNWPDFLERHWQKRPVVLKRGFNNFIDPISPDELAGLAMESEVDSRLVSHQDGKWQVSHGPFESYDHLGETNWSLLVQAVNHWHEPTAALMRPFRELPDWRIDDLMISFSVPGGGVGPHLDQYDVFIIQGTGRRRWRVGEKLQMKQHCPHPDLLQVDPFEAIIDEELEPSDILYIPPGFPHEGYALENAMNYSVGFRAPNTRELISGFADYVLQRELGGNYYSDPDVPPRAHPADVLPQEMDKLREMMLELINQPEHFKQWFGEFISQSRHELDIAPPEPPYQPDEIYDALKQGDVLVRLGGLRVLRIGDDVYANGEKIDSPHRPALDALASNIALTAENFGDALEDPSFLAMLAALVNSGYWFFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F00</accession>
    <name>Q32F00_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F00"/>
    <dbReference type="STRING" id="300267.SDY_2010"/>
    <dbReference type="EnsemblBacteria" id="ABB62105">
        <property type="protein sequence ID" value="ABB62105"/>
        <property type="gene ID" value="SDY_2010"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2010"/>
    <dbReference type="HOGENOM" id="CLU_2571966_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="9258" checksum="3CD13411545CF547" modified="2005-12-06" version="1">MRFSTIVSVVILVWGISPRQPSGKNIIRWLLKKRTNGSVRYCQYTSYSLNSRENICGIVKFVSVTNILVICHSKWSANLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F18</accession>
    <name>Q32F18_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403578.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F18"/>
    <dbReference type="STRING" id="300267.SDY_1987"/>
    <dbReference type="EnsemblBacteria" id="ABB62087">
        <property type="protein sequence ID" value="ABB62087"/>
        <property type="gene ID" value="SDY_1987"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1987"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2398"/>
    <dbReference type="HOGENOM" id="CLU_160612_0_0_6"/>
    <dbReference type="OMA" id="GWDEHTS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009950">
        <property type="entry name" value="DUF1480"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07351">
        <property type="entry name" value="DUF1480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9329" checksum="26AE60AF42D49C8A" modified="2005-12-06" version="1">MESTKMKTSVRIGAFEIDDGELHGESPGDRTLTIPCKSDPDLCMQLDAWDAETSIPALLNGEHSVLYRTRYDQQSDAWIMRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F33</accession>
    <name>Q32F33_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Uncharacterized protein YebO</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SDY_1972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001014738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403563.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F33"/>
    <dbReference type="STRING" id="300267.SDY_1972"/>
    <dbReference type="EnsemblBacteria" id="ABB62072">
        <property type="protein sequence ID" value="ABB62072"/>
        <property type="gene ID" value="SDY_1972"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1972"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2381"/>
    <dbReference type="HOGENOM" id="CLU_165389_1_0_6"/>
    <dbReference type="OMA" id="VLWFFVN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025594">
        <property type="entry name" value="YebO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13974">
        <property type="entry name" value="YebO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="95" mass="10734" checksum="4F5557A1EFE3C7F7" modified="2005-12-06" version="1">MNGVVNSGVMNIASLVVSVVVLLIGLILWFFINRASSRTNEQIELLEALLDQQKRQNALLRRLCEANEPEKADKKTIESQKSVEDEDIIRLVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F47</accession>
    <name>Q32F47_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403549.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F47"/>
    <dbReference type="STRING" id="300267.SDY_1957"/>
    <dbReference type="EnsemblBacteria" id="ABB62058">
        <property type="protein sequence ID" value="ABB62058"/>
        <property type="gene ID" value="SDY_1957"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1957"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2364"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_4_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FCD" evidence="4">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="145" mass="17127" checksum="62241D683C8E47D1" modified="2005-12-06" version="1">MGKRQLDEINRIRYELELMAVALAVENLTPQDLAELQELLEKLQQAQEKGDMEQIINVNRLFRLAIYHRSNMPILCEMIEQLWVRMGPGLHYLYEAINPAELREHIENYHLLLAALKAKDKEGCRYCLAEIMQQNIAILYQQYNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FB3</accession>
    <name>PURR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional repressor PurR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pur regulon repressor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Purine nucleotide synthesis repressor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purR</name>
        <name type="ordered locus">SDY_1884</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.</text>
    </comment>
    <comment type="pathway">
        <text>Purine metabolism; purine nucleotide biosynthesis [regulation].</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000190986.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403483.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FB3"/>
    <dbReference type="SMR" id="Q32FB3"/>
    <dbReference type="STRING" id="300267.SDY_1884"/>
    <dbReference type="EnsemblBacteria" id="ABB61992">
        <property type="protein sequence ID" value="ABB61992"/>
        <property type="gene ID" value="SDY_1884"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1884"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2267"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_6"/>
    <dbReference type="OMA" id="ARWVGPP"/>
    <dbReference type="UniPathway" id="UPA00488"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01277">
        <property type="entry name" value="HTH_type_PurR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023588">
        <property type="entry name" value="Tscrpt_reg_HTH_PurR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00356">
        <property type="entry name" value="HTH_LACI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000279669" description="HTH-type transcriptional repressor PurR">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="4"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>hypoxanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>hypoxanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>hypoxanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>hypoxanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>hypoxanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01277"/>
        </source>
    </evidence>
    <sequence length="341" mass="38174" checksum="588BAFEA6C72F39C" modified="2005-12-06" version="1">MATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPKSWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FE7</accession>
    <name>Q32FE7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FE7"/>
    <dbReference type="STRING" id="300267.SDY_1849"/>
    <dbReference type="EnsemblBacteria" id="ABB61958">
        <property type="protein sequence ID" value="ABB61958"/>
        <property type="gene ID" value="SDY_1849"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1849"/>
    <dbReference type="HOGENOM" id="CLU_147992_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019690">
        <property type="entry name" value="DUF2569"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10754">
        <property type="entry name" value="DUF2569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="116" mass="13221" checksum="36808F7A48EC6CC2" modified="2005-12-06" version="1">MLLYTAALSSPQTFQTLGAQALTTQILWGVSFITAIAMWYYTLWLTIAFFKRRRCVPKHYIIWLLISVLLAVKAFAFSPVEDSIAVRQLLFTLLATALIVPYFKRSSRVKATFVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FQ7</accession>
    <name>Q32FQ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FQ7"/>
    <dbReference type="EnsemblBacteria" id="ABB61848">
        <property type="protein sequence ID" value="ABB61848"/>
        <property type="gene ID" value="SDY_1728"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1728"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9128" checksum="5E48FA57195F7E1F" modified="2005-12-06" version="1">MTVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITNSFIWAMTLSSIAASTRAMTSSRCDILSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FT9</accession>
    <name>Q32FT9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yeaQ</name>
        <name evidence="8" type="ordered locus">SDY_1695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000512153.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403307.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FT9"/>
    <dbReference type="SMR" id="Q32FT9"/>
    <dbReference type="STRING" id="300267.SDY_1695"/>
    <dbReference type="EnsemblBacteria" id="ABB61816">
        <property type="protein sequence ID" value="ABB61816"/>
        <property type="gene ID" value="SDY_1695"/>
    </dbReference>
    <dbReference type="GeneID" id="66674316"/>
    <dbReference type="KEGG" id="sdy:SDY_1695"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2044"/>
    <dbReference type="HOGENOM" id="CLU_160040_2_3_6"/>
    <dbReference type="OMA" id="GWIMTIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="8671" checksum="C2C625D81CFFAAD3" modified="2005-12-06" version="1">MGILSWIIFGLIAGILAKWIMPGKDGGGFFMTILLGIVGAVVGGWISTLFGFGKVDGFNFGSFVVAVIGAIVVLFIYRKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FX0</accession>
    <name>Q32FX0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FX0"/>
    <dbReference type="EnsemblBacteria" id="ABB61785">
        <property type="protein sequence ID" value="ABB61785"/>
        <property type="gene ID" value="SDY_1664"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1664"/>
    <dbReference type="HOGENOM" id="CLU_816107_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="340" mass="38202" checksum="78203D8095EA9FDD" modified="2005-12-06" version="1">MASLDLSYLDLSELPPIPSTVNTLNLENNCLTCLDFADNASLVNINLSFNKIKTITFPNESKLENIYINHNDLESLDFKNQNSLINLEAQNNNLTKINISESYKLKFLNLDYNKLSSLDLSRQESLIELSAHHNMITDLILHNHPRMKKITLNDNHIAHLNTKTTTKLEYLNLSNNNLLPTNDIVQLISSKHLWHVLVNGINNDSLAQMQYWTAVGNIIDDTNEVTIDLSYNLAITNIDTSDEHLAEVSDNSEGNYIKDNDSVMLPTYYLVYDGDFKVLAWLPFPSDVLPAPLLKAWCVTAKALPDISAISALIAVKHGNYSSLTPPLSPVSTRKSLIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G38</accession>
    <name>Q32G38_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydeJ</name>
        <name evidence="2" type="ordered locus">SDY_1588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001024558.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403208.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G38"/>
    <dbReference type="STRING" id="300267.SDY_1588"/>
    <dbReference type="EnsemblBacteria" id="ABB61717">
        <property type="protein sequence ID" value="ABB61717"/>
        <property type="gene ID" value="SDY_1588"/>
    </dbReference>
    <dbReference type="GeneID" id="58391788"/>
    <dbReference type="KEGG" id="sdy:SDY_1588"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1907"/>
    <dbReference type="HOGENOM" id="CLU_030805_1_1_6"/>
    <dbReference type="OMA" id="CFAWAFR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="172" mass="18265" checksum="AD17EA92CA6919BC" modified="2005-12-06" version="1">MNINKDKIVQLADTDTIENLTSALSQRLIADQLRLTTAESCTGGKLASALCAAEDTPKFYGAGFVTFTDQAKMKILSVSQQSLERYSAVSEKVAAEMATGAIERADADVSIAITGYGGPEGGEDGTPAGTVWFAWHIKGQNYTAVMHFAGDCETVLALAVRFALAQLLQLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GC1</accession>
    <name>Q32GC1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403125.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GC1"/>
    <dbReference type="STRING" id="300267.SDY_1495"/>
    <dbReference type="EnsemblBacteria" id="ABB61634">
        <property type="protein sequence ID" value="ABB61634"/>
        <property type="gene ID" value="SDY_1495"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1495"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1784"/>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_6"/>
    <dbReference type="OMA" id="TVDHLYH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="214" mass="23298" checksum="0B1AC2C424E1D267" modified="2005-12-06" version="1">MTEDGERTFVTNRNGSLWKLNIDDVDFARFSQAKLLSLASIFNSPLLDGKALTEIFTQAKARQMIICADMIKPRLNETLDDICEALSYVDYLFPNYAEAKLLTGKETLDEIADCFFACGVKTVVIKTGKDGCFIKRGDMTMKVPAVVGITAIDTIGAGDNFASGFIAALLEGKNLRECARFANATAAISVLSVGATTGVKNRKLVEQLLEEYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GL5</accession>
    <name>Q32GL5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1395</name>
        <name evidence="3" type="ordered locus">SDY_1992</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403031.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403582.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_1395"/>
    <dbReference type="EnsemblBacteria" id="ABB61540">
        <property type="protein sequence ID" value="ABB61540"/>
        <property type="gene ID" value="SDY_1395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62091">
        <property type="protein sequence ID" value="ABB62091"/>
        <property type="gene ID" value="SDY_1992"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1395"/>
    <dbReference type="KEGG" id="sdy:SDY_1992"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1656"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_3_6"/>
    <dbReference type="OMA" id="WIEVVYN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="106"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32339" checksum="298CABE50B222517" modified="2005-12-06" version="1">MVTLCHVFGVHRSSYRYWKNRPEKPDGRRAVLRSQVLELHGISHGSAGARSIATMATRRGYQMGRWLAGRLMKELGLVSCQQPTHRYKRGGHEHVAIPNYLERQFAVTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKPGGVMFHSDQGSHYTSRQFRQLLWRYQIRQSMSRRGNCWDNSPMERFFRSLKNEWMPVVGYVSFSEAAHAITDYIVGYYSALRPHEYNGGLPPNESENRYWKNSNSVASFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GY0</accession>
    <name>Q32GY0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GY0"/>
    <dbReference type="EnsemblBacteria" id="ABB61425">
        <property type="protein sequence ID" value="ABB61425"/>
        <property type="gene ID" value="SDY_1277"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1277"/>
    <dbReference type="HOGENOM" id="CLU_2716350_0_0_6"/>
    <dbReference type="OMA" id="TIWNGSI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8525" checksum="17C1334AB1C57C1E" modified="2005-12-06" version="1">MSNNLNECDDTIWNGSILGYWLKHTHTRKELLLICRVVSRFTSVRVGILQHREKSHNFYEITVLTMGNDKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HB7</accession>
    <name>Q32HB7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protease II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptrB</name>
        <name evidence="5" type="ordered locus">SDY_1131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001134771.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402779.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HB7"/>
    <dbReference type="STRING" id="300267.SDY_1131"/>
    <dbReference type="ESTHER" id="shifl-PTRB">
        <property type="family name" value="S9N_PREPL_Peptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.010"/>
    <dbReference type="EnsemblBacteria" id="ABB61288">
        <property type="protein sequence ID" value="ABB61288"/>
        <property type="gene ID" value="SDY_1131"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1131"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1333"/>
    <dbReference type="HOGENOM" id="CLU_011290_0_1_6"/>
    <dbReference type="OMA" id="NMGAGHG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="463"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="686" mass="79340" checksum="88937189FA042940" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HJ9</accession>
    <name>Q32HJ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HJ9"/>
    <dbReference type="EnsemblBacteria" id="ABB61206">
        <property type="protein sequence ID" value="ABB61206"/>
        <property type="gene ID" value="SDY_1041"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1041"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="76" mass="8746" checksum="95351CABA94306AB" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITRFFLYSLPLRKNYLFVQKMSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HN0</accession>
    <name>Q32HN0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative structural protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yeeU</name>
        <name evidence="1" type="ordered locus">SDY_1010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001285603.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402666.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HN0"/>
    <dbReference type="STRING" id="300267.SDY_1010"/>
    <dbReference type="EnsemblBacteria" id="ABB61175">
        <property type="protein sequence ID" value="ABB61175"/>
        <property type="gene ID" value="SDY_1010"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1010"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1178"/>
    <dbReference type="HOGENOM" id="CLU_144696_0_0_6"/>
    <dbReference type="OMA" id="NKDRPWW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051495">
        <property type="term" value="P:positive regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009320">
        <property type="entry name" value="Antitoxin_CbeA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038025">
        <property type="entry name" value="CbeA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06154">
        <property type="entry name" value="CbeA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143737">
        <property type="entry name" value="SSF143737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="13822" checksum="3E93A43D4F4C5B9F" modified="2005-12-06" version="1">MSDTLPGTTLPDDNKDRPWWRLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HQ1</accession>
    <name>RUTC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-aminoacrylate deaminase RutC</fullName>
            <shortName evidence="1">3-AA deaminase</shortName>
            <ecNumber evidence="1">3.5.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rutC</name>
        <name type="ordered locus">SDY_0985</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pyrimidine catabolism. Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously. RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(Z)-3-aminoacrylate + H(+) + H2O = 3-oxopropanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:34947"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:59894"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001126780.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402645.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HQ1"/>
    <dbReference type="SMR" id="Q32HQ1"/>
    <dbReference type="STRING" id="300267.SDY_0985"/>
    <dbReference type="EnsemblBacteria" id="ABB61154">
        <property type="protein sequence ID" value="ABB61154"/>
        <property type="gene ID" value="SDY_0985"/>
    </dbReference>
    <dbReference type="GeneID" id="66670712"/>
    <dbReference type="KEGG" id="sdy:SDY_0985"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1145"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_6"/>
    <dbReference type="OMA" id="MPKTIIT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00831">
        <property type="entry name" value="RutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019898">
        <property type="entry name" value="RutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03610">
        <property type="entry name" value="RutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000402765" description="3-aminoacrylate deaminase RutC">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00831"/>
        </source>
    </evidence>
    <sequence length="128" mass="13763" checksum="7D5FC2374597D907" modified="2005-12-06" version="1">MPKSVIIPAGSSAPLAPFVPGTLADGVVYVSGTLAFDQHNNVLFADDPKAQTRHVLETIRKVIETAGGTMADVTFNSIFITDWKNYAAINEIYAEFFPGDKPARFCIQCGLVKPDALVEIATIAHIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HU1</accession>
    <name>Q32HU1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402605.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HU1"/>
    <dbReference type="STRING" id="300267.SDY_0940"/>
    <dbReference type="EnsemblBacteria" id="ABB61114">
        <property type="protein sequence ID" value="ABB61114"/>
        <property type="gene ID" value="SDY_0940"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0940"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1088"/>
    <dbReference type="HOGENOM" id="CLU_112567_0_1_6"/>
    <dbReference type="OMA" id="MVMDRCP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="36"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="164" mass="17764" checksum="EDA9DBFCFC63572A" modified="2005-12-06" version="1">MLSFIRISCMVGMSALSYTLLNSLEEIMKETDIEGILTSTHTIALVGASDKPDRPSYRVMKYLLDQGYHVIPVSPKVAGKTLLGQQGYGTLADVPEKVDMVDVFRNSEAAWGVAQEAIAIGAKTLWMQLGVINEQAAVLARDAGLNVVMDRCPAIEIPRLGLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HY9</accession>
    <name>Q32HY9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yejO</name>
        <name evidence="2" type="ordered locus">SDY_0889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402557.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HY9"/>
    <dbReference type="STRING" id="300267.SDY_0889"/>
    <dbReference type="EnsemblBacteria" id="ABB61066">
        <property type="protein sequence ID" value="ABB61066"/>
        <property type="gene ID" value="SDY_0889"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0889"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1030"/>
    <dbReference type="HOGENOM" id="CLU_002318_0_0_6"/>
    <dbReference type="OMA" id="GAANEPT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030930">
        <property type="entry name" value="AIDA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005546">
        <property type="entry name" value="Autotransporte_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036709">
        <property type="entry name" value="Autotransporte_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006315">
        <property type="entry name" value="OM_autotransptr_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004899">
        <property type="entry name" value="Pertactin_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003991">
        <property type="entry name" value="Pertactin_virulence_factor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16168">
        <property type="entry name" value="AIDA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03797">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03212">
        <property type="entry name" value="Pertactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01484">
        <property type="entry name" value="PRTACTNFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00869">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103515">
        <property type="entry name" value="SSF103515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01414">
        <property type="entry name" value="autotrans_barl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04415">
        <property type="entry name" value="O_hepto_targRPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51208">
        <property type="entry name" value="AUTOTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autotransporter" evidence="1">
        <location>
            <begin position="416"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="684" mass="72557" checksum="62B785A75C46D133" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I11</accession>
    <name>MQO_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable malate:quinone oxidoreductase</fullName>
            <ecNumber evidence="1">1.1.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">MQO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Malate dehydrogenase [quinone]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mqo</name>
        <name type="ordered locus">SDY_0866</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-malate + a quinone = a quinol + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:46012"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MQO family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000758085.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402535.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I11"/>
    <dbReference type="STRING" id="300267.SDY_0866"/>
    <dbReference type="EnsemblBacteria" id="ABB61044">
        <property type="protein sequence ID" value="ABB61044"/>
        <property type="gene ID" value="SDY_0866"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0866"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1000"/>
    <dbReference type="HOGENOM" id="CLU_028151_0_0_6"/>
    <dbReference type="OMA" id="PHLDTRW"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052589">
        <property type="term" value="F:malate dehydrogenase (menaquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008924">
        <property type="term" value="F:malate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00212">
        <property type="entry name" value="MQO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006231">
        <property type="entry name" value="MQO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06039">
        <property type="entry name" value="Mqo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01320">
        <property type="entry name" value="mal_quin_oxido"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="chain" id="PRO_1000023815" description="Probable malate:quinone oxidoreductase">
        <location>
            <begin position="1"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="548" mass="60274" checksum="36940168A0F085CE" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I24</accession>
    <name>Q32I24_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_0853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001104490.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402522.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I24"/>
    <dbReference type="STRING" id="300267.SDY_0853"/>
    <dbReference type="EnsemblBacteria" id="ABB61031">
        <property type="protein sequence ID" value="ABB61031"/>
        <property type="gene ID" value="SDY_0853"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0853"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.987"/>
    <dbReference type="HOGENOM" id="CLU_029249_0_0_6"/>
    <dbReference type="OMA" id="SVWKLFV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018748">
        <property type="entry name" value="DUF2300_secreted"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10062">
        <property type="entry name" value="DUF2300"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221114" evidence="1">
        <location>
            <begin position="20"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2300" evidence="3">
        <location>
            <begin position="84"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="SpoIID" evidence="2">
        <location>
            <begin position="312"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2300" evidence="3">
        <location>
            <begin position="412"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="549" mass="61488" checksum="6B97A897A3CB9D2D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IC7</accession>
    <name>Q32IC7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutaredoxin1 redox coenzyme for glutathione-dependent ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">grxA</name>
        <name evidence="6" type="ordered locus">SDY_0746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001195231.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402419.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IC7"/>
    <dbReference type="SMR" id="Q32IC7"/>
    <dbReference type="STRING" id="300267.SDY_0746"/>
    <dbReference type="EnsemblBacteria" id="ABB60930">
        <property type="protein sequence ID" value="ABB60930"/>
        <property type="gene ID" value="SDY_0746"/>
    </dbReference>
    <dbReference type="GeneID" id="58460670"/>
    <dbReference type="KEGG" id="sdy:SDY_0746"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.860"/>
    <dbReference type="HOGENOM" id="CLU_026126_7_3_6"/>
    <dbReference type="OMA" id="VGGCTEF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011902">
        <property type="entry name" value="GRXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02183">
        <property type="entry name" value="GRXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="85" mass="9695" checksum="8C3C15A473ED2041" modified="2005-12-06" version="1">MQTVIFGRPGCPYCVRAKDLAEKLSNERDDFQYQYVDIRAEGITKEDLQQKAGKPVETVPQIFVDQQHIGGYTDFAAWVKENLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IF6</accession>
    <name>Q32IF6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IF6"/>
    <dbReference type="EnsemblBacteria" id="ABB60901">
        <property type="protein sequence ID" value="ABB60901"/>
        <property type="gene ID" value="SDY_0717"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0717"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="74" mass="8431" checksum="998CF730460E915E" modified="2005-12-06" version="1">MAVTAAKSVMAFRVMTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITNSGYLSNIQRYNPLWRELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IK5</accession>
    <name>Q32IK5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="4">1.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sucA</name>
        <name evidence="8" type="ordered locus">SDY_0664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001181467.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402341.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IK5"/>
    <dbReference type="STRING" id="300267.SDY_0664"/>
    <dbReference type="EnsemblBacteria" id="ABB60852">
        <property type="protein sequence ID" value="ABB60852"/>
        <property type="gene ID" value="SDY_0664"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0664"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.775"/>
    <dbReference type="HOGENOM" id="CLU_004709_1_0_6"/>
    <dbReference type="OMA" id="RDSYCRT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="591"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="933" mass="105009" checksum="069127FF38389B37" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JD7</accession>
    <name>AROL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase 2</fullName>
            <shortName evidence="2">SK 2</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroL</name>
        <name type="ordered locus">SDY_0355</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The LID domain closes over the active site upon ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family. AroL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000193380.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402059.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JD7"/>
    <dbReference type="SMR" id="Q32JD7"/>
    <dbReference type="STRING" id="300267.SDY_0355"/>
    <dbReference type="EnsemblBacteria" id="ABB60570">
        <property type="protein sequence ID" value="ABB60570"/>
        <property type="gene ID" value="SDY_0355"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0355"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.416"/>
    <dbReference type="HOGENOM" id="CLU_057607_4_3_6"/>
    <dbReference type="OMA" id="DTDIFMQ"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01269">
        <property type="entry name" value="Shikimate_kinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027544">
        <property type="entry name" value="Shikimate_kinase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000237932" description="Shikimate kinase 2">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID domain">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01269"/>
        </source>
    </evidence>
    <sequence length="174" mass="19177" checksum="AD57D8719C32CE6E" modified="2007-01-23" version="3">MTQPLFLIGPRGCGKTTVGMALADLLNRRFVDTDQWLQSQLNMTVAEIVEREEWAGFRARETAALEAVTAPSTVIATGGGIILTEFNRHFMQNNGIVVYLCAPVSVLVNRLQAAPEEDLRPTLTGKPLSEEVQEVLEERDALYREVAHIIIDATNEPSQVISEIRSALAQTINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JG1</accession>
    <name>Q32JG1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Sec translocon accessory complex subunit YajC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">yajC</name>
        <name evidence="11" type="ordered locus">SDY_0327</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000007629.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402035.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JG1"/>
    <dbReference type="SMR" id="Q32JG1"/>
    <dbReference type="STRING" id="300267.SDY_0327"/>
    <dbReference type="EnsemblBacteria" id="ABB60546">
        <property type="protein sequence ID" value="ABB60546"/>
        <property type="gene ID" value="SDY_0327"/>
    </dbReference>
    <dbReference type="GeneID" id="67416520"/>
    <dbReference type="KEGG" id="sdy:SDY_0327"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.376"/>
    <dbReference type="HOGENOM" id="CLU_116157_2_1_6"/>
    <dbReference type="OMA" id="GMEMIIM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="110" mass="11887" checksum="8E90AF51F0205306" modified="2005-12-06" version="1">MSFFISDAVAATGAPAQGSPMSLILMLVVFGLIFYFMILRPQQKRTKEHKKLMDSIAKGDEVLTNGGLVGRVTKVAENGYIAIALNDTTEVVIKRDFVAAVLPKGTMKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JP0</accession>
    <name>Q32JP0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_0243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JP0"/>
    <dbReference type="EnsemblBacteria" id="ABB60467">
        <property type="protein sequence ID" value="ABB60467"/>
        <property type="gene ID" value="SDY_0243"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0243"/>
    <dbReference type="HOGENOM" id="CLU_036805_12_2_6"/>
    <dbReference type="OMA" id="ENTFELX"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="163" mass="18299" checksum="FCDF410306FB7060" modified="2005-12-06" version="1">MKNTCSTNWKHHPMDEKKLKALAAELAKGLKTEADLNQFSRMLTKLTVETALNAELTDHLGHEKNAPKSGSNTRNGYSSKTVLCDDGEIELNTPRDRENTFEPQLIKKHQTRITQMDSQILSLYAKGMTTREIVATFKEMYDADVSPTLISKVTDAVKEQASE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JT0</accession>
    <name>LPXD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase</fullName>
            <shortName evidence="1">UDP-3-O-(3-OHC14)-GlcN N-acyltransferase</shortName>
            <ecNumber evidence="1">2.3.1.191</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-3-O-(3-hydroxytetradecanoyl)glucosamine N-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxD</name>
        <name type="ordered locus">SDY_0195</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the N-acylation of UDP-3-O-(hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:17817"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:71573"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78847"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001139279.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401916.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JT0"/>
    <dbReference type="SMR" id="Q32JT0"/>
    <dbReference type="STRING" id="300267.SDY_0195"/>
    <dbReference type="EnsemblBacteria" id="ABB60427">
        <property type="protein sequence ID" value="ABB60427"/>
        <property type="gene ID" value="SDY_0195"/>
    </dbReference>
    <dbReference type="GeneID" id="66671533"/>
    <dbReference type="KEGG" id="sdy:SDY_0195"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.226"/>
    <dbReference type="HOGENOM" id="CLU_049865_0_1_6"/>
    <dbReference type="OMA" id="QIQIAHN"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103118">
        <property type="term" value="F:UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000264439" description="UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <sequence length="341" mass="36038" checksum="B0ADFED5B17C649D" modified="2005-12-06" version="1">MPSIRLADLAQQLDAELHGDGDIVITGVASMQSAQTGHITFMVNPKYREHLGLCQASAVVMTQDDLPFAKSAALVVKNPYLTYARMAQILDTTPQPAQNIAPSAVIDATAKLGNNVSIGANAVIESGVELGDNVIIGAGCFVGKNSKIGAGSRLWANVTIYHEIQIGQNCLIQSGTVVGADGFGYANDRGNWVKIPQIGRVIIGDRVEIGACTTIDRGALDDTIIGNGVIIDNQCQIAHNVVIGDNTAVAGGVIMAGSLKIGRYCMIGGASVINGHMEICDKVTVTGMGMVMRPITEPGVYSSGIPLQPNKVWRKTAALVMNIDDMSKRLKSLERKVNQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JZ3</accession>
    <name>Q32JZ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">7,8-dihydro-8-oxoguanine-triphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutT</name>
        <name evidence="7" type="ordered locus">SDY_0129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000736020.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401853.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JZ3"/>
    <dbReference type="STRING" id="300267.SDY_0129"/>
    <dbReference type="EnsemblBacteria" id="ABB60364">
        <property type="protein sequence ID" value="ABB60364"/>
        <property type="gene ID" value="SDY_0129"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0129"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.148"/>
    <dbReference type="HOGENOM" id="CLU_037162_19_2_6"/>
    <dbReference type="OMA" id="KLEYQFP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003561">
        <property type="entry name" value="Mutator_MutT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01401">
        <property type="entry name" value="MUTATORMUTT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00586">
        <property type="entry name" value="mutt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="8-oxo-dGTP binding" evidence="3">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>8-oxo-dGTP</name>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>8-oxo-dGTP</name>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>8-oxo-dGTP</name>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603561-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR603561-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="132" mass="15176" checksum="D4AB8E7333CC7763" modified="2005-12-06" version="1">MKKLQIAVGIIRNENNEIFITRRAADAHMANKLEFPGGKIEMGETPEQAVVRELQEEVGITPQHFSLFEKLEYEFPDRHITLWFWLVESWEGEPWGKEGQPGKWMSLVGLNADDFPPANEPVIAKLKRLYVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K43</accession>
    <name>RSMA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="1">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmA</name>
        <name evidence="1" type="synonym">ksgA</name>
        <name type="ordered locus">SDY_0076</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001065369.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401803.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K43"/>
    <dbReference type="SMR" id="Q32K43"/>
    <dbReference type="STRING" id="300267.SDY_0076"/>
    <dbReference type="EnsemblBacteria" id="ABB60314">
        <property type="protein sequence ID" value="ABB60314"/>
        <property type="gene ID" value="SDY_0076"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0076"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.86"/>
    <dbReference type="HOGENOM" id="CLU_041220_0_1_6"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000257346" description="Ribosomal RNA small subunit methyltransferase A">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <sequence length="273" mass="30429" checksum="88637E8B0E5E949B" modified="2005-12-06" version="1">MNNRVHQGHLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTFNFGELAEKMGQPLHVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKVYGRLSVMAQYYCNVIPVLEVPPSAFTPPPKVDSAVVRLVPHATMPHPVKDVRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTGMGIDPAMRAENISVAQYCQMANYLAENAPLQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K72</accession>
    <name>Q32K72_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Riboflavin kinase</fullName>
                <ecNumber evidence="12">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">FMN adenylyltransferase</fullName>
                <ecNumber evidence="12">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="12">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">ribF</name>
        <name evidence="14" type="ordered locus">SDY_0047</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="12"/>
    <dbReference type="EC" id="2.7.7.2" evidence="12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000767320.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401774.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K72"/>
    <dbReference type="STRING" id="300267.SDY_0047"/>
    <dbReference type="EnsemblBacteria" id="ABB60285">
        <property type="protein sequence ID" value="ABB60285"/>
        <property type="gene ID" value="SDY_0047"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0047"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.51"/>
    <dbReference type="HOGENOM" id="CLU_048437_0_1_6"/>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 12" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="13">
        <location>
            <begin position="184"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB60285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="313" mass="34714" checksum="DC60396EDD75DBD2" modified="2005-12-06" version="1">MKLIRGIHNLSQAPQEGCVLTIGNFDGVHRGHRALLQGLQEEGRKRNLPVMVMLFEPQPLELFATDKAPARLTRLREKLRYLAECGVDYVLCVHFDRRFAALTAQNFISDLLVKHLRVKFLAVGDDFRFGAGREGNFLLLQKAGMEYGFDITSTQTFCEGGVRISSTAVRQALADDNLALAESLLGHPFAISGRVVHGDELGRTIGFPTANVPLRRQVSPVKGVYAVEVLGLGEKPLPGVANIGTRPTVAGIRQQLEVHLLDVAMDLYGRHIQVVLRKKIRNEQRFASLDELKAQIARDELTAREFFGLTKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q326R9</accession>
    <name>Q326R9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MxiI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mxiI</name>
        <name evidence="1" type="ordered locus">SDY_P176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001106824.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406177.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326R9"/>
    <dbReference type="EnsemblBacteria" id="ABB64689">
        <property type="protein sequence ID" value="ABB64689"/>
        <property type="gene ID" value="SDY_P176"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P176"/>
    <dbReference type="HOGENOM" id="CLU_2345107_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="97" mass="10752" checksum="F46D83BADA082802" modified="2005-12-06" version="1">MNYIYPVNQVDIIKASDFQSQEISSLEEVVSAKYSDIKMDTDIQVSQIMEMVSNQESLNPESLAKLQMMLSNYSIGISLAGTLARKTVSAVETLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q326S5</accession>
    <name>Q326S5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IcsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">icsB</name>
        <name evidence="1" type="ordered locus">SDY_P170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000601046.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406171.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326S5"/>
    <dbReference type="EnsemblBacteria" id="ABB64683">
        <property type="protein sequence ID" value="ABB64683"/>
        <property type="gene ID" value="SDY_P170"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P170"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5728"/>
    <dbReference type="HOGENOM" id="CLU_613784_0_0_6"/>
    <dbReference type="OMA" id="MSKFICQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011070">
        <property type="entry name" value="Globular_prot_asu/bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56568">
        <property type="entry name" value="SSF56568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="494" mass="56347" checksum="6189E65B763D90FA" modified="2005-12-06" version="1">MILKISNFIDASNTKGPIRVEDTEHGPILVAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLANQKSLLLFLKTLASEKSAESAFAAYEAVKNSIQHSFTGKDIKLMLNTAERFHGIGTAKNLERHLVFRCWENRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISDQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISYNLFGLDETNMSKFICQKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNNVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMSRVLNELKTGATDKKEEIIEKSIKTIDYYNSLKSPDLGTKLYIHDLLQVNKLLLNNSHSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q326X9</accession>
    <name>Q326X9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406117.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326X9"/>
    <dbReference type="EnsemblBacteria" id="ABB64629">
        <property type="protein sequence ID" value="ABB64629"/>
        <property type="gene ID" value="SDY_P116"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P116"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5671"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11184" checksum="3F1F7770DE4B3701" modified="2005-12-06" version="1">MSRKTQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGTLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDISKKTTAYFAQESLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q327F7</accession>
    <name>Q327F7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ipaH7.8</name>
        <name evidence="13" type="ordered locus">SDY_P038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="13 14">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Sd197</strain>
            <plasmid evidence="14">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LRR-containing bacterial E3 ligase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011379043.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406039.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327F7"/>
    <dbReference type="EnsemblBacteria" id="ABB64551">
        <property type="protein sequence ID" value="ABB64551"/>
        <property type="gene ID" value="SDY_P038"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P038"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5580"/>
    <dbReference type="HOGENOM" id="CLU_018533_2_0_6"/>
    <dbReference type="OMA" id="LTSNEHY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032674">
        <property type="entry name" value="LRR_E3_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029487">
        <property type="entry name" value="NEL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14496">
        <property type="entry name" value="NEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12468">
        <property type="entry name" value="TTSSLRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0614">Plasmid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="TTSSLRR" evidence="11">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="NEL" evidence="12">
        <location>
            <begin position="281"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB64551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="565" mass="64512" checksum="5F2A519647E0C080" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q327G3</accession>
    <name>Q327G3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">parB</name>
        <name evidence="3" type="ordered locus">SDY_P032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000431558.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406033.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327G3"/>
    <dbReference type="EnsemblBacteria" id="ABB64545">
        <property type="protein sequence ID" value="ABB64545"/>
        <property type="gene ID" value="SDY_P032"/>
    </dbReference>
    <dbReference type="GeneID" id="58462606"/>
    <dbReference type="KEGG" id="sdy:SDY_P032"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5571"/>
    <dbReference type="HOGENOM" id="CLU_065144_0_0_6"/>
    <dbReference type="OMA" id="REIGQQC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014884">
        <property type="entry name" value="ParB_fam_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08775">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="52"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="326" mass="36855" checksum="10DEF29E73E7AD69" modified="2005-12-06" version="1">MENRKHRPTIGRTLNTNILNNTEEISAPVHVFTLNTGRKAKFTEIKVDHDKVDTQTFVVEEVNGREQTALTPDSLKDITRTIRLQQFYPCIGIRTGDLIEILDGSRRRAAALLCKVGLRVLVTDDELTVSEAQHLAKDLQTSLEHNIREIGLRLVRLKEAGMNQKQIAEREGLSAAKVTRALQAASVPKDFVSLFPVQSELTYADYRQLAELSERLRLGDISIDEVVKNISPSIELITADDNLSEDEVKNSIMRLITKEMSSLLDSGVKDKAVVTLLWKFDSKDKFARKRVKGRTFSYEFGRLPLEVQDKLDRMIALVLKDNLNSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q327N4</accession>
    <name>DNAT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Primosomal protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Primosomal protein I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaT</name>
        <name type="ordered locus">SDY_4616</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378979.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405962.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327N4"/>
    <dbReference type="SMR" id="Q327N4"/>
    <dbReference type="STRING" id="300267.SDY_4616"/>
    <dbReference type="EnsemblBacteria" id="ABB64471">
        <property type="protein sequence ID" value="ABB64471"/>
        <property type="gene ID" value="SDY_4616"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4616"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5471"/>
    <dbReference type="HOGENOM" id="CLU_1501592_0_0_6"/>
    <dbReference type="OMA" id="ASFVAYW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01061">
        <property type="entry name" value="DnaT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020917">
        <property type="entry name" value="DnaT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040480">
        <property type="entry name" value="DnaT_DNA_bind"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17948">
        <property type="entry name" value="DnaT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0639">Primosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000228962" description="Primosomal protein 1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="179" mass="19469" checksum="E68DFFBFC3F6370A" modified="2005-12-06" version="1">MSSRVLTPDVVGIDALVHDHQTVLAKAEGGVVAVFANNAPAFYAVTPARLAELLALEEKLARPGSDVALDEQLYQEPQAAPVAVPMGKFAMYPDWQPDADFIRLAALWGVALREPVTTEELASFIAYWQAEGKVFHHVQWQQKLARSLQIGRASNGGLPKRDVNTVSEPDSQIPPGFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q327S0</accession>
    <name>Q327S0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4307</name>
        <name evidence="3" type="ordered locus">SDY_4571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64203">
        <property type="protein sequence ID" value="ABB64203"/>
        <property type="gene ID" value="SDY_4307"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64435">
        <property type="protein sequence ID" value="ABB64435"/>
        <property type="gene ID" value="SDY_4571"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4307"/>
    <dbReference type="KEGG" id="sdy:SDY_4571"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="CAGWVPH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="31931" checksum="BA8A5B7956555123" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLGVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q328K7</accession>
    <name>Q328K7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjfP</name>
        <name evidence="2" type="ordered locus">SDY_4359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000569685.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405739.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328K7"/>
    <dbReference type="STRING" id="300267.SDY_4359"/>
    <dbReference type="ESTHER" id="shifl-YJFP">
        <property type="family name" value="5_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.A46"/>
    <dbReference type="EnsemblBacteria" id="ABB64248">
        <property type="protein sequence ID" value="ABB64248"/>
        <property type="gene ID" value="SDY_4359"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4359"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5147"/>
    <dbReference type="HOGENOM" id="CLU_094948_1_0_6"/>
    <dbReference type="OMA" id="PLFIWHG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="86"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="249" mass="27520" checksum="F46A79183F41FBEA" modified="2005-12-06" version="1">MIEIESRELADIPVLHAYPVGQKDTPLPCAIFYHGFTSSSLVYSYFAVALAQAGLRVIMPDAPDHGSRFSGDAARRLNQFWQILLQSMQEFTTLRAAIAEENWLLDDRLAVGGASMGAMTALGITARHPTVKCTASMMGSGYFTSLARSLFPPLIPETAAQQNEFNNIVAPLAEWEATNHMEQLGDRPLLLWHGLDDDVVPADESLRLQQALSETGRDKLLTCSWQPGVRHRITPEALDAAVTFFRQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Q3</accession>
    <name>Q328Q3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001221634.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405693.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Q3"/>
    <dbReference type="EnsemblBacteria" id="ABB64202">
        <property type="protein sequence ID" value="ABB64202"/>
        <property type="gene ID" value="SDY_4306"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4306"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5081"/>
    <dbReference type="HOGENOM" id="CLU_130328_0_0_6"/>
    <dbReference type="OMA" id="KCYLANN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021696">
        <property type="entry name" value="DUF3279"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11682">
        <property type="entry name" value="zinc_ribbon_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="144" mass="16555" checksum="60799848292FA2E9" modified="2005-12-06" version="1">MRILNCYMTNDSKGHFVTAKEAAKHNRQDVLCCVSCGCPLTLQRGNDGQPPWFEHDQMTVAEKILLRCTWLDPAEKEARRLHLQGMTVPDYTVKVRKWFCVMCDEDYEGEKCCPRCGTGVYSRAWGRQEVPSEDARADNPLQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q329I9</accession>
    <name>Q329I9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjcZ</name>
        <name evidence="1" type="ordered locus">SDY_4103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405507.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329I9"/>
    <dbReference type="STRING" id="300267.SDY_4103"/>
    <dbReference type="EnsemblBacteria" id="ABB64016">
        <property type="protein sequence ID" value="ABB64016"/>
        <property type="gene ID" value="SDY_4103"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4103"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4826"/>
    <dbReference type="HOGENOM" id="CLU_081244_0_0_6"/>
    <dbReference type="OMA" id="MLESVYP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025599">
        <property type="entry name" value="YjcZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13990">
        <property type="entry name" value="YjcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="281" mass="31716" checksum="1AC5A2CADF6C1E30" modified="2005-12-06" version="1">MLESVHPRFLVDLAQGDDARLPQAHQQQFRERLMQELLARVQLQTGTNDGMLNAPLSLRLTLVEKLASMLDPGHLALTQIAQHLALLQKMDHRQHSAFPELPQQIAALYEWFSARCRWKEKALTQRGLLVQAGEQSEQIFTRWRAGAYNAWSLPGRCFIVLEELRWGAFGDACRLGSPQAVALLLGDLRVKATQHLAESINAAPTTRHYYHQWFASSTVPTGGDHADFLSWLGKWTTADKQPVCWSVTQRWQTVALGMPRLCSAQRLVGAMLEEIFSVNLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q329R2</accession>
    <name>PSTB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphate import ATP-binding protein PstB</fullName>
            <ecNumber evidence="2">7.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ABC phosphate transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphate-transporting ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pstB</name>
        <name type="ordered locus">SDY_4025</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:24440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.3.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.</text>
    </comment>
    <dbReference type="EC" id="7.3.2.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000063125.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405434.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329R2"/>
    <dbReference type="SMR" id="Q329R2"/>
    <dbReference type="STRING" id="300267.SDY_4025"/>
    <dbReference type="EnsemblBacteria" id="ABB63943">
        <property type="protein sequence ID" value="ABB63943"/>
        <property type="gene ID" value="SDY_4025"/>
    </dbReference>
    <dbReference type="GeneID" id="66672375"/>
    <dbReference type="KEGG" id="sdy:SDY_4025"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4739"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="TIDICRV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51238">
        <property type="entry name" value="PSTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0592">Phosphate transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000272528" description="Phosphate import ATP-binding protein PstB">
        <location>
            <begin position="2"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01702"/>
        </source>
    </evidence>
    <sequence length="257" mass="29027" checksum="15A09F9DC3EB013A" modified="2005-12-06" version="1">MSMVETAPSKIQVRNLNFYYGKFHALKNINLDIAKNQVTAFIGPSGCGKSTLLRTFNKMFELYPEQRAEGEILLDGDNILTNSQDIALLRAKVGMVFQKPTPFPMSIYDNIAFGVRLFEKLSRADMDERVQWALTKAALWNETKDKLHQSGYSLSGGQQQRLCIARGIAIRPEVLLLDEPCSALDPISTGRIEELITELKQDYTVVIVTHNMQQAARCSDHTAFMYLGELIEFSNTDDLFTKPAKKQTEDYITGRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q329W6</accession>
    <name>Q329W6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosamine dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.336</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">UDP-ManNAc 6-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">wecC</name>
        <name evidence="5" type="ordered locus">SDY_3961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate</text>
            <dbReference type="Rhea" id="RHEA:25780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:70731"/>
            <dbReference type="EC" id="1.1.1.336"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000006638.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405380.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329W6"/>
    <dbReference type="STRING" id="300267.SDY_3961"/>
    <dbReference type="EnsemblBacteria" id="ABB63889">
        <property type="protein sequence ID" value="ABB63889"/>
        <property type="gene ID" value="SDY_3961"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3961"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4673"/>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_6"/>
    <dbReference type="OMA" id="IELANTH"/>
    <dbReference type="UniPathway" id="UPA00566"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009246">
        <property type="term" value="P:enterobacterial common antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02029">
        <property type="entry name" value="WecC_RffD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032891">
        <property type="entry name" value="WecC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="324"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with dimeric partner" evidence="3">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="330"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="420" mass="45865" checksum="65A89A51F3A7DD11" modified="2005-12-06" version="1">MSFATISVIGLGYIGLPTAAAFASRQKQVIGVDINQYAVDTINRGEIHIVEPDLASVVKTAVEGGFLRASTTPVEADAWLIAVPTPFKGDHEPDMTYVESAARSIAPVLKKGALVILESTSPVGSTEKMAEWLAEMRPDLTFPQQVGEQADVNIAYCPERVLPGQVMVELIKNDRVIGGMTPVCSARASELYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINVWELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDHKPFWVIDQVKAAVADCLAATDKRASELKIACFGLAFKPNIDDLRESPAMEIAELIAQWHSGETLVVEPNIHQLPKKLTGLCTLAQLDEALATADVLVMLVDHSQFKVINGDNVHQQYVVDAKGVWR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Y2</accession>
    <name>CYAY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Iron-sulfur cluster assembly protein CyaY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cyaY</name>
        <name type="ordered locus">SDY_3938</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000999947.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405364.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Y2"/>
    <dbReference type="SMR" id="Q329Y2"/>
    <dbReference type="STRING" id="300267.SDY_3938"/>
    <dbReference type="EnsemblBacteria" id="ABB63872">
        <property type="protein sequence ID" value="ABB63872"/>
        <property type="gene ID" value="SDY_3938"/>
    </dbReference>
    <dbReference type="GeneID" id="66672289"/>
    <dbReference type="KEGG" id="sdy:SDY_3938"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4650"/>
    <dbReference type="HOGENOM" id="CLU_080880_3_0_6"/>
    <dbReference type="OMA" id="EPMHEIW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00142">
        <property type="entry name" value="CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="PTHR16821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="SSF55387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000010961" description="Iron-sulfur cluster assembly protein CyaY">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00142"/>
        </source>
    </evidence>
    <sequence length="106" mass="12231" checksum="03EA6F330A48F711" modified="2005-12-06" version="1">MNDSEFHRLADQLWLTIEERLDDWDGDSDIDCEINGGVLTITFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWICDRSGETFWDLLEQAATQQAGETVSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A29</accession>
    <name>Q32A29_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress response kinase A</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Serine/threonine-protein kinase SrkA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yihE</name>
        <name evidence="2" type="synonym">srkA</name>
        <name evidence="4" type="ordered locus">SDY_3886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SrkA/RdoA protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001065515.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405317.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A29"/>
    <dbReference type="STRING" id="300267.SDY_3886"/>
    <dbReference type="EnsemblBacteria" id="ABB63826">
        <property type="protein sequence ID" value="ABB63826"/>
        <property type="gene ID" value="SDY_3886"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3886"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4599"/>
    <dbReference type="HOGENOM" id="CLU_054715_0_0_6"/>
    <dbReference type="OMA" id="MHYSAWL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01497">
        <property type="entry name" value="SrkA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032882">
        <property type="entry name" value="SrkA/RdoA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39573">
        <property type="entry name" value="PTHR39573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1 2" id="KW-0346">Stress response</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="3">
        <location>
            <begin position="32"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="ATP" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="328" mass="38111" checksum="4693AB47B73E5B03" modified="2005-12-06" version="1">MNNSAFTFQTLHPDTIMDALFEQGIRVDSGLTPLNSYENRVYQFQDEDRRRFVVKFYRPERWTADQILEEHQFALQLVNDEVPVAAPVAFNGQTLLNHQGFYFAVFPSVGGRQFEADNIDQMEAVGRYLGRMHQTGRKQLFIHRPTIGLNEYLIEPRKLFEDATLIPSGLKAAFLKATDELIAAVTAHWREDFTVLRLHGDCHAGNILWRDGPMFVDLDDARNGPAIQDLWMLLNGDKAEQRMQLETIIEAYEEFSEFDTAEIGLIEPLRAMRLVYYLAWLMRRWADPAFPKNFPWLTGEDYWLRQTATFIEQAKVLQDPPLQLTPMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A47</accession>
    <name>Q32A47_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0239</name>
        <name evidence="4" type="ordered locus">SDY_3866</name>
        <name evidence="5" type="ordered locus">SDY_4214</name>
        <name evidence="6" type="ordered locus">SDY_4516</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60463">
        <property type="protein sequence ID" value="ABB60463"/>
        <property type="gene ID" value="SDY_0239"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63808">
        <property type="protein sequence ID" value="ABB63808"/>
        <property type="gene ID" value="SDY_3866"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64118">
        <property type="protein sequence ID" value="ABB64118"/>
        <property type="gene ID" value="SDY_4214"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64390">
        <property type="protein sequence ID" value="ABB64390"/>
        <property type="gene ID" value="SDY_4516"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0239"/>
    <dbReference type="KEGG" id="sdy:SDY_3866"/>
    <dbReference type="KEGG" id="sdy:SDY_4214"/>
    <dbReference type="KEGG" id="sdy:SDY_4516"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8512" checksum="43F98C8D54135D06" modified="2005-12-06" version="1">MITSDDWASYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A73</accession>
    <name>Q32A73_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Superoxide dismutase</fullName>
            <ecNumber evidence="5 9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sodA</name>
        <name evidence="12" type="ordered locus">SDY_3838</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="5 9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005015733.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405273.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A73"/>
    <dbReference type="STRING" id="300267.SDY_3838"/>
    <dbReference type="EnsemblBacteria" id="ABB63782">
        <property type="protein sequence ID" value="ABB63782"/>
        <property type="gene ID" value="SDY_3838"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3838"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4533"/>
    <dbReference type="HOGENOM" id="CLU_031625_0_1_6"/>
    <dbReference type="OMA" id="YEGWKGE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="11">
        <location>
            <begin position="96"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="206" mass="23093" checksum="49E79EC88F3C1417" modified="2005-12-06" version="1">MSYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLEQLPADKKTVLRNNAGGHANHSLFWKGLKKGTTLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGDKLAVVSTANQDSPLMGEAISGASGFPILGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAARFAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AK0</accession>
    <name>Q32AK0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein DamX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">damX</name>
        <name evidence="4" type="ordered locus">SDY_3691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Non-essential cell division protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes at the septal ring.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SPOR domain binds septal peptidoglycans and is required to target DamX to the septal ring.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DamX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000343165.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405146.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AK0"/>
    <dbReference type="STRING" id="300267.SDY_3691"/>
    <dbReference type="EnsemblBacteria" id="ABB63655">
        <property type="protein sequence ID" value="ABB63655"/>
        <property type="gene ID" value="SDY_3691"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3691"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4379"/>
    <dbReference type="HOGENOM" id="CLU_048276_1_0_6"/>
    <dbReference type="OMA" id="ASRQYIM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02021">
        <property type="entry name" value="DamX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032899">
        <property type="entry name" value="DamX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="339"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="425" mass="45760" checksum="5D8D635A9B9D80B4" modified="2005-12-06" version="1">MDEFKPEDELKPDPSDRRTGRSRQSSERSERGEPQINFDDIELDDTDDRRPTRAQKERNEEPEIEEEIDESEDETVDEERVERRPRKRKKAASKPASRQYMMMGVGILVLLLLIIGIGSALKAPSTTSSDQTASGEKSIDLAGNATDQANGVQPAPGTTSAENTQQDVSLPPISSTPTQGQTPVATDGQQRVEVQGDLNNALTQPQNQQQLNNVAVNSTLPTEPATVAPVRNGNASRDTAKTQTAERPATTRPARQQAVIEPKKPQATVKTEPKPVAQTPKRTEPAAPVASTKAPAATSTPAPKETATTAPVQTASPAQTTATPAAGGKTAGNVGSLKSAPSSHYTLQLSSSSNYDNLNGWAKKENLKNYVVYETTRNGQPWYVLVSGVYASKEEAKKAVSTLPADVQAKNPWAKPLRQIQADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AP4</accession>
    <name>Q32AP4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_3643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405102.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AP4"/>
    <dbReference type="STRING" id="300267.SDY_3643"/>
    <dbReference type="EnsemblBacteria" id="ABB63611">
        <property type="protein sequence ID" value="ABB63611"/>
        <property type="gene ID" value="SDY_3643"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3643"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4325"/>
    <dbReference type="HOGENOM" id="CLU_040393_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015577">
        <property type="term" value="F:galactitol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013853">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004703">
        <property type="entry name" value="PTS_sugar-sp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37324">
        <property type="entry name" value="PTHR37324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03611">
        <property type="entry name" value="EIIC-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="127" mass="13651" checksum="FA1A0D6C0B35B9F1" modified="2005-12-06" version="1">MNDIAHTLYNIVQYILGFGPTVMLPLVLFILALCFKVKPAKALRSSLTVGIGFVGIYAIFDILTSNVGPAAQAMVERTGINLPVVDLGWPPLSAITWGSPIAPFVIPLTILINVAVMLPISRTCVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AP7</accession>
    <name>Q32AP7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AP7"/>
    <dbReference type="STRING" id="300267.SDY_3640"/>
    <dbReference type="EnsemblBacteria" id="ABB63608">
        <property type="protein sequence ID" value="ABB63608"/>
        <property type="gene ID" value="SDY_3640"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3640"/>
    <dbReference type="HOGENOM" id="CLU_2620100_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="78" mass="8995" checksum="A3143F5C41D5783A" modified="2005-12-06" version="1">MAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITVFFSRGLPIEFGNVWLKGNKYYLGTVLQRREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AR5</accession>
    <name>Q32AR5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">zntA</name>
        <name evidence="10" type="ordered locus">SDY_3620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000106586.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405081.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AR5"/>
    <dbReference type="STRING" id="300267.SDY_3620"/>
    <dbReference type="EnsemblBacteria" id="ABB63590">
        <property type="protein sequence ID" value="ABB63590"/>
        <property type="gene ID" value="SDY_3620"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3620"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4296"/>
    <dbReference type="HOGENOM" id="CLU_001771_6_4_6"/>
    <dbReference type="OMA" id="FAQPWET"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="49"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="732" mass="76896" checksum="842BF70C33372740" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AX8</accession>
    <name>Q32AX8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405018.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AX8"/>
    <dbReference type="EnsemblBacteria" id="ABB63527">
        <property type="protein sequence ID" value="ABB63527"/>
        <property type="gene ID" value="SDY_3553"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3553"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4216"/>
    <dbReference type="HOGENOM" id="CLU_2381556_0_0_6"/>
    <dbReference type="OMA" id="IDNNSHY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="98" mass="11981" checksum="46BB188567DFFB5C" modified="2005-12-06" version="1">MIFIKIFRQLTFLLPTKFHRWKKLRTQRYRGLQSKEKKKLSLLTTKFSDEAWGDNHKNKVVYRAQDRFHNPLFIVLMVVKKLDHKKLIDNNSHYHICI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B11</accession>
    <name>YHEU_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0270 protein YheU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yheU</name>
        <name type="ordered locus">SDY_3516</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0270 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000909421.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404985.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B11"/>
    <dbReference type="SMR" id="Q32B11"/>
    <dbReference type="STRING" id="300267.SDY_3516"/>
    <dbReference type="EnsemblBacteria" id="ABB63494">
        <property type="protein sequence ID" value="ABB63494"/>
        <property type="gene ID" value="SDY_3516"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3516"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4170"/>
    <dbReference type="HOGENOM" id="CLU_186759_1_0_6"/>
    <dbReference type="OMA" id="MIIPWKE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00690">
        <property type="entry name" value="UPF0270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010648">
        <property type="entry name" value="UPF0270"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036685">
        <property type="entry name" value="YehU-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06794">
        <property type="entry name" value="UPF0270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006169">
        <property type="entry name" value="UCP006169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118001">
        <property type="entry name" value="SSF118001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000045175" description="UPF0270 protein YheU">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00690"/>
        </source>
    </evidence>
    <sequence length="72" mass="8474" checksum="54001FCE936F4215" modified="2005-12-06" version="1">MLITWQDLSPETLENLIESFVLREGTDYGEHERTLEQKVADVKRQLQCGEAVLVWSELHETVNIMPRSQFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B16</accession>
    <name>Q32B16_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001007730.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404980.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B16"/>
    <dbReference type="STRING" id="300267.SDY_3511"/>
    <dbReference type="EnsemblBacteria" id="ABB63489">
        <property type="protein sequence ID" value="ABB63489"/>
        <property type="gene ID" value="SDY_3511"/>
    </dbReference>
    <dbReference type="GeneID" id="67416981"/>
    <dbReference type="KEGG" id="sdy:SDY_3511"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4165"/>
    <dbReference type="HOGENOM" id="CLU_186875_0_0_6"/>
    <dbReference type="OMA" id="DTLRWWI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012658">
        <property type="entry name" value="CHP02443"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09526">
        <property type="entry name" value="DUF2387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02443">
        <property type="entry name" value="TIGR02443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7599" checksum="D6AFBF8257D84645" modified="2005-12-06" version="1">MAIRKRFIAGAKCPACQAQDSMAMWRENNIDIVECVKCGHQMREADKEARDHVRKDEQVIGIFHPD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B45</accession>
    <name>RS8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsH</name>
        <name type="ordered locus">SDY_3482</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000062611.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404951.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B45"/>
    <dbReference type="SMR" id="Q32B45"/>
    <dbReference type="STRING" id="300267.SDY_3482"/>
    <dbReference type="EnsemblBacteria" id="ABB63460">
        <property type="protein sequence ID" value="ABB63460"/>
        <property type="gene ID" value="SDY_3482"/>
    </dbReference>
    <dbReference type="GeneID" id="67415347"/>
    <dbReference type="KEGG" id="sdy:SDY_3482"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4135"/>
    <dbReference type="HOGENOM" id="CLU_098428_0_0_6"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000225892" description="30S ribosomal protein S8">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <sequence length="130" mass="14127" checksum="74641BC5021DA651" modified="2005-12-06" version="1">MSMQDPIADMLTRIRNGQAANKAAVTMPSSKLKVAIANVLKEEGFIEDFKVEGDTKPELELTLKYFQGKAVVESIQRVSRPGLRIYKRKDELPKVMAGLGIAVVSTSKGVMTDRAARQAGLGGEIICYVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B52</accession>
    <name>RL36_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmJ</name>
        <name type="ordered locus">SDY_3475</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000868187.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404944.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B52"/>
    <dbReference type="SMR" id="Q32B52"/>
    <dbReference type="STRING" id="300267.SDY_3475"/>
    <dbReference type="EnsemblBacteria" id="ABB63453">
        <property type="protein sequence ID" value="ABB63453"/>
        <property type="gene ID" value="SDY_3475"/>
    </dbReference>
    <dbReference type="GeneID" id="64727524"/>
    <dbReference type="GeneID" id="67515060"/>
    <dbReference type="KEGG" id="sdy:SDY_3475"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4128"/>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_6"/>
    <dbReference type="PRO" id="PR:Q32B52"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000302297" description="50S ribosomal protein L36">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <sequence length="38" mass="4364" checksum="C4785CEC0578EB24" modified="2005-12-06" version="1">MKVRASVKKLCRNCKIVKRDGVIRVICSAEPKHKQRQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B53</accession>
    <name>RS13_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsM</name>
        <name type="ordered locus">SDY_3474</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000090775.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404943.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B53"/>
    <dbReference type="SMR" id="Q32B53"/>
    <dbReference type="STRING" id="300267.SDY_3474"/>
    <dbReference type="EnsemblBacteria" id="ABB63452">
        <property type="protein sequence ID" value="ABB63452"/>
        <property type="gene ID" value="SDY_3474"/>
    </dbReference>
    <dbReference type="GeneID" id="67415339"/>
    <dbReference type="KEGG" id="sdy:SDY_3474"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4127"/>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_6"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000230564" description="30S ribosomal protein S13">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="118" mass="13099" checksum="6277C365EBE4F732" modified="2005-12-06" version="1">MARIAGINIPDHKHAVIALTSIYGVGKTRSKAILAAAGIAEDVKISELSEGQIDTLRDEVAKFVVEGDLRREISMSIKRLMDLGCYRGLRHRRGLPVRGQRTKTNARTRKGPRKPIKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B61</accession>
    <name>RSMB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase B</fullName>
            <ecNumber evidence="1">2.1.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m5C967 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-C(5)-)-methyltransferase RsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmB</name>
        <name evidence="1" type="synonym">sun</name>
        <name type="ordered locus">SDY_3465</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42748"/>
            <dbReference type="Rhea" id="RHEA-COMP:10219"/>
            <dbReference type="Rhea" id="RHEA-COMP:10220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.176"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018921.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404935.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B61"/>
    <dbReference type="SMR" id="Q32B61"/>
    <dbReference type="STRING" id="300267.SDY_3465"/>
    <dbReference type="EnsemblBacteria" id="ABB63444">
        <property type="protein sequence ID" value="ABB63444"/>
        <property type="gene ID" value="SDY_3465"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3465"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4118"/>
    <dbReference type="HOGENOM" id="CLU_005316_0_4_6"/>
    <dbReference type="OMA" id="RVNRQHH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016434">
        <property type="term" value="F:rRNA (cytosine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01856">
        <property type="entry name" value="16SrRNA_methyltr_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023541">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B_ent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000366178" description="Ribosomal RNA small subunit methyltransferase B">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="254"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01856"/>
        </source>
    </evidence>
    <sequence length="429" mass="48349" checksum="9B84CC085A4F972A" modified="2005-12-06" version="1">MKKQRNLRSMAAQAVEQVVEQGQSLSNILPPLQQKVSDKDKALLQELCFGVLRTLSQLDWLINKLMARPMSGKQRTVHYLIMVGLYQLLYTRIPPHAALAETVEGAIAIKRPQLKGLINGVLRQFQRQQEELLAEFNTSDARYLHPSWLLKRLQKAYPEQWQSIVEANNQRPPMWLRINRTHHSRDSWLALLDEAGMKGFPHADYPDAVRLETPAPVHALPGFEDGWVTVQDASAQGCMTWLAPQNGKHILDLCAAPGGKTTHILEVAPEAQVVAVDIDEQRLSRVYDNLKRLGMKATVKQGDGRYPSQWCGEQQFDRILLDAPCSATGVIRRHPDIKWLRRDRDIPELAQLQSEILDAIWPHLKSGGTLVYATCSVLPEENSLQIKAFLQRTADAELCETGTPEQPGKQNLPGAEEGDGFFYAKLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BB8</accession>
    <name>Q32BB8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yhcH</name>
        <name evidence="1" type="ordered locus">SDY_3396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000979896.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404878.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BB8"/>
    <dbReference type="STRING" id="300267.SDY_3396"/>
    <dbReference type="EnsemblBacteria" id="ABB63387">
        <property type="protein sequence ID" value="ABB63387"/>
        <property type="gene ID" value="SDY_3396"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3396"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4052"/>
    <dbReference type="HOGENOM" id="CLU_107139_3_1_6"/>
    <dbReference type="OMA" id="FIDIQIP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004375">
        <property type="entry name" value="NanQ/TabA/YiaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037012">
        <property type="entry name" value="NanQ/TabA/YiaL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34986">
        <property type="entry name" value="PTHR34986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04074">
        <property type="entry name" value="DUF386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00022">
        <property type="entry name" value="TIGR00022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="154" mass="17065" checksum="2945651ED1AD5200" modified="2005-12-06" version="1">MMMGEVQSLPSAGLHPVLQDALTLALAARPQEKAPGRYELQGDNIFMNVMTFNTQSPVEKKAELHEQYIDIQLLLKGEERILFGTAGTARQCEEFHHEDDYQLCSAIENEQTINLKPGMFAVFMPGEPHKPGCVVGEPGEIKKVVVKVKADLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BF5</accession>
    <name>Q32BF5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hflB</name>
        <name evidence="5" type="synonym">ftsH</name>
        <name evidence="9" type="ordered locus">SDY_3359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001107460.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404841.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BF5"/>
    <dbReference type="STRING" id="300267.SDY_3359"/>
    <dbReference type="MEROPS" id="M41.001"/>
    <dbReference type="EnsemblBacteria" id="ABB63350">
        <property type="protein sequence ID" value="ABB63350"/>
        <property type="gene ID" value="SDY_3359"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3359"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4013"/>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_6"/>
    <dbReference type="OMA" id="QYGMTER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="184"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="644" mass="70722" checksum="EFE431AD8A405E9B" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BH1</accession>
    <name>Q32BH1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase DeaD</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cold-shock DEAD box protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 13" type="primary">deaD</name>
        <name evidence="6" type="synonym">csdA</name>
        <name evidence="13" type="ordered locus">SDY_3341</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BH1"/>
    <dbReference type="STRING" id="300267.SDY_3341"/>
    <dbReference type="EnsemblBacteria" id="ABB63334">
        <property type="protein sequence ID" value="ABB63334"/>
        <property type="gene ID" value="SDY_3341"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3341"/>
    <dbReference type="HOGENOM" id="CLU_003041_21_1_6"/>
    <dbReference type="OMA" id="LPQGMPK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070417">
        <property type="term" value="P:cellular response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12499">
        <property type="entry name" value="RRM_EcCsdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00964">
        <property type="entry name" value="DEAD_helicase_DeaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021046">
        <property type="entry name" value="Cold-shock_DEAD_Abox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034415">
        <property type="entry name" value="CsdA_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028618">
        <property type="entry name" value="DEAD_helicase_DeaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12343">
        <property type="entry name" value="DeaD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="12">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="54"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="249"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="577"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="646" mass="72798" checksum="3EFD1C97D53C9450" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BH6</accession>
    <name>Q32BH6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone biosynthesis accessory factor UbiT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhbT</name>
        <name evidence="1" type="synonym">ubiT</name>
        <name evidence="3" type="ordered locus">SDY_3336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295552.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404820.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BH6"/>
    <dbReference type="SMR" id="Q32BH6"/>
    <dbReference type="STRING" id="300267.SDY_3336"/>
    <dbReference type="EnsemblBacteria" id="ABB63329">
        <property type="protein sequence ID" value="ABB63329"/>
        <property type="gene ID" value="SDY_3336"/>
    </dbReference>
    <dbReference type="GeneID" id="66672942"/>
    <dbReference type="KEGG" id="sdy:SDY_3336"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3990"/>
    <dbReference type="HOGENOM" id="CLU_111894_1_0_6"/>
    <dbReference type="OMA" id="RDIGLRW"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02231">
        <property type="entry name" value="UbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039543">
        <property type="entry name" value="POX18/UbiT/NSL-TP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016830">
        <property type="entry name" value="UbiT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="PTHR10094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025550">
        <property type="entry name" value="UCP025550_lpd_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="SCP2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="174" mass="19672" checksum="64AF738130508204" modified="2005-12-06" version="1">MLDKLRSRIVHLGPSLLSVPVKLTPFALKRQVLEQVLSWQFRQALDDGELEFLEGRWLSIHVRDIDLQWFTSVVNGKLVVSQNAQADVSFSADASDLLMIAARKQDPDTLFFQRRLVIEGDTELGLYVKNLMDAIELEQMPKALRMMLLQLADFVEAGMKTAPETKQTSVGEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BM4</accession>
    <name>Q32BM4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Modulator protein MzrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yqjB</name>
        <name evidence="2" type="synonym">mzrA</name>
        <name evidence="4" type="ordered locus">SDY_3283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with EnvZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MzrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001166761.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404772.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BM4"/>
    <dbReference type="STRING" id="300267.SDY_3283"/>
    <dbReference type="EnsemblBacteria" id="ABB63281">
        <property type="protein sequence ID" value="ABB63281"/>
        <property type="gene ID" value="SDY_3283"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3283"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3925"/>
    <dbReference type="HOGENOM" id="CLU_153761_0_0_6"/>
    <dbReference type="OMA" id="WHHLDAN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045859">
        <property type="term" value="P:regulation of protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00904">
        <property type="entry name" value="Modulator_MzrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026574">
        <property type="entry name" value="Modulator_MzrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027398">
        <property type="entry name" value="SecD-TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13721">
        <property type="entry name" value="SecD-TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SecD-TM1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="127" mass="14163" checksum="814A6F436DFFF786" modified="2005-12-06" version="1">MQIPRMSLRQLAWSGAVLLLVGTLLLAWSAVRQQESTLAIRAVHQGTTMPDGFSIWHHLDAHGIPFKSITPKNDTLLITFDSSDQSAAAKAVLDRTLPQGYIIAQQDNNSQAMQWLTRLRDNSHRFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C31</accession>
    <name>FETP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable Fe(2+)-trafficking protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yggX</name>
        <name type="ordered locus">SDY_3110</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fe(2+)-trafficking protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000091700.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404615.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C31"/>
    <dbReference type="SMR" id="Q32C31"/>
    <dbReference type="STRING" id="300267.SDY_3110"/>
    <dbReference type="EnsemblBacteria" id="ABB63124">
        <property type="protein sequence ID" value="ABB63124"/>
        <property type="gene ID" value="SDY_3110"/>
    </dbReference>
    <dbReference type="GeneID" id="67415146"/>
    <dbReference type="KEGG" id="sdy:SDY_3110"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3719"/>
    <dbReference type="HOGENOM" id="CLU_170994_0_0_6"/>
    <dbReference type="OMA" id="SKQTMLI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3880.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00686">
        <property type="entry name" value="Fe_traffic_YggX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007457">
        <property type="entry name" value="Fe_traffick_prot_YggX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036766">
        <property type="entry name" value="Fe_traffick_prot_YggX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36965">
        <property type="entry name" value="PTHR36965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04362">
        <property type="entry name" value="Iron_traffic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029827">
        <property type="entry name" value="Fe_traffic_YggX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111148">
        <property type="entry name" value="SSF111148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000246117" description="Probable Fe(2+)-trafficking protein">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00686"/>
        </source>
    </evidence>
    <sequence length="91" mass="10953" checksum="1E3625B77C32B94B" modified="2005-12-06" version="1">MSRTIFCTFLQREAEGQDFQLYPGELGKRIYNEISKEAWAQWQHKQTMLINEKKLNMMNAEHRKLLEQEMVNFLFEGKEVHIEGYTPEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C45</accession>
    <name>Q32C45_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Type II secretion system protein E</fullName>
            <shortName evidence="5">T2SS protein E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Type II traffic warden ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gspE</name>
        <name evidence="7" type="ordered locus">SDY_3094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000249362.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404601.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C45"/>
    <dbReference type="STRING" id="300267.SDY_3094"/>
    <dbReference type="EnsemblBacteria" id="ABB63110">
        <property type="protein sequence ID" value="ABB63110"/>
        <property type="gene ID" value="SDY_3094"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3094"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3703"/>
    <dbReference type="HOGENOM" id="CLU_013446_2_0_6"/>
    <dbReference type="OMA" id="LIRKPHG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013369">
        <property type="entry name" value="T2SS_GspE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02533">
        <property type="entry name" value="type_II_gspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T2SP_E" evidence="6">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="497" mass="55159" checksum="D5DA13AF180A8286" modified="2005-12-06" version="1">MVPVAQETTANTVRLPYSFSRRFSLVAWCEASLEILHVHPLSLSVLQELQRGLNAPFTLRQIDEAEFEQRLNTVWQRDSSEARQLMEELGSAEDFFTLAEELPETEDLLESDDDAPIIKLINAMLAEAIKEGASDIHIETFEKSLVIRFRVDGTLHEMLRPGRKLASLLVSRIKVMARLDIAEKRVPQDGRIALLLGGRAIDVRVSTMPSAWGERVVLRLLDKNQASLAQERLGLSQQLTAQLRQLLHKPHGIFLVTGPTGSGKSTTLYAGLQELNNHSRNILTVEDPIEYMIEGIGQTQVNTRVGMTFARGLRAILRQDPDVVMVGEIRDTETAEIAVQASLTGHLVLSTLHTNTAVGTITRLQDMGVEPFLLSSSLTGVMAQRLVRTLCPDCRQAAPATDEETRLLGITDARTVTLYHPQGCPACNHKGFRGRTAIHELIVVDATLRDLIHRQAGEMELERYVRQHSAGIRSNGIEKVLAGETSLDEVLRVTMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CC2</accession>
    <name>Q32CC2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable serine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sdaC</name>
        <name evidence="11" type="ordered locus">SDY_3013</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000450470.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404524.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CC2"/>
    <dbReference type="STRING" id="300267.SDY_3013"/>
    <dbReference type="EnsemblBacteria" id="ABB63033">
        <property type="protein sequence ID" value="ABB63033"/>
        <property type="gene ID" value="SDY_3013"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3013"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3617"/>
    <dbReference type="HOGENOM" id="CLU_052043_1_1_6"/>
    <dbReference type="OMA" id="PLTYLGH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004694">
        <property type="entry name" value="Hydroxy_aa_transpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00814">
        <property type="entry name" value="stp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="429" mass="46846" checksum="3D7B7923996B1366" modified="2005-12-06" version="1">METTQTSTIASKDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGLTRFVLSGKNPGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAITNTVESFMSHQLGMTPPPRAILSLILIVGMMTIVRFGEQMIVKAMSILVFPFVGVLMLLALYLIPQWNGAALETLSLDTASATGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYGDMAEQKCSKILAFAHIMMVLTVMFFVFSCVLGLTPADLAAAKEQNISILSYLANHFNAPVIAWMAPIIAIIAITKSFLGHYLGAREGFNGMVIKSLRGKGKSIEINKLNRITALFMLVTTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAMRKYSGHISNVFVVVMGLIAISAIFYSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CK5</accession>
    <name>Q32CK5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">hypA</name>
        <name evidence="5" type="ordered locus">SDY_2923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378847.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404441.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CK5"/>
    <dbReference type="STRING" id="300267.SDY_2923"/>
    <dbReference type="EnsemblBacteria" id="ABB62950">
        <property type="protein sequence ID" value="ABB62950"/>
        <property type="gene ID" value="SDY_2923"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2923"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3511"/>
    <dbReference type="HOGENOM" id="CLU_126929_0_0_6"/>
    <dbReference type="OMA" id="EEQQAEC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020538">
        <property type="entry name" value="Hydgase_Ni_incorp_HypA/HybF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00100">
        <property type="entry name" value="hypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01249">
        <property type="entry name" value="HYPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="116" mass="13110" checksum="B251D8012C36D912" modified="2005-12-06" version="1">MHEITLCQRALELIAQQAAKHGAKRVTGVWLKIGAFSCVETSSLAFCFDLVCRGSVAEGCKLHLEEQEAECWCETCQQYVTLLTQRVRRCPQCHGDMLQIVADDGLQIRRIEIDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CM2</accession>
    <name>Q32CM2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucitol operon activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gutM</name>
        <name evidence="1" type="ordered locus">SDY_2903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000252895.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404424.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CM2"/>
    <dbReference type="STRING" id="300267.SDY_2903"/>
    <dbReference type="EnsemblBacteria" id="ABB62933">
        <property type="protein sequence ID" value="ABB62933"/>
        <property type="gene ID" value="SDY_2903"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2903"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3488"/>
    <dbReference type="HOGENOM" id="CLU_124480_1_0_6"/>
    <dbReference type="OMA" id="QIALGWW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009693">
        <property type="entry name" value="Glucitol_operon_activator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06923">
        <property type="entry name" value="GutM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011474">
        <property type="entry name" value="Glucitol_operon_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="12925" checksum="87514E45F8199334" modified="2005-12-06" version="1">MVSALITVAAIAWCAQLALGGWQISRFNRAFDTLCQQGRVGVGRSSGRFKPRVVVAIALDDQQRIVDTLFMKGLTVFARPQKIPAITGMHAGDLQPDVIFPHDPLSQNALSLALKLKRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CM9</accession>
    <name>RECA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recA</name>
        <name type="ordered locus">SDY_2895</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000963143.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404417.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CM9"/>
    <dbReference type="SMR" id="Q32CM9"/>
    <dbReference type="STRING" id="300267.SDY_2895"/>
    <dbReference type="EnsemblBacteria" id="ABB62926">
        <property type="protein sequence ID" value="ABB62926"/>
        <property type="gene ID" value="SDY_2895"/>
    </dbReference>
    <dbReference type="GeneID" id="66673432"/>
    <dbReference type="KEGG" id="sdy:SDY_2895"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3478"/>
    <dbReference type="HOGENOM" id="CLU_040469_3_2_6"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_1000048002" description="Protein RecA">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="353" mass="37973" checksum="866EF8F83BE32A36" modified="2005-12-06" version="1">MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPIYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGENVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYKGEKIGQGKANATAWLKDNPETAKEIEKKVRELLLSNPNSTPDFSVDDSEGVAETNEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CX3</accession>
    <name>Q32CX3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recN</name>
        <name evidence="8" type="ordered locus">SDY_2789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000880906.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404323.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CX3"/>
    <dbReference type="STRING" id="300267.SDY_2789"/>
    <dbReference type="EnsemblBacteria" id="ABB62832">
        <property type="protein sequence ID" value="ABB62832"/>
        <property type="gene ID" value="SDY_2789"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2789"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3361"/>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_6"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="326"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="553" mass="61449" checksum="EFD7EAC3819F2043" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CZ0</accession>
    <name>Q32CZ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001181754.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404306.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CZ0"/>
    <dbReference type="STRING" id="300267.SDY_2772"/>
    <dbReference type="EnsemblBacteria" id="ABB62815">
        <property type="protein sequence ID" value="ABB62815"/>
        <property type="gene ID" value="SDY_2772"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2772"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3341"/>
    <dbReference type="HOGENOM" id="CLU_114931_0_0_6"/>
    <dbReference type="OMA" id="MSYVFEF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021283">
        <property type="entry name" value="DUF2612"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11041">
        <property type="entry name" value="DUF2612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="201" mass="22345" checksum="4B6745369D1393E2" modified="2005-12-06" version="1">MQNVAATVLAQYAASPRLNALINSFNAALSPDSFISDFYGLIWNIDTAEKYGLDVWGKIVGVSRRLTVKDDFNYLGFSESRMDTPVMDDPRPFNQAPFYNGKSVTRTADLTDAIYRRLILMKAMSNITDCSVPDINRMLRFMFGKKRRAYVLNNGGLRMSYVFESALSSAELAIIQSSGALPSPPGVYVSVVLKESRNEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D03</accession>
    <name>Q32D03_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phage_tail_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D03"/>
    <dbReference type="EnsemblBacteria" id="ABB62802">
        <property type="protein sequence ID" value="ABB62802"/>
        <property type="gene ID" value="SDY_2759"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2759"/>
    <dbReference type="HOGENOM" id="CLU_014979_4_1_6"/>
    <dbReference type="OMA" id="NAPKMVI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013609">
        <property type="entry name" value="Stf-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08400">
        <property type="entry name" value="phage_tail_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="phage_tail_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="9901" checksum="CCEDD298A62B5F95" modified="2005-12-06" version="1">MSVVISGALTDGAGIPMSGYHIILKSRVNTPEVVMHTVADVMTGNDGEYCFHARTGKYGVYLKQDWRNEYNVGDIAVYEDSKPGTLNDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DG4</accession>
    <name>Q32DG4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000785941.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404132.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DG4"/>
    <dbReference type="STRING" id="300267.SDY_2577"/>
    <dbReference type="EnsemblBacteria" id="ABB62641">
        <property type="protein sequence ID" value="ABB62641"/>
        <property type="gene ID" value="SDY_2577"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2577"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3107"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_5_6"/>
    <dbReference type="OMA" id="YPHMPTG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="412" mass="46264" checksum="EB678D0E1CECC937" modified="2005-12-06" version="1">MADTRPERRFTRIDRLPPYVFNITAELKMAARRRGEDIIDFSMGNPDGATPPHIVEKLCTVAQRPDTHGYSTSRGIPRLRRAISRWYQDRYDVEIDPESEAIVTIGSKEGLAHLMLATLDHGDTVLVPNPSYPIHIYGAVIAGAQVRSVPLVEGVDFFNELERAIRESYPKPKMMILGFPSNPTAQCVELEFFEKVVALAKRYDVLVVHDLAYADIVYDGWKAPSIMQVPGARDVAVEFFTLSKSYNMAGWRIGFMVGNKTLVSALARIKSYHDYGTFTPLQVAAIAALEGDQQCVRDIAEQYKRRRYVLVKGLHEAGWMVEMPKASMYVWAKIPEPYAAMGSLEFAKKLLNEAKVCVSPGIGFGDYGDTHVRFALIENRDRIRQAIRGIKAMFRADGLLPASSKHIHENAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DH1</accession>
    <name>Q32DH1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_2570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000955028.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404125.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DH1"/>
    <dbReference type="STRING" id="300267.SDY_2570"/>
    <dbReference type="EnsemblBacteria" id="ABB62634">
        <property type="protein sequence ID" value="ABB62634"/>
        <property type="gene ID" value="SDY_2570"/>
    </dbReference>
    <dbReference type="GeneID" id="66673758"/>
    <dbReference type="KEGG" id="sdy:SDY_2570"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3100"/>
    <dbReference type="HOGENOM" id="CLU_056175_0_0_6"/>
    <dbReference type="OMA" id="LAMWITY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="314" mass="33616" checksum="5868054ECEBA6079" modified="2005-12-06" version="1">MLTFFIGDLLPIIVIMLLGYFSGRRETFSEDQARAFNKLVLNYALPAALFVSITRANREMIFADTRLTLVSLVVIVGCFFFSWFGCYKFFKRTHAEAAVCALIAGSPTIGFLGFAVLDPIYGDSVSTGLVVAIISIIVNAITIPIGLYLLNPSSGADGKKNSNLSALISAAKEPVVWAPVLATILVLVGVKIPAAWDPTFNLIAKANSGVAVFAAGLTLAAHKFEFSAEIAYNTFLKLILMPLALLLVGMACHLNSEHLQMMVLAGALPPAFSGIIIASRFNVYTRTGTASLAVSVLGFVVTAPLWIYVSRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DK0</accession>
    <name>Q32DK0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PapC_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DK0"/>
    <dbReference type="STRING" id="300267.SDY_2536"/>
    <dbReference type="EnsemblBacteria" id="ABB62605">
        <property type="protein sequence ID" value="ABB62605"/>
        <property type="gene ID" value="SDY_2536"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2536"/>
    <dbReference type="HOGENOM" id="CLU_009120_2_2_6"/>
    <dbReference type="OMA" id="NAQCEIR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015473">
        <property type="term" value="F:fimbrial usher porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000015">
        <property type="entry name" value="Fimb_usher"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042186">
        <property type="entry name" value="FimD_plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025949">
        <property type="entry name" value="PapC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043142">
        <property type="entry name" value="PapC-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30451">
        <property type="entry name" value="PTHR30451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13953">
        <property type="entry name" value="PapC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00577">
        <property type="entry name" value="Usher"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PapC_C" evidence="1">
        <location>
            <begin position="89"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="199" mass="20989" checksum="DA1BD02197EB6D50" modified="2005-12-06" version="1">MGGTRLLIDADGVAGVPVEGNGAAVYTNMFGKAVVADVNNYYRNQAYIDLNNLPENAEVTQSVVQATLTEGAIGYRKFSVISGQKAMAVLRLQDGSYPPFGAEVKNDNAQNVGLVDDDGNVYLAGVKPGEHMTVSWGGVAHCDIHLPDPLPADLFNGLLLPCQQTGAISPSVPNEIKPVIQEQTQQVTPTEPPVSVSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DL0</accession>
    <name>Q32DL0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001089222.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404086.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DL0"/>
    <dbReference type="SMR" id="Q32DL0"/>
    <dbReference type="STRING" id="300267.SDY_2525"/>
    <dbReference type="EnsemblBacteria" id="ABB62595">
        <property type="protein sequence ID" value="ABB62595"/>
        <property type="gene ID" value="SDY_2525"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2525"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3040"/>
    <dbReference type="HOGENOM" id="CLU_097152_0_0_6"/>
    <dbReference type="OMA" id="TQSQFEV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007411">
        <property type="entry name" value="EpmC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04315">
        <property type="entry name" value="EpmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="182" mass="21146" checksum="ADD70D0BE3E3198A" modified="2005-12-06" version="1">MNSTHHYEQLIEIFNSCFADDFNTRLIKGDDEPIYLPADAEVPYNRIVFAHGFYASAIHEISHWCIAGKARRELVDFGYWYCPDGRDAQTQSQFEDVEVKPQALDWLFCVAAGYPFNVSCDNLEGDFEPDRVVFQRRVHAQVMDYLTNGIPERPARFIKALQNYYHTPELTAEQFPWPEALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DN9</accession>
    <name>Q32DN9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yfcE</name>
        <name evidence="5" type="ordered locus">SDY_2496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404057.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DN9"/>
    <dbReference type="STRING" id="300267.SDY_2496"/>
    <dbReference type="EnsemblBacteria" id="ABB62566">
        <property type="protein sequence ID" value="ABB62566"/>
        <property type="gene ID" value="SDY_2496"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2496"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3008"/>
    <dbReference type="HOGENOM" id="CLU_063749_1_1_6"/>
    <dbReference type="OMA" id="DILYHGP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020935">
        <property type="entry name" value="PdiEstase_YfcE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01269">
        <property type="entry name" value="UPF0025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="184" mass="20106" checksum="15C5AA14F95405A9" modified="2005-12-06" version="1">MMKLMFASDIHGSLPATERVLELFAQSGAQWLVILGDVLNHGPRNALPEGYAPAKVAERLNEVAHKVIAVRGNCDSEVDQMLLHFPITAPWQQVLLEKQRLFLTHGHLFGPENLPALNQNDVLVFGHTHLPVAEQRGEIFHFNPGSVSIPKGGNPASYGMLDNDVLSVIALNDQSIIAQVAINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DX0</accession>
    <name>Q32DX0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DX0"/>
    <dbReference type="STRING" id="300267.SDY_2412"/>
    <dbReference type="EnsemblBacteria" id="ABB62485">
        <property type="protein sequence ID" value="ABB62485"/>
        <property type="gene ID" value="SDY_2412"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2412"/>
    <dbReference type="HOGENOM" id="CLU_076276_5_4_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="47" mass="5528" checksum="C7D336F9EF5489B1" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDEMR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E03</accession>
    <name>IF1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infA</name>
        <name type="ordered locus">SDY_2377</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001040187.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403943.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E03"/>
    <dbReference type="SMR" id="Q32E03"/>
    <dbReference type="STRING" id="300267.SDY_2377"/>
    <dbReference type="EnsemblBacteria" id="ABB62452">
        <property type="protein sequence ID" value="ABB62452"/>
        <property type="gene ID" value="SDY_2377"/>
    </dbReference>
    <dbReference type="GeneID" id="60371679"/>
    <dbReference type="GeneID" id="64296173"/>
    <dbReference type="GeneID" id="67414644"/>
    <dbReference type="KEGG" id="sdy:SDY_2377"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2871"/>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_6"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="PRO" id="PR:Q32E03"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000263871" description="Translation initiation factor IF-1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="S1-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <sequence length="72" mass="8250" checksum="CDFE0845C4CBE147" modified="2005-12-06" version="1">MAKEDNIEMQGTVLETLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVTVELTPYDLSKGRIVFRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E19</accession>
    <name>Q32E19_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pyruvate formate-lyase-activating enzyme</fullName>
            <ecNumber evidence="12">1.97.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pflA</name>
        <name evidence="14" type="ordered locus">SDY_2359</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:19225"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12190"/>
            <dbReference type="Rhea" id="RHEA-COMP:12191"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
            <dbReference type="EC" id="1.97.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000111043.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403927.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E19"/>
    <dbReference type="SMR" id="Q32E19"/>
    <dbReference type="STRING" id="300267.SDY_2359"/>
    <dbReference type="EnsemblBacteria" id="ABB62436">
        <property type="protein sequence ID" value="ABB62436"/>
        <property type="gene ID" value="SDY_2359"/>
    </dbReference>
    <dbReference type="GeneID" id="67414210"/>
    <dbReference type="KEGG" id="sdy:SDY_2359"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2846"/>
    <dbReference type="HOGENOM" id="CLU_058969_1_0_6"/>
    <dbReference type="OMA" id="IGVPNKR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012838">
        <property type="entry name" value="PFL1_activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034465">
        <property type="entry name" value="Pyruvate_for-lyase_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00278">
        <property type="entry name" value="pyruvate_formate-lyase_activas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02493">
        <property type="entry name" value="PFLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="16"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB62436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="246" mass="28204" checksum="486E06A9CE97BF37" modified="2005-12-06" version="1">MSVIGRIHSFESCGTVDGPGIRFITFFQGCLMRCLYCHNRDTWDTHGGKEVTVEDLMKEVVTYRHFMNASGGGVTASGGEAILQAEFVRDWFRACKKEGIHTCLDTNGFVRRYDPVIDELLEVTDLVMLDLKQMNDEIHQNLVGVSNHRTLEFAKYLANKNVKVWIRYVVVPGWSDDDDSAHRLGEFTRDMGNVEKIELLPYHELGKHKWVAMGEEYKLDGVKPPKKETMERVKGILEQYGHKVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EP8</accession>
    <name>Q32EP8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EP8"/>
    <dbReference type="EnsemblBacteria" id="ABB62207">
        <property type="protein sequence ID" value="ABB62207"/>
        <property type="gene ID" value="SDY_2117"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2117"/>
    <dbReference type="HOGENOM" id="CLU_2496185_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="8917" checksum="7D50267EF375343D" modified="2005-12-06" version="1">MGTGKNFPGDAMKRGYVTVTLGSDFDASTIKKGDPVYVVVPTDESIKVPLGGFMSTSVSGKNVVLTNAEFTGAGDADGNAEISWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EQ4</accession>
    <name>Q32EQ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysine-specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lysP</name>
        <name evidence="8" type="ordered locus">SDY_2110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000253273.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403692.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EQ4"/>
    <dbReference type="SMR" id="Q32EQ4"/>
    <dbReference type="STRING" id="300267.SDY_2110"/>
    <dbReference type="EnsemblBacteria" id="ABB62201">
        <property type="protein sequence ID" value="ABB62201"/>
        <property type="gene ID" value="SDY_2110"/>
    </dbReference>
    <dbReference type="GeneID" id="66673948"/>
    <dbReference type="KEGG" id="sdy:SDY_2110"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2540"/>
    <dbReference type="HOGENOM" id="CLU_007946_9_2_6"/>
    <dbReference type="OMA" id="AMFSTAN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="21"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="489" mass="53576" checksum="144FAFC01F2F8E7A" modified="2005-12-06" version="1">MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYMLIGLMVYFLMTSLGELAAYMPVSGSFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFSLIKVTTVIVFIIVGVLMIIGIFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPAKNIPRAVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGMYASTRMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVLQGHDINDLPYRSGFFPLGPIFAFILCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLIIWFGYKLIKGTHFVRYSEMKFPQNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ER2</accession>
    <name>Q32ER2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_1665</name>
        <name evidence="4" type="ordered locus">SDY_2102</name>
        <name evidence="5" type="ordered locus">SDY_4303</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61786">
        <property type="protein sequence ID" value="ABB61786"/>
        <property type="gene ID" value="SDY_1665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62193">
        <property type="protein sequence ID" value="ABB62193"/>
        <property type="gene ID" value="SDY_2102"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64199">
        <property type="protein sequence ID" value="ABB64199"/>
        <property type="gene ID" value="SDY_4303"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1665"/>
    <dbReference type="KEGG" id="sdy:SDY_2102"/>
    <dbReference type="KEGG" id="sdy:SDY_4303"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="8350" checksum="D3B36CF1E384C602" modified="2005-12-06" version="1">MTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKLLSFSKSVELHDRVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EX5</accession>
    <name>Q32EX5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycfT</name>
        <name evidence="3" type="ordered locus">SDY_2035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000810286.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403621.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EX5"/>
    <dbReference type="STRING" id="300267.SDY_2035"/>
    <dbReference type="EnsemblBacteria" id="ABB62130">
        <property type="protein sequence ID" value="ABB62130"/>
        <property type="gene ID" value="SDY_2035"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2035"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2449"/>
    <dbReference type="HOGENOM" id="CLU_023915_5_0_6"/>
    <dbReference type="OMA" id="KVVHFAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="357" mass="40711" checksum="09DCA0857F5CB4C7" modified="2005-12-06" version="1">MKQKELWINQIKGLCICLVVIYHSVITFYPHMTTFQHPLSEVLSKCWICFNLYLAPFRMPVFFFISGYLIRRYIDSVPWGNCLDKRIWSIFWVLALWGVVQWLALSALNQWLAPERDLSNASNAAYADSTGEFLHGMITASTSLWYLYALIVYFVVCKIFSRLALPLFALFVLLSVAVNFVPTPWWGMNSVIRNLPYYSLGAWFGATLMTYVKEVPLRRHLLMASLLTVLAVGAWLFTISLLLSLVSIVVIMKLFYQYEQRFGMRSTSLLNVIGSNTIAIYTTHRILVEIFSLSLIPQMNAGHWSPQVELALLLVYPFVSLLICTLAGLLVIKLSQRAFSDLLFSPPSLPAAVSYSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F28</accession>
    <name>HTPX_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protease HtpX</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein HtpX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">htpX</name>
        <name type="ordered locus">SDY_1977</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000984517.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403568.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F28"/>
    <dbReference type="SMR" id="Q32F28"/>
    <dbReference type="STRING" id="300267.SDY_1977"/>
    <dbReference type="MEROPS" id="M48.002"/>
    <dbReference type="EnsemblBacteria" id="ABB62077">
        <property type="protein sequence ID" value="ABB62077"/>
        <property type="gene ID" value="SDY_1977"/>
    </dbReference>
    <dbReference type="GeneID" id="66674281"/>
    <dbReference type="KEGG" id="sdy:SDY_1977"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2387"/>
    <dbReference type="HOGENOM" id="CLU_042266_1_0_6"/>
    <dbReference type="OMA" id="AVCCTEG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000020943" description="Protease HtpX">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <sequence length="293" mass="31957" checksum="132B39F6392DD5BF" modified="2005-12-06" version="1">MMRIALFLLTNLAVMVVFGLVLSLTGIQSSSVQGLMIMALLFGFGGSFVSLLMSKWMALRSVGGEVIEQPRNERERWLVNTVATQARQAGIAMPQVAIYHAPDINAFATGARRDASLVAVSTGLLQNMSPDEAEAVIAHEISHIANGDMVTMTLIQGVVNTFVIFISRILAQLAAGFMGGNRDEGEESNGNPLIYFAVATVLELVFGILASIITMWFSRHREFHADAGSAKLVGREKMIAALQRLKTSYEPQEATSMMAFCINGKSKSLSELFMTHPPLDKRIEALRTGEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F78</accession>
    <name>Q32F78_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F78"/>
    <dbReference type="STRING" id="300267.SDY_1921"/>
    <dbReference type="EnsemblBacteria" id="ABB62027">
        <property type="protein sequence ID" value="ABB62027"/>
        <property type="gene ID" value="SDY_1921"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1921"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27474" checksum="794CB4CF1C5CF1A5" modified="2005-12-06" version="1">MAHIRTRETYGARRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQLGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHHMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FB0</accession>
    <name>Q32FB0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclopropane fatty acyl phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cfa</name>
        <name evidence="3" type="ordered locus">SDY_1887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000098908.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403486.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FB0"/>
    <dbReference type="STRING" id="300267.SDY_1887"/>
    <dbReference type="EnsemblBacteria" id="ABB61995">
        <property type="protein sequence ID" value="ABB61995"/>
        <property type="gene ID" value="SDY_1887"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1887"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2270"/>
    <dbReference type="HOGENOM" id="CLU_026434_6_0_6"/>
    <dbReference type="OMA" id="LHCITAQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="382" mass="43900" checksum="2DE73318A3431553" modified="2005-12-06" version="1">MSSSCIEEVSVPDDNWYRIANELLSRAGIAINGSAPADIRVKNPDFFKRVLQEGSLGLGESYMDGWWECDRLDMFFSKVLRAGLENQLPHHFKDTLRIAGTRLFNLQSKKRAWIVGKEHYDLGNDLFSRMLDPFMQYSCAYWKDADNLESAQQAKLKMICEKLQLKPGMRVLDIGCGWGGLAHYMASNYDVSVVGVTISAEQQKMAQERCEGLDVTILLQDYRDLNDQFDRIVSVGMFEHVGPKNYDTYFAVVDRNLKPEGIFLLHTIGSKKTDLNVDPWINKYIFPNGCLPSVRQIAQSSESHFVMEDWHNFGADYDTTLMAWYEQFLAAWPEIADNYSERFKRMFTYYLNACAGAFRARDIQLWQVVFSRGVKNGLRVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FB9</accession>
    <name>Q32FB9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="4 8">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gloA</name>
        <name evidence="10" type="ordered locus">SDY_1877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(R)-S-lactoylglutathione = glutathione + methylglyoxal</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="8">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001237796.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403477.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FB9"/>
    <dbReference type="SMR" id="Q32FB9"/>
    <dbReference type="STRING" id="300267.SDY_1877"/>
    <dbReference type="EnsemblBacteria" id="ABB61986">
        <property type="protein sequence ID" value="ABB61986"/>
        <property type="gene ID" value="SDY_1877"/>
    </dbReference>
    <dbReference type="GeneID" id="66674457"/>
    <dbReference type="KEGG" id="sdy:SDY_1877"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2256"/>
    <dbReference type="HOGENOM" id="CLU_046006_8_1_6"/>
    <dbReference type="OMA" id="NWGTESY"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="9">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="14920" checksum="A53FC5412B9A6CE3" modified="2005-12-06" version="1">MRLLHTMLRVGDLQRSIDFYTKVLGMKLLRTSENPEYKYSLAFVGYGPETEEAVIELTYNWGVDKYELGTAYGHIALSVDNAAEACEKIRQNGGNVTREAGPVKGGTTVIAFVEDPDGYKIELIEEKDAGRGLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FE2</accession>
    <name>Q32FE2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion-translocating oxidoreductase complex subunit G</fullName>
            <ecNumber evidence="6">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rsx electron transport complex subunit G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsxG</name>
        <name evidence="9" type="ordered locus">SDY_1854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnfG family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000920809.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403454.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FE2"/>
    <dbReference type="STRING" id="300267.SDY_1854"/>
    <dbReference type="EnsemblBacteria" id="ABB61963">
        <property type="protein sequence ID" value="ABB61963"/>
        <property type="gene ID" value="SDY_1854"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1854"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2233"/>
    <dbReference type="HOGENOM" id="CLU_077882_1_0_6"/>
    <dbReference type="OMA" id="YSGAIHL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00479">
        <property type="entry name" value="RsxG_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010209">
        <property type="entry name" value="Ion_transpt_RnfG/RsxG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36118">
        <property type="entry name" value="PTHR36118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006091">
        <property type="entry name" value="E_trnsport_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01947">
        <property type="entry name" value="rnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220696" description="Ion-translocating oxidoreductase complex subunit G" evidence="7">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="8">
        <location>
            <begin position="99"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="206" mass="21854" checksum="678CE05F4280F24C" modified="2005-12-06" version="1">MLKTIRKHGITLALFAAGSTGLTAAINQMTKTTIAEQASLQQKALFEQVLPAERYNNALAQSCYLVTAPELGKGGHRVYIAKQDDKPVAAVLEATAPDGYSGAIQLLVGADFNGTVLGTRVTEHHETPGLGDKIELRLSDWITHFAGKKISGADDAHWAVKKDGGDFDQFTGATITPRAVVNAVKRAGLYAQTLPAQLSQLPACGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FG4</accession>
    <name>Q32FG4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ydgA</name>
        <name evidence="1" type="ordered locus">SDY_1830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001043359.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403432.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FG4"/>
    <dbReference type="STRING" id="300267.SDY_1830"/>
    <dbReference type="EnsemblBacteria" id="ABB61941">
        <property type="protein sequence ID" value="ABB61941"/>
        <property type="gene ID" value="SDY_1830"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1830"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2203"/>
    <dbReference type="HOGENOM" id="CLU_029683_2_0_6"/>
    <dbReference type="OMA" id="QYANGQV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010352">
        <property type="entry name" value="DUF945"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06097">
        <property type="entry name" value="DUF945"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="502" mass="54634" checksum="698B969E1773A848" modified="2005-12-06" version="1">MNKSLVAVGVIVALGVVWTGGAWYTGKKIETHLEDMVAQANAQLKLTAPESNLEVSYQNYHRGVFSSQLQLLVKPIAGKENPWIKSGQSVIFNESVDHGPFPLAQLKKLNLIPSMASIQTTLVNNEVSKPLFDMAKGETPFEINSRIGYSGDSSSDISLKPLNYEQKDEKVAFSGGEFQLNADRGGKAISLSGEAQSGWIDAVNEYNQKVQLTFNNLKTDGSSTLASFGERVGNQKLSLEKMTISVEGKELALLEGMEISGKSDLVNDGKTINSQLDYSLNSLKVQNQDLGSGKLTLKVGQIDGEAWHQFSQQYNAQTPALLAQPEIANNPELYQEKVTEAFFSALPLMLKGDPVITIAPLSWKNSQGESALNLSLFLKDPATTKEAPQTLAQEVDRSVKSLDAKLTIPVDMATELMTQVAKLEGYQEDQAKKLAKQQVEGASAMGQMFRLTTLQDNTITTSLQYANGQITLNGQKMPLEDFVGMFAMPALNVPVVPAIPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FJ3</accession>
    <name>Q32FJ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_1801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FJ3"/>
    <dbReference type="EnsemblBacteria" id="ABB61912">
        <property type="protein sequence ID" value="ABB61912"/>
        <property type="gene ID" value="SDY_1801"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1801"/>
    <dbReference type="HOGENOM" id="CLU_010245_0_2_6"/>
    <dbReference type="OMA" id="NICTRTA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PTHR32057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="196" mass="21247" checksum="D6A4E7A8496340D7" modified="2005-12-06" version="1">MTLSFITRWRDELPATYTALSPTPLNNARLIWHNTELANTMSIPSSLFKNGAGVWGGETLLPSMSLLAQVYSGHQFGIWAGQLGDGRGILLGEQLLADGTTMDWHLKGAGLTPYSRMGDGRAVLRSTIRESLVSEAMHYLGIPTTRALSIVTSDSPVYRETVEPGAMLMRVAPSHALWSFRTFLLSPRAGKGSSVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FJ7</accession>
    <name>PSRP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate synthase regulatory protein</fullName>
            <shortName evidence="1">PEP synthase regulatory protein</shortName>
            <shortName evidence="1">PSRP</shortName>
            <ecNumber evidence="1">2.7.11.33</ecNumber>
            <ecNumber evidence="1">2.7.4.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pyruvate, water dikinase regulatory protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppsR</name>
        <name type="ordered locus">SDY_1797</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[pyruvate, water dikinase] + ADP = [pyruvate, water dikinase]-phosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46020"/>
            <dbReference type="Rhea" id="RHEA-COMP:11425"/>
            <dbReference type="Rhea" id="RHEA-COMP:11426"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[pyruvate, water dikinase]-phosphate + H(+) + phosphate = [pyruvate, water dikinase] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48580"/>
            <dbReference type="Rhea" id="RHEA-COMP:11425"/>
            <dbReference type="Rhea" id="RHEA-COMP:11426"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="EC" id="2.7.4.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.33" evidence="1"/>
    <dbReference type="EC" id="2.7.4.28" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000368046.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403399.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FJ7"/>
    <dbReference type="SMR" id="Q32FJ7"/>
    <dbReference type="STRING" id="300267.SDY_1797"/>
    <dbReference type="EnsemblBacteria" id="ABB61908">
        <property type="protein sequence ID" value="ABB61908"/>
        <property type="gene ID" value="SDY_1797"/>
    </dbReference>
    <dbReference type="GeneID" id="66674403"/>
    <dbReference type="KEGG" id="sdy:SDY_1797"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2169"/>
    <dbReference type="HOGENOM" id="CLU_046206_1_0_6"/>
    <dbReference type="OMA" id="YAQCEFE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01062">
        <property type="entry name" value="PSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005177">
        <property type="entry name" value="Kinase-pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026530">
        <property type="entry name" value="PSRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756">
        <property type="entry name" value="PTHR31756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03618">
        <property type="entry name" value="Kinase-PPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000196711" description="Phosphoenolpyruvate synthase regulatory protein">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01062"/>
        </source>
    </evidence>
    <sequence length="277" mass="31211" checksum="25508DEEC2E342CA" modified="2005-12-06" version="1">MDNAVDRHVFYISDGTAITAEVLGHAVMSQFPVTISSITLPFVENESRARAVKDQIDAIYHQTGVRPLVFYSIVLPEIRAIILQSEGFCQDIVQALVAPLQQEMKLDPTPIAHRTHGLNPNNLNKYDARIAAIDYTLAHDDGISLRNLDQAQVILLGVSRCGKTPTSLYLAMQFGIRAANYPFIADDMDNLVLPASLKPLQHKLFGLTIDPERLAAIREERRENSRYASLRQCRMEVAEVEALYRKNQIPWINSTNYSVEEIATKILDIMGLSRRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FJ8</accession>
    <name>Q32FJ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FJ8"/>
    <dbReference type="EnsemblBacteria" id="ABB61907">
        <property type="protein sequence ID" value="ABB61907"/>
        <property type="gene ID" value="SDY_1796"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1796"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="TERADYG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="41"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="236" mass="26732" checksum="14E119993BA38B4E" modified="2005-12-06" version="1">MVIVGVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FM5</accession>
    <name>Q32FM5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydcA</name>
        <name evidence="2" type="ordered locus">SDY_1763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000731831.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403371.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FM5"/>
    <dbReference type="EnsemblBacteria" id="ABB61880">
        <property type="protein sequence ID" value="ABB61880"/>
        <property type="gene ID" value="SDY_1763"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1763"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2124"/>
    <dbReference type="HOGENOM" id="CLU_210702_0_0_6"/>
    <dbReference type="OMA" id="NMADARG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220958" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="57" mass="5872" checksum="E3EEC638FD021B75" modified="2005-12-06" version="1">MKKLALILFMGTLVSFYADAGRKPCSGSKGGISHCTAGGKFVCNDGSISASKKICTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FW0</accession>
    <name>Q32FW0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1,4-dihydroxy-2-naphthoyl-CoA hydrolase</fullName>
            <shortName evidence="1">DHNA-CoA hydrolase</shortName>
            <ecNumber evidence="1">3.1.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DHNA-CoA thioesterase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">menI</name>
        <name evidence="3" type="ordered locus">SDY_1674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26309"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="3.1.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer. Dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.28" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000637986.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403286.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FW0"/>
    <dbReference type="SMR" id="Q32FW0"/>
    <dbReference type="STRING" id="300267.SDY_1674"/>
    <dbReference type="EnsemblBacteria" id="ABB61795">
        <property type="protein sequence ID" value="ABB61795"/>
        <property type="gene ID" value="SDY_1674"/>
    </dbReference>
    <dbReference type="GeneID" id="66674421"/>
    <dbReference type="KEGG" id="sdy:SDY_1674"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2020"/>
    <dbReference type="HOGENOM" id="CLU_089876_13_1_6"/>
    <dbReference type="OMA" id="TTQVWQI"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER01033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061522">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01936">
        <property type="entry name" value="MenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030863">
        <property type="entry name" value="MenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="50"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="106"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile or proton acceptor" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="136" mass="14911" checksum="47BE23EFD51FF215" modified="2005-12-06" version="1">MIWKRKITLEALNAMGEGNMVGLLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FZ3</accession>
    <name>Q32FZ3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione-binding protein GsiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sapA</name>
        <name evidence="9" type="ordered locus">SDY_1638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001250231.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403253.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FZ3"/>
    <dbReference type="STRING" id="300267.SDY_1638"/>
    <dbReference type="EnsemblBacteria" id="ABB61762">
        <property type="protein sequence ID" value="ABB61762"/>
        <property type="gene ID" value="SDY_1638"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1638"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1974"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_0_6"/>
    <dbReference type="OMA" id="NQYVRLV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220827" description="Glutathione-binding protein GsiB" evidence="7">
        <location>
            <begin position="22"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="8">
        <location>
            <begin position="79"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="547" mass="61541" checksum="01AFB93E4B790FF3" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G76</accession>
    <name>Q32G76_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_1543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G76"/>
    <dbReference type="STRING" id="300267.SDY_1543"/>
    <dbReference type="EnsemblBacteria" id="ABB61679">
        <property type="protein sequence ID" value="ABB61679"/>
        <property type="gene ID" value="SDY_1543"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1543"/>
    <dbReference type="HOGENOM" id="CLU_019375_0_1_6"/>
    <dbReference type="OMA" id="YFCTTII"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="386" mass="40152" checksum="AE81043860479008" modified="2005-12-06" version="1">MIVMPLVFASILSAVARLHNASQLGKISFLTIGTLLFTTLIAALVGVLVTNLFGLTAEGLVQGGAETARLNAIESNYVGKVSDLSVPQLVLSFIPKNPFADLTGANPTSIISVVIFAAFLGVAALKLLKDDAPKGERVLTAIDTLQSWVMKLVRLVMQLTPYGVLALMTKVVAGSNLQDIIKLGSFVVASYLGLLIMFAVHGILLGINGVSPLKYFRKVWPVLTFAFTSRSSAASIPLNVEAQTRRLGVPESIASFAASFGATIGQNGCAGLYPAMLAVMVAPTVGINPLDPMWIATLVGIVTVSSAGVAGVGGGATFAALIVLPAMGLPVTLVALLISVEPLIDMGRTALNVSGSMTAGTLTSQWLKQTDKAILDSEDDAELAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G82</accession>
    <name>Q32G82_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G82"/>
    <dbReference type="EnsemblBacteria" id="ABB61673">
        <property type="protein sequence ID" value="ABB61673"/>
        <property type="gene ID" value="SDY_1537"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1537"/>
    <dbReference type="HOGENOM" id="CLU_076276_5_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7547" checksum="8364DE3FEBD7EEA1" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G91</accession>
    <name>Q32G91_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xthA</name>
        <name evidence="4" type="ordered locus">SDY_1527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000673907.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403155.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G91"/>
    <dbReference type="STRING" id="300267.SDY_1527"/>
    <dbReference type="EnsemblBacteria" id="ABB61664">
        <property type="protein sequence ID" value="ABB61664"/>
        <property type="gene ID" value="SDY_1527"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1527"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1827"/>
    <dbReference type="HOGENOM" id="CLU_027539_0_3_6"/>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00727">
        <property type="entry name" value="AP_NUCLEASE_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="268" mass="30906" checksum="8B45753D99A1D516" modified="2005-12-06" version="1">MKFVSFNINGLRARPHQLEAIVDKHQPDVIGLQETKVHDDMFPLEDVAKLGYNVFYHGQKGHYGVALLTKETPIAVRRGFPGDGEEAQRRIIMAEIPSPLGNVTVINGYFPQGERRDHPIKFPAKAQFYQNLQNYLETELKRDNPVLIMGDMNISPGDLDIGIGEENRKRWLRTGKCSFLPEEREWMERLMSWGLVDTFRHANPQTADRFSWFDYRSKGFDDNRGLRIDLLLASQPLAECCVETGIDYEIRSMEKPSDHAPVWATFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GB1</accession>
    <name>Q32GB1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ansA</name>
        <name evidence="9" type="ordered locus">SDY_1506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001170167.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403135.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GB1"/>
    <dbReference type="STRING" id="300267.SDY_1506"/>
    <dbReference type="EnsemblBacteria" id="ABB61644">
        <property type="protein sequence ID" value="ABB61644"/>
        <property type="gene ID" value="SDY_1506"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1506"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1799"/>
    <dbReference type="HOGENOM" id="CLU_019134_2_3_6"/>
    <dbReference type="OMA" id="AIVPKLM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="8">
        <location>
            <begin position="213"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="3">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="338" mass="37226" checksum="6ED8C56DB0E8F8DA" modified="2005-12-06" version="1">MQKKSIYVAYTGGTIGMQRSEQGYIPVSGHLQRQLALMPEFHRPEMPDFTIHEYTPLMDSSDMTPEDWQHIAEDIKAHYDDYDGFVILHGTDTMAYTASALSFMLENLGKPVIVTGSQIPLAELRSDGQINLLNALYVAANYPINEVTLFFNNRLYRGNRTTKAHADGFDAFASPNLPPLLEAGIHIRRLNTPPAPHGERELIVHPITPQPIGVVTIYPGISADVVRNFLRQPVKALILRSYGVGNAPQNKAFLQELQEASDRGIVVVNLTQCMSGKVNMGGYATGNALAHAGVIGGADMTVEATLTKLHYLLSQELDTETIRKAMSQNLRGELTPDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GC7</accession>
    <name>MSRB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="1">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msrB</name>
        <name type="ordered locus">SDY_1489</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001284607.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403119.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GC7"/>
    <dbReference type="SMR" id="Q32GC7"/>
    <dbReference type="STRING" id="300267.SDY_1489"/>
    <dbReference type="EnsemblBacteria" id="ABB61628">
        <property type="protein sequence ID" value="ABB61628"/>
        <property type="gene ID" value="SDY_1489"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1489"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1777"/>
    <dbReference type="HOGENOM" id="CLU_031040_8_5_6"/>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000068292" description="Peptide methionine sulfoxide reductase MsrB">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="MsrB" evidence="2">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01126"/>
        </source>
    </evidence>
    <sequence length="137" mass="15405" checksum="7B8BD83CAEAE0F70" modified="2005-12-06" version="1">MANKPSAEELKKNLSDMQFYVTQNHGTEPPFTGRLLHNKRDGVYHCLICDAPLFHSQTKYDSGCGWPSFYEPVSEESIRYIKDLSHGVQRIEIRCGNCDAHLGHVFPDGPQPTGERYCVNSASLRFTDGENGEEING</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GE4</accession>
    <name>Q32GE4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000177505.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403102.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GE4"/>
    <dbReference type="STRING" id="300267.SDY_1472"/>
    <dbReference type="EnsemblBacteria" id="ABB61611">
        <property type="protein sequence ID" value="ABB61611"/>
        <property type="gene ID" value="SDY_1472"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1472"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1753"/>
    <dbReference type="HOGENOM" id="CLU_088602_0_0_6"/>
    <dbReference type="OMA" id="RMALNAV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="204" mass="22998" checksum="036D7EF445D0E1A0" modified="2005-12-06" version="1">MTLYQIKPLFQSLLRPTMFWLYKHHVTANHITLAALALSLITGLLLMLVAQPILFLLLPIVLFIRMALNALDGMLARECNQQTRLGAILNETGDVISDIALYLPFLFLPESNASLVILMLFCTILTEFCGLLAQTINGIRSYAGPFGKSDRALIFGLWGLAVAIYPQWMQWNNLLWSIASILLIWTAINRCRVMLPISRTCVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GF8</accession>
    <name>Q32GF8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron transport protein, ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sitB</name>
        <name evidence="5" type="ordered locus">SDY_1456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000983722.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403088.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GF8"/>
    <dbReference type="STRING" id="300267.SDY_1456"/>
    <dbReference type="EnsemblBacteria" id="ABB61597">
        <property type="protein sequence ID" value="ABB61597"/>
        <property type="gene ID" value="SDY_1456"/>
    </dbReference>
    <dbReference type="GeneID" id="58462206"/>
    <dbReference type="KEGG" id="sdy:SDY_1456"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1734"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_6"/>
    <dbReference type="OMA" id="SVWDVVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="275" mass="30075" checksum="77A800DB28A666D0" modified="2005-12-06" version="1">MMQSAGIVVNDVTVTWRNGHTALRDASFTVPSGSIAALVGVNGSGKSTLFKAIMGFVRLTSGKISVLGIPTRQALQKNLVAYVPQSEEVDWSFPVLVEDVVMMGRYGHMGMLRIAKKRDRQIVTDALERVDMVDFRHRQIGELSGGQKKRVFLARAIAQQGDVILLDEPFTGVDVKTEAKIISLLRELRAEGKTMLVSTHNLGSVTTFCDYTVMVKGTVLASGPTDTTFTAENLELAFSGVLRHVTLNGSEESIITDDERPFVAHRPSAVQREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GG6</accession>
    <name>Q32GG6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1737 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403080.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GG6"/>
    <dbReference type="EnsemblBacteria" id="ABB61589">
        <property type="protein sequence ID" value="ABB61589"/>
        <property type="gene ID" value="SDY_1448"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1448"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1722"/>
    <dbReference type="HOGENOM" id="CLU_014323_3_3_6"/>
    <dbReference type="OMA" id="AIEPEWY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013619">
        <property type="entry name" value="DUF1737"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08410">
        <property type="entry name" value="DUF1737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1737" evidence="1">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="80" mass="8954" checksum="1CC895C4FA606CF1" modified="2005-12-06" version="1">MVERTMAFKHYDVVRAAPPSDLAEKLTHKLKEGWQLFGSPVAITPYTLMQAIAAEGDVVVSGAIEPEWYYVIVLARHSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GJ0</accession>
    <name>Q32GJ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403056.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GJ0"/>
    <dbReference type="STRING" id="300267.SDY_1421"/>
    <dbReference type="EnsemblBacteria" id="ABB61565">
        <property type="protein sequence ID" value="ABB61565"/>
        <property type="gene ID" value="SDY_1421"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1421"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1691"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11104" checksum="2FB3A770D9E9D605" modified="2005-12-06" version="1">MSRKTQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGPLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLGRDILKKATAYFAQESLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GY1</accession>
    <name>Q32GY1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sensor protein</fullName>
            <ecNumber evidence="14">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">narX</name>
        <name evidence="18" type="ordered locus">SDY_1276</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="14"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000918072.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402915.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GY1"/>
    <dbReference type="STRING" id="300267.SDY_1276"/>
    <dbReference type="EnsemblBacteria" id="ABB61424">
        <property type="protein sequence ID" value="ABB61424"/>
        <property type="gene ID" value="SDY_1276"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1276"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1515"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_10_6"/>
    <dbReference type="OMA" id="AHISGRN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029095">
        <property type="entry name" value="NarX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042295">
        <property type="entry name" value="NarX-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016380">
        <property type="entry name" value="Sig_transdc_His_kin_NarX/NarQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13675">
        <property type="entry name" value="PilJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003167">
        <property type="entry name" value="STHK_NarX/NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12 14" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="17">
        <location>
            <begin position="176"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="393"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR003167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB61424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="598" mass="67085" checksum="868540FC2C85363E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HL8</accession>
    <name>Q32HL8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TonB-dependent outer membrane siderophore receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">iroN</name>
        <name evidence="13" type="ordered locus">SDY_1022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378642.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402678.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HL8"/>
    <dbReference type="STRING" id="300267.SDY_1022"/>
    <dbReference type="EnsemblBacteria" id="ABB61187">
        <property type="protein sequence ID" value="ABB61187"/>
        <property type="gene ID" value="SDY_1022"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1022"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1195"/>
    <dbReference type="HOGENOM" id="CLU_008287_18_2_6"/>
    <dbReference type="OMA" id="HPPANDL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:organic substance transport"/>
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        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BtuB-like"/>
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        <property type="entry name" value="Plug_dom_sf"/>
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        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
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    </dbReference>
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        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABB61187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="725" mass="79307" checksum="550814264A2DEF1F" modified="2005-12-06" version="1"> </sequence>
</entry>
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        </submittedName>
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        <name evidence="2" type="ordered locus">SDY_1017</name>
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        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000002716">
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220999" evidence="1">
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            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="155" mass="18022" checksum="2EFCA497444DFE6D" modified="2005-12-06" version="1">MKFIVKALICLAIMLSFTANAAEYKKYPQGEITYYKYLPKNGWKLPAGYTVEQFSSAMYKGQIRNNFPWTNQFIVRGNGVLFLANKVNKTWHVLPVDYQNLNFGRLTTHYQHVNKGDGCYFYILDGHGSDAKPILRIEENCVDMKMYRKMVAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HV5"/>
    <dbReference type="STRING" id="300267.SDY_0924"/>
    <dbReference type="EnsemblBacteria" id="ABB61100">
        <property type="protein sequence ID" value="ABB61100"/>
        <property type="gene ID" value="SDY_0924"/>
    </dbReference>
    <dbReference type="GeneID" id="58461141"/>
    <dbReference type="KEGG" id="sdy:SDY_0924"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1070"/>
    <dbReference type="HOGENOM" id="CLU_018765_3_1_6"/>
    <dbReference type="OMA" id="HHVEIKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="42"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="158"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="285"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="546" mass="60493" checksum="B47DF6B62EB03F60" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HW7</accession>
    <name>Q32HW7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PapC_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402579.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HW7"/>
    <dbReference type="STRING" id="300267.SDY_0912"/>
    <dbReference type="EnsemblBacteria" id="ABB61088">
        <property type="protein sequence ID" value="ABB61088"/>
        <property type="gene ID" value="SDY_0912"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0912"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1056"/>
    <dbReference type="HOGENOM" id="CLU_009120_4_1_6"/>
    <dbReference type="OMA" id="GAYANTN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015473">
        <property type="term" value="F:fimbrial usher porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000015">
        <property type="entry name" value="Fimb_usher"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042186">
        <property type="entry name" value="FimD_plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025949">
        <property type="entry name" value="PapC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043142">
        <property type="entry name" value="PapC-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30451">
        <property type="entry name" value="PTHR30451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13953">
        <property type="entry name" value="PapC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00577">
        <property type="entry name" value="Usher"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PapC_C" evidence="1">
        <location>
            <begin position="198"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="277" mass="29718" checksum="C3C4ABF58FC0B3C5" modified="2005-12-06" version="1">MLPRSNDSYTSKKNYAWMTSNTSIDNEGHTTQNLGLTETLLDDGNLSYSVQQGYNSEGKTANGSASMDYKGAFADARVGYNYSDNGSQQQLNYALSGSLVAHSQGITLGQSLGETNVLIAVPGAENTRVANSTGLKTDWRGYTVVPYATSYRENRIALDAASLKRNVDLENAVVNVVPTKGALVLAEFNAHAGARVLMKTTKQGIPLRFGAIATLDGVQTNSGIIDDDGSLYMAGLPAKGTITVRWGEASDQICHISYQLTEQQINSAITRMDAICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HZ4</accession>
    <name>Q32HZ4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c-type biogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ccmH</name>
        <name evidence="7" type="ordered locus">SDY_0884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Possible subunit of a heme lyase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the CcmH/CycL/Ccl2/NrfF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001211571.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402552.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HZ4"/>
    <dbReference type="STRING" id="300267.SDY_0884"/>
    <dbReference type="EnsemblBacteria" id="ABB61061">
        <property type="protein sequence ID" value="ABB61061"/>
        <property type="gene ID" value="SDY_0884"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0884"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1019"/>
    <dbReference type="HOGENOM" id="CLU_036074_0_0_6"/>
    <dbReference type="OMA" id="KIWFVSG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005616">
        <property type="entry name" value="CcmH/CycL/Ccl2/NrfF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038297">
        <property type="entry name" value="CcmH/CycL/NrfF/Ccl2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03918">
        <property type="entry name" value="CcmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011021091" description="Cytochrome c-type biogenesis protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="350" mass="39085" checksum="74B58CEAF034D7C0" modified="2005-12-06" version="1">MRFLLGVLMLMISGSALATIDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIVDYMVARYGNFVTYDPPLTPLTVLLWVLPVVAIGIGGWVIYARSRRRVRVVPEAFPEQSVPEGKRAGYVVYLPGILVALIVAGVSYYQTGNYQQVKIWQQATAQAPALLDRALDPKADPLNEEEMSRLALGMRTQLQKNPGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSAPNDNRLGGELLRQLVRTDHSNIRVLSMYAFNAFEQQRFGEAVAAWEMMLKLLPANDTRRAVIERSIAQAMQHLLPQESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I35</accession>
    <name>Q32I35_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I35"/>
    <dbReference type="EnsemblBacteria" id="ABB61022">
        <property type="protein sequence ID" value="ABB61022"/>
        <property type="gene ID" value="SDY_0840"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0840"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="97" mass="10727" checksum="ADDB8CB63D3B672C" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITVFFLNGYSGGIYDAILLSPSWSCSGFCIFIPFCPNGIRGRTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I77</accession>
    <name>Q32I77_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybiC</name>
        <name evidence="2" type="ordered locus">SDY_0798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000443496.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402469.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I77"/>
    <dbReference type="STRING" id="300267.SDY_0798"/>
    <dbReference type="EnsemblBacteria" id="ABB60980">
        <property type="protein sequence ID" value="ABB60980"/>
        <property type="gene ID" value="SDY_0798"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0798"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.921"/>
    <dbReference type="HOGENOM" id="CLU_040452_1_0_6"/>
    <dbReference type="OMA" id="HDIGMAS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="361" mass="38874" checksum="A3BB900DBA1621CE" modified="2005-12-06" version="1">MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKIVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDDFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALAAMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCSAQTEAFAEWVKASPHDDDKPILLPGEWEVNTRRERQEQGIPLDAGSWQAICDAARQIGMSEETLQAFCQQLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IE7</accession>
    <name>Q32IE7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402399.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IE7"/>
    <dbReference type="STRING" id="300267.SDY_0726"/>
    <dbReference type="EnsemblBacteria" id="ABB60910">
        <property type="protein sequence ID" value="ABB60910"/>
        <property type="gene ID" value="SDY_0726"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0726"/>
    <dbReference type="HOGENOM" id="CLU_092063_0_0_6"/>
    <dbReference type="OMA" id="EGIDMLW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006437">
        <property type="entry name" value="Phage_terminase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035412">
        <property type="entry name" value="Terminase_L_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04466">
        <property type="entry name" value="Terminase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01547">
        <property type="entry name" value="phage_term_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terminase_3" evidence="1">
        <location>
            <begin position="33"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="272" mass="31273" checksum="8E43C72CC434722F" modified="2005-12-06" version="1">MMAMESVTSMTSTLTSKPTLNPALRSFWTMRARNKVLYGGRSSSKSWDAAGIAIFLSNKYTLRFCCARQIQNKIEESVYTLLKIQIDRFGLRHRFRILNNKIINRVTGSEFVFYGLWRNIEEIKSLEGIDVLWLEEAHALTEYQWKILEPTIRKEGSECWFIFNPGLVTDFVWRNFVVDPPEGTLIRKINYDENPFLSDTMLKVIDAARRRDPDGFKHVYEGVPESDDDAAIIKLSWIEAAVDAHKTLNFEPSGRKRIGFDVADSGTDKCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IG6</accession>
    <name>Q32IG6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ordered locus">SDY_0706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001265469.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402380.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IG6"/>
    <dbReference type="STRING" id="300267.SDY_0706"/>
    <dbReference type="EnsemblBacteria" id="ABB60891">
        <property type="protein sequence ID" value="ABB60891"/>
        <property type="gene ID" value="SDY_0706"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0706"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.817"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_6"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="4"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="338" mass="37215" checksum="81828D83A64456FB" modified="2005-12-06" version="1">MRVLVTGGSGYIGSNTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGSSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IH3</accession>
    <name>Q32IH3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0572</name>
        <name evidence="4" type="ordered locus">SDY_0699</name>
        <name evidence="5" type="ordered locus">SDY_1902</name>
        <name evidence="6" type="ordered locus">SDY_2283</name>
        <name evidence="7" type="ordered locus">SDY_3593</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60776">
        <property type="protein sequence ID" value="ABB60776"/>
        <property type="gene ID" value="SDY_0572"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60884">
        <property type="protein sequence ID" value="ABB60884"/>
        <property type="gene ID" value="SDY_0699"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62008">
        <property type="protein sequence ID" value="ABB62008"/>
        <property type="gene ID" value="SDY_1902"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62360">
        <property type="protein sequence ID" value="ABB62360"/>
        <property type="gene ID" value="SDY_2283"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63566">
        <property type="protein sequence ID" value="ABB63566"/>
        <property type="gene ID" value="SDY_3593"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0572"/>
    <dbReference type="KEGG" id="sdy:SDY_0699"/>
    <dbReference type="KEGG" id="sdy:SDY_1902"/>
    <dbReference type="KEGG" id="sdy:SDY_2283"/>
    <dbReference type="KEGG" id="sdy:SDY_3593"/>
    <dbReference type="HOGENOM" id="CLU_203300_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="60" mass="6950" checksum="D415CE1E8C9C31F6" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGDWPTLLVPVPMKPAGNYWHCLRHSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IQ5</accession>
    <name>Q32IQ5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nagD</name>
        <name evidence="2" type="ordered locus">SDY_0609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000153129.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402291.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IQ5"/>
    <dbReference type="SMR" id="Q32IQ5"/>
    <dbReference type="STRING" id="300267.SDY_0609"/>
    <dbReference type="EnsemblBacteria" id="ABB60802">
        <property type="protein sequence ID" value="ABB60802"/>
        <property type="gene ID" value="SDY_0609"/>
    </dbReference>
    <dbReference type="GeneID" id="67416288"/>
    <dbReference type="KEGG" id="sdy:SDY_0609"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.705"/>
    <dbReference type="HOGENOM" id="CLU_043473_1_1_6"/>
    <dbReference type="OMA" id="PPMHRET"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="250" mass="27163" checksum="CC256AE6FF58DEBA" modified="2005-12-06" version="1">MTIKNVICDIDGVLMHDNVAVPGAAEFLHGIMDKGLPLVLLTNYPSQTGQDLANRFATAGVDVPDSVFYTSAMATADFLRRQEGKKAYVVGEGALIHELYKAGFTITDVNPDFVIVGETRSYNWDMMHKAAYFVANGARFIATNPDTHGRGFYPACGALCAGIEKISGRKPFYVGKPSPWIIRAALNKMQAHSEETVIVGDNLRTDILAGFQAGLETILVLSGVSSLDDIDSMPFRPSWIYPSVAEIDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IR4</accession>
    <name>Q32IR4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybeX</name>
        <name evidence="5" type="ordered locus">SDY_0594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001278605.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402282.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IR4"/>
    <dbReference type="SMR" id="Q32IR4"/>
    <dbReference type="STRING" id="300267.SDY_0594"/>
    <dbReference type="EnsemblBacteria" id="ABB60793">
        <property type="protein sequence ID" value="ABB60793"/>
        <property type="gene ID" value="SDY_0594"/>
    </dbReference>
    <dbReference type="GeneID" id="67416302"/>
    <dbReference type="KEGG" id="sdy:SDY_0594"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.698"/>
    <dbReference type="HOGENOM" id="CLU_015237_3_0_6"/>
    <dbReference type="OMA" id="QMISIKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="292" mass="33298" checksum="7350B8B475485B32" modified="2005-12-06" version="1">MSDDNSHSSDTISNKKGFFSLLLSQLFHGEPKNRDELLALIRDSGQNDLIDEDTRDMLEGVMDIADQRVRDIMIPRSQMITLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILMAKDLLPFMRSDAEAFSMDKVLRQAVVVPESKRVDRMLKEFRSQRYHMAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIDFRQLSRHTWTVRALASIEDFNEAFGTHFSDEEVDTIGGLVMQAFGHLPARGETIDIDGYQFKVAMADSRRIIQVHVKIPDDSPQPKLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IR8</accession>
    <name>Q32IR8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_0284</name>
        <name evidence="5" type="ordered locus">SDY_0590</name>
        <name evidence="6" type="ordered locus">SDY_0715</name>
        <name evidence="7" type="ordered locus">SDY_0728</name>
        <name evidence="8" type="ordered locus">SDY_1123</name>
        <name evidence="9" type="ordered locus">SDY_1386</name>
        <name evidence="10" type="ordered locus">SDY_1672</name>
        <name evidence="11" type="ordered locus">SDY_2930</name>
        <name evidence="12" type="ordered locus">SDY_2960</name>
        <name evidence="13" type="ordered locus">SDY_3813</name>
        <name evidence="14" type="ordered locus">SDY_4089</name>
        <name evidence="15" type="ordered locus">SDY_4491</name>
        <name evidence="16" type="ordered locus">SDY_4609</name>
        <name evidence="17" type="ordered locus">SDY_P079</name>
    </gene>
    <organism evidence="5 18">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="17 18">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="5 18" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 18">Sd197</strain>
            <plasmid evidence="18">Plasmid pSD1_197</plasmid>
            <plasmid evidence="17">pSD1_197</plasmid>
            <plasmid evidence="17">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Sd197</strain>
            <plasmid evidence="17">pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401992.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402278.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402388.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402401.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402771.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403022.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403284.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404447.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404477.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405249.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405496.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405858.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405957.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406080.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0284"/>
    <dbReference type="EnsemblBacteria" id="ABB60503">
        <property type="protein sequence ID" value="ABB60503"/>
        <property type="gene ID" value="SDY_0284"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60789">
        <property type="protein sequence ID" value="ABB60789"/>
        <property type="gene ID" value="SDY_0590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60899">
        <property type="protein sequence ID" value="ABB60899"/>
        <property type="gene ID" value="SDY_0715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60912">
        <property type="protein sequence ID" value="ABB60912"/>
        <property type="gene ID" value="SDY_0728"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61280">
        <property type="protein sequence ID" value="ABB61280"/>
        <property type="gene ID" value="SDY_1123"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61531">
        <property type="protein sequence ID" value="ABB61531"/>
        <property type="gene ID" value="SDY_1386"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61793">
        <property type="protein sequence ID" value="ABB61793"/>
        <property type="gene ID" value="SDY_1672"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62956">
        <property type="protein sequence ID" value="ABB62956"/>
        <property type="gene ID" value="SDY_2930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62986">
        <property type="protein sequence ID" value="ABB62986"/>
        <property type="gene ID" value="SDY_2960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63758">
        <property type="protein sequence ID" value="ABB63758"/>
        <property type="gene ID" value="SDY_3813"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64005">
        <property type="protein sequence ID" value="ABB64005"/>
        <property type="gene ID" value="SDY_4089"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64367">
        <property type="protein sequence ID" value="ABB64367"/>
        <property type="gene ID" value="SDY_4491"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64466">
        <property type="protein sequence ID" value="ABB64466"/>
        <property type="gene ID" value="SDY_4609"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64592">
        <property type="protein sequence ID" value="ABB64592"/>
        <property type="gene ID" value="SDY_P079"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0284"/>
    <dbReference type="KEGG" id="sdy:SDY_0590"/>
    <dbReference type="KEGG" id="sdy:SDY_0715"/>
    <dbReference type="KEGG" id="sdy:SDY_0728"/>
    <dbReference type="KEGG" id="sdy:SDY_1123"/>
    <dbReference type="KEGG" id="sdy:SDY_1386"/>
    <dbReference type="KEGG" id="sdy:SDY_1672"/>
    <dbReference type="KEGG" id="sdy:SDY_2930"/>
    <dbReference type="KEGG" id="sdy:SDY_2960"/>
    <dbReference type="KEGG" id="sdy:SDY_3813"/>
    <dbReference type="KEGG" id="sdy:SDY_4089"/>
    <dbReference type="KEGG" id="sdy:SDY_4491"/>
    <dbReference type="KEGG" id="sdy:SDY_4609"/>
    <dbReference type="KEGG" id="sdy:SDY_P079"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1324"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="OMA" id="HNWVKAD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0614">Plasmid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB64005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB64367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB64466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB64592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11176" checksum="2FB3A770DA5F3605" modified="2005-12-06" version="1">MSRKTQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGPLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKATAYFAQESLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IS9</accession>
    <name>Q32IS9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000640132.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402267.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IS9"/>
    <dbReference type="STRING" id="300267.SDY_0578"/>
    <dbReference type="EnsemblBacteria" id="ABB60778">
        <property type="protein sequence ID" value="ABB60778"/>
        <property type="gene ID" value="SDY_0578"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0578"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.678"/>
    <dbReference type="HOGENOM" id="CLU_109748_0_0_6"/>
    <dbReference type="OMA" id="ICILRQR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010557">
        <property type="entry name" value="DUF1133"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06576">
        <property type="entry name" value="DUF1133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="184" mass="21049" checksum="1B0AF72694E4A3F4" modified="2005-12-06" version="1">MIYPTNTGKSGEHLRLTTLESVWIQGKLRMWGRWSYIGGGKTGNMFNQLLASKKLTKTAINEALRRMKKAGLDKPELEAFLRDMINGKQKSWLVHCTDAEALCIVRVISEVLAEHPGLICILRQRYEGSGMTKRKMAELLNDSHPEWCYRTCCSRVDVWLNLAEYMLYLPMRDAFSSGDLKTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IV4</accession>
    <name>Q32IV4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybeM</name>
        <name evidence="3" type="ordered locus">SDY_0548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IV4"/>
    <dbReference type="STRING" id="300267.SDY_0548"/>
    <dbReference type="EnsemblBacteria" id="ABB60753">
        <property type="protein sequence ID" value="ABB60753"/>
        <property type="gene ID" value="SDY_0548"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0548"/>
    <dbReference type="HOGENOM" id="CLU_030130_1_2_6"/>
    <dbReference type="OMA" id="MTCYDVR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="210" mass="22867" checksum="0087568503D1BD6A" modified="2005-12-06" version="1">MLVAAGQFAVTSVWEKNAEICASLMAQAAENDVSLFVLPEALLARDDHDADLSVKSAQLLEGEFLGRLRRESKRNMMTIILTIHVPSTPGRAWNMLVALQAGNIVARYAKLHLYDAFAIQESRHVDAGNEIAPLLEVEGMKVGLMTCYDLLFPELALAQALQGAEILVLPAAWVRGPLKEHHWSTLLAARALDTTCYMVAAGECGNKNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IX5</accession>
    <name>Q32IX5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,3-dihydroxybenzoate-AMP ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">entE</name>
        <name evidence="5" type="ordered locus">SDY_0525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000026832.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402221.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IX5"/>
    <dbReference type="STRING" id="300267.SDY_0525"/>
    <dbReference type="EnsemblBacteria" id="ABB60732">
        <property type="protein sequence ID" value="ABB60732"/>
        <property type="gene ID" value="SDY_0525"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0525"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.618"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_6"/>
    <dbReference type="OMA" id="PNIRFIR"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008668">
        <property type="term" value="F:(2,3-dihydroxybenzoyl)adenylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011963">
        <property type="entry name" value="DHB_AMP_lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02275">
        <property type="entry name" value="DHB_AMP_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="37"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="4">
        <location>
            <begin position="446"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="536" mass="59053" checksum="67E69C595D14E911" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J20</accession>
    <name>Q32J20_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminoacyl-histidine dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pepD</name>
        <name evidence="3" type="ordered locus">SDY_0480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001293005.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402176.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J20"/>
    <dbReference type="STRING" id="300267.SDY_0480"/>
    <dbReference type="MEROPS" id="M20.007"/>
    <dbReference type="EnsemblBacteria" id="ABB60687">
        <property type="protein sequence ID" value="ABB60687"/>
        <property type="gene ID" value="SDY_0480"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0480"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.565"/>
    <dbReference type="HOGENOM" id="CLU_028526_0_0_6"/>
    <dbReference type="OMA" id="KGGYPGW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03890">
        <property type="entry name" value="M20_pepD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001160">
        <property type="entry name" value="Peptidase_M20C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43501">
        <property type="entry name" value="PTHR43501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016599">
        <property type="entry name" value="Xaa-His_dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00934">
        <property type="entry name" value="XHISDIPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01893">
        <property type="entry name" value="aa-his-dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="209"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="485" mass="52931" checksum="685E61B6A43C5FB2" modified="2005-12-06" version="1">MSELSQLSPQPLWDIFAKICSIPHPSYHEEQLAEYIVGWAKEKGFHVERDQVGNILIRKPATAGMENRKPVVLQAHLDMVPQKNNDTVHDFTKDPIQPYIDGEWVKARGTTLGADNGIGMASALAVLADENVVHGPLEVLLTMTEEAGMDGAFGLQSNWLQADILINTDSEEEGEIYMGCAGGIDFTSNLHLDREAVPAGFETFKLTLKGLKGGHSGGEIHVGLGNANKLLVRFLAGHAEELDLRLIDFNGGTLRNAIPREAFATIAVAADKVDALKSLVNTYQEILKNELAEKEKNLALLLDSVANDKAALIAKSRDTFIRLLNATPNGVIRNSDVAKGVVETSLNVGVVTMTDNNVEIHCLIRSLIDSGKDYLVSMLDSLGKLAGAKTEAKGAYPGWQPDANSPVMHLVRETYQRLFNKTPNIQIIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIESVGHYWTLLTELLKEIPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J48</accession>
    <name>Q32J48_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inner membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybaN</name>
        <name evidence="3" type="ordered locus">SDY_0451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001188905.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402148.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J48"/>
    <dbReference type="STRING" id="300267.SDY_0451"/>
    <dbReference type="EnsemblBacteria" id="ABB60659">
        <property type="protein sequence ID" value="ABB60659"/>
        <property type="gene ID" value="SDY_0451"/>
    </dbReference>
    <dbReference type="GeneID" id="66671230"/>
    <dbReference type="KEGG" id="sdy:SDY_0451"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.534"/>
    <dbReference type="HOGENOM" id="CLU_113299_1_0_6"/>
    <dbReference type="OMA" id="SPRFHDW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007401">
        <property type="entry name" value="DUF454"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35813">
        <property type="entry name" value="PTHR35813"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04304">
        <property type="entry name" value="DUF454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016789">
        <property type="entry name" value="DUF454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14770" checksum="F12848BDD9330764" modified="2005-12-06" version="1">MQRIILIIIGWLAVVLGTLGVVLPVLPTTPFILLAAWCFARSSPRFHAWLLYRSWFGSYLRFWQKHHAMPRGVKPRAILLILLTFAISLWFVQMPWVRIMLLVILACLLFYMWRIPVIDEKQEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J64</accession>
    <name>Q32J64_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amino acid/amine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ybaT</name>
        <name evidence="6" type="ordered locus">SDY_0432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000982163.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402132.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J64"/>
    <dbReference type="STRING" id="300267.SDY_0432"/>
    <dbReference type="EnsemblBacteria" id="ABB60643">
        <property type="protein sequence ID" value="ABB60643"/>
        <property type="gene ID" value="SDY_0432"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0432"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.512"/>
    <dbReference type="HOGENOM" id="CLU_007946_15_2_6"/>
    <dbReference type="OMA" id="KPFWPSC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="430" mass="45643" checksum="0AC97CC07C254F3F" modified="2005-12-06" version="1">MMNTEGNNGNKPLGLWNVVSIGIGAMVGAGIFALLGQAALLMEASTWVAFAFGGIVAMFSGYAYARLGASYPSNGGIIDFFRRGLGNGVFSLALSLLYLLTLAVSIAMVARAFGAYAVQFLHEGSQEEHLILLYALGIIAVMTLFNSLSNHAVGRLEVILVGIKMMILLLLIIAGVWSLQPAHISVSAPPSSGAFFSCIGITFLAYAGFGMMANAADKVKDPKVIMPRAFLVAIGVTTLLYISLALVLLSDVSALELEKYADTAVAQAASPLLGHVGYVIVVIGALLATASAINANLFAVFNIMDNMGSERELPKLMNKSLWRQSTWGNIIVVVLIMLMTAALNLGSLASVASATFLICYLAVFVVAIRLRHDIHASLPILIVGTLVMLLVIVGFIYSLWSQGSRALIWIIGAILLSLIVAMVMKRNKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J81</accession>
    <name>Q32J81_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional regulator CueR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Copper efflux regulator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Copper export regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybbI</name>
        <name evidence="7" type="ordered locus">SDY_0415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001026754.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402115.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J81"/>
    <dbReference type="STRING" id="300267.SDY_0415"/>
    <dbReference type="EnsemblBacteria" id="ABB60626">
        <property type="protein sequence ID" value="ABB60626"/>
        <property type="gene ID" value="SDY_0415"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0415"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.494"/>
    <dbReference type="HOGENOM" id="CLU_060077_2_0_6"/>
    <dbReference type="OMA" id="FNDPERH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01108">
        <property type="entry name" value="HTH_CueR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011789">
        <property type="entry name" value="CueR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02044">
        <property type="entry name" value="CueR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="15250" checksum="ADBED8F9E3140862" modified="2005-12-06" version="1">MNISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLLRQARQVGFNLEESGELVNLFNDPQRHSADVKRRTLEKVAEIERHIEELQSMRNQLLALANACPGDDSSDCPIIENLSGCCHHRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JF1</accession>
    <name>Q32JF1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS4 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020581.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402045.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JF1"/>
    <dbReference type="STRING" id="300267.SDY_0340"/>
    <dbReference type="EnsemblBacteria" id="ABB60556">
        <property type="protein sequence ID" value="ABB60556"/>
        <property type="gene ID" value="SDY_0340"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0340"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.395"/>
    <dbReference type="HOGENOM" id="CLU_028400_1_1_6"/>
    <dbReference type="OMA" id="QIRNTRM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024473">
        <property type="entry name" value="Transposases_IS4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13006">
        <property type="entry name" value="Nterm_IS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nterm_IS4" evidence="2">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="448" mass="51073" checksum="7F02A230EC1E01D9" modified="2005-12-06" version="1">MFPDFFMHIGQALDLVSCYDSLRNPLTSLGDYLDPELISRCLAESGTVTLRKRRLPLEMMVWCIVGMVLERKEPLHQIVNRLDIMLPGNRPFVAPSAVIQARQLLGSEAVRRVFTKTAQLWHNATPHPHWCGLTLLAIDGVFWRTPDTPENNAAFPRQTHAGNPALYPQVKMVCQMELTSHLLTAAAFGTMKNSENELAEQLIEQTGDNTLTLMDKGYYSLGLLNAWSLAGEHRHWMIPLRKGAQYEEIRKLGKGDHLVKLKTSPQARKKWPGLGNEVTARLLTVTRKGKVCHLLTSMTDAMRFPGGEMADLYSHRWEIELGYREIKQTMQLSRLTLRSKKPELVEQELWGVLLAYNLVRYQMIKMAEHLKGYWPNQLSFSESCGMVMRMLMTLQGASPGRIPELMRDLASMGQLVKLPTRRERAFPRVVKERPWKYPTAPKKSQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JH4</accession>
    <name>Q32JH4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402022.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JH4"/>
    <dbReference type="STRING" id="300267.SDY_0314"/>
    <dbReference type="EnsemblBacteria" id="ABB60533">
        <property type="protein sequence ID" value="ABB60533"/>
        <property type="gene ID" value="SDY_0314"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0314"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.361"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15342" checksum="6750AD8C219FACFB" modified="2005-12-06" version="1">MALICELDEQWSFVGSKAWQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMSTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVESHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JN0</accession>
    <name>Q32JN0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yafM</name>
        <name evidence="2" type="ordered locus">SDY_0254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401966.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JN0"/>
    <dbReference type="STRING" id="300267.SDY_0254"/>
    <dbReference type="EnsemblBacteria" id="ABB60477">
        <property type="protein sequence ID" value="ABB60477"/>
        <property type="gene ID" value="SDY_0254"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0254"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.286"/>
    <dbReference type="HOGENOM" id="CLU_068226_6_0_6"/>
    <dbReference type="OMA" id="DHIHALW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="13657" checksum="A4640E75EC9BDC49" modified="2005-12-06" version="1">MSEYRRYYLKGGSWFFTVNLRNRRSQLLTTQYQTLRNAIIKVKRARPFEINAWVVLPEHMHCIWTLPESDDDFSSRWREIKKQFTHACGLKNIWQPRFWEHAIRNTVMPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JW3</accession>
    <name>Q32JW3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-Q tRNA(Asp) synthetase</fullName>
            <shortName evidence="5">Glu-Q-RSs</shortName>
            <ecNumber evidence="5">6.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yadB</name>
        <name evidence="5" type="synonym">gluQ</name>
        <name evidence="8" type="ordered locus">SDY_0160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JW3"/>
    <dbReference type="STRING" id="300267.SDY_0160"/>
    <dbReference type="EnsemblBacteria" id="ABB60394">
        <property type="protein sequence ID" value="ABB60394"/>
        <property type="gene ID" value="SDY_0160"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0160"/>
    <dbReference type="HOGENOM" id="CLU_015768_0_1_6"/>
    <dbReference type="OMA" id="WLLRMED"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01428">
        <property type="entry name" value="Glu_Q_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022380">
        <property type="entry name" value="Glu-Q_tRNA(Asp)_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03838">
        <property type="entry name" value="queuosine_YadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="7">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glutamate binding" evidence="5">
        <location>
            <begin position="19"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="5">
        <location>
            <begin position="238"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="308" mass="34877" checksum="0FA8FCC7D63664CF" modified="2005-12-06" version="1">MLPPYFLFEEMTDTHYIGRFAPSPSGELHFGSLIAALGSYLQARARQGRWLVRIEDIDPPREVPSAAETILRQLEHYGLHWDGDVLWQSQRHHAYREALAWLHEQGLSYYCTCTRARIQSIGGIYDGHCRELHHGPGNAAVRIRQQHPVTQFTDLLRGIIHADEKLAREDFIIHRRDGLFAYNLAVVVDDHFQGVSEIVRGTDLIEPTVRQISLYQLFGWKVPDYIHLPLALNPQGAKLSKQNHAPALPKGDPRPVLIAALQFLGQQAEAHWQDFSVEQILQSAVKNWTLTAEPESAIVNSTFSNASC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K21</accession>
    <name>LEU3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="1">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuB</name>
        <name type="ordered locus">SDY_0100</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60336" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60336.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000042324.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401825.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K21"/>
    <dbReference type="SMR" id="Q32K21"/>
    <dbReference type="STRING" id="300267.SDY_0100"/>
    <dbReference type="EnsemblBacteria" id="ABB60336">
        <property type="protein sequence ID" value="ABB60336"/>
        <property type="gene ID" value="SDY_0100"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0100"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.119"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_6"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000083746" description="3-isopropylmalate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="363" mass="39572" checksum="F7AAF96E5E94F62F" modified="2006-01-10" version="2">MSKNYHIAALPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAASAIERAINRALEEGIRTRDLARGAAAVSTDEMGDIIARYVAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q327D9</accession>
    <name>Q327D9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OspD3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ospD3</name>
        <name evidence="2" type="ordered locus">SDY_P056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406057.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327D9"/>
    <dbReference type="EnsemblBacteria" id="ABB64569">
        <property type="protein sequence ID" value="ABB64569"/>
        <property type="gene ID" value="SDY_P056"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P056"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5601"/>
    <dbReference type="HOGENOM" id="CLU_495867_0_0_6"/>
    <dbReference type="OMA" id="IRWPDNL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012927">
        <property type="entry name" value="Toxin_15_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07906">
        <property type="entry name" value="Toxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toxin_15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="549" mass="61314" checksum="A7A890B0626ABC9D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q327L2</accession>
    <name>DEOD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Purine nucleoside phosphorylase DeoD-type</fullName>
            <shortName evidence="2">PNP</shortName>
            <ecNumber evidence="2">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">deoD</name>
        <name type="ordered locus">SDY_4644</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer; trimer of homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000224880.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405984.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327L2"/>
    <dbReference type="SMR" id="Q327L2"/>
    <dbReference type="STRING" id="300267.SDY_4644"/>
    <dbReference type="PRIDE" id="Q327L2"/>
    <dbReference type="EnsemblBacteria" id="ABB64493">
        <property type="protein sequence ID" value="ABB64493"/>
        <property type="gene ID" value="SDY_4644"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4644"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5505"/>
    <dbReference type="HOGENOM" id="CLU_068457_2_0_6"/>
    <dbReference type="OMA" id="PQCLLCG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09006">
        <property type="entry name" value="PNP_EcPNPI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01627">
        <property type="entry name" value="Pur_nucleosid_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004402">
        <property type="entry name" value="DeoD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF2">
        <property type="entry name" value="PTHR43691:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00107">
        <property type="entry name" value="deoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000063163" description="Purine nucleoside phosphorylase DeoD-type">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="2">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P50389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01627"/>
        </source>
    </evidence>
    <sequence length="239" mass="25935" checksum="FA507ADA44F87781" modified="2005-12-06" version="1">MATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGVDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGNKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q327U6</accession>
    <name>UBIC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate pyruvate-lyase</fullName>
            <shortName evidence="1">CL</shortName>
            <shortName evidence="1">CPL</shortName>
            <ecNumber evidence="1">4.1.3.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiC</name>
        <name type="ordered locus">SDY_4535</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = 4-hydroxybenzoate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:16505"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="EC" id="4.1.3.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiC family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB64409" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.40" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64409.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001297295.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405900.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327U6"/>
    <dbReference type="SMR" id="Q327U6"/>
    <dbReference type="STRING" id="300267.SDY_4535"/>
    <dbReference type="EnsemblBacteria" id="ABB64409">
        <property type="protein sequence ID" value="ABB64409"/>
        <property type="gene ID" value="SDY_4535"/>
    </dbReference>
    <dbReference type="GeneID" id="66672046"/>
    <dbReference type="KEGG" id="sdy:SDY_4535"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5359"/>
    <dbReference type="HOGENOM" id="CLU_096824_1_0_6"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008813">
        <property type="term" value="F:chorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042866">
        <property type="term" value="P:pyruvate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01632">
        <property type="entry name" value="UbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007440">
        <property type="entry name" value="Chorismate--pyruvate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38683">
        <property type="entry name" value="PTHR38683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04345">
        <property type="entry name" value="Chor_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="chain" id="PRO_0000240574" description="Chorismate pyruvate-lyase">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="165" mass="18835" checksum="26EA4355B962029F" modified="2006-06-27" version="2">MSHPALTQLRALRYFKEIPALEPQLLDWLLLEDSMTKRFEQQGKTVSVTMIREGFVEQNEIPEELPLLPKESRYWLREILLCADGEPWLAGRTVVPVSTLSGPELALQKLGKTPLGRYLFTSSTLTRDFIEIGRDAGLWGRRSRLRLSGKPLLLTELFLPASPLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q327W0</accession>
    <name>ALR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine racemase</fullName>
            <ecNumber evidence="1">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">alr</name>
        <name type="ordered locus">SDY_4521</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001147331.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405886.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327W0"/>
    <dbReference type="SMR" id="Q327W0"/>
    <dbReference type="STRING" id="300267.SDY_4521"/>
    <dbReference type="EnsemblBacteria" id="ABB64395">
        <property type="protein sequence ID" value="ABB64395"/>
        <property type="gene ID" value="SDY_4521"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4521"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5344"/>
    <dbReference type="HOGENOM" id="CLU_028393_1_0_6"/>
    <dbReference type="OMA" id="WEILCGF"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000066038" description="Alanine racemase">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="1">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <sequence length="359" mass="39165" checksum="1CB591F0DE43B948" modified="2005-12-06" version="1">MQAATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHGLLETARTLPDADAFGVARLEEALRLRAGGITKPVLLLEGFFDARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVWMKLDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFARADEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLWPQSHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSSLIAVREHKVGEPVGYGGTWISERDTRLGVVAMGYGDGYPRAAPSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGDPVILWGEGLPVERIAEMTKVSAYELIARLTSRVAMKYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q328H5</accession>
    <name>Q328H5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Outer membrane lipoprotein Blc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">blc</name>
        <name evidence="5" type="ordered locus">SDY_4393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001238386.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405771.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328H5"/>
    <dbReference type="STRING" id="300267.SDY_4393"/>
    <dbReference type="EnsemblBacteria" id="ABB64280">
        <property type="protein sequence ID" value="ABB64280"/>
        <property type="gene ID" value="SDY_4393"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4393"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5189"/>
    <dbReference type="HOGENOM" id="CLU_068449_3_0_6"/>
    <dbReference type="OMA" id="YSCTTIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002446">
        <property type="entry name" value="Lipocalin_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01171">
        <property type="entry name" value="BCTLIPOCALIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013436139" description="Outer membrane lipoprotein Blc" evidence="2">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocln_cytosolic_FA-bd_dom" evidence="4">
        <location>
            <begin position="34"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="3">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="3">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036893-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="177" mass="19941" checksum="6F8A92815B1058F8" modified="2005-12-06" version="1">MRLLPLVAAATVAFLVVACSSPTPPRGVTVVNNFDAKRYLGTWYEIARFDHRFERGLKKVTATYSLRDDGGLNVINKGYNPDREMWQQSEGKAYFTGASTRAALKVSFFGPFYGGYNVIALDREYRHALVCGPDRDYLWILSRTPTISDEVKQEMLAVATREGFDVSKFIWVQQPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q328S0</accession>
    <name>Q328S0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipopolysaccharide export system permease protein LptF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">yjgP</name>
        <name evidence="14" type="ordered locus">SDY_4285</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LptF/LptG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000584106.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405676.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328S0"/>
    <dbReference type="STRING" id="300267.SDY_4285"/>
    <dbReference type="EnsemblBacteria" id="ABB64185">
        <property type="protein sequence ID" value="ABB64185"/>
        <property type="gene ID" value="SDY_4285"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4285"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5052"/>
    <dbReference type="HOGENOM" id="CLU_028799_0_2_6"/>
    <dbReference type="OMA" id="ELQWRIA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030922">
        <property type="entry name" value="LptF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04407">
        <property type="entry name" value="LptF_YjgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB64185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="366" mass="40340" checksum="8DE164A85B0BFFEB" modified="2005-12-06" version="1">MIIIRYLVRETLKSQLAILFILLLIFFCQKLVRILGAAVDGDIPANLVLSLLGLGVPEMAQLILPLSLFLGLLMTLGKLYTESEITVMHACGLSKAVLVKAAIILAVFTAIVAAVNVMWAGPWSSRHQDEVLAEAKANPGMAALAQGQFQQATNGSSVLFIESVDGSDFKDVFLAQIRPKGNARPSVVVADSGHLTQLRDGSQVVTLNQGTRFEGTALLRDFRITDFQDYQAIIGHQAVALDPNDTDQMDMRTLWNTDTDRARAELNWRITLVFTVFMMALMVVPLSVVNPRQGRVLSMLPAMLLYLLFFLIQTSLKSNGGKGKLDPTLWMWTVNLIYLALAIVLNLWDTVPVRRLRASFSRKGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q328U3</accession>
    <name>Q328U3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="5">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">mgtA</name>
        <name evidence="18" type="ordered locus">SDY_4261</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000471887.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405653.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328U3"/>
    <dbReference type="STRING" id="300267.SDY_4261"/>
    <dbReference type="EnsemblBacteria" id="ABB64162">
        <property type="protein sequence ID" value="ABB64162"/>
        <property type="gene ID" value="SDY_4261"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4261"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5023"/>
    <dbReference type="HOGENOM" id="CLU_002360_6_3_6"/>
    <dbReference type="OMA" id="GVHRMAK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02077">
        <property type="entry name" value="P-type_ATPase_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="869"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="17">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB64162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="898" mass="99497" checksum="060CFA9A690C13A8" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q329E3</accession>
    <name>Q329E3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329E3"/>
    <dbReference type="EnsemblBacteria" id="ABB64062">
        <property type="protein sequence ID" value="ABB64062"/>
        <property type="gene ID" value="SDY_4153"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4153"/>
    <dbReference type="HOGENOM" id="CLU_1271556_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="217" mass="24118" checksum="6665102A079E1638" modified="2005-12-06" version="1">MLIPKSLTIFTLCQALKIMVIVPGWRQLEENEYTVIEQTGGKSFNVFQVGAGKNNIKEILGNTSYSGVAVATIIKSLSEKAAALETHSADTVLRKKLVNSIVMMNTDCSYEMPADIVSNTYDLLNLRIQKDEGHLPVQEKIDITEDYLHSMTMDAHRCIKEQTKPSGAAKITCCGVELSKDILKIFAEKIETIEKDPNYSQKTPEQLVAQVCFKDDG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q329F0</accession>
    <name>ADEC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine deaminase</fullName>
            <shortName evidence="1">Adenase</shortName>
            <shortName evidence="1">Adenine aminase</shortName>
            <ecNumber evidence="1">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ade</name>
        <name type="ordered locus">SDY_4146</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001065727.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405546.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329F0"/>
    <dbReference type="SMR" id="Q329F0"/>
    <dbReference type="STRING" id="300267.SDY_4146"/>
    <dbReference type="EnsemblBacteria" id="ABB64055">
        <property type="protein sequence ID" value="ABB64055"/>
        <property type="gene ID" value="SDY_4146"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4146"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4873"/>
    <dbReference type="HOGENOM" id="CLU_027935_0_0_6"/>
    <dbReference type="OMA" id="TDHECFT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01295">
        <property type="entry name" value="AdeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01178">
        <property type="entry name" value="ade"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000296732" description="Adenine deaminase">
        <location>
            <begin position="1"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01518"/>
        </source>
    </evidence>
    <sequence length="584" mass="63398" checksum="DDAF1B06670994AA" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q329H2</accession>
    <name>Q329H2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulator, phn operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phnO</name>
        <name evidence="2" type="ordered locus">SDY_4123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001110479.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405524.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329H2"/>
    <dbReference type="STRING" id="300267.SDY_4123"/>
    <dbReference type="EnsemblBacteria" id="ABB64033">
        <property type="protein sequence ID" value="ABB64033"/>
        <property type="gene ID" value="SDY_4123"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4123"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4847"/>
    <dbReference type="HOGENOM" id="CLU_013985_34_6_6"/>
    <dbReference type="OMA" id="ASHVGFK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="144" mass="16527" checksum="F90A665E5A3012E5" modified="2005-12-06" version="1">MPACELRPATQYDTDAVYALICELKQAEFDHHAFLVGFNANLRDPNMRYHLALLDGEVVGMIGLHLQFHLHHVNWIGEIQELVVMPQARGLNVGSKLLAWAEEEARQAGAEMTELSTNVKRHDAHRFYLREGYEQSHFRFTKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q329I1</accession>
    <name>Q329I1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane channel protein component of Pn transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">phnE</name>
        <name evidence="8" type="ordered locus">SDY_4113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405515.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329I1"/>
    <dbReference type="STRING" id="300267.SDY_4113"/>
    <dbReference type="EnsemblBacteria" id="ABB64024">
        <property type="protein sequence ID" value="ABB64024"/>
        <property type="gene ID" value="SDY_4113"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4113"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4837"/>
    <dbReference type="HOGENOM" id="CLU_064254_0_2_6"/>
    <dbReference type="OMA" id="RFAIIGR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="86"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="276" mass="30324" checksum="EE01BF123AF1C406" modified="2005-12-06" version="1">MPDAVQAPYPAYRPEPNMQTITIAPPKRSWFSLLSWAVVLAVLVVSWQGAEMAPLTLIKDGGNMATFAADFFPPDFSQWQDYLTEMLVTLQIAVWGTALAVVLSIPFGLMSAENLVPWWVYQPVRRLMDACRAINEMVFAMLFVVAVGLGPFAGVLALFIHTTGVLSKLLSEAVEAIEPGPVEGIRATGANKLEEILYGVLPQVMPLLISYSLYRFESNVRSATVVGMVGAGGIGVTLWEAIRGFQFQQTCALMVLIIVTVSLLDFLSQRLRKHFI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q329L3</accession>
    <name>RNPH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease PH</fullName>
            <shortName evidence="1">RNase PH</shortName>
            <ecNumber evidence="1">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rph</name>
        <name type="ordered locus">SDY_4074</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001247084.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405483.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329L3"/>
    <dbReference type="SMR" id="Q329L3"/>
    <dbReference type="STRING" id="300267.SDY_4074"/>
    <dbReference type="EnsemblBacteria" id="ABB63992">
        <property type="protein sequence ID" value="ABB63992"/>
        <property type="gene ID" value="SDY_4074"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4074"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4793"/>
    <dbReference type="HOGENOM" id="CLU_050858_0_0_6"/>
    <dbReference type="OMA" id="KGKGQGW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000024890" description="Ribonuclease PH">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <sequence length="238" mass="25344" checksum="D46A194537B9911B" modified="2005-12-06" version="1">MRPAGRSNNQVRPVTLTRNYTKHAEGSVLVEFGDTKVLCTASIEEGVPRFLKGQGQGWITAEYGMLPRSTHTRNAREAAKGKQGGRTMEIQRLIARALRAAVDLKALGEFTITLDCDVLQADGGTRTASITGACMALADALQKLVENGKLKTNPMKGMVAAVSVGIVNGEAVCDLEYVEDSAAETDMNVVMTEDGRIIEVQGTAEGEPFTHEELLTLLALARGGIESIVATQKAALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q329L6</accession>
    <name>Q329L6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoid occlusion factor SlmA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ttk</name>
        <name evidence="4" type="synonym">slmA</name>
        <name evidence="7" type="ordered locus">SDY_4071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoid occlusion factor SlmA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329L6"/>
    <dbReference type="STRING" id="300267.SDY_4071"/>
    <dbReference type="EnsemblBacteria" id="ABB63989">
        <property type="protein sequence ID" value="ABB63989"/>
        <property type="gene ID" value="SDY_4071"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4071"/>
    <dbReference type="HOGENOM" id="CLU_069356_5_0_6"/>
    <dbReference type="OMA" id="IEQTVFG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010974">
        <property type="term" value="P:negative regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01839">
        <property type="entry name" value="NO_factor_SlmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023769">
        <property type="entry name" value="NO_SlmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="212" mass="24318" checksum="3790D96615489E38" modified="2005-12-06" version="1">MPPGKCLFSGVFCNMAEKQTAKRNRREEILQSLALMLESSDGSQRITTAKLAASVGVSEAALYRHFPSKTRMFDSLIEFIEDSLITRINLILKDEKDTTARLRLIVLLLLGFGERNPGLTRILTGHALMFEQDRLQGRINQLFERIEAQLRQVLREKRMREGEGYTTDETLLASQILAFCEGMLSRFVRSEFKYRPTDDFDARWPLIAAQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q329R4</accession>
    <name>Q329R4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pstC</name>
        <name evidence="12" type="ordered locus">SDY_4023</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000741611.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405432.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329R4"/>
    <dbReference type="STRING" id="300267.SDY_4023"/>
    <dbReference type="EnsemblBacteria" id="ABB63941">
        <property type="protein sequence ID" value="ABB63941"/>
        <property type="gene ID" value="SDY_4023"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4023"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4737"/>
    <dbReference type="HOGENOM" id="CLU_033621_1_3_6"/>
    <dbReference type="OMA" id="VIRMSVL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="89"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="333" mass="35637" checksum="1CC22E3CBCFE8CE7" modified="2005-12-06" version="1">MAATKPAFNLPGKKGDIIFSVLVKLAALIVLLMLGGIIVSLIISSWPSIQKFGLAFLWTKEWDAPNDIYGALVPIYGTLVPIYGTLVPIYGTLVTSFIALLIAVPVSFGIALFLTELAPGWLKRPLGIAIELLAAIPSIVYGMWGLFIFAPLFAVYFQEPVGNIMSNIPIVGALFSGPAFGIGILAAGVILAIMIIPYIAAVMRDVFEQTPVMMKESAYGIGCTIWEVIWRIVLPFTKNGVIGGIMLGLGRALGETMAVTFIIGNTYQLDSASLYMPGNSITSALANEFAEAESGLHVAALMELGLILFVITFIVLAASKFMIMRLAKNEGAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q329T4</accession>
    <name>VIAA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein ViaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">VWA domain protein interacting with AAA ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">viaA</name>
        <name type="ordered locus">SDY_4003</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Possible formation of a ternary complex RavA-ViaA-CadA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ViaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000956654.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405412.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329T4"/>
    <dbReference type="SMR" id="Q329T4"/>
    <dbReference type="STRING" id="300267.SDY_4003"/>
    <dbReference type="EnsemblBacteria" id="ABB63921">
        <property type="protein sequence ID" value="ABB63921"/>
        <property type="gene ID" value="SDY_4003"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4003"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4715"/>
    <dbReference type="HOGENOM" id="CLU_022130_0_0_6"/>
    <dbReference type="OMA" id="GIHQSDD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01626">
        <property type="entry name" value="ViaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023481">
        <property type="entry name" value="Uncharacterised_ViaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000196591" description="Protein ViaA">
        <location>
            <begin position="1"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01626"/>
        </source>
    </evidence>
    <sequence length="483" mass="55806" checksum="504EDA785EA803E0" modified="2005-12-06" version="1">MLTLDTLNVMLAVSEEGLIEEMIIALLASPQLAVFFEKFPRLKAAITDDVPRWREALRSRLTDARVPPELTEEVMCYQQSQLLSTPQFIVQLPQILDLLHRLNSPWAEQARQLVDANSSITSALHTLFLQRWRLSLIVQATTLNQQLLEEEREQLLSEVQERMTLSGQLEPILADNNTGAGRLWDMSAGQLKRGDYQLIVKYGEFLNEQPELKRLAEQLGRSREAKSIPRNDAQMETFRTMVREPATVPEQVDGLQQSDDILRLLPPELATLGITELEYEFYRRLVEKQLLTYRLHGESLREKVIERPVVHKDYDEQPRGPFIVCVDTSGSMGGFNEQCAKAFCLALMRIALAENRRCYIMLFSTEIVRYELSGPQGIEQAIRFLNQQFRGGTDLASCFRAIMERLQSREWFDADAVVISDFIAQRLPDDVTSKVKELQRVHQHRFHAVAMSAHGKPGIMRIFDHIWRFDTGMRSRLLRRWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q329U7</accession>
    <name>Q329U7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvG</name>
        <name evidence="12" type="ordered locus">SDY_3980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001012642.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405399.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329U7"/>
    <dbReference type="STRING" id="300267.SDY_3980"/>
    <dbReference type="EnsemblBacteria" id="ABB63908">
        <property type="protein sequence ID" value="ABB63908"/>
        <property type="gene ID" value="SDY_3980"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3980"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4693"/>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_6"/>
    <dbReference type="OMA" id="FQEWPQV"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="186"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="374"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="548" mass="59251" checksum="1247D704AEF447AC" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q329U9</accession>
    <name>Q329U9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 19">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="19">BCAT</shortName>
            <ecNumber evidence="10 19">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">ilvE</name>
        <name evidence="20" type="ordered locus">SDY_3978</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 19">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 19">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 19">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 19">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 19">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 17">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="10 19"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000208520.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405397.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329U9"/>
    <dbReference type="SMR" id="Q329U9"/>
    <dbReference type="STRING" id="300267.SDY_3978"/>
    <dbReference type="EnsemblBacteria" id="ABB63906">
        <property type="protein sequence ID" value="ABB63906"/>
        <property type="gene ID" value="SDY_3978"/>
    </dbReference>
    <dbReference type="GeneID" id="60902519"/>
    <dbReference type="KEGG" id="sdy:SDY_3978"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4691"/>
    <dbReference type="HOGENOM" id="CLU_020844_3_1_6"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 19 20" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="16 19" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 19 20" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00013053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00018179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ABB63906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="309" mass="34094" checksum="E8A2B953168CD09D" modified="2005-12-06" version="1">MTTKKADYIWFNGEMVRWEDAKVHVMSHALHYGTSVFEGIRCYDSHKGPVVFRHREHMQRLHDSAKIYRFPVSQSIDELMEACRDVIRKNNLTSAYIRPLIFVGDVGMGVNPPAGYSTDVIIAAFPWGAYLGAEALEQGIDAMVSSWNRAAPNTIPTAAKAGGNYLSSLLVGSEARRHGYQEGIALDVNGYISEGAGENLFEVKDGVLFTPPFTSSALPGITRDAIIKLAKELGIEVREQVLSRESLYLADEVFMSGTAAEITPVRSVDGIQVGEGRCGPVTKRIQQAFFGLFTGETEDKWGWLDQVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q329V4</accession>
    <name>Q329V4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppiC</name>
        <name evidence="3" type="ordered locus">SDY_3973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001140251.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405392.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329V4"/>
    <dbReference type="SMR" id="Q329V4"/>
    <dbReference type="STRING" id="300267.SDY_3973"/>
    <dbReference type="EnsemblBacteria" id="ABB63901">
        <property type="protein sequence ID" value="ABB63901"/>
        <property type="gene ID" value="SDY_3973"/>
    </dbReference>
    <dbReference type="GeneID" id="66672321"/>
    <dbReference type="KEGG" id="sdy:SDY_3973"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4686"/>
    <dbReference type="HOGENOM" id="CLU_090028_6_1_6"/>
    <dbReference type="OMA" id="GPVRTQF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="93" mass="10232" checksum="678A1BF2CBEA969B" modified="2005-12-06" version="1">MAKTAAALHILVKEEKLALDLLEQIKNGADFGKLAKKHSICPSGKRGGDLGEFRQGQMVPAFDKVVFSCPVLEPTGPLHTQFGYHIIKVLYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q329W9</accession>
    <name>Q329W9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-amino-4,6-dideoxygalactose transaminase</fullName>
            <ecNumber evidence="2">2.6.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">wecE</name>
        <name evidence="6" type="ordered locus">SDY_3957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D-galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D-Glc4O) and L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:10368"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:68492"/>
            <dbReference type="EC" id="2.6.1.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.59" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000612058.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405377.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329W9"/>
    <dbReference type="STRING" id="300267.SDY_3957"/>
    <dbReference type="EnsemblBacteria" id="ABB63886">
        <property type="protein sequence ID" value="ABB63886"/>
        <property type="gene ID" value="SDY_3957"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3957"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4668"/>
    <dbReference type="HOGENOM" id="CLU_033332_0_2_6"/>
    <dbReference type="OMA" id="CQHNAHM"/>
    <dbReference type="UniPathway" id="UPA00566"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019180">
        <property type="term" value="F:dTDP-4-amino-4,6-dideoxygalactose transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009246">
        <property type="term" value="P:enterobacterial common antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02026">
        <property type="entry name" value="WecE_RffA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032894">
        <property type="entry name" value="WecE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012749">
        <property type="entry name" value="WecE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02379">
        <property type="entry name" value="ECA_wecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="376" mass="41962" checksum="229A5D71A5B4E02C" modified="2005-12-06" version="1">MIPFNAPPVVGTELDYMQSAMGSGKLCGDGGFTRRCQQWLEQRFGSAKVLLTPSCTASLEMAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDVRPDTMNIDETLIEAAITDKTRVIVPVHYAGVACEMDTIMALAKKHNLFVVEDAAQGVMSTYKGRALGTIGHIGCFSFHETKNYTAGGEGGATLINDKALIERAEIIREKGTNRSQFFRGQVDKYTWRDIGSSYLMSDLQAAYLWVQLEAADRINQQRLALWQNYYDALAPLAKAGRIELPSIPDGCLQNAHMFYIKLRDIDDRSALINFLKEAEIMAVFHYIPLHGCPAGERFGEFHGEDRYTTKESERLLRLPLFYNLSPVNQRTVIATLLNYFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Y7</accession>
    <name>XERC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xerC</name>
        <name type="ordered locus">SDY_3934</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges the top DNA strands.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">FtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000130686.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405359.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Y7"/>
    <dbReference type="SMR" id="Q329Y7"/>
    <dbReference type="STRING" id="300267.SDY_3934"/>
    <dbReference type="EnsemblBacteria" id="ABB63868">
        <property type="protein sequence ID" value="ABB63868"/>
        <property type="gene ID" value="SDY_3934"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3934"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4645"/>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_6"/>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011931">
        <property type="entry name" value="Recomb_XerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02224">
        <property type="entry name" value="recomb_XerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0229">DNA integration</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000070040" description="Tyrosine recombinase XerC">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Core-binding (CB)" evidence="3">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="1">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <sequence length="298" mass="33810" checksum="18087E6943A9B182" modified="2005-12-06" version="1">MTDLHTDVERYLRYLSVERQLSPITLLNYQRQLEAIINFASENGLQSWQQCDAAMVRNFAVRSRRKGLGAASLALRLSALRSFFDWLVSQNELKANPAKGVSAPKAPRHLPKNIDVDDMNRLLDIDINDPLAVRDRAMLEVMYGAGLRLSELVGLDIKHLDLESGEVWVMGKGSKERRLPIGRNAVAWIEHWLDLRDLFGSEDDALFLSKLGKRISARNVQKRFAEWGIKQGLNNHVHPHKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A30</accession>
    <name>Q32A30_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiol:disulfide interchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dsbA</name>
        <name evidence="10" type="ordered locus">SDY_3885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family. DsbA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000725348.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405316.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A30"/>
    <dbReference type="STRING" id="300267.SDY_3885"/>
    <dbReference type="EnsemblBacteria" id="ABB63825">
        <property type="protein sequence ID" value="ABB63825"/>
        <property type="gene ID" value="SDY_3885"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3885"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4598"/>
    <dbReference type="HOGENOM" id="CLU_088255_3_0_6"/>
    <dbReference type="OMA" id="NAIHKQK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03019">
        <property type="entry name" value="DsbA_DsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023205">
        <property type="entry name" value="DsbA/DsbL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001488">
        <property type="entry name" value="Tdi_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220969" description="Thiol:disulfide interchange protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="6"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="7">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001488-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="208" mass="23071" checksum="1EB27E87612AEAB5" modified="2005-12-06" version="1">MKKIWLALAGLVLAFSASAAQYEDGKQYTTLEKPVAGAPQVLEFFSFFCPHCYQFEEVLHISDNVKKKLPEGVKMTKYHVNLMGGDLGKDLTQAWAVAMALGVEDKVTVPLFEGVQKTQTIRSASDIRDVFINAGIKGEEYDAAWNSFVVKSLVAQQEKAAADVQLRGVPAMFVNGKYQLNPQGMDTSNMDVFVQQYADTVKYLSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A41</accession>
    <name>Q32A41_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Glutamine synthetase</fullName>
            <ecNumber evidence="3 8">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glnA</name>
        <name evidence="10" type="ordered locus">SDY_3873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001271717.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405305.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A41"/>
    <dbReference type="SMR" id="Q32A41"/>
    <dbReference type="STRING" id="300267.SDY_3873"/>
    <dbReference type="EnsemblBacteria" id="ABB63814">
        <property type="protein sequence ID" value="ABB63814"/>
        <property type="gene ID" value="SDY_3873"/>
    </dbReference>
    <dbReference type="GeneID" id="66672224"/>
    <dbReference type="KEGG" id="sdy:SDY_3873"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4580"/>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_6"/>
    <dbReference type="OMA" id="PHPHEFE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="9">
        <location>
            <begin position="102"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="5">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="469" mass="51904" checksum="0AFC05724CDEBA36" modified="2005-12-06" version="1">MSAEHVLTMLNEHEVKFVDLRFTDTKGKEQHVTIPAHQVNAEFFEEGKMFDGSSIGGWKGINESDMVLMPDASTAVIDPFFADSTLIIRCDILEPGTLQGYDRDPRSIAKRAEDYLRSTGIADTVLFGPEPEFFLFDDIRFGSSISGSHVAIDDIEGAWNSSTQYEGGNKGHRPAVKGGYFPVPPVDSAQDIRSEMCLVMEQMGLVVEAHHHEVATAGQNEVATRFNTMTKKADEIQIYKYVVHNVAHRFGKTATFMPKPMFGDNGSGMHCHMSLSKNGVNLFAGDKYAGLSEQALYYIGGVIKHAKAINALANPTTNSYKRLVPGYEAPVMLAYSARNRSASIRIPVVSSPKARRIEVRFPDPAANPYLCFAALLMAGLDGIKNKIHPGEAMDKNLYDLPPEEAKEIPQVAGSLEEALNELDLDREFLKAGGVFTDEAIDAYIALRREEDDRVRMTPHPVEFELYYSV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A80</accession>
    <name>PFKA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent 6-phosphofructokinase isozyme 1</fullName>
            <shortName evidence="1">ATP-PFK 1</shortName>
            <shortName evidence="1">Phosphofructokinase 1</shortName>
            <ecNumber evidence="1">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>6-phosphofructokinase isozyme I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphohexokinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pfkA</name>
        <name type="ordered locus">SDY_3831</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000591795.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405266.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A80"/>
    <dbReference type="SMR" id="Q32A80"/>
    <dbReference type="STRING" id="300267.SDY_3831"/>
    <dbReference type="EnsemblBacteria" id="ABB63775">
        <property type="protein sequence ID" value="ABB63775"/>
        <property type="gene ID" value="SDY_3831"/>
    </dbReference>
    <dbReference type="GeneID" id="66672176"/>
    <dbReference type="KEGG" id="sdy:SDY_3831"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4525"/>
    <dbReference type="HOGENOM" id="CLU_020655_0_1_6"/>
    <dbReference type="OMA" id="KFAVICV"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00763">
        <property type="entry name" value="Bacterial_PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000059789" description="ATP-dependent 6-phosphofructokinase isozyme 1">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="55"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <sequence length="320" mass="34842" checksum="D03D79F6A5536A41" modified="2005-12-06" version="1">MIKKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENIRAVAIENLKKRGIDALVVIGGDGSYMGAMRLTEMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMCDVDELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDIIDAIENMKRPFKGDWLDCAKKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AP0</accession>
    <name>Q32AP0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AP0"/>
    <dbReference type="EnsemblBacteria" id="ABB63615">
        <property type="protein sequence ID" value="ABB63615"/>
        <property type="gene ID" value="SDY_3647"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3647"/>
    <dbReference type="HOGENOM" id="CLU_094152_0_0_6"/>
    <dbReference type="OMA" id="WHNREEN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="240" mass="27851" checksum="7F378EBABB94FA46" modified="2005-12-06" version="1">MQPSPAMQALIEQIYHTFHRYPVPKQCVVCCEYCLSQQEQKALQNTSLRALPYSLINAWNSSPGPDPQNSDEVRYFLPRLLEFVAQGHFDNIHEVFSLRRINLANKANWRADELAILQQFACQYMADWVYGDEAVELQNMLEMFFRADIALAPLLDAVISVPGYQPTVSVACFLWHNREENIQNSSFEQDDDDKAITAQINTWADNNQSILKERSRQAIENPLRQPEQGTRYQVWEENCY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AQ0</accession>
    <name>NIKR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nikR</name>
        <name type="ordered locus">SDY_3636</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="1">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001190062.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405096.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AQ0"/>
    <dbReference type="SMR" id="Q32AQ0"/>
    <dbReference type="STRING" id="300267.SDY_3636"/>
    <dbReference type="EnsemblBacteria" id="ABB63605">
        <property type="protein sequence ID" value="ABB63605"/>
        <property type="gene ID" value="SDY_3636"/>
    </dbReference>
    <dbReference type="GeneID" id="67417111"/>
    <dbReference type="KEGG" id="sdy:SDY_3636"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4315"/>
    <dbReference type="HOGENOM" id="CLU_113319_1_4_6"/>
    <dbReference type="OMA" id="AHNCLET"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010045">
        <property type="term" value="P:response to nickel cation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00476">
        <property type="entry name" value="NikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022988">
        <property type="entry name" value="Ni_resp_reg_NikR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014160">
        <property type="entry name" value="Nickel_NikR_proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02793">
        <property type="entry name" value="nikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000014080" description="Nickel-responsive regulator">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <sequence length="133" mass="15094" checksum="9A9E9F838D3FFEF1" modified="2005-12-06" version="1">MQRVTITLDDDLLETLDSLSQRRGYNNRSEAIRDILRSALAQEATQQHGTQGFAVLSYVYEHEKRDLASRIVSTQHHHHDLSVATLHVHINHDDCLEIAVLKGDMGDVQHFADDVIAQRGVRHGHLQCLPKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AY1</accession>
    <name>Q32AY1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">shuY</name>
        <name evidence="2" type="ordered locus">SDY_3549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000189360.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405015.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AY1"/>
    <dbReference type="STRING" id="300267.SDY_3549"/>
    <dbReference type="EnsemblBacteria" id="ABB63524">
        <property type="protein sequence ID" value="ABB63524"/>
        <property type="gene ID" value="SDY_3549"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3549"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4211"/>
    <dbReference type="HOGENOM" id="CLU_025711_5_0_6"/>
    <dbReference type="OMA" id="GDSWQYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="207" mass="21811" checksum="E2E13BF16E0524ED" modified="2005-12-06" version="1">MTPWLLFGAGGKGVGARTLELALAEQRPVVAVIRHADVATKLAQQGVQVFTGDACDASVVAAACRAAGPDALIISTMGGAQDYLAHRTVIDEAEKAGISRMILVTSLGCGDSWPFLSDRAKAAFGQAVREKTLAESWLQTSQLDYAILRPGGLLDGAATGKALRVQNQECHGFVRRADVAAHIHELANAPALNKQIYSLIEPDLKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AZ0</accession>
    <name>Q32AZ0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhiE</name>
        <name evidence="3" type="ordered locus">SDY_3539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378885.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405006.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AZ0"/>
    <dbReference type="STRING" id="300267.SDY_3539"/>
    <dbReference type="EnsemblBacteria" id="ABB63515">
        <property type="protein sequence ID" value="ABB63515"/>
        <property type="gene ID" value="SDY_3539"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3539"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4199"/>
    <dbReference type="HOGENOM" id="CLU_1522892_0_0_6"/>
    <dbReference type="OMA" id="INNISDM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="175" mass="20614" checksum="5CD1A892D341B367" modified="2005-12-06" version="1">MIFLMTKDSFLLQGFWQLKDNHEMIKINSLSEIKKVGNKPFKLIIDTYHNHILDEEAIKFLEKLDAERIIVLAPYHISKLKAKAPIYFVSRKESIKNLLEITYGKHLPHKNSELCFSHNQFKIMQLILKNKNESNITSTLNISQQTLKIQKFNIMYKLKLRRMSDIVTLGITSYF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B31</accession>
    <name>RL3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplC</name>
        <name type="ordered locus">SDY_3496</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000579833.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404965.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B31"/>
    <dbReference type="SMR" id="Q32B31"/>
    <dbReference type="STRING" id="300267.SDY_3496"/>
    <dbReference type="EnsemblBacteria" id="ABB63474">
        <property type="protein sequence ID" value="ABB63474"/>
        <property type="gene ID" value="SDY_3496"/>
    </dbReference>
    <dbReference type="GeneID" id="67415361"/>
    <dbReference type="KEGG" id="sdy:SDY_3496"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4149"/>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_6"/>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000241410" description="50S ribosomal protein L3">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <sequence length="209" mass="22244" checksum="EA8E10EDD2C0A8FD" modified="2005-12-06" version="1">MIGLVGKKVGMTRIFTEDGVSIPVTVIEVEANRVTQVKDLANDGYRAIQVTTGAKKANRVTKPEAGHFAKAGVEAGRGLWEFRLAEGEEFTVGQSISVELFADVKKVDVTGTSKGKGFAGTVKRWNFRTQDATHGNSLSHRVPGSIGQNQTPGKVFKGKKMAGQMGNERVTVQSLDVVRVDAERNLLLVKGAVPGATGSDLIVKPAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BH7</accession>
    <name>Q32BH7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhbS</name>
        <name evidence="2" type="ordered locus">SDY_3335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000908554.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404819.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BH7"/>
    <dbReference type="SMR" id="Q32BH7"/>
    <dbReference type="STRING" id="300267.SDY_3335"/>
    <dbReference type="EnsemblBacteria" id="ABB63328">
        <property type="protein sequence ID" value="ABB63328"/>
        <property type="gene ID" value="SDY_3335"/>
    </dbReference>
    <dbReference type="GeneID" id="67414907"/>
    <dbReference type="KEGG" id="sdy:SDY_3335"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3989"/>
    <dbReference type="HOGENOM" id="CLU_081840_2_1_6"/>
    <dbReference type="OMA" id="TRCHIGD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="167" mass="18534" checksum="12A71BB4B97E2B18" modified="2005-12-06" version="1">MLIRVEIPIDAPGIDALLRRSFESDAEAKLVHDLREDGFLTLGLVATDDEGQVIGYVAFSPVDVQGEDLQWVGMAPLAVDEKYRGQGLARQLVYEGLDSLNEFGYAAVVTLGDPALYSRFGFELAAHHDLRCRWPGTESAFQVHRLADDALNGVTGLVEYHEHFNRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BH8</accession>
    <name>YHBQ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0213 protein YhbQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yhbQ</name>
        <name type="ordered locus">SDY_3334</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0213 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000189325.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404818.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BH8"/>
    <dbReference type="SMR" id="Q32BH8"/>
    <dbReference type="STRING" id="300267.SDY_3334"/>
    <dbReference type="EnsemblBacteria" id="ABB63327">
        <property type="protein sequence ID" value="ABB63327"/>
        <property type="gene ID" value="SDY_3334"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3334"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3988"/>
    <dbReference type="HOGENOM" id="CLU_135650_0_1_6"/>
    <dbReference type="OMA" id="RLYTGIT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01029">
        <property type="entry name" value="UPF0213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022992">
        <property type="entry name" value="UPF0213_GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000063683" description="UPF0213 protein YhbQ">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01029"/>
        </source>
    </evidence>
    <sequence length="100" mass="11271" checksum="21A10D26B13EE0BC" modified="2005-12-06" version="1">MTPWFLYLIRTADNKLYTGITTDVERRYQQHQSGKGAKALRGKGELTLAFSAPVGDRSLALRAEYRVKQLTKRQKERLVAEGTGFAELLSSLQTPKIKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BP1</accession>
    <name>Q32BP1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000609075.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404755.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BP1"/>
    <dbReference type="EnsemblBacteria" id="ABB63264">
        <property type="protein sequence ID" value="ABB63264"/>
        <property type="gene ID" value="SDY_3264"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3264"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3903"/>
    <dbReference type="HOGENOM" id="CLU_529703_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="479" mass="52913" checksum="6A50DEC42C8E16AB" modified="2005-12-06" version="1">MINLINRNTDCSRGVPDQVNALVATMTDALQPYTAMTNELPEYPNMPGRVLYIPEPFIFCFSGHTITFTNTKRDYNGDNLVNIAVSKDGGNARGDADCALFHAFVTTMLSRSRQPGTYDFFPSLKEEKQGEGMHFMVTPRNSSISTDAIMSQPLLQSQHSWGILNKIINLINADTDEVNELVVAMTNALFLYQTVVRSELQSTEPFRFSFFFSSHTITFTKAESNSKLVQTEVSRGGVTIRECVGSARFRTIAAAMVSCCFSEAAATSQALQQTLHSRVILKLMIKLINADTNRSMVVPDRVNELAVAMTNTLYRYQKVVRADKQIIPESFSFEFSGHTITITPGRYSRSVNLKVCGGGVPACTTADRTLFRTIAAALVSSNQQGTLDFRSSLTFLAEGNLSAENEAIPQLPTRPRVQVRRKVAKRASPPGKNIRSFRSLQPLLMDGNQSAEHESGPQLPSVRARQKGTKRPTLPTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BX6</accession>
    <name>Q32BX6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BX6"/>
    <dbReference type="EnsemblBacteria" id="ABB63179">
        <property type="protein sequence ID" value="ABB63179"/>
        <property type="gene ID" value="SDY_3167"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3167"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="95" mass="10515" checksum="67A4561BD0F2E327" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITHLYSWLNAQLKRSGICANAFRSASSRPGCVEWRGIIASICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C21</accession>
    <name>Q32C21_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yggT</name>
        <name evidence="3" type="ordered locus">SDY_3120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001094831.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404625.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C21"/>
    <dbReference type="STRING" id="300267.SDY_3120"/>
    <dbReference type="EnsemblBacteria" id="ABB63134">
        <property type="protein sequence ID" value="ABB63134"/>
        <property type="gene ID" value="SDY_3120"/>
    </dbReference>
    <dbReference type="GeneID" id="67415156"/>
    <dbReference type="KEGG" id="sdy:SDY_3120"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3730"/>
    <dbReference type="HOGENOM" id="CLU_089905_1_0_6"/>
    <dbReference type="OMA" id="MIDFSPM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="188" mass="21167" checksum="CAE9D2033C049E93" modified="2005-12-06" version="1">MNTLTFLLSTVIELYTMVLLLRIWMQWAHCDFYNPFSQFVVKVTQPIIGPLRRVIPAMGPIDSASLLVAYILSFIKAIVLFKVVTFLPIIWIAGLLILLKTIGLLIFWVLLVMAIMSWVSQGRSPIEYVLIQLADPLLRPIRRLLPAMGGIDFSPMILVLLLYVINMGVAEVLQATGNMLLPGLWMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C38</accession>
    <name>Q32C38_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative general secretion pathway for protein export (GSP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gspL</name>
        <name evidence="11" type="ordered locus">SDY_3101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP L family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404608.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C38"/>
    <dbReference type="STRING" id="300267.SDY_3101"/>
    <dbReference type="EnsemblBacteria" id="ABB63117">
        <property type="protein sequence ID" value="ABB63117"/>
        <property type="gene ID" value="SDY_3101"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3101"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3710"/>
    <dbReference type="HOGENOM" id="CLU_041016_1_0_6"/>
    <dbReference type="OMA" id="PLELPMQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009276">
        <property type="term" value="C:Gram-negative-bacterium-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025691">
        <property type="entry name" value="GspL_pp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007812">
        <property type="entry name" value="T2SS_protein-GspL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12693">
        <property type="entry name" value="GspL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01709">
        <property type="entry name" value="typeII_sec_gspL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GspL_C" evidence="10">
        <location>
            <begin position="128"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="286" mass="32002" checksum="00506F72C1815B34" modified="2005-12-06" version="1">MIHQQHMRNIAQWLQENGITRATVAPDWMSIPCGFMAGDAQRVICRIDECRGWSAGRALAPVMFRAQLNEQDLPLSLTVVGIAPEELSAWAGADAERLTVTALPAITTYGEPEGNLLTGPWQPRVSYRKQWARWRVMILPILLILVALAVERGVTLWSVSEQVAQSRDQAEKQFLTLFPEQKRIVNLRSQVTMALKKYRPQADDTRLLAELSAIASPLKSASLSDIEMCGFTFDQKRQTLHLQLRAANFASFDKLRSALATDYVVQQDALQKEGDAVSGGVMLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C55</accession>
    <name>Q32C55_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_3084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404591.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C55"/>
    <dbReference type="STRING" id="300267.SDY_3084"/>
    <dbReference type="EnsemblBacteria" id="ABB63100">
        <property type="protein sequence ID" value="ABB63100"/>
        <property type="gene ID" value="SDY_3084"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3084"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3691"/>
    <dbReference type="HOGENOM" id="CLU_011226_14_4_6"/>
    <dbReference type="OMA" id="IAVWPWY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="155"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="304" mass="34263" checksum="21D3B146042C9BA7" modified="2005-12-06" version="1">MTCYTASTLPLRRQLTMTDNTYQPAKVWTWDKSAGGAFANINRPVSGPTHEKTLPVGKHPLQLYSLGTPNGQKVTIMLEELFALGVTGAEYDAWLIRIGDGDQFSSGFVEVNPNSKIPALRDHTHNPPIRVFESGSILLYLAEKFGYFLPQDLAKRTETMNWLFWLQGAAPFLGGGFGHFYHYAPVKIEYAINRFTMEAKRLLDVLDKQLAQHKFVAGDEYTIADMAIWPWFGNVVLGGVYDAAEFLDAGSYKHVQRWAKEVGERPAVKRGRIVNRTNGPLNEQLHERHDASDFETNTEDKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CA1</accession>
    <name>Q32CA1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecBCD enzyme subunit RecB</fullName>
            <ecNumber evidence="8">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Exonuclease V subunit RecB</fullName>
            <shortName evidence="8">ExoV subunit RecB</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Helicase/nuclease RecBCD subunit RecB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">recB</name>
        <name evidence="12" type="ordered locus">SDY_3037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001285968.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404545.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CA1"/>
    <dbReference type="STRING" id="300267.SDY_3037"/>
    <dbReference type="EnsemblBacteria" id="ABB63054">
        <property type="protein sequence ID" value="ABB63054"/>
        <property type="gene ID" value="SDY_3037"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3037"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3642"/>
    <dbReference type="HOGENOM" id="CLU_001114_6_0_6"/>
    <dbReference type="OMA" id="KQSIYRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01485">
        <property type="entry name" value="RecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004586">
        <property type="entry name" value="RecB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF23">
        <property type="entry name" value="PTHR11070:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00609">
        <property type="entry name" value="recB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="10">
        <location>
            <begin position="2"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="11">
        <location>
            <begin position="480"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="DNA-binding and helicase activity, interacts with RecC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Nuclease activity, interacts with RecD and RecA" evidence="8">
        <location>
            <begin position="900"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="8">
        <location>
            <position position="1080"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="956"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1067"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1080"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1180" mass="133994" checksum="119D5FF6F2D04EC2" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CA5</accession>
    <name>Q32CA5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane-bound lytic murein transglycosylase A</fullName>
            <ecNumber evidence="4">4.2.2.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Murein hydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltA</name>
        <name evidence="7" type="ordered locus">SDY_3031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>Exolytic cleavage of the (1-&gt;4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.</text>
            <dbReference type="EC" id="4.2.2.n1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.2.n1" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000678645.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404541.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CA5"/>
    <dbReference type="STRING" id="300267.SDY_3031"/>
    <dbReference type="CAZy" id="GH102">
        <property type="family name" value="Glycoside Hydrolase Family 102"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63050">
        <property type="protein sequence ID" value="ABB63050"/>
        <property type="gene ID" value="SDY_3031"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3031"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3638"/>
    <dbReference type="HOGENOM" id="CLU_037751_2_0_6"/>
    <dbReference type="OMA" id="DQNGHPY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14485">
        <property type="entry name" value="mltA_like_LT_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026044">
        <property type="entry name" value="MltA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034654">
        <property type="entry name" value="MltA_3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005300">
        <property type="entry name" value="MltA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30124">
        <property type="entry name" value="PTHR30124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03562">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019422">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00925">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220761" description="Membrane-bound lytic murein transglycosylase A" evidence="5">
        <location>
            <begin position="20"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="MltA" evidence="6">
        <location>
            <begin position="125"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="365" mass="40333" checksum="5ECBB22D1E8D5969" modified="2005-12-06" version="1">MKGRWVKYLLMGTVVAMLAACSSKPTDRGQQYKDGKFTQPFSLVNQPDAVGAPINAGDFAEQINHIRNSSPRLYGNQSNVYNAVQEWLRAGGDTRNMRQFGIDAWQMEGADNYGNVQFTGYYTPVIQARHTRQGEFQYPIYRMPPKRGRLPSRAEIYAGALSDKYILAYSNSLMDNFIMDVQGSGYIDFGDGSPLNFFSYAGKNGHAYRSIGKVLIDRGEVKKEDMSMQAIRHWGETHSEAEVRELLEQNPSFVFFKPQSFAPVKGASAVPLVGRASVASDRSIIPPGTTLLAEVPLLDNNGKFNGQYELRLMVALDVGGAIKGQHFDIYQGIGPEAGHRAGWYNHYGRVWVLKAAPGAGNVVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CA6</accession>
    <name>Q32CA6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ygdL</name>
        <name evidence="3" type="ordered locus">SDY_3030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000117713.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404540.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CA6"/>
    <dbReference type="STRING" id="300267.SDY_3030"/>
    <dbReference type="EnsemblBacteria" id="ABB63049">
        <property type="protein sequence ID" value="ABB63049"/>
        <property type="gene ID" value="SDY_3030"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3030"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3636"/>
    <dbReference type="HOGENOM" id="CLU_013325_4_0_6"/>
    <dbReference type="OMA" id="DMDDICV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="18"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="268" mass="28506" checksum="3AD126D2324F696D" modified="2005-12-06" version="1">MSVVISDAWRQRFGGTARLYGEKALQLFADAHICVVGIGGVGSWAAEALARTGIGAITLIDMDDVCVTNTNRQIHALRDNVGLAKAEVMAERIRQINPECRVTVVDDFVTPDNVAQHMRVGYSYVIDAIDSVRPKAALIAYCRRNKIPLVTTGGAGGQIDPTQIQVTDLAKTIQDPLAAKLRERLKSDFGVVKNSKGKLGVDCVFSTEALVYPQSDGTVCAMKATAEGPKRMDCASGFGAATMVTATFGFVAVSHALKKMMAKAAGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CE1</accession>
    <name>Q32CE1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CE1"/>
    <dbReference type="STRING" id="300267.SDY_2991"/>
    <dbReference type="EnsemblBacteria" id="ABB63014">
        <property type="protein sequence ID" value="ABB63014"/>
        <property type="gene ID" value="SDY_2991"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2991"/>
    <dbReference type="HOGENOM" id="CLU_2540730_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="8745" checksum="3EDF44ADCE7EC8A8" modified="2005-12-06" version="1">MSVKLRLPQTLLCFATPFLAVAIAFTPFGKKVRDLMRDANQPSRHTRSNSSSHYSSSSSSSFDNDNFSGGGGSSGGGGASGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CM8</accession>
    <name>Q32CM8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygaD</name>
        <name evidence="2" type="ordered locus">SDY_2896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019686.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404418.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CM8"/>
    <dbReference type="STRING" id="300267.SDY_2896"/>
    <dbReference type="EnsemblBacteria" id="ABB62927">
        <property type="protein sequence ID" value="ABB62927"/>
        <property type="gene ID" value="SDY_2896"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2896"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3479"/>
    <dbReference type="HOGENOM" id="CLU_030805_1_1_6"/>
    <dbReference type="OMA" id="VEHALNM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="165" mass="17529" checksum="6E76407947EC4913" modified="2005-12-06" version="1">MTDSELMQLSEQVGQALKARGATVTTAESCTGGWVAKVITDIAGSSAWFERGFVTYSNEAKAQMIGVCEETLAQHGAVSEPVVVEMAIGALKAARADYAVSISGIAGPDGGSEEKPVGTVWFAFATARGEGITRRECFSGDRDAVRRQATAYALQTLWQQFLQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CQ5</accession>
    <name>Q32CQ5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ygaM</name>
        <name evidence="12" type="ordered locus">SDY_2863</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ElaB/YgaM/YqjD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404391.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CQ5"/>
    <dbReference type="STRING" id="300267.SDY_2863"/>
    <dbReference type="EnsemblBacteria" id="ABB62900">
        <property type="protein sequence ID" value="ABB62900"/>
        <property type="gene ID" value="SDY_2863"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2863"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3441"/>
    <dbReference type="HOGENOM" id="CLU_132623_4_1_6"/>
    <dbReference type="OMA" id="ARMHGRS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043605">
        <property type="entry name" value="DUF883_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043604">
        <property type="entry name" value="DUF883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010279">
        <property type="entry name" value="YqjD/ElaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35893">
        <property type="entry name" value="PTHR35893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05957">
        <property type="entry name" value="DUF883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19029">
        <property type="entry name" value="DUF883_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DUF883" evidence="10">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DUF883_C" evidence="11">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="113" mass="12288" checksum="871CAD5BE42ED72A" modified="2005-12-06" version="1">MGDHMFNRPNRNDVDDGVQDIQNDVNQLADSLESVLKSWGSDAKGEAEAARSKAQALLKETRARMHGRTRVQQAARDAVGCADSFVRERPWCSVGTAAAVGIFIGALLSMRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CR8</accession>
    <name>Q32CR8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404378.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CR8"/>
    <dbReference type="STRING" id="300267.SDY_2848"/>
    <dbReference type="EnsemblBacteria" id="ABB62887">
        <property type="protein sequence ID" value="ABB62887"/>
        <property type="gene ID" value="SDY_2848"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2848"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3422"/>
    <dbReference type="HOGENOM" id="CLU_112847_0_0_6"/>
    <dbReference type="OMA" id="RTIELYF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="176" mass="20400" checksum="022BC4541B5E8FFD" modified="2005-12-06" version="1">MFTEEEKIRAIELYFKYGKKLAPVVRELGYPSKRNLRRWIRSWEAGGGAKESIRHKHHYSDEQKQVAVEHYLNHGGCLAFTSRALGYPCTDVLARWVNELYPDRRRIFTSKANPVAPFEPEVKRQAVMALCTRQVSASEIARRIGVSRAVLYKWKDEIIGNSAYQTMRKQVMPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CT7</accession>
    <name>Q32CT7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trxC</name>
        <name evidence="5" type="ordered locus">SDY_2825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001098726.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404359.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CT7"/>
    <dbReference type="SMR" id="Q32CT7"/>
    <dbReference type="STRING" id="300267.SDY_2825"/>
    <dbReference type="EnsemblBacteria" id="ABB62868">
        <property type="protein sequence ID" value="ABB62868"/>
        <property type="gene ID" value="SDY_2825"/>
    </dbReference>
    <dbReference type="GeneID" id="67416962"/>
    <dbReference type="KEGG" id="sdy:SDY_2825"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3402"/>
    <dbReference type="HOGENOM" id="CLU_090389_10_0_6"/>
    <dbReference type="OMA" id="QRVDMIN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="139" mass="15555" checksum="4C973F6FE55C8856" modified="2005-12-06" version="1">MNTVCTHCQAINRIPDDRIEDAAKCGRCGHDLFDGEVINATGETLDKLLKDDLPVVIDFWAPWCGPCRNFAPIFEDVAQERSGKVRFVKVNTEAERELSSRFGIRSIPTIMIFKNGQVVDMLNGAVPKAPFDSWLNESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D43</accession>
    <name>Q32D43_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sseA</name>
        <name evidence="4" type="ordered locus">SDY_2717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D43"/>
    <dbReference type="STRING" id="300267.SDY_2717"/>
    <dbReference type="EnsemblBacteria" id="ABB62762">
        <property type="protein sequence ID" value="ABB62762"/>
        <property type="gene ID" value="SDY_2717"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2717"/>
    <dbReference type="HOGENOM" id="CLU_031618_3_0_6"/>
    <dbReference type="OMA" id="QRPGHVP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="70"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="218"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="334" mass="36994" checksum="414CA16CC5F85749" modified="2005-12-06" version="1">MRENLRYVIQYHAHTIRILVRIVAQTAKSASFACRFSLNIRQFSLTPAKMEMPMSTTWFVGADWLTEHIDDPEIQIIDARMASPGQEDRNVAQEYLNGHIPGAVFFDIEALSDHTSPLPHMLPRPETFAVAMRELGVNQDKHLIVYDEGNLFSAPRAWWMLRTFGVEKVSILGGGLAGWQRDDLLLEEGAVELPEGEFNAAFNPEAVVKVTDVLLASHENTAQIIDARPAARFNAEVDEPRPGLCRGHIPGALNVPWTELVREGELKTTDELDAIFFGRGVSYDKPIIVSCGSGVTAAVVLLALATLDVPNVKLYDGAWSEWGARADLPVEPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DD8</accession>
    <name>Q32DD8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS system protein HPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptsH</name>
        <name evidence="5" type="ordered locus">SDY_2612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000487600.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404158.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DD8"/>
    <dbReference type="SMR" id="Q32DD8"/>
    <dbReference type="STRING" id="300267.SDY_2612"/>
    <dbReference type="EnsemblBacteria" id="ABB62667">
        <property type="protein sequence ID" value="ABB62667"/>
        <property type="gene ID" value="SDY_2612"/>
    </dbReference>
    <dbReference type="GeneID" id="64724046"/>
    <dbReference type="GeneID" id="67461150"/>
    <dbReference type="KEGG" id="sdy:SDY_2612"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3149"/>
    <dbReference type="HOGENOM" id="CLU_136230_2_3_6"/>
    <dbReference type="OMA" id="APHGIHT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="85" mass="9119" checksum="E5C8879C0A95AD41" modified="2005-12-06" version="1">MFQQEVTITAPNGLHTRPAAQFVKEAKGFTSEITVTSNGKSASAKSLFKLQTLGLTQGTVVTISAEGEDEQKAVEHLVKLMAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DR2</accession>
    <name>Q32DR2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-quinone oxidoreductase subunit M</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit M</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nuoM</name>
        <name evidence="10" type="ordered locus">SDY_2473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000926423.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404034.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DR2"/>
    <dbReference type="STRING" id="300267.SDY_2473"/>
    <dbReference type="EnsemblBacteria" id="ABB62543">
        <property type="protein sequence ID" value="ABB62543"/>
        <property type="gene ID" value="SDY_2473"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2473"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2984"/>
    <dbReference type="HOGENOM" id="CLU_007100_4_4_6"/>
    <dbReference type="OMA" id="ITRWGNQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="9">
        <location>
            <begin position="134"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="509" mass="56624" checksum="560F9421B508A069" modified="2005-12-06" version="1">MLLPWLILIPFIGGFLCWQTERFGVKVPRWIALITMGLMLALSLQLWLQGGYSLTQSAGIPQWQSEFDMPWIPRFGISIHLAIDGLSLLMVVLTGLLGVLAVLCSWKEIEKYQGFFHLNLMWILGGVIGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHKASDGKTRITAATKFFIYTQASGLVMLIAILALVFVHYNATGVWTFNYEELLNTPMSSGVEYLLMLGFFIAFAVKMPVVPLHGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFSLPLFPNASAEFAPIAMWLGVIGIFYGAWMAFAQTDIKRLIAYTSVSHMGFVLIAIYTGSQLAYQGAVIQMIAHGLSAAGLFILCGQLYERIHTRDMRMMGGLWSKMKWLPALSLFFAVATLGMPGTGNFVGEFMILFGSFQVVPVITVISTFGLVFASVYSLAMLHRAYFGKAKSQIARQELPGMSLRELFMILLLVVLLVLLGFYPQPILDTSHSAIGNIQQWFVNSVTTTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DW6</accession>
    <name>Q32DW6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000147081.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403980.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DW6"/>
    <dbReference type="STRING" id="300267.SDY_2416"/>
    <dbReference type="EnsemblBacteria" id="ABB62489">
        <property type="protein sequence ID" value="ABB62489"/>
        <property type="gene ID" value="SDY_2416"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2416"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2914"/>
    <dbReference type="HOGENOM" id="CLU_066192_18_0_6"/>
    <dbReference type="OMA" id="HALGCRL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="42"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="102" mass="11186" checksum="80586342EC02DCAE" modified="2005-12-06" version="1">MTGKRTLPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISGPSFATLKKFARATGKKLQIRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DX8</accession>
    <name>Q32DX8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybjP</name>
        <name evidence="3" type="ordered locus">SDY_2403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DX8"/>
    <dbReference type="STRING" id="300267.SDY_2403"/>
    <dbReference type="EnsemblBacteria" id="ABB62477">
        <property type="protein sequence ID" value="ABB62477"/>
        <property type="gene ID" value="SDY_2403"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2403"/>
    <dbReference type="HOGENOM" id="CLU_126623_0_0_6"/>
    <dbReference type="OMA" id="PCIDGGP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024289">
        <property type="entry name" value="DUF3828"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12883">
        <property type="entry name" value="DUF3828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3828" evidence="2">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="128" mass="14442" checksum="E1E8F8882BB72E4A" modified="2005-12-06" version="1">MAQQFYDYRIQHRSNDITALRPYLSDKLATLLSDASRDNSHRELLSSDPFSSRTTLPDSAHVASASTIPNRDARNIPLRVDLKQGDQGWQDEVLMIQEGQCWVIDDVRYLGGSVHATAGTLRQSIENR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E30</accession>
    <name>KCY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
            <shortName evidence="1">CK</shortName>
            <ecNumber evidence="1">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine monophosphate kinase</fullName>
            <shortName evidence="1">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cmk</name>
        <name type="ordered locus">SDY_2348</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000125018.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403916.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E30"/>
    <dbReference type="SMR" id="Q32E30"/>
    <dbReference type="STRING" id="300267.SDY_2348"/>
    <dbReference type="EnsemblBacteria" id="ABB62425">
        <property type="protein sequence ID" value="ABB62425"/>
        <property type="gene ID" value="SDY_2348"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2348"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2832"/>
    <dbReference type="HOGENOM" id="CLU_079959_0_2_6"/>
    <dbReference type="OMA" id="RAITWWM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000048283" description="Cytidylate kinase">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <sequence length="227" mass="24686" checksum="AD278B6B13836763" modified="2005-12-06" version="1">MTAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKGSSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQKLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E57</accession>
    <name>Q32E57_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E57"/>
    <dbReference type="STRING" id="300267.SDY_2321"/>
    <dbReference type="EnsemblBacteria" id="ABB62398">
        <property type="protein sequence ID" value="ABB62398"/>
        <property type="gene ID" value="SDY_2321"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2321"/>
    <dbReference type="HOGENOM" id="CLU_1481050_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="182" mass="20186" checksum="1A8F934B2BDE52C4" modified="2005-12-06" version="1">MSLNMFWFLPTHGDGHYLGTEEGSRPVDHGYLQQIAQAADRLGYTGVLIPTGRSCEDAWLVAASMIPVTQRLKFLVALRPSVTSPTVAARQAATLDRLSNGRALFNLVTGSDPQELAGDGVFLDHSERYEASAEFTQVWRQNRLISTSPGANRQNWLKRKSNKCGQKLPRMDAKFVSVFVCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E91</accession>
    <name>Q32E91_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yehB</name>
        <name evidence="4" type="ordered locus">SDY_2287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fimbrial export usher family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403855.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E91"/>
    <dbReference type="STRING" id="300267.SDY_2287"/>
    <dbReference type="EnsemblBacteria" id="ABB62364">
        <property type="protein sequence ID" value="ABB62364"/>
        <property type="gene ID" value="SDY_2287"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2287"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2763"/>
    <dbReference type="HOGENOM" id="CLU_009120_1_0_6"/>
    <dbReference type="OMA" id="YCTITFK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015473">
        <property type="term" value="F:fimbrial usher porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000015">
        <property type="entry name" value="Fimb_usher"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018030">
        <property type="entry name" value="Fimbrial_membr_usher_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042186">
        <property type="entry name" value="FimD_plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025949">
        <property type="entry name" value="PapC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043142">
        <property type="entry name" value="PapC-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30451">
        <property type="entry name" value="PTHR30451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13953">
        <property type="entry name" value="PapC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00577">
        <property type="entry name" value="Usher"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01151">
        <property type="entry name" value="FIMBRIAL_USHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-1029">Fimbrium biogenesis</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PapC_C" evidence="3">
        <location>
            <begin position="524"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="597" mass="66356" checksum="485D65CD065DC779" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ED1</accession>
    <name>COBS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="1">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobS</name>
        <name type="ordered locus">SDY_2241</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021725.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403815.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ED1"/>
    <dbReference type="STRING" id="300267.SDY_2241"/>
    <dbReference type="EnsemblBacteria" id="ABB62324">
        <property type="protein sequence ID" value="ABB62324"/>
        <property type="gene ID" value="SDY_2241"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2241"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2711"/>
    <dbReference type="HOGENOM" id="CLU_057426_1_1_6"/>
    <dbReference type="OMA" id="GHTGDTY"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000045812" description="Adenosylcobinamide-GDP ribazoletransferase">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <sequence length="247" mass="26408" checksum="5D84D2B46CC03689" modified="2005-12-06" version="1">MSKLFWAMLSFITRLPVPRRWSQGLDFEHYSRGIITFPLIGLLLGAISGLVFMVLQAWCGVPLAALFSVLVLALMTGGFHLDGLADTCDGVFSARSRDRMLEIMRDSRLGTHGGLALIFVVLAKILVLSELALRGEPILASLAAACAVSRGIAALLMYRHRYAREEGLGNVFIGKIDGRQTCVTLGLAAIFAAVLLPGMHGVAAMVVTMVAIFILGQLLKRTLGGQTGDTLGAAIELGELVFLLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ED2</accession>
    <name>Q32ED2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bifunctional adenosylcobalamin biosynthesis protein</fullName>
            <ecNumber evidence="12">2.7.1.156</ecNumber>
            <ecNumber evidence="12">2.7.7.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cobU</name>
        <name evidence="15" type="ordered locus">SDY_2240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 12">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 12">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="12"/>
    <dbReference type="EC" id="2.7.7.62" evidence="12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000973159.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403814.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ED2"/>
    <dbReference type="STRING" id="300267.SDY_2240"/>
    <dbReference type="EnsemblBacteria" id="ABB62323">
        <property type="protein sequence ID" value="ABB62323"/>
        <property type="gene ID" value="SDY_2240"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2240"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2710"/>
    <dbReference type="HOGENOM" id="CLU_094161_0_2_6"/>
    <dbReference type="OMA" id="DCLTVWL"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036429">
        <property type="term" value="F:adenosylcobinamide kinase (ATP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036428">
        <property type="term" value="F:adenosylcobinamide kinase (GTP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00544">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="13">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="31"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB62323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="181" mass="20101" checksum="9502BBB1B2A19533" modified="2005-12-06" version="1">MMILVTGGARSGKSRHAEALIGDSSQVLYIATSQILDDEMAARIEHHRQGRPAHWRTVERWQHLDELIHADINPHEAVLLECVTTMVTNLLFDYGGDKDPDEWDYQAMEQAINAEIQSLIAACQRCPAKVVLVTNEVGMGIVPESRLARHFRDIAGRVNQQLAAAANEVWLVVSGIGVKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EG9</accession>
    <name>Q32EG9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yegH</name>
        <name evidence="7" type="ordered locus">SDY_2201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0053 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403777.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EG9"/>
    <dbReference type="STRING" id="300267.SDY_2201"/>
    <dbReference type="EnsemblBacteria" id="ABB62286">
        <property type="protein sequence ID" value="ABB62286"/>
        <property type="gene ID" value="SDY_2201"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2201"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2661"/>
    <dbReference type="HOGENOM" id="CLU_015237_2_0_6"/>
    <dbReference type="OMA" id="SDNPTQR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="319"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="384"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="540" mass="60885" checksum="6D9397ED674F099E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EI4</accession>
    <name>Q32EI4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403762.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EI4"/>
    <dbReference type="EnsemblBacteria" id="ABB62271">
        <property type="protein sequence ID" value="ABB62271"/>
        <property type="gene ID" value="SDY_2185"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2185"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2641"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="EPSAHAC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="271" mass="31381" checksum="517AC4A51F879C15" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQSGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSIPVSRDCAVAYIWLEPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EJ5</accession>
    <name>Q32EJ5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EJ5"/>
    <dbReference type="STRING" id="300267.SDY_2174"/>
    <dbReference type="EnsemblBacteria" id="ABB62260">
        <property type="protein sequence ID" value="ABB62260"/>
        <property type="gene ID" value="SDY_2174"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2174"/>
    <dbReference type="HOGENOM" id="CLU_674207_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="408" mass="45454" checksum="E30254D0DE3576F8" modified="2005-12-06" version="1">MAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITDALPGLLLAFSHRPKETFPLILNFGATELALPIARVWHRFAGQRNLARQWILQWPEHTATALIPLVFTKPSDNSEAALLALCLLYEQGHGELLQTVANRWQRADVWPALEQLLKQGPMDIYPARIPKAPDFWHPAMWSRPRLITNNQPVTDDALEIIGEMLRFTQGGRFYSGLEQLKTFCQPQTLAAFAWDLFTAWQQAGAPAKDNWAFLALSLFGDESTARDLTTQILAWPQEGKSARAVSGLNILTLMNNDMAAAHLHAMALAQLRGHTLPLRTDWLDAIAGSLIKEALNAPLPWSYRGVIHPDTDPILLTLIDTLAGDGFGKLAPSTPQPPLPKDVTCELERTAISLPAELTLNRFNPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EJ7</accession>
    <name>Q32EJ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yehP</name>
        <name evidence="1" type="ordered locus">SDY_2172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EJ7"/>
    <dbReference type="STRING" id="300267.SDY_2172"/>
    <dbReference type="EnsemblBacteria" id="ABB62258">
        <property type="protein sequence ID" value="ABB62258"/>
        <property type="gene ID" value="SDY_2172"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2172"/>
    <dbReference type="HOGENOM" id="CLU_090610_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="230" mass="26612" checksum="D5A75F243F089410" modified="2005-12-06" version="1">MSELNDLLTTRELQRWRLILGEAAETTLCGLDDNARQIDHALEWLYGRDPERLQRGERSGGLGGSNLTTPEWINSIHTLFPQQVIERLEIDAVLRYGIEDVVTNLDVLERMQPSESLLRAVLHTKHLMNPEVLAAARRIVRQVVEEIMARLAKEVRQAFSGVRDRRCRSFIPLARNFDFKSTLRANLQHWHPQHGKLYIESPALTAALNATVNNGNWSYWLIKADRWWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EL6</accession>
    <name>Q32EL6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yohF</name>
        <name evidence="1" type="ordered locus">SDY_2151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000079517.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403730.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EL6"/>
    <dbReference type="STRING" id="300267.SDY_2151"/>
    <dbReference type="EnsemblBacteria" id="ABB62239">
        <property type="protein sequence ID" value="ABB62239"/>
        <property type="gene ID" value="SDY_2151"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2151"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2601"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_6"/>
    <dbReference type="OMA" id="GICEFKE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="253" mass="26909" checksum="5F08B72D5B1C865C" modified="2005-12-06" version="1">MAQVAIITASDSGIGKECALLLAQQGFDIGITWHSDEEGAKDTAREVVSHGVRAEIVQLDLGKLPEGAQALEKLIQRLGRIDVLVNNAGAMTKAPFLDMAFDEWRKIFTVDVDGAFLCSQIAARQMVKQGQGGLIINITSVHEHTPLPDASAYTAAKHALGGLTKAMALELVRHKILVNAVAPGAIATPMNGMDDSDVKPDAEPSIPLRRFGATHEIASLVAWLCSEGANYTTGQSLIVDGGFMLANPQFNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EM5</accession>
    <name>Q32EM5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000383097.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403721.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EM5"/>
    <dbReference type="EnsemblBacteria" id="ABB62230">
        <property type="protein sequence ID" value="ABB62230"/>
        <property type="gene ID" value="SDY_2142"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2142"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2589"/>
    <dbReference type="HOGENOM" id="CLU_196596_0_0_6"/>
    <dbReference type="OMA" id="HADPIQY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020155">
        <property type="entry name" value="Uncharacterised_YeiS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10808">
        <property type="entry name" value="DUF2542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="79" mass="9294" checksum="15EA2EA39301E6DE" modified="2005-12-06" version="1">MDVQQFFVVAVFFLIPIFCFREAWKGWRAGAIDKRVKNAPEPVYVWRAKNPGLFFAYMVAYIGFGILSISMIVYLIFYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EQ3</accession>
    <name>SFGH2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>S-formylglutathione hydrolase YeiG</fullName>
            <shortName>FGH</shortName>
            <ecNumber>3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">yeiG</name>
        <name type="ordered locus">SDY_2112</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>H2O + S-formylglutathione = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000425501.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403693.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EQ3"/>
    <dbReference type="SMR" id="Q32EQ3"/>
    <dbReference type="STRING" id="300267.SDY_2112"/>
    <dbReference type="ESTHER" id="shiss-yeiG">
        <property type="family name" value="A85-EsteraseD-FGH"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62202">
        <property type="protein sequence ID" value="ABB62202"/>
        <property type="gene ID" value="SDY_2112"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2112"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2543"/>
    <dbReference type="HOGENOM" id="CLU_056472_0_0_6"/>
    <dbReference type="OMA" id="TFMEDHL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="PTHR10061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <feature type="chain" id="PRO_0000341676" description="S-formylglutathione hydrolase YeiG">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="278" mass="31369" checksum="3AAD4C18D37FF8F3" modified="2005-12-06" version="1">MEMLEEHRCFQGWQQRWRHDSSTLNCPMTFSIFLPPPRDHTPPPVLYWLSGLTCNDENFTTKAGAQRVAAELGIVLVMPDTSPRGEKVANGDGYDLGQSAGFYLNATQPPWATHYRMYDYLRDELPALVQSQFNVSDRCAISGHSMGGHGALIMALKNPGKYTSVSAFAPIVNPCSVPWGIKAFSRYLGEDKNAWLEWDRCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAARQKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQYLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ET1</accession>
    <name>Q32ET1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mviN</name>
        <name evidence="8" type="synonym">murJ</name>
        <name evidence="10" type="ordered locus">SDY_2083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001050691.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403665.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ET1"/>
    <dbReference type="STRING" id="300267.SDY_2083"/>
    <dbReference type="EnsemblBacteria" id="ABB62174">
        <property type="protein sequence ID" value="ABB62174"/>
        <property type="gene ID" value="SDY_2083"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2083"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2505"/>
    <dbReference type="HOGENOM" id="CLU_006797_5_3_6"/>
    <dbReference type="OMA" id="IFFVAFK"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="511" mass="55342" checksum="372770F2F1D01E07" modified="2005-12-06" version="1">MNLLKSLAAVSSMTMFSRVLGFARDAIVARIFGAGMVTDAFFVAFKLPNLLRRIFAEGAFSQAFVPILAEYKSKQGEDATRVFVSYVSGLLTLALAVVTVAGMLAAPWVIMVTAPGFADTADKFALTSQLLKITFPYILLISLASLVGAILNTWNRFSIPAFAPTLLNISMIGFALFAAPYFNPPVLALAWAVTVGGILQLMYQLPHLKKIGMLVLPRINFHDAGAMRVVKQMGPAILGVSVSQISLIINTIFASFLASGSVSWMYYADRLMEFPSGVLGVALGTILLPSLSKSFASGNHDEYNRLMDWGLRLCFLLALPSAVALGILSGPLTVSLFQYGKFTAFDALMTQRALIAYSVGLIGLIVVKVLAPGFYSRQDIKTPVKIAIVTLILTQLMNLAFIGPLKHAGLSLSIGLAACLNASLLYWQLRKQKIFTPQPGWMAFLLRLVVAVLVMSGVLLGMLHIMPEWSLGTMPWRLLRLMAVVLAGIAAYFAALAVLGFKVKEFARRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EW2</accession>
    <name>Q32EW2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Outer membrane receptor for ferric iron uptake</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fhuE</name>
        <name evidence="14" type="ordered locus">SDY_2048</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000953444.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403634.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EW2"/>
    <dbReference type="STRING" id="300267.SDY_2048"/>
    <dbReference type="EnsemblBacteria" id="ABB62143">
        <property type="protein sequence ID" value="ABB62143"/>
        <property type="gene ID" value="SDY_2048"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2048"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2463"/>
    <dbReference type="HOGENOM" id="CLU_008287_9_3_6"/>
    <dbReference type="OMA" id="GRLDWYD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220813" evidence="11">
        <location>
            <begin position="37"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="13">
        <location>
            <begin position="75"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="12">
        <location>
            <begin position="274"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB62143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="729" mass="81245" checksum="84283DA690FA6A59" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F26</accession>
    <name>PROQ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA chaperone ProQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proQ</name>
        <name type="ordered locus">SDY_1979</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ProQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000431368.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403570.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F26"/>
    <dbReference type="SMR" id="Q32F26"/>
    <dbReference type="STRING" id="300267.SDY_1979"/>
    <dbReference type="EnsemblBacteria" id="ABB62079">
        <property type="protein sequence ID" value="ABB62079"/>
        <property type="gene ID" value="SDY_1979"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1979"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2389"/>
    <dbReference type="HOGENOM" id="CLU_113254_0_0_6"/>
    <dbReference type="OMA" id="WRYLKGV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033592">
        <property type="term" value="F:RNA strand annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034057">
        <property type="term" value="F:RNA strand-exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00749">
        <property type="entry name" value="ProQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023529">
        <property type="entry name" value="ProQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016103">
        <property type="entry name" value="ProQ/FinO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036442">
        <property type="entry name" value="ProQ/FinO_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035236">
        <property type="entry name" value="ProQ_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38106">
        <property type="entry name" value="PTHR38106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04352">
        <property type="entry name" value="ProQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17516">
        <property type="entry name" value="ProQ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00945">
        <property type="entry name" value="ProQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48657">
        <property type="entry name" value="SSF48657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000303099" description="RNA chaperone ProQ">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="232" mass="25834" checksum="019AE4AC55A3C73F" modified="2005-12-06" version="1">MENQPKLNSSKEVIAFLAERFPHCFSAEGEARPLKIGIFQDLVDRVAGEMNLSKTQLRSALRLYTSSWRYLYGVKPGATRVDLDGNPCGELDEQHVEHARKQLEEAKARVQAQRAEQQAKKREAAAAAGEKEDAPRRERKPRPTTPRRKEGAERKPRAQKPVEKAPKTAKAPREEQHTPVSDISALTVGQALKVKAGQNAMDATVLEITKDGVRVQLNSGMSLIVRAEHLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FH8</accession>
    <name>Q32FH8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphofructokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pfkB</name>
        <name evidence="6" type="ordered locus">SDY_1816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022381.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403418.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FH8"/>
    <dbReference type="STRING" id="300267.SDY_1816"/>
    <dbReference type="EnsemblBacteria" id="ABB61927">
        <property type="protein sequence ID" value="ABB61927"/>
        <property type="gene ID" value="SDY_1816"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1816"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2189"/>
    <dbReference type="HOGENOM" id="CLU_050013_0_2_6"/>
    <dbReference type="OMA" id="QLNEPGP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="11"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="309" mass="32488" checksum="7C7CB2DD10C40538" modified="2005-12-06" version="1">MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPMFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQNQGIRCIIDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FT3</accession>
    <name>Q32FT3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="5">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yeaU</name>
        <name evidence="7" type="ordered locus">SDY_1701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-malate + NAD(+) = CO2 + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000978503.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403313.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FT3"/>
    <dbReference type="STRING" id="300267.SDY_1701"/>
    <dbReference type="EnsemblBacteria" id="ABB61822">
        <property type="protein sequence ID" value="ABB61822"/>
        <property type="gene ID" value="SDY_1701"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1701"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2053"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_6"/>
    <dbReference type="OMA" id="KLFRQPS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="6">
        <location>
            <begin position="6"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="361" mass="40317" checksum="7A190747A7D506BB" modified="2005-12-06" version="1">MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNESTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDKRFQQAHNGILAAIEEVIAHGPKTPDMKGSATTPQVADAICKIILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FU3</accession>
    <name>Q32FU3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yoaF</name>
        <name evidence="2" type="ordered locus">SDY_1691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000691935.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403303.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FU3"/>
    <dbReference type="EnsemblBacteria" id="ABB61812">
        <property type="protein sequence ID" value="ABB61812"/>
        <property type="gene ID" value="SDY_1691"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1691"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2038"/>
    <dbReference type="HOGENOM" id="CLU_155318_1_0_6"/>
    <dbReference type="OMA" id="TQCKLPS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005590">
        <property type="entry name" value="DUF333"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03891">
        <property type="entry name" value="DUF333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220825" evidence="1">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="8970" checksum="1749EC2F7360EA16" modified="2005-12-06" version="1">MKIISFVLPCLLVLAGCSTPSQPEAPKPPQIGMVNPASVYCQQKGGTLIPVQTAQGVSNNCKLPGGETIDEWALWRRDHPAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FZ2</accession>
    <name>Q32FZ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SapB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sapB</name>
        <name evidence="8" type="ordered locus">SDY_1639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000583257.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403254.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FZ2"/>
    <dbReference type="STRING" id="300267.SDY_1639"/>
    <dbReference type="EnsemblBacteria" id="ABB61763">
        <property type="protein sequence ID" value="ABB61763"/>
        <property type="gene ID" value="SDY_1639"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1639"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1975"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_3_6"/>
    <dbReference type="OMA" id="RKEWYAN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="74"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="321" mass="36024" checksum="601C78833CB00966" modified="2005-12-06" version="1">MIIFTLRRILLLIVTLFLLTFVGFSLGYFTPHAPLQGASLWNAWVFWFNGLIHWDFGVSSINGQPIAEQLKEVFPSTMELCILAFGFALIVGIPVGMIAGITRHKWQDNLINAIALLGFSIPVFWLALLLTLFCSLTLGWLPVSGRFDLLYEVKPITGFALIDAWLSDSPWRDEMIMSAIRHMILPVITLSVAPTTEVIRLMRISTIEVYDQNYVKAAATRGLSRFTILRRHVLHNALPPVIPRLGLQFSTMLTLAMITEMVFSWPGLGRWLINAIRQQDYAAISAGVMVCGSLVIIVNVISDILGAMANPLKHKEWYALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G03</accession>
    <name>Q32G03_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G03"/>
    <dbReference type="EnsemblBacteria" id="ABB61752">
        <property type="protein sequence ID" value="ABB61752"/>
        <property type="gene ID" value="SDY_1627"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1627"/>
    <dbReference type="HOGENOM" id="CLU_2303343_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="105" mass="12227" checksum="F4911439CEA75744" modified="2005-12-06" version="1">MIVITFNRATFPRLKITMIVRPQQHWLRRIFVWHGSVLSKISSRLLLNFLFSIAVIFMLPWYTHLGIKFTLAPFSILGVAIAIFLGFRNNAGYARYVEARKLWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G20</accession>
    <name>Q32G20_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adhP</name>
        <name evidence="4" type="ordered locus">SDY_1608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G20"/>
    <dbReference type="STRING" id="300267.SDY_1608"/>
    <dbReference type="EnsemblBacteria" id="ABB61735">
        <property type="protein sequence ID" value="ABB61735"/>
        <property type="gene ID" value="SDY_1608"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1608"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_6"/>
    <dbReference type="OMA" id="GLKMTDT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="9"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="375" mass="39514" checksum="FADE55E5197A5710" modified="2005-12-06" version="1">MQNIIRKGGTMKAAVVTKDHHVDVTDKTLRSLKHDEALLKMECCGVCHTDLHVKNGDFGDKTSVILGHEGIGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAQECIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIRPGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEMGADLAINSRTEDAAKIVQEKTGGAHAAVVTAVAKAAFNSAVDAVRAGGHVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLADINTIFTEMEEGKIRGRMVIDFRRSEAFAATASPGVAASHTLQHEMAKWIIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G71</accession>
    <name>Q32G71_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative arginine/ornithine antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_1548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000412385.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403175.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G71"/>
    <dbReference type="STRING" id="300267.SDY_1548"/>
    <dbReference type="EnsemblBacteria" id="ABB61684">
        <property type="protein sequence ID" value="ABB61684"/>
        <property type="gene ID" value="SDY_1548"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1548"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1857"/>
    <dbReference type="HOGENOM" id="CLU_007946_1_2_6"/>
    <dbReference type="OMA" id="FNSDNRV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004754">
        <property type="entry name" value="Amino_acid_antiprt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00905">
        <property type="entry name" value="2A0302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="460" mass="49531" checksum="54A54DE1861FA5A2" modified="2005-12-06" version="1">MEKKLGLSALTALVLSSMLGAGVFSLPQNMAAVASPAALLIGWGITGAGILLLAFAMLILTRIRPELDGGIFTYAREGFGELIGFCSAWGYWLCAVIANVSYLVIVFSALSFFTDTPELRLFGDGNTWQSIVGASALLWIVHFLILRGVQTAASINLVATLAKLLPLGLFVVLAMMMFKLDTFKLDFTGLALGVPVWEQVKNTMLITLWVFIGVEGAVVVSTRARNKRDVGKATLLAVLSALGVYLLVTLLSLGVVARPELAEIRNPSMAGLMVEMMGPWGEIIIAAGLIVSVCGAYLSWTIMAAEVPFLAATHKAFPRIFARQNAQAAPSASLWLTNICVQICLVLIWLTGSDYNTLLTIASEMILVPYFLVGAFLLKIATRPLHKAVGVGACIYGLWLLYASGPMHLLLSVVLYAPGLLVFLYARKTHTHDNVLNRQEMVLIGMLLIASVPATWMLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GF6</accession>
    <name>Q32GF6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative filament protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ynaF</name>
        <name evidence="3" type="ordered locus">SDY_1458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403090.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GF6"/>
    <dbReference type="STRING" id="300267.SDY_1458"/>
    <dbReference type="EnsemblBacteria" id="ABB61599">
        <property type="protein sequence ID" value="ABB61599"/>
        <property type="gene ID" value="SDY_1458"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1458"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1736"/>
    <dbReference type="HOGENOM" id="CLU_049301_12_0_6"/>
    <dbReference type="OMA" id="KNWRTEK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="168" mass="18445" checksum="F9FB9DF2CDEE2AF9" modified="2005-12-06" version="1">MNSVITQKVSSGVTLYADTKTGGFMNRTILVPIDISDSELTQRVISHVEAEAKIDDAEVHFLTVIPSLPYYASLGLAYSAELPAMDDLKAEAKSQLEEIIKKFKLPTDRVHVHVEEGSPKDRILELAKKIPAHMIIIASHRPDITTYLLGSNAAAVVRHAECSVLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GS4</accession>
    <name>Q32GS4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzymes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yciV</name>
        <name evidence="2" type="ordered locus">SDY_1334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001285665.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402972.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GS4"/>
    <dbReference type="STRING" id="300267.SDY_1334"/>
    <dbReference type="EnsemblBacteria" id="ABB61481">
        <property type="protein sequence ID" value="ABB61481"/>
        <property type="gene ID" value="SDY_1334"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1334"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1583"/>
    <dbReference type="HOGENOM" id="CLU_067347_0_0_6"/>
    <dbReference type="OMA" id="CTWGGAT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="293" mass="32626" checksum="E468593C15C31145" modified="2005-12-06" version="1">MSDTNYAVIYDLHSHTTASDGCLTPEALVHRAVEMRVGTLAITDHDTTAAIAPAREEISRSGLALNLIPGVEISTVWENHEIHIVGLNIDITHPLMCEFLAQQTERRNQRAQLIAERLEKAQIPGALEGAQRLAQGGAVTRGHFARFLVECGKASSMADVFKKYLARGKTGYVPPQWCTIEQAIDVIHHSGGKAVLAHPGRYNLSAKWLKRLVAHFAEHHGDAMEVAQCQQSPNERTQLATLARQHHLWASQGSDFHQPCPWIELGRKLWLPTGVEGVWQLWEQLQNTTVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GU1</accession>
    <name>Q32GU1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-CoA thioester hydrolase YciA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yciA</name>
        <name evidence="7" type="ordered locus">SDY_1317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000108160.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402955.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GU1"/>
    <dbReference type="SMR" id="Q32GU1"/>
    <dbReference type="STRING" id="300267.SDY_1317"/>
    <dbReference type="EnsemblBacteria" id="ABB61464">
        <property type="protein sequence ID" value="ABB61464"/>
        <property type="gene ID" value="SDY_1317"/>
    </dbReference>
    <dbReference type="GeneID" id="66674925"/>
    <dbReference type="KEGG" id="sdy:SDY_1317"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1564"/>
    <dbReference type="HOGENOM" id="CLU_050164_2_0_6"/>
    <dbReference type="OMA" id="MDEMAFL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="132" mass="14231" checksum="EF29C49DBB6B50DA" modified="2005-12-06" version="1">MSTTHNVPQGDLVLRTLAMPADTNANGDIFGGWLMSQMDIGGAILAKEIAHGRVVTVRVEGMTFLRPVAVGDVVCCYARCVQKGTTSVSINIEVWVKKVASEPIGQRYKATEALFKYVAVDPEGKPRALPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GU7</accession>
    <name>Q32GU7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GU7"/>
    <dbReference type="EnsemblBacteria" id="ABB61458">
        <property type="protein sequence ID" value="ABB61458"/>
        <property type="gene ID" value="SDY_1311"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1311"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="MRDHEIS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="270" mass="31095" checksum="5DEFADF348BE8F77" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELNGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKRIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRLVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GX7</accession>
    <name>Q32GX7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate reductase 1, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">narH</name>
        <name evidence="2" type="ordered locus">SDY_1280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000702670.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402919.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GX7"/>
    <dbReference type="STRING" id="300267.SDY_1280"/>
    <dbReference type="EnsemblBacteria" id="ABB61428">
        <property type="protein sequence ID" value="ABB61428"/>
        <property type="gene ID" value="SDY_1280"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1280"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1519"/>
    <dbReference type="HOGENOM" id="CLU_043374_5_2_6"/>
    <dbReference type="OMA" id="VYFNWQT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10557">
        <property type="entry name" value="NarH_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="512" mass="58070" checksum="2A5FB9D9D948AA31" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GY4</accession>
    <name>Q32GY4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GY4"/>
    <dbReference type="EnsemblBacteria" id="ABB61421">
        <property type="protein sequence ID" value="ABB61421"/>
        <property type="gene ID" value="SDY_1272"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1272"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8145" checksum="4E3130DE37CB14DE" modified="2005-12-06" version="1">MAVTAAKSVMAFRVMTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITHNFSKVFFPIMIFRRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H43</accession>
    <name>Q32H43_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycgJ</name>
        <name evidence="1" type="ordered locus">SDY_1209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000388335.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402853.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H43"/>
    <dbReference type="STRING" id="300267.SDY_1209"/>
    <dbReference type="EnsemblBacteria" id="ABB61362">
        <property type="protein sequence ID" value="ABB61362"/>
        <property type="gene ID" value="SDY_1209"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1209"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1435"/>
    <dbReference type="HOGENOM" id="CLU_2616694_0_0_6"/>
    <dbReference type="OMA" id="GIFCDVK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008617">
        <property type="entry name" value="Uncharacterised_YcgJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05666">
        <property type="entry name" value="Fels1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="94" mass="10489" checksum="2E70EBE267B03874" modified="2005-12-06" version="1">MEASPACGVVCDPYICVNSDGISPELTRKYLGEKAAENLQSLQGYDPSEFTFANGVFCDVKEKLCRDDRYFGVDGKRSGKINQTTTKMLFMCRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H60</accession>
    <name>FLHD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellar transcriptional regulator FlhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">flhD</name>
        <name type="ordered locus">SDY_1191</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlhD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402836.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H60"/>
    <dbReference type="SMR" id="Q32H60"/>
    <dbReference type="STRING" id="300267.SDY_1191"/>
    <dbReference type="EnsemblBacteria" id="ABB61345">
        <property type="protein sequence ID" value="ABB61345"/>
        <property type="gene ID" value="SDY_1191"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1191"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1409"/>
    <dbReference type="HOGENOM" id="CLU_144160_0_0_6"/>
    <dbReference type="OMA" id="REDKPMG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4000.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00725">
        <property type="entry name" value="FlhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023559">
        <property type="entry name" value="Flagellar_FlhD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036194">
        <property type="entry name" value="FlhD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05247">
        <property type="entry name" value="FlhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63592">
        <property type="entry name" value="SSF63592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000062103" description="Flagellar transcriptional regulator FlhD">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00725"/>
        </source>
    </evidence>
    <sequence length="119" mass="13618" checksum="8432CE64E49177B9" modified="2005-12-06" version="1">MGIMHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMATTLAALTLPQMVKLAETNQLVCHFRFDSHQTITQLTQDSRVDDLQQIHTGIMLSTRLLNDVNQPEEALRKKRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H95</accession>
    <name>SYD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="1">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aspS</name>
        <name type="ordered locus">SDY_1153</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001258651.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402801.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H95"/>
    <dbReference type="SMR" id="Q32H95"/>
    <dbReference type="STRING" id="300267.SDY_1153"/>
    <dbReference type="EnsemblBacteria" id="ABB61310">
        <property type="protein sequence ID" value="ABB61310"/>
        <property type="gene ID" value="SDY_1153"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1153"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1357"/>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_6"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000235557" description="Aspartate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="1">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="534"/>
            <end position="537"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <sequence length="590" mass="65885" checksum="5A903BF2DD2E9572" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HE4</accession>
    <name>Q32HE4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yecC</name>
        <name evidence="8" type="ordered locus">SDY_1100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001272979.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402752.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HE4"/>
    <dbReference type="STRING" id="300267.SDY_1100"/>
    <dbReference type="EnsemblBacteria" id="ABB61261">
        <property type="protein sequence ID" value="ABB61261"/>
        <property type="gene ID" value="SDY_1100"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1100"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1293"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="PEVMFFD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="250" mass="27623" checksum="115E16FDCB7300DA" modified="2005-12-06" version="1">MSAIEVKNLVKKFHGQTVLHGIDLEVKPGEVVAIIGPSGSGKTTLLRSINLLEQPEAGTITVGDITIDTACSLSQQKSLIRQLRQHVGFVFQNFNLFPHRTVLENIIEGPVIVKGEPKEEATARARELLAKVGLAGKETSYPRRLSGGQQQRVAIARALAMRPEVILFDEPTSALDPELVGEVLNTIRQLAQEKRTMVIVTHEMSFARDVADRAIFMDQGRIVEQGAAKALFADPKQPRTRQFLEKFLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HT2</accession>
    <name>Q32HT2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Processor of HyaA and HyaB proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hyaD</name>
        <name evidence="4" type="ordered locus">SDY_0950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000003670.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402614.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HT2"/>
    <dbReference type="STRING" id="300267.SDY_0950"/>
    <dbReference type="MEROPS" id="A31.002"/>
    <dbReference type="EnsemblBacteria" id="ABB61123">
        <property type="protein sequence ID" value="ABB61123"/>
        <property type="gene ID" value="SDY_0950"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0950"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1097"/>
    <dbReference type="HOGENOM" id="CLU_099037_0_1_6"/>
    <dbReference type="OMA" id="MGAKKMS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004419">
        <property type="entry name" value="Pept_A31_hyd_express"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00140">
        <property type="entry name" value="hupD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="195" mass="21531" checksum="119B3BAB4259186F" modified="2005-12-06" version="1">MSEQRVVVMGLGNLLWADEGFGVRVAERLYAHYHWPEYVEIVDGGTQGLNLLGYVESASHLLILDAIDYGLEPGTLRTYAGERIPAYLSAKKMSLHQNSFSEVLALADIRGHLPAHIALVGLQPAMLDDYGGSLSELAREQLPAAEQAALAQLAAWGIVPQPANESRCLNYDCLSMENYEGVRLRQYRMTLEEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HV7</accession>
    <name>Q32HV7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-binding protein Uup</fullName>
            <ecNumber evidence="5">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">uup</name>
        <name evidence="8" type="ordered locus">SDY_0922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Associates with ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000053082.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402589.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HV7"/>
    <dbReference type="STRING" id="300267.SDY_0922"/>
    <dbReference type="EnsemblBacteria" id="ABB61098">
        <property type="protein sequence ID" value="ABB61098"/>
        <property type="gene ID" value="SDY_0922"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0922"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1068"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_6"/>
    <dbReference type="OMA" id="AQADKMR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00848">
        <property type="entry name" value="Uup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043686">
        <property type="entry name" value="Uup"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="320"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="563"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="635" mass="72121" checksum="01A6879E656F1319" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HV9</accession>
    <name>Q32HV9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000224294.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402587.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HV9"/>
    <dbReference type="STRING" id="300267.SDY_0920"/>
    <dbReference type="EnsemblBacteria" id="ABB61096">
        <property type="protein sequence ID" value="ABB61096"/>
        <property type="gene ID" value="SDY_0920"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0920"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1066"/>
    <dbReference type="HOGENOM" id="CLU_028286_0_2_6"/>
    <dbReference type="OMA" id="GYPFLLI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="115"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="289"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="369" mass="40592" checksum="ECE732A1A5BAFE09" modified="2005-12-06" version="1">MATLTRLFIHPVKSMRGIGLTHALADVSGLAFDRIFMITEPDGTFITARQFPQMVRFTPSPVHDGLHLTAPDSSSAYVRFADFATQDAPTEVWGTHFTARIAPEAINKWLSGFFSREVQLRWVGPQMTRRVKRHNTVPLSFADGYPYLLANKASLRDLQQRCPASVKMEQFRPNLVVSGASAWEEDSWKVIRIGDVVFDVVKPCSRCIFTTVSPEKGQKHPAGEPLKTLQSFRTAQDNGDVDFGQNLIARNSGVIRVGDEVEILATAPAKIYGAAAADDTANITQQPDANVDIDWQGQAFRGNNQQVLLEQLENQGIRIPYSCRAGICGSCRVQLLEGEVTPLKNSAMGDDGTILCCSCVPKTALKLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HW3</accession>
    <name>Q32HW3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fimbrial-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402583.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HW3"/>
    <dbReference type="STRING" id="300267.SDY_0916"/>
    <dbReference type="EnsemblBacteria" id="ABB61092">
        <property type="protein sequence ID" value="ABB61092"/>
        <property type="gene ID" value="SDY_0916"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0916"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1062"/>
    <dbReference type="HOGENOM" id="CLU_088965_0_2_6"/>
    <dbReference type="OMA" id="ITAKTCI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000259">
        <property type="entry name" value="Adhesion_dom_fimbrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00419">
        <property type="entry name" value="Fimbrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fimbrial" evidence="1">
        <location>
            <begin position="45"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="187" mass="20449" checksum="5E53C484380DC1C3" modified="2005-12-06" version="1">MRRWFSILIWFTSEGVMLKRIIWILFLLGLTGGGELFAHDGTVNISGSFRRNTCVLAQDSQQINVQLVDVSLTRFFHGNYGPEKSFIINLQDCGTDVSTVDVTFSGTPDGVQSEMLSIESGTDAASGLAIAILDDAKILIPLNQASKDYSLHSGKVPLTFYAQLRPVNSDVQSGKVNASATFVLHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I60</accession>
    <name>Q32I60_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybhN</name>
        <name evidence="2" type="ordered locus">SDY_0815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402486.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I60"/>
    <dbReference type="STRING" id="300267.SDY_0815"/>
    <dbReference type="EnsemblBacteria" id="ABB60997">
        <property type="protein sequence ID" value="ABB60997"/>
        <property type="gene ID" value="SDY_0815"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0815"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.939"/>
    <dbReference type="HOGENOM" id="CLU_056539_1_0_6"/>
    <dbReference type="OMA" id="GALNWSL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="246" mass="28125" checksum="2DD4EE47DD1A8618" modified="2005-12-06" version="1">MSKSHPRWRLAKKILTWLFFIAVIVLLVIYAKKVDWEEVWKVIRDYNRVALLSAVGLVVVSYLIYGCYDLIARFYCGHKLAKRQMMLVSFICYAFNLTLSTWVGGIGMRYRLYSRLGLPGSTITRIFSLSITTNWLGYILLAGIIFTAGVVELPDHWYVDQTTLRILGIGLLMIIAVYLWFCAFAKHLHMTIKGQKLVLPSWKFALAQMLISSVNWMVMGAIIWLLLGHSVNYFFVLGVLLVSSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IE4</accession>
    <name>Q32IE4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IE4"/>
    <dbReference type="EnsemblBacteria" id="ABB60913">
        <property type="protein sequence ID" value="ABB60913"/>
        <property type="gene ID" value="SDY_0729"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0729"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="QFITKDF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="31903" checksum="964595EB3A9BC34F" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYQIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLGVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IM4</accession>
    <name>Q32IM4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deoxyribodipyrimidine photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">phrB</name>
        <name evidence="9" type="ordered locus">SDY_0643</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA photolyase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000207124.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402322.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IM4"/>
    <dbReference type="STRING" id="300267.SDY_0643"/>
    <dbReference type="EnsemblBacteria" id="ABB60833">
        <property type="protein sequence ID" value="ABB60833"/>
        <property type="gene ID" value="SDY_0643"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0643"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.750"/>
    <dbReference type="HOGENOM" id="CLU_010348_2_0_6"/>
    <dbReference type="OMA" id="WQWSASS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="8">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="472" mass="53605" checksum="C97002364FDEADB2" modified="2005-12-06" version="1">MTTHLVWFRQDLRLHDNLALAAACRNSSARVLALYIATPRQWAAHNMSPRQAELINAQLNGLQIALAEKGIPLLFREVDDFAASVEIIKQVCAENSVTHLFYNYQYEVNERARDVEVERALRNVVCEGFDDSVILPPGAVMTGNHEMYKVFTPFQNAWLKRLREGMPECVAAPKVRSSGSIKPAPSITLNYPRQSFDTAHFLVEEKAAIAQLRQFCQNGAGEYEQQRDFPAAEGTSRLSASLATGGLSPRQCLHRLLAEQPQALDGGAGSVWLSELIWREFYRHLMTYYPSLCKHCPFIAWTDRVQWQSNPAHLQAWQEGKTGYPIVDAAMRQLNSTGWMHNRLRMITASFLVKDLLIDWREGERYFMSQLIDGDLAANNGGWQWAASTGTDAAPYFRIFNPTTQGEKFDREGEFIRQWLPELRDVPGKVVHEPWKWAEKAGVKLDYPQPIVEHKEARVQTLAAYEAARKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IT6</accession>
    <name>Q32IT6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative alpha helical protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybeL</name>
        <name evidence="1" type="ordered locus">SDY_0567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001044880.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402260.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IT6"/>
    <dbReference type="STRING" id="300267.SDY_0567"/>
    <dbReference type="EnsemblBacteria" id="ABB60771">
        <property type="protein sequence ID" value="ABB60771"/>
        <property type="gene ID" value="SDY_0567"/>
    </dbReference>
    <dbReference type="GeneID" id="67416315"/>
    <dbReference type="KEGG" id="sdy:SDY_0567"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.670"/>
    <dbReference type="HOGENOM" id="CLU_101353_1_0_6"/>
    <dbReference type="OMA" id="LVCEQCH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009912">
        <property type="entry name" value="DUF1451"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07295">
        <property type="entry name" value="DUF1451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="160" mass="18797" checksum="7976074361E03C13" modified="2005-12-06" version="1">MNKVAQYYRELVASLSERLRNGERDIDALVEQARERVIKTGELTRTEVDELTRAVRRDLEEFAMSYEESLKEESDSVFMRVIKESLWQELADITDKTQLEWREVFQDLNHHGVYHSGEVVGLGNLVCEKCHFHLPIYTPEVLTLCPKCGHDQFQRRPFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IW1</accession>
    <name>Q32IW1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ahpF</name>
        <name evidence="14" type="ordered locus">SDY_0541</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402235.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IW1"/>
    <dbReference type="STRING" id="300267.SDY_0541"/>
    <dbReference type="EnsemblBacteria" id="ABB60746">
        <property type="protein sequence ID" value="ABB60746"/>
        <property type="gene ID" value="SDY_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0541"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.641"/>
    <dbReference type="HOGENOM" id="CLU_031864_0_0_6"/>
    <dbReference type="OMA" id="VTVFEFM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008785">
        <property type="term" value="F:alkyl hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03026">
        <property type="entry name" value="AhpF_NTD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02974">
        <property type="entry name" value="AhpF_NTD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044141">
        <property type="entry name" value="AhpF_NTD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044142">
        <property type="entry name" value="AhpF_NTD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012081">
        <property type="entry name" value="Alkyl_hydroperoxide_Rdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000238">
        <property type="entry name" value="AhpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03140">
        <property type="entry name" value="AhpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="13">
        <location>
            <begin position="136"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="12">
        <location>
            <begin position="223"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="355"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000238-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000238-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB60746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="531" mass="57388" checksum="78D314B8FC60CB8A" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IZ9</accession>
    <name>Q32IZ9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 12">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hemB</name>
        <name evidence="14" type="ordered locus">SDY_0501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402197.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IZ9"/>
    <dbReference type="STRING" id="300267.SDY_0501"/>
    <dbReference type="EnsemblBacteria" id="ABB60708">
        <property type="protein sequence ID" value="ABB60708"/>
        <property type="gene ID" value="SDY_0501"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0501"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.592"/>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_6"/>
    <dbReference type="OMA" id="YMDIIWR"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB60708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="335" mass="36921" checksum="F8F93A16146B848D" modified="2005-12-06" version="1">MHLNSTNIRQTMTDLIQRPRRLRKSPALRAMFEETTLSLNDLVLPIFVEEEIDDYKAVEAMPGVMRIPEKHLAREIERIANAGIRSVMTFGISHHTDETGSDAWREDGLVARMSRICKQTVPEMIVMSDTCFCEYTSHGHCGVLCEHGVDNDATLENLGKQAVVAAAAGADFIAPSAAMDGQVQAIRQALDAAGFKDTAIMSYSTKFASSFYGPFREAAGSALKGDRKSYQMNPMNRREAIRESLLDEAQGADCLMVKPAGAYLDIVRELRERTELPIGAYQVSGEYAMIKFAALAGAIDEEKVVLESLGSIKRAGADLIFSYFALDLAEKKILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J74</accession>
    <name>Q32J74_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J74"/>
    <dbReference type="SMR" id="Q32J74"/>
    <dbReference type="STRING" id="300267.SDY_0422"/>
    <dbReference type="EnsemblBacteria" id="ABB60633">
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        <property type="gene ID" value="SDY_0422"/>
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        <property type="match status" value="14"/>
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        <property type="entry name" value="Big_13"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="match status" value="7"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="146"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="630"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="819"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="941"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1465" mass="145344" checksum="31DB4D44068E4A1B" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JA8</accession>
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        <submittedName>
            <fullName evidence="10">Putative ATP-binding component of a transport system</fullName>
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        <name evidence="10" type="primary">mdlB</name>
        <name evidence="10" type="ordered locus">SDY_0386</name>
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        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="ABB60599">
        <property type="protein sequence ID" value="ABB60599"/>
        <property type="gene ID" value="SDY_0386"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0386"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC1_TM_dom"/>
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        <property type="entry name" value="ABC1_TM_sf"/>
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    </dbReference>
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        <property type="entry name" value="Type_1_exporter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="27"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
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            <end position="574"/>
        </location>
    </feature>
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        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="593" mass="65294" checksum="FEA2DC0C7FE6B646" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JC3</accession>
    <name>Q32JC3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yaiH</name>
        <name evidence="3" type="ordered locus">SDY_0370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000830736.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402073.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JC3"/>
    <dbReference type="SMR" id="Q32JC3"/>
    <dbReference type="STRING" id="300267.SDY_0370"/>
    <dbReference type="MEROPS" id="S12.012"/>
    <dbReference type="EnsemblBacteria" id="ABB60584">
        <property type="protein sequence ID" value="ABB60584"/>
        <property type="gene ID" value="SDY_0370"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0370"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.438"/>
    <dbReference type="HOGENOM" id="CLU_020027_7_1_6"/>
    <dbReference type="OMA" id="CEKDYFA"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
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        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
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        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221162" evidence="1">
        <location>
            <begin position="22"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="389" mass="42348" checksum="56FDDA9D528C35AE" modified="2005-12-06" version="1">MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADHIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSLDQCRRLMVAERGASPCNNTLAAIGSGGVYSTPSDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPASLLIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JI0</accession>
    <name>EX7S_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="1">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="1">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xseB</name>
        <name type="ordered locus">SDY_0308</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001124935.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402016.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JI0"/>
    <dbReference type="SMR" id="Q32JI0"/>
    <dbReference type="STRING" id="300267.SDY_0308"/>
    <dbReference type="EnsemblBacteria" id="ABB60527">
        <property type="protein sequence ID" value="ABB60527"/>
        <property type="gene ID" value="SDY_0308"/>
    </dbReference>
    <dbReference type="GeneID" id="67416503"/>
    <dbReference type="KEGG" id="sdy:SDY_0308"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.354"/>
    <dbReference type="HOGENOM" id="CLU_145918_3_3_6"/>
    <dbReference type="OMA" id="PLNDYKG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000303746" description="Exodeoxyribonuclease 7 small subunit">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <sequence length="80" mass="8952" checksum="8B10380D442CADF4" modified="2005-12-06" version="1">MPKKNEAPASFEKALSELEQIVTRLESGDLPLEEALNEFERGVQLARQGQAKLQQAEQRVQILLSDNEDASLTPFTPDNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-08-10" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JJ5</accession>
    <name>LON_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lon protease</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lon</name>
        <name type="ordered locus">SDY_0293</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Contains an allosteric site (distinct from its active site), whose occupancy by an unfolded polypeptide leads to enzyme activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Organized in a ring with a central cavity. ATP binding and hydrolysis do not affect the oligomeric state of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">By accumulation of abnormal proteins, such as at high temperatures. Under stress conditions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402001.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JJ5"/>
    <dbReference type="BMRB" id="Q32JJ5"/>
    <dbReference type="SMR" id="Q32JJ5"/>
    <dbReference type="STRING" id="300267.SDY_0293"/>
    <dbReference type="MEROPS" id="S16.001"/>
    <dbReference type="EnsemblBacteria" id="ABB60512">
        <property type="protein sequence ID" value="ABB60512"/>
        <property type="gene ID" value="SDY_0293"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0293"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.338"/>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_6"/>
    <dbReference type="OMA" id="GAWQVVD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000396597" description="Lon protease">
        <location>
            <begin position="1"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="592"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="722"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="812" mass="90799" checksum="9CAC33DF727F9EC3" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JK5</accession>
    <name>Q32JK5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401991.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JK5"/>
    <dbReference type="STRING" id="300267.SDY_0283"/>
    <dbReference type="EnsemblBacteria" id="ABB60502">
        <property type="protein sequence ID" value="ABB60502"/>
        <property type="gene ID" value="SDY_0283"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0283"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.325"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="ISVIREH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27503" checksum="695DC2C83C9B3BC1" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREHIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JM1</accession>
    <name>Q32JM1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacteriophage N4 receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nfrB</name>
        <name evidence="4" type="ordered locus">SDY_0266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JM1"/>
    <dbReference type="STRING" id="300267.SDY_0266"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60486">
        <property type="protein sequence ID" value="ABB60486"/>
        <property type="gene ID" value="SDY_0266"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0266"/>
    <dbReference type="HOGENOM" id="CLU_019733_1_0_6"/>
    <dbReference type="OMA" id="KTMHDFP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="116"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSE_N" evidence="2">
        <location>
            <begin position="475"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="654" mass="74525" checksum="F35569BD28065235" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JU3</accession>
    <name>DAPD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="1">THDP succinyltransferase</shortName>
            <shortName evidence="1">THP succinyltransferase</shortName>
            <shortName evidence="1">Tetrahydropicolinate succinylase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapD</name>
        <name type="ordered locus">SDY_0182</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001186643.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401903.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JU3"/>
    <dbReference type="SMR" id="Q32JU3"/>
    <dbReference type="STRING" id="300267.SDY_0182"/>
    <dbReference type="EnsemblBacteria" id="ABB60414">
        <property type="protein sequence ID" value="ABB60414"/>
        <property type="gene ID" value="SDY_0182"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0182"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.211"/>
    <dbReference type="HOGENOM" id="CLU_050859_0_1_6"/>
    <dbReference type="OMA" id="YFPIQKM"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.166.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00811">
        <property type="entry name" value="DapD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005664">
        <property type="entry name" value="DapD_Trfase_Hexpep_rpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023180">
        <property type="entry name" value="THP_succinylTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037133">
        <property type="entry name" value="THP_succinylTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14805">
        <property type="entry name" value="THDPS_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00965">
        <property type="entry name" value="dapD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000047192" description="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00811"/>
        </source>
    </evidence>
    <sequence length="274" mass="29877" checksum="E6A3986C1C2FF52A" modified="2005-12-06" version="1">MQQLQNIIETAFERRAEITPANADTITREAVNQVIALLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVIEGAESRYFDKVPMKFANYDEARFQKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEIVEGVIVEEGSVISMGVYIGQSTKIYDRETGEVHYGRVPAGSVVVSGNLPSKDGKYSLYCAVIVKKVDAKTRGKVGINELLRTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K29</accession>
    <name>Q32K29_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yabI</name>
        <name evidence="4" type="ordered locus">SDY_0092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001148396.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401817.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K29"/>
    <dbReference type="STRING" id="300267.SDY_0092"/>
    <dbReference type="EnsemblBacteria" id="ABB60328">
        <property type="protein sequence ID" value="ABB60328"/>
        <property type="gene ID" value="SDY_0092"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0092"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.108"/>
    <dbReference type="HOGENOM" id="CLU_044208_3_2_6"/>
    <dbReference type="OMA" id="LMPVYRH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="254" mass="28226" checksum="C07B289FBDD14089" modified="2005-12-06" version="1">MQALLEHFITQSTVYSLMAVVLVAFLESLALVGLILPGTVLMAGLGALIGSGELSFWHAWLAGIVGCLLGDWISFWLGWRFKKPLHRWSFLKKNKALLDKTEHALHQHSMFTILVGRFVGPTRPLVPMVAGMLDLPIAKFITPNIIGCLLWPPFYFLPGILAGAAIDIPAGMQSGEFKWLLLVTAVFLWAGGWLCWRLWRSGKATDRLSHYLSRGRLLWLTPLISAIGVVALVVLIRHPLMPVYIDILRKVVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KB4</accession>
    <name>Q32KB4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">thrC</name>
        <name evidence="12" type="ordered locus">SDY_0004</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000781063.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401732.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KB4"/>
    <dbReference type="SMR" id="Q32KB4"/>
    <dbReference type="STRING" id="300267.SDY_0004"/>
    <dbReference type="EnsemblBacteria" id="ABB60244">
        <property type="protein sequence ID" value="ABB60244"/>
        <property type="gene ID" value="SDY_0004"/>
    </dbReference>
    <dbReference type="GeneID" id="58461417"/>
    <dbReference type="KEGG" id="sdy:SDY_0004"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3"/>
    <dbReference type="HOGENOM" id="CLU_015170_0_0_6"/>
    <dbReference type="OMA" id="KGYLCEP"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Thr_synth_N" evidence="11">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PALP" evidence="10">
        <location>
            <begin position="99"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB60244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="428" mass="47084" checksum="020041B36DC42B9B" modified="2005-12-06" version="1">MKLYNLKDHNEQVSFAQAVTQGLGKNQGLFFPHDLPEFSLTEIDEMLKLDFVTRSAKILSAFIGDEIPQEILEERVRAAFAFPAPVANVESDVGCLELFHGPTLAFKDFGGRFMAQMLTHIAGDKPVTILTATSGDTGAAVAHAFYGLPNVKVVILYPRGKISPLQEKLFCTLGGNIETVAIDGDFDACQALVKQAFDDEELKVALGLNSANSINISRLLAQICYYFEAVAQLPQEARNQLVVSVPSGNFGDLTAGLLAKSLGLPVKRFIAATNVNDTVPRFLHDGQWSPKATQATLSNAMDVSQPNNWPRVEELFRRKIWQLKELGYAAVDDETTQQTMRELKELGYTSEPHAAVAYRALRDQLNPGEYGLFLGTAHPAKFKESVEAILGETLDLPKELAERADLPLLSHNLPADFAALRKLMMNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-05-15" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A4SH29</accession>
    <name>A4SH29_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_PA06</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD197_spA</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD197_spA</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000640">
        <property type="protein sequence ID" value="ABO87500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001139949.1">
        <property type="nucleotide sequence ID" value="NC_009344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A4SH29"/>
    <dbReference type="EnsemblBacteria" id="ABO87500">
        <property type="protein sequence ID" value="ABO87500"/>
        <property type="gene ID" value="SDY_PA06"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_PA06"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5784"/>
    <dbReference type="HOGENOM" id="CLU_1085420_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD197_spA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABO87500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="256" mass="29714" checksum="20648248A3A8AC94" modified="2007-05-15" version="1">MCFYLYICTFPFILWSVMGGNKQVVMGVNSDHVVTVYALFSCTLLGCYWLIKRKSFIKRSHIFLLCLVVAYLVINIFVYNHKSITLITSHAVYIVISMWFIFFFKRKPIHLSYLIALGLLFVSSFLLIKLFQLGFGDWGRLTVPVFYDNSWSYFPLGYESSSDPNVLAFMLCIGSIYMFFTLPNKYTINIIFILSMMCSFLTLSRSSFLSFFYFLSYCKCLFILCAKENTAKVVGTNYDFTCNVFCSDEKHSRCSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>P0C1B2</accession>
    <name>ULAE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Putative L-ribulose-5-phosphate 3-epimerase UlaE</fullName>
            <ecNumber evidence="1">5.1.3.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-ascorbate utilization protein E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">L-xylulose-5-phosphate 3-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ulaE</name>
        <name type="ordered locus">SDY_4366</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-ribulose 5-phosphate = L-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:18497"/>
            <dbReference type="ChEBI" id="CHEBI:57829"/>
            <dbReference type="ChEBI" id="CHEBI:58226"/>
            <dbReference type="EC" id="5.1.3.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor degradation; L-ascorbate degradation; D-xylulose 5-phosphate from L-ascorbate: step 3/4.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">Induced by L-ascorbate. Repressed by UlaR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the L-ribulose-5-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Could be the product of a pseudogene.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous termination">
            <sequence resource="EMBL" id="CP000034"/>
        </conflict>
        <text>Truncated C-terminus.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0C1B2"/>
    <dbReference type="SMR" id="P0C1B2"/>
    <dbReference type="UniPathway" id="UPA00263">
        <property type="reaction ID" value="UER00379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034015">
        <property type="term" value="F:L-ribulose-5-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019854">
        <property type="term" value="P:L-ascorbic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01951">
        <property type="entry name" value="UlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004560">
        <property type="entry name" value="L-Ru-5P_3-Epase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023492">
        <property type="entry name" value="L-Ru-5P_3-Epase_Enterobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00542">
        <property type="entry name" value="hxl6Piso_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="uncertain"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000233258" description="Putative L-ribulose-5-phosphate 3-epimerase UlaE">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="284" mass="32025" checksum="7AD1E12028975896" modified="2006-05-02" version="1">MLSKQIPLGIYEKALPAGECWLERLQLAKTLGFDFVEMSVDETDERLSRLDWSREQRLALVNAIVETGVRVPSMCLSAHRRFPLGSEDDAVRAQGLEIMRKAIQFAQDVGIRGIQLAGYDVYYQEANNETRRRFRDGLKESVEMASRAQVTLAMEIMDYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGMGHIVAVHVKDTKPGVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAEDPAAEVAKARDWVKARMAKAGMVEAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>P0CB30</accession>
    <name>ARNE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE</fullName>
            <shortName evidence="1">L-Ara4N-phosphoundecaprenol flippase subunit ArnE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">arnE</name>
        <name type="ordered locus">SDY_2453.1</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of ArnE and ArnF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArnE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000638028.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CB30"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901505">
        <property type="term" value="F:carbohydrate derivative transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042221">
        <property type="term" value="P:response to chemical"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01869">
        <property type="entry name" value="Flippase_ArnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022883">
        <property type="entry name" value="Flippase_ArnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000383006" description="Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01869"/>
        </source>
    </evidence>
    <sequence length="111" mass="12219" checksum="67702E6E5DA33D69" modified="2009-09-01" version="1">MIWLTLVFASLLSVAGQLCQKQATCFVAINKRRKHIVLWLGLALACLGLAMVLWLLVLQNVPVGIAYPMLNLNFVWVTLAAVKLWHEPVSPRHWCGVAFIIGGIVILGSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q326U6</accession>
    <name>Q326U6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISSfl4 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406150.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326U6"/>
    <dbReference type="EnsemblBacteria" id="ABB64662">
        <property type="protein sequence ID" value="ABB64662"/>
        <property type="gene ID" value="SDY_P149"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P149"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5706"/>
    <dbReference type="HOGENOM" id="CLU_113764_2_0_6"/>
    <dbReference type="OMA" id="FWRKNHG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="195" mass="22319" checksum="46D596E19924632A" modified="2005-12-06" version="1">MNSQTTKDIPCFRSYLPDALRLRLEDKLTIRAIAQRLGLSHSTIHTLFQRFLASGIAWPLPDSVSFAQLNAILYANRKKELTEPQIREGSWRKERRTSYSREFKVRLAKQALQPGAVVARIAREHDINDNLLFKWKSQYEDGLLSDDDIQECMPVPVALTDTPEPTRPVTNPFWRKNHGSLAAANRGVAEYELSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q327B0</accession>
    <name>Q327B0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406086.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327B0"/>
    <dbReference type="EnsemblBacteria" id="ABB64598">
        <property type="protein sequence ID" value="ABB64598"/>
        <property type="gene ID" value="SDY_P085"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P085"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5635"/>
    <dbReference type="HOGENOM" id="CLU_2358156_0_0_6"/>
    <dbReference type="OMA" id="NAHWISK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="96" mass="11096" checksum="5572DDD4ECDFB29D" modified="2005-12-06" version="1">MNAHWISKKSNILRKNIKLLTKYLFFESQGIPDKVDIVSRLKTYGYSISGVETDDGYKALVRAFQLHFRQKNYDGIMDAETAAILYALLEKYFPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q327J6</accession>
    <name>Q327J6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Negative response regulator of genes in aerobic pathways</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">arcA</name>
        <name evidence="6" type="ordered locus">SDY_4662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001194358.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406000.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327J6"/>
    <dbReference type="SMR" id="Q327J6"/>
    <dbReference type="STRING" id="300267.SDY_4662"/>
    <dbReference type="EnsemblBacteria" id="ABB64509">
        <property type="protein sequence ID" value="ABB64509"/>
        <property type="gene ID" value="SDY_4662"/>
    </dbReference>
    <dbReference type="GeneID" id="67416078"/>
    <dbReference type="KEGG" id="sdy:SDY_4662"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5527"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_6"/>
    <dbReference type="OMA" id="VWGWDFG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="238" mass="27292" checksum="9316CF4DE8EABDE8" modified="2005-12-06" version="1">MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSEYDINLVIMDINLPGKNGLLLARELREQANVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRSVESYKFNGWELDINSRSLIGPDGEQYKLPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q327P4</accession>
    <name>Q327P4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327P4"/>
    <dbReference type="STRING" id="300267.SDY_4603"/>
    <dbReference type="EnsemblBacteria" id="ABB64461">
        <property type="protein sequence ID" value="ABB64461"/>
        <property type="gene ID" value="SDY_4603"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4603"/>
    <dbReference type="HOGENOM" id="CLU_198234_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="76" mass="8996" checksum="F4EACA5C759AFF79" modified="2005-12-06" version="1">MKATEARLLDFLKRSQQFVIPIYQRTYSWTEQQCRQLWDDIIRAGKRDDISAHFIGSVVYIEQGVMLPISRTCVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q327T8</accession>
    <name>Q327T8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhjH</name>
        <name evidence="2" type="ordered locus">SDY_4545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405908.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327T8"/>
    <dbReference type="STRING" id="300267.SDY_4545"/>
    <dbReference type="EnsemblBacteria" id="ABB64417">
        <property type="protein sequence ID" value="ABB64417"/>
        <property type="gene ID" value="SDY_4545"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4545"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5373"/>
    <dbReference type="HOGENOM" id="CLU_089254_0_0_6"/>
    <dbReference type="OMA" id="CGMANFS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="14"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="256" mass="29732" checksum="D82C18AA01F1B51A" modified="2005-12-06" version="1">MMIRQVIQRISNPEASIESLQERRFWLQCERAYTWQPIYQTCGRLMAVELLTVVTHPLNPSQRLPPDRYFTEITVSHRMEVVKEQIDLLAQKADFFIEHGLLASVNIDGPTLIALRQQPKILRQIERLPWLRFELVEHIRLPKDSTFASMCEFGPLWLDDFGTGMANFSALSEVRYDYIKIARELFVMLRQSPEGRTLFSQLLHLMNRYCRGVIVEGVETPEEWRDVQNSPAFAAQGWFLSRPAPIETLNTAVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q328H6</accession>
    <name>Q328H6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SugE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sugE</name>
        <name evidence="6" type="ordered locus">SDY_4392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328H6"/>
    <dbReference type="STRING" id="300267.SDY_4392"/>
    <dbReference type="EnsemblBacteria" id="ABB64279">
        <property type="protein sequence ID" value="ABB64279"/>
        <property type="gene ID" value="SDY_4392"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4392"/>
    <dbReference type="HOGENOM" id="CLU_133067_1_1_6"/>
    <dbReference type="OMA" id="FEIAWAI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042221">
        <property type="term" value="P:response to chemical"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="155" mass="16251" checksum="09CCFD09D966FFE3" modified="2005-12-06" version="1">MPFVFSAIVTKVIVEIPLPPGKISVQSSALQDDLQTRLFTGDGPNSPEPDMSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSVITVTAMIVSMALLSWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGESANPMRLASLALIVLGIIGLKLSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q328L3</accession>
    <name>Q328L3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Biotin sulfoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bisC</name>
        <name evidence="6" type="ordered locus">SDY_4352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405733.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328L3"/>
    <dbReference type="STRING" id="300267.SDY_4352"/>
    <dbReference type="EnsemblBacteria" id="ABB64242">
        <property type="protein sequence ID" value="ABB64242"/>
        <property type="gene ID" value="SDY_4352"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4352"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5136"/>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_6"/>
    <dbReference type="OMA" id="LEPDEWH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02793">
        <property type="entry name" value="MopB_CT_DMSOR-BSOR-TMAOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006658">
        <property type="entry name" value="BisC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041954">
        <property type="entry name" value="CT_DMSOR/BSOR/TMAOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00509">
        <property type="entry name" value="bisC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="4">
        <location>
            <begin position="18"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="5">
        <location>
            <begin position="598"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="739" mass="82072" checksum="BCEC1B114285CF9E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q328R0</accession>
    <name>Q328R0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fecI</name>
        <name evidence="6" type="ordered locus">SDY_4299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001283879.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405686.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328R0"/>
    <dbReference type="STRING" id="300267.SDY_4299"/>
    <dbReference type="EnsemblBacteria" id="ABB64195">
        <property type="protein sequence ID" value="ABB64195"/>
        <property type="gene ID" value="SDY_4299"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4299"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5069"/>
    <dbReference type="HOGENOM" id="CLU_047691_12_1_6"/>
    <dbReference type="OMA" id="NPRAYLY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="5">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="173" mass="19538" checksum="F4E46729CD9FDACC" modified="2005-12-06" version="1">MSDRSTTTASLTFESLYGTHHGWLKSWLTRKLQSAFDADDIAQDTFLRVMVSETLSTIRDPRSFLCTIAKRVMVDLFRRNALEKAYLEMLALMPEGGAPSPEERESRLETLQLLDSMLDGLNGKTREAFLLSQLDGLTYSEIAHKLAVSISSVKKYVAKAVEHCLLFRLEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q328T5</accession>
    <name>Q328T5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjgJ</name>
        <name evidence="1" type="ordered locus">SDY_4269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328T5"/>
    <dbReference type="STRING" id="300267.SDY_4269"/>
    <dbReference type="EnsemblBacteria" id="ABB64170">
        <property type="protein sequence ID" value="ABB64170"/>
        <property type="gene ID" value="SDY_4269"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4269"/>
    <dbReference type="HOGENOM" id="CLU_2548387_0_0_6"/>
    <dbReference type="OMA" id="QARDIAX"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="9188" checksum="0DAAA56830C4935D" modified="2005-12-06" version="1">MVLEGIHSHDPQARDIAVQYYHAAETAIYDYIARRHPQSAQCVTDFMSTVMSGLSAKAREGHSLEQLCATAALAGEAIKTILKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q329I3</accession>
    <name>PHNC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphonates import ATP-binding protein PhnC</fullName>
            <ecNumber evidence="1">7.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">phnC</name>
        <name type="ordered locus">SDY_4111</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + phosphonate(out) = ADP + H(+) + phosphate + phosphonate(in)</text>
            <dbReference type="Rhea" id="RHEA:18065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16215"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.3.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.3.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001193416.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405513.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329I3"/>
    <dbReference type="SMR" id="Q329I3"/>
    <dbReference type="STRING" id="300267.SDY_4111"/>
    <dbReference type="EnsemblBacteria" id="ABB64022">
        <property type="protein sequence ID" value="ABB64022"/>
        <property type="gene ID" value="SDY_4111"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4111"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4835"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="GRMPRWR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03256">
        <property type="entry name" value="ABC_PhnC_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012693">
        <property type="entry name" value="ABC_transpr_PhnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02315">
        <property type="entry name" value="ABC_phnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51249">
        <property type="entry name" value="PHNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0918">Phosphonate transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000274751" description="Phosphonates import ATP-binding protein PhnC">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="5"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01713"/>
        </source>
    </evidence>
    <sequence length="262" mass="29512" checksum="3EC0C0AF7DEB55D3" modified="2005-12-06" version="1">MQTIIRVEKLAKTFNQHQALHAVDLNIHHGEMVALLGPSGSGKSTLLRHLSGLIVGDKKPECRVELLGCTVQQNGRLARDIRKSRANTGYIFQQFNLVNRLSVLENVLIGALGSTPFWRTCFSWFTREQKQRALQALTRVGMVHFAHQRVSTLSGGQQQRVAIARALMQQAKVILADEPIASLDPESARIVMDTLRDINQNDGITVVVTLHQVDYALRYCERIVALRQGHVFYDGSSQLFDNDRFDHLYRSINRVEENAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q329V9</accession>
    <name>Q329V9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA</name>
        <name evidence="7" type="ordered locus">SDY_3968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405387.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329V9"/>
    <dbReference type="SMR" id="Q329V9"/>
    <dbReference type="STRING" id="300267.SDY_3968"/>
    <dbReference type="EnsemblBacteria" id="ABB63896">
        <property type="protein sequence ID" value="ABB63896"/>
        <property type="gene ID" value="SDY_3968"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3968"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4679"/>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_6"/>
    <dbReference type="OMA" id="QVGVAPK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="127" mass="14035" checksum="0ADDC33C915A55E5" modified="2005-12-06" version="1">MLHQQRNQHARLIPVELYMSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A07</accession>
    <name>METE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metE</name>
        <name type="ordered locus">SDY_3914</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000153924.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405339.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A07"/>
    <dbReference type="SMR" id="Q32A07"/>
    <dbReference type="STRING" id="300267.SDY_3914"/>
    <dbReference type="EnsemblBacteria" id="ABB63848">
        <property type="protein sequence ID" value="ABB63848"/>
        <property type="gene ID" value="SDY_3914"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3914"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4622"/>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_6"/>
    <dbReference type="OMA" id="KVMKGML"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000017273" description="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase">
        <location>
            <begin position="1"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="694"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="431"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="431"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="515"/>
            <end position="516"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <sequence length="753" mass="84744" checksum="1E27E414C1620321" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A49</accession>
    <name>Q32A49_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A49"/>
    <dbReference type="EnsemblBacteria" id="ABB63806">
        <property type="protein sequence ID" value="ABB63806"/>
        <property type="gene ID" value="SDY_3864"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3864"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="7726" checksum="DA891CE13555F813" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITPAFLLLINFPRFLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A88</accession>
    <name>Q32A88_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yiiS</name>
        <name evidence="2" type="ordered locus">SDY_3822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0381 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000655985.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405258.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A88"/>
    <dbReference type="STRING" id="300267.SDY_3822"/>
    <dbReference type="EnsemblBacteria" id="ABB63767">
        <property type="protein sequence ID" value="ABB63767"/>
        <property type="gene ID" value="SDY_3822"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3822"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4513"/>
    <dbReference type="HOGENOM" id="CLU_162758_0_0_6"/>
    <dbReference type="OMA" id="SCQAEKI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005272">
        <property type="entry name" value="CHP00743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38769">
        <property type="entry name" value="PTHR38769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04175">
        <property type="entry name" value="DUF406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00743">
        <property type="entry name" value="TIGR00743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="107" mass="11741" checksum="E18AADA27F8331E6" modified="2005-12-06" version="1">MKDVVDKCSTKGCAIDIGTVIDNDNCTSKFSRFFATREEAESFMTKLKELAAAASSADEGASVAYKIKDLEGLVELDAAFTFSCQAEMIIFELSLRSLASWSCFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A93</accession>
    <name>Q32A93_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Facilitated diffusion of glycerol</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glpF</name>
        <name evidence="8" type="ordered locus">SDY_3817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000084263.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405253.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A93"/>
    <dbReference type="STRING" id="300267.SDY_3817"/>
    <dbReference type="EnsemblBacteria" id="ABB63762">
        <property type="protein sequence ID" value="ABB63762"/>
        <property type="gene ID" value="SDY_3817"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3817"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4508"/>
    <dbReference type="HOGENOM" id="CLU_020019_9_3_6"/>
    <dbReference type="OMA" id="MTRTGMF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="281" mass="29812" checksum="12E565B79B73D261" modified="2005-12-06" version="1">MSQTSTLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKVIPFIVSQVAGAFCAAALVYGLYYNLFFDFEQTHHIVRGSVESVDLAGTFSTYPNPHINFMQAFAVEMVITAILMGLILALTDDGNGVPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWLAGWGNVAFTGGRDIPYFLVPLFGPIVGAIVGAFAYRKLIGRHLPCDICVVEEKETTTPSEQKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AA6</accession>
    <name>Q32AA6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein FtsN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">ftsN</name>
        <name evidence="4" type="ordered locus">SDY_3804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with FtsA via its N-terminal cytoplasmic domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes to the septum. Localizes to the midcell via interaction with the early cell division protein FtsA and via the periplasmic SPOR domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000068837.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405240.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AA6"/>
    <dbReference type="STRING" id="300267.SDY_3804"/>
    <dbReference type="EnsemblBacteria" id="ABB63749">
        <property type="protein sequence ID" value="ABB63749"/>
        <property type="gene ID" value="SDY_3804"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3804"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4494"/>
    <dbReference type="HOGENOM" id="CLU_058902_0_0_6"/>
    <dbReference type="OMA" id="NRPEEVW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02039">
        <property type="entry name" value="FtsN_entero"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011930">
        <property type="entry name" value="FtsN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02223">
        <property type="entry name" value="ftsN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0717">Septation</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="242"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="252"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="319" mass="35837" checksum="21DAE7634CE3BF23" modified="2005-12-06" version="1">MAQRDYVRRSQPAPSRRKKSTSRKKQRNLPAVSPAMVAIAAAVLVTFIGGLYFITHHKKEESETLQSQKVTGNGLPPKPEERWRYIKELESRQPGVRAPTEPSAGGEVKTPEQLTPEQRQLLEQMQADMRQQPTQLVEVPWNEQTPEQRQQTLQRQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQPYQDLLQTPAHTTAQSKPQQAAPVTRAADAPKPTAEKKDERRWMVQCGSFRGAEQAETVRAQLAFEGFDSKITTNNGWNRVVIGPVKGKENADSTLNRLKMAGHTNCIRLAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AD9</accession>
    <name>Q32AD9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hippuricase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AD9"/>
    <dbReference type="STRING" id="300267.SDY_3770"/>
    <dbReference type="EnsemblBacteria" id="ABB63716">
        <property type="protein sequence ID" value="ABB63716"/>
        <property type="gene ID" value="SDY_3770"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3770"/>
    <dbReference type="HOGENOM" id="CLU_023257_3_0_6"/>
    <dbReference type="OMA" id="RAHACGH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="184"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="296" mass="32753" checksum="731894BF605A587A" modified="2005-12-06" version="1">MIEHYIRGFEEELREIRHQIHENPELGLQEFKTSALVAEKLRQWGYEVEQGLATTGIVATLKVGDGVKSIGLRADMDALPIYENSGKPWASKHPGLMHACGHDGHTTILLGAARYFAETRRFNGTLRLIFQPAEEMINGGEIMVKEGLFDHFPCDVIFGMHNMPGLPVGKFYFQPGALMASMDQFHITVRGCGGHGAIPHKAIDPVLVAAHITTALQSIVSRNVDPLEAAVITVGSIVAGEAANVIPDSAEMKISVRSLSRDTRQLLLTLFLLWHKPRLPALALRLRLRMLTVHQY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AQ2</accession>
    <name>NIKD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nickel import ATP-binding protein NikD</fullName>
            <ecNumber evidence="1">7.2.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nikD</name>
        <name type="ordered locus">SDY_3634</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001136199.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405094.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AQ2"/>
    <dbReference type="SMR" id="Q32AQ2"/>
    <dbReference type="STRING" id="300267.SDY_3634"/>
    <dbReference type="EnsemblBacteria" id="ABB63603">
        <property type="protein sequence ID" value="ABB63603"/>
        <property type="gene ID" value="SDY_3634"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3634"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4313"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_6"/>
    <dbReference type="OMA" id="AFIMQNP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015413">
        <property type="term" value="F:ABC-type nickel transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014138">
        <property type="entry name" value="Nickel_NikD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02770">
        <property type="entry name" value="nickel_nikD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51247">
        <property type="entry name" value="NIKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-0921">Nickel transport</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000274117" description="Nickel import ATP-binding protein NikD">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01711"/>
        </source>
    </evidence>
    <sequence length="254" mass="26761" checksum="FDFB2BEDD1425BF8" modified="2005-12-06" version="1">MPQQIELRDIALQAAQPLVHGVSLTLQRGRVLALVGGSGSGKSLTCAAALGILPAGVRQTAGEILADGKPVSPCALRGIKIATIMQNPRSAFNPLHTMHTHARETCLALGKPADDATLTAAIEAVGLENAARVLKLYPFEMSGGMLQRMMIAMAVLCESPFIIADEPTTDLDVVAQARILDLLESIMQKQAPGMLLVTHDMGVVARLADDVAVMSDGKIVEQGDVETLFNAPKHAVTRSLVSAHLALYGMELAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AV4</accession>
    <name>GLGX_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="1">3.2.1.196</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Limit dextrin alpha-1,6-maltotetraose-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgX</name>
        <name type="ordered locus">SDY_3577</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic linkages to branches with degrees of polymerization of three or four glucose residues in limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.196"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; glycogen degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.196" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000192515.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405042.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AV4"/>
    <dbReference type="SMR" id="Q32AV4"/>
    <dbReference type="STRING" id="300267.SDY_3577"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63551">
        <property type="protein sequence ID" value="ABB63551"/>
        <property type="gene ID" value="SDY_3577"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3577"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4248"/>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_6"/>
    <dbReference type="OMA" id="SEPWDCG"/>
    <dbReference type="UniPathway" id="UPA00165"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01248">
        <property type="entry name" value="GlgX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040784">
        <property type="entry name" value="GlgX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022844">
        <property type="entry name" value="Glycogen_debranch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18390">
        <property type="entry name" value="GlgX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0321">Glycogen metabolism</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000067106" description="Glycogen debranching enzyme">
        <location>
            <begin position="1"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="657" mass="73648" checksum="49497E4EB337BC3B" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AY5</accession>
    <name>Q32AY5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acid stress chaperone HdeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">hdeB</name>
        <name evidence="4" type="ordered locus">SDY_3544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HdeB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405011.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AY5"/>
    <dbReference type="STRING" id="300267.SDY_3544"/>
    <dbReference type="EnsemblBacteria" id="ABB63520">
        <property type="protein sequence ID" value="ABB63520"/>
        <property type="gene ID" value="SDY_3544"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3544"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4204"/>
    <dbReference type="HOGENOM" id="CLU_149189_1_0_6"/>
    <dbReference type="OMA" id="VAFWMLN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990451">
        <property type="term" value="P:cellular stress response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.890.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00947">
        <property type="entry name" value="HdeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038303">
        <property type="entry name" value="HdeA/HdeB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028623">
        <property type="entry name" value="HdeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010486">
        <property type="entry name" value="HNS-dep_expression_A/B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06411">
        <property type="entry name" value="HdeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019125" description="Acid stress chaperone HdeB" evidence="3">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="12504" checksum="E106B08279989BFF" modified="2005-12-06" version="1" precursor="true">MGYKMNISSLRKAFIFMGAVAALSLVNAQSALAANESAKDMTCQEFIDLNPKAMTPVAWWLLHEETVYKGGDTVTLNETDLTQIPKVIEYCKKNPQKNLYTFKNQASNDLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B10</accession>
    <name>Q32B10_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yhfA</name>
        <name evidence="1" type="ordered locus">SDY_3518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001148908.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404986.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B10"/>
    <dbReference type="SMR" id="Q32B10"/>
    <dbReference type="STRING" id="300267.SDY_3518"/>
    <dbReference type="EnsemblBacteria" id="ABB63495">
        <property type="protein sequence ID" value="ABB63495"/>
        <property type="gene ID" value="SDY_3518"/>
    </dbReference>
    <dbReference type="GeneID" id="67416988"/>
    <dbReference type="KEGG" id="sdy:SDY_3518"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4173"/>
    <dbReference type="HOGENOM" id="CLU_114057_1_2_6"/>
    <dbReference type="OMA" id="GPRPMEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="134" mass="14517" checksum="CF55FD536E0EDE4E" modified="2005-12-06" version="1">MQARVKWVEGLTFLGESASGHQILMDGNSGDKAPSPMEMVLMAAGGCSAIDVVSILQKGRQDVVDCEVKLTSERREEAPRLFTHINLHFIVTGRDLKDAAVARAVDLSAEKYCSVALMLEKAVNITHSYEVVAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B62</accession>
    <name>FMT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fmt</name>
        <name type="ordered locus">SDY_3464</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000004453.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404934.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B62"/>
    <dbReference type="SMR" id="Q32B62"/>
    <dbReference type="STRING" id="300267.SDY_3464"/>
    <dbReference type="EnsemblBacteria" id="ABB63443">
        <property type="protein sequence ID" value="ABB63443"/>
        <property type="gene ID" value="SDY_3464"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3464"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4117"/>
    <dbReference type="HOGENOM" id="CLU_033347_1_2_6"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000020163" description="Methionyl-tRNA formyltransferase">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <sequence length="315" mass="34126" checksum="2E9CFA5BB2A77B1B" modified="2005-12-06" version="1">MSESLRIIFAGTPDFAARHLDALLSSGHNVVGVFTQPDRPAGRGKKLMPSPVKVLAEEKGLPVFQPVSLRPQENQQLVADLQADVMVVVAYGLILPKAVLEMPRLGCINVHGSLLPRWRGAAPIQRSLWAGDAETGVTIMQMDVGLDTGDMLYKLSCPITAEDTSGTLYDKLAELGPQGLITTLKQLADGTAKPEVQDETLVTYAEKLSKEEARIDWSLSAAQLERCIRAFNPWPMSWLEIEGQPVKVWKASVIDTATNAAPGTILEANKQGIQVATGDGILNLLSLQPAGKKAMSAQDLLNSRREWFVPGNRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B85</accession>
    <name>Q32B85_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000626000.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404911.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B85"/>
    <dbReference type="EnsemblBacteria" id="ABB63419">
        <property type="protein sequence ID" value="ABB63419"/>
        <property type="gene ID" value="SDY_3429"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3429"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4087"/>
    <dbReference type="HOGENOM" id="CLU_1007359_0_0_6"/>
    <dbReference type="OMA" id="WRERLEV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="241" mass="27416" checksum="1FBE4666727C95F0" modified="2005-12-06" version="1">MISTDHKLMRIDTGHQTVEITLDDAYKRYQAAPDPLQEVAADMLKQLAEMLPTGRCIVPVIKEKAWLDTVRQQLSQYESDPELLNASLDFAWEDFNDELIILFAEDGSETMRYLMRYEVTIDREQAISNLKQILPEVTAEIVDTGANDGKVAVISAGGTYEPSLMLIDDLWVQSPDPECGDLLVTVPSRGKLFFTHNDQPANLSALRQLTEQCFREDDHPLTTQIFIRCNGHFYPWVETLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BB3</accession>
    <name>NANR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional repressor NanR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nanR</name>
        <name type="ordered locus">SDY_3401</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NanR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000523846.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404883.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BB3"/>
    <dbReference type="SMR" id="Q32BB3"/>
    <dbReference type="STRING" id="300267.SDY_3401"/>
    <dbReference type="PRIDE" id="Q32BB3"/>
    <dbReference type="EnsemblBacteria" id="ABB63392">
        <property type="protein sequence ID" value="ABB63392"/>
        <property type="gene ID" value="SDY_3401"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3401"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4057"/>
    <dbReference type="HOGENOM" id="CLU_017584_9_1_6"/>
    <dbReference type="OMA" id="HDAFVDW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01236">
        <property type="entry name" value="HTH_NanR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023730">
        <property type="entry name" value="Tscrpt_reg_NanR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000301528" description="HTH-type transcriptional repressor NanR">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="263" mass="29550" checksum="306B289AAD7D8BB6" modified="2005-12-06" version="1">MGLMNAFDSQTEDSSPAIGRNLRSRPLARKKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTIIGELSGMAKDFLSHPGGIAHFEQLRLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNNAAFIRSDVDFHRVLAEIPGNPIFMAIHVALLDWLIAARPTVTDQALHEHNNVSYQQHIAIVDAIRRHDPDEADRALQSHLNSVSATWYAFGQTTNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BM5</accession>
    <name>Q32BM5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yqjA</name>
        <name evidence="4" type="ordered locus">SDY_3282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000422149.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404771.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BM5"/>
    <dbReference type="STRING" id="300267.SDY_3282"/>
    <dbReference type="EnsemblBacteria" id="ABB63280">
        <property type="protein sequence ID" value="ABB63280"/>
        <property type="gene ID" value="SDY_3282"/>
    </dbReference>
    <dbReference type="GeneID" id="67414958"/>
    <dbReference type="KEGG" id="sdy:SDY_3282"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3924"/>
    <dbReference type="HOGENOM" id="CLU_044208_6_2_6"/>
    <dbReference type="OMA" id="SNARFQF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="220" mass="24585" checksum="07EE88184D420201" modified="2005-12-06" version="1">MELLTQLLQALWAQDFETLANPSMIGMLYFVLFVILFLENGLLPAAFLPGDSLLVLVGVLIAKGAMGYPQTILLLTVAASLGCWVSYIQGRWLGNTRTVQNWLSHLPAHYHQRAHHLFHKHGLSALLIGRFIAFVRTLLPTIAGLSGLNNARFQFFNWMSGLLWVLILTTLGYMLGKTPVFLKYEDQLMSCLMLLPVVLLVFGLAGSLVVLWKKKYGNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BN3</accession>
    <name>Q32BN3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative membrane-bound redox modulator Alx</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ygjT</name>
        <name evidence="9" type="ordered locus">SDY_3273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has been proposed to be a redox modulator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001098812.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404763.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BN3"/>
    <dbReference type="STRING" id="300267.SDY_3273"/>
    <dbReference type="EnsemblBacteria" id="ABB63272">
        <property type="protein sequence ID" value="ABB63272"/>
        <property type="gene ID" value="SDY_3273"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3273"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3914"/>
    <dbReference type="HOGENOM" id="CLU_045644_1_2_6"/>
    <dbReference type="OMA" id="ADHAREY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="321" mass="36022" checksum="A8EC5D09853CF472" modified="2005-12-06" version="1">MNTVGTPLLWGGFAVVVAIMLAIDLLLQGRRGAHAMTMKQAAAWSLVWVTLSLLFNAAFWWYLVQTEGRAVADPQALAFLTGYLIEKSLAVDNVFVWLMLFSYFSVPAALQRRVLVYGVLGAIVLRTIMIFTGSWLISQFDWILYIFGAFLLFTGVKMALAHEDESGIGNKPLVRWLRGHLRMTDTIDNEHFFVRKNGLLYATPLMLVLILVELSDVIFAVDSIPAIFAVITDPFIVLTSNLFAILGLRAMYFLLASVAERFSMLKYGLAVILVFIGIKMLIVDFYHIPIAVSLGVVFGILVMTFIINAWVNYRHDKQRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C15</accession>
    <name>Q32C15_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="4 10">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yggJ</name>
        <name evidence="11" type="ordered locus">SDY_3126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="4 10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C15"/>
    <dbReference type="STRING" id="300267.SDY_3126"/>
    <dbReference type="EnsemblBacteria" id="ABB63140">
        <property type="protein sequence ID" value="ABB63140"/>
        <property type="gene ID" value="SDY_3126"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3126"/>
    <dbReference type="HOGENOM" id="CLU_067442_5_1_6"/>
    <dbReference type="OMA" id="TQWKGER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="252" mass="28052" checksum="1C1059C7B0E66269" modified="2005-12-06" version="1">MGRRRGFLTMRIPRIYHPEPLTSHSHIALCEDAANHIGRVLRMGPGQALQLFDGSNQVFDAEITSASKKSVEVKVLEGQIDDRESPLHIHLGQVMSRGEKMEFTIQKSIELGVSLITPLFSKRCGVKLDSERLNKKLQQWQKIAIAACEQCGRNRVPEIRPAMDLEAWCAEQDEGLKLNLHPRASNSINTLPLPVERVRLLIGPEGGLSADEIAMTARYQFTDILLGPRVLRTETTALTAITALQVRFGDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CA0</accession>
    <name>Q32CA0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protease 3</fullName>
            <ecNumber evidence="4">3.4.24.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Pitrilysin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protease III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protease pi</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ptr</name>
        <name evidence="18" type="ordered locus">SDY_3038</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.55" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001138224.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404546.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CA0"/>
    <dbReference type="STRING" id="300267.SDY_3038"/>
    <dbReference type="MEROPS" id="M16.001"/>
    <dbReference type="EnsemblBacteria" id="ABB63055">
        <property type="protein sequence ID" value="ABB63055"/>
        <property type="gene ID" value="SDY_3038"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3038"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3643"/>
    <dbReference type="HOGENOM" id="CLU_004639_1_3_6"/>
    <dbReference type="OMA" id="WIFDEMK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221030" description="Protease 3" evidence="14">
        <location>
            <begin position="24"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="15">
        <location>
            <begin position="54"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="16">
        <location>
            <begin position="216"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_M" evidence="17">
        <location>
            <begin position="400"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="16">
        <location>
            <begin position="681"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB63055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="962" mass="107795" checksum="D9F9A6A265026C26" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CB8</accession>
    <name>Q32CB8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-fuculose phosphate aldolase</fullName>
            <ecNumber evidence="5">4.1.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-ribulose-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-fuculose-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">fucA</name>
        <name evidence="7" type="ordered locus">SDY_3017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:12933"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57846"/>
            <dbReference type="EC" id="4.1.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aldolase class II family. AraD/FucA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.17" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000440781.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404528.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CB8"/>
    <dbReference type="SMR" id="Q32CB8"/>
    <dbReference type="STRING" id="300267.SDY_3017"/>
    <dbReference type="EnsemblBacteria" id="ABB63037">
        <property type="protein sequence ID" value="ABB63037"/>
        <property type="gene ID" value="SDY_3017"/>
    </dbReference>
    <dbReference type="GeneID" id="58459968"/>
    <dbReference type="KEGG" id="sdy:SDY_3017"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3621"/>
    <dbReference type="HOGENOM" id="CLU_006033_3_0_6"/>
    <dbReference type="OMA" id="YATFGTH"/>
    <dbReference type="UniPathway" id="UPA00563">
        <property type="reaction ID" value="UER00626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042355">
        <property type="term" value="P:L-fucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00987">
        <property type="entry name" value="FucA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004782">
        <property type="entry name" value="FucA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01086">
        <property type="entry name" value="fucA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 5" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aldolase_II" evidence="6">
        <location>
            <begin position="8"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Plays a key role in the stabilization of the transition state and positioning the aldehyde component" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="site" description="Plays a key role in the stabilization of the transition state and positioning the aldehyde component" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="site" description="Plays a key role in the stabilization of the transition state and positioning the aldehyde component" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="215" mass="23775" checksum="BA9897E13ABE4A22" modified="2005-12-06" version="1">MERNKLARQIIDTCLEMTRLGLNQGTAGNVSVRYQDGMLITPTGIPYEKLTESHIVFIDGNGKHEEGKLPSSEWRFHMAAYQSRPDANAVVHNHAVHCTAVSILNRSIPAIHYMIAAAGGNSIPCAPYATFGTRELSEHVALALKNRKATLLQHHGLIACEVNLEKALWLAHEVEVLAQLYLTTLAITDPVPVLSDEEIAVVLEKFKTYGLRIEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CH8</accession>
    <name>CYSD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sulfate adenylate transferase</fullName>
            <shortName evidence="1">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysD</name>
        <name type="ordered locus">SDY_2951</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer composed of CysD, the smaller subunit, and CysN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000372107.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404468.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CH8"/>
    <dbReference type="SMR" id="Q32CH8"/>
    <dbReference type="STRING" id="300267.SDY_2951"/>
    <dbReference type="EnsemblBacteria" id="ABB62977">
        <property type="protein sequence ID" value="ABB62977"/>
        <property type="gene ID" value="SDY_2951"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2951"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3543"/>
    <dbReference type="HOGENOM" id="CLU_043026_0_0_6"/>
    <dbReference type="OMA" id="LMIDTGH"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00064">
        <property type="entry name" value="Sulf_adenylyltr_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000008994" description="Sulfate adenylyltransferase subunit 2">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00064"/>
        </source>
    </evidence>
    <sequence length="302" mass="35244" checksum="023576DA3D9C6A94" modified="2005-12-06" version="1">MDQIRLTHLRQLEAESIHIIREVAAEFSNPVMLYSIGKDSSVMLHLARKAFYPGTLPFPLLHVDTGWKFREMYEFRDRTAKAYGCELLVHKNPEGVAMGINPFIHGSAKHTDIMKTEGLKQALNKYGFDAAFVGARRDEEKSRAKERIYSFRDRFHRWDPKNQRPELWHNYNGQINKGESIRVFPLSNWTEQDIWQYIWLENIDIVPLYLAAERPVLERDGMLMMIDDNRIDLQPGEVIKKRMVRFRTLGCWPLTGAVESNAQTLPEIIEEMLVSTTSERQGRVIDRDQAGSMELKKRQGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CS5</accession>
    <name>Q32CS5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ISSfl4 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000622996.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404371.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CS5"/>
    <dbReference type="STRING" id="300267.SDY_2841"/>
    <dbReference type="EnsemblBacteria" id="ABB62880">
        <property type="protein sequence ID" value="ABB62880"/>
        <property type="gene ID" value="SDY_2841"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2841"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3414"/>
    <dbReference type="HOGENOM" id="CLU_128110_1_0_6"/>
    <dbReference type="OMA" id="TEDKFRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008878">
        <property type="entry name" value="Transposase_IS66_Orf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36455">
        <property type="entry name" value="PTHR36455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05717">
        <property type="entry name" value="TnpB_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="106" mass="12058" checksum="EF32D68B6051FF14" modified="2005-12-06" version="1">MISFPAGSRIWLVAGITDMRNGFNGLASKVQNVLKDDPFSGHLFIFRGRRGDQIKVLWADSDGLCLFTRRLERGRFVWPVTRDGKVHLTPAQLSMLLEGIDWKRCP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CY1</accession>
    <name>TRMD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmD</name>
        <name type="ordered locus">SDY_2781</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000264777.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404315.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CY1"/>
    <dbReference type="SMR" id="Q32CY1"/>
    <dbReference type="STRING" id="300267.SDY_2781"/>
    <dbReference type="EnsemblBacteria" id="ABB62824">
        <property type="protein sequence ID" value="ABB62824"/>
        <property type="gene ID" value="SDY_2781"/>
    </dbReference>
    <dbReference type="GeneID" id="66673504"/>
    <dbReference type="KEGG" id="sdy:SDY_2781"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3352"/>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_6"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000257468" description="tRNA (guanine-N(1)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <sequence length="255" mass="28422" checksum="B101087229B4CDBD" modified="2005-12-06" version="1">MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D05</accession>
    <name>Q32D05_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D05"/>
    <dbReference type="EnsemblBacteria" id="ABB62800">
        <property type="protein sequence ID" value="ABB62800"/>
        <property type="gene ID" value="SDY_2757"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2757"/>
    <dbReference type="HOGENOM" id="CLU_110174_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025484">
        <property type="entry name" value="DUF4376"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14301">
        <property type="entry name" value="DUF4376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4376" evidence="1">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="121" mass="13961" checksum="5369C51AB559A6A3" modified="2005-12-06" version="1">MLEAAREARRQGIEAWRTEQEAKPFTFEWNGRIWNAGPNSLGRLYPVVMAAKSDIVRDVMTWSDADNQQVQLTMQELEGLATAMIQAIVDRNDEIYRRQREMKEELSGLDDLASIRAFDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D16</accession>
    <name>Q32D16_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yfhK</name>
        <name evidence="6" type="ordered locus">SDY_2746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404280.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D16"/>
    <dbReference type="STRING" id="300267.SDY_2746"/>
    <dbReference type="EnsemblBacteria" id="ABB62789">
        <property type="protein sequence ID" value="ABB62789"/>
        <property type="gene ID" value="SDY_2746"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2746"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3311"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_23_6"/>
    <dbReference type="OMA" id="IAQDCIK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="277"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="496" mass="55676" checksum="51FAEDDD837BCD4C" modified="2005-12-06" version="1">MLYLNFPSVSIRLFASDESNTLKRWPVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEMERSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLPDDKLYQALRQDLNNLAQLQCNNSGPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFGWQSLVLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLSERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQKLIEQLLDYNRKQADSAVELENVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSKNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D18</accession>
    <name>Q32D18_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative 2-component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yfhA</name>
        <name evidence="10" type="ordered locus">SDY_2744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005017348.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404278.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D18"/>
    <dbReference type="STRING" id="300267.SDY_2744"/>
    <dbReference type="EnsemblBacteria" id="ABB62787">
        <property type="protein sequence ID" value="ABB62787"/>
        <property type="gene ID" value="SDY_2744"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2744"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3309"/>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_6"/>
    <dbReference type="OMA" id="YRAVVMS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="8">
        <location>
            <begin position="136"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="444" mass="49078" checksum="FB3C8A63CFFE04ED" modified="2005-12-06" version="1">MSHKPAHLLLVDDDPGLLKLLGLRLTSEGYSVVTAESGAEGLRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILTAHGSIPDAVAATQQGVFSFLTKPVDKDALYQAIDDALEQSAPATDERWREAIVTRSPLMLRLLEQARLVAQSDVSVLINGQSGTGKEIFAQAIHNASPRNSKPFIAINCGALPEQLLESELFGHARGAFTGAVSNREGLFQAAEGGTLFLDEIGDMPAPLQVKLLRVLQERKVRPLGSNRDIDIDVRIISATHRDLPKAMARGEFREDLYYRLNVVSLKIPALAERTEDIPLLANHLLRQAAERHKPFVRAFSTDAMKRLITASWPGNVRQLVNVIEQCVALTSSPVISDALVEQALEGENTALPTFVEARNQFELNYLCKLLQITKGNVTHAARMAGRNRTEFYKLLSRHELDANDFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DD7</accession>
    <name>Q32DD7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ptsI</name>
        <name evidence="20" type="ordered locus">SDY_2613</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000623136.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404159.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DD7"/>
    <dbReference type="SMR" id="Q32DD7"/>
    <dbReference type="STRING" id="300267.SDY_2613"/>
    <dbReference type="EnsemblBacteria" id="ABB62668">
        <property type="protein sequence ID" value="ABB62668"/>
        <property type="gene ID" value="SDY_2613"/>
    </dbReference>
    <dbReference type="GeneID" id="66673713"/>
    <dbReference type="KEGG" id="sdy:SDY_2613"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3150"/>
    <dbReference type="HOGENOM" id="CLU_007308_7_0_6"/>
    <dbReference type="OMA" id="CNAEWAL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="19">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="17">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="18">
        <location>
            <begin position="250"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="454"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ABB62668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="575" mass="63534" checksum="B9C5344D6AE827B2" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DJ2</accession>
    <name>Q32DJ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0381 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404104.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DJ2"/>
    <dbReference type="STRING" id="300267.SDY_2544"/>
    <dbReference type="EnsemblBacteria" id="ABB62613">
        <property type="protein sequence ID" value="ABB62613"/>
        <property type="gene ID" value="SDY_2544"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2544"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3062"/>
    <dbReference type="HOGENOM" id="CLU_162758_0_0_6"/>
    <dbReference type="OMA" id="CQAEAMI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005272">
        <property type="entry name" value="CHP00743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38769">
        <property type="entry name" value="PTHR38769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04175">
        <property type="entry name" value="DUF406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00743">
        <property type="entry name" value="TIGR00743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="102" mass="11272" checksum="287D92677318C302" modified="2005-12-06" version="1">MHIQRKSTMSKCSADETPVCCCMDVGTIMDNSDCTASYSRVFANRAEAEQTLAALTEKARSVESEPCKISPTFTEESDGVRLDVDFTFACEAEMLIFQLGLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DL8</accession>
    <name>TRUA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="1">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truA</name>
        <name type="ordered locus">SDY_2517</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001283590.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404078.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DL8"/>
    <dbReference type="SMR" id="Q32DL8"/>
    <dbReference type="STRING" id="300267.SDY_2517"/>
    <dbReference type="EnsemblBacteria" id="ABB62587">
        <property type="protein sequence ID" value="ABB62587"/>
        <property type="gene ID" value="SDY_2517"/>
    </dbReference>
    <dbReference type="GeneID" id="66673799"/>
    <dbReference type="KEGG" id="sdy:SDY_2517"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3032"/>
    <dbReference type="HOGENOM" id="CLU_014673_0_2_6"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000017176" description="tRNA pseudouridine synthase A">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="1">
        <location>
            <begin position="107"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="168"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA; Important for base-flipping" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <sequence length="270" mass="30385" checksum="9F1FD578B011D878" modified="2005-12-06" version="1">MSDQQQPPVYKIALGIEYDGSKYYGWQRQNEVRSVQEKLEKALSQVANEPITVFCAGRTDAGVHGTGQVVHFETTAQRKDAAWTLGVNANLPGDIAVRWVKAVPDDFHARFSATARRYRYIIYNHRLRPAVLSKGVTHFYEPLDAERMHRAAQCLLGENDFTSFRAVQCQSRTPWRNVMHINVTRHGPYVVVDIKANAFVHHMVRNIVGSLMEVGAHNQPESWIAELLAAKDRTLAAATAKAEGLYLVAVDYPDRYDLPKPPMGPLFLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DP9</accession>
    <name>Q32DP9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000074531.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404047.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DP9"/>
    <dbReference type="STRING" id="300267.SDY_2486"/>
    <dbReference type="EnsemblBacteria" id="ABB62556">
        <property type="protein sequence ID" value="ABB62556"/>
        <property type="gene ID" value="SDY_2486"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2486"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2997"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_6"/>
    <dbReference type="OMA" id="WRMGWII"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="58"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="405" mass="45521" checksum="889A78836FD8AD26" modified="2005-12-06" version="1">MSPIEKSSKLENVCYDIRGPVLKEAKRLEEEGNKVLKLNIGNPAPFGFDAPDEILVDVIRNLPTAQGYCDSKGLYSARKAIMQHYQARGMRDVTVEDIYIGNGVSELIVQAMQALLNSGDEMLVPAPDYPLWTAAVSLSSGKAVHYLCDESSDWFPDLDDIRAKITPRTRGIVIINPNNPTGAVYSKELLMEIVEIARQHNLIIFADEIYDKILYDDAEHHSIATLAPDLLTITFNGLSKTYRVAGFRQGWMVLNGPKKHAKGYIEGLEMLASMRLCANVPAQHAIQTALGGYQSISEFITPGGRLYEQRNRAWELINDIPGVSCVKPRGALYMFPKIDAKRFNIHDDQKMVLDFLLQEKVLLVQGTAFNWPWPDHFRIVTLPRVDDIELSLSKFARFLSGYHQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DQ2</accession>
    <name>NUOB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name type="ordered locus">SDY_2483</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000386732.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404044.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DQ2"/>
    <dbReference type="SMR" id="Q32DQ2"/>
    <dbReference type="STRING" id="300267.SDY_2483"/>
    <dbReference type="EnsemblBacteria" id="ABB62553">
        <property type="protein sequence ID" value="ABB62553"/>
        <property type="gene ID" value="SDY_2483"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2483"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2994"/>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_6"/>
    <dbReference type="OMA" id="GPYWEHG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000376377" description="NADH-quinone oxidoreductase subunit B">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <sequence length="220" mass="25070" checksum="EBD62682E2074680" modified="2005-12-06" version="1">MDYTLTRIDPNGENDRYPLQKQEIVTDPLEQEVNKNVFMGKLNDMVNWGRKNSIWPYNFGLSCCYVEMVTSFTAVHDVARFGAEVLRASPRQADLMVVAGTCFTKMAPVIQRLYDQMLEPKWVISMGACANSGGMYDIYSVVQGVDKFIPVDVYIPGCPPRPEAYMQALMLLQESIAKERRPLSWVVGDQGVYRANMQSERERKRGERIAVTNLRTPDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DQ6</accession>
    <name>Q32DQ6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADH-quinone oxidoreductase</fullName>
            <ecNumber evidence="14">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">nuoG</name>
        <name evidence="18" type="ordered locus">SDY_2479</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="function">
        <text evidence="3">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="14">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="14"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404040.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DQ6"/>
    <dbReference type="STRING" id="300267.SDY_2479"/>
    <dbReference type="EnsemblBacteria" id="ABB62549">
        <property type="protein sequence ID" value="ABB62549"/>
        <property type="gene ID" value="SDY_2479"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2479"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2990"/>
    <dbReference type="HOGENOM" id="CLU_000422_11_4_6"/>
    <dbReference type="OMA" id="NVYFGRV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="6 14" id="KW-0874">Quinone</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="15">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="17">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="16">
        <location>
            <begin position="223"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB62549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="910" mass="100665" checksum="1D1810DF57BAAF57" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DT0</accession>
    <name>ARNF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF</fullName>
            <shortName evidence="1">L-Ara4N-phosphoundecaprenol flippase subunit ArnF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">arnF</name>
        <name type="ordered locus">SDY_2454</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of ArnE and ArnF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArnF family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62525" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62525.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000523884.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404016.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DT0"/>
    <dbReference type="STRING" id="300267.SDY_2454"/>
    <dbReference type="EnsemblBacteria" id="ABB62525">
        <property type="protein sequence ID" value="ABB62525"/>
        <property type="gene ID" value="SDY_2454"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2454"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2961"/>
    <dbReference type="HOGENOM" id="CLU_1243704_0_0_6"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901505">
        <property type="term" value="F:carbohydrate derivative transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042221">
        <property type="term" value="P:response to chemical"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00538">
        <property type="entry name" value="Flippase_ArnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022832">
        <property type="entry name" value="Flippase_ArnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382019" description="Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="2"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="128" mass="14043" checksum="2FBAAB03ACB3A223" modified="2009-09-01" version="2">MGLMWGLFSVIIASVAQLSLGFAASHLPPMTHLWDFIATLLAFGLDARILLLGLLGYLLSVFCWYKTLHKLALSKAYALLSMSYVLVWIASMVLPGWGGTFSLKALLGVACIMSGLMLIFLPTTKQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DY6</accession>
    <name>Q32DY6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotide di-P-sugar epimerase or dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403960.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DY6"/>
    <dbReference type="STRING" id="300267.SDY_2395"/>
    <dbReference type="EnsemblBacteria" id="ABB62469">
        <property type="protein sequence ID" value="ABB62469"/>
        <property type="gene ID" value="SDY_2395"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2395"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2888"/>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_6"/>
    <dbReference type="OMA" id="WGPGDTQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="349" mass="39603" checksum="80F31E6104030DE0" modified="2005-12-06" version="1">MRTSFSQQQWIDMKVLVTGATSGLGRNAVEFLCQKGISVRATGRNEAMSKLLEKMGAEFVPADLTELVSSQAKVMLAGIDTLWHCSSFTSPWGTQQAFDLANVRATRRLGEWAIAWGVRNLIHISSPSLYFDYHHHRDIKEDFRPHRFANEFARSKAASEKVINMLSQANPQTRFTILRPQSLFGPHDKVFIPRLAHMMHHYGSILLPHGGSALVDMTYYENAVHAMWLASQEACDKLPSGRVYNITNGEHRTLRSIVQKLIDELNIDCRIRSVPYPMLDMIARSMERLGRKSAKEPPLTHYGVSKLNFDFTLDITRAQEELGYQPVITLDEGIEKTAAWLRDHGKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E54</accession>
    <name>Q32E54_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ycbE</name>
        <name evidence="5" type="ordered locus">SDY_2324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E54"/>
    <dbReference type="STRING" id="300267.SDY_2324"/>
    <dbReference type="EnsemblBacteria" id="ABB62401">
        <property type="protein sequence ID" value="ABB62401"/>
        <property type="gene ID" value="SDY_2324"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2324"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="EWPTALS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="172" mass="19096" checksum="B2949EE8342D7578" modified="2005-12-06" version="1">MMFQDARLLPWKSVIDNVGLGLKGQWRDAARRALAAVGLENRAGEWPTALSGGQKQRVALARALIHRPGLLLLDEPLGALDALTRLEMQDLIVSLWQEHGFTVLLVTHDVSEAVAMADRVLLIEEGKIGLDLTVDIPRPRRLGSVRLAELEAEVLQRVMQRGESETRLRKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E65</accession>
    <name>Q32E65_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403881.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E65"/>
    <dbReference type="EnsemblBacteria" id="ABB62390">
        <property type="protein sequence ID" value="ABB62390"/>
        <property type="gene ID" value="SDY_2313"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2313"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="10025" checksum="3326FAFA1FF53316" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITQFVIFVLQFILRHAIFFLSQIRFGCTYVIHKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E88</accession>
    <name>Q32E88_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E88"/>
    <dbReference type="STRING" id="300267.SDY_2290"/>
    <dbReference type="EnsemblBacteria" id="ABB62367">
        <property type="protein sequence ID" value="ABB62367"/>
        <property type="gene ID" value="SDY_2290"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2290"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_1_6"/>
    <dbReference type="OMA" id="NQAHNRK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="208" mass="23806" checksum="BE2B9B3F1F43D503" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAIGDAANLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EA4</accession>
    <name>Q32EA4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yegW</name>
        <name evidence="2" type="ordered locus">SDY_2274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000434038.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403842.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EA4"/>
    <dbReference type="SMR" id="Q32EA4"/>
    <dbReference type="STRING" id="300267.SDY_2274"/>
    <dbReference type="EnsemblBacteria" id="ABB62351">
        <property type="protein sequence ID" value="ABB62351"/>
        <property type="gene ID" value="SDY_2274"/>
    </dbReference>
    <dbReference type="GeneID" id="66674003"/>
    <dbReference type="KEGG" id="sdy:SDY_2274"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2747"/>
    <dbReference type="HOGENOM" id="CLU_063236_4_0_6"/>
    <dbReference type="OMA" id="RMTMKRA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="248" mass="28277" checksum="E4B3CD729CA7F1C8" modified="2005-12-06" version="1">MEQAHTQLIAQLNERILAADNTPLYIKFAETVKNAVRSGVLEHGNILPGERDLSQLTGVSRITVRKAMQALEEEGVVTRSRGYGTQINNIFEYSLKEARGFSQQVVLRGKKPDTLWVNKRVVKCPEEVAQQLAVEAGSDVFLLKRIRYVDEEAVSIEESWVPAHLIHDVDAIGISLYDYFRSQHIYPQRTRSRVSARMPDAEFQSHIQLDSKIPVLVIKQVALDQQQRPIEYSISHCRSDLYVFVCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EA5</accession>
    <name>Q32EA5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_2273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001278249.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403841.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EA5"/>
    <dbReference type="STRING" id="300267.SDY_2273"/>
    <dbReference type="EnsemblBacteria" id="ABB62350">
        <property type="protein sequence ID" value="ABB62350"/>
        <property type="gene ID" value="SDY_2273"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2273"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2746"/>
    <dbReference type="HOGENOM" id="CLU_027634_7_1_6"/>
    <dbReference type="OMA" id="IGGCALN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="19"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="321" mass="34393" checksum="FCD5EC3DBA5D52CB" modified="2005-12-06" version="1">MSDARLHTLLPELTSRQPVMVVGAAVIDVIADAYALPWRGCDIELKQQSVNVGGCALNIAVALKRLGIEAGNALPLGQGVWAEIIRNRMAKEGLISLIDNVEGDNGWCLALVEPDGERTFMSFSGVENQWNRQWLARLTVAPGSLLYFSGYQLTSPCGELLVEWLEKLQDVTPFIDFGPRIGDIPEALLARIMACRPLVSLNRQEAEIAAERFALSAEITTLGKQWQEKFAAPLIVRLDKEGAWYFSNNASGCIPAFPTQVVDTIGAGDSHAGGVLAGLASGLPLADAVLLGNAVASSVVGHRGGDCAPTREELLLAHKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EL5</accession>
    <name>Q32EL5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yohD</name>
        <name evidence="2" type="ordered locus">SDY_2152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403731.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EL5"/>
    <dbReference type="STRING" id="300267.SDY_2152"/>
    <dbReference type="EnsemblBacteria" id="ABB62240">
        <property type="protein sequence ID" value="ABB62240"/>
        <property type="gene ID" value="SDY_2152"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2152"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2602"/>
    <dbReference type="HOGENOM" id="CLU_044208_7_2_6"/>
    <dbReference type="OMA" id="FMYGFRI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="204" mass="22851" checksum="A813630EF7D08BF2" modified="2005-12-06" version="1">MLTGNQRETDWPMDLNTLISQYGYAALVIGSLAEGETVTLLGGVAAHQGLLKFPLVVLSVALGGMIGDQVLYLCGRRFGGKLLRRFSKHQDKIERAQKLIQRHPYLFVIGTRFMYGFRVIGPTLIGASQLPPKIFLPLNILGAFAWALIFTTIGYAGGQVIAPWLHNLDQHLKHWVWLILVVVLVVGVRWWLKRRGKKKPDNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EP6</accession>
    <name>Q32EP6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403700.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EP6"/>
    <dbReference type="STRING" id="300267.SDY_2119"/>
    <dbReference type="EnsemblBacteria" id="ABB62209">
        <property type="protein sequence ID" value="ABB62209"/>
        <property type="gene ID" value="SDY_2119"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2119"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2551"/>
    <dbReference type="HOGENOM" id="CLU_056515_0_0_6"/>
    <dbReference type="OMA" id="PRCAIGD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016913">
        <property type="entry name" value="UCP029215"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09979">
        <property type="entry name" value="DUF2213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029215">
        <property type="entry name" value="UCP029215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="290" mass="31406" checksum="E9958981A11799A3" modified="2005-12-06" version="1">MLADLIVKDESAIQLIEDGLREVSCGYDAEYEQTEPGKAEQVDITGNHVALVPKGRAGNRCAIGDRDTMANQKKNWWNRMRAAIKTGDADTMNELVESAPASVTGDEGDLPQGVNLNINLSPQQPLPDKAPEMGGDPTGDSDDDLKTLLKALLTKLERNATGDNDNKPDDNPTGDGEDNEEETTITGDSAWRAEVIVPGIDLSRKMKPTAFKREVLASADKTLVRQIVGDADIRKLPKQSVDMAFNAVSEVAKGRNTRATTGDAQRLNMGMTSIASLNKQNAEFWANRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EQ2</accession>
    <name>Q32EQ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403694.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EQ2"/>
    <dbReference type="EnsemblBacteria" id="ABB62203">
        <property type="protein sequence ID" value="ABB62203"/>
        <property type="gene ID" value="SDY_2113"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2113"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="94" mass="10333" checksum="C9861CFBA55A76E6" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITNKRYDEEIANNTTRSHAWKCSKSTAVFKAGSNAGDTTPVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ER0</accession>
    <name>RIHB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Putative pyrimidine-specific ribonucleoside hydrolase RihB</fullName>
            <ecNumber>3.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cytidine/uridine-specific hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rihB</name>
        <name type="ordered locus">SDY_2104</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>a pyrimidine ribonucleoside + H2O = a pyrimidine nucleobase + D-ribose</text>
            <dbReference type="Rhea" id="RHEA:56816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:26432"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:141014"/>
            <dbReference type="EC" id="3.2.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IUNH family. RihB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">This sequence is 42 amino acid shorter than orthologs and therefore lacks two conserved residues involved in calcium binding and active site activity. The two other residues involved in calcium binding are present but it is not known if they still bind calcium.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403686.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ER0"/>
    <dbReference type="SMR" id="Q32ER0"/>
    <dbReference type="STRING" id="300267.SDY_2104"/>
    <dbReference type="EnsemblBacteria" id="ABB62195">
        <property type="protein sequence ID" value="ABB62195"/>
        <property type="gene ID" value="SDY_2104"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2104"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2534"/>
    <dbReference type="HOGENOM" id="CLU_036838_2_0_6"/>
    <dbReference type="OMA" id="REKAHEW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050263">
        <property type="term" value="F:ribosylpyrimidine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000206828" description="Putative pyrimidine-specific ribonucleoside hydrolase RihB">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="271" mass="29164" checksum="044B86FD8E8074DD" modified="2005-12-06" version="1">MAALPINGLNVCQKLEINVPVYAGMPQPIMRQQIVADNIHGETGLDGPVFEPLTRQAESTHAVKYIIDTLMASDGDITLVPVGPLSNIAVAMRMQPAILPKIREIVLMGGAYGTGNFTPSAEFNIFADPEAARVVFTSGVPLVMMGLDLTNQTVCTPDVIARMERAGGPAGELFSDIMNFTLKTQFENYGLAGGPVHDATCIGYLINPDGIKTQDMYVEVDVNSGPCYGRTVCDELGVLGKPANTKVGITIDTDWFWGLVEECVRGYIKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ET5</accession>
    <name>Q32ET5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">flgB</name>
        <name evidence="8" type="ordered locus">SDY_2078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000884712.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403661.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ET5"/>
    <dbReference type="STRING" id="300267.SDY_2078"/>
    <dbReference type="EnsemblBacteria" id="ABB62170">
        <property type="protein sequence ID" value="ABB62170"/>
        <property type="gene ID" value="SDY_2078"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2078"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2496"/>
    <dbReference type="HOGENOM" id="CLU_125463_1_0_6"/>
    <dbReference type="OMA" id="GHMARND"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30435:SF12">
        <property type="entry name" value="PTHR30435:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01396">
        <property type="entry name" value="FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="138" mass="15298" checksum="5991B95DF8F68B73" modified="2005-12-06" version="1">MLDKLDAALRFQQEALNLRAQRQEVLAANIANADTPGYQVRDIDFASELKKVMQRGRDATSVVALMMTSTQHIPAQALTPPTAELQYRIPDQPSLDGNTVDMDRERTQFADNSLQYQMSLSALSGQIKGMMNVLQSGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EV1</accession>
    <name>FABH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="1">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="1">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabH</name>
        <name type="ordered locus">SDY_2059</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000288133.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403645.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EV1"/>
    <dbReference type="SMR" id="Q32EV1"/>
    <dbReference type="STRING" id="300267.SDY_2059"/>
    <dbReference type="EnsemblBacteria" id="ABB62154">
        <property type="protein sequence ID" value="ABB62154"/>
        <property type="gene ID" value="SDY_2059"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2059"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2474"/>
    <dbReference type="HOGENOM" id="CLU_039592_3_1_6"/>
    <dbReference type="OMA" id="WGSEGDK"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000056407" description="3-oxoacyl-[acyl-carrier-protein] synthase 3">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="1">
        <location>
            <begin position="245"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <sequence length="317" mass="33543" checksum="BF3192CFEC7023D3" modified="2005-12-06" version="1">MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSVLVRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-12" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EW6</accession>
    <name>THIK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine kinase</fullName>
            <ecNumber evidence="1">2.7.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiK</name>
        <name type="ordered locus">SDY_2044</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of thiamine to thiamine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine = ADP + H(+) + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:12012"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.89"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.89" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001116572.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403630.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EW6"/>
    <dbReference type="SMR" id="Q32EW6"/>
    <dbReference type="STRING" id="300267.SDY_2044"/>
    <dbReference type="EnsemblBacteria" id="ABB62139">
        <property type="protein sequence ID" value="ABB62139"/>
        <property type="gene ID" value="SDY_2044"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2044"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2458"/>
    <dbReference type="HOGENOM" id="CLU_055115_2_1_6"/>
    <dbReference type="OMA" id="DVHAGNI"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019165">
        <property type="term" value="F:thiamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01604">
        <property type="entry name" value="Thiamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014093">
        <property type="entry name" value="Thiamine_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02721">
        <property type="entry name" value="ycfN_thiK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000291000" description="Thiamine kinase">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01604"/>
        </source>
    </evidence>
    <sequence length="274" mass="32467" checksum="AF7058ABE60AFA73" modified="2005-12-06" version="1">MPFRSNNPITRDELLSRFFPQFHPVTTFNSGLSGGSFLIEHQGQRFVVRQPHDPDAPQSAFLRQYRALSQLPACIAPKPHLYLRDWMVVDYLPGEVKTYLPDTNELAGLLYYLHQQPRFGWRITLLPLLELYWQQSDPARRTVGWLRMLKRLRKAREPRPLRLSPLHMDVHAGNLVHSVSGLKLIDWEYAGDGDIALELAAVWVENTEQHRQLVNDYATRAKIYPAQLWRQVRRWFPWLLMLKAGWFEYRWRQTGDQQFIRLADDTWRQLLIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F23</accession>
    <name>Q32F23_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_1982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of a transport pathway that contributes to membrane integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PqiA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403573.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F23"/>
    <dbReference type="STRING" id="300267.SDY_1982"/>
    <dbReference type="EnsemblBacteria" id="ABB62082">
        <property type="protein sequence ID" value="ABB62082"/>
        <property type="gene ID" value="SDY_1982"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1982"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2392"/>
    <dbReference type="HOGENOM" id="CLU_089972_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007498">
        <property type="entry name" value="PqiA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005219">
        <property type="entry name" value="PqiA-like_Ent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04403">
        <property type="entry name" value="PqiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00155">
        <property type="entry name" value="pqiA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="166" mass="18874" checksum="9D658CDD690FA1CB" modified="2005-12-06" version="1">MVFFCVIGAPLILVSSIAYLWFGNRLGMNLRPVLLMLERLKEWVMLDIYLVGIGVASIKVQDYAHIQAGVGLFSFVALVILTTVTLSHLNVEELWERFYPQRPATRRDEKLRVCLGCHFTGYPDQRGRCPRCHIPLRLRRRHSLQKCWAALLASIVLLLPAGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F64</accession>
    <name>Q32F64_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phage shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pspE</name>
        <name evidence="5" type="ordered locus">SDY_1936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000473115.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403532.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F64"/>
    <dbReference type="STRING" id="300267.SDY_1936"/>
    <dbReference type="EnsemblBacteria" id="ABB62041">
        <property type="protein sequence ID" value="ABB62041"/>
        <property type="gene ID" value="SDY_1936"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1936"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2335"/>
    <dbReference type="HOGENOM" id="CLU_089574_15_1_6"/>
    <dbReference type="OMA" id="RSHMAMQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014323">
        <property type="entry name" value="Phageshock_PspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02981">
        <property type="entry name" value="phageshock_pspE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220694" evidence="3">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="site" description="May be important for providing the necessary conformational flexibility for enzymatic catalysis" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR614323-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR614323-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="104" mass="11501" checksum="13D0639DE060B95F" modified="2005-12-06" version="1">MFKKGLLALALVFSLPVFAAEYWIDVRVPEQYQQEHVQGAINIPLKEVKERIATAVPDKNDTVKVYCNAGRQSGQAKELLSEMGYTHVENAGGLKDIAMPKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FE9</accession>
    <name>Q32FE9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FE9"/>
    <dbReference type="STRING" id="300267.SDY_1847"/>
    <dbReference type="EnsemblBacteria" id="ABB61956">
        <property type="protein sequence ID" value="ABB61956"/>
        <property type="gene ID" value="SDY_1847"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1847"/>
    <dbReference type="HOGENOM" id="CLU_023194_19_1_6"/>
    <dbReference type="OMA" id="RFERWRP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="147"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="359" mass="39727" checksum="674B78BB6C615F21" modified="2005-12-06" version="1">MSNSHHTSMRGNDMSDNIRVGLIGYGYASKTFHAPLIAGTPGLELAVISSSDETKVKADWPTVTVVSEPKHLFNDPNIDLIVIPTPNDTHFPLAKAALETGKHVVVDKPFTVTLSQARELDALAKSLGRVLSVFHNRRWDSDFLTLKGLLAEGVLGEVAYFESHFDRFRPQVRDRWREQGGPGSGIWYDLAPHLLDQAITLFGLPVSMTVDLAQLRPGAQSTDYFHAILSYPQRRVILHGTMLAAAELARYIVHGSRGSYVKYGLDPQEERLKSGERLPQEDWGYDMRDGVLTRVEGEERVEETLLTVPGNYPAYYAAIRDALNGDGENPVPASQAIQVMELIELGIESAKHRATLCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FR9</accession>
    <name>Q32FR9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FR9"/>
    <dbReference type="STRING" id="300267.SDY_1716"/>
    <dbReference type="EnsemblBacteria" id="ABB61836">
        <property type="protein sequence ID" value="ABB61836"/>
        <property type="gene ID" value="SDY_1716"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1716"/>
    <dbReference type="HOGENOM" id="CLU_175366_1_0_6"/>
    <dbReference type="OMA" id="APVPHSM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015079">
        <property type="entry name" value="DUF1889"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037210">
        <property type="entry name" value="YoaC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08986">
        <property type="entry name" value="DUF1889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140670">
        <property type="entry name" value="SSF140670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="93" mass="10187" checksum="30CA3F6B480BB435" modified="2005-12-06" version="1">MQIKVIYSLIDNMVNFKDKNMPAVIDKALDFIGAMDVSAPTPSSMNESTAKGIFKYLKELGVPASAADITARADQEGWNPGFTEKMVGWAKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G53</accession>
    <name>Q32G53_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative oxidoreductase, Fe-S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SDY_1567</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000213028.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403193.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G53"/>
    <dbReference type="SMR" id="Q32G53"/>
    <dbReference type="STRING" id="300267.SDY_1567"/>
    <dbReference type="EnsemblBacteria" id="ABB61702">
        <property type="protein sequence ID" value="ABB61702"/>
        <property type="gene ID" value="SDY_1567"/>
    </dbReference>
    <dbReference type="GeneID" id="66674521"/>
    <dbReference type="KEGG" id="sdy:SDY_1567"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1879"/>
    <dbReference type="HOGENOM" id="CLU_043374_2_0_6"/>
    <dbReference type="OMA" id="CKYCSWS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014297">
        <property type="entry name" value="DMSO_DmsB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02951">
        <property type="entry name" value="DMSO_dmsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB61702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="205" mass="22752" checksum="B3B899744005D51C" modified="2005-12-06" version="1">MTTQYGFFIDSSRCTGCKTCELACKDFKDLGPEVSFRRIYEYAGGDWQEDNGVWHQNVFAYYLSISCNHCDDPACTKVCPSGAMHKREDGFVVVDEDVCIGCRYCHMACPYGAPQYNAEKGHMTKCDGCYSRVAEGKQPICVESCPLRALEFGPIEELRQKHGTLAAVAPLPRAHFTKPNIVIKPNANSRPTGDTTGYLANPEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GF2</accession>
    <name>Q32GF2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fermentative D-lactate dehydrogenase, NAD-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ldhA</name>
        <name evidence="7" type="ordered locus">SDY_1464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000762239.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403094.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GF2"/>
    <dbReference type="STRING" id="300267.SDY_1464"/>
    <dbReference type="EnsemblBacteria" id="ABB61603">
        <property type="protein sequence ID" value="ABB61603"/>
        <property type="gene ID" value="SDY_1464"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1464"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1744"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_1_6"/>
    <dbReference type="OMA" id="VIVTAHQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="5">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="6">
        <location>
            <begin position="110"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="329" mass="36550" checksum="8C416E07F7F483FC" modified="2005-12-06" version="1">MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHSVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESNVISLHCPLTPENYHLLNEAAFDQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GK5</accession>
    <name>Q32GK5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GK5"/>
    <dbReference type="STRING" id="300267.SDY_1406"/>
    <dbReference type="EnsemblBacteria" id="ABB61550">
        <property type="protein sequence ID" value="ABB61550"/>
        <property type="gene ID" value="SDY_1406"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1406"/>
    <dbReference type="HOGENOM" id="CLU_1668210_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="60"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="158" mass="17544" checksum="A4E4F9974AC66044" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITVYANLTEEDLDIQANSVIAAMKACDVKRLIFVLSLGIYDEVPGKFGEWNNAVIGEPLKPFRRAADAIEASGLEYTILRPAWLTDEDIIDYELTSRNEPFGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GM7</accession>
    <name>Q32GM7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Recombination protein Bet</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bet</name>
        <name evidence="1" type="ordered locus">SDY_1383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000100825.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403019.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GM7"/>
    <dbReference type="STRING" id="300267.SDY_1383"/>
    <dbReference type="EnsemblBacteria" id="ABB61528">
        <property type="protein sequence ID" value="ABB61528"/>
        <property type="gene ID" value="SDY_1383"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1383"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1643"/>
    <dbReference type="HOGENOM" id="CLU_063005_1_0_6"/>
    <dbReference type="OMA" id="EKCTCRI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010183">
        <property type="entry name" value="Phage_lambda_Bet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018330">
        <property type="entry name" value="RecT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03837">
        <property type="entry name" value="RecT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01913">
        <property type="entry name" value="bet_lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="261" mass="29774" checksum="A5757B59E6E36AE6" modified="2005-12-06" version="1">MSTALATLAGKLAERVGMDSVDPQELITTLRQTAFKGDASDAQFIALLIVANQYGLNPWTKEIYAFPDKQNGIVPVVGVDGWSRIINENQQFDGMDFEQDNESCTCRIYRKDRNHPICVTEWMDECRRAPFKTREGREITGPWQSHPKRMLRHKAMIQCARLAFGFAGIDDKDEAERIVENTAYTTERQPERDITPVNEETMSEINALLTFMEKTWDDDLLPLCSQIFRRNIYTSSELTQAEAVKVLGFLKQKVTEQKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GV8</accession>
    <name>Q32GV8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GV8"/>
    <dbReference type="EnsemblBacteria" id="ABB61447">
        <property type="protein sequence ID" value="ABB61447"/>
        <property type="gene ID" value="SDY_1300"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1300"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="9807" checksum="3C6DC46A38B92E43" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITINSFQMKRSCHAPFTSSLFLLCSRAVIKSKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H11</accession>
    <name>Q32H11_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe/B12 periplasmic-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H11"/>
    <dbReference type="STRING" id="300267.SDY_1243"/>
    <dbReference type="EnsemblBacteria" id="ABB61394">
        <property type="protein sequence ID" value="ABB61394"/>
        <property type="gene ID" value="SDY_1243"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1243"/>
    <dbReference type="HOGENOM" id="CLU_2023222_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="122" mass="13363" checksum="828040D3BA10635E" modified="2005-12-06" version="1">MSLTRRRFTQILASTLFLHHLPSFAQSVKFWASLTLPEAQNITRIVSAGAPADLLLLAVAPEKMVGFSSFDFARQALIPLPEHIRQLPRLGRLAGRASTLSLEGLMALHPDLVVDCGNTDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HB6</accession>
    <name>Q32HB6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yebE</name>
        <name evidence="2" type="ordered locus">SDY_1132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000024746.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402780.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HB6"/>
    <dbReference type="SMR" id="Q32HB6"/>
    <dbReference type="STRING" id="300267.SDY_1132"/>
    <dbReference type="EnsemblBacteria" id="ABB61289">
        <property type="protein sequence ID" value="ABB61289"/>
        <property type="gene ID" value="SDY_1132"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1132"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1334"/>
    <dbReference type="HOGENOM" id="CLU_068390_2_1_6"/>
    <dbReference type="OMA" id="RVCREER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07178">
        <property type="entry name" value="terB_like_YebE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007486">
        <property type="entry name" value="YebE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04391">
        <property type="entry name" value="DUF533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="23789" checksum="8A01DF7B236DB3BE" modified="2005-12-06" version="1">MANWLNQLQSLLGQSSSSTSSSADQGLGKLLVPGALGGLAGLLVANKSARKLLTKYGTNALLVGGGAVAGTVLWNKYKDKIRAAHQDEPQFGAQSTPLDERTERLILALVFAAKSDGHIDAKERAAIDQQLREAGVEEQGRVLIEQAIEQPLDPQRLATGVRNEEEALEIYFLSCAAIDIDHFMERSYLNALGDALKIPQDVREGIERDLEQQKRTLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HG8</accession>
    <name>Q32HG8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402728.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HG8"/>
    <dbReference type="STRING" id="300267.SDY_1074"/>
    <dbReference type="EnsemblBacteria" id="ABB61237">
        <property type="protein sequence ID" value="ABB61237"/>
        <property type="gene ID" value="SDY_1074"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1074"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1262"/>
    <dbReference type="HOGENOM" id="CLU_141534_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="134" mass="14465" checksum="D81E1486C5A06BB5" modified="2005-12-06" version="1">MLARSGKVSMATKKRSGEEINDRQILCGMGIKLRRLTAGICLVTQLVFPMAAAAQGVVNAAIQQPVPAQIAIANTNTVPYTLGALESAQSVAERFGISVAELRKLNQFRTFARGFDYVRQGDELDVPAQVSEKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HI7</accession>
    <name>DSRB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein DsrB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dsrB</name>
        <name type="ordered locus">SDY_1053</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DsrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000867217.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402709.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HI7"/>
    <dbReference type="SMR" id="Q32HI7"/>
    <dbReference type="STRING" id="300267.SDY_1053"/>
    <dbReference type="EnsemblBacteria" id="ABB61218">
        <property type="protein sequence ID" value="ABB61218"/>
        <property type="gene ID" value="SDY_1053"/>
    </dbReference>
    <dbReference type="GeneID" id="67415853"/>
    <dbReference type="KEGG" id="sdy:SDY_1053"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1230"/>
    <dbReference type="HOGENOM" id="CLU_189289_0_0_6"/>
    <dbReference type="OMA" id="IWFFNEL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01549">
        <property type="entry name" value="DsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019717">
        <property type="entry name" value="Dextransucrase_DSRB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10781">
        <property type="entry name" value="DSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000300615" description="Protein DsrB">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01549"/>
        </source>
    </evidence>
    <sequence length="62" mass="6946" checksum="0A43B2E7D64C74C5" modified="2005-12-06" version="1">MKVNDRVTVKTDGGPRRPGVVLAVEEFSEGTMYLVSLEDYPLGIWFFNEAGHQDGIFVEKAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HI9</accession>
    <name>MPGP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-3-phosphoglycerate phosphatase</fullName>
            <shortName evidence="1">MPGP</shortName>
            <ecNumber evidence="1">3.1.3.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">yedP</name>
        <name type="ordered locus">SDY_1051</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57541"/>
            <dbReference type="ChEBI" id="CHEBI:57744"/>
            <dbReference type="EC" id="3.1.3.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. MPGP family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.70" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000491523.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402707.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HI9"/>
    <dbReference type="SMR" id="Q32HI9"/>
    <dbReference type="STRING" id="300267.SDY_1051"/>
    <dbReference type="EnsemblBacteria" id="ABB61216">
        <property type="protein sequence ID" value="ABB61216"/>
        <property type="gene ID" value="SDY_1051"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1051"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1228"/>
    <dbReference type="HOGENOM" id="CLU_063016_1_0_6"/>
    <dbReference type="OMA" id="GPEGWNE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050531">
        <property type="term" value="F:mannosyl-3-phosphoglycerate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051479">
        <property type="term" value="P:mannosylglycerate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07507">
        <property type="entry name" value="HAD_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00617">
        <property type="entry name" value="MPGP_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006381">
        <property type="entry name" value="HAD-SF-IIB-MPGP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012815">
        <property type="entry name" value="MPG_Pase"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01142">
        <property type="entry name" value="C2.B.2:_Mannosyl-3-phosphoglyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01486">
        <property type="entry name" value="HAD-SF-IIB-MPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000273962" description="Mannosyl-3-phosphoglycerate phosphatase">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00617"/>
        </source>
    </evidence>
    <sequence length="271" mass="30484" checksum="3D163E0579EFBA0C" modified="2005-12-06" version="1">MFSIQQPLLVFSDLDGTLLDSHSYDWQPAAPWLTRLREANVPVILCSSKTSAEMLYLQKTLGLQGLPLIAENGAVIQLAEQWQEIDGFPRIISGISHGEISQVLNTLREKEHFKFTTFDDVDDATITEWTGLSRSQAALTQLHEASVTLIWRDSDERMAQFTARLNELGLQFMQGARFWHVLDASAGKDQAANWIIATYQQLSGKRPTTLGLGDGPNDAPLLEVMDYAVIVKGLNREGVHLHDEDPARVWRTQREGPEGWREGLDHFFSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HK8</accession>
    <name>Q32HK8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HK8"/>
    <dbReference type="EnsemblBacteria" id="ABB61197">
        <property type="protein sequence ID" value="ABB61197"/>
        <property type="gene ID" value="SDY_1032"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1032"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="70" mass="7918" checksum="1053BAC6FE43C2A3" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITKIPYTDVVLRICYLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HS9</accession>
    <name>Q32HS9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable third cytochrome oxidase, subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">appB</name>
        <name evidence="8" type="ordered locus">SDY_0954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000460805.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402617.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HS9"/>
    <dbReference type="STRING" id="300267.SDY_0954"/>
    <dbReference type="EnsemblBacteria" id="ABB61126">
        <property type="protein sequence ID" value="ABB61126"/>
        <property type="gene ID" value="SDY_0954"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0954"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1102"/>
    <dbReference type="HOGENOM" id="CLU_049294_0_0_6"/>
    <dbReference type="OMA" id="TAWAYWV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="378" mass="42454" checksum="8194A00D57770102" modified="2005-12-06" version="1">MFDYETLRFIWWLLIGVILVVFMISDGFDMGIGCLLPLVARNDDERRIVINSVGAHWEGNQVWLILAGGALFAAWPRVYAAAFSGFYVAMILVLCSLFFRPLAFDYRGKIADARWRKMWDAGLVIGSLVPPVVFGIAFGNLLLGVPFAFTPQLRVEYLGSFWQLLTPFPLLCGLLSLGMVILQGGVWLQLKTVGVIHLRSQLATKRAALLVMLCFLLAGYWLWVGIDGFVLLAQDANGPSNPLMKLVAVLPGAWMNNFVESPVLWIFPLLGFFCPLLTVMAIYRGRPGWGFLMASLMQFGVIFTTGITLFPFVMPSSVSPISSLTLWDSTSSQLTLSIMLVIVLIFLPIVLLYTLWSYYKMWGRMTTETLRRNENELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HX6</accession>
    <name>Q32HX6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic-guanylate-specific phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rtn</name>
        <name evidence="12" type="ordered locus">SDY_0903</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'-&gt;5')guanosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24902"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58754"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="3.1.4.52"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.52" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000470595.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402570.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HX6"/>
    <dbReference type="STRING" id="300267.SDY_0903"/>
    <dbReference type="EnsemblBacteria" id="ABB61079">
        <property type="protein sequence ID" value="ABB61079"/>
        <property type="gene ID" value="SDY_0903"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0903"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1044"/>
    <dbReference type="HOGENOM" id="CLU_000445_131_2_6"/>
    <dbReference type="OMA" id="FLQGYWI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0071111">
        <property type="term" value="F:cyclic-guanylate-specific phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024744">
        <property type="entry name" value="CSS-motif_dom"/>
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        <property type="entry name" value="EAL_dom"/>
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    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12792">
        <property type="entry name" value="CSS-motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0973">c-di-GMP</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="11">
        <location>
            <begin position="261"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB61079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="518" mass="58518" checksum="24CA55B8CBC47A61" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I08</accession>
    <name>Q32I08_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferredoxin-type protein NapF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">napF</name>
        <name evidence="8" type="ordered locus">SDY_0870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the cytoplasmic NapA precursor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NapF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402538.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I08"/>
    <dbReference type="STRING" id="300267.SDY_0870"/>
    <dbReference type="EnsemblBacteria" id="ABB61047">
        <property type="protein sequence ID" value="ABB61047"/>
        <property type="gene ID" value="SDY_0870"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0870"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1005"/>
    <dbReference type="HOGENOM" id="CLU_077329_2_1_6"/>
    <dbReference type="OMA" id="YQGIWCQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10564">
        <property type="entry name" value="NapF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02201">
        <property type="entry name" value="NapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004496">
        <property type="entry name" value="NapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24960:SF46">
        <property type="entry name" value="PTHR24960:SF46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00402">
        <property type="entry name" value="napF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="164" mass="18051" checksum="28396E709FCF9766" modified="2005-12-06" version="1">MKIDASRRGILTGRWRKASNGIRPPWSGDESHFLTHCTRCDACINACENNSLQRGTGGYPSVNFKNNECSFCYACAQACPESLFSPRHTRAWDLQFTIGDACLAYQSVECRRCQDSCEPMAIIFRPTLSGIYQPQLNSQLCNGCGACAASCPVSAITAEYLHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I19</accession>
    <name>Q32I19_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphotransferase RcsD</fullName>
            <ecNumber evidence="3">2.7.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Phosphotransfer intermediate RcsD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yojN</name>
        <name evidence="3" type="synonym">rcsD</name>
        <name evidence="7" type="ordered locus">SDY_0858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RcsC and RcsB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylated by RcsC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RcsD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001249153.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402527.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I19"/>
    <dbReference type="STRING" id="300267.SDY_0858"/>
    <dbReference type="EnsemblBacteria" id="ABB61036">
        <property type="protein sequence ID" value="ABB61036"/>
        <property type="gene ID" value="SDY_0858"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0858"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.992"/>
    <dbReference type="HOGENOM" id="CLU_009611_0_0_6"/>
    <dbReference type="OMA" id="TWRYATW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016774">
        <property type="term" value="F:phosphotransferase activity, carboxyl group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00980">
        <property type="entry name" value="RcsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030861">
        <property type="entry name" value="Ptransferase_RcsD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032306">
        <property type="entry name" value="RcsD_ABL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038616">
        <property type="entry name" value="RcsD_ABL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16359">
        <property type="entry name" value="RcsD_ABL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="468"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="6">
        <location>
            <begin position="803"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3 4">
        <location>
            <position position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="890" mass="100451" checksum="FDE98602BA8D6B4F" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I23</accession>
    <name>Q32I23_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I23"/>
    <dbReference type="STRING" id="300267.SDY_0854"/>
    <dbReference type="EnsemblBacteria" id="ABB61032">
        <property type="protein sequence ID" value="ABB61032"/>
        <property type="gene ID" value="SDY_0854"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0854"/>
    <dbReference type="HOGENOM" id="CLU_1537748_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221008" evidence="1">
        <location>
            <begin position="20"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="174" mass="19077" checksum="2C4CF4D4F5E937FB" modified="2005-12-06" version="1">MRKIFLPLLLVALSPVAHSEGVQEVEIDAPLSGWHPAEGEDASFSQSINYPASSVNMADDQNISAQIRGKIKNYAAAGKVQQGRLVVNGASMPQRIESDGSFARPYIFTEGSNSVQVISPDGQSRQKMQFYSTRVQERFVHVYGWFSRGIRTIPTSIFTLSRPMANTPGTVTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IE0</accession>
    <name>Q32IE0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402406.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IE0"/>
    <dbReference type="STRING" id="300267.SDY_0733"/>
    <dbReference type="EnsemblBacteria" id="ABB60917">
        <property type="protein sequence ID" value="ABB60917"/>
        <property type="gene ID" value="SDY_0733"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0733"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.847"/>
    <dbReference type="HOGENOM" id="CLU_2221440_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024459">
        <property type="entry name" value="DUF1073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06381">
        <property type="entry name" value="DUF1073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="106" mass="12091" checksum="437B570E97D371B6" modified="2005-12-06" version="1">MARNKQALRRTVQATADGYENFIARVGMQTPNQHSASTYRANFTSRNRMLVEWSYRSSWIIGEAVDAIPDDMTRKGIRITSEIDAKDRGILESQLDELQIWDALNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IG3</accession>
    <name>Q32IG3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Multidrug efflux pump accessory protein AcrZ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AcrAB-TolC multidrug efflux pump accessory protein AcrZ</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acridine resistance protein Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acrZ</name>
        <name evidence="2" type="ordered locus">SDY_0709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts directly with AcrB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AcrZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000891515.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402383.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IG3"/>
    <dbReference type="SMR" id="Q32IG3"/>
    <dbReference type="STRING" id="300267.SDY_0709"/>
    <dbReference type="EnsemblBacteria" id="ABB60894">
        <property type="protein sequence ID" value="ABB60894"/>
        <property type="gene ID" value="SDY_0709"/>
    </dbReference>
    <dbReference type="GeneID" id="67413801"/>
    <dbReference type="KEGG" id="sdy:SDY_0709"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.820"/>
    <dbReference type="HOGENOM" id="CLU_196028_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01484">
        <property type="entry name" value="AcrZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019702">
        <property type="entry name" value="AcrZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10766">
        <property type="entry name" value="AcrZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="49" mass="5300" checksum="1B1185D27F1F37F7" modified="2005-12-06" version="1">MLELLKSLVFAVIMVPVVMAIILGLIYGLGEVFNIFSGVGKKDQPGQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IG5</accession>
    <name>Q32IG5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding component of molybdate transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">modF</name>
        <name evidence="5" type="ordered locus">SDY_0707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000096866.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402381.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IG5"/>
    <dbReference type="STRING" id="300267.SDY_0707"/>
    <dbReference type="EnsemblBacteria" id="ABB60892">
        <property type="protein sequence ID" value="ABB60892"/>
        <property type="gene ID" value="SDY_0707"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0707"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.818"/>
    <dbReference type="HOGENOM" id="CLU_000604_45_0_6"/>
    <dbReference type="OMA" id="TIWDIKQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="261"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="293"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="490" mass="54550" checksum="9A4D2D00D3596FAC" modified="2005-12-06" version="1">MSSLQILQGTFRLSDTKTLQLPQLTLNAGDSWAFVGSNGSGKSALARALAGELPLLKGERQSQFSHITRLSFEQLQKLVSDEWQRNNTDMLGPGEDDTGRTTAEIIQDEVKDAPRCMQLAQQFGITALLDRRFKYLSTGETRKTLLCQALMSEPDLLILDEPFDGLDVASRQQLAERLASLHQSGITLVLVLNRFDEIPEFVQFAGVLADCTLAETGAKEELLQQALVAQLAHSEQLEGVQLPEPDEPSARHALPANEPRIVLNNGVVSYNDRPILNNLSWQVNPGEHWQIVGPNGAGKSTLLSLITGDHPQGYSNDLTLFGRRRGSGETIWDIKKHIGYVSSSLHLDYRVSTTVRNVILSGYFDSIGIYQAVSDRQQKLVQQWLDILGIDKRTADAPFHSLSWGQQRLALIVRALVKHPTLLILDEPLQGLDPLNRQLIRRFVDVLISEGETQLLFVSHHAEDAPACITHRLEFVPDGGLYRYVLTKIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IK3</accession>
    <name>SUCC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="1">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="1">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sucC</name>
        <name type="ordered locus">SDY_0666</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001048585.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402343.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IK3"/>
    <dbReference type="SMR" id="Q32IK3"/>
    <dbReference type="STRING" id="300267.SDY_0666"/>
    <dbReference type="EnsemblBacteria" id="ABB60854">
        <property type="protein sequence ID" value="ABB60854"/>
        <property type="gene ID" value="SDY_0666"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0666"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.777"/>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_6"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="chain" id="PRO_1000082233" description="Succinate--CoA ligase [ADP-forming] subunit beta">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="1">
        <location>
            <begin position="9"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="321"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <sequence length="388" mass="41351" checksum="F86E384D89E9C881" modified="2005-12-06" version="1">MNLHEYQAKQLFARYGLPAPVGYACTTPREAEEAASKIGAGPWGVKCQVHAGGRGKAGGVKVVNSKEDIRAFAENWLGKRLVTYQTDANGQPVNQILVEAATDIAKELYLGAVVDRSSRRVVFMASTEGGVEIEKVAEETPHLIHKVALDPLTGPMPYQGRELAFKLGLEGKLVQQFTKIFMGLATIFLERDLALIEINPLVITKQGDLICLDGKLGADGNALFRQPDLREMRDQSQEDPREAQAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGEPANFLDVGGGATKERVTEAFKIILSDDKVKAVLVNIFGGIVRCDLIADGIIGAVAEVGVNVPVVVRLEGNNAELGAKKLADSGLNIIAAKGLTDAAQQVVAAVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IQ6</accession>
    <name>Q32IQ6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthetase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB</name>
        <name evidence="9" type="ordered locus">SDY_0608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000337072.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402290.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IQ6"/>
    <dbReference type="STRING" id="300267.SDY_0608"/>
    <dbReference type="EnsemblBacteria" id="ABB60801">
        <property type="protein sequence ID" value="ABB60801"/>
        <property type="gene ID" value="SDY_0608"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0608"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.703"/>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_6"/>
    <dbReference type="OMA" id="DWSGIYS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="554" mass="62600" checksum="615B4C9D55F8E323" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IS0</accession>
    <name>Q32IS0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402276.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IS0"/>
    <dbReference type="STRING" id="300267.SDY_0587"/>
    <dbReference type="EnsemblBacteria" id="ABB60787">
        <property type="protein sequence ID" value="ABB60787"/>
        <property type="gene ID" value="SDY_0587"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0587"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.687"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_3_6"/>
    <dbReference type="OMA" id="DNAMAET"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="106"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32358" checksum="AB9050E2E22CDE10" modified="2005-12-06" version="1">MVTLCHVFGVHRSSYRYWKNRPEKPDGRRAVLRSQVLELHGISHGSAGARSIATMATRRGYQMGRWLAGRLMKELGLVSCQQPTRRYKRGGHEHVAIPNYLERQFAVTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKPGGVMFHSDQGSHYTSRQFRQLLWRYQIRQSMSRRGNCWDNSPMERFFRSLKNEWMPVVGYVSFSEAAHAITDYIVGYYSALRPHEYNGGLPPNESENRYWKNSNSVASFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IU7</accession>
    <name>Q32IU7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rlpA</name>
        <name evidence="7" type="ordered locus">SDY_0555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001231434.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402249.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IU7"/>
    <dbReference type="STRING" id="300267.SDY_0555"/>
    <dbReference type="EnsemblBacteria" id="ABB60760">
        <property type="protein sequence ID" value="ABB60760"/>
        <property type="gene ID" value="SDY_0555"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0555"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.657"/>
    <dbReference type="HOGENOM" id="CLU_042923_3_0_6"/>
    <dbReference type="OMA" id="PFYSDRI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPOR" evidence="6">
        <location>
            <begin position="285"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="362" mass="37498" checksum="D9B33EF0F04EEDF9" modified="2005-12-06" version="1">MRKQWLGICIAAGMLAACTSDDGQQQTVSVPQPAVCNGPIVEISGADPRFEPLNATANQDYQRDGKSYKIVQDPSRFSQAGLAAIYDAEPGSNLTASGEAFEPTQLTAAHPTLPIPSYARITNLANGRMIVVRINDRGPYGNDRVISLSRAAADRLNTSNNTKVRIDPIIVAQDGSLSGPGMACTTVAKQTYALPAPPDLSGGAGTTSVSGPQGDILPVSNSTLKSEDPTGAPVTSSGFLGAPTTLAPGVLEGSEPTPAPQPVVTAPSTTPATSPAMVAPQAASQSASGNFMVQVGAVSDQARAQQYQQQLGQKFGVPGRVTQNGAVWRIQLGPFASKAEASTLQQRLQTEAQLQSFITTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IW0</accession>
    <name>Q32IW0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybdQ</name>
        <name evidence="3" type="ordered locus">SDY_0542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000278505.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402236.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IW0"/>
    <dbReference type="SMR" id="Q32IW0"/>
    <dbReference type="STRING" id="300267.SDY_0542"/>
    <dbReference type="EnsemblBacteria" id="ABB60747">
        <property type="protein sequence ID" value="ABB60747"/>
        <property type="gene ID" value="SDY_0542"/>
    </dbReference>
    <dbReference type="GeneID" id="66671117"/>
    <dbReference type="KEGG" id="sdy:SDY_0542"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.642"/>
    <dbReference type="HOGENOM" id="CLU_049301_12_0_6"/>
    <dbReference type="OMA" id="RRPNITT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="142" mass="15936" checksum="F135F7F6EE910532" modified="2005-12-06" version="1">MYKTIIMPVDVFEMELSDKAVRHAEFLAQDDGVIHLLHVLPGSASLSLHRFAADVRRFEEHLQHEAEERLQTMVSHFTIDPSRIKQHVRFGSVRDEVNELAEELGADVVVIGSRNPSISTHLLGSNASSVIRHANLPVLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IY9</accession>
    <name>Q32IY9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enterobactin synthase component D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">4'-phosphopantetheinyl transferase EntD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Enterochelin synthase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">entD</name>
        <name evidence="15" type="ordered locus">SDY_0511</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo-domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>apo-[aryl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]</text>
            <dbReference type="Rhea" id="RHEA:48404"/>
            <dbReference type="Rhea" id="RHEA-COMP:15903"/>
            <dbReference type="Rhea" id="RHEA-COMP:17557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>apo-[peptidyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]</text>
            <dbReference type="Rhea" id="RHEA:46228"/>
            <dbReference type="Rhea" id="RHEA-COMP:11479"/>
            <dbReference type="Rhea" id="RHEA-COMP:11480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis; enterobactin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P-Pant transferase superfamily. EntD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402207.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IY9"/>
    <dbReference type="STRING" id="300267.SDY_0511"/>
    <dbReference type="EnsemblBacteria" id="ABB60718">
        <property type="protein sequence ID" value="ABB60718"/>
        <property type="gene ID" value="SDY_0511"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0511"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.603"/>
    <dbReference type="HOGENOM" id="CLU_075076_1_0_6"/>
    <dbReference type="OMA" id="WFGSISH"/>
    <dbReference type="UniPathway" id="UPA00017"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009366">
        <property type="term" value="C:enterobactin synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009239">
        <property type="term" value="P:enterobactin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041354">
        <property type="entry name" value="4PPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003542">
        <property type="entry name" value="Enbac_synth_compD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38096">
        <property type="entry name" value="PTHR38096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17837">
        <property type="entry name" value="4PPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01399">
        <property type="entry name" value="ENTSNTHTASED"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0259">Enterobactin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4PPT_N" evidence="14">
        <location>
            <begin position="40"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="ACPS" evidence="13">
        <location>
            <begin position="106"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB60718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="209" mass="23487" checksum="CFF0A45C636C6F6B" modified="2005-12-06" version="1">MVDMKTTHTALPFAGHTLHFVEFDPANFCEQDLLWLPHYAQLQHAGRKRKTEHLAGRIAAVYALREYGYKCVPAIGELRQPVWPAEVYGSISHCGATALAVVSRQPIGVDIEEIFSPQTATELTDNIITPAEHERLADCGLAFSLALTLAFSAKESAFKASEIQTDAGFLDYQIISWNKQQVIIHRENEMFAVHWQIKEKIVITLCQHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J35</accession>
    <name>Q32J35_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J35"/>
    <dbReference type="EnsemblBacteria" id="ABB60672">
        <property type="protein sequence ID" value="ABB60672"/>
        <property type="gene ID" value="SDY_0464"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0464"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="FHGEGHR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32049" checksum="D59F6D2F8FB90102" modified="2005-12-06" version="1">MSRAQLRVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J79</accession>
    <name>Q32J79_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cytoplasmic membrane export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_0417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402117.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J79"/>
    <dbReference type="STRING" id="300267.SDY_0417"/>
    <dbReference type="EnsemblBacteria" id="ABB60628">
        <property type="protein sequence ID" value="ABB60628"/>
        <property type="gene ID" value="SDY_0417"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0417"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.496"/>
    <dbReference type="HOGENOM" id="CLU_000604_95_6_6"/>
    <dbReference type="OMA" id="IFTHTAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="262"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="297"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="508" mass="56252" checksum="D942C408D0D3AC55" modified="2005-12-06" version="1">MRMVRTHLSDVIGKRADLRISDRVFGHALRLKNNVRSKSTGSFISQIRELESVRELITSTTIGAVADLPFFLLFVFILWMIGGWLVLVVLLALPLLVLPGLLVQRPLARLANEGMRESAVHNATLVEAVQSIEDIKLLRAEQRFQNQWNHTNDVASSISMKQRFLTGLLLTWTQEVQSIVYVVVLLVGCFMVMNGDMTTGALVGTTILASRTIAPLSQISGVLSRWQQAKVARNGLDELMKRPVDQPEHGKLVHKAVLHGNYQFSNAIFYYDEEEKIADVAIGKLNIQAGEKIAILGRNGAGKSTLLQMLAGMRIAQQGQVLLDNISIGQLDPADLRRDMGLLSQTGRLFFGSLRENLTMGMPEASDEDIERALILSGALPFVQKQKNGLNYMIQEGGFGLSGGQRQTLLLARLLISQPNIVLLDEPSASLDEMAEAYLIEQLKQWIGHRTLVIATHRTAMLQLVDRIIVMDQGRIVMDGAKEAILREQGEPTARRVVLQEKNKGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JB5</accession>
    <name>Q32JB5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional repressor of the lac operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lacI</name>
        <name evidence="5" type="ordered locus">SDY_0379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378570.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402081.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JB5"/>
    <dbReference type="STRING" id="300267.SDY_0379"/>
    <dbReference type="EnsemblBacteria" id="ABB60592">
        <property type="protein sequence ID" value="ABB60592"/>
        <property type="gene ID" value="SDY_0379"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0379"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.450"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_4_6"/>
    <dbReference type="OMA" id="ADPFYGP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="360" mass="38502" checksum="4E062A278A3599E8" modified="2005-12-06" version="1">MKPVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAMAELNYIPNRVAQQLAGKQSLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVERSGVEACKAAVHNLLAQRVSGLIINYPLDDQDAIAVEAACANVPALFLDVSDQTPINSIIFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNGGIVPTAMLVANDQMALGAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSVDRLLQLSQGQAVKGNQLLPVSLVKRKTTLAPKTQTASPRALADSLMQLARQVSRLESGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JD2</accession>
    <name>Q32JD2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Induced by phosphate starvation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">psiF</name>
        <name evidence="2" type="ordered locus">SDY_0360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402064.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JD2"/>
    <dbReference type="STRING" id="300267.SDY_0360"/>
    <dbReference type="EnsemblBacteria" id="ABB60575">
        <property type="protein sequence ID" value="ABB60575"/>
        <property type="gene ID" value="SDY_0360"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0360"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.422"/>
    <dbReference type="HOGENOM" id="CLU_129289_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011690">
        <property type="entry name" value="P_starv_induced_PsiF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07769">
        <property type="entry name" value="PsiF_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="10024" checksum="C53C68EC2B743B6C" modified="2005-12-06" version="1">MKRDGAMKITLLVTLLFGLVFLTTVGAAERTLTPQQQRMTSCNQQATAQALKGDARKTYMSDCLKNSKSAPGEKSLTPQQQKMRECNNQAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JE7</accession>
    <name>RDGC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Recombination-associated protein RdgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rdgC</name>
        <name type="ordered locus">SDY_0344</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdgC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001298537.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402049.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JE7"/>
    <dbReference type="SMR" id="Q32JE7"/>
    <dbReference type="STRING" id="300267.SDY_0344"/>
    <dbReference type="EnsemblBacteria" id="ABB60559">
        <property type="protein sequence ID" value="ABB60559"/>
        <property type="gene ID" value="SDY_0344"/>
    </dbReference>
    <dbReference type="GeneID" id="66671307"/>
    <dbReference type="KEGG" id="sdy:SDY_0344"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.403"/>
    <dbReference type="HOGENOM" id="CLU_052038_1_1_6"/>
    <dbReference type="OMA" id="RFDADFT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00194">
        <property type="entry name" value="RdgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007476">
        <property type="entry name" value="RdgC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38103">
        <property type="entry name" value="PTHR38103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04381">
        <property type="entry name" value="RdgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000021239" description="Recombination-associated protein RdgC">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00194"/>
        </source>
    </evidence>
    <sequence length="303" mass="33993" checksum="1825EB06B6A67005" modified="2005-12-06" version="1">MLWFKNLMVYRLSREISLRAEEMEKQLASMAFTPCGSQDMAKMGWVPPMGSHSDALTHVANGQIVICARKEEKILPSPVIKQALEAKIAKLEAEQARKLKKTEKDSLKDEVLHSLLPRAFSRFSQTMMWIDTVNGLIMVDCASAKKAEDTLALLRKSLGSLPVVPLSMENPIELTLTEWVRSGSAAQGFQLLDEAELKSLLEDGGVIRAKKQDLTSEEITNHIEAGKVVTKLALDWQQRIQFVMCDDGSLKRLKFCDELRDQNEDIDREDFAQRFDADFILMTGELAALIQNLIEGLGGEAQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JH0</accession>
    <name>NUSB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nusB</name>
        <name type="ordered locus">SDY_0318</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000801125.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402026.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JH0"/>
    <dbReference type="SMR" id="Q32JH0"/>
    <dbReference type="STRING" id="300267.SDY_0318"/>
    <dbReference type="EnsemblBacteria" id="ABB60537">
        <property type="protein sequence ID" value="ABB60537"/>
        <property type="gene ID" value="SDY_0318"/>
    </dbReference>
    <dbReference type="GeneID" id="67416509"/>
    <dbReference type="KEGG" id="sdy:SDY_0318"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.367"/>
    <dbReference type="HOGENOM" id="CLU_087843_4_1_6"/>
    <dbReference type="OMA" id="DRMPVVD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0889">Transcription antitermination</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000265593" description="Transcription antitermination protein NusB">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <sequence length="139" mass="15689" checksum="0BB912103061243B" modified="2005-12-06" version="1">MKPAARRRARECAVQALYSWQLSQNDIADVEYQFLAEQDVKDVDVLYFRELLAGVATNTAYLDGLMKPYLSRLLEELGQVEKAVLRIALYELSKRSDVPYKVAINEAIELAKSFGAEDSHKFVNGVLDKAAPVIRPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JI8</accession>
    <name>Q32JI8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulates beta-lactamase synthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ampG</name>
        <name evidence="8" type="ordered locus">SDY_0300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000098430.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402008.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JI8"/>
    <dbReference type="STRING" id="300267.SDY_0300"/>
    <dbReference type="EnsemblBacteria" id="ABB60519">
        <property type="protein sequence ID" value="ABB60519"/>
        <property type="gene ID" value="SDY_0300"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0300"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.345"/>
    <dbReference type="HOGENOM" id="CLU_029352_1_0_6"/>
    <dbReference type="OMA" id="ANPFYVD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="PTHR12778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="13"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="491" mass="53259" checksum="6B0D7F7A838CCA9C" modified="2005-12-06" version="1">MSSQYLRIFQQPRSAILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFFGRRRGWLLATQILLLVAIAAMGFLEPGTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADKWLGWQGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNKTLGLLATIVGALYGGILMQRLSLFRALLIFGILQGASNAGYWLLSITDKHLYSMGAAVFFENLCGGMGTSAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWSTFYLFSVAAAVPGLILLLVCRQTLEYTRVNDNFISRTAYPAGYAFAMWTLAAGVSLLAVWLLLLTMEALDLTHFSFLPALLEVGVLVALSGVVLGGLLDYLALRKTHLT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JJ3</accession>
    <name>CLPP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="1">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpP</name>
        <name type="ordered locus">SDY_0295</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. Component of the ClpAP and ClpXP complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000122253.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402003.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JJ3"/>
    <dbReference type="SMR" id="Q32JJ3"/>
    <dbReference type="STRING" id="300267.SDY_0295"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="ABB60514">
        <property type="protein sequence ID" value="ABB60514"/>
        <property type="gene ID" value="SDY_0295"/>
    </dbReference>
    <dbReference type="GeneID" id="67416488"/>
    <dbReference type="KEGG" id="sdy:SDY_0295"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.340"/>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_6"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000226468" description="ATP-dependent Clp protease proteolytic subunit">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <sequence length="207" mass="23187" checksum="A7843D036C8CB3C2" modified="2005-12-06" version="1">MSYSGERDNFAPHMALVPMVIEQTSRGERSFDIYSRLLKERVIFLTGQVEDHMANLIVAQMLFLEAENPEKDIYLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQAASMGAFLLTAGAKGKRFCLPNSRVMIHQPLGGYQGQATDIEIHAREILKVKGRMNELMALHTGQSLEQIERDTERDRFLSAPEAVEYGLVDSILTHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JM2</accession>
    <name>Q32JM2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybcH</name>
        <name evidence="2" type="ordered locus">SDY_0264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JM2"/>
    <dbReference type="STRING" id="300267.SDY_0264"/>
    <dbReference type="EnsemblBacteria" id="ABB60485">
        <property type="protein sequence ID" value="ABB60485"/>
        <property type="gene ID" value="SDY_0264"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0264"/>
    <dbReference type="HOGENOM" id="CLU_110638_0_0_6"/>
    <dbReference type="OMA" id="LGLYMDP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027849">
        <property type="entry name" value="DUF4434"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14488">
        <property type="entry name" value="DUF4434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221140" evidence="1">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="197" mass="22344" checksum="73037C3C3EE15978" modified="2005-12-06" version="1">MRKFIFVLLTLLLVSPFSFAMKGIIWQPQNRDSQVSDTQWQGLMSQLRLQGFDTLVLQWTRYGDAFTQPEQRTLLFKCAAAAQQAGLKLIVGLNADPEFFMHQKQSSAALESYLNRLLAADLQQARLWSAAPGITPDGWYISAEIDDLNWRSEAARQPLLTWLNNEQRLISDVSAKPVYISSFFAGNMSPDGYHQLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K55</accession>
    <name>FIXB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein FixB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fixB</name>
        <name type="ordered locus">SDY_0064</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for anaerobic carnitine reduction. May bring reductant to CaiA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine metabolism; carnitine metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of FixA and FixB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001091506.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401791.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K55"/>
    <dbReference type="SMR" id="Q32K55"/>
    <dbReference type="STRING" id="300267.SDY_0064"/>
    <dbReference type="EnsemblBacteria" id="ABB60302">
        <property type="protein sequence ID" value="ABB60302"/>
        <property type="gene ID" value="SDY_0064"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0064"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.72"/>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_6"/>
    <dbReference type="OMA" id="RYVFGNK"/>
    <dbReference type="UniPathway" id="UPA00117"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01056">
        <property type="entry name" value="FixB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023461">
        <property type="entry name" value="FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000300966" description="Protein FixB">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01056"/>
        </source>
    </evidence>
    <sequence length="313" mass="33543" checksum="1DFDBBD7FFD368CD" modified="2005-12-06" version="1">MNTFSQVWVFSDTPSRLPELMNGAQALANQINTFVLNDADGAQAIQLGANHVWKLNGKPDDRMIEDYASVMADTIRQHGADGLVLLPNTRRGKLLAAKLGYRLKAAVSNDASTVSVQDGKATVKHMVYGGLAIGEERIATPYAVLTISSGTFDAAQPDASRTGETHTVEWQAPAVAITRTATQARQSNSVDLDKARLVVSVGRGIGSKENIALAEQLCKAIGAELACSRPVAENEKWMEHERYVGISNLMLKPELYLAVGISGQIQHMVGANASQTIFAINKDKNAPIFQYADYGIVGDAVKILPALTAALAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K66</accession>
    <name>DAPB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="1">HTPA reductase</shortName>
            <ecNumber evidence="1">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapB</name>
        <name type="ordered locus">SDY_0053</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000543572.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401780.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K66"/>
    <dbReference type="SMR" id="Q32K66"/>
    <dbReference type="STRING" id="300267.SDY_0053"/>
    <dbReference type="EnsemblBacteria" id="ABB60291">
        <property type="protein sequence ID" value="ABB60291"/>
        <property type="gene ID" value="SDY_0053"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0053"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.57"/>
    <dbReference type="HOGENOM" id="CLU_047479_2_1_6"/>
    <dbReference type="OMA" id="HHPNKAD"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000228387" description="4-hydroxy-tetrahydrodipicolinate reductase">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="169"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="273" mass="28778" checksum="3DC029F8E05AA7D7" modified="2005-12-06" version="1">MHDANIRVAIAGAGGRMGRQLIQAALALEGVQLGAALEREGASLLGSDAGELAGAGKTGVTVQSSLDAIKDDFDVFIDFTRPEGTLNHLAFCRQHGKGMVIGTTGFDEAGKQAIRDAAADIAIVFAANFSVGVNVMLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIAHALDKDLKDCAVYSREGHTGERVPGTIGFATVRAGDIVGEHTAMFADIGERLEITHKASSRMTFANGAVRSALWLSGKESGLFDMRDVLDLHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K92</accession>
    <name>Q32K92_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0231 protein YacL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">yacL</name>
        <name evidence="3" type="ordered locus">SDY_0026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0231 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K92"/>
    <dbReference type="STRING" id="300267.SDY_0026"/>
    <dbReference type="EnsemblBacteria" id="ABB60266">
        <property type="protein sequence ID" value="ABB60266"/>
        <property type="gene ID" value="SDY_0026"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0026"/>
    <dbReference type="HOGENOM" id="CLU_139226_0_0_6"/>
    <dbReference type="OMA" id="FSMDHEA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01053">
        <property type="entry name" value="UPF0231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008249">
        <property type="entry name" value="UPF0231"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06062">
        <property type="entry name" value="UPF0231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006287">
        <property type="entry name" value="UCP006287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="136" mass="15600" checksum="9FD0494E069DEED5" modified="2005-12-06" version="1">MAQCDFGALPGAEEHTMDYEFLRDITGVVKVRMSMGHEVVGHWFNEEVKENLALLDEVEQAAHALKGSERSWQRAGHEYTLWMDGEEVMVRANQLEFAGDEMEEGMNYYDEESLSLCGVEDFLQVVAAYRNFVQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K98</accession>
    <name>Q32K98_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401748.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K98"/>
    <dbReference type="EnsemblBacteria" id="ABB60260">
        <property type="protein sequence ID" value="ABB60260"/>
        <property type="gene ID" value="SDY_0020"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0020"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.21"/>
    <dbReference type="HOGENOM" id="CLU_075511_1_0_6"/>
    <dbReference type="OMA" id="CAVTNVG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="175" mass="19915" checksum="46A4C5A9FE2718B7" modified="2005-12-06" version="1">MLLEIEVSSCTGNNTNCNSVRFNFNLNTILQVNLMTCGFEDQSIDTGRFVLSRINNENYQFHHIRFDCIQGEQGELVFEPSDVEYYFEPVTIQEAGTSILKNELENSEDGAGQIGFQLSNDGTNEIQYGKSNYYSFQHPHEGSNQIPLFIRPRTYGNNVSSGQIMSRVKIVVMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Q7</accession>
    <name>Q326Q7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spa13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spa13</name>
        <name evidence="1" type="ordered locus">SDY_P188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406189.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Q7"/>
    <dbReference type="EnsemblBacteria" id="ABB64701">
        <property type="protein sequence ID" value="ABB64701"/>
        <property type="gene ID" value="SDY_P188"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P188"/>
    <dbReference type="HOGENOM" id="CLU_2371225_0_0_6"/>
    <dbReference type="OMA" id="MEPVGAQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="95" mass="11136" checksum="9F885C4CB10B007C" modified="2005-12-06" version="1">MEPVGAQSVSQLFNTRRKIAIVKKHIIQYQSERIILKGRIEEIQKDIDEANASKRKLLHKESKICKRISLIKRNNFAKQLILDELSQEDMKHGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q326T2</accession>
    <name>Q326T2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IpaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ipaA</name>
        <name evidence="8" type="ordered locus">SDY_P163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Sd197</strain>
            <plasmid evidence="9">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SipA/IpaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011379000.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406164.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326T2"/>
    <dbReference type="EnsemblBacteria" id="ABB64676">
        <property type="protein sequence ID" value="ABB64676"/>
        <property type="gene ID" value="SDY_P163"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P163"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5722"/>
    <dbReference type="HOGENOM" id="CLU_432046_0_0_6"/>
    <dbReference type="OMA" id="LQTDFFS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023225">
        <property type="entry name" value="SipA_chaperone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015138">
        <property type="entry name" value="SipA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040658">
        <property type="entry name" value="SipA_VBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09052">
        <property type="entry name" value="SipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17985">
        <property type="entry name" value="SipA_VBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140746">
        <property type="entry name" value="SSF140746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="SipA" evidence="7">
        <location>
            <begin position="49"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="633" mass="70208" checksum="DC54C393AF27F9C4" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q327E9</accession>
    <name>Q327E9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OspE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ospE1</name>
        <name evidence="1" type="ordered locus">SDY_P046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000957712.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406047.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327E9"/>
    <dbReference type="EnsemblBacteria" id="ABB64559">
        <property type="protein sequence ID" value="ABB64559"/>
        <property type="gene ID" value="SDY_P046"/>
    </dbReference>
    <dbReference type="GeneID" id="58461127"/>
    <dbReference type="KEGG" id="sdy:SDY_P046"/>
    <dbReference type="HOGENOM" id="CLU_2467300_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="88" mass="10015" checksum="363E47CFDDCF5F5B" modified="2005-12-06" version="1">MLTQTIFPCLPQKQENIILEVSNPVLLSSTVTTDGYTVFNKKAAIYELQIPAANRTKTLKFTATEMQWLTKINEAGIDEKQSQRYSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q327G5</accession>
    <name>Q327G5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS100 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406031.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327G5"/>
    <dbReference type="EnsemblBacteria" id="ABB64543">
        <property type="protein sequence ID" value="ABB64543"/>
        <property type="gene ID" value="SDY_P030"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P030"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5567"/>
    <dbReference type="HOGENOM" id="CLU_062999_1_0_6"/>
    <dbReference type="OMA" id="AHIINIR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="62"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="213" mass="24173" checksum="7C1131D0C22D4FA3" modified="2005-12-06" version="1">MDFLEHLLHEEKLARHQRKQAMYTRMAAFPAVKTFEEYDFTFATGAPQKQLQSLRSLSFIERNENIVLLGPSGVGKTHLAIAMGYEAVRAGIKVRFTTAADLLLQLSTAQRQGRYKTTLQRGVMAPRLLIIDEIGYLPFSQEEAKLFFQVIAKRYEKSAMILTSNLPFGQWDQTFAGDAALTSAMLDRTYTTHMSFKSKEKAIDSDRNERPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q327W1</accession>
    <name>Q327W1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tyrB</name>
        <name evidence="6" type="ordered locus">SDY_4520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000486959.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405885.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327W1"/>
    <dbReference type="STRING" id="300267.SDY_4520"/>
    <dbReference type="EnsemblBacteria" id="ABB64394">
        <property type="protein sequence ID" value="ABB64394"/>
        <property type="gene ID" value="SDY_4520"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4520"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5343"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_6"/>
    <dbReference type="OMA" id="WDQNKRQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="PTHR11879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="27"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="397" mass="43392" checksum="D2821068B09D1B16" modified="2005-12-06" version="1">MFQKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNEDGIIPQLKAVADAEARLNAVPHGASLYLPMEGLNSYRHAIAPLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPESGVWVSDPTWENHVAIFAGAGFEVSTYLWYDEATNGVRFNDLLATLKTLPASSIVLLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMEEDAYAIRAIASAGLPALVSNSFSKIFSLYGERVGGLSVLCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLNDEALKASWLAEVEEMRTRILAMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVVRLREEFGVYLIASGRMCVAGLNTANVQRVAKAFAAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Y7</accession>
    <name>Q327Y7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4942 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405859.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Y7"/>
    <dbReference type="STRING" id="300267.SDY_4492"/>
    <dbReference type="EnsemblBacteria" id="ABB64368">
        <property type="protein sequence ID" value="ABB64368"/>
        <property type="gene ID" value="SDY_4492"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4492"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5305"/>
    <dbReference type="HOGENOM" id="CLU_126476_0_0_6"/>
    <dbReference type="OMA" id="DKPETAM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031339">
        <property type="entry name" value="DUF4942"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13708">
        <property type="entry name" value="DUF4942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4942" evidence="1">
        <location>
            <begin position="59"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="114" mass="13383" checksum="BA4231C1275F3FE0" modified="2005-12-06" version="1">MRKSTLLQIDTLIRQLAEISAMTESIGGKTARDWAMKQDFRCGCWLMDKTETAMKAITRNLDREIWRDLMQRSGMLSLMDAQARDTWYRSLEYDNFPEISEANILSTFEQLHQN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q328M1</accession>
    <name>YSAB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein YsaB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ysaB</name>
        <name type="ordered locus">SDY_4343</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000980160.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405725.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328M1"/>
    <dbReference type="STRING" id="300267.SDY_4343"/>
    <dbReference type="EnsemblBacteria" id="ABB64234">
        <property type="protein sequence ID" value="ABB64234"/>
        <property type="gene ID" value="SDY_4343"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4343"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5127"/>
    <dbReference type="HOGENOM" id="CLU_162515_0_0_6"/>
    <dbReference type="OMA" id="NMAQLCK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025728">
        <property type="entry name" value="YsaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13983">
        <property type="entry name" value="YsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000268618" description="Uncharacterized lipoprotein YsaB">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="99" mass="11340" checksum="3F4F39002E536DC0" modified="2005-12-06" version="1" precursor="true">MMMNSFFPAMALMVLVGCSTPSPVQKAQRVKVDPLRSLNMEALCKDQAAKRYNTGEQKIDVTAFEQFQGSYEMRGYTFRKEQFVCSFDADGHFLHLSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q328R1</accession>
    <name>Q328R1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Citrate-dependent iron transport, outer membrane receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fecA</name>
        <name evidence="13" type="ordered locus">SDY_4297</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000188255.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405685.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328R1"/>
    <dbReference type="STRING" id="300267.SDY_4297"/>
    <dbReference type="EnsemblBacteria" id="ABB64194">
        <property type="protein sequence ID" value="ABB64194"/>
        <property type="gene ID" value="SDY_4297"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4297"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5066"/>
    <dbReference type="HOGENOM" id="CLU_008287_17_1_6"/>
    <dbReference type="OMA" id="IREDGPN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220571" evidence="11">
        <location>
            <begin position="34"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="12">
        <location>
            <begin position="56"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB64194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="774" mass="85291" checksum="92D4B6A64C1C3758" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q328S9</accession>
    <name>Q328S9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328S9"/>
    <dbReference type="EnsemblBacteria" id="ABB64176">
        <property type="protein sequence ID" value="ABB64176"/>
        <property type="gene ID" value="SDY_4275"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4275"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="YISIMLK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32004" checksum="BDE62AB6E8E7CE17" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAGTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMLKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Y3</accession>
    <name>Q328Y3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Caps_synth_GfcC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjbG</name>
        <name evidence="3" type="ordered locus">SDY_4220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000595562.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405613.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Y3"/>
    <dbReference type="STRING" id="300267.SDY_4220"/>
    <dbReference type="EnsemblBacteria" id="ABB64122">
        <property type="protein sequence ID" value="ABB64122"/>
        <property type="gene ID" value="SDY_4220"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4220"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4969"/>
    <dbReference type="HOGENOM" id="CLU_080984_2_0_6"/>
    <dbReference type="OMA" id="RQPIAYW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010425">
        <property type="entry name" value="Caps_synth_GfcC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06251">
        <property type="entry name" value="Caps_synth_GfcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220957" description="Caps_synth_GfcC domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Caps_synth_GfcC" evidence="2">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="245" mass="26251" checksum="517054EFC5A2F039" modified="2005-12-06" version="1">MIKQTIVALLLSVGASSVFAAGTVKVFSNGSSEAKTLTGAEHLIDLVGQPRLANSWWPGAVISEELATAAALRQQQALLTRLAEQGADSSADDAAAINALRQQIQVLKVTGRQKINLDPDIVRVAERANPPLQGNYTLWVGPPPSTVTLFGLISRPGNQPFTPGRDVASYLSGQSLLSGADRSYAWVVYPDGRTQKAPVAYWNKRHVEPMPGSIIYVGLADSVWSETPDALNADILQTLTQRIPQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q329B2</accession>
    <name>YIDC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidC</name>
        <name type="ordered locus">SDY_4188</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000378254.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405584.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329B2"/>
    <dbReference type="SMR" id="Q329B2"/>
    <dbReference type="STRING" id="300267.SDY_4188"/>
    <dbReference type="EnsemblBacteria" id="ABB64093">
        <property type="protein sequence ID" value="ABB64093"/>
        <property type="gene ID" value="SDY_4188"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4188"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4925"/>
    <dbReference type="HOGENOM" id="CLU_016535_3_0_6"/>
    <dbReference type="OMA" id="INPVAGC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028053">
        <property type="entry name" value="Membr_insert_YidC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01900">
        <property type="entry name" value="YIDCPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03593">
        <property type="entry name" value="yidC_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000070177" description="Membrane protein insertase YidC">
        <location>
            <begin position="1"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="548" mass="61500" checksum="8653F7DC29BB2EF4" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q329B5</accession>
    <name>RL34_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmH</name>
        <name type="ordered locus">SDY_4185</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000831330.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405581.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329B5"/>
    <dbReference type="SMR" id="Q329B5"/>
    <dbReference type="STRING" id="300267.SDY_4185"/>
    <dbReference type="EnsemblBacteria" id="ABB64090">
        <property type="protein sequence ID" value="ABB64090"/>
        <property type="gene ID" value="SDY_4185"/>
    </dbReference>
    <dbReference type="GeneID" id="64726505"/>
    <dbReference type="GeneID" id="67499950"/>
    <dbReference type="KEGG" id="sdy:SDY_4185"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4923"/>
    <dbReference type="HOGENOM" id="CLU_129938_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000013448" description="50S ribosomal protein L34">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <sequence length="46" mass="5380" checksum="600916E398939412" modified="2005-12-06" version="1">MKRTFQPSVLKRNRSHGFRARMATKNGRQVLARRRAKGRARLTVSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q329B6</accession>
    <name>DNAA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaA</name>
        <name type="ordered locus">SDY_4184</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000059101.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405580.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329B6"/>
    <dbReference type="SMR" id="Q329B6"/>
    <dbReference type="STRING" id="300267.SDY_4184"/>
    <dbReference type="EnsemblBacteria" id="ABB64089">
        <property type="protein sequence ID" value="ABB64089"/>
        <property type="gene ID" value="SDY_4184"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4184"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4922"/>
    <dbReference type="HOGENOM" id="CLU_026910_0_1_6"/>
    <dbReference type="OMA" id="REFNPLF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000048727" description="Chromosomal replication initiator protein DnaA">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <sequence length="467" mass="52536" checksum="6B3C35B8A73EC311" modified="2005-12-06" version="1">MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTSFCGADAPQLRFEVGTKPVTQTPQAAVTSNVAAPALVAQTQPQRAAPSTRSGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q329L8</accession>
    <name>Q329L8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">dfp</name>
        <name evidence="3" type="synonym">coaBC</name>
        <name evidence="7" type="ordered locus">SDY_4069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329L8"/>
    <dbReference type="STRING" id="300267.SDY_4069"/>
    <dbReference type="EnsemblBacteria" id="ABB63987">
        <property type="protein sequence ID" value="ABB63987"/>
        <property type="gene ID" value="SDY_4069"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4069"/>
    <dbReference type="HOGENOM" id="CLU_033319_0_1_6"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="211"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="215"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="332"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="430" mass="46341" checksum="479B429975A9A19C" modified="2005-12-06" version="1">MKARQQKYCDKIANFWCYPTGKIIMSLAGKKIVLGVSGGIAAYKTPELVRRLRDRGADVRVAMTEAAKAFITPLSLQAVSGYPVSDSLLDPAAEAAMGHIELGKWADLVILAPATADLIARVAAGMANDLVSTICLATPAPVAVIPAMNQQMYRAAATQHNLEVLASRGLLIWGPDSGSQACGDIGPGRMLDPLTIVDMAVAHFSPVNDLKHLNLMITAGPTREPLDPVRYISNHSSGKMGFAIAAAAARRGANVTLVSGPVSLPTPPFVKRVDVMTALEMEAAVNASIQQQNIFIGCAAVADYRAATVAPEKIKKQATQGDELTIKMVKNPDIVAGVAALKDHRPYVVGFAAETNNVEEYARQKRIRKNLDLICANDVSQPTQGFNSDNNALHLFWQDGDKVLPLERKELLGQLLLDEIVTRYDEKNRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q329M3</accession>
    <name>COAD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="1">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaD</name>
        <name type="ordered locus">SDY_4064</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001171879.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405473.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329M3"/>
    <dbReference type="SMR" id="Q329M3"/>
    <dbReference type="STRING" id="300267.SDY_4064"/>
    <dbReference type="EnsemblBacteria" id="ABB63982">
        <property type="protein sequence ID" value="ABB63982"/>
        <property type="gene ID" value="SDY_4064"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4064"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4780"/>
    <dbReference type="HOGENOM" id="CLU_100149_0_1_6"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000011239" description="Phosphopantetheine adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <sequence length="159" mass="17925" checksum="4DB77D321735D4AD" modified="2005-12-06" version="1">MQKRAIYPGTFDPITNGHIDIVTRATQMFDHVILAIAASPSKKTMFTLEERVELAQQATAHLGNVEVVGFSDLMANFARNQHATVLIRGLRAVADFEYEMQLAHMNRHLMPELESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPENVYQALMAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q329N0</accession>
    <name>Q329N0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipopolysaccharide core biosynthesis protein rfaY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rfaY</name>
        <name evidence="1" type="ordered locus">SDY_4057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000633087.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405466.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329N0"/>
    <dbReference type="STRING" id="300267.SDY_4057"/>
    <dbReference type="EnsemblBacteria" id="ABB63975">
        <property type="protein sequence ID" value="ABB63975"/>
        <property type="gene ID" value="SDY_4057"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4057"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4773"/>
    <dbReference type="HOGENOM" id="CLU_103657_0_0_6"/>
    <dbReference type="OMA" id="ICKANDL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009330">
        <property type="entry name" value="LipoPS_heptP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06176">
        <property type="entry name" value="WaaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="230" mass="26994" checksum="DC54009D3B1BB098" modified="2005-12-06" version="1">MITSIRYRGFSFYYKDNDNKYKEIFDEILAYNFKTVKVLRNIDDTKVSLIDTKYGRYVFKVFAPKTKRNERFLKSFVKGDYYQNLIVETDRVRSAGLTFPNDFYFLAERKIFNYASVFIMLIEYVEGVELNDMPIIPENVKAEIKASMEKLHALNMLSGDPHRGNFIVSKDGVRIIDLSGKSCTAERKARDRLAMERHLGIANEIKDYGYYSVIYRTKLRKFIKKLKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Q0</accession>
    <name>Q329Q0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lldR</name>
        <name evidence="5" type="ordered locus">SDY_4037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016731.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405446.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Q0"/>
    <dbReference type="STRING" id="300267.SDY_4037"/>
    <dbReference type="EnsemblBacteria" id="ABB63955">
        <property type="protein sequence ID" value="ABB63955"/>
        <property type="gene ID" value="SDY_4037"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4037"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4752"/>
    <dbReference type="HOGENOM" id="CLU_017584_9_5_6"/>
    <dbReference type="OMA" id="SFVVDFH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="258" mass="29175" checksum="C9D0D241FFBBD881" modified="2005-12-06" version="1">MIVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHDTWSEQNIVQPLKTLMADDPDNSFDILEARYAIEASTAWHAAMRATPDDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHNIVLLQTMRGFFDVLQSSVKHSRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDEDQARHARITRLPGEHNEHSREKNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q329S3</accession>
    <name>ATPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpA</name>
        <name type="ordered locus">SDY_4014</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001176745.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405423.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329S3"/>
    <dbReference type="SMR" id="Q329S3"/>
    <dbReference type="STRING" id="300267.SDY_4014"/>
    <dbReference type="EnsemblBacteria" id="ABB63932">
        <property type="protein sequence ID" value="ABB63932"/>
        <property type="gene ID" value="SDY_4014"/>
    </dbReference>
    <dbReference type="GeneID" id="67417721"/>
    <dbReference type="KEGG" id="sdy:SDY_4014"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4727"/>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_6"/>
    <dbReference type="OMA" id="LQAPGVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000238353" description="ATP synthase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="1">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <sequence length="513" mass="55222" checksum="DD1F3859375E9103" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q329T8</accession>
    <name>Q329T8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-ribose high-affinity transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rbsC</name>
        <name evidence="8" type="ordered locus">SDY_3997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000211864.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405408.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329T8"/>
    <dbReference type="STRING" id="300267.SDY_3997"/>
    <dbReference type="EnsemblBacteria" id="ABB63917">
        <property type="protein sequence ID" value="ABB63917"/>
        <property type="gene ID" value="SDY_3997"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3997"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4706"/>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_6"/>
    <dbReference type="OMA" id="RQFGMIF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="321" mass="33422" checksum="E2331EF2CEEE89A6" modified="2005-12-06" version="1">MTTQTVSGRRYFTKAWLMEQKSLIALLVLIAIVSTLSPNFFTINNLFNILQQTSVNAIMAVGMTLVILTSGIDLSVGSLLALTGAVAASIVGIEVNALVAVAAALALGAAIGAVTGVIVAKGRVQAFIATLVTMLLLRGVTMVYTNGSPVNTGFTENADLFGWFGIGRPLGVPTPVWIMGIVFLAAWYMLHHTRLGRYIYALGGNEAATRLSGINVNKIKIIVYSLCGLLASLAGIIEVARLSSAQPTAGTGYELDAIAAVVLGGTSLAGGKGRIVGTLIGALILGFLNNGLNLLGVSSYYQMIVKAVVILLAVLVDNKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q329V2</accession>
    <name>Q329V2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Positive regulator for ilvC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ilvY</name>
        <name evidence="3" type="ordered locus">SDY_3975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329V2"/>
    <dbReference type="STRING" id="300267.SDY_3975"/>
    <dbReference type="EnsemblBacteria" id="ABB63903">
        <property type="protein sequence ID" value="ABB63903"/>
        <property type="gene ID" value="SDY_3975"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3975"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_6"/>
    <dbReference type="OMA" id="FERDNRS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08430">
        <property type="entry name" value="PBP2_IlvY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037404">
        <property type="entry name" value="IlvY_PBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="319" mass="35625" checksum="4909C43C7B58CA08" modified="2005-12-06" version="1">MRKLIYSQRHIAISATSTLRAAPLDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKILPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q329W3</accession>
    <name>Q329W3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase</fullName>
            <ecNumber evidence="6">2.7.8.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Undecaprenyl-phosphate GlcNAc-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfe</name>
        <name evidence="6" type="synonym">wecA</name>
        <name evidence="7" type="ordered locus">SDY_3964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP</text>
            <dbReference type="Rhea" id="RHEA:28090"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:62959"/>
            <dbReference type="EC" id="2.7.8.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 4 family. WecA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.33" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001050951.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405383.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329W3"/>
    <dbReference type="STRING" id="300267.SDY_3964"/>
    <dbReference type="EnsemblBacteria" id="ABB63892">
        <property type="protein sequence ID" value="ABB63892"/>
        <property type="gene ID" value="SDY_3964"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3964"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4676"/>
    <dbReference type="HOGENOM" id="CLU_023982_1_0_6"/>
    <dbReference type="OMA" id="MCLGFLP"/>
    <dbReference type="UniPathway" id="UPA00281"/>
    <dbReference type="UniPathway" id="UPA00566"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009276">
        <property type="term" value="C:Gram-negative-bacterium-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036380">
        <property type="term" value="F:UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009246">
        <property type="term" value="P:enterobacterial common antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009243">
        <property type="term" value="P:O antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02030">
        <property type="entry name" value="WecA_Gammaproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012750">
        <property type="entry name" value="ECA_WecA-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02380">
        <property type="entry name" value="ECA_wecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="367" mass="40975" checksum="9FA8652ECA6D40D7" modified="2005-12-06" version="1">MNLLTVSTDLISIFLFTTLFLFFARKVAKKVGLVDKPNFRKRHQGLIPLVGGISVYAGICFTFGIVDYYIPHASLYLACAGMLVFIGALDDRFDISVKIRATIQAAVGIVMMVFGNLYLSSLGYIFGSWEMVLGPFGYFLTLFAVWAAINAFNMVDGIDGLLGGLSCVSFAAIGMILWFDGQTSLAIWCFAMIAAILPYIMLNLGILGRRYKVFMGDAGSTLIGFTVIWILLETTQGKTHPISPVTALWIIAIPLMDMVAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALLASIGVLAEYSHFVPEWVMLVLFLLAFFLYGYCIKRAWKVARFIKRVKRRLRRNRGGSPNLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A01</accession>
    <name>Q32A01_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yigJ</name>
        <name evidence="6" type="ordered locus">SDY_3920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A01"/>
    <dbReference type="STRING" id="300267.SDY_3920"/>
    <dbReference type="EnsemblBacteria" id="ABB63854">
        <property type="protein sequence ID" value="ABB63854"/>
        <property type="gene ID" value="SDY_3920"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3920"/>
    <dbReference type="HOGENOM" id="CLU_2011614_0_0_6"/>
    <dbReference type="OMA" id="WYSIVAV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="122" mass="13292" checksum="9020DD6E7C6518CC" modified="2005-12-06" version="1">MGYQMLHGALKKEAVSAPAPQVELAKSGRSFLKGLLTNLSNPKAIIYFGSVFSLFVGDNVGTTARWGIFALIIVETLAWFTVVASLFALPQMRRGYQRLAKWIDGFAGALFAGFGIHLIISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A40</accession>
    <name>Q32A40_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnL</name>
        <name evidence="5" type="ordered locus">SDY_3874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000190572.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405306.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A40"/>
    <dbReference type="STRING" id="300267.SDY_3874"/>
    <dbReference type="EnsemblBacteria" id="ABB63815">
        <property type="protein sequence ID" value="ABB63815"/>
        <property type="gene ID" value="SDY_3874"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3874"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4581"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_6"/>
    <dbReference type="OMA" id="EIMLTTA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="136"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="349" mass="38590" checksum="79CF7D518FC99B15" modified="2005-12-06" version="1">MATGTQPDAGQILNSLINSILLIDDNLAIHYANPAAQQLFAQSSRKLFGTPLPELLSYFSLNIELMQESLEAGQGFTDNEVTLVIDGRSHILSVTAQRMPDGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLEYTKVIIEQADRLRNLVDRLLGPQLPGTRVTESIHKVAERVVTLVSMELPDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQALGPEGGEIILRTRTAFQLTLHGERYRLAARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGHTEFSVYLPIRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AA5</accession>
    <name>HSLV_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent protease subunit HslV</fullName>
            <ecNumber evidence="1">3.4.25.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein HslV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hslV</name>
        <name type="ordered locus">SDY_3805</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent cleavage of peptide bonds with broad specificity.</text>
            <dbReference type="EC" id="3.4.25.2"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by HslU binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000208242.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405241.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AA5"/>
    <dbReference type="SMR" id="Q32AA5"/>
    <dbReference type="STRING" id="300267.SDY_3805"/>
    <dbReference type="MEROPS" id="T01.006"/>
    <dbReference type="EnsemblBacteria" id="ABB63750">
        <property type="protein sequence ID" value="ABB63750"/>
        <property type="gene ID" value="SDY_3805"/>
    </dbReference>
    <dbReference type="GeneID" id="67417555"/>
    <dbReference type="KEGG" id="sdy:SDY_3805"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4495"/>
    <dbReference type="HOGENOM" id="CLU_093872_1_0_6"/>
    <dbReference type="OMA" id="IMKGNAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01913">
        <property type="entry name" value="protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00248">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="PTHR32194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039093">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0915">Sodium</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0888">Threonine protease</keyword>
    <feature type="chain" id="PRO_1000012675" description="ATP-dependent protease subunit HslV">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00248"/>
        </source>
    </evidence>
    <sequence length="176" mass="19093" checksum="3B35E01F51486965" modified="2005-12-06" version="1">MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFELFERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AD0</accession>
    <name>Q32AD0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol dehydrogenase, (NAD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gldA</name>
        <name evidence="8" type="ordered locus">SDY_3780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63725.1"/>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
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            </authorList>
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</entry>
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    <accession>Q32AD5</accession>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
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                <person name="Yang J."/>
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                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
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            </authorList>
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        </location>
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    </evidence>
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            <dbReference type="RuleBase" id="RU362118"/>
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        </source>
    </evidence>
    <sequence length="386" mass="41566" checksum="423AC3035CA25E9E" modified="2005-12-06" version="1">MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAENPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHASMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AF4</accession>
    <name>Q32AF4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nusG</name>
        <name evidence="9" type="ordered locus">SDY_3746</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Interacts with the transcription termination factor Rho and with RNA polymerase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001287516.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405192.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AF4"/>
    <dbReference type="SMR" id="Q32AF4"/>
    <dbReference type="STRING" id="300267.SDY_3746"/>
    <dbReference type="EnsemblBacteria" id="ABB63701">
        <property type="protein sequence ID" value="ABB63701"/>
        <property type="gene ID" value="SDY_3746"/>
    </dbReference>
    <dbReference type="GeneID" id="66672107"/>
    <dbReference type="KEGG" id="sdy:SDY_3746"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4441"/>
    <dbReference type="HOGENOM" id="CLU_067287_1_0_6"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="181" mass="20532" checksum="B3AF94284CC17B04" modified="2005-12-06" version="1">MSEAPKKRWYVVQAFSGFEGRVATSLREHIKLHNMEDLFGEVMVPTEEVVEIRGGQRRKSERKFFPGYVLVQMVMNDASWHLVRSVPRVMGFIGGTSDRPAPISDKEVDAIMNRLQQVGDKPRPKTLFEPGEMVRVNDGPFADFNGVVEEVDYEKSRLKVSVSIFGRATPVELDFSQVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AI0</accession>
    <name>Q32AI0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS4 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AI0"/>
    <dbReference type="STRING" id="300267.SDY_3715"/>
    <dbReference type="EnsemblBacteria" id="ABB63675">
        <property type="protein sequence ID" value="ABB63675"/>
        <property type="gene ID" value="SDY_3715"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3715"/>
    <dbReference type="HOGENOM" id="CLU_028400_4_2_6"/>
    <dbReference type="OMA" id="HVIQHEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="257" mass="29445" checksum="BC6B3AAC8142D783" modified="2005-12-06" version="1">MTSHLLTAAAFGTMKNSENELAEQLIEQTGDNTLTLMDKGYYSLGLLNGWSLAGEHRHWMIPLRKGAQYEELRKLGKGDHLVKLKTSPQARKKWPGLGNEVTARLLTVTRKGKVCHLLTSMTDAMRFPGGEMADLYSHRWEIELGYREIKQTMQLSRLTLRSKKPELVEQELWGVLLAYNLVRYQMIKMAEHLKGYWPNQLSFSESCGMVMRMLMTLQGASPGRIPELMRDLASMGQLVKLPTRRERAFPRVVKERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AK8</accession>
    <name>Q32AK8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Penicillin-binding protein 1A</fullName>
            <ecNumber evidence="8">2.4.1.129</ecNumber>
            <ecNumber evidence="7">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">mrcA</name>
        <name evidence="22" type="ordered locus">SDY_3682</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="8"/>
    <dbReference type="EC" id="3.4.16.4" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AK8"/>
    <dbReference type="STRING" id="300267.SDY_3682"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63647">
        <property type="protein sequence ID" value="ABB63647"/>
        <property type="gene ID" value="SDY_3682"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3682"/>
    <dbReference type="HOGENOM" id="CLU_006354_2_4_6"/>
    <dbReference type="OMA" id="LAQMAMI"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031376">
        <property type="entry name" value="PCB_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17092">
        <property type="entry name" value="PCB_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="20">
        <location>
            <begin position="63"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PCB_OB" evidence="21">
        <location>
            <begin position="324"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="19">
        <location>
            <begin position="437"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF17092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ABB63647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="858" mass="94533" checksum="358D884C357AACC4" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AQ7</accession>
    <name>Q32AQ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative beta-ketoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_3629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000198477.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405089.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AQ7"/>
    <dbReference type="STRING" id="300267.SDY_3629"/>
    <dbReference type="EnsemblBacteria" id="ABB63598">
        <property type="protein sequence ID" value="ABB63598"/>
        <property type="gene ID" value="SDY_3629"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3629"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4308"/>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_6"/>
    <dbReference type="OMA" id="MNNNFAF"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="6">
        <location>
            <begin position="5"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="409" mass="44117" checksum="132FCBF0DCF850A4" modified="2005-12-06" version="1">MTRRVVITGMGGVTAFGENWQDVSARLLAYENAVRKMPEWQVYDGLHTLLGAPVDDFTPPEHYTRKRIRAMGRVSQMSTRASELALEQAGLIGDPILTSGETGIAYGSSTGSTGPVSEFATMLTEKHTNNITGTTYVQMMPHTTAVNTGLFFGLRGRVIPTSSACTSGSLAIGYAWEAIRHGYQTVMVAGGAEELCPSEAAVFDTLFATSQHNDAPKTTPSPFDENRDGLVIGEGAGTLILEELEHAKARGATIYGEIVGFATNCDAAHITQPQRETMQYCMEQSLKIAGLSAQDIGYISAHGTATDRGDMAESLATATIYGDNVPLSSLKSYFGHTLGACGALEAWMSLQMMREGWFAPTLNLNKPDPNCGALDYIMHEARKVDCEFLQSNNFAFGGINTSIIIKRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AW9</accession>
    <name>Q32AW9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glutathione oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gor</name>
        <name evidence="12" type="ordered locus">SDY_3562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000160832.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405027.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AW9"/>
    <dbReference type="STRING" id="300267.SDY_3562"/>
    <dbReference type="EnsemblBacteria" id="ABB63536">
        <property type="protein sequence ID" value="ABB63536"/>
        <property type="gene ID" value="SDY_3562"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3562"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4229"/>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_6"/>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="PTHR42737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="5"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="339"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="174"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="8">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="450" mass="48783" checksum="789FA0481A79B537" modified="2005-12-06" version="1">MTKHYDYIAIGGGSSGIASINRAAMYGQKCALIEAKELGGTCVNVGCVPKKVMWHAAQIREAIHMYGPDYGFDTTINKFNWETLIASRTAYIDRIHTSYENVLGKNNVDVIKGFARFVDAKTLEVNGETITADHILIATGGRPSHPDIPGVEYGIDSDGFFALPALPERVAVVGAGYIAVELAGVINGLGAKTHLFVRKHAPLRSFDPMISETLVEVMNAEGPQLHTNAIPKAVVKNADGSLTLELEDGRSETVDCLIWAIGREPANDNINLEAAGVKTNEKGYIVVDKYQNTNIEGIYAVGDNTGAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTVGLTEPQAREQYGDDQVKVYKSSFTAMYTAVTTHRQPCRMKLVCVGPEEKIVGIHGIGFGMDEMLQGFAVALKMGATKKDFDNTVAIHPTAAEEFVTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AX2</accession>
    <name>Q32AX2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arsenate reductase</fullName>
            <ecNumber evidence="3">1.20.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arsC</name>
        <name evidence="4" type="ordered locus">SDY_3559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[glutaredoxin]-dithiol + arsenate + glutathione + H(+) = arsenite + glutathionyl-S-S-[glutaredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:22016"/>
            <dbReference type="Rhea" id="RHEA-COMP:10729"/>
            <dbReference type="Rhea" id="RHEA-COMP:17668"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29242"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:48597"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:146199"/>
            <dbReference type="EC" id="1.20.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000065780.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405024.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AX2"/>
    <dbReference type="STRING" id="300267.SDY_3559"/>
    <dbReference type="EnsemblBacteria" id="ABB63533">
        <property type="protein sequence ID" value="ABB63533"/>
        <property type="gene ID" value="SDY_3559"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3559"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4224"/>
    <dbReference type="HOGENOM" id="CLU_116644_0_0_6"/>
    <dbReference type="OMA" id="HYLENPP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03034">
        <property type="entry name" value="ArsC_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006659">
        <property type="entry name" value="Arsenate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00014">
        <property type="entry name" value="arsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="141" mass="16023" checksum="FB1DD4430498C582" modified="2005-12-06" version="1">MSNITIYHNPACGTSRNTLEMIRNSGTEPTIIHYLETPPTRDQLVKLIADMRLTVRALLRKNVEPYEELDLAEDKFTDDRLIDFMLQHPILINRPIVVTPLGTRLCRPSEVVLEILPDAQKGAFSKEDGEKVVDKAGKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AX5</accession>
    <name>Q32AX5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhiF</name>
        <name evidence="3" type="ordered locus">SDY_3556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000478626.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405021.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AX5"/>
    <dbReference type="STRING" id="300267.SDY_3556"/>
    <dbReference type="EnsemblBacteria" id="ABB63530">
        <property type="protein sequence ID" value="ABB63530"/>
        <property type="gene ID" value="SDY_3556"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3556"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4219"/>
    <dbReference type="HOGENOM" id="CLU_1522929_0_0_6"/>
    <dbReference type="OMA" id="QMQTEDI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="176" mass="20481" checksum="E0E351FDFD5560FC" modified="2005-12-06" version="1">MFLIITRDTMFFTTMKNILSKGNVVHIQNEEEIDVMLHQNAFVIIDTLMNNVFHSNFLTQIERLKPVHVIIFSPFNIKRCLGKVPVTFVPRTITIIDFVALINGSYCSVPEANVSLSRKQHQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNLKRINELVRHQHIDYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B15</accession>
    <name>Q32B15_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NEM-activable K+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kefB</name>
        <name evidence="10" type="ordered locus">SDY_3512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABB63490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000399144.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404981.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B15"/>
    <dbReference type="STRING" id="300267.SDY_3512"/>
    <dbReference type="EnsemblBacteria" id="ABB63490">
        <property type="protein sequence ID" value="ABB63490"/>
        <property type="gene ID" value="SDY_3512"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3512"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4166"/>
    <dbReference type="HOGENOM" id="CLU_005126_9_3_6"/>
    <dbReference type="OMA" id="ANKMSIT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0050">Antiport</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="9">
        <location>
            <begin position="315"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="514" mass="57003" checksum="558353EFE077DA5D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BC3</accession>
    <name>Q32BC3_SHIDS</name>
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        <recommendedName>
            <fullName evidence="7">Aerobic respiration control sensor protein</fullName>
            <ecNumber evidence="7">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">arcB</name>
        <name evidence="18" type="ordered locus">SDY_3391</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 7">Cell inner membrane</location>
            <topology evidence="3 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000809775.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404873.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BC3"/>
    <dbReference type="STRING" id="300267.SDY_3391"/>
    <dbReference type="EnsemblBacteria" id="ABB63382">
        <property type="protein sequence ID" value="ABB63382"/>
        <property type="gene ID" value="SDY_3391"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3391"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4045"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_6"/>
    <dbReference type="OMA" id="VDWVIRL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027460">
        <property type="entry name" value="ArcB_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040642">
        <property type="entry name" value="HKR_ArcB_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014409">
        <property type="entry name" value="Sig_transdc_His_kin_hyb_ArcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18415">
        <property type="entry name" value="HKR_ArcB_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003182">
        <property type="entry name" value="ArcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="153"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="16">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="289"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="527"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="17">
        <location>
            <begin position="678"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="8">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8 10">
        <location>
            <position position="576"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="8 9">
        <location>
            <position position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR003182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR003182-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB63382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="778" mass="88025" checksum="DD61EA7EDE94AD30" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BD1</accession>
    <name>Q32BD1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">RNA polymerase sigma-54 factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">rpoN</name>
        <name evidence="14" type="ordered locus">SDY_3383</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the sigma-54 factor family.</text>
    </comment>
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    </dbReference>
    <dbReference type="RefSeq" id="YP_404865.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BD1"/>
    <dbReference type="STRING" id="300267.SDY_3383"/>
    <dbReference type="EnsemblBacteria" id="ABB63374">
        <property type="protein sequence ID" value="ABB63374"/>
        <property type="gene ID" value="SDY_3383"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3383"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4037"/>
    <dbReference type="HOGENOM" id="CLU_020569_0_1_6"/>
    <dbReference type="OMA" id="VTTQKFM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="9 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="13">
        <location>
            <begin position="116"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="12">
        <location>
            <begin position="317"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB63374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="477" mass="54052" checksum="CAAE764BA2CC160D" modified="2005-12-06" version="1">MKQGLQLRLSQQLAMTPQLQQAIRLLQLSTLELQQELQQALESNPLLEQIDTHEEIDTRETQDSETLDTADALEQKEMPEELPLDASWDTIYTAGTPSGTSGDYIDDELPVYQGETTQTLQDYLMWQVELTPFSDTDRAIATSIVDAVDDTGYLTVPLEDILESMGDEEIDIDEVEAVLKRIQRFDPVGVAAKDLRDCLLIQLSQFDKTTPWLEEARLIISDHLDLLANHDFRTLMRVTRLKEDVLKEAVNLIQSLDPRPGQSIQTDEPEYVIPDVLVRKHNGHWTVELNSDSIPRLQINQHYASMCNNARNDGDSQFIRSNLQDAKWLIKSLESRNDTLLRVSRCIVEQQQAFFEQGEEYMKPMVLADIAQAVEMHESTISRVTTQKYLHSPRGIFELKYFFSSHVNTEGGGEASSTAIRALVKKLIAAENPAKPLSDSKLTSLLSEQGIMVARRTVAKYRESLSIPPSNQRKQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BM3</accession>
    <name>Q32BM3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yqjC</name>
        <name evidence="3" type="ordered locus">SDY_3284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404773.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BM3"/>
    <dbReference type="STRING" id="300267.SDY_3284"/>
    <dbReference type="EnsemblBacteria" id="ABB63282">
        <property type="protein sequence ID" value="ABB63282"/>
        <property type="gene ID" value="SDY_3284"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3284"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3926"/>
    <dbReference type="HOGENOM" id="CLU_139075_0_0_6"/>
    <dbReference type="OMA" id="IRANCRD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009468">
        <property type="entry name" value="DUF1090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06476">
        <property type="entry name" value="DUF1090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220627" evidence="2">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="127" mass="14468" checksum="67F67C10A9573B86" modified="2005-12-06" version="1">MEGSRMKYRIALAVSLFALSAGSYATTLCQEKEQNILKEISYAEKHQNQNRIDGLNKALSEVRANCSDSQLRANHQKKIAKQKDEVAERQQDLTEAKQKGDADKIAKRERKLAEAQEELKTLEARDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BT5</accession>
    <name>Q32BT5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygiN</name>
        <name evidence="2" type="ordered locus">SDY_3211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000958585.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404711.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BT5"/>
    <dbReference type="STRING" id="300267.SDY_3211"/>
    <dbReference type="EnsemblBacteria" id="ABB63220">
        <property type="protein sequence ID" value="ABB63220"/>
        <property type="gene ID" value="SDY_3211"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3211"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3836"/>
    <dbReference type="HOGENOM" id="CLU_131496_13_1_6"/>
    <dbReference type="OMA" id="HLQTAHM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="104" mass="11513" checksum="A9AC410AFAC56BF1" modified="2005-12-06" version="1">MLTVIAEIRTHPGQHHRQAVLDQFAKIVPTVLKEEGCHGYAPMVDCAAGVSFQSMAPDSIVMIEQWESIAHLEAHLQTPHMKAYSEAVKGDVLEMNIRILQPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BY1</accession>
    <name>Q32BY1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BY1"/>
    <dbReference type="EnsemblBacteria" id="ABB63174">
        <property type="protein sequence ID" value="ABB63174"/>
        <property type="gene ID" value="SDY_3161"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3161"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="7814" checksum="5EC411B0FAD60FA7" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITLFRNKNVHPPSPASLSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CC4</accession>
    <name>QUEF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent 7-cyano-7-deazaguanine reductase</fullName>
            <ecNumber evidence="1">1.7.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NADPH-dependent nitrile oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queF</name>
        <name type="ordered locus">SDY_3011</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:13409"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="EC" id="1.7.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.13" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000100402.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404522.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CC4"/>
    <dbReference type="SMR" id="Q32CC4"/>
    <dbReference type="STRING" id="300267.SDY_3011"/>
    <dbReference type="EnsemblBacteria" id="ABB63031">
        <property type="protein sequence ID" value="ABB63031"/>
        <property type="gene ID" value="SDY_3011"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3011"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3615"/>
    <dbReference type="HOGENOM" id="CLU_054738_0_0_6"/>
    <dbReference type="OMA" id="QCVERIY"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046857">
        <property type="term" value="F:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033739">
        <property type="term" value="F:preQ1 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00817">
        <property type="entry name" value="QueF_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029500">
        <property type="entry name" value="QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029139">
        <property type="entry name" value="QueF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016428">
        <property type="entry name" value="QueF_type2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14489">
        <property type="entry name" value="QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14819">
        <property type="entry name" value="QueF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004750">
        <property type="entry name" value="Nitrile_oxidored_YqcD_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03138">
        <property type="entry name" value="QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000247720" description="NADPH-dependent 7-cyano-7-deazaguanine reductase">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimide intermediate" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="229"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00817"/>
        </source>
    </evidence>
    <sequence length="282" mass="32431" checksum="A68635CA1878EF28" modified="2005-12-06" version="1">MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGADIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTSFNNWDEVLKTLERDLSTCAQGKVSVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSIQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CL3</accession>
    <name>Q32CL3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404433.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CL3"/>
    <dbReference type="STRING" id="300267.SDY_2913"/>
    <dbReference type="EnsemblBacteria" id="ABB62942">
        <property type="protein sequence ID" value="ABB62942"/>
        <property type="gene ID" value="SDY_2913"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2913"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3498"/>
    <dbReference type="HOGENOM" id="CLU_125852_0_0_6"/>
    <dbReference type="OMA" id="VLRINEY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039060">
        <property type="entry name" value="Antitox_HigA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40455">
        <property type="entry name" value="PTHR40455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="107"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="161" mass="17982" checksum="758970CA99FE3D7C" modified="2005-12-06" version="1">MPSKPGILEKWASDTILQREQRMTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPVGVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CP0</accession>
    <name>Q32CP0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of plasmid mcrB operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">emrR</name>
        <name evidence="2" type="ordered locus">SDY_2879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000378440.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404406.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CP0"/>
    <dbReference type="STRING" id="300267.SDY_2879"/>
    <dbReference type="EnsemblBacteria" id="ABB62915">
        <property type="protein sequence ID" value="ABB62915"/>
        <property type="gene ID" value="SDY_2879"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2879"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3461"/>
    <dbReference type="HOGENOM" id="CLU_083287_17_1_6"/>
    <dbReference type="OMA" id="TEHAETY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="176" mass="20519" checksum="BB1C3E34DAD0718A" modified="2005-12-06" version="1">MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRLDQMEQAGVVLEAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CV9</accession>
    <name>Q32CV9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CV9"/>
    <dbReference type="EnsemblBacteria" id="ABB62846">
        <property type="protein sequence ID" value="ABB62846"/>
        <property type="gene ID" value="SDY_2803"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2803"/>
    <dbReference type="HOGENOM" id="CLU_2345110_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="97" mass="11256" checksum="23362C4AAFCA76AA" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITTNFNVLTNWRSRYSCHQYRFLRKGSSFYDKDCKLLVKDNYPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DC0</accession>
    <name>Q32DC0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404176.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DC0"/>
    <dbReference type="STRING" id="300267.SDY_2631"/>
    <dbReference type="EnsemblBacteria" id="ABB62685">
        <property type="protein sequence ID" value="ABB62685"/>
        <property type="gene ID" value="SDY_2631"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2631"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3169"/>
    <dbReference type="HOGENOM" id="CLU_115420_1_0_6"/>
    <dbReference type="OMA" id="CWQPVLW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021318">
        <property type="entry name" value="DUF2919"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11143">
        <property type="entry name" value="DUF2919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="151" mass="17363" checksum="862994F223B080F2" modified="2005-12-06" version="1">MKMKSTEFHPIHYDAHGRLRLPLLFWLVLLLQARTWVLFVIAGASREQGTALLNLFYPDHDNFWLGLIPGIPAVLAFLLSGRRATFPRTWRVLYFLLLLAQVVLLCWQPWLWLNGESVSGIGLALVVADIVALIWLLANRRLRACFNEVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DI0</accession>
    <name>Q32DI0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sucrose operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_2559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005017788.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404116.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DI0"/>
    <dbReference type="STRING" id="300267.SDY_2559"/>
    <dbReference type="EnsemblBacteria" id="ABB62625">
        <property type="protein sequence ID" value="ABB62625"/>
        <property type="gene ID" value="SDY_2559"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2559"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3083"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_6"/>
    <dbReference type="OMA" id="WYVYECA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="331" mass="36487" checksum="FE9DEA70C67B2B22" modified="2005-12-06" version="1">MASLKDVARLAGVSMMTVSRVMHNAESVRPATRDRVLQAIQTLNYVPDLSARKMRAQGRKPSTLAVLAQDTATTPFSVDILLAIEQTASEFGWNSFLINIFSEDDAARAARQLLAHRPDGIIYTTMGLRHITLPESLYGENIVLANCVADDPALPSYIPDDYTAQYESTQHLLAAGYRQPLCFWLPESALATGYRRQGFEQAWRDAGRDLAEVKQFHMATGDDHYTDLASLLNDHFKSGKPDFDVLICGNDRAAFVAYQVLLAKGVRIPQDVAVMGFDNLVGVGHLFLPPLTTIQLPHDIIGREAALHIIEGREGGKVTRIPCPLLIRCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DI1</accession>
    <name>Q32DI1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="4">3.2.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Invertase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_2558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Enables the bacterium to metabolize sucrose as a sole carbon source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycan biosynthesis; sucrose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000194514.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404115.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DI1"/>
    <dbReference type="STRING" id="300267.SDY_2558"/>
    <dbReference type="CAZy" id="GH32">
        <property type="family name" value="Glycoside Hydrolase Family 32"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62624">
        <property type="protein sequence ID" value="ABB62624"/>
        <property type="gene ID" value="SDY_2558"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2558"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3082"/>
    <dbReference type="HOGENOM" id="CLU_001528_7_0_6"/>
    <dbReference type="OMA" id="YKAGSGH"/>
    <dbReference type="UniPathway" id="UPA00238"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="6">
        <location>
            <begin position="29"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="7">
        <location>
            <begin position="333"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="477" mass="54410" checksum="4FA2DE702BE0E460" modified="2005-12-06" version="1">MTQSRLHAAQNALAKLHEHRGNTFYPHFHLAPPAGWMNDPNGLIWFNDRYHAFYQHHPMSEHWGPMHWGHATSDDMIHWQHEPIALAPGDDNDKDGCFSGSAVDDNGVLSLIYTGHVWLDGAGNDDAIREVQCLATSRDGIHFEKQGVILTPPEGIMHFRDPKVWREADTWWMVVGAKDPGNTGQILLYRGSSLREWTFDRVLAHADAGESYMWECPDFFSLGDQHYLMFSPQGMNAEGYSYRNRFQSGVIPGMWSPGRLFAQSGHFTELDNGHDFYAPQSFLAKDGRRIVIGWMDMWESPMPSKREGWAGCMTLARELSESNGKLLQHPVHEAESLRQQHQSISPRTISNKYVLQENAQAVEIQLQWALKNSDAEHYGLQLGTGMRLYIDNQSERLVLWRYYPHENLDGYRSIPLPQRDTLALRIFIDTSSVEVFINDGEAVMSSRIYPQPEERELSLYASHGVAVVQHGALWQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E00</accession>
    <name>Q32E00_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cold shock-like protein CspD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cspD</name>
        <name evidence="5" type="ordered locus">SDY_2381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000410785.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403946.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E00"/>
    <dbReference type="SMR" id="Q32E00"/>
    <dbReference type="STRING" id="300267.SDY_2381"/>
    <dbReference type="EnsemblBacteria" id="ABB62455">
        <property type="protein sequence ID" value="ABB62455"/>
        <property type="gene ID" value="SDY_2381"/>
    </dbReference>
    <dbReference type="GeneID" id="67414639"/>
    <dbReference type="KEGG" id="sdy:SDY_2381"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2874"/>
    <dbReference type="HOGENOM" id="CLU_117621_0_2_6"/>
    <dbReference type="OMA" id="HYSTIKM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012751">
        <property type="entry name" value="CspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02381">
        <property type="entry name" value="cspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="74" mass="7969" checksum="C74AB028135BC22C" modified="2005-12-06" version="1">MEKGTVKWFNNAKGFGFICPEGGGEDIFAHYSTIQMDGYRTLKAGQSVQFDVHQGPKGNHASVIVPVEVEAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E14</accession>
    <name>Q32E14_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anaerobic dimethyl sulfoxide reductase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dmsC</name>
        <name evidence="2" type="ordered locus">SDY_2365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000534674.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403932.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E14"/>
    <dbReference type="STRING" id="300267.SDY_2365"/>
    <dbReference type="EnsemblBacteria" id="ABB62441">
        <property type="protein sequence ID" value="ABB62441"/>
        <property type="gene ID" value="SDY_2365"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2365"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2858"/>
    <dbReference type="HOGENOM" id="CLU_064909_2_0_6"/>
    <dbReference type="OMA" id="MVRVYNT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019645">
        <property type="term" value="P:anaerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007059">
        <property type="entry name" value="DmsC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38095">
        <property type="entry name" value="PTHR38095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04976">
        <property type="entry name" value="DmsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="287" mass="30821" checksum="33CF7CF95BEB3992" modified="2005-12-06" version="1">MGSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAETQQRVIACMFGLWVLMGIGFIASMLHLGSPMRAFNSLNRVGASALSNEIASGSIFFAVGGIGWLLAMLKKLSPALRTLWLVVTMVLGVVFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMFMGGPLLGYLLLSLAGVDGWAMSLLPAISVLALVVSGVMSVMQGTELATIHSSVQQAAALVPDYGALMSWRIVLLAVALCLWIAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTVGMAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E23</accession>
    <name>Q32E23_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ycaP</name>
        <name evidence="9" type="ordered locus">SDY_2355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000642841.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403923.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E23"/>
    <dbReference type="STRING" id="300267.SDY_2355"/>
    <dbReference type="EnsemblBacteria" id="ABB62432">
        <property type="protein sequence ID" value="ABB62432"/>
        <property type="gene ID" value="SDY_2355"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2355"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2841"/>
    <dbReference type="HOGENOM" id="CLU_089304_0_0_6"/>
    <dbReference type="OMA" id="AVPMQNT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="230" mass="26313" checksum="339C634F06F00E10" modified="2005-12-06" version="1">MKAFDLHRMAFDKVPFDFLGEVALRSLYTFVLVFLFLKMTGRRGVRQMSLFEVLIILRLGSAAGDVAFYDDVPMVPVLIVFITLALLYRLVMWLMAHSEKLEDLLEGKSVVIIEDGELAWSKLNNSNMTEFEFFMELRLRGVEQLGQVRLAILETNGQISVYFFEDDKVKPGLLILPSDCTQRYKVVPESADYACIRCSEIIHMNAGEKQLCPRCANPEWTKASRAKRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EK2</accession>
    <name>Q32EK2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403744.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EK2"/>
    <dbReference type="STRING" id="300267.SDY_2167"/>
    <dbReference type="EnsemblBacteria" id="ABB62253">
        <property type="protein sequence ID" value="ABB62253"/>
        <property type="gene ID" value="SDY_2167"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2167"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2619"/>
    <dbReference type="HOGENOM" id="CLU_766709_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="323" mass="35621" checksum="E375E607AB540CB4" modified="2005-12-06" version="1">MRCWQDIEHYGLRIWFTDPDTGSILHLSRSWPRSEQENSPAATRRLFSFQAGALAGGQIVSQAAKRSADGDLLLATRNRLSSVVPLSPDAWQMLSAPLRQPGIVALREYLHQRPPACIRPLNQVDNLFILPVAECISLGWDSSRQTLDAQVISGEGEDNLLTLSLPVSASVPYAVERMAALLQQTDDPVCLVSGFVSFVDGQLTLEPQVMMTKTRAWALDAETTPVAPLPSASVLPVQSTAHQLLIRCQALLIQLLHNGWRYQEQSAISQAELLANDLTAVGFYRLAHVLGQFRNTESEARVEAMNNGVLLCEQLFPMLQQQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ES6</accession>
    <name>MDTH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Multidrug resistance protein MdtH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mdtH</name>
        <name type="ordered locus">SDY_2088</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="ABB62179" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62179.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ES6"/>
    <dbReference type="SMR" id="Q32ES6"/>
    <dbReference type="STRING" id="300267.SDY_2088"/>
    <dbReference type="EnsemblBacteria" id="ABB62179">
        <property type="protein sequence ID" value="ABB62179"/>
        <property type="gene ID" value="SDY_2088"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2088"/>
    <dbReference type="HOGENOM" id="CLU_108837_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01529">
        <property type="entry name" value="MFS_MdtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022855">
        <property type="entry name" value="Multidrug-R_MdtH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000280500" description="Multidrug resistance protein MdtH">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="159"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="234"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="297"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="360"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="401" mass="44255" checksum="9DAD3D2EF363984D" modified="2007-03-20" version="2">MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLVSIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCLLSGLGGTLFDPPRSALVVKLMPQQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLCAAFNAWLLPAWKLSTIRTPVREGMTRVMRDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDVAGAPSAVKWMYAIEACLSLTLLYPIARWSEKHFRLEHRLMAGLLIMSLSMMPVGMVSGLQQLFTLICLFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLAIGGTIGYIGGGWLFDLGKSAHQPELPWMMLGIIGIFTFLALGWQFSQKRAARRLLERDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EW0</accession>
    <name>Q32EW0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycfH</name>
        <name evidence="2" type="ordered locus">SDY_2050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000480245.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403636.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EW0"/>
    <dbReference type="SMR" id="Q32EW0"/>
    <dbReference type="STRING" id="300267.SDY_2050"/>
    <dbReference type="EnsemblBacteria" id="ABB62145">
        <property type="protein sequence ID" value="ABB62145"/>
        <property type="gene ID" value="SDY_2050"/>
    </dbReference>
    <dbReference type="GeneID" id="66670634"/>
    <dbReference type="KEGG" id="sdy:SDY_2050"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2465"/>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_6"/>
    <dbReference type="OMA" id="DGPYEYR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="265" mass="29809" checksum="722C9450157620C5" modified="2005-12-06" version="1">MFLVDSHCHLDGLDYESLHKDVDDVLAKAAARDVKFCLAVATTLPGYLHMRDLVGERDNVVFSCGVHPLNQNDPYDVEDLRRLAAEEGVVALGETGLDYYYTPETKVRQQESFIHHIQIGRELNKPVIVHTRDARADTLAILREEKVTDCGGVLHCFTEDRETAGKLLDLGFYISFSGIVTFRNAEQLRDAARYVPLDRLLVETDSPYLAPVPHRGKENQPAMVRDVAEYMAVLKGVAVEELAQVTTDNFARLFHIDASRLQSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EZ6</accession>
    <name>Q32EZ6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EZ6"/>
    <dbReference type="EnsemblBacteria" id="ABB62109">
        <property type="protein sequence ID" value="ABB62109"/>
        <property type="gene ID" value="SDY_2014"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2014"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7369" checksum="676834B195CE2723" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITHKGYVLITGCSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F03</accession>
    <name>Q32F03_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403593.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F03"/>
    <dbReference type="STRING" id="300267.SDY_2007"/>
    <dbReference type="EnsemblBacteria" id="ABB62102">
        <property type="protein sequence ID" value="ABB62102"/>
        <property type="gene ID" value="SDY_2007"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2007"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2419"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15334" checksum="FBCFF84A8DE0996B" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKIICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F30</accession>
    <name>Q32F30_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001262180.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403566.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F30"/>
    <dbReference type="STRING" id="300267.SDY_1975"/>
    <dbReference type="EnsemblBacteria" id="ABB62075">
        <property type="protein sequence ID" value="ABB62075"/>
        <property type="gene ID" value="SDY_1975"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1975"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2384"/>
    <dbReference type="HOGENOM" id="CLU_062618_6_0_6"/>
    <dbReference type="OMA" id="RHSMRMF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="75"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="263" mass="30056" checksum="AB5C2F36207BF027" modified="2005-12-06" version="1">MANADLDKQPDSVSSVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQEGESEKYSLTLKLFELGARALQNVDLIRSADIQMREISRLTKETIHLGALDEDSIVYIHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDRDEVKQILEGVEYKRSTERTITNTEALLPVLDQVREQGYGEDNEEQEEGLRCIAVPVFDRFGVVIAGLSISFPTLRFSEERLQEYVAMLHTAARKISAQMGYHDYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F69</accession>
    <name>Q32F69_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F69"/>
    <dbReference type="STRING" id="300267.SDY_1930"/>
    <dbReference type="EnsemblBacteria" id="ABB62036">
        <property type="protein sequence ID" value="ABB62036"/>
        <property type="gene ID" value="SDY_1930"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1930"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_1_6"/>
    <dbReference type="OMA" id="MSDECGP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038965">
        <property type="entry name" value="InsF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46889:SF1">
        <property type="entry name" value="PTHR46889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="173" mass="20208" checksum="A4C4C6877204A0A2" modified="2005-12-06" version="1">MTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKSGGVMFHSDQGSHYTSRQFRQLLWRYQIRQSMSRRGNCWDNSPMERFFRSLKNEWMPVVGYVSFSEAAHAITDYIVGYYSALRPHEYNGGLPPNESENRYWKNSNSVASFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F82</accession>
    <name>Q32F82_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403514.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F82"/>
    <dbReference type="EnsemblBacteria" id="ABB62023">
        <property type="protein sequence ID" value="ABB62023"/>
        <property type="gene ID" value="SDY_1917"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1917"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2308"/>
    <dbReference type="HOGENOM" id="CLU_1617903_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="164" mass="17742" checksum="259CAA64109B3F6F" modified="2005-12-06" version="1">MDIGGDSQVWTTAQFISWLESQGAFNHPYWMCKGSWAYANNKVITDTGCGNICLAGAVVEVTGTRGAMTIRVTTPGTSSGGGITNAQFTYINHGDAYAPGWRRDYNTKNQQPAFALGQTGSRVANDKAVGWNWNSGVYDADIKGATALILHFNKNTGSCEVYWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F86</accession>
    <name>Q32F86_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ynhD</name>
        <name evidence="6" type="ordered locus">SDY_1913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000948870.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403510.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F86"/>
    <dbReference type="STRING" id="300267.SDY_1913"/>
    <dbReference type="EnsemblBacteria" id="ABB62019">
        <property type="protein sequence ID" value="ABB62019"/>
        <property type="gene ID" value="SDY_1913"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1913"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2303"/>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_6"/>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="248" mass="27515" checksum="6FB5F6D60306831C" modified="2005-12-06" version="1">MLSIKDLHVSVEDKAILRGLSLDVRPGEVHAIMGPNGSGKSTLSATLAGREDYEVTGGTVEFKGKDLLALSPEDRAGEGIFMAFQYPVEIPGVSNQFFLQTALNAVRSYRGQETLDRFDFQDLMEDKIALLKMPEDLLTRSVNVGFSGGEKKRNDILQMAVLEPGLCILDESDSGLDIDALKVVADGVNSLRDGKRSFIIVTHYQRILDYIKPDYVHVLYQGRIVKSGDFTLVKQLEEQGYGWLTEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FF4</accession>
    <name>Q32FF4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS system, maltose and glucose-specific II ABC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">malX</name>
        <name evidence="11" type="ordered locus">SDY_1842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403442.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FF4"/>
    <dbReference type="STRING" id="300267.SDY_1842"/>
    <dbReference type="EnsemblBacteria" id="ABB61951">
        <property type="protein sequence ID" value="ABB61951"/>
        <property type="gene ID" value="SDY_1842"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1842"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2221"/>
    <dbReference type="HOGENOM" id="CLU_012312_1_0_6"/>
    <dbReference type="OMA" id="TATKWYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011301">
        <property type="entry name" value="PTS_Mal/Glc-sp_IIBC_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004719">
        <property type="entry name" value="PTS_maltose/Glc_sub_IIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00852">
        <property type="entry name" value="pts-Glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02004">
        <property type="entry name" value="PTS-IIBC-malX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="10">
        <location>
            <begin position="9"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB61951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="466" mass="49900" checksum="A125E399B010E662" modified="2005-12-06" version="1">MTAKTAPKVTLWEFFQQLGKTFMLPVALLSFCGIMLGIGSSLSSHDVITLLPVLGNPVLQAIFTWMSKIGSFAFSFLPVMFCIAIPLGLARENKGVAAFAGFVGYAVMNLAVNFWLTNKGILPTTDAAVLKANNIQSILGIQSIDTGILGAVIAGIIVWMLHERFHNIRLPDALAFFGGTRFVPIISSLVMGLVGLVIPLVWPIFAMGISGLGHMINSEGDFGPMLFGTGERLLLPFGLHHILVALIRFTDAGDTQEVCGQTVSGALTIFQAQLSCPTTHGFSESATRFLSQGKMPAFLGGLPGAALAMYHCARPENRHKIKGLLISGLIACVVGGTTEPLEFLFLFVAPVLYVIHALLTGLGFTVMSVLGVTIGNTDGNIIDFVVFGILHGLSTKWYIVPVVAAIWFVVYYVIFRFAITRFNLKTPGRDSEVASSIEKAVAGAPGKSGYNVPAVMLPISRTCVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FJ6</accession>
    <name>Q32FJ6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroH</name>
        <name evidence="7" type="ordered locus">SDY_1798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001082213.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403400.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FJ6"/>
    <dbReference type="STRING" id="300267.SDY_1798"/>
    <dbReference type="EnsemblBacteria" id="ABB61909">
        <property type="protein sequence ID" value="ABB61909"/>
        <property type="gene ID" value="SDY_1798"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1798"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2170"/>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_6"/>
    <dbReference type="OMA" id="PCLSWED"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="43"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="348" mass="38707" checksum="91330BBE46CA846B" modified="2005-12-06" version="1">MNRTDELRTARIESLVTPAELALRYPVTPGVATHVTDSRRRIEKILNGEDKQLLVIIGPCSIHDLTAAMEYATRLQSLRNQYQSRLEIVMRTYFEKPRTVVGWKGLISDPDLNGSYRVNHGLELARKLLLQVNELGVPTATEFLDMVTGQFIADLISWGAIGARTTESQIHREMASALSCPVGFKNGTDGNTRIAVDAIRAARASHMFLSPDKNGQMTIYQTSGNPYGHIIMRGGKKPNYHADDIAAACDTLHEFDLPEHLVVDFSHGNCQKQHRRQLEVCEDICQQIRNGSTAIAGIMAESFLREGTQKIVGSQPLTYGQSITDPCLGWEDTERLVEKLASAVDTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FM2</accession>
    <name>Q32FM2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403374.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FM2"/>
    <dbReference type="STRING" id="300267.SDY_1768"/>
    <dbReference type="EnsemblBacteria" id="ABB61883">
        <property type="protein sequence ID" value="ABB61883"/>
        <property type="gene ID" value="SDY_1768"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1768"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2130"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11096" checksum="6EB3A770DA5DAB68" modified="2005-12-06" version="1">MSRKTQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGPLGQWVTAARKGLGTPGSRTVAELESEILQLCKALNEACLERDILKKATAYFAQELLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FQ3</accession>
    <name>Q32FQ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein PotD/PotF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000047467.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403343.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FQ3"/>
    <dbReference type="STRING" id="300267.SDY_1734"/>
    <dbReference type="EnsemblBacteria" id="ABB61852">
        <property type="protein sequence ID" value="ABB61852"/>
        <property type="gene ID" value="SDY_1734"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1734"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2092"/>
    <dbReference type="HOGENOM" id="CLU_026974_1_5_6"/>
    <dbReference type="OMA" id="YDWVTGF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220959" evidence="2">
        <location>
            <begin position="23"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="381" mass="42323" checksum="7753CD2CD89C14F2" modified="2005-12-06" version="1">MSKTFARSSLCVLSMTIMTAHAAEPPTNLDKPEGRLDIIAWPGYIERGQTDKQYDWVTQFEKETGCAVNVKTAATSDEMVSLMTKGGYDLVTASGDASLRLIMGKRVQPINTALIPNWKTLDPRVVKGDWFNVGGKVYGTPYQWGPNLLMYNTKTFPTPPDSWQVVFVEQNLPDGKSNKGRVQAYDGPIYIADAALFVKATQPQLGISDPYQLTEEQYQAVLKVLRAQHSLIHRYWHDTTVQMSDFKNEGVVASSAWPYQANALKAEGQPVATVFPKEGVTGWADTTMLHSEAKHPVCAYKWMNWSLTPKVQGDVAAWFGSLPVVPEGCKASPLLGEKGCETNGFNYFDKIAFWKTPIAEGGKFVPYSRWTQDYIAIMGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FR1</accession>
    <name>Q32FR1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yncB</name>
        <name evidence="4" type="ordered locus">SDY_1724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403335.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FR1"/>
    <dbReference type="STRING" id="300267.SDY_1724"/>
    <dbReference type="EnsemblBacteria" id="ABB61844">
        <property type="protein sequence ID" value="ABB61844"/>
        <property type="gene ID" value="SDY_1724"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1724"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2079"/>
    <dbReference type="HOGENOM" id="CLU_026673_29_2_6"/>
    <dbReference type="OMA" id="GKDKCDY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="52"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="376" mass="40961" checksum="D88234FA2019CB47" modified="2005-12-06" version="1">MLQRGCDGCKQNQSREPATIDGFMPKAQESIMGQQKQRNRRWVLASCPHGAPVPENFRLEEDDVATPGEGQVLLRTVYLSLDPYMRGRMSDEPSYSPPVDIGGVMVGGTVSRVVESNHPDYQPGDWVLGYSGWQDYDISSGDDLVKLGDHPQNPSWSLGVLGMPGFTAYMGLLDIGQPKEGETLVVAAATGPVGATVGQIGKLKGCRVVGVAGGAEKCRHATEVLGFDVCLDHHADDFAEQLAKACPKGIDIYYENVGGKVFDAVLPLLNTSARIPVCGLVSSYNATELPPGPDRLPLLMATVLKKRIRLQGFIIAQDYGHRIHEFQKEMGQWVKEDKIHYREEITDGLENAPQTFIGLLKGKNFGKVVIRVAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FS5</accession>
    <name>Q32FS5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000290575.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403321.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FS5"/>
    <dbReference type="STRING" id="300267.SDY_1710"/>
    <dbReference type="EnsemblBacteria" id="ABB61830">
        <property type="protein sequence ID" value="ABB61830"/>
        <property type="gene ID" value="SDY_1710"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1710"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2064"/>
    <dbReference type="HOGENOM" id="CLU_100924_0_0_6"/>
    <dbReference type="OMA" id="MNATGYK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004658">
        <property type="entry name" value="OMP_Slp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37530">
        <property type="entry name" value="PTHR37530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03843">
        <property type="entry name" value="Slp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004982">
        <property type="entry name" value="SlP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00752">
        <property type="entry name" value="slp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="193" mass="20891" checksum="46D38F28A948A00E" modified="2005-12-06" version="1">MAVQKNVIKGILAGTFALMLSGCVTVPDAIKGSSPTPQQDLVRVMSAPQLYVGQEARFGGKVVAVQNQQGKTRLEIATVPLDSGARPTLGEPSRGRIYADVNGFLDPVDFRGQLVTVVGPITGAVDGKIGNTPYKFMVMQVTGYKRWHLTQQVIMPPQPIDPWFYGGRGWPYGYGGWGWYNPGPARVQTVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FY0</accession>
    <name>Q32FY0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cryptic nitrate reductase 2, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">narV</name>
        <name evidence="15" type="ordered locus">SDY_1653</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000617116.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403266.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FY0"/>
    <dbReference type="STRING" id="300267.SDY_1653"/>
    <dbReference type="EnsemblBacteria" id="ABB61775">
        <property type="protein sequence ID" value="ABB61775"/>
        <property type="gene ID" value="SDY_1653"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1653"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1993"/>
    <dbReference type="HOGENOM" id="CLU_092378_1_0_6"/>
    <dbReference type="OMA" id="FLPMSQK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="6"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB61775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="226" mass="26004" checksum="96CFB2DF61CCB49A" modified="2005-12-06" version="1">MIQYLNVFFYDIYPYICATVFFLGSWLRYDYGQYTWRASSSQMLDKRGMVIWSNLFHIGILGIFFGHLFGMLTPHWMYAWFLPVAAKQLMAMVLGGICGVLTLIGGAGLLWRRLTNQRVRATSTTPDIIIMSILLVQCLLGLSTIPFSAQYPDGSEMMKLVGWAQSIVTFRGGSSEMLNGVAFVFRLHLVLGMTIFLLFPFTRLVHVWSAPFEYFTRRYQIVRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G62</accession>
    <name>Q32G62_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G62"/>
    <dbReference type="EnsemblBacteria" id="ABB61693">
        <property type="protein sequence ID" value="ABB61693"/>
        <property type="gene ID" value="SDY_1557"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1557"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="9011" checksum="2E4DD41A9FDE1AE7" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITNSRSASSVIRIISTQINGFILLCVIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G97</accession>
    <name>Q32G97_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G97"/>
    <dbReference type="STRING" id="300267.SDY_1521"/>
    <dbReference type="EnsemblBacteria" id="ABB61658">
        <property type="protein sequence ID" value="ABB61658"/>
        <property type="gene ID" value="SDY_1521"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1521"/>
    <dbReference type="HOGENOM" id="CLU_045122_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="189" mass="20711" checksum="B0E7FE8D05B28A83" modified="2005-12-06" version="1">MLIMLTPDPAALKEAPDDATFARVTAPLWQYLDALHPYLWREGKDFPPSPARMDALLKAGTLRLSLTFNPAHAQQKIASGDLPASSYSFGFREGMIGNVHFVTIPANANASAAAKVVANFLLSPDAQLRKADPAVWGDPSVLDPQKLPDGQRETLQSRMPQDLPPVLAEPHAGWVNALEQEWLHRYGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GJ4</accession>
    <name>Q32GJ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GJ4"/>
    <dbReference type="EnsemblBacteria" id="ABB61561">
        <property type="protein sequence ID" value="ABB61561"/>
        <property type="gene ID" value="SDY_1417"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1417"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="93" mass="10497" checksum="1BB5A0BC01183064" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITHKTNDLTYIFVKSVTEENWQRMGKTVITLSPVTRTPGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GX1</accession>
    <name>Q32GX1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Regulator of RpoS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hnr</name>
        <name evidence="1" type="synonym">rssB</name>
        <name evidence="4" type="ordered locus">SDY_1287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co-degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to RpoS.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated. Phosphorylation stimulates the interaction with RpoS and, therefore, the proteolysis of RpoS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RssB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000193447.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402925.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GX1"/>
    <dbReference type="SMR" id="Q32GX1"/>
    <dbReference type="STRING" id="300267.SDY_1287"/>
    <dbReference type="EnsemblBacteria" id="ABB61434">
        <property type="protein sequence ID" value="ABB61434"/>
        <property type="gene ID" value="SDY_1287"/>
    </dbReference>
    <dbReference type="GeneID" id="58390554"/>
    <dbReference type="KEGG" id="sdy:SDY_1287"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1526"/>
    <dbReference type="HOGENOM" id="CLU_055989_1_0_6"/>
    <dbReference type="OMA" id="HWHLEYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00958">
        <property type="entry name" value="RssB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028616">
        <property type="entry name" value="RssB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1 2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="337" mass="37302" checksum="AB962EF94BC7B470" modified="2005-12-06" version="1">MTQPLVGKQILIVEDEQVFRSLLDSWFSSLGATTVLAADGVDALELLGGFTPDLMICDIAMPRMNGLKLLEHIRNRGDQTPVLVISATENMADIAKALRLGVEDVLLKPVKDLNRLREMVFACLYPSMFNSRVEEEERLFRDWDAMVDNPAAAAKLLQELQPPVQQVISHCRVNYRQLVAADKPGLVLDIAALSENDLAFYCLDVTRAGHNGVLAALLLRALFNGLLQEQLAHQNQRLPELGALLKQVNHLLRQANLPGQFPLLVGYYHRELKNLILVSAGLNATLNTGEHQVQISNGVPLGTLGNAYLNQLSQRCDAWQCQIWGTGGRLRLMLSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HC3</accession>
    <name>Q32HC3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000976472.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402773.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HC3"/>
    <dbReference type="STRING" id="300267.SDY_1125"/>
    <dbReference type="EnsemblBacteria" id="ABB61282">
        <property type="protein sequence ID" value="ABB61282"/>
        <property type="gene ID" value="SDY_1125"/>
    </dbReference>
    <dbReference type="GeneID" id="66674271"/>
    <dbReference type="KEGG" id="sdy:SDY_1125"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1326"/>
    <dbReference type="HOGENOM" id="CLU_164849_1_0_6"/>
    <dbReference type="OMA" id="STLMQYP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019648">
        <property type="entry name" value="YebY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10709">
        <property type="entry name" value="DUF2511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221106" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="113" mass="12392" checksum="82A3BC181F85D2CB" modified="2005-12-06" version="1">MMKKSILAFLLLTSSAAALAAPQVITVSRFEVGKDKWAFNREEVMLTCRPGNALYVINPSTLVQYPLNDIAQKEVASGKTKAQPISVIQIDDPNNPGEKMSLAPFIERAEKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HD5</accession>
    <name>Q32HD5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ftn</name>
        <name evidence="3" type="ordered locus">SDY_1113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000917208.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402761.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HD5"/>
    <dbReference type="SMR" id="Q32HD5"/>
    <dbReference type="STRING" id="300267.SDY_1113"/>
    <dbReference type="EnsemblBacteria" id="ABB61270">
        <property type="protein sequence ID" value="ABB61270"/>
        <property type="gene ID" value="SDY_1113"/>
    </dbReference>
    <dbReference type="GeneID" id="66674206"/>
    <dbReference type="KEGG" id="sdy:SDY_1113"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1307"/>
    <dbReference type="HOGENOM" id="CLU_065681_1_0_6"/>
    <dbReference type="OMA" id="CEDKGFE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="165" mass="19424" checksum="5B3AA08BCFE6CDA0" modified="2005-12-06" version="1">MLKPEMIEKLNEQMNLELYSSLLYQQMSAWCSYHTFEGAAAFLRRHAQEEMTHMQRLFDYLTDTGNLPRINTVESPFAEYSSLDELFQETYKHEQLITQKINELAHAAMTNQDYPTFNFLQWYVSEQHEEEKLFKSIIDKLSLAGKSGEGLYFIDKELSTLDTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HG0</accession>
    <name>Q32HG0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HG0"/>
    <dbReference type="EnsemblBacteria" id="ABB61245">
        <property type="protein sequence ID" value="ABB61245"/>
        <property type="gene ID" value="SDY_1082"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1082"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="7632" checksum="67C5C5090FD3F311" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITPFLILSVMFSLSADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HJ8</accession>
    <name>Q32HJ8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein DrpB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Division ring protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">drpB</name>
        <name evidence="2" type="ordered locus">SDY_1042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A non-essential division protein that localizes to the septal ring in low ionic strength medium.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes to the septal ring before constriction, only when cells are grown at low ionic strength.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DrpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402698.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HJ8"/>
    <dbReference type="STRING" id="300267.SDY_1042"/>
    <dbReference type="EnsemblBacteria" id="ABB61207">
        <property type="protein sequence ID" value="ABB61207"/>
        <property type="gene ID" value="SDY_1042"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1042"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1218"/>
    <dbReference type="HOGENOM" id="CLU_168880_1_0_6"/>
    <dbReference type="OMA" id="FYAFCGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00857">
        <property type="entry name" value="DrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046385">
        <property type="entry name" value="DrpB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="127" mass="14411" checksum="2C4E38ACA87CA99A" modified="2005-12-06" version="1">MTGSSNVEKCDFYHIIVLSLNFPGYLKMEYGSTKMEERLSRSPGGKLALWAFYTWCGYFVWAMARYIWVMSRIPDAPVSGFESDLGSTAGKWLGALVGFLFMALVGALLGSIAWYTRPRPARNRRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HS3</accession>
    <name>Q32HS3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ymcA</name>
        <name evidence="2" type="ordered locus">SDY_0960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000742364.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402623.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HS3"/>
    <dbReference type="STRING" id="300267.SDY_0960"/>
    <dbReference type="EnsemblBacteria" id="ABB61132">
        <property type="protein sequence ID" value="ABB61132"/>
        <property type="gene ID" value="SDY_0960"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0960"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1108"/>
    <dbReference type="HOGENOM" id="CLU_007558_1_0_6"/>
    <dbReference type="OMA" id="WARYASE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010344">
        <property type="entry name" value="YbjH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06082">
        <property type="entry name" value="YjbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220758" evidence="1">
        <location>
            <begin position="22"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="698" mass="78718" checksum="4B1EBA1D8324E3EB" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HY7</accession>
    <name>YEJL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0352 protein YejL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yejL</name>
        <name type="ordered locus">SDY_0892</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0352 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001135670.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402559.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HY7"/>
    <dbReference type="SMR" id="Q32HY7"/>
    <dbReference type="STRING" id="300267.SDY_0892"/>
    <dbReference type="EnsemblBacteria" id="ABB61068">
        <property type="protein sequence ID" value="ABB61068"/>
        <property type="gene ID" value="SDY_0892"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0892"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1032"/>
    <dbReference type="HOGENOM" id="CLU_175457_0_0_6"/>
    <dbReference type="OMA" id="HQAPTDL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00816">
        <property type="entry name" value="UPF0352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009857">
        <property type="entry name" value="UPF0352"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023202">
        <property type="entry name" value="YejL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07208">
        <property type="entry name" value="DUF1414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006188">
        <property type="entry name" value="UCP006188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158651">
        <property type="entry name" value="SSF158651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000062315" description="UPF0352 protein YejL">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00816"/>
        </source>
    </evidence>
    <sequence length="75" mass="8262" checksum="2B9DB1284903ED8D" modified="2005-12-06" version="1">MPQISRYSDEQVEQLLAELLNVLEKHKAPTDLSLMVSGNMVTNLINTSIAPAQRQAIANSFARALQSSINEDKAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I50</accession>
    <name>MOAA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="1">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">moaA</name>
        <name type="ordered locus">SDY_0825</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001408763.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402496.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I50"/>
    <dbReference type="SMR" id="Q32I50"/>
    <dbReference type="STRING" id="300267.SDY_0825"/>
    <dbReference type="EnsemblBacteria" id="ABB61007">
        <property type="protein sequence ID" value="ABB61007"/>
        <property type="gene ID" value="SDY_0825"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|300267.13.peg.951"/>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_6"/>
    <dbReference type="OMA" id="IEFMPIG"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
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        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
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        <property type="entry name" value="Mob_synth_C"/>
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        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="chain" id="PRO_1000054224" description="GTP 3',8-cyclase">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="8"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="329" mass="37274" checksum="DF1C5511BDB41213" modified="2005-12-06" version="1">MASQLTDAFARKFYYLRLSITDVCNFRCTYCLPDGYKPSGVTNKGFLTVDEIRRVTRAFASLGTEKVRLTGGEPSLRRDFTDIIAAVRENDAIRQIAVTTNGYRLERDVANWRDAGLTGINVSVDSLDARQFHAITGQDKFNQVMAGIDAAFEAGFEKVKVNTVLMRDVNHHQLDTFLNWIQHRPIQLRFIELMETGEGSELFRKHHISGQVLRDELLRRGWIHQLRQRSDGPAQVFCHPDYAGEIGLIMPYEKDFCATCNRLRVSSIGKLHLCLFGEGGVNLRDLLEDDAQQQALEARISAALREKKQTHFLHQNNTGITQNLSYIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I53</accession>
    <name>Q32I53_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moaD</name>
        <name evidence="5" type="ordered locus">SDY_0822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000598610.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402493.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I53"/>
    <dbReference type="STRING" id="300267.SDY_0822"/>
    <dbReference type="EnsemblBacteria" id="ABB61004">
        <property type="protein sequence ID" value="ABB61004"/>
        <property type="gene ID" value="SDY_0822"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0822"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.948"/>
    <dbReference type="HOGENOM" id="CLU_114601_4_0_6"/>
    <dbReference type="OMA" id="DRVHAKP"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="PTHR33359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="8809" checksum="756634052135F3A5" modified="2005-12-06" version="1">MIKVLFFAQVRELVGTDATEVAADFPTVEALRQHLAAQSDRWALALEDGKLLAAVNQTLVRFDHPLTDGDEVAFFPPVTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I59</accession>
    <name>Q32I59_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iso-IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_0816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402487.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I59"/>
    <dbReference type="STRING" id="300267.SDY_0816"/>
    <dbReference type="EnsemblBacteria" id="ABB60998">
        <property type="protein sequence ID" value="ABB60998"/>
        <property type="gene ID" value="SDY_0816"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0816"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.940"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="108" mass="12464" checksum="C0969043BCBC5817" modified="2005-12-06" version="1">MASVNIHCPRCQSAQVYRHGQNPKGHDRFRCRDCHRVFQLTYTYEARKPGIKELITEMAFNGAGVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITQYY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I85</accession>
    <name>RLMF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase F</fullName>
            <ecNumber evidence="1">2.1.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA mA1618 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA adenine N-6-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmF</name>
        <name type="ordered locus">SDY_0790</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the adenine in position 1618 of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16497"/>
            <dbReference type="Rhea" id="RHEA-COMP:10229"/>
            <dbReference type="Rhea" id="RHEA-COMP:10231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.181"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. METTL16/RlmF family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60972" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.1.1.181" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60972.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402461.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I85"/>
    <dbReference type="SMR" id="Q32I85"/>
    <dbReference type="STRING" id="300267.SDY_0790"/>
    <dbReference type="EnsemblBacteria" id="ABB60972">
        <property type="protein sequence ID" value="ABB60972"/>
        <property type="gene ID" value="SDY_0790"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0790"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.913"/>
    <dbReference type="HOGENOM" id="CLU_027534_3_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052907">
        <property type="term" value="F:23S rRNA (adenine(1618)-N(6))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01848">
        <property type="entry name" value="23SrRNA_methyltr_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016909">
        <property type="entry name" value="rRNA_lsu_MeTfrase_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="PTHR13393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029038">
        <property type="entry name" value="Mtase_YbiN_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000349969" description="Ribosomal RNA large subunit methyltransferase F">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="308" mass="34216" checksum="0A815459D56A8878" modified="2008-09-02" version="2">MSAQKPGLHPRNRHHSRYDLATLCQVNPELRQFLTLTPAGEQSVDFANPLAVKALNKALLAHFYAVANWDIPDGFLCPPVPGRADHIHHLADLLAEASGTIPANASILDIGVGANCIYPLIGVHEYGWRFTGSETSSQALSSAQAIISANPGLNRAIRLRRQKESGAIFNGIIHKNEQYDATLCNPPFHDSAAAARAGSERKRRNLGLNKDDALNFGGQQQELWCEGGEVTFIKKMIEESKGFAKQMMWFTSLVSRGENLPPLYRALTDVGAVKVVKKEMAQGQKQSRFIAWTFMNDEQRRRFVNRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IC9</accession>
    <name>Q32IC9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Modulator of drug activity A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mdaA</name>
        <name evidence="5" type="ordered locus">SDY_0744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the flavin oxidoreductase frp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000189165.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402417.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IC9"/>
    <dbReference type="STRING" id="300267.SDY_0744"/>
    <dbReference type="EnsemblBacteria" id="ABB60928">
        <property type="protein sequence ID" value="ABB60928"/>
        <property type="gene ID" value="SDY_0744"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0744"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.858"/>
    <dbReference type="HOGENOM" id="CLU_070764_0_2_6"/>
    <dbReference type="OMA" id="GMCLGYP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02146">
        <property type="entry name" value="NfsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016446">
        <property type="entry name" value="Flavin_OxRdtase_Frp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43425">
        <property type="entry name" value="PTHR43425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005426">
        <property type="entry name" value="Frp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="240" mass="26848" checksum="F34AB9C9E25A04FA" modified="2005-12-06" version="1">MTPTIELICGHRSIRHFTDEPISEAQREAIINSARATSSSSFLQCSSIIRITDKALREELVTLTGGQKHVAQAAEFWVFCADFNRHLQICPDAQLGLAEQLLLGVVDTAMMAQNALTAAESLGLGGVYIGGLRNNIEAVTELLKLPQHVLPLFGLCLGWPADNPDLKPRLPASILVHENSYQPLDKDALAQYDEQLAEYYLTRGSNNRRDTWSDHIRRTIIKESRPFILDYLHKQGWATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IJ2</accession>
    <name>Q32IJ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IJ2"/>
    <dbReference type="EnsemblBacteria" id="ABB60865">
        <property type="protein sequence ID" value="ABB60865"/>
        <property type="gene ID" value="SDY_0677"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0677"/>
    <dbReference type="HOGENOM" id="CLU_203300_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="60" mass="6966" checksum="D415DC0C8C8E23F6" modified="2005-12-06" version="1">MSLICELDEQWSFVGSKARQHWLWYAYNTKTGGDWPTLLVPVPMKPAGNYWHCLRHSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IJ4</accession>
    <name>Q32IJ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glutamate mutase L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001167716.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402352.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IJ4"/>
    <dbReference type="STRING" id="300267.SDY_0675"/>
    <dbReference type="EnsemblBacteria" id="ABB60863">
        <property type="protein sequence ID" value="ABB60863"/>
        <property type="gene ID" value="SDY_0675"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0675"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.788"/>
    <dbReference type="HOGENOM" id="CLU_046680_0_0_6"/>
    <dbReference type="OMA" id="LGMRYSA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006230">
        <property type="entry name" value="MutL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13941">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004729">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01319">
        <property type="entry name" value="glmL_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="462" mass="50620" checksum="CAB134B6B5B0372B" modified="2005-12-06" version="1">MQIVSVDIGSTWTKAALFTREGDALTLVNHVLTPTTTHHLAKGFFSSLNQVLNVDNTLPLLNSGEVALKYSSSAKGGLAVAAMGLVPSITLETAKVTAHSAGAKIAQYYAYKLNRRDIQALEETQPDILLFTGDTDGGEESYGLNNARVLAESKLDCAIIYAGNRDIQDEVQEILGHKDLTIVDNVLPDLDHPNPLAARQAICDIFLKRIVKGKGLDVIVDKTGEEPMPTPWTVFELVKAISNVDHNWKEFMLIDMGGATTDVYSACANTLSPDTVLHGVPEPFVKRTVEGDLGMRVSAVVVGESAKELVNVNFAQQPAQLDAFYHYLRHLVAHPDYLPANAEEKYFDTVLAGLCVGYATERHAGTKKEVCTCVGNVDLQMGRDLTTVRKVVGSGGWLSRASQFDMHHWLKYRELNDDGKRILLPTEFEYYRDSRGLLPLLANVARVDPLVAARTSIQCLTL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IQ0</accession>
    <name>SYQ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutaminyl-tRNA synthetase</fullName>
            <shortName evidence="1">GlnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glnS</name>
        <name type="ordered locus">SDY_0614</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001287129.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402296.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IQ0"/>
    <dbReference type="SMR" id="Q32IQ0"/>
    <dbReference type="STRING" id="300267.SDY_0614"/>
    <dbReference type="PRIDE" id="Q32IQ0"/>
    <dbReference type="EnsemblBacteria" id="ABB60807">
        <property type="protein sequence ID" value="ABB60807"/>
        <property type="gene ID" value="SDY_0614"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0614"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.711"/>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_6"/>
    <dbReference type="OMA" id="INNFCAQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00126">
        <property type="entry name" value="Gln_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022861">
        <property type="entry name" value="Gln_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000242876" description="Glutamine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="317"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="41"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00126"/>
        </source>
    </evidence>
    <sequence length="554" mass="63520" checksum="3F0B84F902CFD570" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IR0</accession>
    <name>Q32IR0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yleB</name>
        <name evidence="9" type="ordered locus">SDY_0598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000184535.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402286.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IR0"/>
    <dbReference type="STRING" id="300267.SDY_0598"/>
    <dbReference type="EnsemblBacteria" id="ABB60797">
        <property type="protein sequence ID" value="ABB60797"/>
        <property type="gene ID" value="SDY_0598"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0598"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.702"/>
    <dbReference type="HOGENOM" id="CLU_009665_8_3_6"/>
    <dbReference type="OMA" id="PELGYMV"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="8">
        <location>
            <begin position="6"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="391" mass="42942" checksum="4CF5C75396BDA54B" modified="2005-12-06" version="1">MTNQPTEIAIVGGGMVGGALALGLAQHGFAVTVIEHAEPALFVADSQPDVRISAISAASVSLLKGLGVWDAVQAMRCHPYRRLETWEWETAHVVFDAAELKLPLLGYMVENTVLQQALWQALEAHPKVTLRVPGSLIALLRHDDLQELELKGGEVIRAKLVIGADGANSQVRQMAGIGVHVWQYAQSCMLISVQCENDPGDSTWQQFTPDGPRAFLPLFDNWASLVWYDSPARIRQLQNMNMAQLQAEIAKHFPSRLGYVTPLAAGAFPLTRRHALQYVQPGLALVGDAAHTIHPLAGQGVNLGYRDVDALIDVLVNARSYGEAWASYPVLKRYQMRRMADNFIMQSGMDLFYAGFSNNLPPLRFVRNLGLMAAERAGVLKRQALKYALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IS7</accession>
    <name>Q32IS7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000940298.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402269.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IS7"/>
    <dbReference type="STRING" id="300267.SDY_0580"/>
    <dbReference type="EnsemblBacteria" id="ABB60780">
        <property type="protein sequence ID" value="ABB60780"/>
        <property type="gene ID" value="SDY_0580"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0580"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.680"/>
    <dbReference type="HOGENOM" id="CLU_096415_0_0_6"/>
    <dbReference type="OMA" id="FGVIWNE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009797">
        <property type="entry name" value="DUF1367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07105">
        <property type="entry name" value="DUF1367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="201" mass="23376" checksum="A9B12CEA303F20D6" modified="2005-12-06" version="1">MAHIQLVKQTSSGLLLPASCDFLHQIKIGEWIHADFKRVRNYAFHKRFFKLLQLGFDYWTPVGGAITPRERKLVSGFVDYLCESVGREHTPALSEAAEQYLNTVATRRTRDTALLAFREWVTIQAGFYTEHIYPDGSRGGRAKSIAFANMDETEFQQVYKSVLNVLWNWSLFRKFSSPEEVENVAAQLLEFEVYRALFWRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IU0</accession>
    <name>LPTE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LPS-assembly lipoprotein LptE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lptE</name>
        <name type="synonym">rlpB</name>
        <name type="ordered locus">SDY_0563</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LptE lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001269677.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402256.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IU0"/>
    <dbReference type="SMR" id="Q32IU0"/>
    <dbReference type="STRING" id="300267.SDY_0563"/>
    <dbReference type="EnsemblBacteria" id="ABB60767">
        <property type="protein sequence ID" value="ABB60767"/>
        <property type="gene ID" value="SDY_0563"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0563"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.665"/>
    <dbReference type="HOGENOM" id="CLU_103309_1_1_6"/>
    <dbReference type="OMA" id="TTVNRNY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01186">
        <property type="entry name" value="LPS_assembly_LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007485">
        <property type="entry name" value="LPS_assembly_LptE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38098">
        <property type="entry name" value="PTHR38098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04390">
        <property type="entry name" value="LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000281186" description="LPS-assembly lipoprotein LptE">
        <location>
            <begin position="19"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="193" mass="21287" checksum="C8E2D0B3DA21AEDC" modified="2005-12-06" version="1" precursor="true">MRYLATLLLSLAVLITAGCGWHLRDTTQVPSTMKVMILDSGDPNGPLSRAVRNQLRLNGVELLDKETTRKDVPSLRLGKVSIAKDTASVFRNGQTAEYQMIMTVNATVLIPGSDIYPISAKVFRSFFDNPQMALAKDNEQDMIVKEMYDRAAEQLIRKLPSIRAADIRSDEEQTSTTTDTPATPARVSTTLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IV7</accession>
    <name>Q32IV7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipid A palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402239.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IV7"/>
    <dbReference type="STRING" id="300267.SDY_0545"/>
    <dbReference type="EnsemblBacteria" id="ABB60750">
        <property type="protein sequence ID" value="ABB60750"/>
        <property type="gene ID" value="SDY_0545"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0545"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.645"/>
    <dbReference type="HOGENOM" id="CLU_202192_0_0_6"/>
    <dbReference type="OMA" id="DSHNEWQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009746">
        <property type="entry name" value="Peptid-resist/lipidA_acyl_PagP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07017">
        <property type="entry name" value="PagP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="10374" checksum="91A9DEB93183F603" modified="2005-12-06" version="1">MAFKDSWNKWEPIAGYGWESTWRPLADENFHLGLGFTAGVTARDNWNYIPLPVLLPLASVGYGPVTFQMTYIPGTYNNGNVYFAWMRFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IW5</accession>
    <name>Q32IW5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0536</name>
        <name evidence="3" type="ordered locus">SDY_0847</name>
        <name evidence="4" type="ordered locus">SDY_1428</name>
        <name evidence="5" type="ordered locus">SDY_1480</name>
        <name evidence="6" type="ordered locus">SDY_4469</name>
        <name evidence="7" type="ordered locus">SDY_4485</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402231.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402517.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405837.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405852.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0536"/>
    <dbReference type="EnsemblBacteria" id="ABB60742">
        <property type="protein sequence ID" value="ABB60742"/>
        <property type="gene ID" value="SDY_0536"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61028">
        <property type="protein sequence ID" value="ABB61028"/>
        <property type="gene ID" value="SDY_0847"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61571">
        <property type="protein sequence ID" value="ABB61571"/>
        <property type="gene ID" value="SDY_1428"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61619">
        <property type="protein sequence ID" value="ABB61619"/>
        <property type="gene ID" value="SDY_1480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64346">
        <property type="protein sequence ID" value="ABB64346"/>
        <property type="gene ID" value="SDY_4469"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64361">
        <property type="protein sequence ID" value="ABB64361"/>
        <property type="gene ID" value="SDY_4485"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0536"/>
    <dbReference type="KEGG" id="sdy:SDY_0847"/>
    <dbReference type="KEGG" id="sdy:SDY_1428"/>
    <dbReference type="KEGG" id="sdy:SDY_1480"/>
    <dbReference type="KEGG" id="sdy:SDY_4469"/>
    <dbReference type="KEGG" id="sdy:SDY_4485"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5272"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="WLWDISE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27529" checksum="73EC72C83C9B3BD1" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J52</accession>
    <name>RECR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recR</name>
        <name type="ordered locus">SDY_0447</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001195032.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402144.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J52"/>
    <dbReference type="SMR" id="Q32J52"/>
    <dbReference type="STRING" id="300267.SDY_0447"/>
    <dbReference type="EnsemblBacteria" id="ABB60655">
        <property type="protein sequence ID" value="ABB60655"/>
        <property type="gene ID" value="SDY_0447"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0447"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.530"/>
    <dbReference type="HOGENOM" id="CLU_060739_1_2_6"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_1000001612" description="Recombination protein RecR">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="81"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <sequence length="201" mass="21953" checksum="96263CCD539E44E8" modified="2005-12-06" version="1">MQTSPLLTQLMEALRCLSGVGPKSAQRMAFTLLQRDRSGGMRLAQALTRAMSEIGHCADCRTFTEQEVCNICSNPRRQENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLAEEKITEVILATNPTVEGEATANYIAELCAQYDVEASRIAHGVPVGGELEMVDGTTLSHSLAGRHKIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J90</accession>
    <name>Q32J90_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybbO</name>
        <name evidence="1" type="ordered locus">SDY_0406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000148920.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402106.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J90"/>
    <dbReference type="STRING" id="300267.SDY_0406"/>
    <dbReference type="EnsemblBacteria" id="ABB60617">
        <property type="protein sequence ID" value="ABB60617"/>
        <property type="gene ID" value="SDY_0406"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0406"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.483"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_6"/>
    <dbReference type="OMA" id="QMDVTDR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="269" mass="29395" checksum="DEED1EB727422ADF" modified="2005-12-06" version="1">MTHKATEILTGKVMPKSVLITGCSSGIGLESALELKRQGFHVLAGCRKPDDVERMNSMGFTGVLIDLDSPESVDRAADEVIALTDNCLYGIFNNAGFGMYGPLSTISRAQMEQQFSANFFGAHQLTMRLLPAMLPHGEGRIVMTSSVMGLISTPGRGAYAASKYALEAWSDALRMELRHSGIKVCLIEPGPIRTRFTDNVNQTQSDKPVENPGIAARFTLGPEAVVDKVRHAFISEKPKMRYPVTLVTWAVMVLKRLLPGRVMDKILQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JC8</accession>
    <name>Q32JC8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="6 14">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ddlA</name>
        <name evidence="14" type="synonym">ddl</name>
        <name evidence="18" type="ordered locus">SDY_0365</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="6 14"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000413699.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402068.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JC8"/>
    <dbReference type="STRING" id="300267.SDY_0365"/>
    <dbReference type="EnsemblBacteria" id="ABB60579">
        <property type="protein sequence ID" value="ABB60579"/>
        <property type="gene ID" value="SDY_0365"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0365"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.432"/>
    <dbReference type="HOGENOM" id="CLU_039268_0_0_6"/>
    <dbReference type="OMA" id="IDFFLTD"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="145"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB60579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="364" mass="39219" checksum="2CF9A70299B3487D" modified="2005-12-06" version="1">MEKLRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQGQWHVSDASNYLLNADDPAHIALSPSATSLAQVPGKHEHQLIDAQNGQPLPTVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFITLTRANRHNISFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYAIAADLAFEFDHKVIVEQGLKGREIECAVLGNDNPQASTCGEIVLTSDFYAYDTKYIDEDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINTLPGFTNISMYPKLWQASGLGYTDLITRLIELALERHAADNALKTTM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JJ2</accession>
    <name>TIG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trigger factor</fullName>
            <shortName evidence="1">TF</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tig</name>
        <name type="ordered locus">SDY_0296</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer and monomer. In vivo most of the ribosomes are in complex with monomeric TF. Uncomplexed TF, however, is in a monomer-dimer equilibrium with approximately two thirds of TF existing in a dimeric state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001198384.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402004.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JJ2"/>
    <dbReference type="SMR" id="Q32JJ2"/>
    <dbReference type="STRING" id="300267.SDY_0296"/>
    <dbReference type="EnsemblBacteria" id="ABB60515">
        <property type="protein sequence ID" value="ABB60515"/>
        <property type="gene ID" value="SDY_0296"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0296"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.341"/>
    <dbReference type="HOGENOM" id="CLU_033058_2_0_6"/>
    <dbReference type="OMA" id="KGIKTQF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000256616" description="Trigger factor">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="1">
        <location>
            <begin position="161"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <sequence length="432" mass="48165" checksum="54B284C335074164" modified="2005-12-06" version="1">MQVSVETTQGLGRRVTITIAADSIETAVKSELVNVAKKVRIDGFRKGKVPMNIVAQRYGASVRQDVLGDLMSRNFIDAIIKEKINPAGAPTYVPGEYKLGEDFTYSVEFEVYPEVELQGLEAIEVEKPIVEVTDADVDGMLDTLRKQQATWKEKDGAVEAEDRVTIDFTGSVDGEEFEGGKASDFVLAMGQGRMIPGFEDGIKGHKAGEEFTIDVTFPEEYHAENLKGKAAKFAINLKKVEERELPELTAEFIKRFGVEDGSVEGLRAEVRKNMERELKSAIRNRVKSQAIEGLVKANDIDVPAALIDSEIDVLRRQAAQRFGGNEKQALELPRELFEEQAKRRVVVGLLLGEVIRTNELKADEERVKGLIEEMASAYEDPKEVIEFYSKNKELMDNMRNVALEEQAAEAVLAKAKVTEKETTFNELMNQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JQ7</accession>
    <name>Q32JQ7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yaeD</name>
        <name evidence="13" type="ordered locus">SDY_0219</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28518"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60208"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="3.1.3.82"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the gmhB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001140169.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401939.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JQ7"/>
    <dbReference type="STRING" id="300267.SDY_0219"/>
    <dbReference type="EnsemblBacteria" id="ABB60450">
        <property type="protein sequence ID" value="ABB60450"/>
        <property type="gene ID" value="SDY_0219"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0219"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.253"/>
    <dbReference type="HOGENOM" id="CLU_085077_3_0_6"/>
    <dbReference type="OMA" id="EHQICLE"/>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034200">
        <property type="term" value="F:D,D-heptose 1,7-bisphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004682">
        <property type="entry name" value="GmhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00213">
        <property type="entry name" value="GmhB_yaeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="19"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="53"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="110"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="11">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to substrate recognition" evidence="11">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="11">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB60450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="190" mass="21190" checksum="3E939E15D9825BCE" modified="2005-12-06" version="1">MAKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIARGKFTEAQFETLTEWMDWSLADRDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMFLSARDYLHIDMAASYMVGDKLEDMQAAVAANVGTKVLVRTGKSITPEAENAADWVLNSLADLPQAIKKQKKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JS0</accession>
    <name>Q32JS0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="7">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mesJ</name>
        <name evidence="7" type="synonym">tilS</name>
        <name evidence="9" type="ordered locus">SDY_0206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000176586.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401926.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JS0"/>
    <dbReference type="STRING" id="300267.SDY_0206"/>
    <dbReference type="EnsemblBacteria" id="ABB60437">
        <property type="protein sequence ID" value="ABB60437"/>
        <property type="gene ID" value="SDY_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0206"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.240"/>
    <dbReference type="HOGENOM" id="CLU_018869_2_0_6"/>
    <dbReference type="OMA" id="QTETFFL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TilS_C" evidence="8">
        <location>
            <begin position="356"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="431" mass="47985" checksum="24B7DEE292327744" modified="2005-12-06" version="1">MTLTLNRQLLTSRQILVAFSGGLDSTVLLHQLVQWRTENPGVVLRAIHVHHGLSANADAWVTHCENVCQQWQVPLVVERVQLAQEGLGIEAQARQARYQAFARTLLPGEVLVTAQHLDDQCETFLLALKRGSGPAGLSAMAEVSEFAGTRLIRPLLARTRGELAQWALAHGLRWIEDESNQDDSYDRNFLRLRVVPLLQQRWPHFAETTARSAALCAEQESLLDELLADDLAHCQSPQGTLQIAPMLAMSDARRAAIIRRWLAGQNAPMPSRDALVRIWQEVALAREDASPCLRFGAFEIRRYQSQLWWIKSVTGQSETIVPWQTWLQPLELPAGLGSVQLNAGGDIRPPRADEAVSVRFKALGLLHIVGRNGGRKLKKIWQELGVPPWLRDTTPLLFYGETLIAAAGVFVTQEGVAEGENGISFVWQRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JU1</accession>
    <name>Q32JU1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Methionine aminopeptidase</fullName>
            <shortName evidence="3">MAP</shortName>
            <shortName evidence="3">MetAP</shortName>
            <ecNumber evidence="3 4">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">map</name>
        <name evidence="6" type="ordered locus">SDY_0184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3 4">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001018194.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401905.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JU1"/>
    <dbReference type="SMR" id="Q32JU1"/>
    <dbReference type="STRING" id="300267.SDY_0184"/>
    <dbReference type="MEROPS" id="M24.001"/>
    <dbReference type="EnsemblBacteria" id="ABB60416">
        <property type="protein sequence ID" value="ABB60416"/>
        <property type="gene ID" value="SDY_0184"/>
    </dbReference>
    <dbReference type="GeneID" id="66671544"/>
    <dbReference type="KEGG" id="sdy:SDY_0184"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.213"/>
    <dbReference type="HOGENOM" id="CLU_015857_0_0_6"/>
    <dbReference type="OMA" id="GDHAYTF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="12"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="264" mass="29331" checksum="F2D0B57715A67851" modified="2005-12-06" version="1">MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JX7</accession>
    <name>Q32JX7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA</name>
        <name evidence="16" type="ordered locus">SDY_0146</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000102483.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401869.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JX7"/>
    <dbReference type="STRING" id="300267.SDY_0146"/>
    <dbReference type="EnsemblBacteria" id="ABB60380">
        <property type="protein sequence ID" value="ABB60380"/>
        <property type="gene ID" value="SDY_0146"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0146"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.164"/>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_6"/>
    <dbReference type="OMA" id="HMVGDRM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="8"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="347"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="319"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB60380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="474" mass="50674" checksum="ED16139D3BD8343A" modified="2005-12-06" version="1">MSTEIKTQVVVLGAGPAGYSAAFRCADLGLETVIVERYNTLGGVCLNVGCIPSKALLHVAKVIEEAKALAEHGIVFGEPKTDIDKIRTWKEKVINQLTGGLAGMAKGRKVKVVNGLGKFTGANTLEVEGENGKTVINFDNAIIAAGSRPIQLPFIPHEDPRIWDSTDALELKEVPERLLVMGGGIIGLEMGTVYHALGSQIDVVEMFDQVIPAADKDIVKVFTKRISKKFNLMLETKVTAVEAKEDGIYVTMEGKKAPAEPQRYDAVLVAIGRVPNGKNLDAGKAGVEVDDRGFIRVDKQLRTNVPHIFAIGDIVGQPMLAHKGVHEGHVAAEVIAGKKHYFDPKVIPSIAYTEPEVAWVGLTEKEAKEKGISYETATFPWAASGRAIASDCADGMTKLIFDKESHRVIGGAIVGSNGGELLGEIGLAIEMGCDAEDIALTIHAHPTLHESVGLAAEVFEGSITDLPNPKAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JZ8</accession>
    <name>Q32JZ8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ftsA</name>
        <name evidence="8" type="ordered locus">SDY_0124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000588474.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401848.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JZ8"/>
    <dbReference type="SMR" id="Q32JZ8"/>
    <dbReference type="STRING" id="300267.SDY_0124"/>
    <dbReference type="EnsemblBacteria" id="ABB60359">
        <property type="protein sequence ID" value="ABB60359"/>
        <property type="gene ID" value="SDY_0124"/>
    </dbReference>
    <dbReference type="GeneID" id="67416167"/>
    <dbReference type="KEGG" id="sdy:SDY_0124"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.143"/>
    <dbReference type="HOGENOM" id="CLU_037850_3_2_6"/>
    <dbReference type="OMA" id="DGIIRHT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="10"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="420" mass="45330" checksum="C2475377A229B982" modified="2005-12-06" version="1">MIKATDRKLVVGLEIGTAKVAALVGEVLPDGMVNIIGVGSCPSRGMDKGGVNDLESVVKCVQRAIDQAELMADCQISSVYLALSGKHISCQNEIGMVPISEEEVTQEDVENVVHTAKSVRVRDEHRVLHVIPQEYAIDYQEGIKNPVGLSGVRMQAKVHLITCHNDMAKNIVKAVERCGLKVDQLIFAGLASSYSVLTEDERELGVCVVDIGGGTMDIAVYTGGALRHTKVIPYAGNVVTSDIAYAFGTPPSDAEAIKVRHGCALGSIVGKDESVEVPSVGGRPPRSLQRQTLAEVIEPRYTELLNLVNEEILQLQEKLRQQGVKHHLAAGIVLTGGAAQIEGLAACAQRVFHTQVRIGAPLNITGLTDYAQEPYYSTAVGLLHYGKESHLNGEAEVEKRVTASVGSWIKRLNSWLRKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K80</accession>
    <name>Q32K80_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K80"/>
    <dbReference type="STRING" id="300267.SDY_0039"/>
    <dbReference type="EnsemblBacteria" id="ABB60277">
        <property type="protein sequence ID" value="ABB60277"/>
        <property type="gene ID" value="SDY_0039"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0039"/>
    <dbReference type="HOGENOM" id="CLU_1863812_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221058" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="137" mass="14685" checksum="1D72EDE8E1283E8F" modified="2005-12-06" version="1">MYKQAVIPLLMLFTASVSAALPARYMQTIENAAVWEQIGDKMVTEGNIRAGQIIAVEPTAASYYAFNFGFGKGFIDKGHLEPVQGRQKVEDGLGDLNKPLSNQNLVTWKDTPVYNAPSAGSAPFGGTGGQFALPDFA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KB5</accession>
    <name>KHSE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homoserine kinase</fullName>
            <shortName evidence="1">HK</shortName>
            <shortName evidence="1">HSK</shortName>
            <ecNumber evidence="1">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrB</name>
        <name type="ordered locus">SDY_0003</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000241660.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401731.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KB5"/>
    <dbReference type="SMR" id="Q32KB5"/>
    <dbReference type="STRING" id="300267.SDY_0003"/>
    <dbReference type="EnsemblBacteria" id="ABB60243">
        <property type="protein sequence ID" value="ABB60243"/>
        <property type="gene ID" value="SDY_0003"/>
    </dbReference>
    <dbReference type="GeneID" id="66671706"/>
    <dbReference type="KEGG" id="sdy:SDY_0003"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2"/>
    <dbReference type="HOGENOM" id="CLU_041243_1_1_6"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0791">Threonine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000049164" description="Homoserine kinase">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <sequence length="310" mass="33610" checksum="0F225F9F1AC85158" modified="2005-12-06" version="1">MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPDTAQRVADWLGKNYLQNQEGFVHICRLDTAGARVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q326T0</accession>
    <name>Q326T0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IpaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ipaC</name>
        <name evidence="5" type="ordered locus">SDY_P165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Sd197</strain>
            <plasmid evidence="6">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the invasin protein C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000405469.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406166.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326T0"/>
    <dbReference type="EnsemblBacteria" id="ABB64678">
        <property type="protein sequence ID" value="ABB64678"/>
        <property type="gene ID" value="SDY_P165"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P165"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5724"/>
    <dbReference type="HOGENOM" id="CLU_723395_0_0_6"/>
    <dbReference type="OMA" id="MEIQNTK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005427">
        <property type="entry name" value="BacInvasinC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09599">
        <property type="entry name" value="IpaC_SipC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02101">
        <property type="entry name" value="IpaC_SipC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="363" mass="38754" checksum="F17B244CA74FC9AB" modified="2005-12-06" version="1">MEIQNTKPTQILYTDISTKQTQSSSETQKSQNYQQIAAHIPLNAGKNPVLTTTLNDDQLVKLSEQVQHDSEIIARLTDKKMKDLSEMSHTITPENTLDISSLSSNAVSLIISVAVLLSALRTAETKLGSQLSLIAFDATKSAAENIVRQGLAALSSSITGAVTQVGITGIGAKKTHSGISEQKGALRKNLATAQSLEKELAGSKLGLNKQIDTNITSPQTNSSTKILGKNKLAPDNISLSTEHKTSLSSPDISLQDKIDTQRRAYELNTLSAQQKQNIGRATMETSAVAGNISTSGGRYASALEEEEQLISQASSKQAEEASQVSKEASQATNQLIQKLLNIIDNINQSRSSTASQIAGNIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q326W8</accession>
    <name>Q326W8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406128.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326W8"/>
    <dbReference type="EnsemblBacteria" id="ABB64640">
        <property type="protein sequence ID" value="ABB64640"/>
        <property type="gene ID" value="SDY_P127"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P127"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5681"/>
    <dbReference type="HOGENOM" id="CLU_2304108_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002071">
        <property type="entry name" value="Thermonucl_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01123">
        <property type="entry name" value="TNASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11624" checksum="7508E867983881FC" modified="2005-12-06" version="1">MLHYSGGLKYRCHLSDMENNMRKYIPLVLFIFSWPVLSADIHGRVVRVLDGDTIEVMDSLKAVRIRLVNIDAPEGNDSNLLIVFYVQIMPDDFVMQLHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q326X0</accession>
    <name>Q326X0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fertility inhibition protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Conjugal transfer repressor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">finO</name>
        <name evidence="10" type="ordered locus">SDY_P125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Sd197</strain>
            <plasmid evidence="11">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the components on the FinOP fertility inhibition complex, which inhibits the expression of traJ gene, which in turn regulates the expression of some 20 transfer genes. The transfer genes are responsible for the process, called conjugal transfer, in which DNA is transmitted from one bacterial host to another. RNA-binding that interacts with the traJ mRNA and its antisense RNA, finP, stabilizing finP against endonucleolytic degradation and facilitating sense-antisense RNA recognition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FinO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000139365.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406126.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326X0"/>
    <dbReference type="EnsemblBacteria" id="ABB64638">
        <property type="protein sequence ID" value="ABB64638"/>
        <property type="gene ID" value="SDY_P125"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P125"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5680"/>
    <dbReference type="HOGENOM" id="CLU_120874_0_0_6"/>
    <dbReference type="OMA" id="YVTEYIS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021065">
        <property type="entry name" value="Fertility_inhibition_FinO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016103">
        <property type="entry name" value="ProQ/FinO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036442">
        <property type="entry name" value="ProQ/FinO_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12602">
        <property type="entry name" value="FinO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04352">
        <property type="entry name" value="ProQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00945">
        <property type="entry name" value="ProQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48657">
        <property type="entry name" value="SSF48657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0184">Conjugation</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ProQ" evidence="9">
        <location>
            <begin position="68"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="186" mass="21059" checksum="D0C9C9503F56713B" modified="2005-12-06" version="1">MTEQKRPVLTLKRKTEGTAPVRSRKTIINVTTPPKWKVKKQKLAEKAAREAELAAKKAQARQALSIYLNLPTLDEAVNILKPWWPGLFDGDTPRLLACGIRDVLLEDVAQRDIPLSHKKLRRALKAITRSESYLCAMKAGACRYDTEGYVTEHISQEEEAYAGARLAKIRRQNRIKAELQAVLDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q326X2</accession>
    <name>Q326X2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA helicase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406124.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326X2"/>
    <dbReference type="EnsemblBacteria" id="ABB64636">
        <property type="protein sequence ID" value="ABB64636"/>
        <property type="gene ID" value="SDY_P123"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P123"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5678"/>
    <dbReference type="HOGENOM" id="CLU_001748_3_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009767">
        <property type="entry name" value="DNA_helicase_TraI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07057">
        <property type="entry name" value="TraI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TraI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="230" mass="25123" checksum="E5A33232D226B4D2" modified="2005-12-06" version="1">MALPAFDRNGKSAGIWLNPLTTDDGNGLRGFSGEGRVKGSGDAQFVALQGSRNGESLLADNMQDGVRIARDNPDSGVVVRIAGEGRPWNPGAITGGRVWGDIPDNSVQPGAGNGEPVTAEVLAQRQAEEAIRRETERRADEIVRKMAENKPDLPDGKTEQAVREIAGQERDRAAITEREAALPESVLREPQRVREAVREVARENLLQERLQQMERDMVRDLQKEKTPGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Z8</accession>
    <name>Q326Z8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Toxin CcdB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cytotoxic protein CcdB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein LetD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccdB</name>
        <name evidence="5" type="ordered locus">SDY_P097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Sd197</strain>
            <plasmid evidence="6">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CcdB toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001159860.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406098.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Z8"/>
    <dbReference type="EnsemblBacteria" id="ABB64610">
        <property type="protein sequence ID" value="ABB64610"/>
        <property type="gene ID" value="SDY_P097"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P097"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5648"/>
    <dbReference type="HOGENOM" id="CLU_158043_2_0_6"/>
    <dbReference type="OMA" id="RLMTTDM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008657">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006276">
        <property type="term" value="P:plasmid maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002712">
        <property type="entry name" value="CcdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01845">
        <property type="entry name" value="CcdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="101" mass="11737" checksum="8A0C2D11F9234719" modified="2005-12-06" version="1">MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEVADLSHRENDIKNAINLMFWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q327D2</accession>
    <name>Q327D2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS629 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406064.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327D2"/>
    <dbReference type="EnsemblBacteria" id="ABB64575">
        <property type="protein sequence ID" value="ABB64575"/>
        <property type="gene ID" value="SDY_P062"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P062"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5610"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_0_6"/>
    <dbReference type="OMA" id="TIEMARW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="125"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="296" mass="33793" checksum="AA84596CEBC66DC1" modified="2005-12-06" version="1">MMPLLDKLREQYGVGPLCSELHIAPSTYYHCQQQRHHPDKRSARAQRDDWLKKEIQRVYDENHKVYGVRKVWRQLLREGIRVARCTVARLMAVMGLAGVLRGKKVRTTISRKAVAAGDRVNRQFVAERPDQLWVADFTYVSTWQGFVYVAFIIDVFAGYIVGWRVSSSMETTFVLDALEQALWARRPSGTVHHSDKGSQYVSLAYTQRLKEAGLLASTGSTGDSYDNAMAESINGLYKAEVIHRKSWKNRAEVELATLTWVDWYNNRRLLERLGHIPPAEAEKAYYASIGNDDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q327E2</accession>
    <name>Q327E2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406054.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327E2"/>
    <dbReference type="EnsemblBacteria" id="ABB64566">
        <property type="protein sequence ID" value="ABB64566"/>
        <property type="gene ID" value="SDY_P053"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P053"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5597"/>
    <dbReference type="HOGENOM" id="CLU_2182169_0_0_6"/>
    <dbReference type="OMA" id="RIMRPCT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="109" mass="12530" checksum="0BB7240F67C725E5" modified="2005-12-06" version="1">MGNKNDVMDARAIWMAVQQPGKEIAVKTEEQQSVLVLHRTRMQLVKFRTAQINALHGTLLEFGETIHKGRAAMEREFPEALERMKERLPPYLITVLENQYMNRPGNPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Z1</accession>
    <name>Q327Z1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405855.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Z1"/>
    <dbReference type="STRING" id="300267.SDY_4488"/>
    <dbReference type="EnsemblBacteria" id="ABB64364">
        <property type="protein sequence ID" value="ABB64364"/>
        <property type="gene ID" value="SDY_4488"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4488"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5299"/>
    <dbReference type="HOGENOM" id="CLU_916764_0_0_6"/>
    <dbReference type="OMA" id="CRNINGE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="315" mass="36443" checksum="42827BEB817296F3" modified="2005-12-06" version="1">MLDAYDADEISETSYINKLRRLAQREPDFIDIHAHLAYAFLEQNAPRKALNAALKGLAAGNRIIPESFCGEIIWMHPENRPYLRALYAAILANVHLQRHQDAVMLTDKILAYNPEDNQGARWLLGSELLRTGDHERAFSVLKEHADEFSPYWYELGLLHFLNGEHVKAATAFRHGFATNTYIAEMLCGNLHPFPLAVWHDFSGSLDTAEDYYATYSPLWGQYPEALLFVNWLYNHSSVLHERAEIIKCAEMLIQEDDFEICESILRQQEHLWKRIDKTLSEEIVQKCRNMNGEYIWPWILPFSAAGMKHSSIQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q328E5</accession>
    <name>Q328E5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328E5"/>
    <dbReference type="EnsemblBacteria" id="ABB64310">
        <property type="protein sequence ID" value="ABB64310"/>
        <property type="gene ID" value="SDY_4423"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4423"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="7706" checksum="C2C0185FB433FBF9" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITVYAVMLPISRTCVFQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q328L4</accession>
    <name>GHRB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxylate/hydroxypyruvate reductase B</fullName>
            <ecNumber evidence="1">1.1.1.79</ecNumber>
            <ecNumber evidence="1">1.1.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ghrB</name>
        <name type="ordered locus">SDY_4350</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycolate + NADP(+) = glyoxylate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.79"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:17905"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16659"/>
            <dbReference type="ChEBI" id="CHEBI:17180"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.81"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16659"/>
            <dbReference type="ChEBI" id="CHEBI:17180"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.81"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB64241" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.1.1.79" evidence="1"/>
    <dbReference type="EC" id="1.1.1.81" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64241.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000805012.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405732.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328L4"/>
    <dbReference type="SMR" id="Q328L4"/>
    <dbReference type="STRING" id="300267.SDY_4350"/>
    <dbReference type="EnsemblBacteria" id="ABB64241">
        <property type="protein sequence ID" value="ABB64241"/>
        <property type="gene ID" value="SDY_4350"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4350"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5134"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:glycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01667">
        <property type="entry name" value="2_Hacid_dh_C_GhrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023756">
        <property type="entry name" value="Glyo/OHPyrv_Rdtase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000348401" description="Glyoxylate/hydroxypyruvate reductase B">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="324" mass="35463" checksum="ABE65CB9CC0D4F1D" modified="2008-09-02" version="2">MKPSVILYKALPDDLLQRLQEHFTVHQVANLSPQTVDQNAAIFAEAEGLLGSNENVDAALLEKMPRLRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLMALVLSTARRVVEVAERVKAGEWTASIGPDWYGTDVYHKTLGIVGMGRIGMALAQRAHFGFNMPILYNARRHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETYHLFGAEQFAKMKSSAIFINAGRGPVVDENALIAALQKGEIHAAGLDVFEQEPLSVDSPLLSMANVVAVPHIGSATHETRYGMAACAVDNLIDALQGKVEKNCVNPHVAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q328M0</accession>
    <name>SYGA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="1">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyQ</name>
        <name type="ordered locus">SDY_4344</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001168544.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405726.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328M0"/>
    <dbReference type="SMR" id="Q328M0"/>
    <dbReference type="STRING" id="300267.SDY_4344"/>
    <dbReference type="EnsemblBacteria" id="ABB64235">
        <property type="protein sequence ID" value="ABB64235"/>
        <property type="gene ID" value="SDY_4344"/>
    </dbReference>
    <dbReference type="GeneID" id="67417204"/>
    <dbReference type="KEGG" id="sdy:SDY_4344"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5128"/>
    <dbReference type="HOGENOM" id="CLU_057066_1_0_6"/>
    <dbReference type="OMA" id="SYYQFQV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00733">
        <property type="entry name" value="GlyRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00254">
        <property type="entry name" value="Gly_tRNA_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002310">
        <property type="entry name" value="Gly-tRNA_ligase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02091">
        <property type="entry name" value="tRNA-synt_2e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01044">
        <property type="entry name" value="TRNASYNTHGA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00388">
        <property type="entry name" value="glyQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000047494" description="Glycine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00254"/>
        </source>
    </evidence>
    <sequence length="303" mass="34716" checksum="8C22062079FD4DDA" modified="2005-12-06" version="1">MQKFDTRTFQGLILTLQDYWARQGCTIVQPLDMEVGAGTSHPMTCLRALGPEPMAAAYVQPSRRPTDGRYGENPNRLQHYYQFQVVIKPSPDNIQELYLGSLKELGMDPTIHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPVTGEITYGLERLAMYIQGVDSVYDLVWSDGPLGKTTYGDVFHQNEVEQSTYNFEYADVDFLFTCFEQYEKEAQQLLALENPLPLPAYERILKAAHSFNLLDARKAISVTERQRYILRIRTLTKAVAEAYYASREALGFPMCNKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q328N8</accession>
    <name>Q328N8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Repressor of aceBA operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iclR</name>
        <name evidence="5" type="ordered locus">SDY_4323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328N8"/>
    <dbReference type="STRING" id="300267.SDY_4323"/>
    <dbReference type="EnsemblBacteria" id="ABB64217">
        <property type="protein sequence ID" value="ABB64217"/>
        <property type="gene ID" value="SDY_4323"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4323"/>
    <dbReference type="HOGENOM" id="CLU_062618_7_1_6"/>
    <dbReference type="OMA" id="EPDRLHR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="100"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="287" mass="31285" checksum="0E3BDACF42A1B147" modified="2005-12-06" version="1">MKMISTIQKKETVMVAPIPAKRGRKPAVATAPATGQVQSLTRGLKLLEWIAESNGSVALTELAQQAGLPNSTTHRLLTTMQQQGFVRQVGELGHWAIGAHAFMVGSSFLQSRNLLAIVHPILRNLMEESGETVNMAVLDQSDHEAIIIDQVQCTHLMRMSAPIGGKLPMHASGAGKVFLAQLSEEQVTKLLHRKGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDNEEHALGLRCLAACIFDEHREPFAAISISGPISRITDDRVTEFGAMVIKAAKEVTLAYGGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q328V0</accession>
    <name>Q328V0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Soluble cytochrome b562</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cybC</name>
        <name evidence="7" type="ordered locus">SDY_4254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Electron-transport protein of unknown function.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="5">Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b562 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328V0"/>
    <dbReference type="STRING" id="300267.SDY_4254"/>
    <dbReference type="EnsemblBacteria" id="ABB64155">
        <property type="protein sequence ID" value="ABB64155"/>
        <property type="gene ID" value="SDY_4254"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4254"/>
    <dbReference type="HOGENOM" id="CLU_140814_1_1_6"/>
    <dbReference type="OMA" id="ATRNENH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009155">
        <property type="entry name" value="Cyt_b562"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010980">
        <property type="entry name" value="Cyt_c/b562"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07361">
        <property type="entry name" value="Cytochrom_B562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000029">
        <property type="entry name" value="Cytochrome_b562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47175">
        <property type="entry name" value="SSF47175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000029-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11095" checksum="E4341C11B05578B8" modified="2005-12-06" version="1">METLNDNLKVVEKADNAAQVKDALTKMRAAALDAQKATPPKLEGKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEVQAAAEQLKTTRNSYHKKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q328W0</accession>
    <name>Q328W0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328W0"/>
    <dbReference type="EnsemblBacteria" id="ABB64145">
        <property type="protein sequence ID" value="ABB64145"/>
        <property type="gene ID" value="SDY_4244"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4244"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="74" mass="8263" checksum="09F599F07AED12FF" modified="2005-12-06" version="1">MAVTAAKSVMAFRVMTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITIDRKKGFAEAIKNAVMLPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q329D0</accession>
    <name>Q329D0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative 6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_4168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000160093.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405566.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329D0"/>
    <dbReference type="STRING" id="300267.SDY_4168"/>
    <dbReference type="CAZy" id="GH4">
        <property type="family name" value="Glycoside Hydrolase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64075">
        <property type="protein sequence ID" value="ABB64075"/>
        <property type="gene ID" value="SDY_4168"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4168"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4900"/>
    <dbReference type="HOGENOM" id="CLU_045951_2_0_6"/>
    <dbReference type="OMA" id="KYPMREK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_4C" evidence="8">
        <location>
            <begin position="195"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="440" mass="49301" checksum="1372308667FA9EBE" modified="2005-12-06" version="1">MTKFSVVVAGGGSTFTPGIVLMLLANQDRFPLRALKFYDNDGARQEVIAEACKVILKEKAPDIAFSYTTDPEVAFSDVDFVMAHIRVGKYPMRELDEKIPLRHGVIGQETCGPGGIAYGMRSIGGVLELVDYMEKYSPNAWMLNYSNPAAIVAEATRRLRPNAKILNICDMPIGIESRMAQIVGLQDRKQMRVRYYGLNHFGWWTSIEDLQGNDLMPQLRQYVSKHGYVPPQQGTHTEASWNDTYAKARDVQALDPDTLPNTYLKYYLFPDYVVQHSNPEHTRANEVMEHREKQVFDACRAITAAGNSAAGKLEIDEHASYIVDLAAAIAFNTQERMLLIVPNNGAIHNFDDEAMVEIPCLVGHNGPELLVVGDIPQFQKGLMSQQVAVEKLVVDAWEQRSYQHLWQAITLSKTVPSASVAKAILDELLEANKAYWPELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q329I0</accession>
    <name>Q329I0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phnF</name>
        <name evidence="2" type="ordered locus">SDY_4114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378930.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405516.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329I0"/>
    <dbReference type="STRING" id="300267.SDY_4114"/>
    <dbReference type="EnsemblBacteria" id="ABB64025">
        <property type="protein sequence ID" value="ABB64025"/>
        <property type="gene ID" value="SDY_4114"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4114"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4838"/>
    <dbReference type="HOGENOM" id="CLU_063236_2_2_6"/>
    <dbReference type="OMA" id="HRPDKFR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012702">
        <property type="entry name" value="CP_lyase_PhnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02325">
        <property type="entry name" value="C_P_lyase_phnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="241" mass="27595" checksum="2FC6BDFDD71DB6C3" modified="2005-12-06" version="1">MHLSTHPTSYPTCYQEIAAKLEQELRQHYRCGDYLPAEQQLAARFEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPFDYPLNAQARFSQNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFADLTLWPTLQRFDSGSLHDFLREQTGIALRRSQTRINARRAQAKECQRLEIPNMSPLLCVRTLNHRDGESSPAEYSVSLTRADMIEFTMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q329J4</accession>
    <name>Q329J4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ARAC-type regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">adiY</name>
        <name evidence="3" type="ordered locus">SDY_4097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001217059.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405502.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329J4"/>
    <dbReference type="SMR" id="Q329J4"/>
    <dbReference type="STRING" id="300267.SDY_4097"/>
    <dbReference type="EnsemblBacteria" id="ABB64011">
        <property type="protein sequence ID" value="ABB64011"/>
        <property type="gene ID" value="SDY_4097"/>
    </dbReference>
    <dbReference type="GeneID" id="66671973"/>
    <dbReference type="KEGG" id="sdy:SDY_4097"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4820"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_4_6"/>
    <dbReference type="OMA" id="MIIRATQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="149"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="253" mass="29021" checksum="9A7DE2AA6E6BFF93" modified="2005-12-06" version="1">MRICSDQPCIVLLTEKDVWIRVNGKEPISLKANHMALLNCENNIIDVSSLNNTLVAHISHDIIKDYLRFLNKDLSQIPVWQRSATPILTLPCLTPDVFRVAAQHSMMPAETESEKERTRALLFTVLSRFLDSKKFLSLMMYMLRNCVSDSVYQIIESDIHKDWNLSMVASCLCLSPSLLKKKLKSENTSYSQIITTCRMRYAVNELMMDGKNISQVSQSCGYNSTSYFISVFKDFYGMTPLHYVSQHRERTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q329J7</accession>
    <name>Q329J7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Biodegradative arginine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adiA</name>
        <name evidence="6" type="ordered locus">SDY_4094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405499.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329J7"/>
    <dbReference type="STRING" id="300267.SDY_4094"/>
    <dbReference type="EnsemblBacteria" id="ABB64008">
        <property type="protein sequence ID" value="ABB64008"/>
        <property type="gene ID" value="SDY_4094"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4094"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4817"/>
    <dbReference type="HOGENOM" id="CLU_014292_3_0_6"/>
    <dbReference type="OMA" id="RVDTWNL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00615">
        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005308">
        <property type="entry name" value="OKR_de-COase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011193">
        <property type="entry name" value="Orn/lys/arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03709">
        <property type="entry name" value="OKR_DC_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009393">
        <property type="entry name" value="Orn_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00703">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="5">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR009393-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="756" mass="84555" checksum="4C6F1DCE0FE9514D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q329L5</accession>
    <name>Q329L5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase, msDNA specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329L5"/>
    <dbReference type="STRING" id="300267.SDY_4072"/>
    <dbReference type="EnsemblBacteria" id="ABB63990">
        <property type="protein sequence ID" value="ABB63990"/>
        <property type="gene ID" value="SDY_4072"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4072"/>
    <dbReference type="HOGENOM" id="CLU_1649660_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03487">
        <property type="entry name" value="RT_Bac_retron_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="169" mass="19289" checksum="15A9C6C2A2E09B2A" modified="2005-12-06" version="1">MVLTPDYLLKTVQRNILKNVLSQFPLSPFATAYRPGCPIVSSAQPHCQQPQILKLDIENFFDSISWLQVWRVFRQAQLPRNVVTMLTWICCYNDALPQGAPTSPAISNLVMRCFDERIGEWCQARGITYTRYCDNMTFSGHFNARQVKNKVCGLLAELGLSLNQRKSCL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q329M0</accession>
    <name>RL28_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmB</name>
        <name type="ordered locus">SDY_4067</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000091955.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405476.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329M0"/>
    <dbReference type="SMR" id="Q329M0"/>
    <dbReference type="STRING" id="300267.SDY_4067"/>
    <dbReference type="EnsemblBacteria" id="ABB63985">
        <property type="protein sequence ID" value="ABB63985"/>
        <property type="gene ID" value="SDY_4067"/>
    </dbReference>
    <dbReference type="GeneID" id="64292959"/>
    <dbReference type="GeneID" id="67417639"/>
    <dbReference type="KEGG" id="sdy:SDY_4067"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4783"/>
    <dbReference type="HOGENOM" id="CLU_064548_3_1_6"/>
    <dbReference type="OMA" id="FEPNLHT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000007356" description="50S ribosomal protein L28">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <sequence length="78" mass="9006" checksum="2616ADB10772A57C" modified="2005-12-06" version="1">MSRVCQVTGKRPVTGNNRSHALNATKRRFLPNLHSHRFWVESEKRFVTLRVSAKGMRVIDKKGIDTVLAELRARGEKY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q329P5</accession>
    <name>SECB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-export protein SecB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secB</name>
        <name type="ordered locus">SDY_4042</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000003382.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405451.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329P5"/>
    <dbReference type="SMR" id="Q329P5"/>
    <dbReference type="STRING" id="300267.SDY_4042"/>
    <dbReference type="EnsemblBacteria" id="ABB63960">
        <property type="protein sequence ID" value="ABB63960"/>
        <property type="gene ID" value="SDY_4042"/>
    </dbReference>
    <dbReference type="GeneID" id="66672493"/>
    <dbReference type="KEGG" id="sdy:SDY_4042"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4757"/>
    <dbReference type="HOGENOM" id="CLU_111574_1_0_6"/>
    <dbReference type="OMA" id="CPNVLFP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00821">
        <property type="entry name" value="SecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003708">
        <property type="entry name" value="SecB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035958">
        <property type="entry name" value="SecB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36918">
        <property type="entry name" value="PTHR36918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02556">
        <property type="entry name" value="SecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01594">
        <property type="entry name" value="SECBCHAPRONE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54611">
        <property type="entry name" value="SSF54611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00809">
        <property type="entry name" value="secB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000062528" description="Protein-export protein SecB">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00821"/>
        </source>
    </evidence>
    <sequence length="155" mass="17291" checksum="F5041AEF548CBF50" modified="2005-12-06" version="1">MSEQNNTEMTFQIQRIYTKDISFEAPNAPHVFQKDWQPEVKLDLDTASTQLADDVYEVVLRVTVTASLGEETAFLCEVQQGGIFSIAGIEGTQMAHCLGAYCPNILFPYARECITSMVSRGTFPQLNLAPVNFDALFMNYLQQQAGEGTEEHQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Q3</accession>
    <name>Q329Q3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405443.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Q3"/>
    <dbReference type="STRING" id="300267.SDY_4034"/>
    <dbReference type="EnsemblBacteria" id="ABB63952">
        <property type="protein sequence ID" value="ABB63952"/>
        <property type="gene ID" value="SDY_4034"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4034"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4749"/>
    <dbReference type="HOGENOM" id="CLU_002363_1_0_6"/>
    <dbReference type="OMA" id="QTRDRNQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008640">
        <property type="entry name" value="Adhesin_Head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008635">
        <property type="entry name" value="Coiled_stalk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05658">
        <property type="entry name" value="YadA_head"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05662">
        <property type="entry name" value="YadA_stalk"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="2">
        <location>
            <begin position="164"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="2">
        <location>
            <begin position="262"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="2">
        <location>
            <begin position="360"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="2">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="2">
        <location>
            <begin position="559"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="630"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="2">
        <location>
            <begin position="715"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="790"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="835" mass="83731" checksum="815C67A082250D00" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q329R7</accession>
    <name>Q329R7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS1294 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000198555.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405429.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329R7"/>
    <dbReference type="EnsemblBacteria" id="ABB63938">
        <property type="protein sequence ID" value="ABB63938"/>
        <property type="gene ID" value="SDY_4020"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4020"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4733"/>
    <dbReference type="HOGENOM" id="CLU_038153_0_0_6"/>
    <dbReference type="OMA" id="VCYAQIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007069">
        <property type="entry name" value="Transposase_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026889">
        <property type="entry name" value="Zn_Tnp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04986">
        <property type="entry name" value="Y2_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14319">
        <property type="entry name" value="Zn_Tnp_IS91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS91" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="402" mass="45951" checksum="C958DC5227262F47" modified="2005-12-06" version="1">MTRSGGDFQPRPLKRLFTTNQCWTSFLDAGGLRDIEVEAVTKMLACGTRILGVKEYNCDKPECPHVRYVTNSCGSRACPSCGKKATDLWIATQLNRLPDCDWVHLVFILPDTQWPVFESNRWLLNDVCRLAVENLLYAARKRGQEPGIFCAIHTYGRRLNWHPHVHVSVTCGGLNKHGQWKKLSFLKDAMRSRWMWNMRQRLLKAWSEGLAMPESLSHITTESQRRSLVLKAGGKYWHVYMSKKTAGGRNTARYLGRYLKKPPIAASRLAHYNGGASLSFRYLDHKTGETATETLTQRELVARLKQHIPEKFFKMVRYFGFLANRVCGEKLPQVYRALGMDKPAPVAKVCYAQMVKQFLSRDPFECVLCGGRMVYRRAIAGLNVEGLKKNARDISLLRYMPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q329S9</accession>
    <name>RSMG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="1">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmG</name>
        <name type="ordered locus">SDY_4008</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(527) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42732"/>
            <dbReference type="Rhea" id="RHEA-COMP:10209"/>
            <dbReference type="Rhea" id="RHEA-COMP:10210"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.170"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.170" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000932830.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405417.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329S9"/>
    <dbReference type="SMR" id="Q329S9"/>
    <dbReference type="STRING" id="300267.SDY_4008"/>
    <dbReference type="EnsemblBacteria" id="ABB63926">
        <property type="protein sequence ID" value="ABB63926"/>
        <property type="gene ID" value="SDY_4008"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4008"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4720"/>
    <dbReference type="HOGENOM" id="CLU_065341_2_2_6"/>
    <dbReference type="OMA" id="ICFPHLH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000010208" description="Ribosomal RNA small subunit methyltransferase G">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <sequence length="207" mass="23481" checksum="20524ABDFAF46BB7" modified="2005-12-06" version="1">MLNKLSLLLKDAGIPLTDHQKNQLIAYVNMLHKWNKAYNLTSVRDPNEMLVRHILDSIVVAPYLQGERFIDVGTGPGLPGIPLSIVRPEAHFTLLDSLGKRVRFLRQVQHELKLENIEPVQSRVEEFPSEPPFDGVISRAFASLNDMVSWCHHLPGEQGRFYALKGQMPEDEIALLHEEYQVESVVKLQVPALDGERHLVVIKANKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q329X9</accession>
    <name>Q329X9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="1">4.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hemD</name>
        <name evidence="3" type="ordered locus">SDY_3942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydroxymethylbilane = H2O + uroporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000026074.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405367.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329X9"/>
    <dbReference type="STRING" id="300267.SDY_3942"/>
    <dbReference type="EnsemblBacteria" id="ABB63876">
        <property type="protein sequence ID" value="ABB63876"/>
        <property type="gene ID" value="SDY_3942"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3942"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4653"/>
    <dbReference type="HOGENOM" id="CLU_011276_9_4_6"/>
    <dbReference type="OMA" id="HPRIAQA"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042">
        <property type="entry name" value="PTHR38042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="2">
        <location>
            <begin position="14"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="246" mass="27798" checksum="008F754602925D4D" modified="2005-12-06" version="1">MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPTYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQSREVTTVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRALQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A13</accession>
    <name>UBIB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable protein kinase UbiB</fullName>
            <ecNumber evidence="1">2.7.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ubiquinone biosynthesis protein UbiB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiB</name>
        <name type="ordered locus">SDY_3908</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text>Cofactor biosynthesis; ubiquinone biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC1 family. UbiB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000187530.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405333.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A13"/>
    <dbReference type="SMR" id="Q32A13"/>
    <dbReference type="STRING" id="300267.SDY_3908"/>
    <dbReference type="EnsemblBacteria" id="ABB63842">
        <property type="protein sequence ID" value="ABB63842"/>
        <property type="gene ID" value="SDY_3908"/>
    </dbReference>
    <dbReference type="GeneID" id="66672257"/>
    <dbReference type="KEGG" id="sdy:SDY_3908"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4616"/>
    <dbReference type="HOGENOM" id="CLU_006533_0_0_6"/>
    <dbReference type="OMA" id="RRDYKRV"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010795">
        <property type="term" value="P:regulation of ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13972">
        <property type="entry name" value="UbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00414">
        <property type="entry name" value="UbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010232">
        <property type="entry name" value="UbiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045308">
        <property type="entry name" value="UbiB_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01982">
        <property type="entry name" value="UbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="chain" id="PRO_1000050065" description="Probable protein kinase UbiB">
        <location>
            <begin position="1"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00414"/>
        </source>
    </evidence>
    <sequence length="546" mass="63203" checksum="D66C8AD50C05B4EC" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A50</accession>
    <name>Q32A50_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405296.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A50"/>
    <dbReference type="STRING" id="300267.SDY_3863"/>
    <dbReference type="EnsemblBacteria" id="ABB63805">
        <property type="protein sequence ID" value="ABB63805"/>
        <property type="gene ID" value="SDY_3863"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3863"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4567"/>
    <dbReference type="HOGENOM" id="CLU_052486_3_0_6"/>
    <dbReference type="OMA" id="PGPWDDC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="243" mass="27340" checksum="A7E3F73E97CDA242" modified="2005-12-06" version="1">MKTERKNEHYLALQQAFDAPWPGPVGELVTLEKGNIHLQIYPHDGARITSLKAFGSEVLRQWQPQRRAFQYGCFPMVPWAGRLGNATLNAGGQCYSLPANKPPHALHGMACYSTWEIIDKTADSLTLRMPLASPWPWQGEVIQTFLLENDALVLQLEVHSYADTFPASAGWHPWFAKKLTPQNTESLQVLFDADWQEEAGSDELPTGNRISPQAGPWDDCFGFYDGVKVKLLWPGKLAMTMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A69</accession>
    <name>Q32A69_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhamnulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rhaB</name>
        <name evidence="3" type="ordered locus">SDY_3842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000144061.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405277.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A69"/>
    <dbReference type="STRING" id="300267.SDY_3842"/>
    <dbReference type="EnsemblBacteria" id="ABB63786">
        <property type="protein sequence ID" value="ABB63786"/>
        <property type="gene ID" value="SDY_3842"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3842"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4538"/>
    <dbReference type="HOGENOM" id="CLU_039395_0_0_6"/>
    <dbReference type="OMA" id="MPDLFNY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="151"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="387" mass="42522" checksum="9D3A44ED06D5DEB2" modified="2005-12-06" version="1">MTFRNCVAVDLGASSGRVMLARYERECRSLTLREIHRFNNGLHSQNGYVTWDVDSLESAIRLGLNKACEEGIRIDSIGIDTWGVDFVLLDQQGQRVGLPVAYRDSRTDGLMAQAQQQLGKRDIYQRSGIQFLPFNTASAVIASPLNGSRAAYLSSGTWSLMGFESQTPFTNDTALAANITNEGGAEGRYRVLKNIMGLWLLQRVLQERQINDLPALIAATQALPACRFIINPNDDRFINPDEMCSEIQAACRETAQPIPESDAELARCIFDSLALLYADVLHELAQLRGEDFSQLHIVGGGCQNTLLNQLCADACGIRVIAGPVEASTLGNIGIQLMTLDELNNVDDFHQVVSTTANLTTFTPNPDSEIAHYVAQLHSTRQTKELCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A78</accession>
    <name>Q32A78_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yiiO</name>
        <name evidence="6" type="ordered locus">SDY_3833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpxP/Spy family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A78"/>
    <dbReference type="STRING" id="300267.SDY_3833"/>
    <dbReference type="EnsemblBacteria" id="ABB63777">
        <property type="protein sequence ID" value="ABB63777"/>
        <property type="gene ID" value="SDY_3833"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3833"/>
    <dbReference type="HOGENOM" id="CLU_124352_2_1_6"/>
    <dbReference type="OMA" id="NERMQEC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09916">
        <property type="entry name" value="CpxP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012899">
        <property type="entry name" value="LTXXQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07813">
        <property type="entry name" value="LTXXQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034445">
        <property type="entry name" value="CpxP_Spy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220986" evidence="5">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="167" mass="19096" checksum="CD9571844E1604F6" modified="2005-12-06" version="1">MMRIVTAAVMASTLAVSSLSHAAEVGSGDNWHPGEELTQRSTQSHMFDGISLTEHQRQQMRDLMQQARHEQPPVNVSELETMHRLVTAENFDENAVRAQAEKMANEQIARQVEMAKVRNQMYRLLTPEQQAVLNEKHQQRMEQLRDVTQWQKSSSLKLLSSSNSRSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A79</accession>
    <name>FIEF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cation-efflux pump FieF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fieF</name>
        <name type="ordered locus">SDY_3832</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+). May be involved in zinc and iron detoxification by efflux.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:28739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001076742.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405267.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A79"/>
    <dbReference type="SMR" id="Q32A79"/>
    <dbReference type="STRING" id="300267.SDY_3832"/>
    <dbReference type="EnsemblBacteria" id="ABB63776">
        <property type="protein sequence ID" value="ABB63776"/>
        <property type="gene ID" value="SDY_3832"/>
    </dbReference>
    <dbReference type="GeneID" id="66672177"/>
    <dbReference type="KEGG" id="sdy:SDY_3832"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4526"/>
    <dbReference type="HOGENOM" id="CLU_013430_3_0_6"/>
    <dbReference type="OMA" id="IEMHLIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01425">
        <property type="entry name" value="Cation_efflux_FieF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023783">
        <property type="entry name" value="Cation_efflux_FieF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0410">Iron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0864">Zinc transport</keyword>
    <feature type="chain" id="PRO_1000024329" description="Cation-efflux pump FieF">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01425"/>
        </source>
    </evidence>
    <sequence length="300" mass="32927" checksum="A9ECC4D6ED9A750F" modified="2005-12-06" version="1">MNQSYGRLVSRAAIAATAMASLLLLIKIFAWWYTGSVSILAALVDSLVDIGASLTNLLVVRYSLQPADDNHSFGHGKAESLAALAQSMFISGSALFLFLTGIQHLISPTPMTDPGVGVIVTIVALICTIILVSFQRWVVRRTQSQAVRADMLHYQSDVMMNGAILLALGLSWYGWHRADALFALGIGIYILYSALRMGYEAVQSLLDRALPDEERQEIIDIVTSWPGVSGAHDLRTRQSGPTRFIQIHLEMEDSLPLVQAHMVADQVEQAILRRFPGSDVIIHQDPCSVVPREGKRSMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A85</accession>
    <name>Q32A85_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yiiQ</name>
        <name evidence="2" type="ordered locus">SDY_3825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000765796.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405261.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A85"/>
    <dbReference type="STRING" id="300267.SDY_3825"/>
    <dbReference type="EnsemblBacteria" id="ABB63770">
        <property type="protein sequence ID" value="ABB63770"/>
        <property type="gene ID" value="SDY_3825"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3825"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4517"/>
    <dbReference type="HOGENOM" id="CLU_103682_0_0_6"/>
    <dbReference type="OMA" id="GQFREKY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009918">
        <property type="entry name" value="DUF1454"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07305">
        <property type="entry name" value="DUF1454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220972" evidence="1">
        <location>
            <begin position="24"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="199" mass="21751" checksum="7670E783D52EA90F" modified="2005-12-06" version="1">MKLGCTLFFLLCSALTVTTTAHAQTPDTATTAPYLLAGAPTFDLSISQFREDFNSQNPSLPLNEFRAIDSSPDKANLTRAASKINENLYASTALERGTLKIKSIQMTWLPIQGPEQKAAKAKAQEYMAAVIRTLTPLMTKTQSQKKLQSLLTAGKNKRYYTETEGALRYVVADNGEKGLTFAVEPIKLALSESLEGLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AM0</accession>
    <name>Q32AM0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor GreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Transcript cleavage factor GreB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">greB</name>
        <name evidence="7" type="ordered locus">SDY_3670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GreA/GreB family. GreB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000856744.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405126.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AM0"/>
    <dbReference type="SMR" id="Q32AM0"/>
    <dbReference type="STRING" id="300267.SDY_3670"/>
    <dbReference type="EnsemblBacteria" id="ABB63635">
        <property type="protein sequence ID" value="ABB63635"/>
        <property type="gene ID" value="SDY_3670"/>
    </dbReference>
    <dbReference type="GeneID" id="67417033"/>
    <dbReference type="KEGG" id="sdy:SDY_3670"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4355"/>
    <dbReference type="HOGENOM" id="CLU_101379_3_0_6"/>
    <dbReference type="OMA" id="DQIFFGA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00930">
        <property type="entry name" value="GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006358">
        <property type="entry name" value="Tscrpt_elong_fac_GreB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01461">
        <property type="entry name" value="greB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="5">
        <location>
            <begin position="81"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="158" mass="18545" checksum="28B57554EAAB58DE" modified="2005-12-06" version="1">MKTPLVTREGYEKLKQELNYLWREERPEVTKKVTWAASLGDRSENADYQYNKKRLREIDRRVRYLTKCMENLKIVDYSPQQEGKVFFGAWVEIENDDGVTHRFRIVGYDEIFGRKDYISIDSPMARALLKKEVGDLAVVNTPAGEASWYVNAIEYVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AS1</accession>
    <name>Q32AS1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ftsX</name>
        <name evidence="13" type="ordered locus">SDY_3613</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a membrane-associated complex with FtsE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001042003.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405075.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AS1"/>
    <dbReference type="SMR" id="Q32AS1"/>
    <dbReference type="STRING" id="300267.SDY_3613"/>
    <dbReference type="EnsemblBacteria" id="ABB63584">
        <property type="protein sequence ID" value="ABB63584"/>
        <property type="gene ID" value="SDY_3613"/>
    </dbReference>
    <dbReference type="GeneID" id="66672654"/>
    <dbReference type="KEGG" id="sdy:SDY_3613"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4289"/>
    <dbReference type="HOGENOM" id="CLU_073546_0_0_6"/>
    <dbReference type="OMA" id="ETGIMRL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00439">
        <property type="entry name" value="ftsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="12">
        <location>
            <begin position="110"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="352" mass="38544" checksum="C006ED56043739AE" modified="2005-12-06" version="1">MNKRDAINHIRQFGGRLDRFRKSVGGSGDGGRNAPKRAKSSPKPVNRKTNVFNEQVRYAFHGALQDLKSKPFATFLTVMVIAISLTLPSVCYMVYKNVNQAATQYYPSPQITVYLQKTLDDDAAAGVVAQLQAEQGVEKVNYLSREDALGEFRNWSGFGGALDMLEENPLPAVAVVIPKLDFQGTESLNTLRDRITQINGIDEVRMDDSWFARLAALTGLVGRVSAMIGVLMVAAVFLVIGNSVRLSIFARRDSINVQKLIGATDGFILRPFLYGGALLGFSGALLSLILSEILVLRLSSAVAEVAQVFGTKFDINGLSFDECLLLLLVCSMIGWVAAWLATVQHLRHFTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AZ9</accession>
    <name>Q32AZ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nirC</name>
        <name evidence="7" type="ordered locus">SDY_3529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FNT transporter (TC 2.A.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000255660.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404997.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AZ9"/>
    <dbReference type="STRING" id="300267.SDY_3529"/>
    <dbReference type="EnsemblBacteria" id="ABB63506">
        <property type="protein sequence ID" value="ABB63506"/>
        <property type="gene ID" value="SDY_3529"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3529"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4183"/>
    <dbReference type="HOGENOM" id="CLU_036896_2_1_6"/>
    <dbReference type="OMA" id="SIRPLVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00790">
        <property type="entry name" value="fnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01005">
        <property type="entry name" value="FORMATE_NITRITE_TP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="268" mass="28528" checksum="CC56788AE8F8655B" modified="2005-12-06" version="1">MVTDTINKCAANAARIARLSANNPLGFWVSSAMAGAYVGLGIILIFTLGNLLDPSVRPLVMGATFGIALTLVIIAGSELFTGHTMFLTFGVKAGTISHGQMWAILPQTWLGNLVGSVFVAMLYSWGGGSLLPVDTSIVHSVALAKTTAPAMVLFFKGALCNWLVCLAIWMALRTEGAAKFIAIWWCLLAFIASGYEHSIANMTLFALSWFGNHSEAYTLAGIGHNLLWVTLGNTLSGAVFMGLGYWYATPKANRPVADKFNQTETAAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B21</accession>
    <name>TUSD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase TusD</fullName>
            <ecNumber evidence="1">2.8.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA 2-thiouridine synthesizing protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tusD</name>
        <name type="ordered locus">SDY_3506</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DsrE/TusD family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001209708.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404975.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B21"/>
    <dbReference type="SMR" id="Q32B21"/>
    <dbReference type="STRING" id="300267.SDY_3506"/>
    <dbReference type="EnsemblBacteria" id="ABB63484">
        <property type="protein sequence ID" value="ABB63484"/>
        <property type="gene ID" value="SDY_3506"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3506"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4160"/>
    <dbReference type="HOGENOM" id="CLU_132095_0_0_6"/>
    <dbReference type="OMA" id="PQDDRNI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00390">
        <property type="entry name" value="Thiourid_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017463">
        <property type="entry name" value="Sulphur_relay_TusD/DsrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03012">
        <property type="entry name" value="sulf_tusD_dsrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000234536" description="Sulfurtransferase TusD">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00390"/>
        </source>
    </evidence>
    <sequence length="128" mass="13640" checksum="ED8A73C8D5046440" modified="2005-12-06" version="1">MRFAIVVTGPAYGTQQASSAFQFAQALIAEGHKLSSVFFYREGVYNANQLTSPASDEFDLVRGWQQLNAQHGVALNICVAAALRRGVVDETEAGRLGLASSNLQQGFTLSGLGALAEASLTCDRVVQF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-11-04" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B67</accession>
    <name>TSAC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="1">TC-AMP synthase</shortName>
            <ecNumber evidence="1">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA threonylcarbamoyladenosine biosynthesis protein TsaC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsaC</name>
        <name type="synonym">rimN</name>
        <name type="ordered locus">SDY_3459</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUA5 family. TsaC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378872.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404929.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B67"/>
    <dbReference type="SMR" id="Q32B67"/>
    <dbReference type="STRING" id="300267.SDY_3459"/>
    <dbReference type="EnsemblBacteria" id="ABB63438">
        <property type="protein sequence ID" value="ABB63438"/>
        <property type="gene ID" value="SDY_3459"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3459"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4112"/>
    <dbReference type="HOGENOM" id="CLU_031397_6_0_6"/>
    <dbReference type="OMA" id="LVDAFWP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01852">
        <property type="entry name" value="TsaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023535">
        <property type="entry name" value="TC-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF8">
        <property type="entry name" value="PTHR17490:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000352993" description="Threonylcarbamoyl-AMP synthase">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01852"/>
        </source>
    </evidence>
    <sequence length="190" mass="20626" checksum="83BBAA159142CAD1" modified="2005-12-06" version="1">MNNNLQGDAIAAAIDVLNEERVIAYPTEAVFGVGCDPDSETAVMRLLELKLRPVDKGLILIAANYEQLKPYIDDTMLTDAQRETIFSRWPGPVTFVFPAPATTPRWLTGRFDSLAVRVTDHPLVVALCQAYGKPLVSTSANLSGLPPCRTVDEVRAQFGAAFPVVPGETGGRLNPSEIRDALTGELFRQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BI3</accession>
    <name>DIAA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DnaA initiator-associating protein DiaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">diaA</name>
        <name type="ordered locus">SDY_3328</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. DiaA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001158034.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404813.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BI3"/>
    <dbReference type="SMR" id="Q32BI3"/>
    <dbReference type="STRING" id="300267.SDY_3328"/>
    <dbReference type="EnsemblBacteria" id="ABB63322">
        <property type="protein sequence ID" value="ABB63322"/>
        <property type="gene ID" value="SDY_3328"/>
    </dbReference>
    <dbReference type="GeneID" id="67414914"/>
    <dbReference type="KEGG" id="sdy:SDY_3328"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3981"/>
    <dbReference type="HOGENOM" id="CLU_080999_3_1_6"/>
    <dbReference type="OMA" id="DVHICVP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01157">
        <property type="entry name" value="SIS_DiaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023070">
        <property type="entry name" value="DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000065550" description="DnaA initiator-associating protein DiaA">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="34"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01157"/>
        </source>
    </evidence>
    <sequence length="196" mass="21106" checksum="F9ADFE9C0DF365A8" modified="2005-12-06" version="1">MQERIKACFTESIQTQIAAAEALPDAISRAAMTLVQSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BL5</accession>
    <name>Q32BL5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhaH</name>
        <name evidence="2" type="ordered locus">SDY_3292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000384143.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404781.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BL5"/>
    <dbReference type="EnsemblBacteria" id="ABB63290">
        <property type="protein sequence ID" value="ABB63290"/>
        <property type="gene ID" value="SDY_3292"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3292"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3934"/>
    <dbReference type="HOGENOM" id="CLU_093674_8_0_6"/>
    <dbReference type="OMA" id="WMFTLFN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008523">
        <property type="entry name" value="DUF805"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34980">
        <property type="entry name" value="PTHR34980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05656">
        <property type="entry name" value="DUF805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="121" mass="14262" checksum="6D000E703225061C" modified="2005-12-06" version="1">MDWYLKVLKNYVGFRGRARRKEYWMFILVNIIFTFVLGLLDKMLGWQRAGGEGILTTIYGILVFLPWWAVQFRRLHDTDHSAWWALLFLIPFIGWLIIIVFNCQAGTPGENRFGPDPKLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BT8</accession>
    <name>Q32BT8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA</fullName>
            <shortName evidence="2">3',5'-cyclic AMP phosphodiesterase</shortName>
            <shortName evidence="2">cAMP phosphodiesterase</shortName>
            <ecNumber evidence="2">3.1.4.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">icc</name>
        <name evidence="2" type="synonym">cpdA</name>
        <name evidence="4" type="ordered locus">SDY_3208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cyclic nucleotide phosphodiesterase class-III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.53" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000444747.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404708.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BT8"/>
    <dbReference type="SMR" id="Q32BT8"/>
    <dbReference type="STRING" id="300267.SDY_3208"/>
    <dbReference type="EnsemblBacteria" id="ABB63217">
        <property type="protein sequence ID" value="ABB63217"/>
        <property type="gene ID" value="SDY_3208"/>
    </dbReference>
    <dbReference type="GeneID" id="66673069"/>
    <dbReference type="KEGG" id="sdy:SDY_3208"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3833"/>
    <dbReference type="HOGENOM" id="CLU_070320_0_0_6"/>
    <dbReference type="OMA" id="CAWLDQH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07402">
        <property type="entry name" value="MPP_GpdQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00905">
        <property type="entry name" value="cAMP_phosphodiest_CpdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046379">
        <property type="entry name" value="cAMP_phosphodiest_CpdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026575">
        <property type="entry name" value="GpdQ/CpdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0114">cAMP</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="16"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="275" mass="30938" checksum="97696478536CFBF1" modified="2005-12-06" version="1">MESLLTLPLAGEARVRILQITDTHLFAQKHEALLGVNTWESYQAVLEAIRPHQHEFDLIVATGDLAQDQSSAAYQHFAEGIASFRAPCVWLPGNHDFQPAMYSALQDAGISPAKRVFIGEQWQILLLDSQVFGVPHGELSEFQLEWLERKLADAPERHTLLLLHHHPLPAGCSWLDQHSLRNAGELDTVLAKFPHVKYLLCGHIHQELDLDWNGRRLLATPSTCVQFKPHCSNFTLDTIAPGWRTLELHADGTLTTEVHRLADTRFQPDTASEGY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BX8</accession>
    <name>ARGP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional regulator ArgP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argP</name>
        <name type="synonym">iciA</name>
        <name type="ordered locus">SDY_3165</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls the transcription of genes involved in arginine and lysine metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000828351.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404668.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BX8"/>
    <dbReference type="SMR" id="Q32BX8"/>
    <dbReference type="STRING" id="300267.SDY_3165"/>
    <dbReference type="EnsemblBacteria" id="ABB63177">
        <property type="protein sequence ID" value="ABB63177"/>
        <property type="gene ID" value="SDY_3165"/>
    </dbReference>
    <dbReference type="GeneID" id="66673207"/>
    <dbReference type="KEGG" id="sdy:SDY_3165"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3780"/>
    <dbReference type="HOGENOM" id="CLU_063829_0_0_6"/>
    <dbReference type="OMA" id="QQWKLDS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00513">
        <property type="entry name" value="HTH_type_ArgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017685">
        <property type="entry name" value="ArgP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023490">
        <property type="entry name" value="ArgP_Gammaproteobact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03298">
        <property type="entry name" value="argP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000258615" description="HTH-type transcriptional regulator ArgP">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="297" mass="33472" checksum="8AD60B7B6661E3EF" modified="2005-12-06" version="1">MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENMFGQPLLVRTVPPRPTEQGQKLLALLRQVELLEEEWLGDEQTGSTPLLLSLAVNADSLATWLLPALAPVLADSPIRLNLQVEDETRTQERLRRGEVVGAVSIQHQALPSCLVDKLGALDYLFVSSKPFAEKYFPNGVTRSALLKAPVVAFDHLDDMHQAFLQQNFDLPPGSVPCHIVNSSEAFVQLARQGTTCCMIPHLQIEKELASGELIDLTPGLFQRRMLYWHRFAPESRMMRKVTDALLDYGHKVLRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C40</accession>
    <name>Q32C40_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative type II secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gspJ</name>
        <name evidence="9" type="ordered locus">SDY_3099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404606.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C40"/>
    <dbReference type="STRING" id="300267.SDY_3099"/>
    <dbReference type="EnsemblBacteria" id="ABB63115">
        <property type="protein sequence ID" value="ABB63115"/>
        <property type="gene ID" value="SDY_3099"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3099"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3708"/>
    <dbReference type="HOGENOM" id="CLU_093850_0_0_6"/>
    <dbReference type="OMA" id="WYYPYPE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010055">
        <property type="entry name" value="T2SS_protein-GspJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11612">
        <property type="entry name" value="T2SSJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01711">
        <property type="entry name" value="gspJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012745677" evidence="8">
        <location>
            <begin position="16"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="189" mass="21017" checksum="C7C8116436A90F80" modified="2005-12-06" version="1">MLVAIAIFASLALMAQQVTNGVTRVNSAVTGHDQKLNLMQQTMSFLTHDLTQMMPRPVRGDQGQREPALLAGAGVLASESEGMRFVRGGVVNPLMRLPRSNLLTVGYRIHDGYLERLVWPLTDAAGSVKPTMQKLIPADSLRLQFYDGTRWQESWSSVQAIPVAVRMTLHSPQWGEIERIWLLRGPQLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C93</accession>
    <name>LGT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="1">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lgt</name>
        <name type="ordered locus">SDY_3045</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000204658.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404553.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C93"/>
    <dbReference type="SMR" id="Q32C93"/>
    <dbReference type="STRING" id="300267.SDY_3045"/>
    <dbReference type="EnsemblBacteria" id="ABB63062">
        <property type="protein sequence ID" value="ABB63062"/>
        <property type="gene ID" value="SDY_3045"/>
    </dbReference>
    <dbReference type="GeneID" id="66673305"/>
    <dbReference type="KEGG" id="sdy:SDY_3045"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3650"/>
    <dbReference type="HOGENOM" id="CLU_013386_1_0_6"/>
    <dbReference type="OMA" id="TDVPWAI"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000053498" description="Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <sequence length="291" mass="33108" checksum="5F946E4E60D0112A" modified="2005-12-06" version="1">MTSSYLHFPEFDPVIFSIGPVALHWYGLMYLVGFIFAMWLATRRANRPGSGWTKNEVENLLYAGFLGVFLGGRIGYVLFYNFPQFMADPLYLFRVWDGGMSFHGGLIGVIVVMIIFARRTKRSFFQVSDFIAPLIPFGLGAGRLGNFINGELWGRVDPNFPFAMLFPGSRTEDILLLQTNPQWQSIFDTYGVLPRHPSQLYELLLEGVVLFIILNLYIRKPRPMGAVSGLFLIGYGAFRIIVEFFRQPDAQFTGAWVQYISMGQILSIPMIVAGVIMMVWAYRRSPQQHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CE7</accession>
    <name>Q32CE7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_2985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CE7"/>
    <dbReference type="STRING" id="300267.SDY_2985"/>
    <dbReference type="EnsemblBacteria" id="ABB63008">
        <property type="protein sequence ID" value="ABB63008"/>
        <property type="gene ID" value="SDY_2985"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2985"/>
    <dbReference type="HOGENOM" id="CLU_2316035_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221035" description="TPM_phosphatase domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="96" mass="10782" checksum="54AC33EA134804BE" modified="2005-12-06" version="1">MRNFIFLIAFFCSSVFATQIPVPESPKYVNDLTGTLTNSEVNTLTNQIKALTQKSHAQLVVLVVETTGDETIEQYATRVFDSWKPGDKDRDDGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CI1</accession>
    <name>Q32CI1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome oxidase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygbE</name>
        <name evidence="2" type="ordered locus">SDY_2948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001246104.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404465.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CI1"/>
    <dbReference type="STRING" id="300267.SDY_2948"/>
    <dbReference type="EnsemblBacteria" id="ABB62974">
        <property type="protein sequence ID" value="ABB62974"/>
        <property type="gene ID" value="SDY_2948"/>
    </dbReference>
    <dbReference type="GeneID" id="66673377"/>
    <dbReference type="KEGG" id="sdy:SDY_2948"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3540"/>
    <dbReference type="HOGENOM" id="CLU_172652_0_0_6"/>
    <dbReference type="OMA" id="LMLYTWP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022721">
        <property type="entry name" value="DUF3561"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12084">
        <property type="entry name" value="DUF3561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="107" mass="12017" checksum="E3ED0F889EA9C21F" modified="2005-12-06" version="1">MRNSHNITLTNNDSLTEDEETTWSLPGAVVGFISWLFALAMPMLIYGSNTLFFFIYTWPFFLALMPVAVVVGIALHSLMDGKLRYSIVFTLVTVGIMFGALFMWLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CK2</accession>
    <name>Q32CK2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrogenase maturation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypD</name>
        <name evidence="4" type="ordered locus">SDY_2926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HypD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001212969.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404444.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CK2"/>
    <dbReference type="STRING" id="300267.SDY_2926"/>
    <dbReference type="EnsemblBacteria" id="ABB62953">
        <property type="protein sequence ID" value="ABB62953"/>
        <property type="gene ID" value="SDY_2926"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2926"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3514"/>
    <dbReference type="HOGENOM" id="CLU_048562_1_0_6"/>
    <dbReference type="OMA" id="HVCGSHE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="373" mass="41305" checksum="9E0F8B0526914219" modified="2005-12-06" version="1">MRFVDEYRAPEQVMQLIEHLRERASHLSYTAERPLRIMEVCGGHTHAIFKFGLDQLLPENVEFIHGPGCPVCVLPMGRIDTCVEIASHPEVIFCTFGDAIRVPGKQGSLLQAKARGADVRIVYSPMDALKLAQENPTRKVVFFGLGFETTMPTTAITLQQAKARDVQNFYFFCQHITLIPTLRSLLEQPDNGIDAFLAPGHVSMVIGTDAYNFIASDFQRPLVVAGFEPLDLLQGVVVLVEQKIAAHSKVENQYRRVVPDAGNLLAQQAIADVFCVNGDSEWRGLGVIESSGVHLTPDYQRFDAEAHFRPAPQQVCDDPRARCGEVLTGKCKPHQCPLFGNTCNPQTAFGALMVSSEGACAAWYQYRQQESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CK4</accession>
    <name>Q32CK4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanine-nucleotide binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hypB</name>
        <name evidence="3" type="ordered locus">SDY_2924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000337652.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404442.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CK4"/>
    <dbReference type="STRING" id="300267.SDY_2924"/>
    <dbReference type="EnsemblBacteria" id="ABB62951">
        <property type="protein sequence ID" value="ABB62951"/>
        <property type="gene ID" value="SDY_2924"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2924"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3512"/>
    <dbReference type="HOGENOM" id="CLU_056148_1_0_6"/>
    <dbReference type="OMA" id="ECHLDAH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05390">
        <property type="entry name" value="HypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00073">
        <property type="entry name" value="hypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="106"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="290" mass="31507" checksum="D3A6FED2330C90AE" modified="2005-12-06" version="1">MCTTCGCGEGNLYIEGDEHNPHSAFRSAPFAPAAHPKMKITGIKAPEFTPSQTEEGDLHYGHGEAGTHAPGMSQRRMLEVEIDVLDKNNCLAERNRARFAARKQLVLNLVSSPGSGKTTLLTETLMRLKDSVPCAVIEGDQQTVNDAARIRATGTPAIQVNTGKGCHLDAQMIADAAPRLPLDDNAILFIENVGNLVCPASFDLGEKHKVAVLSVTEGEDKPLKYPHMFAAASLMLLNKVDLLPYLNFDVEKCIACAREVNPEIEIILISATSGEGMDQWLNWLETQRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CP1</accession>
    <name>Q32CP1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygaH</name>
        <name evidence="2" type="ordered locus">SDY_2878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000119749.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404405.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CP1"/>
    <dbReference type="STRING" id="300267.SDY_2878"/>
    <dbReference type="EnsemblBacteria" id="ABB62914">
        <property type="protein sequence ID" value="ABB62914"/>
        <property type="gene ID" value="SDY_2878"/>
    </dbReference>
    <dbReference type="GeneID" id="58389157"/>
    <dbReference type="KEGG" id="sdy:SDY_2878"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3460"/>
    <dbReference type="HOGENOM" id="CLU_170834_0_0_6"/>
    <dbReference type="OMA" id="LPDIMQH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="111" mass="11995" checksum="3E392E54DEF3A863" modified="2005-12-06" version="1">MSYEVLLLGLLVGAANYCFRYLPLRLRVGNARPTKRGAVGILLDTIGIASICALLVVSTAPEVMHDTRRFVPTLVGFAVLGASFYKTRSIIIPTLLSALAYGLAWKVMAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CQ0</accession>
    <name>Q32CQ0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="5 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nrdE</name>
        <name evidence="12" type="ordered locus">SDY_2868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="5 10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CQ0"/>
    <dbReference type="STRING" id="300267.SDY_2868"/>
    <dbReference type="EnsemblBacteria" id="ABB62905">
        <property type="protein sequence ID" value="ABB62905"/>
        <property type="gene ID" value="SDY_2868"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2868"/>
    <dbReference type="HOGENOM" id="CLU_000404_4_1_6"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026459">
        <property type="entry name" value="RNR_1b_NrdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013554">
        <property type="entry name" value="RNR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08343">
        <property type="entry name" value="RNR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04170">
        <property type="entry name" value="RNR_1b_NrdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="616" mass="69372" checksum="D55C3FEFF2BB81B4" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CS4</accession>
    <name>Q32CS4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404372.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CS4"/>
    <dbReference type="EnsemblBacteria" id="ABB62881">
        <property type="protein sequence ID" value="ABB62881"/>
        <property type="gene ID" value="SDY_2842"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2842"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3415"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="GHIIAHI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="276" mass="31867" checksum="A27C08E626D7E96E" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQSGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSNHLHVMRQKASSAGHIIAHIPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D12</accession>
    <name>Q32D12_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfhB</name>
        <name evidence="2" type="ordered locus">SDY_2750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D12"/>
    <dbReference type="STRING" id="300267.SDY_2750"/>
    <dbReference type="EnsemblBacteria" id="ABB62793">
        <property type="protein sequence ID" value="ABB62793"/>
        <property type="gene ID" value="SDY_2750"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2750"/>
    <dbReference type="HOGENOM" id="CLU_112917_0_0_6"/>
    <dbReference type="OMA" id="GTFMRYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006435">
        <property type="entry name" value="HAD-SF_hydro_IF_YfhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01545">
        <property type="entry name" value="YfhB_g-proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="190" mass="21912" checksum="F2D8C568EEDB1C30" modified="2005-12-06" version="1">MFGSFLRYLLRRQPLNALLVLPLLPIIAIALLIKGRAARWPMSLLLWGCTFGHSEARLQALQADFVRWFRDNVTAFPLVQERLTTYLLSSDADIWLITGSPQPLVEAVYFDTPWLPRVNLIASQIQRGYGGWVLTMRCLGHEKVAQLERKIGTPLRLYSGYSDSNQDNPLLYFCQHRWRVTPRGELQQLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D36</accession>
    <name>ISCA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Iron-binding protein IscA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Iron-sulfur cluster assembly protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iscA</name>
        <name type="ordered locus">SDY_2724</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 2 iron ions per dimer. The dimer may bind additional iron ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; may form tetramers and higher multimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000028953.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404260.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D36"/>
    <dbReference type="SMR" id="Q32D36"/>
    <dbReference type="STRING" id="300267.SDY_2724"/>
    <dbReference type="EnsemblBacteria" id="ABB62769">
        <property type="protein sequence ID" value="ABB62769"/>
        <property type="gene ID" value="SDY_2724"/>
    </dbReference>
    <dbReference type="GeneID" id="67416912"/>
    <dbReference type="KEGG" id="sdy:SDY_2724"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3286"/>
    <dbReference type="HOGENOM" id="CLU_069054_5_1_6"/>
    <dbReference type="OMA" id="GYQYGMA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01429">
        <property type="entry name" value="Fe_S_insert_IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011302">
        <property type="entry name" value="IscA_proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02011">
        <property type="entry name" value="IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000024377" description="Iron-binding protein IscA">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01429"/>
        </source>
    </evidence>
    <sequence length="107" mass="11556" checksum="CBA945AD547E77DD" modified="2005-12-06" version="1">MSITLSDSAAARVNTFLANRGKGFGLRLGVRTSGCSGMAYVLEFVDEPTPEDIVFEDKGVKVVVDGKSLQFLDGTQLDFVKEGLNEGFKFTNPNVKDECGCGESFHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D69</accession>
    <name>PUR5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="2">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purM</name>
        <name type="ordered locus">SDY_2688</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005017486.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404227.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D69"/>
    <dbReference type="SMR" id="Q32D69"/>
    <dbReference type="STRING" id="300267.SDY_2688"/>
    <dbReference type="EnsemblBacteria" id="ABB62736">
        <property type="protein sequence ID" value="ABB62736"/>
        <property type="gene ID" value="SDY_2688"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2688"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3243"/>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_6"/>
    <dbReference type="OMA" id="EPLFMTD"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000258403" description="Phosphoribosylformylglycinamidine cyclo-ligase">
        <location>
            <begin position="2"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <sequence length="345" mass="36903" checksum="2DBC1274581815D7" modified="2007-01-23" version="3">MTDKTSLSYKDAGVDIDAGNALVGRIKGVVKKTRRPEVMGGLGGFGALCALPQKYREPVLVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASAVISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVLIALGSSGPHSNGYSLVRKILEVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKVDVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVERHEMYRTFNCGVGMIIALPAPEVDKALALLNANGENTWKIGIIKASDSEQRVVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D95</accession>
    <name>Q32D95_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D95"/>
    <dbReference type="STRING" id="300267.SDY_2659"/>
    <dbReference type="ESTHER" id="shifl-YPFH">
        <property type="family name" value="LYsophospholipase_carboxylesterase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62710">
        <property type="protein sequence ID" value="ABB62710"/>
        <property type="gene ID" value="SDY_2659"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2659"/>
    <dbReference type="HOGENOM" id="CLU_190009_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="88" mass="9519" checksum="9CACA84368C08327" modified="2005-12-06" version="1">MKHDHFVVQSSDKPAQQLLLLFHGVGDNPVAMGEIGSWFAPLFPDALVVSVGGAEPSGNPAGRQWFSVQGITEDNRQARVDAIMPDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DK1</accession>
    <name>Q32DK1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yfcS</name>
        <name evidence="10" type="ordered locus">SDY_2535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the periplasmic pilus chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000182872.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404095.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DK1"/>
    <dbReference type="STRING" id="300267.SDY_2535"/>
    <dbReference type="EnsemblBacteria" id="ABB62604">
        <property type="protein sequence ID" value="ABB62604"/>
        <property type="gene ID" value="SDY_2535"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2535"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3051"/>
    <dbReference type="HOGENOM" id="CLU_070768_5_1_6"/>
    <dbReference type="OMA" id="LDNPWQE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036316">
        <property type="entry name" value="Pili_assmbl_chap_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001829">
        <property type="entry name" value="Pili_assmbl_chaperone_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016148">
        <property type="entry name" value="Pili_assmbl_chaperone_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018046">
        <property type="entry name" value="Pili_assmbl_chaperone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016147">
        <property type="entry name" value="Pili_assmbl_chaperone_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02753">
        <property type="entry name" value="PapD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00345">
        <property type="entry name" value="PapD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00969">
        <property type="entry name" value="CHAPERONPILI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="SSF49354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49584">
        <property type="entry name" value="SSF49584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00635">
        <property type="entry name" value="PILI_CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221042" evidence="7">
        <location>
            <begin position="28"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_N" evidence="8">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_C" evidence="9">
        <location>
            <begin position="170"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="249" mass="27737" checksum="AF4B10C28BCCEDE7" modified="2005-12-06" version="1">MTNLFSAKTVATTLAFLITATSLQAQASVTPDRTRLIFNESDKSISVTLRNNDPKMPYLAQSWMEDEQGNKISSPLTVLPPVQRIDSMMNGQVKVQGMSDINKLPADRESVFYFNVREIPPKSNKTNTLQIALQTRIKLFWRPKALENVSMKNPWQHKVTLTRSGQEFTVNNPTPYFVVISNASAQKNGNPAAGFSPMVISPKTSVPLKVKMDSVPVLTYVNDYGARMPLYFKCGGDTCQVDVEQSRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DM5</accession>
    <name>Q32DM5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ubiX</name>
        <name evidence="7" type="ordered locus">SDY_2510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000825700.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404071.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DM5"/>
    <dbReference type="SMR" id="Q32DM5"/>
    <dbReference type="STRING" id="300267.SDY_2510"/>
    <dbReference type="EnsemblBacteria" id="ABB62580">
        <property type="protein sequence ID" value="ABB62580"/>
        <property type="gene ID" value="SDY_2510"/>
    </dbReference>
    <dbReference type="GeneID" id="60903993"/>
    <dbReference type="KEGG" id="sdy:SDY_2510"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3025"/>
    <dbReference type="HOGENOM" id="CLU_074522_0_1_6"/>
    <dbReference type="OMA" id="GATHIQD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="189" mass="20695" checksum="057255DB020BF5B4" modified="2005-12-06" version="1">MKRLIVGISGASGAIYGVRLLQVLRDVTDIETHLVMSQAARQTLSLETDFSLREVQALADVTHDARDIAASISSGSFQTLGMVILPCSIKTLSGIVHSYTDGLLTRAADVVLKERRPLVLCVRETPLHLGHLRLMTQAAEIGAVIMPPVPAFYHRPQSLDDVINQTVNRVLDQFAITLPEDLFARWQGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DR3</accession>
    <name>NUON_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoN</name>
        <name type="ordered locus">SDY_2472</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62542" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62542.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000156727.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404033.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DR3"/>
    <dbReference type="SMR" id="Q32DR3"/>
    <dbReference type="STRING" id="300267.SDY_2472"/>
    <dbReference type="EnsemblBacteria" id="ABB62542">
        <property type="protein sequence ID" value="ABB62542"/>
        <property type="gene ID" value="SDY_2472"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2472"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2983"/>
    <dbReference type="HOGENOM" id="CLU_007100_1_5_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000249450" description="NADH-quinone oxidoreductase subunit N">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="485" mass="52100" checksum="870056559A85B5DC" modified="2006-09-19" version="2">MTITPQNLIALLPLLIVGLTVVVVMLSIAWRRNHFLNATLSVIGLNAALVSLWFVGQVGAMDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNKDEFYLLVLIAALGGILLANANHLASLFLGIELISLPLFGLVGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQSGDLSFVALGKNLGDGMLNEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVSTFLATASKIVIFGVVMRLFLYAPVGDSEAIRVVLAIIAFASIIFGNLMALSQTNIKRLLGYSSISHLGYLLVALIALQTGEMSMEAVGVYLAGYLFSSLGAFGVVSLMSSPYRGPDADSLFSYRGLFWHRPILAAVMTVMMLSLAGIPMTLGFIGKFYVLAVGVQAHLWWLVGAVVVGSAIGLYYYLRVAVSLYLHAPEQPGRDAPSNWQYSAGGIVVLISALLVLVLGVWPQPLISIVRLAMPLM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DT1</accession>
    <name>ARNT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase</fullName>
            <ecNumber evidence="1">2.4.2.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-amino-4-deoxy-L-arabinose lipid A transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl phosphate-alpha-L-Ara4N transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">arnT</name>
        <name type="ordered locus">SDY_2453</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IVA = lipid IIA + di-trans,octa-cis-undecaprenyl phosphate.</text>
            <dbReference type="EC" id="2.4.2.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipopolysaccharide metabolism; 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 83 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.43" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000844007.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404015.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DT1"/>
    <dbReference type="SMR" id="Q32DT1"/>
    <dbReference type="STRING" id="300267.SDY_2453"/>
    <dbReference type="CAZy" id="GT83">
        <property type="family name" value="Glycosyltransferase Family 83"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62524">
        <property type="protein sequence ID" value="ABB62524"/>
        <property type="gene ID" value="SDY_2453"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2453"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2959"/>
    <dbReference type="HOGENOM" id="CLU_019200_2_1_6"/>
    <dbReference type="OMA" id="TFWPGAP"/>
    <dbReference type="UniPathway" id="UPA00037"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103015">
        <property type="term" value="F:4-amino-4-deoxy-L-arabinose transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01165">
        <property type="entry name" value="ArnT_transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022839">
        <property type="entry name" value="ArnT_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000380038" description="Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase">
        <location>
            <begin position="1"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01165"/>
        </source>
    </evidence>
    <sequence length="550" mass="62608" checksum="90A0905BF069AF5C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DV6</accession>
    <name>Q32DV6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DV6"/>
    <dbReference type="STRING" id="300267.SDY_2426"/>
    <dbReference type="EnsemblBacteria" id="ABB62499">
        <property type="protein sequence ID" value="ABB62499"/>
        <property type="gene ID" value="SDY_2426"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2426"/>
    <dbReference type="HOGENOM" id="CLU_1271555_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013425">
        <property type="entry name" value="Autotrns_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12951">
        <property type="entry name" value="PATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02601">
        <property type="entry name" value="autotrns_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="217" mass="22026" checksum="A4B0BE4F01D4885A" modified="2005-12-06" version="1">MLVDENNSAAGYGDGPSSAAGGFMYLGLSEVTFDIADGKTLVIGNTENDGAVDSIAGTGLITKTGSGDLVLNADNNDFTGEMQIENGEVTLGRSNSLMNVGDTHCQDDPQDCYGLTIGSIDKYQNQAELNVGSTQQTFVHSLTGFQNGTLNIDAGGNVTVNQGSFAGTIEGAGQLTIAQNGSYVLAGAQSMALTGDIVVDDGAVLSLEGDAADLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DX5</accession>
    <name>Q32DX5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arginine 3rd transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">artQ</name>
        <name evidence="9" type="ordered locus">SDY_2406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001001693.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403971.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DX5"/>
    <dbReference type="STRING" id="300267.SDY_2406"/>
    <dbReference type="EnsemblBacteria" id="ABB62480">
        <property type="protein sequence ID" value="ABB62480"/>
        <property type="gene ID" value="SDY_2406"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2406"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2903"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_4_6"/>
    <dbReference type="OMA" id="SVGPYRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="11"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="238" mass="26245" checksum="88362BBCC3B7D23C" modified="2005-12-06" version="1">MNEFFPLASAAGMTVGLAVCALIVGLALAMFFAVWESAKWRPVAWAGSALVTILRGLPEILVVLFIYFGSSQLLLTLSDGFTINLGFVQIPVQMDIENFDVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVLLKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIVVAAIYLVITLLSQYILKRIDLRATRFERRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E06</accession>
    <name>Q32E06_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding component of cytochrome-related transport, Zn sensitive</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cydD</name>
        <name evidence="10" type="ordered locus">SDY_2374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="AlphaFoldDB" id="Q32E06"/>
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    <dbReference type="EnsemblBacteria" id="ABB62449">
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    <dbReference type="OMA" id="FPLNWAA"/>
    <dbReference type="Proteomes" id="UP000002716">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="29"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="350"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="383"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="588" mass="65086" checksum="8223E66C5F92D252" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E50</accession>
    <name>Q32E50_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Outer membrane protein 1a (IabF)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ompF</name>
        <name evidence="9" type="ordered locus">SDY_2328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cell outer membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the Gram-negative porin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E50"/>
    <dbReference type="STRING" id="300267.SDY_2328"/>
    <dbReference type="EnsemblBacteria" id="ABB62405">
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        <property type="gene ID" value="SDY_2328"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2328"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2810"/>
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    <dbReference type="OMA" id="DAIGWTD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001897">
        <property type="entry name" value="Porin_gammaproteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013793">
        <property type="entry name" value="Porin_Gram-ve_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00267">
        <property type="entry name" value="Porin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00183">
        <property type="entry name" value="ECOLIPORIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00182">
        <property type="entry name" value="ECOLNEIPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00576">
        <property type="entry name" value="GRAM_NEG_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220800" evidence="8">
        <location>
            <begin position="23"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="362" mass="39347" checksum="1E689D1C98FFD217" modified="2005-12-06" version="1">MMKRNILAVIVPALLVAGTANAAEIYNKDGNKVDLYGKAVGLHYFSKGNGENSYGGNGDMTYARLGFKGETQINSDLTGYGQWEYNFQGNNSEGADAQTGNKTRLAFAGLKYADVGSFDYGRNYGVVYDALGYTDMLPEFGGDTAYSDDFFVGRVGGVATYRNSNFFGLVDGLNFAVQYLGKNERDSARRSNGDGVGGSISYEYEGFGIVGAYGAADRTNLQEAQLLGNGKKAEQWATGLKYDANNIYLAANYGETRNATPITNKFTNISGFANKTQDVLLVAQYQFDFGLRPSIAYTKSKAKDVEGIGDVDLVNYFEVGATYYFNKNMSTYVDYIINQIDSDNKLGVGSDDTVAVGIVYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EB7</accession>
    <name>Q32EB7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative plasmid stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403829.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EB7"/>
    <dbReference type="EnsemblBacteria" id="ABB62338">
        <property type="protein sequence ID" value="ABB62338"/>
        <property type="gene ID" value="SDY_2258"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2258"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2727"/>
    <dbReference type="HOGENOM" id="CLU_147162_3_3_6"/>
    <dbReference type="OMA" id="SHVIYYI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="92" mass="10771" checksum="4F3213DAFE7BE27F" modified="2005-12-06" version="1">MPKANEDLEGIWYYSYHHFGEPQADRYVEHLSDVLQILSNNNVGTPRPELGEGIFVLPFERHVIYFLQSPGEIIVIRILNQNQDATRHLHWS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EK8</accession>
    <name>YOHO_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0387 membrane protein YohO</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yohO</name>
        <name type="ordered locus">SDY_2161</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0387 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001216963.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EK8"/>
    <dbReference type="EnsemblBacteria" id="ABB62247">
        <property type="protein sequence ID" value="ABB62247"/>
        <property type="gene ID" value="SDY_2161"/>
    </dbReference>
    <dbReference type="GeneID" id="66673977"/>
    <dbReference type="KEGG" id="sdy:SDY_2161"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2613"/>
    <dbReference type="HOGENOM" id="CLU_220259_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01362">
        <property type="entry name" value="UPF0387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020870">
        <property type="entry name" value="UPF0387_membrane"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000252202" description="UPF0387 membrane protein YohO">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01362"/>
        </source>
    </evidence>
    <sequence length="35" mass="3643" checksum="90EE2B64F4CCB96A" modified="2005-12-06" version="1">MRIAKIGVIALFLFMALGGIGGVMLAGYTFILRAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EU9</accession>
    <name>RL32_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmF</name>
        <name type="ordered locus">SDY_2061</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000290727.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403647.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EU9"/>
    <dbReference type="SMR" id="Q32EU9"/>
    <dbReference type="STRING" id="300267.SDY_2061"/>
    <dbReference type="EnsemblBacteria" id="ABB62156">
        <property type="protein sequence ID" value="ABB62156"/>
        <property type="gene ID" value="SDY_2061"/>
    </dbReference>
    <dbReference type="GeneID" id="67414282"/>
    <dbReference type="KEGG" id="sdy:SDY_2061"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2476"/>
    <dbReference type="HOGENOM" id="CLU_129084_2_1_6"/>
    <dbReference type="OMA" id="GMHRAHD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000225763" description="50S ribosomal protein L32">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="57" mass="6446" checksum="FA07955DAA8E4E94" modified="2005-12-06" version="1">MAVQQNKPTRSKRGMRRSHDALTAVTSLSVDKTSGEKHLRHHITADGYYRGRKVIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F41</accession>
    <name>Q32F41_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PTS system mannose-specific EIIAB component</fullName>
            <ecNumber evidence="4">2.7.1.191</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">EIIAB-Man</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">EIII-Man</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">manX</name>
        <name evidence="20" type="ordered locus">SDY_1963</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannose 6-phosphate(in) + L-histidyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:49232"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.1.191"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.191" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000150527.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403555.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F41"/>
    <dbReference type="STRING" id="300267.SDY_1963"/>
    <dbReference type="EnsemblBacteria" id="ABB62064">
        <property type="protein sequence ID" value="ABB62064"/>
        <property type="gene ID" value="SDY_1963"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1963"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2370"/>
    <dbReference type="HOGENOM" id="CLU_074797_0_0_6"/>
    <dbReference type="OMA" id="EMIFGKQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00006">
        <property type="entry name" value="PTS_IIA_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00001">
        <property type="entry name" value="PTS_IIB_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.35.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013789">
        <property type="entry name" value="PTS_EIIA_man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033887">
        <property type="entry name" value="PTS_IIA_man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004720">
        <property type="entry name" value="PTS_IIB_sorbose-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036667">
        <property type="entry name" value="PTS_IIB_sorbose-sp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018455">
        <property type="entry name" value="PTS_IIB_sorbose-sp_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03830">
        <property type="entry name" value="PTSIIB_sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52728">
        <property type="entry name" value="SSF52728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00824">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00854">
        <property type="entry name" value="pts-sorbose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51101">
        <property type="entry name" value="PTS_EIIB_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="18">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-4" evidence="19">
        <location>
            <begin position="160"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ABB62064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="323" mass="35020" checksum="39D24EF1B7E1A164" modified="2005-12-06" version="1">MTIAIVIGTHGWAAEQLLKTAEMLLGEQENVGWIDFVPGENAETLIEKYNAQLAKLDTTKGVLFLVDTWGGSPFNAASRIVVDKEHYEVIAGINIPMLVETLMARDDDPSFDELVALAVETGREGVKALKAKPVEKAAPAPAAAAPKAAPTPAKPMGPNDYMVIGLARIDDRLIHGQVATRWTKETNVSRIIVVSDEVAADTVRKTLLTQVAPPGVTAHVVDVAKMIRVYNNPKYAGERVMLLFTNPTDVERLVEGGVKITSVNVGGMAFRQGKTQVNNAVSVDEKDIEAFNKLNARGIELEVRKVSTDPKLKMMDLISKIDT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F89</accession>
    <name>SUFE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cysteine desulfuration protein SufE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sufE</name>
        <name type="ordered locus">SDY_1910</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Interacts with SufS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SufE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000279738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403507.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F89"/>
    <dbReference type="SMR" id="Q32F89"/>
    <dbReference type="STRING" id="300267.SDY_1910"/>
    <dbReference type="EnsemblBacteria" id="ABB62016">
        <property type="protein sequence ID" value="ABB62016"/>
        <property type="gene ID" value="SDY_1910"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1910"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2299"/>
    <dbReference type="HOGENOM" id="CLU_124502_1_1_6"/>
    <dbReference type="OMA" id="DWMQRYE"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01832">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023939">
        <property type="entry name" value="Cysteine_desulfuration_SufE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43597">
        <property type="entry name" value="PTHR43597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000070447" description="Cysteine desulfuration protein SufE">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01832"/>
        </source>
    </evidence>
    <sequence length="138" mass="15758" checksum="92F58475B1B988B8" modified="2005-12-06" version="1">MAVLPDKEKLLRNFLRCANWEEKYLYIIELGQRLPELRDEGRSPQNSIQGCQSQVWIVMRQNAQGIIELQGDSDAAIVKGLIAVVFILYDQMMPQDIVNFDVRPWFEKMALTQHLTPSRSQGLEAMIRAIRAKAAALS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FA7</accession>
    <name>MDTK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multidrug resistance protein MdtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Multidrug-efflux transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdtK</name>
        <name type="ordered locus">SDY_1890</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001174959.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403489.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FA7"/>
    <dbReference type="SMR" id="Q32FA7"/>
    <dbReference type="STRING" id="300267.SDY_1890"/>
    <dbReference type="EnsemblBacteria" id="ABB61998">
        <property type="protein sequence ID" value="ABB61998"/>
        <property type="gene ID" value="SDY_1890"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1890"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2275"/>
    <dbReference type="HOGENOM" id="CLU_012893_6_0_6"/>
    <dbReference type="OMA" id="TGNQKVG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006855">
        <property type="term" value="P:xenobiotic transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00400">
        <property type="entry name" value="MdtK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022913">
        <property type="entry name" value="Multidrug-R_MdtK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0915">Sodium</keyword>
    <keyword id="KW-0739">Sodium transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000279853" description="Multidrug resistance protein MdtK">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00400"/>
        </source>
    </evidence>
    <sequence length="457" mass="49449" checksum="3C3D965F2AD39E5C" modified="2005-12-06" version="1">MQKYISEARLLLALAIPVILAQIAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRERIAHQVRQGFWLAGFVSVLIMLVLWNAGYIIRSMENIDPALADKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNYIFIYGHFGMPELSGVGCGVATAAVYWAMFLAMVSYIKRARSMRDIRNEKGTAKPDPAVMKRLIQLGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPMSLAAAVTIRVGYRLGQGSTLDAQTAARTGLMVGVCMATLTAIFTVSLREQIALLYNDNPEVVTLAAHLMLLAAVYQISDSIQVIGSGILRGYKDTRSIFYITFTAYWVLGLPSGYILALTDLVVEPMGPAGFWIGFIIGLTSAAIMMMLRMRFLQRLPSAIILQRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FC1</accession>
    <name>Q32FC1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FC1"/>
    <dbReference type="EnsemblBacteria" id="ABB61984">
        <property type="protein sequence ID" value="ABB61984"/>
        <property type="gene ID" value="SDY_1875"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1875"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7433" checksum="B1793D99540D2AB5" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITPYFYGTADASAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FK5</accession>
    <name>Q32FK5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ARAC-type regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022426.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403391.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FK5"/>
    <dbReference type="STRING" id="300267.SDY_1786"/>
    <dbReference type="EnsemblBacteria" id="ABB61900">
        <property type="protein sequence ID" value="ABB61900"/>
        <property type="gene ID" value="SDY_1786"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1786"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2154"/>
    <dbReference type="HOGENOM" id="CLU_1583972_0_0_6"/>
    <dbReference type="OMA" id="APKWESG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="180" mass="20207" checksum="CDAAE257F85D2386" modified="2005-12-06" version="1">MYQRCFDNASETLFVAGKTPRLSRFAFSDAPKWESGHHVHDNETELIYVKKGVARFTIDSSLYVAHADDIVVIERGRLHAVASDVNDPATTCTCALYGFQFQGAEENQLLQPHSCPVIAAGQGKEVIKTLFNELSVILPQSKNSQTSSLWDAFAYTLAILYYENFKNAYRSEQGYIKKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FN3</accession>
    <name>Q32FN3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FN3"/>
    <dbReference type="EnsemblBacteria" id="ABB61872">
        <property type="protein sequence ID" value="ABB61872"/>
        <property type="gene ID" value="SDY_1755"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1755"/>
    <dbReference type="HOGENOM" id="CLU_2805630_0_0_6"/>
    <dbReference type="OMA" id="NTDRAMF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7369" checksum="DFC73C1D58156894" modified="2005-12-06" version="1">MADKVYLKYTPSDYSFNLGKNASGIVFNQTAPPEEGAEEKTINSSRGRQHTDVYPAQAGNTDTAMFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FP1</accession>
    <name>Q32FP1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurite resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tehB</name>
        <name evidence="2" type="ordered locus">SDY_1747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000586725.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403355.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FP1"/>
    <dbReference type="STRING" id="300267.SDY_1747"/>
    <dbReference type="EnsemblBacteria" id="ABB61864">
        <property type="protein sequence ID" value="ABB61864"/>
        <property type="gene ID" value="SDY_1747"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1747"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2106"/>
    <dbReference type="HOGENOM" id="CLU_056435_2_0_6"/>
    <dbReference type="OMA" id="VFMFLNR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046690">
        <property type="term" value="P:response to tellurium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015985">
        <property type="entry name" value="TehB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004537">
        <property type="entry name" value="Tellurite-R_MeTrfase_TehB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03848">
        <property type="entry name" value="TehB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00477">
        <property type="entry name" value="tehB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TehB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="197" mass="22462" checksum="44BC867E4818D3E5" modified="2005-12-06" version="1">MIIRDENYFTDKYELTRTHSEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGYDVDAWDKNAMSIANVERIKSIENLDNLHTRVVDLNNLTFDGQYDFILSTVVLMFLEAKTIPGLITNMQRCTKPGGYNLIVAAMDTADYPCTVGFPFAFKEGELRRYYEGWERVKYNEDVGELHRTDANGNRIKLRFATMLARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FQ4</accession>
    <name>Q32FQ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000220392.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403342.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FQ4"/>
    <dbReference type="STRING" id="300267.SDY_1733"/>
    <dbReference type="EnsemblBacteria" id="ABB61851">
        <property type="protein sequence ID" value="ABB61851"/>
        <property type="gene ID" value="SDY_1733"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1733"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2091"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_6"/>
    <dbReference type="OMA" id="PFSIRPE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="337" mass="37017" checksum="B2B93C8850381463" modified="2005-12-06" version="1">MTYAVEFDNVSRLYGDVRAVDGVSIAIKDGEFFSMLGPSGSGKTTCLRLIAGFEQLSGGAISIFGKPASNLPPWERDVNTVFQDYALFPHMSILDNVAYGLMVKGVNKKQRHAMAQEALEKVALGFAQQRKPSQLSGGQRQRVAIARALVNEPRVLLLDEPLGALDLKLREQMQLELKKLQQSLGITFIFVTHDQGEALSMSDRVVVFNNGRIELVDSPRDLYMRPRTPFVAGFVGTSNVFDGLMAEKLCGMTGSFALRPEHIRLNTPGELQANGTIQAVQYQGAATRFELKLNGGEKLLVSQANMTGEELPATLTPGQQVMVSWSRDVMVPLVEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G17</accession>
    <name>Q32G17_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GHL10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000350393.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403229.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G17"/>
    <dbReference type="STRING" id="300267.SDY_1613"/>
    <dbReference type="EnsemblBacteria" id="ABB61738">
        <property type="protein sequence ID" value="ABB61738"/>
        <property type="gene ID" value="SDY_1613"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1613"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1941"/>
    <dbReference type="HOGENOM" id="CLU_019247_0_1_6"/>
    <dbReference type="OMA" id="YGPWSEY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220706" description="GHL10 domain-containing protein" evidence="3">
        <location>
            <begin position="33"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="GHL10" evidence="4">
        <location>
            <begin position="55"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="439" mass="49546" checksum="3E6B67714DD6CDF6" modified="2005-12-06" version="1">MDICSRNKKLTIRRPAILVALALLLCSCKSTPPESMVTPPAGSKPPATTQQSSQPMRGIWLATVSRLDWPPVSSVNISNPTSRARVQQQAMIDKLDHLQRLGINTVFFQVKPDGTALWPSKILPWSDLMTGKIGENPGYDPLQFMLDEAHKRGMKVHAWFNPYRVSVNTKPGTIRELNSTLSQQPASVYVQHRDWIRTSGDRFVLDPGIPEVQDWITSIVAEVVSRYPVDGVQFDDYFYTESPGSRLNDNETYRKYGGAFASKADWRRNNTQQLIAKVSHTIKSIKPGVEFGVSPAGVWRNRSHDPLGSDTRGAAAYDESYADTRRWVEQGLLDYIAPQIYWPFSRSAARYDVLAKWWADVVKPTKTRLYIGIAFYKVGEPSKIEPDWMINGGVPELKKQLDLNDAVPEISGTILFREDYLNKPQTQQAVSYLQSRWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GD0</accession>
    <name>Q32GD0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative aldehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001186334.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403116.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GD0"/>
    <dbReference type="STRING" id="300267.SDY_1486"/>
    <dbReference type="EnsemblBacteria" id="ABB61625">
        <property type="protein sequence ID" value="ABB61625"/>
        <property type="gene ID" value="SDY_1486"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1486"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1774"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_6"/>
    <dbReference type="OMA" id="HCRFVNM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="17"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="283" mass="30809" checksum="B08070B76268505E" modified="2005-12-06" version="1">MQQKMIQFSGDVSLPAIGQGTWYMGEDASKCKTEVAALRAGIELGLTLIDIAEMYADGGAEKVVGEALTGLRDSVFLVSKVYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAFEETVAAMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQCATNQVLYHLGSRGIEYDLLPWCQQQMLVMAYSLLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAIPKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GH6</accession>
    <name>Q32GH6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Antitermination protein Q homolog of cryptic prophage</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000762869.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403070.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GH6"/>
    <dbReference type="STRING" id="300267.SDY_1436"/>
    <dbReference type="EnsemblBacteria" id="ABB61579">
        <property type="protein sequence ID" value="ABB61579"/>
        <property type="gene ID" value="SDY_1436"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1436"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1712"/>
    <dbReference type="HOGENOM" id="CLU_095309_0_0_6"/>
    <dbReference type="OMA" id="YSPKSPC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04158">
        <property type="entry name" value="Antitermination_lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038500">
        <property type="entry name" value="Antitermination_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003222">
        <property type="entry name" value="Antitermntn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03589">
        <property type="entry name" value="Antiterm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="273" mass="30675" checksum="57B1DAE9F943881D" modified="2005-12-06" version="1">MKLEDLPKYYSPKSPCLTDASASTSKDALSITDVMAAQGMTQNRAEMGFSAFLGKMGISMNDRARETELLADYALSRCDRVAALRKLPAEIKPLVMRIMASYAFEDYARSAASKKQCPCCYGEKFIESVVFANKVQYPDGKPPVWAKCTKGVYPSYWEEWKKVREVVKVACPECGGKGEVSTACKDCRGRGVAIHREESVKRGMSVIRDCQRCGGRGYERLPSTEAFNAICEVTNQITRASWEKTVKKFYDALVTRFDIEEAWAERQLKKVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GN4</accession>
    <name>Q32GN4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISSfl2 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005023257.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403012.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GN4"/>
    <dbReference type="STRING" id="300267.SDY_1376"/>
    <dbReference type="EnsemblBacteria" id="ABB61521">
        <property type="protein sequence ID" value="ABB61521"/>
        <property type="gene ID" value="SDY_1376"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1376"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1633"/>
    <dbReference type="HOGENOM" id="CLU_036902_2_3_6"/>
    <dbReference type="OMA" id="YYTRKVE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="14"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="398" mass="43111" checksum="6007CA218D00D5FB" modified="2005-12-06" version="1">MTESSDYESVQVFIGVDVGKDTHHAVAINRSGKRLFDKALPNDENKLRSLISDLKQHGQILLVVDQPATIGALPVAVARSEGVLVGHLPGLAMRRIADLHAGEAKTDARDAAIIAEAARTLPHALRTLKLADEQIAELSMLCGFDDDLAAQTTQASNRIRGLLTQIHPALERVLGPRLEHPAVLDLLQRYPSPEKLASLGEKKLAAQLCKLAPRLGKRLAADIAQALAEQTVVVPGTNAAAVVLPRLALQLITLRKQRDEVALEVEQRVLAHPLYPVLTSMPGVGVRTAARLLTEVACRAFASAAHLAAYAGLAPVTRRSGSSIRGEHPSRRGNKALKRALFLSAFAALRDPLSRAYYTRKMSQGKRHNQALIALARRRCDVLFAMMRDGTFYTPQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GR4</accession>
    <name>Q32GR4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">topA</name>
        <name evidence="13" type="ordered locus">SDY_1344</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378684.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402982.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GR4"/>
    <dbReference type="STRING" id="300267.SDY_1344"/>
    <dbReference type="EnsemblBacteria" id="ABB61491">
        <property type="protein sequence ID" value="ABB61491"/>
        <property type="gene ID" value="SDY_1344"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1344"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1593"/>
    <dbReference type="HOGENOM" id="CLU_002929_4_3_6"/>
    <dbReference type="OMA" id="PECKYTR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013263">
        <property type="entry name" value="TopoI_Znr_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08272">
        <property type="entry name" value="Topo_Zn_Ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="192"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB61491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="865" mass="97385" checksum="29B39EDEF649A096" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GR5</accession>
    <name>Q32GR5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yciN</name>
        <name evidence="1" type="ordered locus">SDY_1343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001031530.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402981.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GR5"/>
    <dbReference type="SMR" id="Q32GR5"/>
    <dbReference type="STRING" id="300267.SDY_1343"/>
    <dbReference type="EnsemblBacteria" id="ABB61490">
        <property type="protein sequence ID" value="ABB61490"/>
        <property type="gene ID" value="SDY_1343"/>
    </dbReference>
    <dbReference type="GeneID" id="67417407"/>
    <dbReference type="KEGG" id="sdy:SDY_1343"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1592"/>
    <dbReference type="HOGENOM" id="CLU_164128_0_0_6"/>
    <dbReference type="OMA" id="DYLHGMV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019633">
        <property type="entry name" value="DUF2498"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038191">
        <property type="entry name" value="YciN_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10692">
        <property type="entry name" value="DUF2498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9386" checksum="558ACD3DD8DFFCA4" modified="2005-12-06" version="1">MNKETQPIDRETLLKEANKIIREHEDTLAGIEATGVTQRNGVLVFTGDYFLDEQGLPTAKSTAVFNMFKHLAHVLSEKYHLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GS5</accession>
    <name>Q32GS5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">trp operon leader peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trpL</name>
        <name evidence="5" type="ordered locus">SDY_1333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in control of the biosynthesis of tryptophan.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001700591.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61480">
        <property type="protein sequence ID" value="ABB61480"/>
        <property type="gene ID" value="SDY_1333"/>
    </dbReference>
    <dbReference type="GeneID" id="67417416"/>
    <dbReference type="KEGG" id="sdy:SDY_1333"/>
    <dbReference type="HOGENOM" id="CLU_222400_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013205">
        <property type="entry name" value="Leader_Trp_op"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08255">
        <property type="entry name" value="Leader_Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0428">Leader peptide</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="14" mass="1723" checksum="5B79306E3E804A37" modified="2005-12-06" version="1">MKAIFVLKGWWRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GV3</accession>
    <name>Q32GV3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OppF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oppF</name>
        <name evidence="6" type="ordered locus">SDY_1305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000994907.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402943.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GV3"/>
    <dbReference type="STRING" id="300267.SDY_1305"/>
    <dbReference type="EnsemblBacteria" id="ABB61452">
        <property type="protein sequence ID" value="ABB61452"/>
        <property type="gene ID" value="SDY_1305"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1305"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1551"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_6"/>
    <dbReference type="OMA" id="EPLRTYY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="334" mass="37167" checksum="06DBCC0C206A54E8" modified="2005-12-06" version="1">MNAVTEGRKVLLEIADLKVHFEIKDGKQWFWQPPKTLKAVDGVTLRLYEGETLGVVGESGCGKSTFARAIIGLVKATDGHVAWLGKELLGMKPDEWRAVRSDIQMIFQDPLASLNPRMTIGEIIAEPLRTYHPKMSRQEVRERVKAMMLKVGLLPNLINRYPHEFSGGQCQRIGIARALILEPKLIICDEPVSALDVSIQAQVVNLLQQLQREMGLSLIFIAHDLAVVKHISDRVLVMYLGHAVELGTYDEVYHNPLHPYTRALMSAVPIPDPDLEKNNTIQLLEGELPSPINPPSGCVFRTRCPIAGPECAKTRPVLEGSFRHAVSCLKVDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GV6</accession>
    <name>Q32GV6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transport permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">oppB</name>
        <name evidence="9" type="ordered locus">SDY_1302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000911088.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402940.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GV6"/>
    <dbReference type="STRING" id="300267.SDY_1302"/>
    <dbReference type="EnsemblBacteria" id="ABB61449">
        <property type="protein sequence ID" value="ABB61449"/>
        <property type="gene ID" value="SDY_1302"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1302"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1548"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_6"/>
    <dbReference type="OMA" id="FLMVNVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="94"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="306" mass="33425" checksum="42152DB115C48614" modified="2005-12-06" version="1">MLKFILRRCLEAIPTLFILITISFFMIRLAPGSPFTGERTLPPEVMANIEAKYHLNDPIMTQYFSYLKQLAHGDFGPSFKYKDYSVNDLVASSFPVSAKLGAAAFFLAVILGVSAGVIAALKQNTKWDYTVMGLAMTGVVIPSFVVAPLLVMIFAIILHWLPGGGWNGGALKFMILPMVALSLAYIASIARITRGSMIEVLHSNFIRTARAKGLPMRRIILRHALKPALLPVLSYMGPAFVGIITGSMVIETIYGLPGIGQLFVNGALNRDYSLVLSLTILVGALTILFNAIVDVLYAVIDPKIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HA9</accession>
    <name>Q32HA9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH rpiR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HA9"/>
    <dbReference type="STRING" id="300267.SDY_1139"/>
    <dbReference type="EnsemblBacteria" id="ABB61296">
        <property type="protein sequence ID" value="ABB61296"/>
        <property type="gene ID" value="SDY_1139"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1139"/>
    <dbReference type="HOGENOM" id="CLU_122864_0_0_6"/>
    <dbReference type="OMA" id="HECHEHA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="14899" checksum="5203036F2103547E" modified="2005-12-06" version="1">MNMLEKIQSQLEHLSKSERKVAEVILASPDNAIHSSIAALALEANVSEPTVNRFCRSMDTRGFPDFKLHLAQSLANGTPYVNRNVNEDNSVESYTGKIFESAMATLAHVRHSLDKSAINRAVDLLTQAKKSPFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HE1</accession>
    <name>Q32HE1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 2-component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">uvrY</name>
        <name evidence="5" type="ordered locus">SDY_1104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000611328.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402755.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HE1"/>
    <dbReference type="SMR" id="Q32HE1"/>
    <dbReference type="STRING" id="300267.SDY_1104"/>
    <dbReference type="EnsemblBacteria" id="ABB61264">
        <property type="protein sequence ID" value="ABB61264"/>
        <property type="gene ID" value="SDY_1104"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1104"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1300"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_6"/>
    <dbReference type="OMA" id="HQGNANF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="218" mass="23863" checksum="7F2B48720FA2DDB7" modified="2005-12-06" version="1">MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HJ4</accession>
    <name>Q32HJ4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Very short patch repair endonuclease</fullName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vsr</name>
        <name evidence="6" type="ordered locus">SDY_1046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May nick specific sequences that contain T:G mispairs resulting from m5C-deamination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vsr family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000785996.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402702.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HJ4"/>
    <dbReference type="STRING" id="300267.SDY_1046"/>
    <dbReference type="REBASE" id="11594">
        <property type="entry name" value="V.SdySDcmP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61211">
        <property type="protein sequence ID" value="ABB61211"/>
        <property type="gene ID" value="SDY_1046"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1046"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1222"/>
    <dbReference type="HOGENOM" id="CLU_111913_1_1_6"/>
    <dbReference type="OMA" id="HDCYLFK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00221">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004603">
        <property type="entry name" value="DNA_mismatch_endonuc_vsr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03852">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018267">
        <property type="entry name" value="VSR_endonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00632">
        <property type="entry name" value="vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="156" mass="17959" checksum="2578E8672E22C1AA" modified="2005-12-06" version="1">MADVHDKATRSKNMRAIATRDTAIEKRLASLLTGQGLAFRVQDASLPGRPDFVVDEYLCVIFTHGCFWHHHHCYLFKVPATRTEFWLEKIGKNVERDRRDISRLQELGWRVLIVWECALRGREKLTDEALSERLEEWICGEGASAQIDTQGIHLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HM8</accession>
    <name>Q32HM8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yeeT</name>
        <name evidence="2" type="ordered locus">SDY_1012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YeeT/YkfH/YpjJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000692331.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402668.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HM8"/>
    <dbReference type="EnsemblBacteria" id="ABB61177">
        <property type="protein sequence ID" value="ABB61177"/>
        <property type="gene ID" value="SDY_1012"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1012"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1180"/>
    <dbReference type="HOGENOM" id="CLU_201031_0_0_6"/>
    <dbReference type="OMA" id="MKIIPRG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009329">
        <property type="entry name" value="DUF987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06174">
        <property type="entry name" value="DUF987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="73" mass="8467" checksum="C81EBC126E2BDCB9" modified="2005-12-06" version="1">MKIITRGEAMRIHQQYPASRLFPFCTGKYRWHGSTETYTGREVQDIPGVLAVFAERRKDSFGPYVRLMSVTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HN4</accession>
    <name>Q32HN4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4942 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020348.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402662.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HN4"/>
    <dbReference type="STRING" id="300267.SDY_1006"/>
    <dbReference type="EnsemblBacteria" id="ABB61171">
        <property type="protein sequence ID" value="ABB61171"/>
        <property type="gene ID" value="SDY_1006"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1006"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1174"/>
    <dbReference type="HOGENOM" id="CLU_063205_0_1_6"/>
    <dbReference type="OMA" id="EMFNIRY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031339">
        <property type="entry name" value="DUF4942"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13708">
        <property type="entry name" value="DUF4942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4942" evidence="1">
        <location>
            <begin position="88"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="280" mass="32583" checksum="0A43FD32C2C9B342" modified="2005-12-06" version="1">MSDITISRLEVVNGHTDIICSTSVSHILAVRKTTLLQIDTLIRQLTEISAMTESIGGKTALDWAMKQDFRCGCWLMDKPDTAMKAITRNLDREIWRDLMQCSGMLSLMDAQARDTWYRSLEYDNFPEISEENILSTFEQLHQNKDEVFERGVINLFRGLSWNYKTNCPCKFGNKIIVNNLVRWDRWGLHLITGQQADRLADLERMLHLFSGKPIPDNRENITIHLDDHIRSLQGKECYEDEMFIIKYFKKGSAHITFRKPELVDRLNDIIAKHYPDMLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I25</accession>
    <name>Q32I25_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Large extracellular alpha-helical protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yfaSR</name>
        <name evidence="4" type="ordered locus">SDY_0852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000536576.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402521.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I25"/>
    <dbReference type="STRING" id="300267.SDY_0852"/>
    <dbReference type="EnsemblBacteria" id="ABB61030">
        <property type="protein sequence ID" value="ABB61030"/>
        <property type="gene ID" value="SDY_0852"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0852"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.986"/>
    <dbReference type="HOGENOM" id="CLU_004561_0_0_6"/>
    <dbReference type="OMA" id="YAYYADW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A2M_N_2" evidence="2">
        <location>
            <begin position="630"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="A2M" evidence="3">
        <location>
            <begin position="841"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1504" mass="166597" checksum="E806EA97151DF73C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-06-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I86</accession>
    <name>Q32I86_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0789</name>
        <name evidence="4" type="ordered locus">SDY_1040</name>
        <name evidence="5" type="ordered locus">SDY_1667</name>
        <name evidence="6" type="ordered locus">SDY_1727</name>
        <name evidence="7" type="ordered locus">SDY_1759</name>
        <name evidence="8" type="ordered locus">SDY_1889</name>
        <name evidence="9" type="ordered locus">SDY_2093</name>
        <name evidence="10" type="ordered locus">SDY_2333</name>
        <name evidence="11" type="ordered locus">SDY_2555</name>
        <name evidence="12" type="ordered locus">SDY_2983</name>
        <name evidence="13" type="ordered locus">SDY_3091</name>
        <name evidence="14" type="ordered locus">SDY_3162</name>
        <name evidence="15" type="ordered locus">SDY_3233</name>
        <name evidence="16" type="ordered locus">SDY_3261</name>
        <name evidence="17" type="ordered locus">SDY_3704</name>
        <name evidence="18" type="ordered locus">SDY_3738</name>
        <name evidence="19" type="ordered locus">SDY_4152</name>
        <name evidence="20" type="ordered locus">SDY_4209</name>
        <name evidence="21" type="ordered locus">SDY_4487</name>
        <name evidence="22" type="ordered locus">SDY_4576</name>
    </gene>
    <organism evidence="3 23">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 23" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 23">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402460.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402696.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403279.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403338.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403367.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403488.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403675.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403901.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404114.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404497.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404598.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404666.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404732.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404753.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405156.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405185.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405552.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405604.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405854.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405930.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60971">
        <property type="protein sequence ID" value="ABB60971"/>
        <property type="gene ID" value="SDY_0789"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61205">
        <property type="protein sequence ID" value="ABB61205"/>
        <property type="gene ID" value="SDY_1040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61788">
        <property type="protein sequence ID" value="ABB61788"/>
        <property type="gene ID" value="SDY_1667"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61847">
        <property type="protein sequence ID" value="ABB61847"/>
        <property type="gene ID" value="SDY_1727"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61876">
        <property type="protein sequence ID" value="ABB61876"/>
        <property type="gene ID" value="SDY_1759"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61997">
        <property type="protein sequence ID" value="ABB61997"/>
        <property type="gene ID" value="SDY_1889"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62184">
        <property type="protein sequence ID" value="ABB62184"/>
        <property type="gene ID" value="SDY_2093"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62410">
        <property type="protein sequence ID" value="ABB62410"/>
        <property type="gene ID" value="SDY_2333"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62623">
        <property type="protein sequence ID" value="ABB62623"/>
        <property type="gene ID" value="SDY_2555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63006">
        <property type="protein sequence ID" value="ABB63006"/>
        <property type="gene ID" value="SDY_2983"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63107">
        <property type="protein sequence ID" value="ABB63107"/>
        <property type="gene ID" value="SDY_3091"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63175">
        <property type="protein sequence ID" value="ABB63175"/>
        <property type="gene ID" value="SDY_3162"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63241">
        <property type="protein sequence ID" value="ABB63241"/>
        <property type="gene ID" value="SDY_3233"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63262">
        <property type="protein sequence ID" value="ABB63262"/>
        <property type="gene ID" value="SDY_3261"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63665">
        <property type="protein sequence ID" value="ABB63665"/>
        <property type="gene ID" value="SDY_3704"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63694">
        <property type="protein sequence ID" value="ABB63694"/>
        <property type="gene ID" value="SDY_3738"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64061">
        <property type="protein sequence ID" value="ABB64061"/>
        <property type="gene ID" value="SDY_4152"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64113">
        <property type="protein sequence ID" value="ABB64113"/>
        <property type="gene ID" value="SDY_4209"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64363">
        <property type="protein sequence ID" value="ABB64363"/>
        <property type="gene ID" value="SDY_4487"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64439">
        <property type="protein sequence ID" value="ABB64439"/>
        <property type="gene ID" value="SDY_4576"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0789"/>
    <dbReference type="KEGG" id="sdy:SDY_1040"/>
    <dbReference type="KEGG" id="sdy:SDY_1667"/>
    <dbReference type="KEGG" id="sdy:SDY_1727"/>
    <dbReference type="KEGG" id="sdy:SDY_1759"/>
    <dbReference type="KEGG" id="sdy:SDY_1889"/>
    <dbReference type="KEGG" id="sdy:SDY_2093"/>
    <dbReference type="KEGG" id="sdy:SDY_2333"/>
    <dbReference type="KEGG" id="sdy:SDY_2555"/>
    <dbReference type="KEGG" id="sdy:SDY_2983"/>
    <dbReference type="KEGG" id="sdy:SDY_3091"/>
    <dbReference type="KEGG" id="sdy:SDY_3162"/>
    <dbReference type="KEGG" id="sdy:SDY_3233"/>
    <dbReference type="KEGG" id="sdy:SDY_3261"/>
    <dbReference type="KEGG" id="sdy:SDY_3704"/>
    <dbReference type="KEGG" id="sdy:SDY_3738"/>
    <dbReference type="KEGG" id="sdy:SDY_4152"/>
    <dbReference type="KEGG" id="sdy:SDY_4209"/>
    <dbReference type="KEGG" id="sdy:SDY_4487"/>
    <dbReference type="KEGG" id="sdy:SDY_4576"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1215"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB63175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB63241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB63262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB63665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB63694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABB64061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ABB64113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ABB64363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ABB64439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15322" checksum="E71E354A8DE0996B" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IB0</accession>
    <name>Q32IB0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">[Formate-C-acetyltransferase]-activating enzyme</fullName>
            <ecNumber evidence="5">1.97.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ybiY</name>
        <name evidence="13" type="ordered locus">SDY_0763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:19225"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12190"/>
            <dbReference type="Rhea" id="RHEA-COMP:12191"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
            <dbReference type="EC" id="1.97.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402436.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IB0"/>
    <dbReference type="STRING" id="300267.SDY_0763"/>
    <dbReference type="EnsemblBacteria" id="ABB60947">
        <property type="protein sequence ID" value="ABB60947"/>
        <property type="gene ID" value="SDY_0763"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0763"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.877"/>
    <dbReference type="HOGENOM" id="CLU_058969_0_1_6"/>
    <dbReference type="OMA" id="PWKYIEP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034465">
        <property type="entry name" value="Pyruvate_for-lyase_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00278">
        <property type="entry name" value="pyruvate_formate-lyase_activas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB60947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="308" mass="34153" checksum="6B79E67CFFB219EA" modified="2005-12-06" version="1">MFERNREATMIFNIQRYSTHDGPGIRTVVFLKGCSLGCRWCQNPESRARTQDLLYDARLCLEGCELCAKAAPDVIERALNGLLIHREKLTPEHLTALTDCCPTQALTVCGEVKSVEEIMATVLRDKPFYDRSGGGLTLSGGEPFMQLEMATALLQASHEAGIHTAVETCLHVPWKYIAPSLPYIDLFLADLKHVADAPFKQWTDGNAARVLDNLKKLAAAGKKIIIRVPLIQGFNADETAIKAITDFAADELHVGEIHFLPYHTLGINKYHLLNLPYDAPEKPLDVPELLDFAQQYACQKGLTAILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IB1</accession>
    <name>Q32IB1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-6-phosphate aldolase</fullName>
            <ecNumber evidence="7">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mipB</name>
        <name evidence="7" type="synonym">fsa</name>
        <name evidence="8" type="ordered locus">SDY_0762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodecamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transaldolase family. Type 3A subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IB1"/>
    <dbReference type="STRING" id="300267.SDY_0762"/>
    <dbReference type="EnsemblBacteria" id="ABB60946">
        <property type="protein sequence ID" value="ABB60946"/>
        <property type="gene ID" value="SDY_0762"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0762"/>
    <dbReference type="HOGENOM" id="CLU_079764_2_0_6"/>
    <dbReference type="OMA" id="VRHPMHV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00496">
        <property type="entry name" value="F6P_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023001">
        <property type="entry name" value="F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="244" mass="26120" checksum="92779ACE7F00E028" modified="2005-12-06" version="1">MRQLFREFSRDSLHSDKKYILRMVMELYLDTSDVVAVKALSRIFPLAGVTTNPSIIAAGKKPLEVVLPELHEAMGGQGRLFAQVMAITAEGMVNDARKLRSIIADIVVKVPVTAEGLAAIKMLKAEGIPTLGTAVYGAAQGLLSALAGAEYVAPYVNRIDAQAGSGIQTVTDLHQLLKMHAPQAKVLAASFKTPRQALDCLLAGCESITLPLDVAQQMISYPAVDAAVAKFEQDWQGAFGRTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ID5</accession>
    <name>Q32ID5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putrescine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potI</name>
        <name evidence="8" type="ordered locus">SDY_0738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001061658.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402411.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ID5"/>
    <dbReference type="SMR" id="Q32ID5"/>
    <dbReference type="STRING" id="300267.SDY_0738"/>
    <dbReference type="EnsemblBacteria" id="ABB60922">
        <property type="protein sequence ID" value="ABB60922"/>
        <property type="gene ID" value="SDY_0738"/>
    </dbReference>
    <dbReference type="GeneID" id="67413899"/>
    <dbReference type="KEGG" id="sdy:SDY_0738"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.852"/>
    <dbReference type="HOGENOM" id="CLU_016047_3_0_6"/>
    <dbReference type="OMA" id="FPMFVWG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="65"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="281" mass="30541" checksum="A1B557CE2FC7C9EB" modified="2005-12-06" version="1">MNNLPVVRSPWRIVILLLGFTFLYAPMLMLVIYSFNSSKLVTVWAGWSTRWYGELLRDDAMMSAVGLSLTIAACAATAAAILGTIAAVVLVRFGRFRGSNGFAFMITAPLVMPDVITGLSLLLLFVALAHAIGWPADRGMLTIWLAHVTFCTAYVAVVISSRLRELDRSIEEAAMDLGATPLKVFFVITLPMIMPAIISGWLLAFTLSLDDLVIASFVSGPGATTLPMLVFSSVRMGVNPEINALATLILGAVGIVGFIAWYLMARAEKQRIRDIQRARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IG4</accession>
    <name>Q32IG4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdate uptake regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">modE</name>
        <name evidence="7" type="ordered locus">SDY_0708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ModE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001147428.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402382.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IG4"/>
    <dbReference type="STRING" id="300267.SDY_0708"/>
    <dbReference type="EnsemblBacteria" id="ABB60893">
        <property type="protein sequence ID" value="ABB60893"/>
        <property type="gene ID" value="SDY_0708"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0708"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.819"/>
    <dbReference type="HOGENOM" id="CLU_087839_0_0_6"/>
    <dbReference type="OMA" id="SYKTAWH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016462">
        <property type="entry name" value="ModE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003725">
        <property type="entry name" value="ModE-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005763">
        <property type="entry name" value="Txn_reg_ModE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00637">
        <property type="entry name" value="ModE_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mop" evidence="6">
        <location>
            <begin position="124"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="6">
        <location>
            <begin position="196"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="262" mass="28243" checksum="876099F96DEFE8F1" modified="2005-12-06" version="1">MQAEILLTLKLQQKLFADPRRISLLKHIALSGSISQGAKDAGISYKSAWDAINEMNQLSEHILVERATGGKGGGGAALTRYGQRLIQLYDLLAQIQQKAFDVLSDDDALPLNSLLAAISRFSLQTSARNQWFGTITARDHDDVQQHVDVLLADGKTRLKVAITAQSGARLGLDEGKEVLILLKASWVGITQDEAVAQNADNQLPGIISHIERGAEQCEVLMALPDGQTLCATVPVNEATSLQQGQNVTAYFNADSVIIATLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J30</accession>
    <name>Q32J30_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0469</name>
        <name evidence="3" type="ordered locus">SDY_1028</name>
        <name evidence="4" type="ordered locus">SDY_1160</name>
        <name evidence="5" type="ordered locus">SDY_1315</name>
        <name evidence="6" type="ordered locus">SDY_2958</name>
        <name evidence="7" type="ordered locus">SDY_3860</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0469"/>
    <dbReference type="EnsemblBacteria" id="ABB60677">
        <property type="protein sequence ID" value="ABB60677"/>
        <property type="gene ID" value="SDY_0469"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61193">
        <property type="protein sequence ID" value="ABB61193"/>
        <property type="gene ID" value="SDY_1028"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61317">
        <property type="protein sequence ID" value="ABB61317"/>
        <property type="gene ID" value="SDY_1160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61462">
        <property type="protein sequence ID" value="ABB61462"/>
        <property type="gene ID" value="SDY_1315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62984">
        <property type="protein sequence ID" value="ABB62984"/>
        <property type="gene ID" value="SDY_2958"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63802">
        <property type="protein sequence ID" value="ABB63802"/>
        <property type="gene ID" value="SDY_3860"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0469"/>
    <dbReference type="KEGG" id="sdy:SDY_1028"/>
    <dbReference type="KEGG" id="sdy:SDY_1160"/>
    <dbReference type="KEGG" id="sdy:SDY_1315"/>
    <dbReference type="KEGG" id="sdy:SDY_2958"/>
    <dbReference type="KEGG" id="sdy:SDY_3860"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_1_6"/>
    <dbReference type="OMA" id="SPMESFW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="173" mass="20218" checksum="821FAB31AB203352" modified="2005-12-06" version="1">MTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKPGGVMFHSDQGSHYTSRQFRQLLWRYQIRQSMSRRGNCWDNSPMERFFRSLKNEWMPVVGYVSFSEAAHAITDYIVGYYSALRPHEYNGGLPPNESENRYWKNSNSVASFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JD8</accession>
    <name>Q32JD8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yaiA</name>
        <name evidence="2" type="ordered locus">SDY_0354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001142437.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402058.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JD8"/>
    <dbReference type="STRING" id="300267.SDY_0354"/>
    <dbReference type="EnsemblBacteria" id="ABB60569">
        <property type="protein sequence ID" value="ABB60569"/>
        <property type="gene ID" value="SDY_0354"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0354"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.415"/>
    <dbReference type="HOGENOM" id="CLU_195275_0_0_6"/>
    <dbReference type="OMA" id="YPREARI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032303">
        <property type="entry name" value="YaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038462">
        <property type="entry name" value="YaiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16362">
        <property type="entry name" value="YaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="63" mass="7237" checksum="127CD4C1ACFECA7A" modified="2005-12-06" version="1">MPTKPPYPREAYIVTIEKGKPGQTVTWYQLRADHPKPDSLISEHPTAQEAMDAKKRYEAPDKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JE0</accession>
    <name>PPNP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyrimidine/purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
            <ecNumber evidence="1">2.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Adenosine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cytidine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Guanosine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Inosine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Uridine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Xanthosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppnP</name>
        <name type="ordered locus">SDY_0352</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine + phosphate = alpha-D-ribose 1-phosphate + cytosine</text>
            <dbReference type="Rhea" id="RHEA:52540"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine</text>
            <dbReference type="Rhea" id="RHEA:16037"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + xanthosine = alpha-D-ribose 1-phosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:27638"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:18107"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nucleoside phosphorylase PpnP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EC" id="2.4.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000941939.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402056.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JE0"/>
    <dbReference type="SMR" id="Q32JE0"/>
    <dbReference type="STRING" id="300267.SDY_0352"/>
    <dbReference type="EnsemblBacteria" id="ABB60567">
        <property type="protein sequence ID" value="ABB60567"/>
        <property type="gene ID" value="SDY_0352"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0352"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.413"/>
    <dbReference type="HOGENOM" id="CLU_157874_0_0_6"/>
    <dbReference type="OMA" id="YHYICHF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047975">
        <property type="term" value="F:guanosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01537">
        <property type="entry name" value="Nucleos_phosphorylase_PpnP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009664">
        <property type="entry name" value="Ppnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36540">
        <property type="entry name" value="PTHR36540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06865">
        <property type="entry name" value="Ppnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000298730" description="Pyrimidine/purine nucleoside phosphorylase">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01537"/>
        </source>
    </evidence>
    <sequence length="94" mass="10261" checksum="2EDF5C0AFD9D5C49" modified="2005-12-06" version="1">MLQSNEYFSGKVKSIGFSSSSTGRASVGVMVEGEYTFSTAEPEEMTVINGALNVLLPDATDWQVYEAGSVFNVPGHSEFHLQVAEPTSYLCRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JF4</accession>
    <name>Q32JF4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proline permease transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proY</name>
        <name evidence="8" type="ordered locus">SDY_0335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295329.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402042.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JF4"/>
    <dbReference type="SMR" id="Q32JF4"/>
    <dbReference type="STRING" id="300267.SDY_0335"/>
    <dbReference type="EnsemblBacteria" id="ABB60553">
        <property type="protein sequence ID" value="ABB60553"/>
        <property type="gene ID" value="SDY_0335"/>
    </dbReference>
    <dbReference type="GeneID" id="66671299"/>
    <dbReference type="KEGG" id="sdy:SDY_0335"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.386"/>
    <dbReference type="HOGENOM" id="CLU_007946_9_3_6"/>
    <dbReference type="OMA" id="PHWVWVL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="15"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="457" mass="50216" checksum="5F2819526EA06BD8" modified="2005-12-06" version="1">MESKNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGIAAYIIMRALGEMSVHNPAASSFSRYAQENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPTVPHWIWVLSVVLIICAVNLMSVKVFGELEFWFSFFKVATIIIMIVAGFGIIIWGIGNGGQPTGIHNLWSNGGFFSNGWLGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIYPWNQVGTAGSPFVLTFQHMGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPKIFSKTSRRGIPWVTVLVMTTALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPGGVATTIGGLIFLLFIIGLIGYHPDTRISLYVGFAWIVVLLIGWMFKRRHDRQLAENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JF6</accession>
    <name>Q32JF6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JF6"/>
    <dbReference type="EnsemblBacteria" id="ABB60551">
        <property type="protein sequence ID" value="ABB60551"/>
        <property type="gene ID" value="SDY_0332"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0332"/>
    <dbReference type="HOGENOM" id="CLU_203300_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="61" mass="7007" checksum="9B2207D4767B1E63" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGDWPTLLVPVPMKPAGNYWHCLRHSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JG3</accession>
    <name>Q32JG3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secF</name>
        <name evidence="10" type="ordered locus">SDY_0325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000046643.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402033.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JG3"/>
    <dbReference type="STRING" id="300267.SDY_0325"/>
    <dbReference type="EnsemblBacteria" id="ABB60544">
        <property type="protein sequence ID" value="ABB60544"/>
        <property type="gene ID" value="SDY_0325"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0325"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.374"/>
    <dbReference type="HOGENOM" id="CLU_050012_1_0_6"/>
    <dbReference type="OMA" id="AFEWRMA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="323" mass="35412" checksum="8CC8A96B2FE58DF3" modified="2005-12-06" version="1">MAQEYTVEQLNHGRKVYDFMRWDYWAFGISGLLLIAAIVIMGVRGFNWGLDFTGGTVIEITLEKPAEIDVMRDALQKAGFEEPMLQNFGSSHDIMVRMPPAEGETGGQVLGSQVLKVINESTNQNAAVKRIEFVGPSVGADLAQTGAMALMTALLSILVYVGFRFEWRLAAGVVIALAHDVIITLGILSLFHIEIDLTIVASLMSVIGYSLNDSIVVSDRIRENFRKIRRGTPYEIFNVSLTQTLHRTLITSGTTLMVILMLYLFGGPVLEGFSLTMLIGVSIGTASSIYVASALALKLGMKREHMLQQKVEKEGADQPSILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K52</accession>
    <name>Q32K52_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yaaU</name>
        <name evidence="8" type="ordered locus">SDY_0067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K52"/>
    <dbReference type="STRING" id="300267.SDY_0067"/>
    <dbReference type="EnsemblBacteria" id="ABB60305">
        <property type="protein sequence ID" value="ABB60305"/>
        <property type="gene ID" value="SDY_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0067"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_6"/>
    <dbReference type="OMA" id="VVYLYCT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="19"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="306" mass="34082" checksum="4A1DB1E4A4BBE4E2" modified="2005-12-06" version="1">MQPSRNFDDLKFSSIHRRILLWGSGGPFLDGYVLVMIGMALEQLTPALKLDADWIGLLGAGTLAGLFVGTSLFGYISDKVGRRKMFLIDIIAIGVISVATMFVSSPVELLVMRVLIGIVIGADYPIATSMITEFSSTRQRAFSISFIAAMWYVGATCADLVGYWLYDVEGGWRWMLGSAAIPCLLILIGRFELPESPRWLLRKGRVKECEEMMIKLFGEPVAFDEEQPQQTRFRDLFNRRHFPFVLFVAAIWTCQVIPMFAIYTFGPQIIGLLGLGVGKNVALGNVVISLFFMLGCIPPMLWLNTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K67</accession>
    <name>RIHC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-specific ribonucleoside hydrolase RihC</fullName>
            <ecNumber evidence="1">3.2.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Purine/pyrimidine ribonucleoside hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rihC</name>
        <name type="ordered locus">SDY_0052</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family. RihC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001239123.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401779.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K67"/>
    <dbReference type="SMR" id="Q32K67"/>
    <dbReference type="STRING" id="300267.SDY_0052"/>
    <dbReference type="EnsemblBacteria" id="ABB60290">
        <property type="protein sequence ID" value="ABB60290"/>
        <property type="gene ID" value="SDY_0052"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0052"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.56"/>
    <dbReference type="HOGENOM" id="CLU_036838_2_2_6"/>
    <dbReference type="OMA" id="TPVAEWN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045437">
        <property type="term" value="F:uridine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01432">
        <property type="entry name" value="Nucleosid_hydro_RihC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015910">
        <property type="entry name" value="I/U_nuclsd_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022976">
        <property type="entry name" value="Nucleosid_hydro_RihC_nonspecif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01247">
        <property type="entry name" value="IUNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000024409" description="Non-specific ribonucleoside hydrolase RihC">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01432"/>
        </source>
    </evidence>
    <sequence length="304" mass="32561" checksum="55F8C0FB370ED472" modified="2005-12-06" version="1">MRLPIFLDTDPGIDDAVAIAAAIFAPELDLQLMTTVAGNVSVEKTTRNALQLLHFWNAEIPLAQGAAVPLVRAPRDAASVHGESGMAGYDFVEHNRKPLGIPAFLAIRDALMCAPEPVTLVAIGPLTNIALLLSQCPECKPYIRRLVIMGGSAGRGNCTPNAEFNIAADPEAAACVFRSGIEIVMCGLDVTNQAILTPDYLATLPELNRTGKMLHALFSHYRSGSMQSGLRMHDLCAIAWLVRPDLFTLKPCFVAVETQGEFTSGTTVVDIDGCRGKPANVQVALDLNVKGFQQWVPEVLALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Q8</accession>
    <name>Q326Q8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-secreting ATPase</fullName>
            <ecNumber evidence="7">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">spa47</name>
        <name evidence="9" type="ordered locus">SDY_P187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Sd197</strain>
            <plasmid evidence="10">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="7"/>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000122614.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406188.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Q8"/>
    <dbReference type="EnsemblBacteria" id="ABB64700">
        <property type="protein sequence ID" value="ABB64700"/>
        <property type="gene ID" value="SDY_P187"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P187"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5739"/>
    <dbReference type="HOGENOM" id="CLU_022398_5_1_6"/>
    <dbReference type="OMA" id="MDSATRF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="151"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="430" mass="47476" checksum="034F5006DF332B79" modified="2005-12-06" version="1">MSYTKLLTQLSFPNKISGPILETSLSDVSIGEICNIQAGIESNEIVARAQVVGFHDEKTILSLIGNSRGLSRQTLIKPTAQFLHTQVGRGLLGAVVNPLGEVTDKFAVTDNSEILYRPVDNAPPLYSERAAIEKPFLTGVKVIDSLLTCGEGQRMGIFASAGCGKTFLMNMLIEHSGADIYVIGLIGERGREVTETVDYLKNSEKKSRCVLVYATSDYSSVDRCNAAYIATAIAEFFRTEGHKVALFIDSLTRYARALRDVALAAGESPARRGYPVSVFDSLPRLLERPGKLKAGGSITAFYTVLLEDDDFADPLAEEVRSILDGHIYLSRNLAQKGQFPAIDSLKSISRVFTQVVDEKHRIMAAAFRELLSEIEELRTIIDFGEYKPGENASQDKIYNKISVVESFLKQDYRLGFTYEQTMELIGETIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q327J1</accession>
    <name>Q327J1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OspB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ospB</name>
        <name evidence="1" type="ordered locus">SDY_P003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406005.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327J1"/>
    <dbReference type="EnsemblBacteria" id="ABB64517">
        <property type="protein sequence ID" value="ABB64517"/>
        <property type="gene ID" value="SDY_P003"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P003"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5529"/>
    <dbReference type="HOGENOM" id="CLU_071017_0_0_6"/>
    <dbReference type="OMA" id="HIVITEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="227" mass="25661" checksum="5010829395E76356" modified="2005-12-06" version="1">MGQQIPRVFKNKMLYDYVFKNEKSKNDFLKMAESWLPQSEPVVINNDDDALNAAAYFSVKKAKIKTVNDTDFKEYNKVYILGHGSPGSHQLGLGSELIDVQTIISRMKDCGILNVKDIRFTSCGSADKVAPKDFNNAPAESLSCILNSLPFFKEKESLLEQIKKHLENDESLSDGLKISGYHGYGVHYGQELFPYSHYRSTSIPADPEHTVKRSSQKKTFIINKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q327R7</accession>
    <name>Q327R7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405929.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327R7"/>
    <dbReference type="STRING" id="300267.SDY_4574"/>
    <dbReference type="EnsemblBacteria" id="ABB64438">
        <property type="protein sequence ID" value="ABB64438"/>
        <property type="gene ID" value="SDY_4574"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4574"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5414"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27486" checksum="10EDBAA9E42B29D0" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGECMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q327S1</accession>
    <name>Q327S1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PapC_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SDY_4570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell outer membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the fimbrial export usher family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405925.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327S1"/>
    <dbReference type="STRING" id="300267.SDY_4570"/>
    <dbReference type="EnsemblBacteria" id="ABB64434">
        <property type="protein sequence ID" value="ABB64434"/>
        <property type="gene ID" value="SDY_4570"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4570"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5410"/>
    <dbReference type="HOGENOM" id="CLU_009120_0_5_6"/>
    <dbReference type="OMA" id="TRIRDCK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015473">
        <property type="term" value="F:fimbrial usher porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000015">
        <property type="entry name" value="Fimb_usher"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018030">
        <property type="entry name" value="Fimbrial_membr_usher_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025885">
        <property type="entry name" value="PapC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037224">
        <property type="entry name" value="PapC_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30451">
        <property type="entry name" value="PTHR30451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13954">
        <property type="entry name" value="PapC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00577">
        <property type="entry name" value="Usher"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141729">
        <property type="entry name" value="SSF141729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01151">
        <property type="entry name" value="FIMBRIAL_USHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="9" id="KW-1029">Fimbrium biogenesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PapC_N" evidence="10">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB64434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="403" mass="44235" checksum="4E528109BABDFDD6" modified="2005-12-06" version="1">METRTLEFEEATEAQRKAMGESLVPCLSRTQLVEMGVRVESFPALNLVPAEACVPFDEIIPQASSHFDFSEQKLVLSFPQAAMHQVARGTVPESLWDEGIPALLLDYSFSGSNSEYDSTGSSSSYVDDNGTVHHDDGKDTLKSDSYYLNLRSGLNLGAWRLRNYSTWSHSGGKAQWDNIGTSLSRAIIPFKAQLTMGDTATAGDIFDSVQMRGAMLASDEEMLPDSQRGFAPIVRGIAKSNAEVSIEQNGYVIYRTYVQPGAFEINDLYPTANSGDLTVKADGSEQRFIQPFSSVPIFQREGHLKYSFAAGEYQAGNYDSASPRFGQLDLIYGLPWGMTAYGGVLISNNYNAFALGIGKNFGYIGAISIDVTQAKSELNNDRDSQGQSYRFLYSKSFESGTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q327U4</accession>
    <name>Q327U4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_4537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405902.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327U4"/>
    <dbReference type="EnsemblBacteria" id="ABB64411">
        <property type="protein sequence ID" value="ABB64411"/>
        <property type="gene ID" value="SDY_4537"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4537"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5362"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14858" checksum="F3D3807D6C754B56" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVGLHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q327V8</accession>
    <name>Q327V8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">qor</name>
        <name evidence="3" type="ordered locus">SDY_4523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000235509.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405888.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327V8"/>
    <dbReference type="SMR" id="Q327V8"/>
    <dbReference type="STRING" id="300267.SDY_4523"/>
    <dbReference type="EnsemblBacteria" id="ABB64397">
        <property type="protein sequence ID" value="ABB64397"/>
        <property type="gene ID" value="SDY_4523"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4523"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5346"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_6"/>
    <dbReference type="OMA" id="THIATRE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="11"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="327" mass="35171" checksum="A63DF91499ABF3B2" modified="2005-12-06" version="1">MATRIEFHKHGGPEVLQAVEFTPADPAENEIQVENKAIGINFIDTYIRSGLYPPPSLPSGLGTEAAGIVSKVGSGVKHIKAGDRVVYAQSALGAYSSVHNIIADKAAILPAAISFEQAAASFLKGLTVYYLLRKTYEIKPDEQFLFHAAAGGVGLIACQWAKALGAKLIGTVGTAQKAQSALKAGAWQVINYREENLVERLKEITGGKKVRVVYDSVGRDTWERSLDCLQRRGLMVSFGNSSGAVTGVNLGILNQKGSLYVTRPSLQGYITTREELTEASNELFSLIASGVIKVDVAEQQKYPLKDAQRAHEILESRATQGSSLLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q328A2</accession>
    <name>Q328A2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative positive transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">evgA</name>
        <name evidence="5" type="ordered locus">SDY_4477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000991370.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405844.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328A2"/>
    <dbReference type="SMR" id="Q328A2"/>
    <dbReference type="STRING" id="300267.SDY_4477"/>
    <dbReference type="EnsemblBacteria" id="ABB64353">
        <property type="protein sequence ID" value="ABB64353"/>
        <property type="gene ID" value="SDY_4477"/>
    </dbReference>
    <dbReference type="GeneID" id="66673761"/>
    <dbReference type="KEGG" id="sdy:SDY_4477"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5287"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_6"/>
    <dbReference type="OMA" id="YKKRLMQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="204" mass="22690" checksum="E68F932F3729FBBB" modified="2005-12-06" version="1">MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q328B5</accession>
    <name>Q328B5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GGACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytfP</name>
        <name evidence="2" type="ordered locus">SDY_4459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001219160.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405831.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328B5"/>
    <dbReference type="SMR" id="Q328B5"/>
    <dbReference type="STRING" id="300267.SDY_4459"/>
    <dbReference type="EnsemblBacteria" id="ABB64340">
        <property type="protein sequence ID" value="ABB64340"/>
        <property type="gene ID" value="SDY_4459"/>
    </dbReference>
    <dbReference type="GeneID" id="66671859"/>
    <dbReference type="KEGG" id="sdy:SDY_4459"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5260"/>
    <dbReference type="HOGENOM" id="CLU_083466_5_2_6"/>
    <dbReference type="OMA" id="WIYLYQD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="1">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="113" mass="12866" checksum="A320C9DC94607CF8" modified="2005-12-06" version="1">MRIFVYGSLRHKQGNSHWMTNAQLLGDFSIDNYQLYSLGHYPGAVPGNGTVHGEVYRIDNATLAELDALRTRGGEYARQLIQTPYGSAWMYVYQRPVDGLKLIESGDWLDRDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q328E0</accession>
    <name>PSD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="1">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="1">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="1" type="primary">psd</name>
        <name type="ordered locus">SDY_4432</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="1">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000934923.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405806.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328E0"/>
    <dbReference type="SMR" id="Q328E0"/>
    <dbReference type="STRING" id="300267.SDY_4432"/>
    <dbReference type="EnsemblBacteria" id="ABB64315">
        <property type="protein sequence ID" value="ABB64315"/>
        <property type="gene ID" value="SDY_4432"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4432"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5230"/>
    <dbReference type="HOGENOM" id="CLU_029061_4_1_6"/>
    <dbReference type="OMA" id="KDYHHYH"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00662">
        <property type="entry name" value="PS_decarb_PSD_B_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033178">
        <property type="entry name" value="PSD_type1_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PTHR10067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_0000262159" description="Phosphatidylserine decarboxylase beta chain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000262160" description="Phosphatidylserine decarboxylase alpha chain" evidence="1">
        <location>
            <begin position="254"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="1">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00662"/>
        </source>
    </evidence>
    <sequence length="322" mass="35983" checksum="45195A6693480599" modified="2005-12-06" version="1">MLNSFKLSLQYILPKLWLTRLAGWGASKRAGWLTKLVIDLFVKYYKVDMKEAQKPDTASYRTFNEFFVRPLRDEVRPIDTDPNVLVMPADGVISQLGKIEEDKILQAKGHNYSLEALLAGNYLMADLFRNGTFVTTYLSPRDYHRVHMPCNGILREMIYVPGDLFSVNHLTAQNVPNLFARNERVICLFDTEFGPMAQILVGATIVGSIETVWAGTITPPREGIIKRWTWPAGENDGSVALLKGQEMGRFKLGSTVINLFAPGKVNLVEQLESLSVTKIGQPLAVSTETFVTPDAEPAPLPAEEIEAEHYASPLVDDKKDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q328G6</accession>
    <name>Q328G6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjfM</name>
        <name evidence="2" type="ordered locus">SDY_4402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000101670.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405780.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328G6"/>
    <dbReference type="STRING" id="300267.SDY_4402"/>
    <dbReference type="EnsemblBacteria" id="ABB64289">
        <property type="protein sequence ID" value="ABB64289"/>
        <property type="gene ID" value="SDY_4402"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4402"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5199"/>
    <dbReference type="HOGENOM" id="CLU_095624_1_0_6"/>
    <dbReference type="OMA" id="WDACSTA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009576">
        <property type="entry name" value="Biofilm_formation_YgiB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06693">
        <property type="entry name" value="DUF1190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="212" mass="23358" checksum="B8897D559FA79351" modified="2005-12-06" version="1">MARKRKSRNNSKIGHGAISRIGRPNNPFEPRRNRYAQKYLTLALMGGAAFFVLKGCGDSGDVDNDGDGTFYSTVQDCIDDGNNADICARGWNNAKAAFYADVPKNMTQQNCQSKYENCYYDNVEQSWIPVVSGFLLSRVIRKDRDEPFVYNSGGSSFASRPVWRNTSGDYSWRSGSGKKESYSSGGFTTKKASTVSRGGYGRSSSARGHWGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q328H8</accession>
    <name>EFP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor P</fullName>
            <shortName evidence="1">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">efp</name>
        <name type="ordered locus">SDY_4390</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Is beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC. Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety would extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. The hydroxylation of the C5 position on Lys-34 would allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000257278.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405768.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328H8"/>
    <dbReference type="SMR" id="Q328H8"/>
    <dbReference type="STRING" id="300267.SDY_4390"/>
    <dbReference type="EnsemblBacteria" id="ABB64277">
        <property type="protein sequence ID" value="ABB64277"/>
        <property type="gene ID" value="SDY_4390"/>
    </dbReference>
    <dbReference type="GeneID" id="67414765"/>
    <dbReference type="KEGG" id="sdy:SDY_4390"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5185"/>
    <dbReference type="HOGENOM" id="CLU_074944_0_0_6"/>
    <dbReference type="OMA" id="WSVVEFQ"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0379">Hydroxylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000010856" description="Elongation factor P">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(3,6-diaminohexanoyl)-5-hydroxylysine" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <sequence length="188" mass="20591" checksum="E36E136D4399460F" modified="2005-12-06" version="1">MATYYSNDFRAGLKIMLDGEPYAVEASEFVKPGKGQAFARVKLRRLLTGTRVEKTFKSTDSAEGADVVDMNLTYLYNDGEFWHFMNNETFEQLSADAKAIGDNAKWLLDQAECIVTLWNGQPISVTPPNFVELEIVDTDPGLKGDTAGTGGKPATLSTGAVVKVPLFVQIGEVIKVDTRSGEYVSRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q328J0</accession>
    <name>Q328J0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter of D-alanine, D-serine, and glycine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cycA</name>
        <name evidence="8" type="ordered locus">SDY_4378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000228346.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405756.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328J0"/>
    <dbReference type="SMR" id="Q328J0"/>
    <dbReference type="STRING" id="300267.SDY_4378"/>
    <dbReference type="EnsemblBacteria" id="ABB64265">
        <property type="protein sequence ID" value="ABB64265"/>
        <property type="gene ID" value="SDY_4378"/>
    </dbReference>
    <dbReference type="GeneID" id="58461523"/>
    <dbReference type="KEGG" id="sdy:SDY_4378"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5170"/>
    <dbReference type="HOGENOM" id="CLU_007946_9_3_6"/>
    <dbReference type="OMA" id="FTHLWND"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="27"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="470" mass="51660" checksum="F9279E48D838EAF8" modified="2005-12-06" version="1">MVDQVKVVADDQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPDLSDWVASLAVIVLLLTLNLATVKMFGEMEFWFAMIKIVAIVSLIVVGLVMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKDPEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQRPHLHEKSIYKMPLGKLMCWVCMAFFVFVVVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q328L5</accession>
    <name>Q328L5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yiaF</name>
        <name evidence="1" type="ordered locus">SDY_4349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405731.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328L5"/>
    <dbReference type="STRING" id="300267.SDY_4349"/>
    <dbReference type="EnsemblBacteria" id="ABB64240">
        <property type="protein sequence ID" value="ABB64240"/>
        <property type="gene ID" value="SDY_4349"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4349"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5133"/>
    <dbReference type="HOGENOM" id="CLU_086363_0_0_6"/>
    <dbReference type="OMA" id="KMQADSS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021413">
        <property type="entry name" value="DUF3053"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11254">
        <property type="entry name" value="DUF3053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="276" mass="30159" checksum="4B12A77C0A589A59" modified="2005-12-06" version="1">MILPGRLRRKGILQACPGLSLSRQTRVCRCALFLGERSKKMATGKSCSRWFAPLAALLMVVSLSGCFDKEGDQRKAFIDFLQNTVMRSGERLPTLTADQKKQFGPFVSDYAILYGYSQQVNQAMDSGLRPVVDSVNAIRVPQDYVTQSGPLREMNGSLGVLAQQLQNAKLQADAAHSALKQSDDLKPVFDQAFTKVVTTPADALQPLIPAAQTFTQQLVMVGDYIAQQGTQVSFVANGIQFPTSQQASEYNKLIAPLPAQHQAFNQAWTTAVTATQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q328U1</accession>
    <name>PYRI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrI</name>
        <name type="ordered locus">SDY_4263</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Contains catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000148580.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405655.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328U1"/>
    <dbReference type="SMR" id="Q328U1"/>
    <dbReference type="STRING" id="300267.SDY_4263"/>
    <dbReference type="EnsemblBacteria" id="ABB64164">
        <property type="protein sequence ID" value="ABB64164"/>
        <property type="gene ID" value="SDY_4263"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4263"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5026"/>
    <dbReference type="HOGENOM" id="CLU_128576_0_0_6"/>
    <dbReference type="OMA" id="CPNRNCI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00002">
        <property type="entry name" value="Asp_carb_tr_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00240">
        <property type="entry name" value="ATCase_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000000049" description="Aspartate carbamoyltransferase regulatory chain">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00002"/>
        </source>
    </evidence>
    <sequence length="153" mass="17078" checksum="81BE82E814E549EA" modified="2005-12-06" version="1">MTHDNKLQVEAIKRGTVIDHIPAQIGFKLLSLFKLTETDQRITIGLNLPSGEMGRKDLIKIENTFLSEDQVDQLALYAPQATVNRIDNYEVVGKSRPSLPERIDNVLVCPNSNCISHAEPVSSSFAVLKRANDIALKCKYCEKEFSHNVVLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q328W5</accession>
    <name>Q328W5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fer4_19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjdI</name>
        <name evidence="2" type="ordered locus">SDY_4239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000371712.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405631.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328W5"/>
    <dbReference type="STRING" id="300267.SDY_4239"/>
    <dbReference type="EnsemblBacteria" id="ABB64140">
        <property type="protein sequence ID" value="ABB64140"/>
        <property type="gene ID" value="SDY_4239"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4239"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4993"/>
    <dbReference type="HOGENOM" id="CLU_139698_2_0_6"/>
    <dbReference type="OMA" id="YFNTNVC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010693">
        <property type="entry name" value="Divergent_4Fe-4S_mono-cluster"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06902">
        <property type="entry name" value="Fer4_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_19" evidence="1">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="76" mass="8566" checksum="F32C085C008B27C1" modified="2005-12-06" version="1">MDQALLDGGYRCYTGEKIDVYFNTAICQHSGNCVRGNGNLFNLKRKPWIMPDEVDVATVVKVIDTCPSSALKYRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Z6</accession>
    <name>Q328Z6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Z6"/>
    <dbReference type="EnsemblBacteria" id="ABB64109">
        <property type="protein sequence ID" value="ABB64109"/>
        <property type="gene ID" value="SDY_4205"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4205"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="ARSTHYY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32044" checksum="367B1F754868A102" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKDSNQRWCSDGFEFCCDNGERLRVTFVLDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q329A0</accession>
    <name>Q329A0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yieE</name>
        <name evidence="1" type="ordered locus">SDY_4201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405596.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329A0"/>
    <dbReference type="STRING" id="300267.SDY_4201"/>
    <dbReference type="EnsemblBacteria" id="ABB64105">
        <property type="protein sequence ID" value="ABB64105"/>
        <property type="gene ID" value="SDY_4201"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4201"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4941"/>
    <dbReference type="HOGENOM" id="CLU_096413_0_0_6"/>
    <dbReference type="OMA" id="SHFARWA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="253" mass="28191" checksum="5A4418BF7CD73CF6" modified="2005-12-06" version="1">MERKMATHFARGILTEGHLISVRLPSQCHQEARNIPPHRQSRFLASRGLLAELMFMLYGIGELPEIVTLPKGKPVFSDKNLPSFSISYAGNMVGVALTTEGECGLDMELQRATRGFHSPHAPDNHTFSSNESLWISKQNDPNEARAQLITLRRSVLKLTGDVLNDDPRDLQLLPIAGRLKCAHVNHVEALCDAEDVLVWSVAVTPTIEKLSVWELDGKHGWKSLPDIHSRANNPTSRMMRFAQLSTVKAFSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q329C1</accession>
    <name>Q329C1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yidA</name>
        <name evidence="3" type="ordered locus">SDY_4179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000985557.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405575.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329C1"/>
    <dbReference type="STRING" id="300267.SDY_4179"/>
    <dbReference type="EnsemblBacteria" id="ABB64084">
        <property type="protein sequence ID" value="ABB64084"/>
        <property type="gene ID" value="SDY_4179"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4179"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4916"/>
    <dbReference type="HOGENOM" id="CLU_044146_0_1_6"/>
    <dbReference type="OMA" id="GAWIQDP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="270" mass="29751" checksum="F4EBEEBE5A51E45B" modified="2005-12-06" version="1">MAIKLIAIDMDGTLLLPDHTISPAVKNAIAAARARGVNVVLTTGRPYAGVHNYLKELHMEQPGDYCITYNGALVQKAADGSTVAQTALSYDDYRFLEKLSREVGSHFHTLDRTTLYTANRDISYYTVHESFVATIPLVFCEAEKMDPNTQFLKVMMIDEPAILDQAIARIPQEVKEKYTVLKSAPYFLEILDKRVNKGTGVKSLADVLGIKPEEIMAIGDQENDIAMIEYAGVGVAMDNAIPSVKEVANFVTKSNLEDGVAFAIEKYVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q329C4</accession>
    <name>Q329C4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidR</name>
        <name evidence="1" type="ordered locus">SDY_4175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405572.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329C4"/>
    <dbReference type="STRING" id="300267.SDY_4175"/>
    <dbReference type="EnsemblBacteria" id="ABB64081">
        <property type="protein sequence ID" value="ABB64081"/>
        <property type="gene ID" value="SDY_4175"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4175"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4910"/>
    <dbReference type="HOGENOM" id="CLU_054731_0_0_6"/>
    <dbReference type="OMA" id="YAFIHGP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022223">
        <property type="entry name" value="DUF3748"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12566">
        <property type="entry name" value="DUF3748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="414" mass="45997" checksum="8D4F93A7658E04AA" modified="2005-12-06" version="1">MMAGTVLYQDHAMKQITFAPRNHLLTNTWTPDSQWLVFDVRPSGASFTGETIERVNIHTGEVEVIYRASQGAYVGVVTVHLKSEKYVFIHGPENPDETWHYDFHHRRGVIAEGGKVSNLDAMDIIAPYTPGALRGGSHVHVFSPNGERVSFTYNDHVMHERSPALDLRNVGVAAPFGPVNVQKQHPREYSGSHWCALVSKTTPTPQPGSDEINRAYEEGWVGNHALAFIGDTLSPKGEKVPELFIVELPQDEAGWKAAGDAPLSGTETTLPAPPRGVVQRRLTFTHHRAYPGLVNIPRHWVRCNPQATQIAFLMRDDNGIVQLWLISPQGGEPRQLTHNKTDIQSAFNWHPSGEWLGFVLGNRIACAHAQSGEVEYLTENHANPPSADAVVFSPDGQWLAWMEGGQLWITETDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q329D6</accession>
    <name>Q329D6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yidH</name>
        <name evidence="7" type="ordered locus">SDY_4160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000703959.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405560.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329D6"/>
    <dbReference type="SMR" id="Q329D6"/>
    <dbReference type="STRING" id="300267.SDY_4160"/>
    <dbReference type="EnsemblBacteria" id="ABB64069">
        <property type="protein sequence ID" value="ABB64069"/>
        <property type="gene ID" value="SDY_4160"/>
    </dbReference>
    <dbReference type="GeneID" id="66672426"/>
    <dbReference type="KEGG" id="sdy:SDY_4160"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4889"/>
    <dbReference type="HOGENOM" id="CLU_053359_4_1_6"/>
    <dbReference type="OMA" id="NHWVRCE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="115" mass="12779" checksum="59E08E0F3EA7125A" modified="2005-12-06" version="1">MKISRLGEAPDYRFSLANERTFLAWIRTALGFLAAGVGLDQLAPDFATPVIRELLALLLCLFSGGLAMYGYLRWLRNEKAMRLKEDLPYTNSLLIISLILMVVAVIVMGLVLYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q329D8</accession>
    <name>Q329D8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidF</name>
        <name evidence="1" type="ordered locus">SDY_4158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000148047.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405558.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329D8"/>
    <dbReference type="STRING" id="300267.SDY_4158"/>
    <dbReference type="EnsemblBacteria" id="ABB64067">
        <property type="protein sequence ID" value="ABB64067"/>
        <property type="gene ID" value="SDY_4158"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4158"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4887"/>
    <dbReference type="HOGENOM" id="CLU_138420_0_0_6"/>
    <dbReference type="OMA" id="CEGYQAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="165" mass="19233" checksum="3E164C92F1CFF33B" modified="2005-12-06" version="1">MTGSQVIDAEEDRHKLVVEYKDALQPADFYHNFKQRGIRSVQLIPHLEFDDRGDLTAASVTAELWGKFLIALFECWVRADISRISIELFDATLQKWCGSENPQSRRDCQACDWHRLCPHAREETPDNVLCAGYQAFYSYSAPHMRVMRDLIKQHRSPMELMTMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q329M8</accession>
    <name>Q329M8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide 1,3-galactosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfaI</name>
        <name evidence="2" type="ordered locus">SDY_4059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001272728.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405468.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329M8"/>
    <dbReference type="STRING" id="300267.SDY_4059"/>
    <dbReference type="CAZy" id="GT8">
        <property type="family name" value="Glycosyltransferase Family 8"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63977">
        <property type="protein sequence ID" value="ABB63977"/>
        <property type="gene ID" value="SDY_4059"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4059"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4775"/>
    <dbReference type="HOGENOM" id="CLU_050833_5_0_6"/>
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    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008918">
        <property type="term" value="F:lipopolysaccharide 3-alpha-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
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        <property type="entry name" value="Glyco_transf_8N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08437">
        <property type="entry name" value="Glyco_transf_8C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_8C" evidence="1">
        <location>
            <begin position="279"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="338" mass="38771" checksum="179EED5DB3E78757" modified="2005-12-06" version="1">MSAHYFNPQEMINKTIIFDERPAASVASSFHVAYGIDKNFLFGCGVSITSVLLHNNDVSFVFHVFIDDIPEADIQRLAQLAKSYRTCIQIHLVNCERLKALPTTKNWSIAMYFRFVIADYFIDQQDKILYLDADIACQGNLKPLITMDLANNVAAVVTERDANWWSLRGQSLQCNELAKGYFNSGVLLINTLAWAQESVSAKAMSMLADKAIVSRLTYMDQDILNLILLGKVKFIDAKYNTQFSLNYELKKSFVCPINDETVLIHYVGPTKPWHYWASYPSAQPFIKAKETSPWKNEPLMRPANSNYARYCAKHNFKQNKPINGIMNYIYYFYLKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A05</accession>
    <name>Q32A05_SHIDS</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="primary">yigM</name>
        <name evidence="7" type="ordered locus">SDY_3916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Gammaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A05"/>
    <dbReference type="STRING" id="300267.SDY_3916"/>
    <dbReference type="EnsemblBacteria" id="ABB63850">
        <property type="protein sequence ID" value="ABB63850"/>
        <property type="gene ID" value="SDY_3916"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3916"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4624"/>
    <dbReference type="HOGENOM" id="CLU_085269_0_0_6"/>
    <dbReference type="OMA" id="RFNPWAL"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004779">
        <property type="entry name" value="CO/AA/NH_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00950">
        <property type="entry name" value="2A78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="139"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="299" mass="33761" checksum="A8F8563E1DA0BF65" modified="2005-12-06" version="1">MALLIITTILWAFSFSFYGEYLAGHVDSYFAVLVRVGLAALVFLPFLRTRGNSLKTVGLYMLVGAMQLGVMYMLSFRAYLYLTVSELLLFTVLTPLYITLIYDIMSKRRLRWGYAFSALLAVIGAGIIRYDQVTDHFWTGLLLVQLSNITFAIGMVGYKRLMETRPMPQHNAFAWFYLGAFLVAVIAWFLLGNAQKMPQTTFQWGILVFLGVVASGIGYFMWNYGATQVDAGTLGIMNNMHVPAGLLVNLAIWHQQPHWPTFITGALVILASLWVHRKWVAPRSSQTADDRRRDCALSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AC0</accession>
    <name>Q32AC0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yijP</name>
        <name evidence="8" type="ordered locus">SDY_3790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405226.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AC0"/>
    <dbReference type="STRING" id="300267.SDY_3790"/>
    <dbReference type="EnsemblBacteria" id="ABB63735">
        <property type="protein sequence ID" value="ABB63735"/>
        <property type="gene ID" value="SDY_3790"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3790"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4479"/>
    <dbReference type="HOGENOM" id="CLU_018534_3_3_6"/>
    <dbReference type="OMA" id="PMYTIPF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040423">
        <property type="entry name" value="PEA_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30443">
        <property type="entry name" value="PTHR30443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="7">
        <location>
            <begin position="238"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="577" mass="66624" checksum="91B02AC9CDB44C2F" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AD7</accession>
    <name>Q32AD7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yiiX</name>
        <name evidence="2" type="ordered locus">SDY_3772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000702308.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405209.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AD7"/>
    <dbReference type="STRING" id="300267.SDY_3772"/>
    <dbReference type="EnsemblBacteria" id="ABB63718">
        <property type="protein sequence ID" value="ABB63718"/>
        <property type="gene ID" value="SDY_3772"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3772"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4461"/>
    <dbReference type="HOGENOM" id="CLU_104117_0_0_6"/>
    <dbReference type="OMA" id="CSELIWK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024453">
        <property type="entry name" value="Peptidase_C92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05708">
        <property type="entry name" value="Peptidase_C92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220975" evidence="1">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="202" mass="23143" checksum="CD45A511346E5F9E" modified="2005-12-06" version="1">MKIRLLILSLLVSVPAFAWQPQTGDIIFQISRSSQSKAIQLATHSDYSHTGMLVMRNKKPYVFEAVGPVKYTPLKQWIAHGEKGKYVVRRVEGGLSVEQQQKLAQTAKRYLGKPYDFSFSWSDDRQYCSEVVWKVYQNALGMRVGEQQKLKEFDLSSPQVQAKLKERYGKNIPLEETVVSPQAVFDAPQLTTVAKEWPLFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AF3</accession>
    <name>Q32AF3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">secE</name>
        <name evidence="8" type="ordered locus">SDY_3747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001275701.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405193.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AF3"/>
    <dbReference type="STRING" id="300267.SDY_3747"/>
    <dbReference type="EnsemblBacteria" id="ABB63702">
        <property type="protein sequence ID" value="ABB63702"/>
        <property type="gene ID" value="SDY_3747"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3747"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4442"/>
    <dbReference type="HOGENOM" id="CLU_113663_0_1_6"/>
    <dbReference type="OMA" id="FLWLTDK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01650">
        <property type="entry name" value="SECETRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="127" mass="13580" checksum="94D3700A54E875CE" modified="2005-12-06" version="1">MSANTEAQGSGRGLEAMKWVVVVALLLVAIVGNYLYRDIMLPLRALAVVILIAAAGGVALLTTKGKATVAFAREARTEVRKVIWPTRQETLHTTLIVAAVTAVMSLILWGLDGILVPLVSFIPGLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AQ6</accession>
    <name>Q32AQ6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACPS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhhU</name>
        <name evidence="3" type="ordered locus">SDY_3630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000285785.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405090.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AQ6"/>
    <dbReference type="STRING" id="300267.SDY_3630"/>
    <dbReference type="EnsemblBacteria" id="ABB63599">
        <property type="protein sequence ID" value="ABB63599"/>
        <property type="gene ID" value="SDY_3630"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3630"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4309"/>
    <dbReference type="HOGENOM" id="CLU_119926_0_0_6"/>
    <dbReference type="OMA" id="WQIVSID"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="88"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="195" mass="21737" checksum="360557D9C30B2AB7" modified="2005-12-06" version="1">MYRIVLGKVSTLSAAPLPPGLREQAPQGPRRERWLAGRALLSHTLSPLPEIIYGEQGKPAFAPETPLWFNLSHSGDDIALLLSDEGEVGCDIEVIRPRANWRWLANAVFSLGEHAEMDAVHPDQQLEMFWRIWTRKEAIVKQRGGSAWQIVSVDSTYHSSLSVSHCQLENLSLAICTPTPFTLTADSVQWINSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AS3</accession>
    <name>Q32AS3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High-affinity amino acid transport system periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livJ</name>
        <name evidence="5" type="ordered locus">SDY_3611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405073.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AS3"/>
    <dbReference type="STRING" id="300267.SDY_3611"/>
    <dbReference type="EnsemblBacteria" id="ABB63582">
        <property type="protein sequence ID" value="ABB63582"/>
        <property type="gene ID" value="SDY_3611"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3611"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4287"/>
    <dbReference type="HOGENOM" id="CLU_027128_6_0_6"/>
    <dbReference type="OMA" id="MEFTGAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220615" evidence="3">
        <location>
            <begin position="43"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="45"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="386" mass="41342" checksum="B57A24E51875F3D3" modified="2005-12-06" version="1">MLNNNITTHVITRRMGILRMNIKGKALLAGCIALAFSNMALAEDIKVAVVGAMSGPVAQYGDQEFTGAEQAVADINAKGGIKGNKLQIVKYDDACDPKQAVAVANKVVNDGIKYVIGHLCSSSTQPASDIYEDEGILMITPAATAPELTARGYQLILRTTGLDSDQGPMAAKYILEKVKPQRIAIVHDKQQYGEGLARAVQDGLKKGNANVVFFDGITAGEKDFSTLVARLKKENIDFVYYGGYHPEMGQILRQARAAGLKTQFMGPEGVANVSLSNIAGESAEGLLVTKPKNYDQVPANKPIVDAIKAKKQDPSGAFVWTTYAALQSLQAGLNQSDDPAEIAKYLKANSVDTVMGPLTWDEKGDLKGFEFGVFDWHANGTATDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AU3</accession>
    <name>Q32AU3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gntK</name>
        <name evidence="10" type="ordered locus">SDY_3588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AU3"/>
    <dbReference type="SMR" id="Q32AU3"/>
    <dbReference type="STRING" id="300267.SDY_3588"/>
    <dbReference type="EnsemblBacteria" id="ABB63562">
        <property type="protein sequence ID" value="ABB63562"/>
        <property type="gene ID" value="SDY_3588"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3588"/>
    <dbReference type="HOGENOM" id="CLU_077168_1_0_6"/>
    <dbReference type="OMA" id="IQHIWVV"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="162" mass="17994" checksum="2D9931787BB96958" modified="2005-12-06" version="1">MGVSGSGKSAVASEVAHQLHAAFLDGDFLHPRRNIEKMASGEPLNDDDRKPWLQALNDAAFAMQRTNKVSLIVCSALKKHYRDLLREGNPNLSFIYLKGDFDVIESRLKARKGHFFKTQMLVTQFETLQEPGADETDVLVVDIDQPLEGVVASTIEVIKKGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AV3</accession>
    <name>GLGB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="1">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycogen branching enzyme</fullName>
            <shortName evidence="1">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgB</name>
        <name type="ordered locus">SDY_3578</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001283710.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405043.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AV3"/>
    <dbReference type="SMR" id="Q32AV3"/>
    <dbReference type="STRING" id="300267.SDY_3578"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63552">
        <property type="protein sequence ID" value="ABB63552"/>
        <property type="gene ID" value="SDY_3578"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3578"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4249"/>
    <dbReference type="HOGENOM" id="CLU_004245_3_2_6"/>
    <dbReference type="OMA" id="FGMKWMM"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0321">Glycogen metabolism</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000260702" description="1,4-alpha-glucan branching enzyme GlgB">
        <location>
            <begin position="1"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <sequence length="728" mass="84320" checksum="F75BDD17EE19BA14" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B64</accession>
    <name>Q32B64_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted Rossmann-fold nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smf</name>
        <name evidence="3" type="ordered locus">SDY_3462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000228567.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404932.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B64"/>
    <dbReference type="STRING" id="300267.SDY_3462"/>
    <dbReference type="EnsemblBacteria" id="ABB63441">
        <property type="protein sequence ID" value="ABB63441"/>
        <property type="gene ID" value="SDY_3462"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3462"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4115"/>
    <dbReference type="HOGENOM" id="CLU_029601_1_1_6"/>
    <dbReference type="OMA" id="SEMPFGW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="312"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="374" mass="41022" checksum="2B1628FBF6298895" modified="2005-12-06" version="1">MVDTEIWLRLMSVSSLYGDDMVRIAHWLAKQSHIDAVVLQQTGLTLRQAQRFLSFPRKSIESSLCWLEQPNHHLIPADSEFYPPQLLATTDYPGALFVEGELHALHSFQLAVVGSRAHSWYGERWGRLFCETLAKRGVTITSGLARGIDGVAHKAALQVNGVSIAVLGNGLNTIHPRRHARLATSLLEHGGALVSEFPLDVPPLAYNFPRRNRIISGLSKGVLVVEAALRSGSLVTARCALEQGREVFALPGPLGNPGSEGPHWLIKQGAILVTEPEEILENLQFGLHWLPDAPENSFYSPDQEDVALPFPELLANVGDEVTPVDVVAERAGQPVPEVVTQLLELELAGWIAAVPGGYVRLRRACHVRRTNVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BA7</accession>
    <name>Q32BA7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein ZapE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Z ring-associated protein ZapE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yhcM</name>
        <name evidence="3" type="synonym">zapE</name>
        <name evidence="4" type="ordered locus">SDY_3408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Reduces the stability of FtsZ polymers in the presence of ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AFG1 ATPase family. ZapE subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001192327.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404889.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BA7"/>
    <dbReference type="STRING" id="300267.SDY_3408"/>
    <dbReference type="EnsemblBacteria" id="ABB63398">
        <property type="protein sequence ID" value="ABB63398"/>
        <property type="gene ID" value="SDY_3408"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3408"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4066"/>
    <dbReference type="HOGENOM" id="CLU_008681_0_4_6"/>
    <dbReference type="OMA" id="QKREYWE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01919">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030870">
        <property type="entry name" value="ZapE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="PTHR12169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="375" mass="43090" checksum="2F5F6D51E279553C" modified="2005-12-06" version="1">MQSVTPTSQYLKALNEGSHQPDDVQKEAVSRLEIIYQELINSTPPAPRTSGLMARVGKLWGKREDTKHTPVRGLYMWGGVGRGKTWLMDLFYQSLPGERKQRLHFHRFMLRVHEELTALQGQIDPLEIIADRFKAETDVLCFDEFFVSDITDAMLLGGLMKALFARGITLVATSNIPPDELYRNGLQRARFLPAIDAIKQHCDVMNVDAGVDYRLRTLTQAHLWLSPLHDETRAQMDKLWLALAGGKRENSPTLEINHRPLATMGVENQTLAVSFTTLCVDARSQHDYIALSRLFHTVMLFDVPVMTRLMESEARRFIALVDEFYERHVKLVVSAEVPLYEIYQGERLKFEFQRCLSRLQEMQSEEYLKREHLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BC4</accession>
    <name>Q32BC4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhbL</name>
        <name evidence="2" type="ordered locus">SDY_3390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glyoxal + H2O = glycolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:34779"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404872.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BC4"/>
    <dbReference type="STRING" id="300267.SDY_3390"/>
    <dbReference type="EnsemblBacteria" id="ABB63381">
        <property type="protein sequence ID" value="ABB63381"/>
        <property type="gene ID" value="SDY_3390"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3390"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4044"/>
    <dbReference type="HOGENOM" id="CLU_072952_1_0_6"/>
    <dbReference type="OMA" id="AQVQCFA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026041">
        <property type="entry name" value="ElbB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224:SF12">
        <property type="entry name" value="PTHR10224:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006320">
        <property type="entry name" value="Elb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="220" mass="23382" checksum="894B81467075791B" modified="2005-12-06" version="1">MITMKKIGVILSGCGVYDGSEIHEAVLTLLAISRSGAQAVCFAPDKQQVDVINHLTGEAMTETRNVLIEAARITRGEIRPLAQADVAELDALIVPGGFGAAKNLSNFASLGSQCTVDRELKVLAQAMHQAGKPLGFMCIAPAMLPKIFDFPLRLTIGTDIDTAEVLEEMGAEHVPCPVDDIVVDEDNKIVTTPAYMLAQNIAEAASGIDKLVSRVLVLAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BN8</accession>
    <name>RLMG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.174</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2G1835 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (guanine-N(2)-)-methyltransferase RlmG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmG</name>
        <name type="ordered locus">SDY_3267</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10218"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.174"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RlmG family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63267" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.1.1.174" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63267.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000018683.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404758.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BN8"/>
    <dbReference type="SMR" id="Q32BN8"/>
    <dbReference type="STRING" id="300267.SDY_3267"/>
    <dbReference type="PRIDE" id="Q32BN8"/>
    <dbReference type="EnsemblBacteria" id="ABB63267">
        <property type="protein sequence ID" value="ABB63267"/>
        <property type="gene ID" value="SDY_3267"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3267"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3907"/>
    <dbReference type="HOGENOM" id="CLU_040288_4_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052916">
        <property type="term" value="F:23S rRNA (guanine(1835)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01859">
        <property type="entry name" value="23SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017237">
        <property type="entry name" value="rRNA_m2G-MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47816:SF5">
        <property type="entry name" value="PTHR47816:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037565">
        <property type="entry name" value="RRNA_m2G_Mtase_RsmD_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000366523" description="Ribosomal RNA large subunit methyltransferase G">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="378" mass="42300" checksum="6F79DDBA969B4BD8" modified="2009-03-24" version="2">MSHLDNGFRSLTLQRFPATDDVNPLQAWEAADEYLLQQLDDTEIRGPVLILNDAFGALSCALAEHKPYSIGDSYISELATRENLRLNGIDESSVKFLDSTADYPQQPGVVLIKVPKTLALLEQQLRALRKVVTSDTRIIAGAKARDIHTSTLELFEKVLGPTTTTLAWKKARLINCTFNEPPLADAPQTVSWKLEGTDWTIHNHANVFSRTGLDIGARFFMQHLPENLEGEIVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNMPEALDRCEFMINNALSGVEPFRFNAVLCNPPFHQQHALTDNVAWEMFHHARRCLKINGELYIVANRHLDYFHKLKKIFGNCTTIATNNKFVVLKAVKLGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BP4</accession>
    <name>Q32BP4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of ebg operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ebgR</name>
        <name evidence="5" type="ordered locus">SDY_3259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000212445.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404752.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BP4"/>
    <dbReference type="STRING" id="300267.SDY_3259"/>
    <dbReference type="EnsemblBacteria" id="ABB63261">
        <property type="protein sequence ID" value="ABB63261"/>
        <property type="gene ID" value="SDY_3259"/>
    </dbReference>
    <dbReference type="GeneID" id="58389421"/>
    <dbReference type="KEGG" id="sdy:SDY_3259"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3894"/>
    <dbReference type="HOGENOM" id="CLU_037628_1_2_6"/>
    <dbReference type="OMA" id="VYTEFMG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="327" mass="36251" checksum="754F77599383BB97" modified="2005-12-06" version="1">MATLKDIAIEAGVSLATVSRVLNDDPTLNVKEETKHRILEIAEKLEYKTSSARKLQTGAVNQHHILAIYSYQQELEINDPYYLAIRHGIETQCEKLAIELTNCYEHNGLPDIKNVTGILIVGKPTPALRAAASALTDNICFIDFHEPGSGYDAVDIDLARISKEIIDFYINQGVNRIGFIGGEDEPGKADIREVAFAEYGRLKQVVREEDIWRGGFSSSSGYELAKQMLAREDYPKALFVASDSIAIGVLRAIHERGLNIPQDISLISVNDIPTARFTFPPLSTVRIHSEMMGSQGVNLVYEKARDGRALPLLVFVPSKLKLRGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BR0</accession>
    <name>Q32BR0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ygiF</name>
        <name evidence="3" type="ordered locus">SDY_3237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000046284.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404736.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BR0"/>
    <dbReference type="STRING" id="300267.SDY_3237"/>
    <dbReference type="EnsemblBacteria" id="ABB63245">
        <property type="protein sequence ID" value="ABB63245"/>
        <property type="gene ID" value="SDY_3237"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3237"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3866"/>
    <dbReference type="HOGENOM" id="CLU_040400_0_1_6"/>
    <dbReference type="OMA" id="MPCDISK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050355">
        <property type="term" value="F:triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039013">
        <property type="entry name" value="YgiF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39569">
        <property type="entry name" value="PTHR39569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51708">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CHAD" evidence="2">
        <location>
            <begin position="218"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="433" mass="48376" checksum="BD3BCF22399E0A40" modified="2005-12-06" version="1">MAQEIELKFIVNHSAVEALRDHLNTLGGEHHDPVQLLNIYYETPDNWLRGHDMGLRIRGENGRYEMTMKVAGRVTGGLHQRPEYNVALSEPTLDLAQLPTEVWPNGELPADLASRVQPLFSTDFYREKWLVAVDGSRIEIALDQGEVKAGEFAEPICELELELLSGDTRAVLKLANQLVSQIGLRQGSLSKAARGYHLAQGNPAREIKPTTILHVAAKADVEQGLEAALELALAQWQYHEELWVRGNDAAKEQVLAAISLVRHTLMLFGGIVPRKASTHLRDLLTQCEATIASAVSAVTAVYSTETAMAKLALTEWLVSKAWQPFLDAKAQGKISDSFKRFADIHLSRHAAELKSVFCQPLGDCYRDQLPRLTRDIDSILLLAGYYDPVVAQAWLENWQGLHHAIATGQRIEIEHFRNEANNQEPFWLHSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BR3</accession>
    <name>Q32BR3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_3234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404733.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BR3"/>
    <dbReference type="STRING" id="300267.SDY_3234"/>
    <dbReference type="EnsemblBacteria" id="ABB63242">
        <property type="protein sequence ID" value="ABB63242"/>
        <property type="gene ID" value="SDY_3234"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3234"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3863"/>
    <dbReference type="HOGENOM" id="CLU_013048_1_0_6"/>
    <dbReference type="OMA" id="MEQQEAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Flot" evidence="5">
        <location>
            <begin position="325"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="305"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="472" mass="51664" checksum="227FD73C25D3E0FB" modified="2005-12-06" version="1">MEASPTIDSLITKDRMRVDVVVAFFVRVKPSVEGIATAAQTLGQRTLSPEDLRMLVEDKFVDALRATAAQMTMHELQDTRENFVQGVQNTVAEDLSKNGLELESVSLTNFNQTSKEHFNPNNAFDAEGLTKLTQETERRRRERNEVEQDVEVAVREKNRDALSLKLEIEQQEAFMTLEQEQQVKKQNAKIAAFEAERRREAEQTRILAERQIQETEIDREQAVRSRKVEAEREVRIKEIEQQQVTEIANQTKSIAIAAKSEQQSQAEARANLALAEAVSAQQNVETTRQTAEADRAKQVALIAAAQDAETKAVELTVRAKAEKEAAEMQAAAIVELAEATRKKGLAEAEAQRALNDAINVLSDEQTSLKFKLALLQALPAVIEKSVEPMKSIDGIKIIQVDGLNRGGTAGDASAGSVSGGNLAEQALSAALSYRTQAPLIDSLLNEIGVSGGSLAALTSPLTSTTHVAENVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BT9</accession>
    <name>Q32BT9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqiB</name>
        <name evidence="1" type="ordered locus">SDY_3207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000833389.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404707.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BT9"/>
    <dbReference type="STRING" id="300267.SDY_3207"/>
    <dbReference type="EnsemblBacteria" id="ABB63216">
        <property type="protein sequence ID" value="ABB63216"/>
        <property type="gene ID" value="SDY_3207"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3207"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3832"/>
    <dbReference type="HOGENOM" id="CLU_116657_1_1_6"/>
    <dbReference type="OMA" id="NAAMHQP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009659">
        <property type="entry name" value="DUF1249"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38774">
        <property type="entry name" value="PTHR38774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06853">
        <property type="entry name" value="DUF1249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="140" mass="16560" checksum="4AEAA5394FB922E5" modified="2005-12-06" version="1">MKRYTPDFPEMMRLCEMNFSQLRRLLPRNDAPGETVSYQVANAQYRLTIVESTRYTILVTIEQTAPAISYWSLPSMTVRLYHDAMVAEVCSSQQIFRFKARYDYPNKKLHQRDEKHQINQFLADWLRYCLAHGAMAIPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BV4</accession>
    <name>Q32BV4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">prfB</name>
        <name evidence="7" type="ordered locus">SDY_3191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404692.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BV4"/>
    <dbReference type="STRING" id="300267.SDY_3191"/>
    <dbReference type="EnsemblBacteria" id="ABB63201">
        <property type="protein sequence ID" value="ABB63201"/>
        <property type="gene ID" value="SDY_3191"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3191"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3813"/>
    <dbReference type="HOGENOM" id="CLU_036856_6_1_6"/>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="293" mass="32849" checksum="C280FB88DD37B482" modified="2005-12-06" version="1">MKQGLEDVSGLLELAVEADDEETFNEAVAELDALEEKLAQLEFRRMFSGEYDSADCYLDIQAGSGGTEAQDWASMLERMYLRWAESRGFKTEIIEESEGEVAGIKSVTIKISGDYAYGWLRTETGVHRLVRKSPFDSGGRRHTSFSSAFVYPEVDDDIDIEINPADLRIDVYRASGAGGQHVNRTESAVRITHIPTGIVTQCQNDRSQHKNKDQAMKQMKAKLYELEMQKKNAEKQAMEDNKSDIGWGSQIRSYVLDDSRIKDLRTGVETRNTQAVLDGSLDQFIEASLKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C05</accession>
    <name>Q32C05_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C05"/>
    <dbReference type="EnsemblBacteria" id="ABB63150">
        <property type="protein sequence ID" value="ABB63150"/>
        <property type="gene ID" value="SDY_3136"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3136"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="95" mass="10543" checksum="B0682B30D7598705" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITQFVNTNAINAVVAGRNISRITNNDHLRRIAPGSLSRYALNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C59</accession>
    <name>Q32C59_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable processing element for hydrogenase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hybD</name>
        <name evidence="4" type="ordered locus">SDY_3080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001221956.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404587.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C59"/>
    <dbReference type="STRING" id="300267.SDY_3080"/>
    <dbReference type="MEROPS" id="A31.001"/>
    <dbReference type="EnsemblBacteria" id="ABB63096">
        <property type="protein sequence ID" value="ABB63096"/>
        <property type="gene ID" value="SDY_3080"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3080"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3687"/>
    <dbReference type="HOGENOM" id="CLU_099037_0_0_6"/>
    <dbReference type="OMA" id="RKMSSHQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004419">
        <property type="entry name" value="Pept_A31_hyd_express"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00140">
        <property type="entry name" value="hupD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="164" mass="17772" checksum="7CBD04A6C9D3305E" modified="2005-12-06" version="1">MRILVLGVGNILLTDEAIGVRIVEALEQRYILPDYVEILDGGTAGMELLGDMANRDHLIIADAIVSKKSAPGTMMILRYEEVPALFTNKISPHQLGLADVLSALRFTGEFPKKLTLVGVIPESLEPHIGLTPTVEAMIEPALEQVLAALRESGVEAIPREAIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C60</accession>
    <name>Q32C60_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable large subunit, hydrogenase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hybC</name>
        <name evidence="7" type="ordered locus">SDY_3079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000083075.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404586.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C60"/>
    <dbReference type="STRING" id="300267.SDY_3079"/>
    <dbReference type="EnsemblBacteria" id="ABB63095">
        <property type="protein sequence ID" value="ABB63095"/>
        <property type="gene ID" value="SDY_3079"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3079"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3686"/>
    <dbReference type="HOGENOM" id="CLU_030087_0_0_6"/>
    <dbReference type="OMA" id="AMFRGFE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0533">Nickel</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="567" mass="62521" checksum="38E46EE478DCE7F9" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C71</accession>
    <name>Q32C71_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biopolymer transport protein ExbB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">exbB</name>
        <name evidence="16" type="ordered locus">SDY_3067</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The accessory proteins ExbB and ExbD seem to form a complex with TonB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000527844.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404575.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C71"/>
    <dbReference type="SMR" id="Q32C71"/>
    <dbReference type="STRING" id="300267.SDY_3067"/>
    <dbReference type="EnsemblBacteria" id="ABB63084">
        <property type="protein sequence ID" value="ABB63084"/>
        <property type="gene ID" value="SDY_3067"/>
    </dbReference>
    <dbReference type="GeneID" id="67415048"/>
    <dbReference type="KEGG" id="sdy:SDY_3067"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3672"/>
    <dbReference type="HOGENOM" id="CLU_053325_0_2_6"/>
    <dbReference type="OMA" id="PHMVKVG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014164">
        <property type="entry name" value="TonB_ExbB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02797">
        <property type="entry name" value="exbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="15">
        <location>
            <begin position="97"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB63084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="244" mass="26287" checksum="CEB63893A80BA71F" modified="2005-12-06" version="1">MGNNLMQTDLSVWGMYQHADIVVKCVMIGLILASVVTWAIFFSKSVEFFNQKRRLKREQQLLAEARSLNQANDIAADFGSKSLSLHLLNEAQNELELSEGSDDNEGIKERTSFRLERRVAAVGRQMGRGNGYLATIGAISPFVGLFGTVWGIMNSFIGIAQTQTTNLAVVAPGIAEALLATAIGLVAAIPAVVIYNVFARQIGGFKAMLGDVAAQVLLLQSRDLDLEASAAAHPVRVAQKLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CF4</accession>
    <name>Q32CF4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ygcE</name>
        <name evidence="3" type="ordered locus">SDY_2978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000039732.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404492.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CF4"/>
    <dbReference type="STRING" id="300267.SDY_2978"/>
    <dbReference type="EnsemblBacteria" id="ABB63001">
        <property type="protein sequence ID" value="ABB63001"/>
        <property type="gene ID" value="SDY_2978"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2978"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3574"/>
    <dbReference type="HOGENOM" id="CLU_009281_3_4_6"/>
    <dbReference type="OMA" id="QYETIAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="225"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="492" mass="54112" checksum="2626D7EDEB03B295" modified="2005-12-06" version="1">MSKKYIIGIDGGSQSTKVVMYDLEGNVVCEGKGLLQPMHTPDADTAEHPDDDLWASLCFAGHDLMSQFAGNKEDIVGIGLGSIRCCRALLKADGTPAAPLISWQDARVTRPYKHTNPDVAYVTSFSGYLTHRLTGEFKDNIANYFGQWPVDYKSWAWSEDAAVMEKFNIPRHMLFDVQMPGTVLGQITPQAALATHFPAGLPVVCTTSDKPVEALGAGLLDDETAVISLGTYIALMMNGKALPKDPAAYWPIMSSIPETLLYEGYGIRKGMWTVSWLRDMLGESLIQDAKAQDLSPEDLLNKKASCVPPGCNGLMTVLDWLTNPWEPYKRGIMIGFDSSMDYAWIYRSILESVALTLKNNYDNMCNEMNHFAKHVIITGGGSNSDLFMQIFADVFNLPARRNAINGCASLGAAINTAVGLGLYPDYATAVDKMVRVKDIFIPIESNAKRYDAMNKGIFKDLTKHTDVILKKSYEVMHGELGNADSIQSWSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CK7</accession>
    <name>Q32CK7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable small subunit of hydrogenase-3, iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hycB</name>
        <name evidence="5" type="ordered locus">SDY_2921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001079181.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404439.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CK7"/>
    <dbReference type="STRING" id="300267.SDY_2921"/>
    <dbReference type="EnsemblBacteria" id="ABB62948">
        <property type="protein sequence ID" value="ABB62948"/>
        <property type="gene ID" value="SDY_2921"/>
    </dbReference>
    <dbReference type="GeneID" id="66673407"/>
    <dbReference type="KEGG" id="sdy:SDY_2921"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3509"/>
    <dbReference type="HOGENOM" id="CLU_043374_3_0_6"/>
    <dbReference type="OMA" id="RTCPTKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="203" mass="21887" checksum="94FAFE3504A8B61E" modified="2005-12-06" version="1">MNRFVIADSTLCIGCHTCEAACSETHRQHGLQSMPRLRVMLNEKESAPQLCHHCEDAPCAVVCPVNAITRVDGAVQLNESLCVSCKLCGIACPFGAIEFSGSRPLDIPANANTPKAPPAPPAPARISTLLDWVPGIRAIAVKCDLCSFDEQGPACVRMCPTKALHLVDNTDIARVSKRKRELTFNTDFGDLTLFQQAQSGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CS6</accession>
    <name>Q32CS6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CS6"/>
    <dbReference type="STRING" id="300267.SDY_2840"/>
    <dbReference type="EnsemblBacteria" id="ABB62879">
        <property type="protein sequence ID" value="ABB62879"/>
        <property type="gene ID" value="SDY_2840"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2840"/>
    <dbReference type="HOGENOM" id="CLU_113764_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="101" mass="11074" checksum="C5F1EA17E7206A2E" modified="2005-12-06" version="1">MAQIARENGINDNLLFNWRHQYRKGGLLPSGKNMPALLPVTLTPEPDNKIPAPAQEPEQINTPSDSLCCELVLPAGTLRLKGKLTPALLQILIREIKGSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CT5</accession>
    <name>Q32CT5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yfiQ</name>
        <name evidence="4" type="ordered locus">SDY_2827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000082955.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404361.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CT5"/>
    <dbReference type="STRING" id="300267.SDY_2827"/>
    <dbReference type="EnsemblBacteria" id="ABB62870">
        <property type="protein sequence ID" value="ABB62870"/>
        <property type="gene ID" value="SDY_2827"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2827"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3404"/>
    <dbReference type="HOGENOM" id="CLU_007415_0_2_6"/>
    <dbReference type="OMA" id="SFMSQSG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="487"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="726"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="886" mass="97859" checksum="6333913F1E044FE0" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CY7</accession>
    <name>Q32CY7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CY7"/>
    <dbReference type="EnsemblBacteria" id="ABB62818">
        <property type="protein sequence ID" value="ABB62818"/>
        <property type="gene ID" value="SDY_2775"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2775"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="242" mass="27390" checksum="2CB7D5D69281F99E" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLGVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D08</accession>
    <name>Q32D08_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D08"/>
    <dbReference type="EnsemblBacteria" id="ABB62797">
        <property type="protein sequence ID" value="ABB62797"/>
        <property type="gene ID" value="SDY_2754"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2754"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="DNARCES"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27514" checksum="0C8DBD67018754B5" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPVAFREKYHQMAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-11-25" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D14</accession>
    <name>MLTF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Membrane-bound lytic murein transglycosylase F</fullName>
            <ecNumber evidence="1">4.2.2.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Murein lyase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mltF</name>
        <name type="ordered locus">SDY_2748</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exolytic cleavage of the (1-&gt;4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.</text>
            <dbReference type="EC" id="4.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell outer membrane</location>
            <topology>Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Attached to the inner leaflet of the outer membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62791" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="4.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62791.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000734204.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404282.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D14"/>
    <dbReference type="SMR" id="Q32D14"/>
    <dbReference type="STRING" id="300267.SDY_2748"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62791">
        <property type="protein sequence ID" value="ABB62791"/>
        <property type="gene ID" value="SDY_2748"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2748"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3313"/>
    <dbReference type="HOGENOM" id="CLU_027494_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02016">
        <property type="entry name" value="MltF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023703">
        <property type="entry name" value="MltF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000353984" description="Membrane-bound lytic murein transglycosylase F">
        <location>
            <begin position="22"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Non-LT domain" evidence="1">
        <location>
            <begin position="22"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="LT domain" evidence="1">
        <location>
            <begin position="270"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="518" mass="58500" checksum="68D141F7A211C8A0" modified="2008-11-25" version="2" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D21</accession>
    <name>GLYA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="1">SHMT</shortName>
            <shortName evidence="1">Serine methylase</shortName>
            <ecNumber evidence="1">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyA</name>
        <name type="ordered locus">SDY_2741</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000919174.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404275.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D21"/>
    <dbReference type="SMR" id="Q32D21"/>
    <dbReference type="STRING" id="300267.SDY_2741"/>
    <dbReference type="EnsemblBacteria" id="ABB62784">
        <property type="protein sequence ID" value="ABB62784"/>
        <property type="gene ID" value="SDY_2741"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2741"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3305"/>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_6"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000235022" description="Serine hydroxymethyltransferase">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="355"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="site" description="Plays an important role in substrate specificity" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <sequence length="417" mass="45347" checksum="1F9D208F9C9EFD49" modified="2005-12-06" version="1">MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRAKELFGADYANVQPHSGSQANFTVYTALLEPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDATGHIDYADLEKQAKEHKPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLVAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGSEELYKKLNSAVFPGGQGGPLMHVIAGKAVALKEAMEPEFKTYQQQVAKNAKAMVEVFLERGYKVVSGGTDNHLFLVDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRVGTPAITRRGFKEAEAKELAGWMCDVLDSINDEAVIERIKGKVLDICARYPVYA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D32</accession>
    <name>TRMJ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ</fullName>
            <ecNumber evidence="1">2.1.1.200</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA Cm32/Um32 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">trmJ</name>
        <name type="ordered locus">SDY_2728</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42932"/>
            <dbReference type="Rhea" id="RHEA-COMP:10288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10289"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.200"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42936"/>
            <dbReference type="Rhea" id="RHEA-COMP:10107"/>
            <dbReference type="Rhea" id="RHEA-COMP:10290"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.200"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.200" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000940018.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404264.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D32"/>
    <dbReference type="SMR" id="Q32D32"/>
    <dbReference type="STRING" id="300267.SDY_2728"/>
    <dbReference type="EnsemblBacteria" id="ABB62773">
        <property type="protein sequence ID" value="ABB62773"/>
        <property type="gene ID" value="SDY_2728"/>
    </dbReference>
    <dbReference type="GeneID" id="66673580"/>
    <dbReference type="KEGG" id="sdy:SDY_2728"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3290"/>
    <dbReference type="HOGENOM" id="CLU_056931_0_1_6"/>
    <dbReference type="OMA" id="PIMNLSH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00050">
        <property type="entry name" value="rRNA_methyl_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000313862" description="tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0AE01"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="245" mass="26919" checksum="71AE4507E097D2A4" modified="2005-12-06" version="1">MLQNIRIVLVETSHTGNMGSVARAMKTMGLTNLWLVNPLVKPDSQAIALAAGASDVIGNAHIVDTLDEALAGCSLVVGTSARSRTLPWPMLDPRECGLKSVAEAANTPVALVFGRERVGLTNEELQKCHYHVAIAANPEYSSLNLAMAVQVIAYEVRMAWLATQENGEQVEHEETPYPLVDDLERFYGHLEQTLLATGFIRENHPGQVMNKLRRLFTRARPESQELNILRGILASIEQQNKGNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D88</accession>
    <name>Q32D88_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer membrane protein assembly factor BamC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nlpB</name>
        <name evidence="4" type="synonym">bamC</name>
        <name evidence="5" type="ordered locus">SDY_2666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BamC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404208.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D88"/>
    <dbReference type="STRING" id="300267.SDY_2666"/>
    <dbReference type="EnsemblBacteria" id="ABB62717">
        <property type="protein sequence ID" value="ABB62717"/>
        <property type="gene ID" value="SDY_2666"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2666"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3217"/>
    <dbReference type="HOGENOM" id="CLU_063217_1_0_6"/>
    <dbReference type="OMA" id="YTVVWDR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00924">
        <property type="entry name" value="OM_assembly_BamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014524">
        <property type="entry name" value="BamC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042268">
        <property type="entry name" value="BamC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010653">
        <property type="entry name" value="NlpB/DapX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06804">
        <property type="entry name" value="Lipoprotein_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026343">
        <property type="entry name" value="NlpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="345" mass="36921" checksum="6AE7D3DA4AF35967" modified="2005-12-06" version="1">MMAYSVQKSRLAKVAGVSLVLLLAACSSDSRYKRQVSGDEAYLEAAPLAELHAPAGMILPVTSGDYAIPVTNGSGAVGKALDIRPPAQPLALVSGARTQFTGDTASLLVENGRGNTLWPQVVSVLQAKNYTITQRDDAGQTLTTDWVQWNCLDEDEQYRGRYQISVKPQGYQQAVTVKLLNLEQAGKPVADAASMQRYSTEMMNVISAGLDKSATDAANAAQNRASTTMDVQSAADDTGLPMLVVRGPFNVVWQRLPAALEKVGMKVTDSTRSQGNMAVTYKPLSDSDWQELGASDPGLASGDYKLQVGDLDNRSSLQFIDPKGHTLTQSQNDALVAVFQAAFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DG0</accession>
    <name>Q32DG0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_2584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000173227.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404136.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DG0"/>
    <dbReference type="STRING" id="300267.SDY_2584"/>
    <dbReference type="MEROPS" id="M24.008"/>
    <dbReference type="EnsemblBacteria" id="ABB62645">
        <property type="protein sequence ID" value="ABB62645"/>
        <property type="gene ID" value="SDY_2584"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2584"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3118"/>
    <dbReference type="HOGENOM" id="CLU_017266_4_0_6"/>
    <dbReference type="OMA" id="YCSDRTR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="3">
        <location>
            <begin position="84"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="304" mass="33254" checksum="725D13BE24D31E04" modified="2005-12-06" version="1">MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVLISRESAHILVDSRYYADVEARTQGYQLHLLDATHTLTTIGRQIIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGDGVSAESHPLFNVYQIVLQAQLAAISAIRPGVRCQQVDEAARRVITEAGFSHYFGHNTGHAIGIEVHEDPRFSPRDTTTLQPGMLLTVEPGIYLLGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DK4</accession>
    <name>Q32DK4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fimbrial-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001022644.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404092.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DK4"/>
    <dbReference type="STRING" id="300267.SDY_2532"/>
    <dbReference type="EnsemblBacteria" id="ABB62601">
        <property type="protein sequence ID" value="ABB62601"/>
        <property type="gene ID" value="SDY_2532"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2532"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3048"/>
    <dbReference type="HOGENOM" id="CLU_088965_3_3_6"/>
    <dbReference type="OMA" id="IGMETTD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000259">
        <property type="entry name" value="Adhesion_dom_fimbrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00419">
        <property type="entry name" value="Fimbrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221065" evidence="1">
        <location>
            <begin position="28"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Fimbrial" evidence="2">
        <location>
            <begin position="37"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="179" mass="19260" checksum="D9A83A238EBFD60A" modified="2005-12-06" version="1">MNIKSLHSMKYALPVALMFAISWPSFAGDNNLHFTGHLLSKSCTLVVNGGLLAEVHFPVVSNRDLMVAGQSSRVPVVFQLKDCKGPSNYEVKVTLTGTEDSEQAGYLALDTSSAAQGVSIGMEKTDGTWVAINNTAGTTFTLNNGDNNINFNAWLQAKSGREVTLGEFTATMTATFEYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DK9</accession>
    <name>MEPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Penicillin-insensitive murein endopeptidase</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-alanyl-D-alanine-endopeptidase</fullName>
            <shortName evidence="1">DD-endopeptidase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mepA</name>
        <name type="ordered locus">SDY_2527</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. Zn(2+) ion 1 is bound in the active site. Zn(2+) ion 2 is bound at the dimer interface by residues from both subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M74 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001043835.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404087.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DK9"/>
    <dbReference type="SMR" id="Q32DK9"/>
    <dbReference type="STRING" id="300267.SDY_2527"/>
    <dbReference type="MEROPS" id="M74.001"/>
    <dbReference type="EnsemblBacteria" id="ABB62596">
        <property type="protein sequence ID" value="ABB62596"/>
        <property type="gene ID" value="SDY_2527"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2527"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3043"/>
    <dbReference type="HOGENOM" id="CLU_052496_0_0_6"/>
    <dbReference type="OMA" id="VRPWWGH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01623">
        <property type="entry name" value="MepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005073">
        <property type="entry name" value="Peptidase_M74"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03411">
        <property type="entry name" value="Peptidase_M74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018455">
        <property type="entry name" value="MepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000292557" description="Penicillin-insensitive murein endopeptidase">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="44"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="187"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="216"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="274" mass="30175" checksum="EF91A870104E3301" modified="2005-12-06" version="1" precursor="true">MNKTAIALLALLASSVSLAATPWQKITQPVPGSAQSIGSFSNGCIVGADTLPIQSEHYQVMRTDQRRYFGHPDLVMFIQRLSSQVSNLGMGTVLIGDMGMPAGGRFNGGHASHQTGLDVDIFLQLPKTRWTSAQLLRPQALDLVSRDGKHVVSTLWKPEIFSLIKLAAQDKDVTRIFVNPAIKQQLCLDAGTDRDWLRKVRPWFQHRAHMHVRLRCPADSLECEDQPLPPPGDGCGAELQSWFEPPKPGTTKPEKKTPPPLPPSCQALLDEHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DQ9</accession>
    <name>Q32DQ9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="3">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nuoJ</name>
        <name evidence="4" type="ordered locus">SDY_2476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000393511.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404037.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DQ9"/>
    <dbReference type="SMR" id="Q32DQ9"/>
    <dbReference type="STRING" id="300267.SDY_2476"/>
    <dbReference type="EnsemblBacteria" id="ABB62546">
        <property type="protein sequence ID" value="ABB62546"/>
        <property type="gene ID" value="SDY_2476"/>
    </dbReference>
    <dbReference type="GeneID" id="66673837"/>
    <dbReference type="KEGG" id="sdy:SDY_2476"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2987"/>
    <dbReference type="HOGENOM" id="CLU_085957_0_1_6"/>
    <dbReference type="OMA" id="WVLPFEA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="184" mass="19875" checksum="9C9D0C9ABAEC7755" modified="2005-12-06" version="1">MEFAFYICGLIAILATLRVITHTNPVHALLYLIISLLAISGVFFSLGAYFAGALEIIVYAGAIMVLFVFVVMMLNLGGSEIEQERQWLKPQVWIGPAILSAIMLVVIVYAILGVNDQGIDGTPISAKAVGITLFGPYVLAVELASMLLLAGLVVAFHVGREERAGEVLSNRKDDSAKRKTEEHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DS5</accession>
    <name>MENH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase</fullName>
            <shortName evidence="1">SHCHC synthase</shortName>
            <ecNumber evidence="1">4.2.99.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">menH</name>
        <name type="ordered locus">SDY_2459</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:25597"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="4.2.99.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MenH family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000600553.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404021.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DS5"/>
    <dbReference type="SMR" id="Q32DS5"/>
    <dbReference type="STRING" id="300267.SDY_2459"/>
    <dbReference type="ESTHER" id="shifl-YFBB">
        <property type="family name" value="MenH_SHCHC"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62530">
        <property type="protein sequence ID" value="ABB62530"/>
        <property type="gene ID" value="SDY_2459"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2459"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2966"/>
    <dbReference type="HOGENOM" id="CLU_020336_38_2_6"/>
    <dbReference type="OMA" id="LNDWYQQ"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070205">
        <property type="term" value="F:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01660">
        <property type="entry name" value="MenH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022485">
        <property type="entry name" value="SHCHC_synthase_MenH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03695">
        <property type="entry name" value="menH_SHCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000341925" description="2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01660"/>
        </source>
    </evidence>
    <sequence length="252" mass="27755" checksum="AE0DEE7E71E6E82A" modified="2005-12-06" version="1">MILHAQTKHGKPGLPWLVFLHGFSGDCHEWQEVGEVFADYSRLYVDLPGHGGSAAISVDGFDDVTDLLRKTLVSYNILDFWLVGYSLGGRVAMMAACQGLAGLCGVIVEGGHPGLQNAEQRAERQRSDRQWAQRFRTEPLTAVFADWYQQPVFASLNDDQRRELVALRSNNNGATLAAMLEATSLAVQPDLRANLSARTFAFYYLCGERDSKFRALAAELAADCHVIPRAGHNAHRENPAGVIASLAQILRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E38</accession>
    <name>KDSB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-deoxy-manno-octulosonate cytidylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">CMP-2-keto-3-deoxyoctulosonic acid synthase</fullName>
            <shortName evidence="1">CKS</shortName>
            <shortName evidence="1">CMP-KDO synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kdsB</name>
        <name type="ordered locus">SDY_2340</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23448"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.7.7.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KdsB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.38" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000011593.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403908.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E38"/>
    <dbReference type="SMR" id="Q32E38"/>
    <dbReference type="STRING" id="300267.SDY_2340"/>
    <dbReference type="EnsemblBacteria" id="ABB62417">
        <property type="protein sequence ID" value="ABB62417"/>
        <property type="gene ID" value="SDY_2340"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2340"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2824"/>
    <dbReference type="HOGENOM" id="CLU_065038_1_0_6"/>
    <dbReference type="OMA" id="FMATCAK"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00358">
        <property type="reaction ID" value="UER00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008690">
        <property type="term" value="F:3-deoxy-manno-octulosonate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033468">
        <property type="term" value="P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02517">
        <property type="entry name" value="CMP-KDO-Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00057">
        <property type="entry name" value="KdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004528">
        <property type="entry name" value="KdsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00466">
        <property type="entry name" value="kdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000003382" description="3-deoxy-manno-octulosonate cytidylyltransferase">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00057"/>
        </source>
    </evidence>
    <sequence length="248" mass="27610" checksum="DA73BF6F4FF20079" modified="2005-12-06" version="1">MSFVVIIPARYASTRLPGKPLVDINGKPMIVHVLERARESGADRIIVATDHEDVARAVEAAGGEVCMTRADHQSGTERLAEVVEKCAFSDDTVIVNVQGDEPMIPATIIRQVADNLAQRQVGMATLAVPIHNAEEAFNPNAVKVVLDAEGYALYFSRATIPWERDRFAKGLETVGDNFLRHLGIYGYRAGFIRRYVTWQPSPLEHIEMLEQLRVLWYGEKIHVAVAHEVPGTGVDTPEDLERVRAEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EC1</accession>
    <name>Q32EC1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transport protein, shikimate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">shiA</name>
        <name evidence="10" type="ordered locus">SDY_2254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000378541.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403825.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EC1"/>
    <dbReference type="EnsemblBacteria" id="ABB62334">
        <property type="protein sequence ID" value="ABB62334"/>
        <property type="gene ID" value="SDY_2254"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2254"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2722"/>
    <dbReference type="HOGENOM" id="CLU_001265_39_5_6"/>
    <dbReference type="OMA" id="LWIRNGM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004736">
        <property type="entry name" value="MHS_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00883">
        <property type="entry name" value="2A0106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="23"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="438" mass="47835" checksum="BFE1EF4AF23EC73D" modified="2005-12-06" version="1">MDSTLISTRPDEGMLSLSRARRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLDGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHNQAAAKKRIPVIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALITYFAGNWHSVAIYLLAGCLISAITALLMKDNQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EH4</accession>
    <name>Q32EH4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11 12">Uridine kinase</fullName>
            <ecNumber evidence="7 11 12">2.7.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytidine monophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Uridine monophosphokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">udk</name>
        <name evidence="14" type="ordered locus">SDY_2196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + cytidine = ADP + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11 12">
            <text>ATP + uridine = ADP + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 11 12">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11 12">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 11 12">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="7 11 12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EH4"/>
    <dbReference type="STRING" id="300267.SDY_2196"/>
    <dbReference type="EnsemblBacteria" id="ABB62281">
        <property type="protein sequence ID" value="ABB62281"/>
        <property type="gene ID" value="SDY_2196"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2196"/>
    <dbReference type="HOGENOM" id="CLU_021278_1_2_6"/>
    <dbReference type="OMA" id="TTLKPMH"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00551">
        <property type="entry name" value="Uridine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026008">
        <property type="entry name" value="Uridine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="13">
        <location>
            <begin position="28"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB62281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="231" mass="26447" checksum="B4470209386338E4" modified="2005-12-06" version="1">MALRRPLPNIQVNQVAKYMTDQSHQCVIIGIAGASASGKSLIASTLYRELREQVGDEHIGVIPEDCYYKDQSHLSMEERVKTNYDHPSAMDHSLLLEHLQALKRGSAIDLPVYSYVEHTRMKETVTVEPKKVIILEGILLLTDARLRDELNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EI0</accession>
    <name>Q32EI0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISSfl2 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021650.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403766.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EI0"/>
    <dbReference type="STRING" id="300267.SDY_2189"/>
    <dbReference type="EnsemblBacteria" id="ABB62275">
        <property type="protein sequence ID" value="ABB62275"/>
        <property type="gene ID" value="SDY_2189"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2189"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2647"/>
    <dbReference type="HOGENOM" id="CLU_036902_2_3_6"/>
    <dbReference type="OMA" id="MSRIWAG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="14"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="398" mass="43026" checksum="A5A43AB4862BCB26" modified="2005-12-06" version="1">MTESSDYESVQVFIGVDVGKDTHHAVAINRSGKRLFDKALPNDENKLRSLISDLKQHGQILLVVDQPATIGALPVAVARSEGVLVGYLPGLAMRRIADLHAGEAKTDARDAAIIAEAARTLPHALRTLKLADEQIAELSMLCGFDDDLAAQTTQASNRIRGLLTQIHPALELVLGPRLELPAVLDLLQRYPSPEKLASLGEKKLAAQLCKLAPRLGKRLAADIAQALAEQTVVVPGTNAAAVVLPRLALQLITLRKQRDEVALEVEQRVLAHPLYPVLTSMPGAGVRTAARLPTEVACRAFASAAHLAAYAGLAPVTRRSGSSIRGEHPSRRGNKALKRALFLSAFAALRDPLSRAYYTRKMSQGKRHNQALIALARRRCDVLFAMMRDGTFYTPQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EI9</accession>
    <name>Q32EI9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403757.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EI9"/>
    <dbReference type="STRING" id="300267.SDY_2180"/>
    <dbReference type="EnsemblBacteria" id="ABB62266">
        <property type="protein sequence ID" value="ABB62266"/>
        <property type="gene ID" value="SDY_2180"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2180"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2635"/>
    <dbReference type="HOGENOM" id="CLU_006807_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="362" mass="41143" checksum="142C86DFDA57B180" modified="2005-12-06" version="1">MHIPPITKATPEVETSPESKNQRPWLADDAVIRLTDDINRFAFPHRSRPREINYLHKDGQIWQRIANNTRAYDPDNNYRSYPENWQQAFAELQMQVKGNQPTGSAQSDAALLWGFWNSYSQDELVDDLVIRCGLESAVEIALLALQLKYKPVKGAVTTIIPPNHEAESLPSWHQRLCHHLSLASEDEWQRCVDKVLAAIPTLSPARQPFAALLIPERPDIANAMALRYADHNVPAMTWLRLVVTDDAALTTAEKYDFPPLYHDFRAYLAMLLANNGVRGVSRILLEFTEEHSDNPTYLFERISETEDLVKWLWKTNHPDAIQILILGVIGKKKRLEYLSKACQKHPAAALAAYATLLAIHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ES5</accession>
    <name>Q32ES5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">grxB</name>
        <name evidence="2" type="ordered locus">SDY_2089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000780928.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403671.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ES5"/>
    <dbReference type="STRING" id="300267.SDY_2089"/>
    <dbReference type="EnsemblBacteria" id="ABB62180">
        <property type="protein sequence ID" value="ABB62180"/>
        <property type="gene ID" value="SDY_2089"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2089"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2514"/>
    <dbReference type="HOGENOM" id="CLU_072939_0_1_6"/>
    <dbReference type="OMA" id="GKKMAPI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03199">
        <property type="entry name" value="GST_C_GRX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007494">
        <property type="entry name" value="Glutaredoxin2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011901">
        <property type="entry name" value="Grx2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04399">
        <property type="entry name" value="Glutaredoxin2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01204">
        <property type="entry name" value="Grx2-like.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02182">
        <property type="entry name" value="GRXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="215" mass="24374" checksum="737810C1A5A6FFEC" modified="2005-12-06" version="1">MKLYIYDHCPYCLKVRMIFGLKNIPVELHVLLNDDAETPTRMVGQKQVPILQKDDSRYMPESMDIVHYVDKLDGKPLLTGKRSPAIEEWLRKVNGYANKLLLPRFAKSAFDEFSTPAARKYFVDKKEASAGNFADLLAHSDGLIKNISDDLRALDKLIVKPNAVNGELSEDDIQLFPLLRNLPLVAGINWPSRVADYRDNMAKQTQINLLSSMAI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ET9</accession>
    <name>FLGH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellar L-ring protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Basal body L-ring protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">flgH</name>
        <name type="ordered locus">SDY_2072</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378771.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403657.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ET9"/>
    <dbReference type="SMR" id="Q32ET9"/>
    <dbReference type="STRING" id="300267.SDY_2072"/>
    <dbReference type="EnsemblBacteria" id="ABB62166">
        <property type="protein sequence ID" value="ABB62166"/>
        <property type="gene ID" value="SDY_2072"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2072"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2488"/>
    <dbReference type="HOGENOM" id="CLU_069313_0_0_6"/>
    <dbReference type="OMA" id="ITQQPMT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009427">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, L ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00415">
        <property type="entry name" value="FlgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000527">
        <property type="entry name" value="Flag_Lring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34933">
        <property type="entry name" value="PTHR34933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02107">
        <property type="entry name" value="FlgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01008">
        <property type="entry name" value="FLGLRINGFLGH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000236835" description="Flagellar L-ring protein">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00415"/>
        </source>
    </evidence>
    <sequence length="232" mass="24632" checksum="FA6E5770322F73FB" modified="2005-12-06" version="1" precursor="true">MQKNAAHTYAISSLLVLSLTGCAWIPSTPLVQGATSAQPVLGPTPVANGSIFQSAQPINYGYQPLFEDRRPRNIGDTLTIVLQENVSASKSSSANASRDGKTNFGFDTVPRYLQGLFGNARADVEASGGNTFNGKGGANASNTFSGTLTVTVDQVLVNGNLHVVGEKQIAINQGTEFIRFSGVVNPRTISGSNTVPSTQVADARIEYVGNGYINEAQNMGWLQRFFLNLSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EU3</accession>
    <name>Q32EU3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease E</fullName>
            <shortName evidence="6">RNase E</shortName>
            <ecNumber evidence="6">3.1.26.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rne</name>
        <name evidence="9" type="ordered locus">SDY_2067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.</text>
            <dbReference type="EC" id="3.1.26.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per homotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNase E/G family. RNase E subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase E/G family. RNase G subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.12" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000827432.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403653.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EU3"/>
    <dbReference type="STRING" id="300267.SDY_2067"/>
    <dbReference type="EnsemblBacteria" id="ABB62162">
        <property type="protein sequence ID" value="ABB62162"/>
        <property type="gene ID" value="SDY_2067"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2067"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2482"/>
    <dbReference type="HOGENOM" id="CLU_003468_1_2_6"/>
    <dbReference type="OMA" id="SDWVRPA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008995">
        <property type="term" value="F:ribonuclease E activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00970">
        <property type="entry name" value="RNase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021968">
        <property type="entry name" value="PNPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028878">
        <property type="entry name" value="RNase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12111">
        <property type="entry name" value="PNPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for zinc-mediated homotetramerization and catalytic activity" evidence="6">
        <location>
            <begin position="404"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="585"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="774"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="592"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="657"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="783"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1061" mass="118418" checksum="5607232CC043E60D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EX1</accession>
    <name>Q32EX1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycfQ</name>
        <name evidence="3" type="ordered locus">SDY_2039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403625.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EX1"/>
    <dbReference type="STRING" id="300267.SDY_2039"/>
    <dbReference type="EnsemblBacteria" id="ABB62134">
        <property type="protein sequence ID" value="ABB62134"/>
        <property type="gene ID" value="SDY_2039"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2039"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2453"/>
    <dbReference type="HOGENOM" id="CLU_069356_28_0_6"/>
    <dbReference type="OMA" id="MAVQATN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="236" mass="26208" checksum="D84D85BF064B9642" modified="2005-12-06" version="1">MGSGLVNGGDYFYNNLSFTVTRYNGIMATDSTQCVKKSRGRPKVFDRDAALDKAMKLFWQHGYEATSLADLVEATGAKAPTLYAEFTNKEGLFRAVLDRYIDRFAAKHEAQLFCEEKSVESALADYFAAIANCFTSKDTPAGCFMINNCTTLSPDSGDIANTLKSRHAMQERTLQQFLCQRQARGEIPTHCDVTHLAEFLNCIIQGMSISAREGASLEKLMQIAGTTLRLWPELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F62</accession>
    <name>Q32F62_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phage shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pspC</name>
        <name evidence="8" type="ordered locus">SDY_1938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000907387.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403534.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F62"/>
    <dbReference type="SMR" id="Q32F62"/>
    <dbReference type="STRING" id="300267.SDY_1938"/>
    <dbReference type="EnsemblBacteria" id="ABB62043">
        <property type="protein sequence ID" value="ABB62043"/>
        <property type="gene ID" value="SDY_1938"/>
    </dbReference>
    <dbReference type="GeneID" id="66674866"/>
    <dbReference type="KEGG" id="sdy:SDY_1938"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2337"/>
    <dbReference type="HOGENOM" id="CLU_137949_2_0_6"/>
    <dbReference type="OMA" id="MEAYVTS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014320">
        <property type="entry name" value="Phageshock_PspC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02978">
        <property type="entry name" value="phageshock_pspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13517" checksum="F63BED3EC5EDEE90" modified="2005-12-06" version="1">MAGINLNKKLWRIPQQGMVRGVCAGIANYFDVPVKLVRILVVLSIFFGLALFTLVAYIILSFALDPMPDNMAFGEQLPSSSELLDEVDRELAASETRLREMERYVTSDTFTLRSRFRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FA9</accession>
    <name>Q32FA9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ribE</name>
        <name evidence="10" type="ordered locus">SDY_1888</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin</text>
            <dbReference type="Rhea" id="RHEA:20772"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="EC" id="2.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000493947.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403487.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FA9"/>
    <dbReference type="SMR" id="Q32FA9"/>
    <dbReference type="STRING" id="300267.SDY_1888"/>
    <dbReference type="EnsemblBacteria" id="ABB61996">
        <property type="protein sequence ID" value="ABB61996"/>
        <property type="gene ID" value="SDY_1888"/>
    </dbReference>
    <dbReference type="GeneID" id="66674445"/>
    <dbReference type="KEGG" id="sdy:SDY_1888"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2271"/>
    <dbReference type="HOGENOM" id="CLU_034388_0_1_6"/>
    <dbReference type="OMA" id="HILSGHV"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="8">
        <location>
            <begin position="98"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="98"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="213" mass="23445" checksum="CD1C7E40E4AC88B6" modified="2005-12-06" version="1">MFTGIVQGTAKLVSIDEKPNFRTHVVELPDHMLDGLETGASVAHNGCCLTVTEINGNHVSFDLMKETLRITNLGDLKVGDWVNVERAAKFSDEIGGHLMSGHIMTTAEVAKILTSENNRQIWFKVQDSQLMKYILYKGFIGIDGISLTVGEVTPTRFCVHLIPETLERTTLGKKKLGARVNIEIDPQTQAVVDTVERVLAARENAMNQPGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FQ6</accession>
    <name>Q32FQ6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SDY_1729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GhoT/OrtT toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FQ6"/>
    <dbReference type="STRING" id="300267.SDY_1729"/>
    <dbReference type="EnsemblBacteria" id="ABB61849">
        <property type="protein sequence ID" value="ABB61849"/>
        <property type="gene ID" value="SDY_1729"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1729"/>
    <dbReference type="HOGENOM" id="CLU_189012_0_0_6"/>
    <dbReference type="OMA" id="FTFFMSK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019689">
        <property type="entry name" value="Toxin_GhoT/OrtT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10753">
        <property type="entry name" value="Toxin_GhoT_OrtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="9614" checksum="587E8BBCD84F6D15" modified="2005-12-06" version="1">MKKLDARQKMTHICARFIHLAGRPYMSLYQHMLVFYAVMAAIAFLITWFLSHDKKRIRFLSAFLVGATWPMSFPVALLFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G02</accession>
    <name>Q32G02_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
            <ecNumber evidence="2">2.7.7.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24898"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="2.7.7.65"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022666.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403244.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G02"/>
    <dbReference type="STRING" id="300267.SDY_1629"/>
    <dbReference type="EnsemblBacteria" id="ABB61753">
        <property type="protein sequence ID" value="ABB61753"/>
        <property type="gene ID" value="SDY_1629"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1629"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1962"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_27_6"/>
    <dbReference type="OMA" id="WFEQSLR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="330"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="499" mass="55631" checksum="88697BF685515FAB" modified="2005-12-06" version="1">MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFARYVWLNRLHYYAISYVAMLVYDVITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGRNKYEPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTALCVTVRKLSDIFIHSERFKCNVFYHFMFEEKSYFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G33</accession>
    <name>Q32G33_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydeF</name>
        <name evidence="8" type="ordered locus">SDY_1593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001054206.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403213.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G33"/>
    <dbReference type="STRING" id="300267.SDY_1593"/>
    <dbReference type="EnsemblBacteria" id="ABB61722">
        <property type="protein sequence ID" value="ABB61722"/>
        <property type="gene ID" value="SDY_1593"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1593"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1914"/>
    <dbReference type="HOGENOM" id="CLU_001265_60_0_6"/>
    <dbReference type="OMA" id="WESNLSV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="8"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="395" mass="42613" checksum="476C2545F2B90608" modified="2005-12-06" version="1">MNLSLRRSTSALLASSLLLTIGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFTSGFIAIPLVNNVTLVVLFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQSINLPFWLAAICSAFPMLFIQIWVKRSEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIADGDFAEKVVAVVLPVNAAMVVTLQYSVGRRLNPANIRALMTAGTLCFVIGLIGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSAQSLGWLGAAINPLVSGVVLTSLPPSSLFIILALVIIAAWVLMLKGIRAKPWGQPALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G39</accession>
    <name>Q32G39_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dipeptidyl carboxypeptidase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dcp</name>
        <name evidence="9" type="ordered locus">SDY_1587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378718.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403207.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G39"/>
    <dbReference type="STRING" id="300267.SDY_1587"/>
    <dbReference type="MEROPS" id="M03.005"/>
    <dbReference type="EnsemblBacteria" id="ABB61716">
        <property type="protein sequence ID" value="ABB61716"/>
        <property type="gene ID" value="SDY_1587"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1587"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1906"/>
    <dbReference type="HOGENOM" id="CLU_001805_4_0_6"/>
    <dbReference type="OMA" id="YQCMPLD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660">
        <property type="entry name" value="PTHR43660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="8">
        <location>
            <begin position="230"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="681" mass="77442" checksum="57DC5E47CC4C0CD6" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G87</accession>
    <name>ASTB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-succinylarginine dihydrolase</fullName>
            <ecNumber evidence="1">3.5.3.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">astB</name>
        <name type="ordered locus">SDY_1532</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + 2 H2O + N(2)-succinyl-L-arginine = CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19533"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58241"/>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
            <dbReference type="EC" id="3.5.3.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the succinylarginine dihydrolase family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB61668" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.5.3.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61668.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403159.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G87"/>
    <dbReference type="SMR" id="Q32G87"/>
    <dbReference type="STRING" id="300267.SDY_1532"/>
    <dbReference type="EnsemblBacteria" id="ABB61668">
        <property type="protein sequence ID" value="ABB61668"/>
        <property type="gene ID" value="SDY_1532"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1532"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1835"/>
    <dbReference type="HOGENOM" id="CLU_053835_0_0_6"/>
    <dbReference type="UniPathway" id="UPA00185">
        <property type="reaction ID" value="UER00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009015">
        <property type="term" value="F:N-succinylarginine dihydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:arginine catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019545">
        <property type="term" value="P:arginine catabolic process to succinate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01172">
        <property type="entry name" value="AstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037031">
        <property type="entry name" value="AstB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007079">
        <property type="entry name" value="SuccinylArg_d-Hdrlase_AstB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04996">
        <property type="entry name" value="AstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03241">
        <property type="entry name" value="arg_catab_astB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0056">Arginine metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000262378" description="N-succinylarginine dihydrolase">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="448" mass="49589" checksum="E16919C350C64521" modified="2006-11-28" version="2">MRNAWEVNFDGLVGLTHNYAGLLFGNEASTRHRFQVSNPRLAAKQGLLKMKNLADAGFPQAVIPPHERPFIPVLRQLGFSGSDEQVLEKVARQAPHWLSSVSSASPMWVANAATIAPSVDTLDGKVHRTVANLNNKFHRSLEAPVTESLLKAIFNDEEKFSVHSALPQVALLGDEGAANHNRLGGHYGEPGMQLFVYGREKGNDTRPSRYPARQTREASEAVARLNQVNPQQVIFAQQNPDVIDQGVFHNDVIAVSNRQVLFCHQQAFARQSQLLANLRARVNGFMAIEVPATQVSVSDAVSTYLFNSQLLSRDDGSMMLVLPQECREHAGVWCYLNELLAADNPISELKVFDLRESMANGGGPACLRLRVVLTEEERRAVNPAVMMNDTLFNALNDWGDRYYRDRLTDADLADPQLLREGREALDVLSQLLNLGSVYPFQREGGGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GC4</accession>
    <name>Q32GC4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_1492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000435282.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403122.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GC4"/>
    <dbReference type="STRING" id="300267.SDY_1492"/>
    <dbReference type="EnsemblBacteria" id="ABB61631">
        <property type="protein sequence ID" value="ABB61631"/>
        <property type="gene ID" value="SDY_1492"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1492"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1780"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_6"/>
    <dbReference type="OMA" id="AYFTAWL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="24"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="459" mass="49613" checksum="E4B79C404214F53B" modified="2005-12-06" version="1">MEQITKPHCGARLDRLPDCRWHSSMFAIVAFGLLVCWSNAVGGLILAQLKALGWTDNSTTATFSAITTAGMFLGALVGGIIGDKTGRRNAFILYEAIHIASMVVGAFSPNMDFLIACRFVMGVGLGALLVTLFAGFTEYMPGRNRGTWSSRVSFIGNWSYPLCSLIAMGLTPLISAEWNWRVQLLIPAILSLIATALAWRYFPESPRWLESRGRYQEAEKVMRSIEEGVIHQTGKPLPPVVIADDGKTPQAVPYSALLTGVLLKRVILGSCVLIAMNVVQYTLINWLPTIFMTQGINLKDSIVLNTMSMFGAPFGIFIAMLVMDKIPRKTMGVGLLILIAVLGYIYSLQTSMLLITLIGFFLITFVYMYVCYASAVYVPEIWPTEAKLRGSGLANAVGRISGIAAPYAVAVLLSSYGVTGVFILLGAVSIIVAIAIATIGIETKGVSVESLSIDAVANK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GI7</accession>
    <name>ZNTB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc transport protein ZntB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">zntB</name>
        <name type="ordered locus">SDY_1424</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Zinc transporter. Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(out) + Zn(2+)(out) = H(+)(in) + Zn(2+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71195"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:71196"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000387388.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403059.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GI7"/>
    <dbReference type="SMR" id="Q32GI7"/>
    <dbReference type="STRING" id="300267.SDY_1424"/>
    <dbReference type="EnsemblBacteria" id="ABB61568">
        <property type="protein sequence ID" value="ABB61568"/>
        <property type="gene ID" value="SDY_1424"/>
    </dbReference>
    <dbReference type="GeneID" id="66674830"/>
    <dbReference type="KEGG" id="sdy:SDY_1424"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1694"/>
    <dbReference type="HOGENOM" id="CLU_007127_2_0_6"/>
    <dbReference type="OMA" id="MVSVRIF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01565">
        <property type="entry name" value="ZntB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023714">
        <property type="entry name" value="Zn_transp_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000239249" description="Zinc transport protein ZntB">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="295"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="322"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01565"/>
        </source>
    </evidence>
    <sequence length="327" mass="36612" checksum="B3A83F420565775D" modified="2005-12-06" version="1">MEAIKGSDVNVPDAVFAWMLDGRGGVKPLENTDVIDEAHPCWLHLNYVHHDSAQWLATTPLLPNNVRDALAGESTRPRVSRLGEGTLITLRCINGSTDERPDQLVAMRVYMDGRLIVSTRQRKVLALDDVVSDLEEGTGPTDCGGWLVDVCDALTDHSSEFIEQLHDKIIDLEDNLLDQQIPPRGFLALLRKQLIVMRRYMAPQRDVYARLASERLPWMSDDQRRRMQDIADRLGRGLDEIDACIARTGVMADEIAQVMQENLARRTYTMSLMAMVFLPSTFLTGLFGVNLGGIPGGGWQFGFSIFCILLVVLIGGVALWLHRSKWL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-12-04" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GM1</accession>
    <name>STXA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Shiga toxin subunit A</fullName>
            <ecNumber>3.2.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">stxA</name>
        <name type="ordered locus">SDY_1389</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.</text>
            <dbReference type="EC" id="3.2.2.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Shiga toxin contains a single subunit A and five copies of subunit B.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribosome-inactivating protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.22"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000691354.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403025.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GM1"/>
    <dbReference type="SMR" id="Q32GM1"/>
    <dbReference type="EnsemblBacteria" id="ABB61534">
        <property type="protein sequence ID" value="ABB61534"/>
        <property type="gene ID" value="SDY_1389"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1389"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1650"/>
    <dbReference type="HOGENOM" id="CLU_870802_0_0_6"/>
    <dbReference type="OMA" id="CNMKIII"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030598">
        <property type="term" value="F:rRNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036041">
        <property type="entry name" value="Ribosome-inact_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001574">
        <property type="entry name" value="Ribosome_inactivat_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017988">
        <property type="entry name" value="Ribosome_inactivat_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016138">
        <property type="entry name" value="Ribosome_inactivat_prot_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016139">
        <property type="entry name" value="Ribosome_inactivat_prot_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016331">
        <property type="entry name" value="Shiga-like_toxin_subunit_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00161">
        <property type="entry name" value="RIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001924">
        <property type="entry name" value="Shigella_toxin_subunit_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56371">
        <property type="entry name" value="SSF56371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00275">
        <property type="entry name" value="SHIGA_RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0800">Toxin</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000312303" description="Shiga toxin subunit A">
        <location>
            <begin position="23"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="A1">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="A2">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by furin" evidence="1">
        <location>
            <begin position="273"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="315" mass="34814" checksum="8A423DF7ABF58F30" modified="2005-12-06" version="1" precursor="true">MKIIIFRVLTFFFVIFSVNVVAKEFTLDFSTAKTYVDSLNVIRSAIGTPLQTISSGGTSLLMIDSGTGDNLFAVDVRGIDPEEGRFNNLRLIVERNNLYVTGFVNRTNNVFYRFADFSHVTFPGTTAVTLSGDSSYTTLQRVAGISRTGMQINRHSLTTSYLDLMSHSGTSLTQSVARAMLRFVTVTAEALRFRQIQRGFRTTLDDLSGRSYVMTAEDVDLTLNWGRLSSVLPDYHGQDSVRVGRISFGSINAILGSVALILNCHHHASRVARMASDEFPSMCPADGRVRGITHNKILWDSSTLGAILMRRTISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GM8</accession>
    <name>Q32GM8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000186873.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403018.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GM8"/>
    <dbReference type="STRING" id="300267.SDY_1382"/>
    <dbReference type="EnsemblBacteria" id="ABB61527">
        <property type="protein sequence ID" value="ABB61527"/>
        <property type="gene ID" value="SDY_1382"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1382"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1642"/>
    <dbReference type="HOGENOM" id="CLU_065649_1_0_6"/>
    <dbReference type="OMA" id="FSMWVTR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ" evidence="1">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="226" mass="25954" checksum="3A661EB753B3EFD0" modified="2005-12-06" version="1">MTPDIILQRTGIDVRAVEQGDDAWHKLRLGVITASEVHNVIAKPRSGKKWPDMKMSYFHTLLAEVCTGVAPEVNAKALAWGKQYENDARVLFEFTSGVNVTESPIIYRDESMRTACSPDGLCSDGNGLELKCPFTSRDFMRFRLGGFEAIKSAYMAQVQYSMWVTRKDAWYFANYDPRMKREGLHYVVVERDEKYMAGFDEMVPEFIEKMDEALDEIGFVFGEQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GP0</accession>
    <name>Q32GP0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403006.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GP0"/>
    <dbReference type="EnsemblBacteria" id="ABB61515">
        <property type="protein sequence ID" value="ABB61515"/>
        <property type="gene ID" value="SDY_1370"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1370"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1625"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="97" mass="11022" checksum="411526E1C01AD253" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITKRIISKNENDHSHQVIGQETEMTSKLEIRHKQRRDEIIGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H76</accession>
    <name>Q32H76_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H76"/>
    <dbReference type="EnsemblBacteria" id="ABB61329">
        <property type="protein sequence ID" value="ABB61329"/>
        <property type="gene ID" value="SDY_1172"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1172"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_1_6"/>
    <dbReference type="OMA" id="SELMHDS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8422" checksum="48B98928F4135D00" modified="2005-12-06" version="1">MITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HA1</accession>
    <name>RUVB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvB</name>
        <name type="ordered locus">SDY_1147</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000568519.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402795.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HA1"/>
    <dbReference type="SMR" id="Q32HA1"/>
    <dbReference type="STRING" id="300267.SDY_1147"/>
    <dbReference type="EnsemblBacteria" id="ABB61304">
        <property type="protein sequence ID" value="ABB61304"/>
        <property type="gene ID" value="SDY_1147"/>
    </dbReference>
    <dbReference type="GeneID" id="66674250"/>
    <dbReference type="KEGG" id="sdy:SDY_1147"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1350"/>
    <dbReference type="HOGENOM" id="CLU_055599_1_0_6"/>
    <dbReference type="OMA" id="IHRMSRP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000235404" description="Holliday junction ATP-dependent DNA helicase RuvB">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <sequence length="336" mass="37174" checksum="79BAB4A9A5687F7C" modified="2005-12-06" version="1">MIEADRLISAGTTLPEDVADRAIRPKLLEEYVGQPQVRSQMEIFIKAAKLRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVPDLQYIVSRSARFMGLEMSDDGALEVARRARGTPRIANRLLRRVRDFAEVKHDGTISADIAAQALDMLNVDAEGFDYMDRKLLLAVIDKFFGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFLQRTPRGRMATTRAWNHFGITPPEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HC0</accession>
    <name>Q32HC0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, theta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">holE</name>
        <name evidence="1" type="ordered locus">SDY_1128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000916763.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402776.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HC0"/>
    <dbReference type="SMR" id="Q32HC0"/>
    <dbReference type="STRING" id="300267.SDY_1128"/>
    <dbReference type="EnsemblBacteria" id="ABB61285">
        <property type="protein sequence ID" value="ABB61285"/>
        <property type="gene ID" value="SDY_1128"/>
    </dbReference>
    <dbReference type="GeneID" id="66674268"/>
    <dbReference type="KEGG" id="sdy:SDY_1128"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1330"/>
    <dbReference type="HOGENOM" id="CLU_176900_0_0_6"/>
    <dbReference type="OMA" id="FRERYNM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009052">
        <property type="entry name" value="DNA_pol_III_theta_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036745">
        <property type="entry name" value="PolIII_theta_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06440">
        <property type="entry name" value="DNA_pol3_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46575">
        <property type="entry name" value="SSF46575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="76" mass="8846" checksum="3667D87327E96556" modified="2005-12-06" version="1">MLKNLAKLDQTEMDKVNVDLAAAGVAFKERYNMPVIAEAVEREQPEHLRSWFRERLIAHRLASVNLSRLPYEPKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HN3</accession>
    <name>Q32HN3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378633.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402663.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HN3"/>
    <dbReference type="EnsemblBacteria" id="ABB61172">
        <property type="protein sequence ID" value="ABB61172"/>
        <property type="gene ID" value="SDY_1007"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1007"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1175"/>
    <dbReference type="HOGENOM" id="CLU_184371_0_0_6"/>
    <dbReference type="OMA" id="SCIEQAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="65" mass="7330" checksum="4B75D64CB32F698C" modified="2005-12-06" version="1">MKSLTTETALDILIAWLLDNIDCESGIIFDNDEDKTDSAALLPCIEQAREGIRTLCQLQLLHQNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HT7</accession>
    <name>TUSE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Sulfurtransferase TusE</fullName>
            <ecNumber>2.8.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>tRNA 2-thiouridine synthesizing protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tusE</name>
        <name type="ordered locus">SDY_0944</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could accept sulfur from TusD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the TusBCD complex. Interacts with MnmA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DsrC/TusE family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB61118" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.8.1.-"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61118.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001301417.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402609.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HT7"/>
    <dbReference type="SMR" id="Q32HT7"/>
    <dbReference type="STRING" id="300267.SDY_0944"/>
    <dbReference type="EnsemblBacteria" id="ABB61118">
        <property type="protein sequence ID" value="ABB61118"/>
        <property type="gene ID" value="SDY_0944"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0944"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1092"/>
    <dbReference type="HOGENOM" id="CLU_153199_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042072">
        <property type="entry name" value="DsrC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025526">
        <property type="entry name" value="DsrC-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043163">
        <property type="entry name" value="DsrC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007453">
        <property type="entry name" value="DsrC/TusE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37010">
        <property type="entry name" value="PTHR37010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04358">
        <property type="entry name" value="DsrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006223">
        <property type="entry name" value="DsrC_TusE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69721">
        <property type="entry name" value="SSF69721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03342">
        <property type="entry name" value="dsrC_tusE_dsvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000234619" description="Sulfurtransferase TusE">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="109" mass="12400" checksum="6E83CFFAFEE97988" modified="2006-05-16" version="2">MLIFEGKEIETDTEGYLKESSQWSESLAVVIAENEGISLSPEHWEVVRFVRDFYLEFNTSPAIRMLVKAMANKFGEEKGNSRYLYRLFPKGPAKQATKIAGLPKPVKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HU7</accession>
    <name>Q32HU7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000839153.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402599.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HU7"/>
    <dbReference type="SMR" id="Q32HU7"/>
    <dbReference type="STRING" id="300267.SDY_0934"/>
    <dbReference type="EnsemblBacteria" id="ABB61108">
        <property type="protein sequence ID" value="ABB61108"/>
        <property type="gene ID" value="SDY_0934"/>
    </dbReference>
    <dbReference type="GeneID" id="66670765"/>
    <dbReference type="KEGG" id="sdy:SDY_0934"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1082"/>
    <dbReference type="HOGENOM" id="CLU_094990_0_0_6"/>
    <dbReference type="OMA" id="AICGTHQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007077">
        <property type="entry name" value="TfoX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007076">
        <property type="entry name" value="TfoX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026256">
        <property type="entry name" value="TfoX_Sxy"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04994">
        <property type="entry name" value="TfoX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04993">
        <property type="entry name" value="TfoX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028788">
        <property type="entry name" value="TfoX_Sxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfoX_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="TfoX_C" evidence="2">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="209" mass="24147" checksum="588AD41143C4F2DA" modified="2005-12-06" version="1">MKSLSYKRIYKSQEYLATLGTIEYRSLFGSYSLTVDDTVFAMVSDGELYLRACEQSAQYCVKHPPVWLTYKKCGRSVTLNYYRVDESLWRNQLKLVRLSKYSLDAALKEKSTRNTRERLKDLPNMSFHLEAILGEVGIKDVRALRILGAKMCWLRLRQQNSLVTEKILFMLEGAIIGIHEAALPVARRQELAEWADSLTPKQEFPAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I40</accession>
    <name>Q32I40_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_0835</name>
        <name evidence="5" type="ordered locus">SDY_1198</name>
        <name evidence="6" type="ordered locus">SDY_1644</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402506.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402842.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403259.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q32I40"/>
    <dbReference type="STRING" id="300267.SDY_0835"/>
    <dbReference type="EnsemblBacteria" id="ABB61017">
        <property type="protein sequence ID" value="ABB61017"/>
        <property type="gene ID" value="SDY_0835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61351">
        <property type="protein sequence ID" value="ABB61351"/>
        <property type="gene ID" value="SDY_1198"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61768">
        <property type="protein sequence ID" value="ABB61768"/>
        <property type="gene ID" value="SDY_1644"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0835"/>
    <dbReference type="KEGG" id="sdy:SDY_1198"/>
    <dbReference type="KEGG" id="sdy:SDY_1644"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1417"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="OMA" id="RPHSERC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11193" checksum="D287183B2AF0D61A" modified="2005-12-06" version="1">MSRKNQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGTLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKATAYFAQESLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I72</accession>
    <name>Q32I72_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402474.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I72"/>
    <dbReference type="STRING" id="300267.SDY_0803"/>
    <dbReference type="EnsemblBacteria" id="ABB60985">
        <property type="protein sequence ID" value="ABB60985"/>
        <property type="gene ID" value="SDY_0803"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0803"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.927"/>
    <dbReference type="HOGENOM" id="CLU_2008658_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="12616" checksum="5D83BAB09D9AB730" modified="2005-12-06" version="1">MDCSKCNGYATMLLNMVQGSDPVNLLELHGFLEHFAYYVSFGKFNAGHQRYNAFKKFVSEISEISANDINMTIKTGQSRHENVISINMNDAIPRDEKGITVRIDNVVMPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IP2</accession>
    <name>Q32IP2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IP2"/>
    <dbReference type="EnsemblBacteria" id="ABB60815">
        <property type="protein sequence ID" value="ABB60815"/>
        <property type="gene ID" value="SDY_0622"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0622"/>
    <dbReference type="HOGENOM" id="CLU_2720127_0_0_6"/>
    <dbReference type="OMA" id="FITIGFH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8238" checksum="A536ED735F2EE46D" modified="2005-12-06" version="1">MAFLCKGNKKSESYSSHLFVITANFLPNFITIGFHRLIISGLRCTQTLLIIQYADTFLVGKLLMLFLFLQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IP8</accession>
    <name>Q32IP8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">insA</name>
        <name evidence="2" type="ordered locus">SDY_0616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402298.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IP8"/>
    <dbReference type="STRING" id="300267.SDY_0616"/>
    <dbReference type="EnsemblBacteria" id="ABB60809">
        <property type="protein sequence ID" value="ABB60809"/>
        <property type="gene ID" value="SDY_0616"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0616"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.713"/>
    <dbReference type="HOGENOM" id="CLU_185339_0_0_6"/>
    <dbReference type="OMA" id="GQLQFTY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="1">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="101" mass="10984" checksum="0F2B698937AADE80" modified="2005-12-06" version="1">MYDGVFEVLQWLLFLSAVPPVQLLTGWCVTAKALPDISAISALTAVKHGQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVSLNTILRHLKNSGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J38</accession>
    <name>Q32J38_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ylaC</name>
        <name evidence="2" type="ordered locus">SDY_0461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402158.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J38"/>
    <dbReference type="STRING" id="300267.SDY_0461"/>
    <dbReference type="EnsemblBacteria" id="ABB60669">
        <property type="protein sequence ID" value="ABB60669"/>
        <property type="gene ID" value="SDY_0461"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0461"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.544"/>
    <dbReference type="HOGENOM" id="CLU_134298_0_0_6"/>
    <dbReference type="OMA" id="VDFYDVY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019713">
        <property type="entry name" value="Memb_YlaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10777">
        <property type="entry name" value="YlaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="169" mass="19821" checksum="F7FE930069357A3B" modified="2005-12-06" version="1">MFPGKLQIPRRQTMTEIQRLLTETIESLNTREKRDNKPRFSISFIRKHPGLFIGMYVAFFATLAVMLQSETLSGSVWLLVVLFILLNGFFFFDVYPRYRYEDIDVLDFRVCYNGEWYNTRFVPAALVEAILNSPRVADVHKEQLQKMIVRKGELSFYDIFTLARAESTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J95</accession>
    <name>YLBG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein YlbG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ylbG</name>
        <name type="ordered locus">SDY_0400</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="sequence caution" evidence="1">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60612" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60612.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402101.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J95"/>
    <dbReference type="SMR" id="Q32J95"/>
    <dbReference type="STRING" id="300267.SDY_0400"/>
    <dbReference type="EnsemblBacteria" id="ABB60612">
        <property type="protein sequence ID" value="ABB60612"/>
        <property type="gene ID" value="SDY_0400"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0400"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.474"/>
    <dbReference type="HOGENOM" id="CLU_067821_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000248937" description="Uncharacterized protein YlbG">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="123" mass="13916" checksum="9BC21818DAACC0A1" modified="2006-09-05" version="2">MLHTANPVIKHKAGLLNLAEELSNVSKACKIMGVSRDTFYRYRELVAEGGVDAQINRSRRAPNLKNRTDEATEQAVVDYAVAFPTHGQHRASNELRKQGVFISDSGVRSVWLLHNLENLKRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JF0</accession>
    <name>Q32JF0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclease SbcCD subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">sbcC</name>
        <name evidence="4" type="ordered locus">SDY_0341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SbcC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000698860.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402046.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JF0"/>
    <dbReference type="STRING" id="300267.SDY_0341"/>
    <dbReference type="EnsemblBacteria" id="ABB60557">
        <property type="protein sequence ID" value="ABB60557"/>
        <property type="gene ID" value="SDY_0341"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0341"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.397"/>
    <dbReference type="HOGENOM" id="CLU_004785_1_0_6"/>
    <dbReference type="OMA" id="ISHVQEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004592">
        <property type="entry name" value="SbcC_gammaproteobac_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00618">
        <property type="entry name" value="sbcc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1 4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="5"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="539"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="772"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1045" mass="118274" checksum="6988D5A66D868F2C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JF3</accession>
    <name>Q32JF3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Branched-chain amino acid transport system carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">brnQ</name>
        <name evidence="9" type="ordered locus">SDY_0336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the transport system for branched-chain amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000149639.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402043.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JF3"/>
    <dbReference type="STRING" id="300267.SDY_0336"/>
    <dbReference type="EnsemblBacteria" id="ABB60554">
        <property type="protein sequence ID" value="ABB60554"/>
        <property type="gene ID" value="SDY_0336"/>
    </dbReference>
    <dbReference type="GeneID" id="66671300"/>
    <dbReference type="KEGG" id="sdy:SDY_0336"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.387"/>
    <dbReference type="HOGENOM" id="CLU_036807_0_0_6"/>
    <dbReference type="OMA" id="IWPAGPI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="439" mass="46209" checksum="B30C3B5755738E0E" modified="2005-12-06" version="1">MTHQLRSRDIIALGFMTFALFVGAGNIIFPPMVGLQAGEHVWTAAFGFLITAVGLPVLTVVALAKVGGGVDSLSTPIGKVAGVLLATVCYLAVGPLFATPRTATVSFEVGIAPLTGDSALPLFIYSLVYFAIVILVSLYPGKLLDTVGNFLAPLKIIALVILSVAAIVWPAGSISTATEAYQNAAFSNGFVNGYLTMDTLGAMVFGIVIVNAARSRGVTEARLLTRYTVWAGLMAGVGLTLLYLALFRLGSDSASLVDQSANGAAILHAYVQHTFGGGGSFLLAALIFIACLVTAVGLTCACAEFFAQYVPLSYRTLVFILGGFSMVVSNLGLSQLIQISVPVLTAIYPPCIALVVLSFTRSWWHNSSRVIAPPMFISLLFGILDGIKASAFSDILPSWAQRLPLAEQGLAWLMPTVVMVVLAIIWDRAAGRQVTSSAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JG0</accession>
    <name>TGT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tgt</name>
        <name type="ordered locus">SDY_0328</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000667319.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402036.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JG0"/>
    <dbReference type="SMR" id="Q32JG0"/>
    <dbReference type="STRING" id="300267.SDY_0328"/>
    <dbReference type="EnsemblBacteria" id="ABB60547">
        <property type="protein sequence ID" value="ABB60547"/>
        <property type="gene ID" value="SDY_0328"/>
    </dbReference>
    <dbReference type="GeneID" id="66671295"/>
    <dbReference type="KEGG" id="sdy:SDY_0328"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.377"/>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_6"/>
    <dbReference type="OMA" id="GIDLFDC"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000016855" description="Queuine tRNA-ribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="1">
        <location>
            <begin position="245"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="1">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="89"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <sequence length="375" mass="42594" checksum="40271CA08D8A8820" modified="2005-12-06" version="1">MKFELDTTDGRARRGRLVFDRGVVETPCFMPVGTYGTVKGMTPEEVEATGAQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDPIFLDPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRERFDSLGNKNALFGIIQGSVYEDLRDISVKGLVDIGFDGYAVGGLAVGEPKADMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKYKSDTGPLDPECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRKAIEEGKLESFVTDFYQRQGREVPPLNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JL7</accession>
    <name>Q32JL7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ylbF</name>
        <name evidence="1" type="ordered locus">SDY_0270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000152507.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401979.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JL7"/>
    <dbReference type="STRING" id="300267.SDY_0270"/>
    <dbReference type="EnsemblBacteria" id="ABB60490">
        <property type="protein sequence ID" value="ABB60490"/>
        <property type="gene ID" value="SDY_0270"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0270"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.309"/>
    <dbReference type="HOGENOM" id="CLU_072005_2_0_6"/>
    <dbReference type="OMA" id="VSCAYLH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021530">
        <property type="entry name" value="DUF2877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11392">
        <property type="entry name" value="DUF2877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="271" mass="29768" checksum="FBC4744EC41F68FB" modified="2005-12-06" version="1">MTIIHPLLASRSAPDYRQPWRLAGVWRRAINLMTESGELLTLHRQGSGFGPGGWGLRRAQFDALCGELCGNERPQVVAQGIRLGRFTVKQPQRYCLLRITPPAHPQPLAAAWMQRAEETGLFGPLALAASDPLPAELRQFRHCFQAALNGVKTDWRHWLGKGPGLTPSHDDTLSGMLLAAWYYGALDARSDRQFFACSDNLQLVTTAVSVSYLRYAAQGYFASPLLHFAHALSCPKRTAVAIDSLLALGHTSGADTLLGFWLGQQLLQGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JN4</accession>
    <name>Q32JN4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yafK</name>
        <name evidence="6" type="ordered locus">SDY_0250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001225679.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401962.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JN4"/>
    <dbReference type="SMR" id="Q32JN4"/>
    <dbReference type="STRING" id="300267.SDY_0250"/>
    <dbReference type="MEROPS" id="C82.A01"/>
    <dbReference type="EnsemblBacteria" id="ABB60473">
        <property type="protein sequence ID" value="ABB60473"/>
        <property type="gene ID" value="SDY_0250"/>
    </dbReference>
    <dbReference type="GeneID" id="66671457"/>
    <dbReference type="KEGG" id="sdy:SDY_0250"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.281"/>
    <dbReference type="HOGENOM" id="CLU_032558_2_0_6"/>
    <dbReference type="OMA" id="MAQIYAF"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221168" description="YkuD domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="45"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="246" mass="28021" checksum="D2B6686353D9735A" modified="2005-12-06" version="1">MRKIALILAMLLIPCVSFAGLLGSSSSTTPVSKEYKQQLMGSPVYIQIFKEERTLDLYVKMGEQYQLLDSYKICKYSGGLGPKQRQGDFKSPEGFYSVQRNQLKPDSRYYKAINIGFPNAYDRAHGYEGKYLMIHGDCVSIGCYAMTNQGIDEIFQFVTGALVFGQPSVQVSIYPFRMTDANMKRHKYSNFKDFWEQLKPGYDYFEQTRKPPTVSVVNGRYVVSKPLSHEVVQPQLASNYTLPEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JS1</accession>
    <name>Q32JS1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yaeR</name>
        <name evidence="2" type="ordered locus">SDY_0205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401925.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JS1"/>
    <dbReference type="STRING" id="300267.SDY_0205"/>
    <dbReference type="EnsemblBacteria" id="ABB60436">
        <property type="protein sequence ID" value="ABB60436"/>
        <property type="gene ID" value="SDY_0205"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0205"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.239"/>
    <dbReference type="HOGENOM" id="CLU_046006_2_4_6"/>
    <dbReference type="OMA" id="MNICRVH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08352">
        <property type="entry name" value="VOC_Bs_YwkD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037478">
        <property type="entry name" value="YwkD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="110" mass="12634" checksum="7C0580D0BAC637F0" modified="2005-12-06" version="1">MSKAFYCDILGFTLQSEVYREARDSWKGDLALNGQYVIELFSFPFPPERPSRPEACGLRHLAFSVDDIDAAVAHLESHNVKCEAIRVDPYTQKRFTFFNDPDGLPLELYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JV9</accession>
    <name>Q32JV9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Penicillin-binding protein 1B</fullName>
            <shortName evidence="13">PBP-1b</shortName>
            <shortName evidence="13">PBP1b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Murein polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">mrcB</name>
        <name evidence="21" type="ordered locus">SDY_0165</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000232983.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401887.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JV9"/>
    <dbReference type="STRING" id="300267.SDY_0165"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60398">
        <property type="protein sequence ID" value="ABB60398"/>
        <property type="gene ID" value="SDY_0165"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0165"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.190"/>
    <dbReference type="HOGENOM" id="CLU_006354_2_7_6"/>
    <dbReference type="OMA" id="VHGMGLA"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009274">
        <property type="term" value="C:peptidoglycan-based cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032730">
        <property type="entry name" value="PBP1b_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011813">
        <property type="entry name" value="PBP_1b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028166">
        <property type="entry name" value="UB2H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14812">
        <property type="entry name" value="PBP1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14814">
        <property type="entry name" value="UB2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002799">
        <property type="entry name" value="PBP_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02071">
        <property type="entry name" value="PBP_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0133">Cell shape</keyword>
    <keyword evidence="13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PBP1_TM" evidence="19">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="UB2H" evidence="20">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="18">
        <location>
            <begin position="209"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="17">
        <location>
            <begin position="473"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="792"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="792"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for transglycosylase activity" evidence="14">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate; for transpeptidase activity" evidence="14">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002799-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ABB60398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="844" mass="94322" checksum="C861885805BFEE89" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K59</accession>
    <name>CAIB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-carnitine CoA-transferase</fullName>
            <ecNumber evidence="1">2.8.3.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Crotonobetainyl-CoA:carnitine CoA-transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">caiB</name>
        <name type="ordered locus">SDY_0060</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-carnitine + crotonobetainyl-CoA = (R)-carnitinyl-CoA + crotonobetaine</text>
            <dbReference type="Rhea" id="RHEA:28526"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:17237"/>
            <dbReference type="ChEBI" id="CHEBI:60932"/>
            <dbReference type="ChEBI" id="CHEBI:60933"/>
            <dbReference type="EC" id="2.8.3.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-carnitine + gamma-butyrobetainyl-CoA = (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate</text>
            <dbReference type="Rhea" id="RHEA:28418"/>
            <dbReference type="ChEBI" id="CHEBI:16244"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:60932"/>
            <dbReference type="ChEBI" id="CHEBI:61513"/>
            <dbReference type="EC" id="2.8.3.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine metabolism; carnitine metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family. CaiB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000349923.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401787.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K59"/>
    <dbReference type="SMR" id="Q32K59"/>
    <dbReference type="STRING" id="300267.SDY_0060"/>
    <dbReference type="PRIDE" id="Q32K59"/>
    <dbReference type="EnsemblBacteria" id="ABB60298">
        <property type="protein sequence ID" value="ABB60298"/>
        <property type="gene ID" value="SDY_0060"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0060"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.66"/>
    <dbReference type="HOGENOM" id="CLU_033975_2_0_6"/>
    <dbReference type="OMA" id="HRPGFGT"/>
    <dbReference type="UniPathway" id="UPA00117"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01050">
        <property type="entry name" value="CaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023452">
        <property type="entry name" value="CoA-Trfase_CaiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000300983" description="L-carnitine CoA-transferase">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01050"/>
        </source>
    </evidence>
    <sequence length="405" mass="45168" checksum="EE83CEED4EECD2A0" modified="2005-12-06" version="1">MDHLPMPKFGPLAGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAWADTIRVQPNYPQLSRRNLHALSLNIFKDEGREAFLKLMETTDIFIEASKGPAFARRGITDEVLWQHNPKLVIAHLSGFGQYGTEEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGLTATTAALAALHKARETGKGESIDIAMYEVMLRMGQYFMMDYFNGGEMCPRMSKGKDPYYAGCGLYKCADGYIVMELVGITQIEECFKDIGLAHLLGTPEIPEGTQLIHRIECPYGPLVEEKLDAWLAAHTIAEVKERFAELNIACAKVLTVPELESNPQYVARESITQWQTMDGRTCKRPNIMPKFKNNPGQIWRGMPSHGMDTAAILKNIGYSENDIQELVSKGLAKVED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KB2</accession>
    <name>YAAA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0246 protein YaaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yaaA</name>
        <name type="ordered locus">SDY_0006</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0246 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000906209.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401734.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KB2"/>
    <dbReference type="SMR" id="Q32KB2"/>
    <dbReference type="STRING" id="300267.SDY_0006"/>
    <dbReference type="EnsemblBacteria" id="ABB60246">
        <property type="protein sequence ID" value="ABB60246"/>
        <property type="gene ID" value="SDY_0006"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0006"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5"/>
    <dbReference type="HOGENOM" id="CLU_061989_0_0_6"/>
    <dbReference type="OMA" id="WKNGQYK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00652">
        <property type="entry name" value="UPF0246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000262061" description="UPF0246 protein YaaA">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00652"/>
        </source>
    </evidence>
    <sequence length="258" mass="29630" checksum="6CC08748DFD68DF6" modified="2005-12-06" version="1">MLILISPAKTLDYQSPLTTTRYTLPELLDNSQQLIHEARKLTPPQISTLMRISDKLAGINAARFHDWQPDFTPENARQAILAFKGDVYTGLQAETFSEDDFDFTQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENARGKDLYQFWGDIITNKLNEALAAQGDNVVINLASDEYFKSVKPKKLNAEIIKPVFLDEKNGKFKIISFYAKKARGLMSRFIIENRLTKPEQLTGFNSEGYFFDEASSSNGELVFKRYEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q326M8</accession>
    <name>Q326M8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS629 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406218.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326M8"/>
    <dbReference type="EnsemblBacteria" id="ABB64730">
        <property type="protein sequence ID" value="ABB64730"/>
        <property type="gene ID" value="SDY_P217"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P217"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5771"/>
    <dbReference type="HOGENOM" id="CLU_027402_41_1_6"/>
    <dbReference type="OMA" id="WVRTTIS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="36"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="207" mass="23542" checksum="42A19DA3FD0A4785" modified="2005-12-06" version="1">MTLLYQLELFLFRTWVRTTISRKAVAAGDRVNRQFVAERPDQLWVADFTYVSTWQGFVYVAFIIDVFAGYIVGWRVSSSMETTFVLDALEQALWARRPSGTVHHSDKGSQYVSLAYTQRLKEAGLLASTGSTGDSYDNAMAESINGLYKAEVIHRKSWKNRAEVELATLTWVDWYNNRRLLERLGYTPPAEAEKAYYASIGNDDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Q2</accession>
    <name>Q326Q2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Spa40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">spa40</name>
        <name evidence="8" type="ordered locus">SDY_P193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Sd197</strain>
            <plasmid evidence="9">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type III secretion exporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001284685.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406194.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Q2"/>
    <dbReference type="EnsemblBacteria" id="ABB64706">
        <property type="protein sequence ID" value="ABB64706"/>
        <property type="gene ID" value="SDY_P193"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P193"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5745"/>
    <dbReference type="HOGENOM" id="CLU_041013_1_3_6"/>
    <dbReference type="OMA" id="QPNPGAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006307">
        <property type="entry name" value="BsaZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01404">
        <property type="entry name" value="FlhB_rel_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="342" mass="39787" checksum="47F0058AAEEA98B6" modified="2005-12-06" version="1">MANKTEKPTPKKLKDAAKKGQSFKFKDLTTVVIILVGTFTIISFFSLSDVMLLYRYVIINDFEINEGKYFFAVVIVFFKIIGFPLFFCVLSAVLPTLVQTKFVLATKAIKIDFSVLNPVKGLKKIFSIKTIKEFFKSILLLIILALTTYFFWINDRKIIFSQVFSSVDGLYLIWGGLFKDIILFFLAFSIFVIILDFVIEFILYMKDMMMDKQEIKREYIEQEGHFETKSRRRELHIEILSEQTKSDIRNSKLVVMNPTHIAIGIYFNPEIAPAPFISLIETNQCALAVRKYANEVGIPTVRDVKLARKLYKTHTKYSFVDFEHLDEVLRLIVWLEQVENTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q326R0</accession>
    <name>Q326R0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MxiA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mxiA</name>
        <name evidence="11" type="ordered locus">SDY_P185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="11 12">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Sd197</strain>
            <plasmid evidence="12">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406186.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326R0"/>
    <dbReference type="EnsemblBacteria" id="ABB64698">
        <property type="protein sequence ID" value="ABB64698"/>
        <property type="gene ID" value="SDY_P185"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P185"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5737"/>
    <dbReference type="HOGENOM" id="CLU_015346_3_0_6"/>
    <dbReference type="OMA" id="MGSFYIE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025505">
        <property type="entry name" value="FHIPEP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006302">
        <property type="entry name" value="T3SS_HrcV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01399">
        <property type="entry name" value="hrcV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00994">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0614">Plasmid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB64698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="688" mass="76447" checksum="13D8802372FD0F45" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q326R3</accession>
    <name>Q326R3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MxiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mxiE</name>
        <name evidence="3" type="ordered locus">SDY_P182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000398257.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406183.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326R3"/>
    <dbReference type="EnsemblBacteria" id="ABB64695">
        <property type="protein sequence ID" value="ABB64695"/>
        <property type="gene ID" value="SDY_P182"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P182"/>
    <dbReference type="HOGENOM" id="CLU_082966_1_0_6"/>
    <dbReference type="OMA" id="LESYWLA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="99"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="210" mass="24538" checksum="ACAFC227B8249713" modified="2005-12-06" version="1">MEGFFFVRNQNIKFSDNVNYHYRFNINSCAKFLAFWDYFSGALVEHSHAEKCIHFYHENDLRDSCNTESMLDKLMLKFIFSSDQNVSNALAMIRMTESYHLVLYLLRTIEKEKEVRIKSLTEHYGVSEAYFRTLCRKALGAKVKEQLNTWRLVNGLLDVFLHNQTITSAAMNNGYASTSHFSNEIKTRLGFSARELSNITFLVKKINEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q326S6</accession>
    <name>Q326S6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IpgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ipgA</name>
        <name evidence="1" type="ordered locus">SDY_P169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010921664.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406170.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326S6"/>
    <dbReference type="EnsemblBacteria" id="ABB64682">
        <property type="protein sequence ID" value="ABB64682"/>
        <property type="gene ID" value="SDY_P169"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P169"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5727"/>
    <dbReference type="HOGENOM" id="CLU_1947354_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="129" mass="15085" checksum="8780F5B428A78847" modified="2005-12-06" version="1">MCRKLYDKLYEITGAKLDFNDKNQAFILLEEQIPVCITDNDEYIFLTGLLNEHELFTENIINPEHILILNYSLSRDYGSSICLLPDTHQCVLTKKHYKKYLSPDELIESLYEFLFCIKLTIANITSEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Y5</accession>
    <name>Q326Y5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipid A biosynthesis myristoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.243</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Kdo(2)-lauroyl-lipid IV(A) myristoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">msbB2</name>
        <name evidence="6" type="synonym">lpxM</name>
        <name evidence="7" type="ordered locus">SDY_P110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Sd197</strain>
            <plasmid evidence="8">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] = alpha-Kdo-(2-&gt;4)-alpha-Kdo-(2-&gt;6)-lipid A + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:28438"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:58540"/>
            <dbReference type="ChEBI" id="CHEBI:61524"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="2.3.1.243"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.243" evidence="6"/>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004996485.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406111.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Y5"/>
    <dbReference type="SMR" id="Q326Y5"/>
    <dbReference type="EnsemblBacteria" id="ABB64623">
        <property type="protein sequence ID" value="ABB64623"/>
        <property type="gene ID" value="SDY_P110"/>
    </dbReference>
    <dbReference type="GeneID" id="58462862"/>
    <dbReference type="KEGG" id="sdy:SDY_P110"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5665"/>
    <dbReference type="HOGENOM" id="CLU_049421_1_0_6"/>
    <dbReference type="OMA" id="GKMHARQ"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00360">
        <property type="reaction ID" value="UER00486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009276">
        <property type="term" value="C:Gram-negative-bacterium-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019107">
        <property type="term" value="F:myristoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036104">
        <property type="term" value="P:Kdo2-lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01944">
        <property type="entry name" value="Lipid_A_LpxM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011921">
        <property type="entry name" value="Lipid_A_MsbB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026649">
        <property type="entry name" value="MsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02208">
        <property type="entry name" value="lipid_A_msbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXXXXD motif" evidence="6">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="314" mass="36584" checksum="15F8C6CA972857BA" modified="2005-12-06" version="1">MKKYKSEFIPEFKKNYLSPVYWFTWFVLGMIAGISMFPPSFRDPVLAKIGRWVGRLSRKARRRATINLSLCFPEKSDTEREIIVDNMFATALQSIVMMAELAIRGPEKFQKRVFWKGLEILEEIRHNNRNVIFLVPHGWSVDIPAMLLAAQGEKMAAMFHQQRNPVIDYVWNSVRRKFGGRLHSREDGIKPFIQSVRQGYWGYYLPDQDHGPEYSEFADFFATYKATLPIIGRLMNISQAMIIPLFPVYDEKKHFLTIEVRPPMDACIASADNKMIARQMNKTVEILVGSHPEQYIWVLKLLKTRKSNEADPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q327C6</accession>
    <name>Q327C6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ISSfl1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406070.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327C6"/>
    <dbReference type="EnsemblBacteria" id="ABB64582">
        <property type="protein sequence ID" value="ABB64582"/>
        <property type="gene ID" value="SDY_P069"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P069"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5617"/>
    <dbReference type="HOGENOM" id="CLU_2685825_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="74" mass="7940" checksum="3975EC8CA74A6065" modified="2005-12-06" version="1">MINIIFNRLLSLLDANGFIDWSATALDGSNIRALKCAAGAQKNIPISTEIMGRVALAAVLAPKSIWQQTEVASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q327F0</accession>
    <name>Q327F0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ipaH1.4</name>
        <name evidence="13" type="ordered locus">SDY_P045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="13 14">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Sd197</strain>
            <plasmid evidence="14">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LRR-containing bacterial E3 ligase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406046.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327F0"/>
    <dbReference type="EnsemblBacteria" id="ABB64558">
        <property type="protein sequence ID" value="ABB64558"/>
        <property type="gene ID" value="SDY_P045"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P045"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5590"/>
    <dbReference type="HOGENOM" id="CLU_018533_2_0_6"/>
    <dbReference type="OMA" id="TPFPLPM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032674">
        <property type="entry name" value="LRR_E3_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029487">
        <property type="entry name" value="NEL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14496">
        <property type="entry name" value="NEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12468">
        <property type="entry name" value="TTSSLRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0614">Plasmid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="TTSSLRR" evidence="11">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="NEL" evidence="12">
        <location>
            <begin position="299"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB64558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="582" mass="65688" checksum="DA96ECF9D127D214" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q327J7</accession>
    <name>Q327J7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Catabolic regulation response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">creB</name>
        <name evidence="6" type="ordered locus">SDY_4659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001188664.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405999.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327J7"/>
    <dbReference type="SMR" id="Q327J7"/>
    <dbReference type="STRING" id="300267.SDY_4659"/>
    <dbReference type="EnsemblBacteria" id="ABB64508">
        <property type="protein sequence ID" value="ABB64508"/>
        <property type="gene ID" value="SDY_4659"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4659"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5521"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_6"/>
    <dbReference type="OMA" id="KRLGEPW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="229" mass="26113" checksum="42710A577C407A18" modified="2005-12-06" version="1">MQRETVWLVEDEQGIADTLVYMLQQEGFAVEVFERGLPVLDKARQQAPDVMILDVGLPDISGFELCRQLLALHPALPVLFLTARSEEVDRLLGLEIGADDYVAKPFSPREVCARVRTLLRRVKKFSSPSPVIRIGHFELNEPAAQISWFDTPLTLTRYEFLLLKTLLKSPGRVWSRQQLMDSVWEDAQDTYDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q327L0</accession>
    <name>Q327L0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000566154.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405986.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327L0"/>
    <dbReference type="EnsemblBacteria" id="ABB64495">
        <property type="protein sequence ID" value="ABB64495"/>
        <property type="gene ID" value="SDY_4646"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4646"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5508"/>
    <dbReference type="HOGENOM" id="CLU_2584150_0_0_6"/>
    <dbReference type="OMA" id="EVINLMF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="10042" checksum="8985F126E80F25F4" modified="2005-12-06" version="1">MIDLENQEREIINLMLSQRISWLAAVRIRHKLSLAEVSKMLGISINSLKQIEKTERFSSNIKSKMAEIYGCPPELLICPSWMTAEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Q3</accession>
    <name>Q327Q3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000976841.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405943.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Q3"/>
    <dbReference type="STRING" id="300267.SDY_4592"/>
    <dbReference type="EnsemblBacteria" id="ABB64452">
        <property type="protein sequence ID" value="ABB64452"/>
        <property type="gene ID" value="SDY_4592"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4592"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5436"/>
    <dbReference type="HOGENOM" id="CLU_114884_0_0_6"/>
    <dbReference type="OMA" id="RCYGVSL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046025">
        <property type="entry name" value="DUF5983"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19419">
        <property type="entry name" value="DUF5983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="163" mass="18220" checksum="45B65B274BA69760" modified="2005-12-06" version="1">MMKLALTLEADSVNVQALNMGRIVVDIDGVNLAELINMVCDNGYSLRVVDESDRTSADCTPPFVALTGIRCSTAHITETDNAWLYSLSHQTSDFGESEWIHFTGTGYLLRTDAWSYPVLRFKRLGLSKTFRRLVVTLIRRYGVSLIHLDASAGYLPGLPTFDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Q4</accession>
    <name>Q327Q4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YeeT/YkfH/YpjJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000692345.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405942.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Q4"/>
    <dbReference type="EnsemblBacteria" id="ABB64451">
        <property type="protein sequence ID" value="ABB64451"/>
        <property type="gene ID" value="SDY_4591"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4591"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5432"/>
    <dbReference type="HOGENOM" id="CLU_201031_0_0_6"/>
    <dbReference type="OMA" id="GEAMHIH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009329">
        <property type="entry name" value="DUF987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06174">
        <property type="entry name" value="DUF987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="73" mass="8409" checksum="681EAD11618C197C" modified="2005-12-06" version="1">MKIITRGEAMRIHRQHPASRLFPFCTGKYRWHGSAEAYTGREVQDIPGVLAVFAERRKDSFGPYVRLMSVTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q328A0</accession>
    <name>Q328A0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ISSfl4 ORF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_4479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000998102.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405846.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328A0"/>
    <dbReference type="STRING" id="300267.SDY_4479"/>
    <dbReference type="EnsemblBacteria" id="ABB64355">
        <property type="protein sequence ID" value="ABB64355"/>
        <property type="gene ID" value="SDY_4479"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4479"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5289"/>
    <dbReference type="HOGENOM" id="CLU_023034_0_1_6"/>
    <dbReference type="OMA" id="HADMNMA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039552">
        <property type="entry name" value="IS66_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024463">
        <property type="entry name" value="Transposase_TnpC_homeodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024474">
        <property type="entry name" value="Znf_dom_IS66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13817">
        <property type="entry name" value="DDE_Tnp_IS66_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13007">
        <property type="entry name" value="LZ_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13005">
        <property type="entry name" value="zf-IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LZ_Tnp_IS66" evidence="4">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="zf-IS66" evidence="3">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="2">
        <location>
            <begin position="176"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66_C" evidence="5">
        <location>
            <begin position="468"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="512" mass="57646" checksum="B35A348E568140BE" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q328X7</accession>
    <name>G6PI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="1">GPI</shortName>
            <ecNumber evidence="1">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoglucose isomerase</fullName>
            <shortName evidence="1">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphohexose isomerase</fullName>
            <shortName evidence="1">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgi</name>
        <name type="ordered locus">SDY_4226</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000789986.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405619.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328X7"/>
    <dbReference type="SMR" id="Q328X7"/>
    <dbReference type="STRING" id="300267.SDY_4226"/>
    <dbReference type="EnsemblBacteria" id="ABB64128">
        <property type="protein sequence ID" value="ABB64128"/>
        <property type="gene ID" value="SDY_4226"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4226"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4977"/>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_6"/>
    <dbReference type="OMA" id="IGVWYIN"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000230934" description="Glucose-6-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <sequence length="549" mass="61530" checksum="74AEDB670A068A01" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Z4</accession>
    <name>Q328Z4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Z4"/>
    <dbReference type="STRING" id="300267.SDY_4206"/>
    <dbReference type="EnsemblBacteria" id="ABB64110">
        <property type="protein sequence ID" value="ABB64110"/>
        <property type="gene ID" value="SDY_4206"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4206"/>
    <dbReference type="HOGENOM" id="CLU_2604130_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="79" mass="8438" checksum="596C64315AADB786" modified="2005-12-06" version="1">MVRRLRFSGPKTSIICSPMTSLKTSIKTITYLSDTGCLEIQGASLNRLINSGIVSLSLITEIANAVARLTLADLSKAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q329N1</accession>
    <name>Q329N1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-galactose:(Galactosyl) LPS alpha1,2-galactosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">waaW</name>
        <name evidence="2" type="ordered locus">SDY_4056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000364806.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405465.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329N1"/>
    <dbReference type="STRING" id="300267.SDY_4056"/>
    <dbReference type="CAZy" id="GT8">
        <property type="family name" value="Glycosyltransferase Family 8"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63974">
        <property type="protein sequence ID" value="ABB63974"/>
        <property type="gene ID" value="SDY_4056"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4056"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4772"/>
    <dbReference type="HOGENOM" id="CLU_050833_5_0_6"/>
    <dbReference type="OMA" id="HFTGHDK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008918">
        <property type="term" value="F:lipopolysaccharide 3-alpha-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013645">
        <property type="entry name" value="Glyco_transf_8N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08437">
        <property type="entry name" value="Glyco_transf_8C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_8C" evidence="1">
        <location>
            <begin position="278"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="342" mass="39354" checksum="EA82DA98F192DA37" modified="2005-12-06" version="1">MDLLAESITEVAVSGEIANTERVLNIAYGIDRNFLFGAAVSMQSVVMHNPDLAVKFHLFTDYIDEDYLQRVNAFTSKNANVEVIIYKVSNAFIDIFPSLKQWSYATFFRLVAFQYLSETIENLLYIDADVICKGSLAGLLDINFDGDKFAAVIKDVPFMQEKPAKRLAIEGLPGNYFNAGVVYLQLEAWAKNDFMNKAIAMLASDPQHTKYKCLDQDILNILFFGHCIFISGDYDCFYGIDYELKNKSDEDYKKTITDDTKLIHYVGVTKPWNDWTNYPCQNYFNEAYQASCWNDVAFIPATNEKQYQVKSRHLKRNGNIASSFYYFILYYSKKIARKHFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Q2</accession>
    <name>Q329Q2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">SDY_4035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405444.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Q2"/>
    <dbReference type="STRING" id="300267.SDY_4035"/>
    <dbReference type="EnsemblBacteria" id="ABB63953">
        <property type="protein sequence ID" value="ABB63953"/>
        <property type="gene ID" value="SDY_4035"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4035"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4750"/>
    <dbReference type="HOGENOM" id="CLU_990040_0_0_6"/>
    <dbReference type="OMA" id="YIPGHAN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008640">
        <property type="entry name" value="Adhesin_Head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008635">
        <property type="entry name" value="Coiled_stalk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005594">
        <property type="entry name" value="YadA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03895">
        <property type="entry name" value="YadA_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05658">
        <property type="entry name" value="YadA_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05662">
        <property type="entry name" value="YadA_stalk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="YadA_head" evidence="11">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="11">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="12">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="12">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_anchor" evidence="10">
        <location>
            <begin position="218"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="278" mass="28621" checksum="ED749A89BF289B73" modified="2005-12-06" version="1">MKVTDERVTQNTQSITNLNNQVTNLDTRVTNIENGIGDIVTTGSTKYFKTNTDGVDANAQGKDSVAIGSGSIAAADNSVALGTGSVANEENTISVGSSTKQRRITNVAAGVNATDAVNVSQLKSSEAGGVRYDTKADGSIDYSNITLGGGNGSTTRISNVSAGVNNNDAVNYAQLKQSVQETKQYTDQRMVEMDNKLSKTESKLSGGIASAMAMTGLPQAYTPGASMASIGGGTYNGESAVALGVSMVSANGRWVYKLQGSTNSQGEYSAALGAGIQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A24</accession>
    <name>Q32A24_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Trk system potassium uptake protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">trkH</name>
        <name evidence="14" type="ordered locus">SDY_3896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000545677.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405322.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A24"/>
    <dbReference type="SMR" id="Q32A24"/>
    <dbReference type="STRING" id="300267.SDY_3896"/>
    <dbReference type="EnsemblBacteria" id="ABB63831">
        <property type="protein sequence ID" value="ABB63831"/>
        <property type="gene ID" value="SDY_3896"/>
    </dbReference>
    <dbReference type="GeneID" id="66672245"/>
    <dbReference type="KEGG" id="sdy:SDY_3896"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4604"/>
    <dbReference type="HOGENOM" id="CLU_030708_0_2_6"/>
    <dbReference type="OMA" id="LQWMGGM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006247">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00933">
        <property type="entry name" value="2a38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006247-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB63831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="483" mass="52960" checksum="1AA9CC2F83EB509A" modified="2005-12-06" version="1">MHFRAITRIVGLLVILFSGTMIIPGLVALIYRDGAGRAFTQTFFVALAIGSMLWWPNRKEKGELKSREGFLIVVLFWTVLGSVGALPFIFSESPNLTITDAFFESFSGLTTTGATTLVGLDSLPHAILFYRQMLQWFGGMGIIVLAVAILPILGVGGMQLYRAEMPGPLKDNKMRPRIAETAKTLWLIYVLLTVACALALWFAGMDAFDAIGHSFATIAIGGFSTHDASIGYFDSPTINTIIAIFLLISGCNYGLHFSLLSGRSLKVYWRDPEFRMFIGVQFTLVVICTLVLWFHNVYSSALMTINQAFFQVVSMATTAGFTTDSIARWPLFLPVLLLCSAFIGGCAGSTGGGLKVIRILLLFKQGNRELKRLVHPNAVYSIKLGNRALPERILEAVWGFFSAYALVFIVSMLAIIATGVDDFSAFASVVATLNNLGPGLGVVADNFTSMNPVAKWILIANMLFGRLEVFTLLVLFTPTFWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A34</accession>
    <name>Q32A34_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yihG</name>
        <name evidence="3" type="ordered locus">SDY_3880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378914.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405312.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A34"/>
    <dbReference type="STRING" id="300267.SDY_3880"/>
    <dbReference type="EnsemblBacteria" id="ABB63821">
        <property type="protein sequence ID" value="ABB63821"/>
        <property type="gene ID" value="SDY_3880"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3880"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4591"/>
    <dbReference type="HOGENOM" id="CLU_054727_0_1_6"/>
    <dbReference type="OMA" id="HHSWADI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="97"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="310" mass="36372" checksum="9DD2F1CE5B600974" modified="2005-12-06" version="1">MANLLNKFIMTRILAAITLLLSIVLTILVTIFCSVPIIIAGIVKLLLPVPVIWRKVSRFCDFMMYCWCEGLAVLLHLNPHLQWEVHRLEGLSKKNWYLLICNHRSWADIVVLCVLFRKHIPMNKYFLKQQLAWVPFLGLACWALDMPFMKRYSRAYLLRHPERRGKDVETTRRSCEKFRLHPTTIVNFVEGSRFTQEKHQQTHSTFQNLLPPKAAGIAMALNVLGKQFDKLLNVTLCYPDNNRQPFFDMLSGKLTRIVVHVDLQPIADELHGDYINDKSFKRHFQQWLNSLWQEKDRLLTSLMSSQRQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A77</accession>
    <name>Q32A77_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator in 2-component system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cpxR</name>
        <name evidence="5" type="ordered locus">SDY_3834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001033722.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405269.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A77"/>
    <dbReference type="SMR" id="Q32A77"/>
    <dbReference type="STRING" id="300267.SDY_3834"/>
    <dbReference type="EnsemblBacteria" id="ABB63778">
        <property type="protein sequence ID" value="ABB63778"/>
        <property type="gene ID" value="SDY_3834"/>
    </dbReference>
    <dbReference type="GeneID" id="67417576"/>
    <dbReference type="KEGG" id="sdy:SDY_3834"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4528"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_6"/>
    <dbReference type="OMA" id="LAEVWDW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="232" mass="26312" checksum="667FC2B246082F46" modified="2005-12-06" version="1">MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDSIDLLLLDVMMPKKNGIDTLKALRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNGSPTLEVDALVLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A86</accession>
    <name>Q32A86_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yiiR</name>
        <name evidence="2" type="ordered locus">SDY_3824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000155256.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405260.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A86"/>
    <dbReference type="STRING" id="300267.SDY_3824"/>
    <dbReference type="EnsemblBacteria" id="ABB63769">
        <property type="protein sequence ID" value="ABB63769"/>
        <property type="gene ID" value="SDY_3824"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3824"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4516"/>
    <dbReference type="HOGENOM" id="CLU_093674_6_0_6"/>
    <dbReference type="OMA" id="KRWHDRN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008523">
        <property type="entry name" value="DUF805"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34980">
        <property type="entry name" value="PTHR34980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05656">
        <property type="entry name" value="DUF805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="143" mass="16141" checksum="02ABC9D9E2D91BFC" modified="2005-12-06" version="1">MTIQQWLFSFKGRIGRRDFWIWIGLWFAGMLVLFSLAGKNLLDIQTAAFCLVCLLWPTAAVTVKRLHDRGRSGAWAFLMIVAWMLLAGNWAILPGVWQWAVGRFVPTLILVMMLIDLGAFVGTQGENKYGKDTQDVKYGDASN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AB5</accession>
    <name>ARLY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate lyase</fullName>
            <shortName evidence="1">ASAL</shortName>
            <ecNumber evidence="1">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argH</name>
        <name type="ordered locus">SDY_3795</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001230102.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405231.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AB5"/>
    <dbReference type="SMR" id="Q32AB5"/>
    <dbReference type="STRING" id="300267.SDY_3795"/>
    <dbReference type="EnsemblBacteria" id="ABB63740">
        <property type="protein sequence ID" value="ABB63740"/>
        <property type="gene ID" value="SDY_3795"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3795"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4484"/>
    <dbReference type="HOGENOM" id="CLU_027272_2_3_6"/>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000240769" description="Argininosuccinate lyase">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <sequence length="457" mass="50285" checksum="8E78BB7B81D59A86" modified="2005-12-06" version="1">MALWGGRFTQAADQRFKQFNDSLRFDYRLAEQDIVGSVAWSKALVTVGVLTAEEQAQLEEALNVLLEDVRARPQQILESDAEDIHSWVEGKLIDKVGQLGKKLHTGRSRNDQVATDLKLWCKDTVSELLTANRQLQSVLVETAQNNQDAVMPGYTHLQRAQPVTFAHWCLAYVEMLARDESRLQDALKRLDVSPLGCGALAGTAYEIDREQLAGWLGFASATRNSLDSVSDRDHVLELLSAAAIGMVHLSRFAEDLIFFNTGEAGFVELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLHMAALVLDGIQVKRPRCQEAAQQGYANATELADYLVAKGVPFREAHHIVGEAVVEAIRQGKPLEDLPLDELQKFSPVIGEDVYPILSLQSCLDKRAAKGGVSPQQVAQAIAFAQARLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AE5</accession>
    <name>TRMA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA/tmRNA (uracil-C(5))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
            <ecNumber evidence="1">2.1.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m5U54)-methyltransferase</fullName>
            <shortName evidence="1">RUMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tmRNA (uracil(341)-C(5))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmA</name>
        <name type="ordered locus">SDY_3763</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + uridine(54) in tRNA = 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + uridine(341) in tmRNA = 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43612"/>
            <dbReference type="Rhea" id="RHEA-COMP:10630"/>
            <dbReference type="Rhea" id="RHEA-COMP:10631"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EC" id="2.1.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000187007.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405201.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AE5"/>
    <dbReference type="SMR" id="Q32AE5"/>
    <dbReference type="STRING" id="300267.SDY_3763"/>
    <dbReference type="EnsemblBacteria" id="ABB63710">
        <property type="protein sequence ID" value="ABB63710"/>
        <property type="gene ID" value="SDY_3763"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3763"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4450"/>
    <dbReference type="HOGENOM" id="CLU_043022_0_0_6"/>
    <dbReference type="OMA" id="DHMESGV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01011">
        <property type="entry name" value="RNA_methyltr_TrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011869">
        <property type="entry name" value="TrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47790">
        <property type="entry name" value="PTHR47790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02143">
        <property type="entry name" value="trmA_only"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000281465" description="tRNA/tmRNA (uracil-C(5))-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01011"/>
        </source>
    </evidence>
    <sequence length="366" mass="41890" checksum="4CE0CAECEC3C18F1" modified="2005-12-06" version="1">MTPEHLPTEQYEAQLAEKVVRLQSMMAPFSDLVPEVFRSPVSHYRMRAEFRIWHDGDDLYHIIFDQQTKSRIRVDSFPAASELINQLMTAMIAGVRNNPVLRHKLFQIDYLTTLSNQAVVSLLYHKKLDDEWRQEAEALRDALRAQNLNVHLIGRATKTKIALDQDYIDERLPVAGKEMIYRQVENSFTQPNAAMNIQMLEWALDVTKGSKGDLLELYCGNGNFSLALAHNFDRVLATEIAKPSVAAAQYNIAANHIDNVQIIRMAAEEFTQAMNGVREFNRLQGIDLKSYQCETIFVDPPRSGLDSETEKMVQAYPRILYISCNPETLCKNLETLSQTHKVERLALFDQFPYTHHMECGVLLTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AL9</accession>
    <name>Q32AL9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator affecting transcription of ompC and ompF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ompR</name>
        <name evidence="6" type="ordered locus">SDY_3671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001157751.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405127.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AL9"/>
    <dbReference type="SMR" id="Q32AL9"/>
    <dbReference type="STRING" id="300267.SDY_3671"/>
    <dbReference type="EnsemblBacteria" id="ABB63636">
        <property type="protein sequence ID" value="ABB63636"/>
        <property type="gene ID" value="SDY_3671"/>
    </dbReference>
    <dbReference type="GeneID" id="8912757"/>
    <dbReference type="KEGG" id="sdy:SDY_3671"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4356"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_6"/>
    <dbReference type="OMA" id="NIHGEGF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="239" mass="27354" checksum="823CA7720E9A1D2A" modified="2005-12-06" version="1">MQENYKILVVDDDMRLRALLERYLTEQGFQVRSVANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQSNPMPIIMVTAKGEEVDRIVGLEIGADDYIPKPFNPRELLARIRAVLRRQANELPGAPSQEEAVIAFGKFKLNLGTREMFREDEPMPLTSGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AP6</accession>
    <name>Q32AP6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphotransferase system enzyme subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001161552.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405100.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AP6"/>
    <dbReference type="STRING" id="300267.SDY_3641"/>
    <dbReference type="EnsemblBacteria" id="ABB63609">
        <property type="protein sequence ID" value="ABB63609"/>
        <property type="gene ID" value="SDY_3641"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3641"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4323"/>
    <dbReference type="HOGENOM" id="CLU_072531_6_0_6"/>
    <dbReference type="OMA" id="HAQLEML"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="157" mass="17499" checksum="33C5667DE96E3D63" modified="2005-12-06" version="1">MQGIHFQENYIQRLPAGLSVEQIIRQLAQPLVAAELVVPDFADHVLKREATYPTGLPTEPPCIAIPHTDHKHVRHNAIAVGILPEPVEFADMGGDPDPVPVRVIFLLALSESNKQLNALGWIMEMIQDTPFMQALLAMETTEIHTVILNKMKERGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AQ3</accession>
    <name>Q32AQ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport of nickel membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nikC</name>
        <name evidence="8" type="ordered locus">SDY_3633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001008803.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405093.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AQ3"/>
    <dbReference type="STRING" id="300267.SDY_3633"/>
    <dbReference type="EnsemblBacteria" id="ABB63602">
        <property type="protein sequence ID" value="ABB63602"/>
        <property type="gene ID" value="SDY_3633"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3633"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4312"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_6"/>
    <dbReference type="OMA" id="TDWFLVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014157">
        <property type="entry name" value="Nickel_NikC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02790">
        <property type="entry name" value="nickel_nikC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="67"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="277" mass="30361" checksum="24399567818630C3" modified="2005-12-06" version="1">MNFFISSRWSVRLALIIIALLALIALTSQWWLPYDPQAIDLPSRLLSPNAQHWLGTDHLGRDIFSRLMAATRVSLGSVMACLLLVLTLGLVIGGSAGLIGGRVDQATMRVADMFMTFPTSILSFFMVGVLGTGLTNVIIAIALSHWAWYARMVRSLVISLRQREFVLASRLSGAGHVRVFVDHLAGAVIPSLLVLATLDIGHMMLHVAGMSFLGLGVTAPTAEWGVMINDARQYIWTQPLQMFWPGLALFISVMAFNLVGDALRDHLDPHLVTEHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AV7</accession>
    <name>Q32AV7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glgP</name>
        <name evidence="11" type="ordered locus">SDY_3574</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000993449.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405039.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AV7"/>
    <dbReference type="SMR" id="Q32AV7"/>
    <dbReference type="STRING" id="300267.SDY_3574"/>
    <dbReference type="CAZy" id="GT35">
        <property type="family name" value="Glycosyltransferase Family 35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63548">
        <property type="protein sequence ID" value="ABB63548"/>
        <property type="gene ID" value="SDY_3574"/>
    </dbReference>
    <dbReference type="GeneID" id="66672688"/>
    <dbReference type="KEGG" id="sdy:SDY_3574"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4245"/>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_6"/>
    <dbReference type="OMA" id="KHKRTFT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="815" mass="93173" checksum="B8046B91D8D7B468" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B12</accession>
    <name>Q32B12_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yheT</name>
        <name evidence="3" type="ordered locus">SDY_3515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000057381.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404984.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B12"/>
    <dbReference type="STRING" id="300267.SDY_3515"/>
    <dbReference type="ESTHER" id="shifl-YHET">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="MEROPS" id="S33.A46"/>
    <dbReference type="EnsemblBacteria" id="ABB63493">
        <property type="protein sequence ID" value="ABB63493"/>
        <property type="gene ID" value="SDY_3515"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3515"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4169"/>
    <dbReference type="HOGENOM" id="CLU_032487_0_0_6"/>
    <dbReference type="OMA" id="RNDPFVP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="73"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="340" mass="38467" checksum="70D71D7EA7880D97" modified="2005-12-06" version="1">MAQITTTDANEFSSSAEFTPMRGFSNCHLQTMLPRLFRRKVKFTPYWQRLELPDGDFVDLAWSEAPAQARHKPRLVVFHGLEGSLNSPYAHGLVEAAQKRGWLGVVMHFRGCSGEPNRMHRIYHSGETEDASWFLRWLQREFGHAPTAAVGYSLGGNMLACLLAKEGNDLPVDAAVIVSAPFMLEACSYHMEKGFSRVYQRYLLNLLKANAARKLAAYPGTLPINLAQLKSVRRIREFDDLITARIHGYADAIDYYRQCSAMPMLNRIAKPTLIIHAKDDPFMNHQVIPKPESLPPQVEYQLTEHGGHVGFIGGTLLHPQMWLESRIPDWLTTYLEAKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B74</accession>
    <name>Q32B74_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acrF_1</name>
        <name evidence="7" type="ordered locus">SDY_3443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cell inner membrane</location>
            <topology evidence="2 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B74"/>
    <dbReference type="STRING" id="300267.SDY_3443"/>
    <dbReference type="EnsemblBacteria" id="ABB63431">
        <property type="protein sequence ID" value="ABB63431"/>
        <property type="gene ID" value="SDY_3443"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3443"/>
    <dbReference type="HOGENOM" id="CLU_002755_2_7_6"/>
    <dbReference type="OMA" id="MAFVGQM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="569" mass="61513" checksum="95C6CCE596343D4E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B81</accession>
    <name>Q32B81_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdT</name>
        <name evidence="2" type="ordered locus">SDY_3434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000381170.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404915.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B81"/>
    <dbReference type="STRING" id="300267.SDY_3434"/>
    <dbReference type="EnsemblBacteria" id="ABB63424">
        <property type="protein sequence ID" value="ABB63424"/>
        <property type="gene ID" value="SDY_3434"/>
    </dbReference>
    <dbReference type="GeneID" id="67415910"/>
    <dbReference type="KEGG" id="sdy:SDY_3434"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4090"/>
    <dbReference type="HOGENOM" id="CLU_166678_1_0_6"/>
    <dbReference type="OMA" id="WFELACL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010398">
        <property type="entry name" value="DUF997"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39174">
        <property type="entry name" value="PTHR39174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06196">
        <property type="entry name" value="DUF997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="80" mass="9108" checksum="4AD9D6B8E2AB93DF" modified="2005-12-06" version="1">MDTRFVQAHKEARWALGLTLLYLAVWLVAAYLPGVAPGFTGFPRWFEMACILTPLLFIGLCWAMVKFIYRDIPLEDDDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B95</accession>
    <name>Q32B95_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CsrA inhibitory activity suppressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tldD</name>
        <name evidence="7" type="ordered locus">SDY_3420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000055913.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404901.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B95"/>
    <dbReference type="STRING" id="300267.SDY_3420"/>
    <dbReference type="EnsemblBacteria" id="ABB63410">
        <property type="protein sequence ID" value="ABB63410"/>
        <property type="gene ID" value="SDY_3420"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3420"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4078"/>
    <dbReference type="HOGENOM" id="CLU_026425_1_0_6"/>
    <dbReference type="OMA" id="TDFWGSM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="4">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="6">
        <location>
            <begin position="125"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="5">
        <location>
            <begin position="246"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="481" mass="51332" checksum="33C5408C0405FED0" modified="2005-12-06" version="1">MSLNLVSEQLLAANGLKHQDLFAILGQLAERRLDYGDLYFQSSYHESWVLEDRIIKDGSYNIDQGVGVRAISGEKTGFAYADQISLLALEQSAQAARTIVRDSGDGKVQTLGAVEHSPLYTSVDPLQSMSREEKLDILRRVDKVAREADKRVQEVTASLSGVYELILVAATDGTLAADVRPLVRLSVSVLVEEDGKRERGASGGGGRFGYEFFLADLDGEVRADAWAKEAVRMALVNLSAVAAPAGTMPVVLGAGWPGVLLHEAVGHGLEGDFNRRGTSVFSGQVGELVASELCTVVDDGTMVDRRGSVAIDDEGTPGQYNVLIENGILKGYMQDKLNARLMGVTPTGNGRRESYAHLPMPRMTNTYMLPGKSTPQEIIESVEYGIYAPNFGGGQVDITSGKFVFSTSEAYLIENGKVTKPVKGATLIGSGIETMQQISMVGNDLKLDNGVGVCGKEGQSLPVGVGQPTLKVDNLTVGGTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BG9</accession>
    <name>PNP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polynucleotide phosphorylase</fullName>
            <shortName evidence="1">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pnp</name>
        <name type="ordered locus">SDY_3343</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63336" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63336.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018804.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404827.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BG9"/>
    <dbReference type="SMR" id="Q32BG9"/>
    <dbReference type="STRING" id="300267.SDY_3343"/>
    <dbReference type="EnsemblBacteria" id="ABB63336">
        <property type="protein sequence ID" value="ABB63336"/>
        <property type="gene ID" value="SDY_3343"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3343"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3997"/>
    <dbReference type="HOGENOM" id="CLU_004217_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000329849" description="Polyribonucleotide nucleotidyltransferase">
        <location>
            <begin position="1"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="553"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="622"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="711" mass="77069" checksum="79F6BCFBD0F43124" modified="2008-04-29" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BQ3</accession>
    <name>TSAD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="1">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsaD</name>
        <name type="synonym">gcp</name>
        <name type="ordered locus">SDY_3248</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001264352.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404743.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BQ3"/>
    <dbReference type="SMR" id="Q32BQ3"/>
    <dbReference type="STRING" id="300267.SDY_3248"/>
    <dbReference type="EnsemblBacteria" id="ABB63252">
        <property type="protein sequence ID" value="ABB63252"/>
        <property type="gene ID" value="SDY_3248"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3248"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3882"/>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_6"/>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000303538" description="tRNA N6-adenosine threonylcarbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <sequence length="337" mass="36008" checksum="AD676E3B635EC637" modified="2005-12-06" version="1">MRVLGIETSCDETGIAIYDDEKGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQAALKESGLTAKDIDAVAYTAGPGLVGALLVGATVGRSLAFAWDVPAIPVHHMEGHLLAPMLEDNPPEFPFVALLVSGGHTQLISVTGIGQYELLGESIDDAAGEAFDKTAKLLGLDYPGGPLLSKMAAQGTAGRFVFPRPMTDRPGLDFSFSGLKTFAANTIRDNGTDDQTRADIARAFEDAVVDTLMIKCKRALDQTGFKRLVMAGGVSANRTLRAKLAEMMKKRRGEVFYARPEFCTDNGAMIAYAGMVRFKAGATADLGVSVRPRWPLAELPAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C08</accession>
    <name>YQGB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein YqgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">yqgB</name>
        <name type="ordered locus">SDY_3133</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgB family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63147" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63147.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001297406.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404638.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C08"/>
    <dbReference type="EnsemblBacteria" id="ABB63147">
        <property type="protein sequence ID" value="ABB63147"/>
        <property type="gene ID" value="SDY_3133"/>
    </dbReference>
    <dbReference type="GeneID" id="66673179"/>
    <dbReference type="KEGG" id="sdy:SDY_3133"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3742"/>
    <dbReference type="HOGENOM" id="CLU_216465_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020196">
        <property type="entry name" value="Uncharacterised_YqgB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11036">
        <property type="entry name" value="YqgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000294098" description="Uncharacterized protein YqgB">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="43" mass="4859" checksum="87374692C56EAA07" modified="2007-07-10" version="2">MKKKPVAQLERQHSLLENPCAYGLLSQFQAAIVVNCFTLNKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CB9</accession>
    <name>Q32CB9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-1,2-propanediol oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fucO</name>
        <name evidence="3" type="ordered locus">SDY_3016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404527.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CB9"/>
    <dbReference type="STRING" id="300267.SDY_3016"/>
    <dbReference type="EnsemblBacteria" id="ABB63036">
        <property type="protein sequence ID" value="ABB63036"/>
        <property type="gene ID" value="SDY_3016"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3016"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3620"/>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_6"/>
    <dbReference type="OMA" id="PGELMDY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013460">
        <property type="entry name" value="Lactal_redase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02638">
        <property type="entry name" value="lactal_redase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="11"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="383" mass="40664" checksum="82D9D866092C7697" modified="2005-12-06" version="1">MMANRMILNETAWFGRGAVGALTDEVKRRGYQKALIVTDKTLVQCGVVAKVTDKMDAAGLAWAIYDGVVPNPTITVVKEGLGVFQNSGADYLIAIGGGSPQDTCKAIGIISNNPEFADVRSLEGLSPTNKPSVPILAIPTTAGTAAEVTINYVLTDEEKRRKFVCVDPHDIPQVAFIDADMMDGMPPALKAATGVDALTHAIEGYITRGAWALTDALHIKAIEIIAGALRGSVAGDKDAGEEMALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRYNADFTGEKYRDIARVMGVKVEGMSLEEARNAAVEAVFALNRDVGIPPHLRDVGVRKEDIPALAQAALDDVCTGGNPREATLEDIVELYRTAW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CI6</accession>
    <name>SURE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5'/3'-nucleotidase SurE</fullName>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
            <ecNumber evidence="1">3.1.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exopolyphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.11</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">surE</name>
        <name type="ordered locus">SDY_2943</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10144"/>
            <dbReference type="ChEBI" id="CHEBI:13197"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.1.3.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21528"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14279"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EC" id="3.1.3.6" evidence="1"/>
    <dbReference type="EC" id="3.6.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019613.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404460.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CI6"/>
    <dbReference type="SMR" id="Q32CI6"/>
    <dbReference type="STRING" id="300267.SDY_2943"/>
    <dbReference type="PRIDE" id="Q32CI6"/>
    <dbReference type="EnsemblBacteria" id="ABB62969">
        <property type="protein sequence ID" value="ABB62969"/>
        <property type="gene ID" value="SDY_2943"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2943"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3535"/>
    <dbReference type="HOGENOM" id="CLU_045192_1_2_6"/>
    <dbReference type="OMA" id="DCVHIAL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000235650" description="5'/3'-nucleotidase SurE">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <sequence length="253" mass="26940" checksum="847309C8950E7008" modified="2005-12-06" version="1">MRILLSNDDGVHAPGIQTLAKALREFADVQVVAPDRNRSGASNSLTLESSLRTFTFENGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHFGFPALAVSLDGHNHYDTAAAVTCSILRALCEEPLRTGRILNINVPDLPLDQIKGIRVTRCGTRHPADQVIPQQDPRGNTLYWIGPPGGKCDAGPGTDFAAVDEGYVSITPLRVDLTAHSAQDVVSDWLNSVGVGTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CJ0</accession>
    <name>Q32CJ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001208063.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404456.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CJ0"/>
    <dbReference type="STRING" id="300267.SDY_2939"/>
    <dbReference type="EnsemblBacteria" id="ABB62965">
        <property type="protein sequence ID" value="ABB62965"/>
        <property type="gene ID" value="SDY_2939"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2939"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3531"/>
    <dbReference type="HOGENOM" id="CLU_083287_4_0_6"/>
    <dbReference type="OMA" id="WNTMVSE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="15407" checksum="D7024FC0F29D2ABF" modified="2005-12-06" version="1">MALRNKAFHQLRQLFQQHTARWQHELPDLTKPQYAVMRAIADKPGIEQVALIEAAVSTKATLAEMLARMENRGLVRREHDAADKRRRFVWLTAEGEKILAAAIPIGDSVDEEFLGRLSAEEQGLFVQLVRKMMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CR5</accession>
    <name>Q32CR5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport permease protein of gamma-aminobutyrate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gabP</name>
        <name evidence="8" type="ordered locus">SDY_2853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001301367.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404381.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CR5"/>
    <dbReference type="SMR" id="Q32CR5"/>
    <dbReference type="STRING" id="300267.SDY_2853"/>
    <dbReference type="EnsemblBacteria" id="ABB62890">
        <property type="protein sequence ID" value="ABB62890"/>
        <property type="gene ID" value="SDY_2853"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2853"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3428"/>
    <dbReference type="HOGENOM" id="CLU_007946_9_3_6"/>
    <dbReference type="OMA" id="WEGGVHL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015185">
        <property type="term" value="F:gamma-aminobutyric acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011265">
        <property type="entry name" value="GABA_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01773">
        <property type="entry name" value="GABAperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="18"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="466" mass="51066" checksum="8763D526C84AF0F9" modified="2005-12-06" version="1">MGQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFSTYADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSWVPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIFLGAVAISGFYPYADVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNSVIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSCLNSALYTASRMLYSLSRRGDAPAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRMWLYPWLTWLVIGFITFVLVVMLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CU1</accession>
    <name>Q32CU1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yfiK</name>
        <name evidence="6" type="ordered locus">SDY_2821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404355.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CU1"/>
    <dbReference type="STRING" id="300267.SDY_2821"/>
    <dbReference type="EnsemblBacteria" id="ABB62864">
        <property type="protein sequence ID" value="ABB62864"/>
        <property type="gene ID" value="SDY_2821"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2821"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3398"/>
    <dbReference type="HOGENOM" id="CLU_079569_1_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="129" mass="14246" checksum="860F0307FBE205A1" modified="2005-12-06" version="1">MVVSAIASTPHLLSWAGAAYIVWLAWKIATSPTKEDGLQTKPISFWASFALQFVNVKIILYGVTALSTFVLPQTQALSWIVGVSVLLAMIGTFGNVCWALAGHLFQRLFRQLNIVLALLLIYCAVRIFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DL6</accession>
    <name>PDXB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Erythronate-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.290</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxB</name>
        <name type="ordered locus">SDY_2519</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18829"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="ChEBI" id="CHEBI:58766"/>
            <dbReference type="EC" id="1.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.290" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000699138.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404080.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DL6"/>
    <dbReference type="SMR" id="Q32DL6"/>
    <dbReference type="STRING" id="300267.SDY_2519"/>
    <dbReference type="EnsemblBacteria" id="ABB62589">
        <property type="protein sequence ID" value="ABB62589"/>
        <property type="gene ID" value="SDY_2519"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2519"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3034"/>
    <dbReference type="HOGENOM" id="CLU_019796_4_0_6"/>
    <dbReference type="OMA" id="SAPGCNA"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033711">
        <property type="term" value="F:4-phosphoerythronate dehydrogenase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12158">
        <property type="entry name" value="ErythrP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01825">
        <property type="entry name" value="PdxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020921">
        <property type="entry name" value="Erythronate-4-P_DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024531">
        <property type="entry name" value="Erythronate-4-P_DHase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038251">
        <property type="entry name" value="PdxB_dimer_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11890">
        <property type="entry name" value="DUF3410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000297474" description="Erythronate-4-phosphate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01825"/>
        </source>
    </evidence>
    <sequence length="378" mass="41338" checksum="BFE6A5776D3A2B1E" modified="2005-12-06" version="1">MKILVDENMPYARDLFSRLGEVTAVPGRPIPVAQLADADALMVRSVTKVNESLLAGKPIKFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSSLLMLAERDGFSLHERTVGIVGVGNVGRRLQARLEALGIKTLLCDPPRADRGDEGDFRSLDELVQRADILTFHTPLFKDGPYKTLHLADEKLIRSLKPGAILINACRGAVVDNTALLTCLNEGQKLSVVLDVWEGEPELNVELLTKVDIGTPHIAGYTLEGKARGTTQVFEAYSKFIGHKQHVALDTLLPAPEFGRITLHGPLDQPTLKRLVHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVICDDASAASLLCKLGFNAVHHPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DM1</accession>
    <name>Q32DM1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Dihydrofolate synthase/folylpolyglutamate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">folC</name>
        <name evidence="14" type="ordered locus">SDY_2514</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 11">Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:51912"/>
            <dbReference type="Rhea" id="RHEA-COMP:13257"/>
            <dbReference type="Rhea" id="RHEA-COMP:13258"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:136572"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:51904"/>
            <dbReference type="Rhea" id="RHEA-COMP:13088"/>
            <dbReference type="Rhea" id="RHEA-COMP:14300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:134413"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000584604.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404075.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DM1"/>
    <dbReference type="STRING" id="300267.SDY_2514"/>
    <dbReference type="EnsemblBacteria" id="ABB62584">
        <property type="protein sequence ID" value="ABB62584"/>
        <property type="gene ID" value="SDY_2514"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2514"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3029"/>
    <dbReference type="HOGENOM" id="CLU_015869_1_0_6"/>
    <dbReference type="OMA" id="YFEMGTL"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="13">
        <location>
            <begin position="54"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="12">
        <location>
            <begin position="287"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00002714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB62584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="422" mass="45379" checksum="59EDB4F010470DE5" modified="2005-12-06" version="1">MIIKRTPQASSPLASWLSYLENLHSKTIDLGLERVSQVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLGVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DW0</accession>
    <name>Q32DW0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403986.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DW0"/>
    <dbReference type="STRING" id="300267.SDY_2422"/>
    <dbReference type="EnsemblBacteria" id="ABB62495">
        <property type="protein sequence ID" value="ABB62495"/>
        <property type="gene ID" value="SDY_2422"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2422"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2920"/>
    <dbReference type="HOGENOM" id="CLU_1668211_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018671">
        <property type="entry name" value="DUF2138"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09909">
        <property type="entry name" value="DUF2138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="158" mass="17627" checksum="E7ABFFB24961BF8A" modified="2005-12-06" version="1">MAVPVKNGWLYTRNVAMSGEKKAKGWRFYGLVGFGAIVLLSAGVWALQNKTLLFSLDDTLVNNALQTLNKTRPAMVDVIPTDGIVPLYINPQGVAKLLRNETLTSLPKNLEPVFYNAAQTLLMPKLDVLSQQPRYVMKLAQMEPGAAWQWLTITWQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DZ3</accession>
    <name>Q32DZ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane water channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aqpZ</name>
        <name evidence="8" type="ordered locus">SDY_2388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000488717.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403953.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DZ3"/>
    <dbReference type="STRING" id="300267.SDY_2388"/>
    <dbReference type="EnsemblBacteria" id="ABB62462">
        <property type="protein sequence ID" value="ABB62462"/>
        <property type="gene ID" value="SDY_2388"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2388"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2881"/>
    <dbReference type="HOGENOM" id="CLU_020019_3_2_6"/>
    <dbReference type="OMA" id="IFKALMY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="PTHR45724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="225" mass="22985" checksum="6C606D34D22202D2" modified="2005-12-06" version="1">MFRKLAAECFGTFWLVFGGCGSAVLAAGFPELGIGFAGVALAFGLTVLTMAFAVGHISGGHFNPAVTIGLWAGGRFPAKEVVGYVIAQVVGGIVAAALLYLIASGKTGFDAAASGFASNGYGEHSPGGYSMLSALVVELVLSAGFLLVIHGATDKFAPAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTAVAIFQGSGDWPPPARSLRQWLYMALHMKGAQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E02</accession>
    <name>Q32E02_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding component of serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">clpA</name>
        <name evidence="10" type="ordered locus">SDY_2379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000934044.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403944.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E02"/>
    <dbReference type="STRING" id="300267.SDY_2379"/>
    <dbReference type="EnsemblBacteria" id="ABB62453">
        <property type="protein sequence ID" value="ABB62453"/>
        <property type="gene ID" value="SDY_2379"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2379"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2872"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_6"/>
    <dbReference type="OMA" id="GRVIQEH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013461">
        <property type="entry name" value="ClpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02639">
        <property type="entry name" value="ClpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="758" mass="84210" checksum="E296A2EB64A9F7D9" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E43</accession>
    <name>Q32E43_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromosome partition protein MukE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mukE</name>
        <name evidence="8" type="ordered locus">SDY_2335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts, and probably forms a ternary complex, with MukF and MukB. The complex formation is stimulated by calcium or magnesium.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Nucleoid</location>
        </subcellularLocation>
        <text evidence="6">Restricted to the nucleoid region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MukE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403903.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E43"/>
    <dbReference type="SMR" id="Q32E43"/>
    <dbReference type="STRING" id="300267.SDY_2335"/>
    <dbReference type="EnsemblBacteria" id="ABB62412">
        <property type="protein sequence ID" value="ABB62412"/>
        <property type="gene ID" value="SDY_2335"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2335"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2819"/>
    <dbReference type="HOGENOM" id="CLU_1146408_0_0_6"/>
    <dbReference type="OMA" id="FLMDYQE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01802">
        <property type="entry name" value="MukE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042037">
        <property type="entry name" value="MukE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042038">
        <property type="entry name" value="MukE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007385">
        <property type="entry name" value="Scp_MukE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04288">
        <property type="entry name" value="MukE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="225" mass="25984" checksum="DE845E59ECC5D229" modified="2005-12-06" version="1">MPVKLAQALANPLFPALDSALRSGRHIGLDELDNHAFLMDFQEYLEEFYARYNVELIRAPEGFFYLRPRSTTLIPRSVLSELDMMVGKILCYLYLSPERLANEGIFTQQELYDELLTLADEAKLLKLVNNRSTGSDVDRQKLQEKVRSSLNRLRRLGMVWFMGHDSSKFRITESVFRFGADVRAGDDPREAQRRLIRDGEAMPIENHLQLNDETEENQPDSGEEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E86</accession>
    <name>TRHO_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine(34) hydroxylase</fullName>
            <ecNumber evidence="1">1.14.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA hydroxylation protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trhO</name>
        <name type="synonym">yceA</name>
        <name type="ordered locus">SDY_2292</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:64224"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrhO family.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378794.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403860.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E86"/>
    <dbReference type="SMR" id="Q32E86"/>
    <dbReference type="STRING" id="300267.SDY_2292"/>
    <dbReference type="EnsemblBacteria" id="ABB62369">
        <property type="protein sequence ID" value="ABB62369"/>
        <property type="gene ID" value="SDY_2292"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2292"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2768"/>
    <dbReference type="HOGENOM" id="CLU_038878_1_1_6"/>
    <dbReference type="OMA" id="CDTHTNC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00469">
        <property type="entry name" value="TrhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000242942" description="tRNA uridine(34) hydroxylase">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="146"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00469"/>
        </source>
    </evidence>
    <sequence length="350" mass="39751" checksum="181D32AE95C3E56D" modified="2005-12-06" version="1">MPVLHNRISNDALKAKMLAESEPRTTISFYKYFHIADPKVTRAALYQLFTALNVFGRVYLAHEGMNAQISVPASNVETFRAQLYAFDPALEGLRLNIALDDDGKSFWVLRMKVRDRIVADGIDDPHFDASNVGEYLQAAEVNAMLDDPDALFIDMRNHYEYEVGHFENALEIPADTFREQLPKAVEMMQAHKDKKIVMYCTGGIRCEKASAWMKHNGFNKVWHIEGGIIEYARKAREQGLPVRFIGKNFVFDERMGERISDEIIAHCHQCGAPCDSHTNCKNDGCHLLFIQCPVCAEKYKGCCSEICCEESALPPEEQRRRRAGRENGNKIFNKSRGRLNTTLGIPEPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EA1</accession>
    <name>Q32EA1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thiD</name>
        <name evidence="5" type="ordered locus">SDY_2277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000822303.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403845.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EA1"/>
    <dbReference type="STRING" id="300267.SDY_2277"/>
    <dbReference type="EnsemblBacteria" id="ABB62354">
        <property type="protein sequence ID" value="ABB62354"/>
        <property type="gene ID" value="SDY_2277"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2277"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2750"/>
    <dbReference type="HOGENOM" id="CLU_020520_0_1_6"/>
    <dbReference type="OMA" id="DNRHTHG"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="4">
        <location>
            <begin position="13"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="266" mass="28664" checksum="8F95CEF2C05B8F0F" modified="2005-12-06" version="1">MKRINALTIASTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVMLAKSGDPLLSPSAVATLRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDDEQSPDWLFTREGEQRFTAPRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSSALAQADTLEVGHGIGPVHHFHAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EF1</accession>
    <name>Q32EF1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histidine biosynthesis bifunctional protein HisB</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Histidinol-phosphatase</fullName>
                <ecNumber evidence="11">3.1.3.15</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">Imidazoleglycerol-phosphate dehydratase</fullName>
                <shortName evidence="11">IGPD</shortName>
                <ecNumber evidence="11">4.2.1.19</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">hisB</name>
        <name evidence="12" type="ordered locus">SDY_2219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the N-terminal section; belongs to the histidinol-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="11"/>
    <dbReference type="EC" id="4.2.1.19" evidence="11"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EF1"/>
    <dbReference type="STRING" id="300267.SDY_2219"/>
    <dbReference type="EnsemblBacteria" id="ABB62304">
        <property type="protein sequence ID" value="ABB62304"/>
        <property type="gene ID" value="SDY_2219"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2219"/>
    <dbReference type="HOGENOM" id="CLU_044308_0_0_6"/>
    <dbReference type="OMA" id="PEDTFWP"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01022">
        <property type="entry name" value="Bifunc_HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020566">
        <property type="entry name" value="His_synth_bifunc_HisB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005954">
        <property type="entry name" value="HisB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01261">
        <property type="entry name" value="hisB_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Histidinol-phosphatase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Imidazoleglycerol-phosphate dehydratase" evidence="11">
        <location>
            <begin position="168"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="356" mass="40372" checksum="1B79A4D457CE05CE" modified="2005-12-06" version="1">MMSQKYLFIDRDGTLISEPPSDFQVDRFDKLAFEPGVIPELLKLQKAGYKLVMITNQDGLGTQSFPQADFDGPHNLMMQIFTSQGVQFDEVLICPHLPADECDCRKPKVKLVERYLAEQAMDRANSYVIGDRATDIQLAENMGINGLRYDCEILSWPMIGEQLTKRDRYAHVVRNTKETQIDVRVWLDREGGSKINTGVGFFDHMLDQIATHGGFRMEINVKGDLYIDDHHTVEDTGLALGEALKMALGDKRGICRFGFVLPMDECLARCALDISGRPHLEYKAEFTYQRVGDLSTEMIEHFFRSLSYTMGVTLHLKTKGKNDHHRVESLFKAFGRTLRQAIRVEGDTLPSSKGVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EF2</accession>
    <name>HIS5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="1">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ImGP synthase subunit HisH</fullName>
            <shortName evidence="1">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisH</name>
        <name type="ordered locus">SDY_2218</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001103560.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403794.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EF2"/>
    <dbReference type="SMR" id="Q32EF2"/>
    <dbReference type="STRING" id="300267.SDY_2218"/>
    <dbReference type="EnsemblBacteria" id="ABB62303">
        <property type="protein sequence ID" value="ABB62303"/>
        <property type="gene ID" value="SDY_2218"/>
    </dbReference>
    <dbReference type="GeneID" id="60668934"/>
    <dbReference type="KEGG" id="sdy:SDY_2218"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2682"/>
    <dbReference type="HOGENOM" id="CLU_071837_0_0_6"/>
    <dbReference type="OMA" id="WVYFVHS"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000231758" description="Imidazole glycerol phosphate synthase subunit HisH">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <sequence length="196" mass="21653" checksum="B75A500ECD50DDD0" modified="2005-12-06" version="1">MNVVILDTGCANLNSVKSAIARHGYEPKVSRDPDVVLLADKLFLPGVGTAQAAMDQVRERELFDLIKACTQPVLGICLGMQLLGRRSEESNGVDLLGIIDEDVPKMTDFGLPLPHMGWNRVYPQAGNRLFQGIEDGAYFYFVHSYAMPVNPWTIAQCNYGEPFTAAVQKDNFYGVQFHPERSGAAGAKLLKNFLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EF6</accession>
    <name>Q32EF6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulator of length of O-antigen component of lipopolysaccharide chains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">wzzB</name>
        <name evidence="8" type="ordered locus">SDY_2214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403790.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EF6"/>
    <dbReference type="STRING" id="300267.SDY_2214"/>
    <dbReference type="EnsemblBacteria" id="ABB62299">
        <property type="protein sequence ID" value="ABB62299"/>
        <property type="gene ID" value="SDY_2214"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2214"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2678"/>
    <dbReference type="HOGENOM" id="CLU_060925_1_1_6"/>
    <dbReference type="OMA" id="IIAKLWR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="35"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="344" mass="38507" checksum="3F0BFBA3364E16A1" modified="2005-12-06" version="1">MAIIAKLWRLKIISSVRVMMRVENNNVSGQNHDPEQIDLIDLLVQLWRGKMTIIISVIVAIALAIGYLAVAKEKWTSTAIVTQPDVGQIAGYNNAMNVIYGQATPKVSDLQETLIGRFSSAFSALAETLDNQEEPEKLTIEPSVKNQQLPLTVSYVGQTAEGAQMKLAQYIQQVDDKVNQELEKDLKDNIALGRKNLQDSLRTQEVVAQEQKDLRIRQIQEALQYANQAQVTKPQVQQTEDVTQDTLFLLGSEALESMIKHEATRPLVFSPSYYQTRQNLLDIENLKVDDLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALRNYNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EF8</accession>
    <name>Q32EF8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11 15">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="6 11 15">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">gnd</name>
        <name evidence="17" type="ordered locus">SDY_2212</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 15">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11 15">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 15">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="6 11 15"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_000043456.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403788.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
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    <dbReference type="AlphaFoldDB" id="Q32EF8"/>
    <dbReference type="STRING" id="300267.SDY_2212"/>
    <dbReference type="EnsemblBacteria" id="ABB62297">
        <property type="protein sequence ID" value="ABB62297"/>
        <property type="gene ID" value="SDY_2212"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2212"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2676"/>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_6"/>
    <dbReference type="OMA" id="VIMVKAG"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:NADP binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:D-gluconate metabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
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        <property type="project" value="UniProt"/>
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        <property type="term" value="P:pentose-phosphate shunt"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6PGD_dom2"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51735"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 11 15" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="16">
        <location>
            <begin position="179"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="13">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="13">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <begin position="74"/>
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        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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    <feature type="binding site" evidence="13 14">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="445"/>
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        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
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            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB62297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="468" mass="51499" checksum="C2A76D7FDC5BB130" modified="2005-12-06" version="1">MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELAQTFTEWNNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADDYQQALRDVVAYAVQNGIPVPTFAAAVAYYDSYRAAFLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EL4</accession>
    <name>Q32EL4_SHIDS</name>
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        <recommendedName>
            <fullName evidence="6">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yohC</name>
        <name evidence="7" type="ordered locus">SDY_2153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EL4"/>
    <dbReference type="STRING" id="300267.SDY_2153"/>
    <dbReference type="EnsemblBacteria" id="ABB62241">
        <property type="protein sequence ID" value="ABB62241"/>
        <property type="gene ID" value="SDY_2153"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2153"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2603"/>
    <dbReference type="HOGENOM" id="CLU_099801_0_0_6"/>
    <dbReference type="OMA" id="HPKEEWH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="13"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="203" mass="22495" checksum="DA8E0E450BC159EC" modified="2005-12-06" version="1">MNSQQGGGMSHVWGLFSHPDREMQVINRENETISHHYTHHVLLMAAIPVIFAFIGTTQIGWNFGDGTILKLSWFTGLALAVLFYGVMLAGVAVMGRVIWWMARNYPQRPSLAHCMVFAGYVATPLFLSGLVALYPLVWLCALVGTVALFYTGYLLYLGIPSFLNINKEEGLSFSSSTLAIGVLVLEVLLALTVILWGYGYRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ES7</accession>
    <name>Q32ES7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403669.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ES7"/>
    <dbReference type="EnsemblBacteria" id="ABB62178">
        <property type="protein sequence ID" value="ABB62178"/>
        <property type="gene ID" value="SDY_2087"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2087"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2509"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15352" checksum="E71E354E99B1D86B" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQWIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EU2</accession>
    <name>Q32EU2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hook-filament junction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">flgL</name>
        <name evidence="6" type="ordered locus">SDY_2068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022062.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EU2"/>
    <dbReference type="STRING" id="300267.SDY_2068"/>
    <dbReference type="EnsemblBacteria" id="ABB62163">
        <property type="protein sequence ID" value="ABB62163"/>
        <property type="gene ID" value="SDY_2068"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2068"/>
    <dbReference type="HOGENOM" id="CLU_024437_5_0_6"/>
    <dbReference type="OMA" id="MRVTQGM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="298" mass="31862" checksum="F1ADC168CD99D1B9" modified="2005-12-06" version="1">MRFSTQMMYQQNMRGITNSQAEWMKYGEQMSTGKRVVNPSDDPIAASQAVVLSQAQAQNSQYTLARTFATQKVSLEESVLSQVTTAIQNAQEKIVYASNGTLSDDDRASLATDIQGLRDQLLNLANTTDGNGRYIFAGYKTETAPFSEANGDYVGGTESIKQQVDASRSMVIGHTGDKIFDSITSNAVAEPDGSASETNLFAMLDSAIAALKTPVADSEADKETAAAALDKTNRGLKNSLNNVLTVRAELGTQLNELESLDSLASDRALGQTQQMSDLVDVDWNATISHAANGIAGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F06</accession>
    <name>Q32F06_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2000</name>
        <name evidence="3" type="ordered locus">SDY_2004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_2000"/>
    <dbReference type="EnsemblBacteria" id="ABB62095">
        <property type="protein sequence ID" value="ABB62095"/>
        <property type="gene ID" value="SDY_2000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62099">
        <property type="protein sequence ID" value="ABB62099"/>
        <property type="gene ID" value="SDY_2004"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2000"/>
    <dbReference type="KEGG" id="sdy:SDY_2004"/>
    <dbReference type="HOGENOM" id="CLU_027402_14_0_6"/>
    <dbReference type="OMA" id="LNESICK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="176" mass="20211" checksum="DDFB31C448B0417D" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRRQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F88</accession>
    <name>Q32F88_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 8">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SDY_1911</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F88"/>
    <dbReference type="STRING" id="300267.SDY_1911"/>
    <dbReference type="EnsemblBacteria" id="ABB62017">
        <property type="protein sequence ID" value="ABB62017"/>
        <property type="gene ID" value="SDY_1911"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1911"/>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_6"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="2"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="329" mass="36038" checksum="9FEA6A09F8F70C47" modified="2005-12-06" version="1">MFINARSAEELVFVRGTTEGINLVANSWGNSNVRVGDNIIISQMEHHANIVPWQMLCARVGAELRVIPLNPDGTLQLETLPTLFDEKTRLLAITHVSNVLGTENPLAEMITLAHQHGAKVLVDGAQAVMHHPVDVQALDCDFYVFSGHKLYGPTGIGILYVKEALLQEMPPWEGGGSMIATVSLSEGTTWTKAPWRFEAGTPNTGDIIGLGAALEYVSALGLNNIAEYEQNLMHYALSQLESVPDLTLYGPQNRLGVIAFNLGKHHAYDVGSFLDNYGIAVRTGHHCAMPLMAYYNVPAMCRASLAMYNTHEEVDRLVTGLQRIHRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FB6</accession>
    <name>Q32FB6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ydhO</name>
        <name evidence="5" type="ordered locus">SDY_1881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000101186.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403480.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FB6"/>
    <dbReference type="STRING" id="300267.SDY_1881"/>
    <dbReference type="EnsemblBacteria" id="ABB61989">
        <property type="protein sequence ID" value="ABB61989"/>
        <property type="gene ID" value="SDY_1881"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1881"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2263"/>
    <dbReference type="HOGENOM" id="CLU_016043_2_0_6"/>
    <dbReference type="OMA" id="ILYWGSA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221079" evidence="3">
        <location>
            <begin position="28"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="142"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="275" mass="30361" checksum="2CD49FE1ED8FC0E8" modified="2005-12-06" version="1">MARINRISITLCALLFTTLPLTPMAHASKQARESSATTHITKKADKKKSTATTKKTQKASQKTAKKAASKSTTKSKTASSVKKSSITASKNAKTRSKHTVNKTASASFTEKCTKRKGYKSHCVKVKNAASGTLADAHKAKVQKATKVAMNKLMQQIGKPYRWGGSSPRTGFDCSGLVYYAYKDLVKIRIPRTANEMYHLRDAAPIERSELKNGDLVFFRTQGRGTADHVGVYVGNGKFIQSPRTGQEIQITSLSEDYWQRHYVGARRVMTPKTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FC3</accession>
    <name>Q32FC3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001032921.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403473.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FC3"/>
    <dbReference type="STRING" id="300267.SDY_1872"/>
    <dbReference type="EnsemblBacteria" id="ABB61981">
        <property type="protein sequence ID" value="ABB61981"/>
        <property type="gene ID" value="SDY_1872"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1872"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2252"/>
    <dbReference type="HOGENOM" id="CLU_069356_28_1_6"/>
    <dbReference type="OMA" id="CAQTIYT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16925">
        <property type="entry name" value="TetR_C_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="199" mass="22278" checksum="2CAAFA48B40D5A7E" modified="2005-12-06" version="1">MNKHTEHDTREHLLAMGEQLCLQRGFTGMGLSELLKTAEVPKGSFYHYFRSKEAFGVAMLERHYAAYHQRLTELLQSGEGNYRDRILAYYQQTLNQFCQHGTISGCLTVKLSAEVYDLSEDMRSAMDKGARGVIALLSQALENGRDSHCLTFCGEPLQQAQVLYALWLGANLQAKISRNSEPLENALAHVKTIIATPAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FE6</accession>
    <name>RSXA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ion-translocating oxidoreductase complex subunit A</fullName>
            <ecNumber evidence="1">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Rsx electron transport complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsxA</name>
        <name type="ordered locus">SDY_1850</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000133193.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403450.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FE6"/>
    <dbReference type="SMR" id="Q32FE6"/>
    <dbReference type="STRING" id="300267.SDY_1850"/>
    <dbReference type="EnsemblBacteria" id="ABB61959">
        <property type="protein sequence ID" value="ABB61959"/>
        <property type="gene ID" value="SDY_1850"/>
    </dbReference>
    <dbReference type="GeneID" id="66674481"/>
    <dbReference type="KEGG" id="sdy:SDY_1850"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2229"/>
    <dbReference type="HOGENOM" id="CLU_095255_1_0_6"/>
    <dbReference type="OMA" id="CPFFGVS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00459">
        <property type="entry name" value="RsxA_RnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011293">
        <property type="entry name" value="Ion_transpt_RnfA/RsxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01943">
        <property type="entry name" value="rnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000013557" description="Ion-translocating oxidoreductase complex subunit A">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00459"/>
        </source>
    </evidence>
    <sequence length="193" mass="20898" checksum="525955B3760398D7" modified="2005-12-06" version="1">MTDYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAMGMGLATTFVMTLASICAWLIDTWILIPLNLIYLRTLAFILVIAVVVQFTEMVVRKTSPVLYRLLGIFLPLITTNCAVLGVALLNINLGHNFLQSALYGFSAAVGFSLVMVLFAAIRERLAVADVPAPFRGNAIALITAGLMSLAFMGFSGLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FI4</accession>
    <name>Q32FI4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase operon leader peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001386830.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61921">
        <property type="protein sequence ID" value="ABB61921"/>
        <property type="gene ID" value="SDY_1810"/>
    </dbReference>
    <dbReference type="GeneID" id="64728563"/>
    <dbReference type="GeneID" id="67514541"/>
    <dbReference type="KEGG" id="sdy:SDY_1810"/>
    <dbReference type="HOGENOM" id="CLU_222433_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="14" mass="1762" checksum="7D31C48E0060F0D4" modified="2005-12-06" version="1">MNAAIFRFFFYFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FK7</accession>
    <name>Q32FK7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403389.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FK7"/>
    <dbReference type="STRING" id="300267.SDY_1784"/>
    <dbReference type="EnsemblBacteria" id="ABB61898">
        <property type="protein sequence ID" value="ABB61898"/>
        <property type="gene ID" value="SDY_1784"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1784"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2152"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="257"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="377" mass="44168" checksum="46185CBB5BAC5276" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSVLIKDILFYLNNNYREKITLEQLSKKFRASVSYICHEFTKEYRISPINYVIQRRMTEAKWSLTNTELSQAEISWRVGYENVDHFAKLFLRHVGCSPSDYRRQFKNCFAEQEILSEFPQPVSLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FM6</accession>
    <name>Q32FM6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403370.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FM6"/>
    <dbReference type="EnsemblBacteria" id="ABB61879">
        <property type="protein sequence ID" value="ABB61879"/>
        <property type="gene ID" value="SDY_1762"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1762"/>
    <dbReference type="HOGENOM" id="CLU_3128707_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="55" mass="5927" checksum="C6ADF69E7B957D0F" modified="2005-12-06" version="1">MNQAIQMLASYPPSGKEKGYEAQPSGGVSAHYLHYDSDIHTPDPTNALRTAVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FU1</accession>
    <name>Q32FU1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FU1"/>
    <dbReference type="EnsemblBacteria" id="ABB61814">
        <property type="protein sequence ID" value="ABB61814"/>
        <property type="gene ID" value="SDY_1693"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1693"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="138" mass="16033" checksum="B3FC77B23112235D" modified="2005-12-06" version="1">MPVAHADVALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKHKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GE2</accession>
    <name>AROD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="1">3-dehydroquinase</shortName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type I DHQase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type I dehydroquinase</fullName>
            <shortName evidence="1">DHQ1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroD</name>
        <name type="ordered locus">SDY_1474</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000860167.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403104.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GE2"/>
    <dbReference type="SMR" id="Q32GE2"/>
    <dbReference type="STRING" id="300267.SDY_1474"/>
    <dbReference type="EnsemblBacteria" id="ABB61613">
        <property type="protein sequence ID" value="ABB61613"/>
        <property type="gene ID" value="SDY_1474"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1474"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1758"/>
    <dbReference type="HOGENOM" id="CLU_064444_0_0_6"/>
    <dbReference type="OMA" id="ATMAMGE"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00214">
        <property type="entry name" value="AroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018508">
        <property type="entry name" value="3-dehydroquinate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01028">
        <property type="entry name" value="DEHYDROQUINASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_1000043181" description="3-dehydroquinate dehydratase">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00214"/>
        </source>
    </evidence>
    <sequence length="252" mass="27520" checksum="FA5A534D5AB7FBBB" modified="2005-12-06" version="1">MKTVTVKDLVIGAGAPKIIVSLMAKDIARVKSEALAYRETDFDILEWRVDHFADLSNVESVMAAAKILRETMPEKPLLFTFRSAKEGGEQAISTEAYIALNRAAIDSGLVDMIDLELFTGDDQVKETVAYAHAHDVKVVMSNHDFHKTPEAEEIIARLRKMQSFDADIPKIALMPQSTSDVLTLLAATLEMQEQYADRPIITMSMAKTGVISRLAGEVFGSAATFGAVKKASAPGQISVNDLRTVLTILHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GE9</accession>
    <name>Q32GE9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YdbL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ydbL</name>
        <name evidence="1" type="ordered locus">SDY_1467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GE9"/>
    <dbReference type="STRING" id="300267.SDY_1467"/>
    <dbReference type="EnsemblBacteria" id="ABB61606">
        <property type="protein sequence ID" value="ABB61606"/>
        <property type="gene ID" value="SDY_1467"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1467"/>
    <dbReference type="HOGENOM" id="CLU_146585_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008309">
        <property type="entry name" value="UCP025560"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07027">
        <property type="entry name" value="DUF1318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="109" mass="12105" checksum="D548C5154871E23C" modified="2005-12-06" version="1">MSMKSSLKRIRTLKTCSKPVAIYFEVMMKRTLLIAVWAIGLMSDSAMALTLNEARSQGRVGETLNGYLVALQTDAETQALVKDINEARNHSYQQLAKQNNVSTVMPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GF9</accession>
    <name>Q32GF9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron transport protein, inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sitC</name>
        <name evidence="8" type="ordered locus">SDY_1455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001101728.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403087.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GF9"/>
    <dbReference type="STRING" id="300267.SDY_1455"/>
    <dbReference type="EnsemblBacteria" id="ABB61596">
        <property type="protein sequence ID" value="ABB61596"/>
        <property type="gene ID" value="SDY_1455"/>
    </dbReference>
    <dbReference type="GeneID" id="60668572"/>
    <dbReference type="KEGG" id="sdy:SDY_1455"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1733"/>
    <dbReference type="HOGENOM" id="CLU_028808_4_0_6"/>
    <dbReference type="OMA" id="GAWLSYY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="285" mass="30814" checksum="4F7F22AE72FE2D76" modified="2005-12-06" version="1">MNVLLEPFSYEYMLNAMWVSAMVGGLCAFLSCYLMLKGWSLIGDALSHSIVPGVAGAYMLGLPFSLGAFFSGGLAAGSMLFLNQRTRLKEDAIIGLIFSSFFGLGLFMVSLNPTSVNIQTIVLGNILAIDPADILQLTIIGILSIIVLFFKWKDLMVTFFDENHARAIGLHPGRLKILFFTLLSVSTVAALQTVGAFLVICLVVTPGATAWLLTDRFPRLLIIAVTIGSVTSFLGAWVSYFLDGATGGIIVVAQTLLFLLAFVFAPTHGLLANRRRAHKALEDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GN6</accession>
    <name>Q32GN6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_1374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell outer membrane</location>
            <topology evidence="1 7">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GN6"/>
    <dbReference type="STRING" id="300267.SDY_1374"/>
    <dbReference type="EnsemblBacteria" id="ABB61519">
        <property type="protein sequence ID" value="ABB61519"/>
        <property type="gene ID" value="SDY_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1374"/>
    <dbReference type="HOGENOM" id="CLU_012817_13_1_6"/>
    <dbReference type="OMA" id="NTGPHAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="275" mass="29818" checksum="9E13482E1DA608EF" modified="2005-12-06" version="1">MTSAENSLKIIQRQQQVGTAAATDVSEAMSVYQQARASVASYQTQVMQDKNALNLLAGTTLEENLLPGTLESLPEQMISLVPAGVSSDVLLRRPDIQEAEHNLKSANADIGAARANFFPTISLTASAGVGSDALSSLFSHGMQIWSFTPSVTLPLFTGGSNLAQLRYAEAQKRGLIATYEKTVQSAFKDVANALARRTTLEEQLDAQRQYVKAEQQTVDVGLRRYQTGVGDYLTVLTAQRSLWSAQQELLALQLTDFTNRITLWQSLGGGMSSLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GQ2</accession>
    <name>PYRF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">OMP decarboxylase</fullName>
            <shortName evidence="1">OMPDCase</shortName>
            <shortName evidence="1">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrF</name>
        <name type="ordered locus">SDY_1357</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OMP decarboxylase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000176280.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402994.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GQ2"/>
    <dbReference type="SMR" id="Q32GQ2"/>
    <dbReference type="STRING" id="300267.SDY_1357"/>
    <dbReference type="EnsemblBacteria" id="ABB61503">
        <property type="protein sequence ID" value="ABB61503"/>
        <property type="gene ID" value="SDY_1357"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1357"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1608"/>
    <dbReference type="HOGENOM" id="CLU_067069_0_0_6"/>
    <dbReference type="OMA" id="NFKIFLD"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01200_B">
        <property type="entry name" value="OMPdecase_type1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000241906" description="Orotidine 5'-phosphate decarboxylase">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01200"/>
        </source>
    </evidence>
    <sequence length="245" mass="26326" checksum="3CF6E0E18BB934B9" modified="2005-12-06" version="1">MTLTASSSSRAVTNSPVVVALDYHNRDDALSFVDKIDPRDCRLKVGKEMFTLFGPQFVRELQQRGFDIFLDLKFHDIPNTAAHAVAAAADLGVWMVNVHASGGARMMTAAREALVPYGKDAPLLIAVTVLTSMEASDLADLGVTLSPADYAERLAALTQKCGFDGVVCSAQEAVRFKQVFGQEFKLVTPGIRPQGSDAGDQRRIMTPEQALAAGVDYMVIGRPVTQSVDPAQTLKAINASLQRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H07</accession>
    <name>Q32H07_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dihydroxyacetone kinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402889.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H07"/>
    <dbReference type="STRING" id="300267.SDY_1248"/>
    <dbReference type="EnsemblBacteria" id="ABB61398">
        <property type="protein sequence ID" value="ABB61398"/>
        <property type="gene ID" value="SDY_1248"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1248"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1482"/>
    <dbReference type="HOGENOM" id="CLU_171698_1_0_6"/>
    <dbReference type="OMA" id="FHRATSN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="111" mass="11887" checksum="0ED12469424D1234" modified="2005-12-06" version="1">MQRVIQLAQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPAALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H22</accession>
    <name>EMTA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo-type membrane-bound lytic murein transglycosylase A</fullName>
            <ecNumber evidence="1">4.2.2.n2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptidoglycan lytic endotransglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">emtA</name>
        <name type="synonym">mltE</name>
        <name type="ordered locus">SDY_1231</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endolytic cleavage of the (1-&gt;4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.</text>
            <dbReference type="EC" id="4.2.2.n2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB61382" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="4.2.2.n2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61382.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001310262.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402874.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H22"/>
    <dbReference type="SMR" id="Q32H22"/>
    <dbReference type="STRING" id="300267.SDY_1231"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61382">
        <property type="protein sequence ID" value="ABB61382"/>
        <property type="gene ID" value="SDY_1231"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1231"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1462"/>
    <dbReference type="HOGENOM" id="CLU_103257_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01381">
        <property type="entry name" value="EmtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023946">
        <property type="entry name" value="EmtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000312915" description="Endo-type membrane-bound lytic murein transglycosylase A">
        <location>
            <begin position="16"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="203" mass="22241" checksum="A510C14B103AC18C" modified="2008-01-15" version="2" precursor="true">MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGVLLRTFSSDRKKAISKINDLDADEFLDHVARNHPAPQAPRYIYKLEQALDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H82</accession>
    <name>Q32H82_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001204616.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402814.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H82"/>
    <dbReference type="EnsemblBacteria" id="ABB61323">
        <property type="protein sequence ID" value="ABB61323"/>
        <property type="gene ID" value="SDY_1166"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1166"/>
    <dbReference type="HOGENOM" id="CLU_1336761_0_0_6"/>
    <dbReference type="OMA" id="NWPNLAM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="205" mass="23925" checksum="764C37C3CFCBF19D" modified="2005-12-06" version="1">MRDGLLDSTKQAISERIKSPLWGFIILTWVWFNWPNLAMLFMSDAPVKFRIDYILLQEDFYLLFVVRPIAIGCLLAIASPYINLLLSKAHEWADDKHSKVVAKIKKRQLKDAIAFAKIQVEADRAKEIINHEIDIDKKIKEGKLKQEQLKQEQLNTESLKEEIEQMKRELETLAETKGNIRRARDKYVSDAKRYHFDVAVMPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HB4</accession>
    <name>Q32HB4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yebG</name>
        <name evidence="1" type="ordered locus">SDY_1134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000257738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402782.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HB4"/>
    <dbReference type="SMR" id="Q32HB4"/>
    <dbReference type="STRING" id="300267.SDY_1134"/>
    <dbReference type="EnsemblBacteria" id="ABB61291">
        <property type="protein sequence ID" value="ABB61291"/>
        <property type="gene ID" value="SDY_1134"/>
    </dbReference>
    <dbReference type="GeneID" id="66674262"/>
    <dbReference type="KEGG" id="sdy:SDY_1134"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1336"/>
    <dbReference type="HOGENOM" id="CLU_146554_1_0_6"/>
    <dbReference type="OMA" id="MAVITKF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009813">
        <property type="entry name" value="Uncharacterised_YebG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038627">
        <property type="entry name" value="YebG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07130">
        <property type="entry name" value="YebG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="96" mass="10717" checksum="006A837615BD49C7" modified="2005-12-06" version="1">MAVEVKYVVIREGEEKMSFTSKKEADAYDKMLDTADLLDTWLTNSPVQMEDEQREALSLWLAEQKDVLSTILKTGKLPSPQVVGAESEEEDASHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HF4</accession>
    <name>Q32HF4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytoplasmic alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">amyA</name>
        <name evidence="8" type="ordered locus">SDY_1088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001245709.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402742.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HF4"/>
    <dbReference type="STRING" id="300267.SDY_1088"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61251">
        <property type="protein sequence ID" value="ABB61251"/>
        <property type="gene ID" value="SDY_1088"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1088"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1278"/>
    <dbReference type="HOGENOM" id="CLU_024572_2_0_6"/>
    <dbReference type="OMA" id="FFHWYYP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="4"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001021-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001021-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="495" mass="56585" checksum="CCF97A023FEDCE96" modified="2005-12-06" version="1">MRNPTLLQCFHWYYPEGGKLWPELAERADGFNDIGINMVWLPPAYKGASGGYSVGYDSYDLFDLGEFDQKGSIPTKYGDKAQLLAAIDALKRNDIAVLLDVVVNHKMGADEKEAIRVQRVNADDRTQIDEEIIECEGWTRYTFPARAGQYSQFIWDFKCFSGIDHIENPDEDGIFKIVNDYTGEGWNDQVDDELGNFDYLMGENIDFRNHAVTEEIKYWARWVMEQTQCDGFRLDAVKHIPAWFYKEWIEHVQEVAPKPLFIVAEYWSHEVDKLQTYINQVEGKTMLFDAPLQMKFHEASRMGRDYDMTQIFTGTLVEADPFHAVTLVANHDTQPLQALEAPVEPWFKPLAYALILLRENGVPSVFYPDLYGAHYEDVGGDGQTYPIDMPIIEQLDELILARQRFAHGVQTLFFDHPNCIAFSRSGTDEYPGCVVVMSNGDDGEKTIHLGENYGNKTWRDFLGNRQESVVTDENGEATFFCNGGSVSVWVIEEVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HJ0</accession>
    <name>DGCQ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable diguanylate cyclase DgcQ</fullName>
            <shortName evidence="2">DGC</shortName>
            <ecNumber evidence="2">2.7.7.65</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Cellulose synthesis regulatory protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dgcQ</name>
        <name type="synonym">yedQ</name>
        <name type="ordered locus">SDY_1050</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24898"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="2.7.7.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; bacterial cellulose biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; 3',5'-cyclic di-GMP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB61215" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61215.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402706.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HJ0"/>
    <dbReference type="SMR" id="Q32HJ0"/>
    <dbReference type="STRING" id="300267.SDY_1050"/>
    <dbReference type="PRIDE" id="Q32HJ0"/>
    <dbReference type="EnsemblBacteria" id="ABB61215">
        <property type="protein sequence ID" value="ABB61215"/>
        <property type="gene ID" value="SDY_1050"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1050"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1227"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_23_6"/>
    <dbReference type="UniPathway" id="UPA00599"/>
    <dbReference type="UniPathway" id="UPA00694"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033416">
        <property type="entry name" value="CHASE7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17151">
        <property type="entry name" value="CHASE7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0135">Cellulose biosynthesis</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000248036" description="Probable diguanylate cyclase DgcQ">
        <location>
            <begin position="1"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="428"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P31129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P76330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="564" mass="64375" checksum="B549BD1E17168EB6" modified="2006-09-05" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HM2</accession>
    <name>Q32HM2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402674.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HM2"/>
    <dbReference type="STRING" id="300267.SDY_1018"/>
    <dbReference type="EnsemblBacteria" id="ABB61183">
        <property type="protein sequence ID" value="ABB61183"/>
        <property type="gene ID" value="SDY_1018"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1018"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="280" mass="32201" checksum="A8266C887AA89D3C" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNGFAPIFPDICYHLTHYKPAAADIPVASDNPAHYADAIRYNARTPLQGSLLPLTRLVWA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-12" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HQ6</accession>
    <name>NQOR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)H dehydrogenase (quinone)</fullName>
            <ecNumber evidence="1">1.6.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Flavoprotein WrbA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NAD(P)H:quinone oxidoreductase</fullName>
            <shortName evidence="1">NQO</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">SDY_0980</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + H(+) + NADH = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + H(+) + NADPH = a quinol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000170081.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402640.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HQ6"/>
    <dbReference type="SMR" id="Q32HQ6"/>
    <dbReference type="STRING" id="300267.SDY_0980"/>
    <dbReference type="EnsemblBacteria" id="ABB61149">
        <property type="protein sequence ID" value="ABB61149"/>
        <property type="gene ID" value="SDY_0980"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0980"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1139"/>
    <dbReference type="HOGENOM" id="CLU_051402_0_2_6"/>
    <dbReference type="OMA" id="KFADGNP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008753">
        <property type="term" value="F:NADPH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01017">
        <property type="entry name" value="NQOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037513">
        <property type="entry name" value="NQO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000291030" description="NAD(P)H dehydrogenase (quinone)">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="113"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01017"/>
        </source>
    </evidence>
    <sequence length="198" mass="20876" checksum="B74891D590DAC4EF" modified="2005-12-06" version="1">MTKVLVLYYSMYGHIETMARAVAEGASKVDGAEVVVKRVPETMPPQLFEKAGGKTQTAPVATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLASVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYAAQELFDVSQVRGGTPYGATTIAGGDGSRQPSQEELSIARYQGEYVAGLAVKLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HV0</accession>
    <name>Q32HV0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Outer membrane protein A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Outer membrane porin A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">ompA</name>
        <name evidence="16" type="ordered locus">SDY_0930</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells.</text>
    </comment>
    <comment type="function">
        <text evidence="13">With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell outer membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The extracellular loops are most variable in sequence, and in some bacteria confer sensitivity to phage and/or colicins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378625.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402596.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HV0"/>
    <dbReference type="STRING" id="300267.SDY_0930"/>
    <dbReference type="EnsemblBacteria" id="ABB61105">
        <property type="protein sequence ID" value="ABB61105"/>
        <property type="gene ID" value="SDY_0930"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0930"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1077"/>
    <dbReference type="HOGENOM" id="CLU_031536_0_0_6"/>
    <dbReference type="OMA" id="HDTGFYG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00842">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002368">
        <property type="entry name" value="OmpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000498">
        <property type="entry name" value="OmpA-like_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01389">
        <property type="entry name" value="OmpA_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01022">
        <property type="entry name" value="OUTRMMBRANEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="13" id="KW-0184">Conjugation</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0626">Porin</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026393123" description="Outer membrane protein A" evidence="13">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="15">
        <location>
            <begin position="214"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="site" description="Part of salt bridge gating mechanism" evidence="13">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="site" description="Part of salt bridge gating mechanism" evidence="13">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB61105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="350" mass="37495" checksum="E716D5301B4C5FD8" modified="2005-12-06" version="1" precursor="true">MKKTAIAITVALAGFATVAQAAPKDNTWYTGAKLGWSQYHDTGFIDNNGPTHENQLGAGAFGGYQVNPYVGFEMGYDWLGRMPYKGSVENGAYKAQGVQLTAKLGYPITDDLDIYTRLGGMVWRADTKANVPGGASFKDHDTGVSPVFAGGVEYAITPEIATRLEYQWTNNIGDAHTIGTRPDNGLLSLGVSYRFGQGEAAPVVAPAPAPAPEVQTKHFTLKSDVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVVDYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEVKGIKDVVTQPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I04</accession>
    <name>Q32I04_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferredoxin-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">napH</name>
        <name evidence="10" type="ordered locus">SDY_0874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000013518.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402542.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I04"/>
    <dbReference type="STRING" id="300267.SDY_0874"/>
    <dbReference type="EnsemblBacteria" id="ABB61051">
        <property type="protein sequence ID" value="ABB61051"/>
        <property type="gene ID" value="SDY_0874"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0874"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1009"/>
    <dbReference type="HOGENOM" id="CLU_066585_1_0_6"/>
    <dbReference type="OMA" id="CPVGAFY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011886">
        <property type="entry name" value="NapH_MauN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02163">
        <property type="entry name" value="napH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="287" mass="31918" checksum="E77DB94CDD3BD202" modified="2005-12-06" version="1">MANRKRDAGREALEKKGWWRSHRWLVLRRLCQFFVLGMFLSGPWFGVWILHGNYSSSLLFDTVPLTDPLMTLQSLASGHLPATVALTGAVIITVLYALEGKRLFCSWVCPLNPITDLANWLRRRFDLNQSATIPRHIRYVLLVVILVGSALTGTLIWEWINPVSLMGRSLVMGFGSGALLILALFLFDLLVVEHGWCGHICPVGALYGVLGSKGVITVAASDRQKCNRCMDCFHVCPEPHVLRAPVLDEQSPVQVTSRDCMTCGRCVDVCSEDVFTITTRWSSGAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I62</accession>
    <name>Q32I62_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybhP</name>
        <name evidence="2" type="ordered locus">SDY_0813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001113366.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402484.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I62"/>
    <dbReference type="STRING" id="300267.SDY_0813"/>
    <dbReference type="EnsemblBacteria" id="ABB60995">
        <property type="protein sequence ID" value="ABB60995"/>
        <property type="gene ID" value="SDY_0813"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0813"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.937"/>
    <dbReference type="HOGENOM" id="CLU_060500_3_2_6"/>
    <dbReference type="OMA" id="PHGDHGN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="253" mass="28819" checksum="464EDF450C6823DB" modified="2005-12-06" version="1">MPDQTQQFSFKVLTINIHKGFTAFNRRFILPELRDAVRTVSADIVCQQEVMGAHEVHPLHVENWPDTSHYEFLADTMWSDFAYGRNAVYPEGHHGNAVLSRYPIEHYENRDVSVDGAEKRGVLYCRIVPPMTGKAIHVMCVHLALREAHRQAQLAMLAEWVNELPDGEPVLVAGDFNDWRQKANHPLKVQAGLDEIFTRAHGRPARTFPVQFPLLRLDRIYVKNASASAPTALPLRTWRHLSDHAPLSAEIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I90</accession>
    <name>Q32I90_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_0784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402456.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I90"/>
    <dbReference type="STRING" id="300267.SDY_0784"/>
    <dbReference type="EnsemblBacteria" id="ABB60967">
        <property type="protein sequence ID" value="ABB60967"/>
        <property type="gene ID" value="SDY_0784"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0784"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.904"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="OMA" id="TWQLQFP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="9894" checksum="83E4E94966B91FD1" modified="2005-12-06" version="1">MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFPYTASQPGTHQKIIDMAMNGVGCRATARIMGVSLNTILRHLKNSGRSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IB7</accession>
    <name>GSIC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione transport system permease protein GsiC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gsiC</name>
        <name evidence="1" type="ordered locus">SDY_0756</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000936043.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402429.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IB7"/>
    <dbReference type="SMR" id="Q32IB7"/>
    <dbReference type="STRING" id="300267.SDY_0756"/>
    <dbReference type="EnsemblBacteria" id="ABB60940">
        <property type="protein sequence ID" value="ABB60940"/>
        <property type="gene ID" value="SDY_0756"/>
    </dbReference>
    <dbReference type="GeneID" id="66670895"/>
    <dbReference type="KEGG" id="sdy:SDY_0756"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.870"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_6"/>
    <dbReference type="OMA" id="MQEDYMR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000279998" description="Glutathione transport system permease protein GsiC">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="30"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="190"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="299"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="3">
        <location>
            <begin position="95"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P75798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="306" mass="34066" checksum="B74F4D9F2527AECE" modified="2005-12-06" version="1">MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPARLIAGPEADAQVIELVRQQLGLDQPLYHQFWHYISNAVQGDFGLSMVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELGWLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETWVVLKHGLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRYK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IG8</accession>
    <name>GAL1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Galactokinase</fullName>
            <ecNumber evidence="1">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">galK</name>
        <name type="ordered locus">SDY_0704</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000053411.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402378.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IG8"/>
    <dbReference type="SMR" id="Q32IG8"/>
    <dbReference type="STRING" id="300267.SDY_0704"/>
    <dbReference type="EnsemblBacteria" id="ABB60889">
        <property type="protein sequence ID" value="ABB60889"/>
        <property type="gene ID" value="SDY_0704"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0704"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.815"/>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_6"/>
    <dbReference type="OMA" id="PVCYNLR"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0299">Galactose metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000005762" description="Galactokinase">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <sequence length="382" mass="41423" checksum="77886CE6E648FB66" modified="2005-12-06" version="1">MSLKEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQLDEFSLDAPIVAHENYQWANYVRGVVKHLQLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQPALRDVTIEEFNAVAHELDPIVAKHVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKAVIGDKGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IJ0</accession>
    <name>Q32IJ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IJ0"/>
    <dbReference type="EnsemblBacteria" id="ABB60867">
        <property type="protein sequence ID" value="ABB60867"/>
        <property type="gene ID" value="SDY_0679"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0679"/>
    <dbReference type="HOGENOM" id="CLU_084718_0_0_6"/>
    <dbReference type="OMA" id="GWPSNDP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="229" mass="26311" checksum="FADBF20A4ADDD3D4" modified="2005-12-06" version="1">MSPDNIGSAVNRFSGWPSNDPLKTDEESMTSPVTVQVIKMIAAILAPHRIVVGIDTLYTTQRETFTSESQQLIESALQTLHVMNLNNLETNRDEEGHYLAFEYNVDISDRITVSAYNEKKPGCYGQCLVIQDDETNLFNLIKIKIFEAKHNYVAQLMSDPEFMFKFSYSAQQNRLEPHLLVPTYFPLKTNEPVTQEDILLLYRFFKMDGDFNILTSDEYMSIMTHSDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IL1</accession>
    <name>Q32IL1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltA</name>
        <name evidence="9" type="ordered locus">SDY_0658</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000132663.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402335.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IL1"/>
    <dbReference type="STRING" id="300267.SDY_0658"/>
    <dbReference type="EnsemblBacteria" id="ABB60846">
        <property type="protein sequence ID" value="ABB60846"/>
        <property type="gene ID" value="SDY_0658"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0658"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.769"/>
    <dbReference type="HOGENOM" id="CLU_025068_0_0_6"/>
    <dbReference type="OMA" id="TVGWCAQ"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="427" mass="47959" checksum="58595F3CC0649E77" modified="2005-12-06" version="1">MTDTKAKLTLNGDTAVELDVLKGTLGQDVIDIRTLGSKGVFTFDPGFTSTASCESKITFIDGDEGILLHRGFPIDQLATDSNYLEVCYILLNGEKPTQEQYDEFKTTVTRHTMIHEQITRLFHAFRRDSHPMAVMCGITGALAAFYHDSLDVNNPRHREIAAFRLLSKMPTMAAMCYKYSIGQPFVYPRNDLSYAGNFLNMMFSTPCEPYEVNPILECAMDRILILHADHEQNASTSTVRTAGSSGANPFACIAAGIASLWGPAHGGANEAALKMLEEISSVKHIPEFVRRAKDKNDSFRLMGFGHRVYKNYDPRATVMRETCHEVLKELGTKDDLLEVAMELENIALNDPYFIEKKLYPNVDFYSGIILKAMGIPSSMFTVIFAMARTVGWIAHWSEMHSDGMKIARPRQLYTGYEKRDFKSDVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IP4</accession>
    <name>Q32IP4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IP4"/>
    <dbReference type="STRING" id="300267.SDY_0620"/>
    <dbReference type="EnsemblBacteria" id="ABB60813">
        <property type="protein sequence ID" value="ABB60813"/>
        <property type="gene ID" value="SDY_0620"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0620"/>
    <dbReference type="HOGENOM" id="CLU_079781_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005318">
        <property type="entry name" value="OM_porin_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34596">
        <property type="entry name" value="PTHR34596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03573">
        <property type="entry name" value="OprD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="223" mass="25254" checksum="A8148B341103C96A" modified="2005-12-06" version="1">MPGTYQGAEAGANFDYGDAGALSFSYMWTNEYKAPWHLEMDEFYQNDKTTKVDYLHSIGAKYDFKNNFVLEAAFGQAEGYIDQYFAKASYKFDIAGSPLTTSYQFYGTCDKVDDRSVNDLYDGTAWLQALTFGYRAADVVDLRLEGTWVKADGQQGYFLQRMTPTYASSNGRLDIWWDNRSDFNANGEKAVFFGAMYDLKNWNLPGFAIGASYVYAWDAKPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IU6</accession>
    <name>Q32IU6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidoglycan glycosyltransferase MrdB</fullName>
            <shortName evidence="9">PGT</shortName>
            <ecNumber evidence="9">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cell elongation protein RodA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cell wall polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Peptidoglycan polymerase</fullName>
            <shortName evidence="9">PG polymerase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">mrdB</name>
        <name evidence="9" type="synonym">rodA</name>
        <name evidence="10" type="ordered locus">SDY_0556</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Peptidoglycan polymerase that is essential for cell wall elongation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEDS family. MrdB/RodA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000131722.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402250.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IU6"/>
    <dbReference type="STRING" id="300267.SDY_0556"/>
    <dbReference type="EnsemblBacteria" id="ABB60761">
        <property type="protein sequence ID" value="ABB60761"/>
        <property type="gene ID" value="SDY_0556"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0556"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.658"/>
    <dbReference type="HOGENOM" id="CLU_029243_2_2_6"/>
    <dbReference type="OMA" id="IFCTVGE"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02079">
        <property type="entry name" value="PGT_RodA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="370" mass="40404" checksum="CD023EB061C4DDBE" modified="2005-12-06" version="1">MTDNPNKKTFWDKVHLDPTMLLILLALLVYSALVIWSASGQDIGMMGRKIGQIAMGLVIMVVMAQIPPRVYEGWAPYLYIICIILLVAVDAFGAISKGAQRWLDLGIVRFQPSEIAKIAVPLMVARFINRDVCPPSLKNTGIALVLIFMPTLLVAAQPDLGTSILVALSGLFVLFLSGLSWRLIGVAVVLVAAFIPILWFFLMHDYQRQRVMMLLDPESDPLGAGYHIIQSKIAIGSGGLRGKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLVGILILLALYILLIMRGLWIAARAQTTFGRVMAGGLMLILFVYVFVNIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIHTHRKMLSKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IV3</accession>
    <name>Q32IV3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable Sec-independent protein translocase protein TatE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ybeC</name>
        <name evidence="7" type="synonym">tatE</name>
        <name evidence="8" type="ordered locus">SDY_0549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family. TatE subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000503931.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402243.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IV3"/>
    <dbReference type="SMR" id="Q32IV3"/>
    <dbReference type="STRING" id="300267.SDY_0549"/>
    <dbReference type="EnsemblBacteria" id="ABB60754">
        <property type="protein sequence ID" value="ABB60754"/>
        <property type="gene ID" value="SDY_0549"/>
    </dbReference>
    <dbReference type="GeneID" id="67416330"/>
    <dbReference type="KEGG" id="sdy:SDY_0549"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.650"/>
    <dbReference type="HOGENOM" id="CLU_086034_5_3_6"/>
    <dbReference type="OMA" id="KDGMREG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00903">
        <property type="entry name" value="TatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024905">
        <property type="entry name" value="TatE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7024" checksum="FA880C6DECE248A3" modified="2005-12-06" version="1">MGEISITKLLVVAALVVLLFGTKKLRTLGGDLGAAIKGFKKAMNDDDAAAKKGADVDLQAEKLSHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IZ2</accession>
    <name>Q32IZ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IZ2"/>
    <dbReference type="EnsemblBacteria" id="ABB60715">
        <property type="protein sequence ID" value="ABB60715"/>
        <property type="gene ID" value="SDY_0508"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0508"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="RSNWRVE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="206" mass="23426" checksum="4A51301AF90C110A" modified="2005-12-06" version="1">MPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGGRNWRSNWRVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IZ8</accession>
    <name>Q32IZ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tauD</name>
        <name evidence="3" type="ordered locus">SDY_0502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000004058.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402198.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IZ8"/>
    <dbReference type="STRING" id="300267.SDY_0502"/>
    <dbReference type="EnsemblBacteria" id="ABB60709">
        <property type="protein sequence ID" value="ABB60709"/>
        <property type="gene ID" value="SDY_0502"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0502"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.593"/>
    <dbReference type="HOGENOM" id="CLU_036005_2_1_6"/>
    <dbReference type="OMA" id="FVDAYPK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="2">
        <location>
            <begin position="7"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="283" mass="32371" checksum="7ADE0D5DC9CC3B57" modified="2005-12-06" version="1">MSERLSITPLGPYIGAQISGADLTRSLSDNQFEQLYHAVLRHQVVFLRDQAITPQQQRALAQRFGELHIHPVYPHAEGVDEIIVLDTHNDNPPDNDNWHTDVTFIETPPAGAILAAKELPSTGGDTLWTSGIAAYEALSVPFRQLLSGLRAEHDFRKSFPEYKYRKTEEEHQRWREAVAKNPPLLHPVVRTHPVSGKQALFVNEGFTTRIVDVSEKESEALLSFLFAHITKPEFQVRWRWQPNDIAIWDNRVTQHYANADYLPQRRIMHQATILGDKPFYRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J50</accession>
    <name>Q32J50_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">dnaX</name>
        <name evidence="8" type="ordered locus">SDY_0449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000122004.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402146.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J50"/>
    <dbReference type="STRING" id="300267.SDY_0449"/>
    <dbReference type="EnsemblBacteria" id="ABB60657">
        <property type="protein sequence ID" value="ABB60657"/>
        <property type="gene ID" value="SDY_0449"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0449"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.532"/>
    <dbReference type="HOGENOM" id="CLU_006229_6_0_6"/>
    <dbReference type="OMA" id="YALHQGN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022001">
        <property type="entry name" value="DNA_pol3_tau_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021029">
        <property type="entry name" value="DNA_pol_III_tau_dom-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038249">
        <property type="entry name" value="PolIII_tau_V_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12168">
        <property type="entry name" value="DNA_pol3_tau_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12170">
        <property type="entry name" value="DNA_pol3_tau_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="37"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="643" mass="71189" checksum="451F5B7FF9E35EDA" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J70</accession>
    <name>Q32J70_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J70"/>
    <dbReference type="EnsemblBacteria" id="ABB60637">
        <property type="protein sequence ID" value="ABB60637"/>
        <property type="gene ID" value="SDY_0426"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0426"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7318" checksum="CA49B3CB16D05300" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITEIILPLLIVGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J87</accession>
    <name>Q32J87_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybbL</name>
        <name evidence="5" type="ordered locus">SDY_0409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001157535.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402109.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J87"/>
    <dbReference type="STRING" id="300267.SDY_0409"/>
    <dbReference type="EnsemblBacteria" id="ABB60620">
        <property type="protein sequence ID" value="ABB60620"/>
        <property type="gene ID" value="SDY_0409"/>
    </dbReference>
    <dbReference type="GeneID" id="66671208"/>
    <dbReference type="KEGG" id="sdy:SDY_0409"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.486"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="SSKIEHM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="225" mass="25354" checksum="FE2D07A4A991A250" modified="2005-12-06" version="1">MQENSPLLQLQNVGYLAGDAKILNNINFSLRAGEFKLITGPSGCGKSTLLKIVASLISPTSGTLLFEGEDVSTLKPEIYRQQVSYCAQTPTLFGDTVYDNLIFPWQIRNQQPDPAIFLDFLERFALPDSILTKNIAELSGGEKQRISLIRNLQFMPKVLLLDEITSALDESNKHNVNEMIHRYVREQNIAVLWVTHDKDEINHADKVITLQPHAGEMQEARYELA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J96</accession>
    <name>SELU_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA 2-selenouridine synthase</fullName>
            <ecNumber evidence="1">2.9.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">selU</name>
        <name type="ordered locus">SDY_0399</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42716"/>
            <dbReference type="Rhea" id="RHEA-COMP:10195"/>
            <dbReference type="Rhea" id="RHEA-COMP:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:74455"/>
            <dbReference type="ChEBI" id="CHEBI:82743"/>
            <dbReference type="ChEBI" id="CHEBI:143703"/>
            <dbReference type="EC" id="2.9.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:42717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA = 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10195"/>
            <dbReference type="Rhea" id="RHEA-COMP:14654"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:74455"/>
            <dbReference type="ChEBI" id="CHEBI:140632"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:14086"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:60172"/>
            <dbReference type="Rhea" id="RHEA-COMP:14654"/>
            <dbReference type="Rhea" id="RHEA-COMP:15523"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:140632"/>
            <dbReference type="ChEBI" id="CHEBI:143702"/>
            <dbReference type="ChEBI" id="CHEBI:143703"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:60173"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O = 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate</text>
            <dbReference type="Rhea" id="RHEA:60176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10196"/>
            <dbReference type="Rhea" id="RHEA-COMP:15523"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82743"/>
            <dbReference type="ChEBI" id="CHEBI:143702"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:60177"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SelU family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001157988.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402100.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J96"/>
    <dbReference type="SMR" id="Q32J96"/>
    <dbReference type="STRING" id="300267.SDY_0399"/>
    <dbReference type="EnsemblBacteria" id="ABB60611">
        <property type="protein sequence ID" value="ABB60611"/>
        <property type="gene ID" value="SDY_0399"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0399"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.473"/>
    <dbReference type="HOGENOM" id="CLU_043456_1_0_6"/>
    <dbReference type="OMA" id="RPLVYCW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043828">
        <property type="term" value="F:tRNA 2-selenouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01622">
        <property type="entry name" value="tRNA_sel_U_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017582">
        <property type="entry name" value="SelU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03167">
        <property type="entry name" value="tRNA_sel_U_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0711">Selenium</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000292717" description="tRNA 2-selenouridine synthase">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="S-selanylcysteine intermediate" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01622"/>
        </source>
    </evidence>
    <sequence length="364" mass="41102" checksum="5CC469B0EB409816" modified="2005-12-06" version="1">MQERHTEQDYRALLIADTPIIDVRAPIEFEQGAMPAAINLPLMNNDERAAVGTCYKQQGSDAALALGHKLVAGEIRQQRMDAWRAACLQNPQGILCCARGGQRSHIVQSWLHAAGIDYPLVEGGYKALRQTAIQATIELAQKPIVLIGGCTGSGKTLLVQQQPNGVDLEGLARHRGSAFGRTLQPQLSQASFENLLAAEMLKTDARQNLRLWVLEDESRMIGSNHLPECLRERMTQAAIAVVEDPFEIRLERLNEEYFLRMHHDFTHAYGDEQGWQEYCEYLHHGLSAIKRRLGLQRYNELAARLDAALTTQLTTGSTDGHLAWLVPLLEEYYDPMYRYQLEKKAEKVVFRGEWAEVAEWVKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JC2</accession>
    <name>Q32JC2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_46 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402074.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JC2"/>
    <dbReference type="STRING" id="300267.SDY_0371"/>
    <dbReference type="EnsemblBacteria" id="ABB60585">
        <property type="protein sequence ID" value="ABB60585"/>
        <property type="gene ID" value="SDY_0371"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0371"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.439"/>
    <dbReference type="HOGENOM" id="CLU_198193_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041687">
        <property type="entry name" value="HTH_46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15977">
        <property type="entry name" value="HTH_46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_46" evidence="1">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="77" mass="8903" checksum="41B4AE59FE7A4475" modified="2005-12-06" version="1">MQLIGHNSYEQIRATLLSMIDWNEELRSRIGVMNYIHQRTRISRSVVAEVLAALRKGGYIEMNKGKLVAINRLPSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JE8</accession>
    <name>Q32JE8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible NAGC-like transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yajF</name>
        <name evidence="1" type="ordered locus">SDY_0345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JE8"/>
    <dbReference type="STRING" id="300267.SDY_0345"/>
    <dbReference type="EnsemblBacteria" id="ABB60560">
        <property type="protein sequence ID" value="ABB60560"/>
        <property type="gene ID" value="SDY_0345"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0345"/>
    <dbReference type="HOGENOM" id="CLU_036604_0_3_6"/>
    <dbReference type="OMA" id="DHLVMIT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="348" mass="37545" checksum="12DEA7FDEF5697DE" modified="2005-12-06" version="1">MNHSMIISTALSLNLAGMITNCRRPCIANPVVHLYAIDIEKNKESTVRIGIDLGGTKTEVIALGDAGEQLYRHRLPTPRDDYRQTIETIATLVDMAEQATGQRGTVGMGIPGSISPYTGVVKNANSTWLNGQPFDKDLSARLQREVRLANDANCLAVSEAVDGAAAGAQTVFAVIIGTGCGAGVAFNGRAHIGGNGTAGEWGHNPLPWMDEDELRYREEVPCYCGKQGCIETFISGTGFATDYRRLSGHALKGSEIIRLVEESDPVAELALRRYELRLAKSLAHVVNILDPDVIVLGGGMSNVDRLYQTVPQLIKQFVFGGECETPVRKAKHGDSSGVRGAAWLWPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JF7</accession>
    <name>Q32JF7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JF7"/>
    <dbReference type="EnsemblBacteria" id="ABB60550">
        <property type="protein sequence ID" value="ABB60550"/>
        <property type="gene ID" value="SDY_0331"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0331"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="9043" checksum="CDB2B4DF496BEEE3" modified="2005-12-06" version="1">MAVTAAKSVMAFRVMTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITVCSMLLVSVCIMLLVMAVHGMQVYYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JG8</accession>
    <name>Q32JG8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">ribD</name>
        <name evidence="15" type="ordered locus">SDY_0320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001150433.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402028.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JG8"/>
    <dbReference type="STRING" id="300267.SDY_0320"/>
    <dbReference type="EnsemblBacteria" id="ABB60539">
        <property type="protein sequence ID" value="ABB60539"/>
        <property type="gene ID" value="SDY_0320"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0320"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.369"/>
    <dbReference type="HOGENOM" id="CLU_036590_1_2_6"/>
    <dbReference type="OMA" id="DEMYMAR"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="301"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB60539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="367" mass="40343" checksum="FC8D1A74B2BC02B5" modified="2005-12-06" version="1">MQDEYYMARALKLAQRGRFTTHPNPNVGCVIVKDGEIVGEGYHQRAGEPHAEVHALRMAGEKAKGATAYVTLEPCSHHGRTPPCCDALIAAGVARVVAAMQDPNPQVAGRGLYRLQQAGIDVSHGLMMSEAEQLNKGFLKRMRTGFPYIQLKLGASLDGRTAMASGESQWITSPQARRDVQRLRAQSHAILTSSATVLADDPALTVRWSELDEQTQALYPQQNLHQPVRIVIDSQNRVTPEHHIVQQPGETWFARTQEDSREWPETVRTLLIPEHKGHLDLVVLMMQLGKQQINSIWVEAGPTLAGALLQAGLVDELIVYIAPKLLGSDARGLCTLPGLEKLADAPQFKFKEIRHVGPDVCLHLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JL9</accession>
    <name>Q32JL9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multicopy suppressor of dominant negative ftsH mutants</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdrA</name>
        <name evidence="3" type="ordered locus">SDY_0268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000580892.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401977.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JL9"/>
    <dbReference type="STRING" id="300267.SDY_0268"/>
    <dbReference type="EnsemblBacteria" id="ABB60488">
        <property type="protein sequence ID" value="ABB60488"/>
        <property type="gene ID" value="SDY_0268"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0268"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.307"/>
    <dbReference type="HOGENOM" id="CLU_026233_1_0_6"/>
    <dbReference type="OMA" id="KARRWES"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="2">
        <location>
            <begin position="200"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Ligase_CoA" evidence="1">
        <location>
            <begin position="337"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="556" mass="58534" checksum="DCF2678B3A23F32F" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JN5</accession>
    <name>Q32JN5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yafJ</name>
        <name evidence="2" type="ordered locus">SDY_0249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000333379.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401961.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JN5"/>
    <dbReference type="SMR" id="Q32JN5"/>
    <dbReference type="STRING" id="300267.SDY_0249"/>
    <dbReference type="EnsemblBacteria" id="ABB60472">
        <property type="protein sequence ID" value="ABB60472"/>
        <property type="gene ID" value="SDY_0249"/>
    </dbReference>
    <dbReference type="GeneID" id="58390879"/>
    <dbReference type="KEGG" id="sdy:SDY_0249"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.280"/>
    <dbReference type="HOGENOM" id="CLU_059273_0_0_6"/>
    <dbReference type="OMA" id="YWVFAHN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="255" mass="28579" checksum="0ED054C4A923A0BC" modified="2005-12-06" version="1">MCELLGMSANVPTDICFSFTGLVQRGGGTGPHKDGWGITFYEGKGCRTFKDPQPSFNSPIAKLVQDYPIKSCSVVAHIRQANRGEVALENTHPFTRELWGRNWTYAHNGQLTGYKSLETGNFRPVGETDSEKAFCWLLHKLTQRYPRTPGNMAAVFKYIASLADELRAKGVFNMLLSDGRYVMAYCSTNLHWITRRAPFGVATLLDQDVEIDFSSQTTPNDVVTVIATQPLTGNETWQKIMPGEWRLFCLGERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JY4</accession>
    <name>Q32JY4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadC</name>
        <name evidence="13" type="ordered locus">SDY_0139</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001135150.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401862.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JY4"/>
    <dbReference type="STRING" id="300267.SDY_0139"/>
    <dbReference type="EnsemblBacteria" id="ABB60373">
        <property type="protein sequence ID" value="ABB60373"/>
        <property type="gene ID" value="SDY_0139"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0139"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.157"/>
    <dbReference type="HOGENOM" id="CLU_039622_0_3_6"/>
    <dbReference type="OMA" id="DMIMLKD"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="12">
        <location>
            <begin position="43"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="131"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="280"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB60373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="297" mass="32786" checksum="00982802425BA740" modified="2005-12-06" version="1">MPPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATVITRENGLFCGKRWVEEVFIQLAGDDVTIIWHVDDGDVINANQPLFELEGPSRVLLTGERTALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLRSALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFETEQMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q326T5</accession>
    <name>Q326T5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IpaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ipaJ</name>
        <name evidence="1" type="ordered locus">SDY_P160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406161.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326T5"/>
    <dbReference type="EnsemblBacteria" id="ABB64673">
        <property type="protein sequence ID" value="ABB64673"/>
        <property type="gene ID" value="SDY_P160"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P160"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5718"/>
    <dbReference type="HOGENOM" id="CLU_1146568_0_0_6"/>
    <dbReference type="OMA" id="NPRTHKD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="227" mass="25178" checksum="46C7ABB1F9EF054C" modified="2005-12-06" version="1">MISHQTDVRVNENRVNEQGCFLARKQMYDNSCGAASLLCAAKELGVDKIPQYKGSMSEMTRKSSLDLDNRCERDLYLITSGNYNPRTHKDNIADAGYSMPDKIVMATRLLGLNAYVVEESNIFSQVISFIYPDARDLLIGMGCNIVHQRDVLSSNQRVLEAVAVSFIGVPVGLHWVLCRPDGSYMDPAVGENYSCFSTMELGARRSNSNFIGYTKIGISIVITNEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q327F1</accession>
    <name>Q327F1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406045.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327F1"/>
    <dbReference type="EnsemblBacteria" id="ABB64557">
        <property type="protein sequence ID" value="ABB64557"/>
        <property type="gene ID" value="SDY_P044"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P044"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5589"/>
    <dbReference type="HOGENOM" id="CLU_036805_12_7_6"/>
    <dbReference type="OMA" id="CFAVMAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="55" mass="6229" checksum="66FBB53A30AF7D76" modified="2005-12-06" version="1">MDEKKLKALAAELAKGLKTEADLNQFSRMQTKLTVETVLNAELTDHLGHEKSYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q327F4</accession>
    <name>Q327F4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_P041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406042.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327F4"/>
    <dbReference type="EnsemblBacteria" id="ABB64554">
        <property type="protein sequence ID" value="ABB64554"/>
        <property type="gene ID" value="SDY_P041"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P041"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5585"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14940" checksum="19F8827D74CEE84E" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLLPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKALSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q327L3</accession>
    <name>DEOB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphopentomutase</fullName>
            <ecNumber evidence="1">5.4.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphodeoxyribomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">deoB</name>
        <name type="ordered locus">SDY_4643</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphotransfer between the C1 and C5 carbon atoms of pentose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-ribose 1-phosphate = D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:18793"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="5.4.2.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27658"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="5.4.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 or 2 manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphopentomutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000816482.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405983.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327L3"/>
    <dbReference type="SMR" id="Q327L3"/>
    <dbReference type="STRING" id="300267.SDY_4643"/>
    <dbReference type="EnsemblBacteria" id="ABB64492">
        <property type="protein sequence ID" value="ABB64492"/>
        <property type="gene ID" value="SDY_4643"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4643"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5504"/>
    <dbReference type="HOGENOM" id="CLU_053861_0_0_6"/>
    <dbReference type="OMA" id="YLGNCHA"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043094">
        <property type="term" value="P:cellular metabolic compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16009">
        <property type="entry name" value="PPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00740">
        <property type="entry name" value="Phosphopentomut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010045">
        <property type="entry name" value="DeoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024052">
        <property type="entry name" value="Phosphopentomutase_DeoB_cap_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21110">
        <property type="entry name" value="PTHR21110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001491">
        <property type="entry name" value="Ppentomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143856">
        <property type="entry name" value="SSF143856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01696">
        <property type="entry name" value="deoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000258304" description="Phosphopentomutase">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00740"/>
        </source>
    </evidence>
    <sequence length="407" mass="44381" checksum="66486993730939B0" modified="2005-12-06" version="1">MKRAFIMVLDSFGIGATEDAERFGDVGADTLGHIAEACAKGKADNGRKGPLNLPNLTRLGLAKAHEGSTGFIPAGMDGNAEVIGAYAWAHEMSSGKDTPSGHWEIAGVPVLFEWGYFSDHENSFPQELLDKLVERANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELINGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAPTVLQKLVDEKHGQVVSVGKIADIYANCGITKKVKATGLDALFDATIKEMKEAGDNTIVFTNFVDFDSSWGHRRDVAGYAAGLELFDRRLPELMSLLRDDDILILTADHGCDPTWTGTDHTREHIPVLVYGPKVKPGSLGHRETFADIGQTLAKYFGTSDMEYGKAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q327U1</accession>
    <name>Q327U1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yhjD</name>
        <name evidence="5" type="ordered locus">SDY_4542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000191252.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405905.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327U1"/>
    <dbReference type="STRING" id="300267.SDY_4542"/>
    <dbReference type="EnsemblBacteria" id="ABB64414">
        <property type="protein sequence ID" value="ABB64414"/>
        <property type="gene ID" value="SDY_4542"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4542"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5370"/>
    <dbReference type="HOGENOM" id="CLU_050028_0_2_6"/>
    <dbReference type="OMA" id="MGNQFGA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005274">
        <property type="entry name" value="IM_pro_YhjD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00766">
        <property type="entry name" value="TIGR00766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="337" mass="37896" checksum="2CE5AF3E2D7D8694" modified="2005-12-06" version="1">MTQENEIKRPTQDLEHEPIKQLDNSEKGGKVSQALETVTTTAEKVQRQPIIAHLIRATERFNDRLGNQFGAAITYFSFLSMIPILMVSFAAGGFVLASHPMLLQDIFDKILQNISDPTLAATLKNTINTAVQQRTTVGLVGLAVALYSGINWMGNLREAIRAQSRDVWERSPQDQEKFWVKYLRDFISLIGLLIALIVTLSITSVAGSAQQIIISALHLNSIEWLKPTWRLIGLAISIFANYLLFFWIFWRLPRHRPRKKALIRGTFLAAIGFEVIKIVMTYTLPSLMKSPSGAAFGSVLGLMAFFYFFARLTLFCAAWIATAEYKDDPRMPGKTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Y6</accession>
    <name>Q327Y6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Y6"/>
    <dbReference type="STRING" id="300267.SDY_4493"/>
    <dbReference type="EnsemblBacteria" id="ABB64369">
        <property type="protein sequence ID" value="ABB64369"/>
        <property type="gene ID" value="SDY_4493"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4493"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_1_6"/>
    <dbReference type="OMA" id="METTFML"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038965">
        <property type="entry name" value="InsF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46889:SF1">
        <property type="entry name" value="PTHR46889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="173" mass="20317" checksum="821FB68770503352" modified="2005-12-06" version="1">MTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKPGGVMFHSDQGSHYTSRQFRQLLWRYQIRQSMSRRGNCWDNSPMERFFRSLKNEWMPVVGYVSFSEAAHAITDYIVRYYSALRPHEYNGGLPPNESENRYWKNSNSVASFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q328B3</accession>
    <name>Q328B3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable growth inhibitor, PemK-like, autoregulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">chpB</name>
        <name evidence="1" type="ordered locus">SDY_4461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000239577.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405833.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328B3"/>
    <dbReference type="SMR" id="Q328B3"/>
    <dbReference type="STRING" id="300267.SDY_4461"/>
    <dbReference type="EnsemblBacteria" id="ABB64342">
        <property type="protein sequence ID" value="ABB64342"/>
        <property type="gene ID" value="SDY_4461"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4461"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5262"/>
    <dbReference type="HOGENOM" id="CLU_121823_2_1_6"/>
    <dbReference type="OMA" id="RVISMID"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="116" mass="12492" checksum="4D641F3E302FCF58" modified="2005-12-06" version="1">MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLVNQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q328R3</accession>
    <name>Q328R3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Citrate-dependent iron transporter membrane-bound protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fecD</name>
        <name evidence="8" type="ordered locus">SDY_4294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000684858.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405683.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328R3"/>
    <dbReference type="STRING" id="300267.SDY_4294"/>
    <dbReference type="EnsemblBacteria" id="ABB64192">
        <property type="protein sequence ID" value="ABB64192"/>
        <property type="gene ID" value="SDY_4294"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4294"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5062"/>
    <dbReference type="HOGENOM" id="CLU_013016_1_1_6"/>
    <dbReference type="OMA" id="SFRMPRI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="318" mass="34150" checksum="0FDDE424A79423A2" modified="2005-12-06" version="1">MKIALVIFITLALAGCALLSLHMGVIPVPWRALLTDWQAGREHYYVLMEYRLPRLLLALFVGAALAVAGVLIQGIVRNPLASPDILGVNHAASLASVGALLLMPSLPVMVLPLLAFAGGMAGLILLKMLAKTHQPMKLALTGVALSACWASLTDYLMLSRPQDVNNALLWLTGSLWGRDWSFVKIAIPLMILFLPLSLSFCRDLDLLALGDARATTLGVSVPHTRFWALLLAVAMTSTGVAACGPISFIGLVVPHMMRSITGGRHRRLLPVSALTGALLLVVADLLARIIHPPLQLPVGVLTAIIGAPWFVWLLVRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q328R8</accession>
    <name>Q328R8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF853 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjgR</name>
        <name evidence="2" type="ordered locus">SDY_4287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378959.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405678.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328R8"/>
    <dbReference type="STRING" id="300267.SDY_4287"/>
    <dbReference type="EnsemblBacteria" id="ABB64187">
        <property type="protein sequence ID" value="ABB64187"/>
        <property type="gene ID" value="SDY_4287"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4287"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5054"/>
    <dbReference type="HOGENOM" id="CLU_028164_1_1_6"/>
    <dbReference type="OMA" id="TTEYGNI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF853" evidence="1">
        <location>
            <begin position="4"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="500" mass="54534" checksum="AB9C241E38611456" modified="2005-12-06" version="1">MSEPLLIARTPDTELFLLPGMANRHGLITGATGTGKTVTLQKLAESLSEIGVPVFMADVKGDLTGIAQTGTTSEKLLARLKNIGVNDWQAHANPVVVWDIFGEKGHLVRATVSDLGPLLLARLLNLNDVQSGVLNIIFRIADDQGLLLLDFKDLQAITQYIGDNAKSFQNQYGNISSASVGAIQRGLLSLEQQGAAHFFGEPMLDIKDWMRTDANGKGVINILSAEKLYQMPKLYAASLLWMLSELYEQLLEAGDLEKPKLVFFFDEAHLLFNDAPQVLLDKIEQVIRLIRSKGVGVWFVSQNPSDIPDNVLGQLGNRVQHALRAFTPKDQKAVKAAAQTMRANPAFYTEKAIQELGTGEALISFLDAKGSPSVVERAMVIAPCSRMGPVTEDERNGLINHSPMYGKYEDDVDRESAYEMLQKGFQASIEQQNNPPAKGKEVAVDDGILGGLKDILFGTTGPRGGKKDGVVQTMAKSAARQVTNQIVRGMLGSLLGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q328U6</accession>
    <name>Q328U6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trehalase 6-P hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">treC</name>
        <name evidence="4" type="ordered locus">SDY_4258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016308.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405650.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328U6"/>
    <dbReference type="STRING" id="300267.SDY_4258"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64159">
        <property type="protein sequence ID" value="ABB64159"/>
        <property type="gene ID" value="SDY_4258"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4258"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5020"/>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_6"/>
    <dbReference type="OMA" id="PNGEKWA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008788">
        <property type="term" value="F:alpha,alpha-phosphotrehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012769">
        <property type="entry name" value="Trehalose_TreC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02403">
        <property type="entry name" value="trehalose_treC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="15"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="551" mass="63908" checksum="07E983810EE0AFAD" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q329B1</accession>
    <name>MNME_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="1">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmE</name>
        <name evidence="1" type="synonym">trmE</name>
        <name type="ordered locus">SDY_4189</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001282344.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405585.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329B1"/>
    <dbReference type="SMR" id="Q329B1"/>
    <dbReference type="STRING" id="300267.SDY_4189"/>
    <dbReference type="EnsemblBacteria" id="ABB64094">
        <property type="protein sequence ID" value="ABB64094"/>
        <property type="gene ID" value="SDY_4189"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4189"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4926"/>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_6"/>
    <dbReference type="OMA" id="CEIQCHG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000048877" description="tRNA modification GTPase MnmE">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="TrmE-type G">
        <location>
            <begin position="216"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="226"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="245"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="335"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="358"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <sequence length="454" mass="49213" checksum="1E94CD08BD4583BB" modified="2005-12-06" version="1">MSDNDTIVAQATPPGRGGVGILRISGFKAREVAETVLGKLPKPRYADYLPFKDADGSVLDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTIPGLRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNDVIADLDAVRAEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREASDEVERIGIERAWQEIEQADRVLFMVDGTTTDAVDPAEIWPEFIARLPAKLPITVVRNKADITGETLGISEVNGHALIRLSARTGEGVDVLRNHLKQSMGFDTNMEGGFLARRRHLQALEQAAEHLQQGKAQLLGAWAGELLAEELRLAQQNLSEITGEFTSDDLLGRIFSSFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q329F2</accession>
    <name>Q329F2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000125645.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405544.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329F2"/>
    <dbReference type="STRING" id="300267.SDY_4143"/>
    <dbReference type="EnsemblBacteria" id="ABB64053">
        <property type="protein sequence ID" value="ABB64053"/>
        <property type="gene ID" value="SDY_4143"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4143"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4870"/>
    <dbReference type="HOGENOM" id="CLU_144725_0_0_6"/>
    <dbReference type="OMA" id="VQKWEIG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="107" mass="11701" checksum="4B5485C2E64DA2BB" modified="2005-12-06" version="1">MTAKTKFKSPAFEAIHSAAAGLSSVDAIYAETMRTFDKACLTSVQDLQPVEIKALREKLKVSQPVFAHYLNTSVSTVQKWESGAKRPNGISLKLLSIVQKHGLDVLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A72</accession>
    <name>RHAT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-rhamnose-proton symporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-rhamnose-H(+) transport protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhaT</name>
        <name type="ordered locus">SDY_3839</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-rhamnopyranose(out)</text>
            <dbReference type="Rhea" id="RHEA:29947"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62346"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:29949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000063521.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405274.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A72"/>
    <dbReference type="STRING" id="300267.SDY_3839"/>
    <dbReference type="EnsemblBacteria" id="ABB63783">
        <property type="protein sequence ID" value="ABB63783"/>
        <property type="gene ID" value="SDY_3839"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3839"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4534"/>
    <dbReference type="HOGENOM" id="CLU_066437_0_0_6"/>
    <dbReference type="OMA" id="QFFFYGM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015153">
        <property type="term" value="F:rhamnose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01532">
        <property type="entry name" value="RhaT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004673">
        <property type="entry name" value="L-rhamnose-proton_sym_RhaT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06379">
        <property type="entry name" value="RhaT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0769">Symport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000292767" description="L-rhamnose-proton symporter">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01532"/>
        </source>
    </evidence>
    <sequence length="344" mass="37369" checksum="5D05734AA73917BB" modified="2005-12-06" version="1">MSNAITMGIFWHLIGAASAACFYAPFKKVKKWSWETMWSVGGIVSWIILPWAISALLLPNFWAYYSSFSLSTLLPVFLFGAMWGIGNINYGLTMRYLGMSMGIGIAIGITLIVGTLMTPIINGNFDVLISTEGGRMTLLGVLVALIGVGIVTRAGQLKERKMGIKAEEFNLKKGLVLAVMCGIFSAGMSFAMNAAKPMYEAAAALGVDPLYVALPSYVVIMGGGAIINLGFCFIRLAKVKDLSLKVDFSLEKPLIIHNVLLSALGGLMWYLQFFFYAWGHARIPAQYDYISWMLHMSFYVLCGGIVGLVLKEWNNAGRRPVTVLSLGCVVIIVAANIVGIGMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AI1</accession>
    <name>Q32AI1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS4 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AI1"/>
    <dbReference type="STRING" id="300267.SDY_3714"/>
    <dbReference type="EnsemblBacteria" id="ABB63674">
        <property type="protein sequence ID" value="ABB63674"/>
        <property type="gene ID" value="SDY_3714"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3714"/>
    <dbReference type="HOGENOM" id="CLU_028400_3_0_6"/>
    <dbReference type="OMA" id="HWHEEAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024473">
        <property type="entry name" value="Transposases_IS4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13006">
        <property type="entry name" value="Nterm_IS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nterm_IS4" evidence="1">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="195" mass="22185" checksum="CC3C93F24992B3DC" modified="2005-12-06" version="1">MFPDFFMHIGQALDLASRYDSLRNPLTSLGDYLDPELISRCLAESGTVTLRKRRLPLEMMVWCIVGMVLERKEPLHQIVNRLDIMLPGNRPFVAPSAVIQARQRLGSEAVRRVFTKTAQLWHNATPHPHWCGLTLLAIDGVFWRTPDTPENDAAFPRQTHAGNPALYPQVKMVCQMDDQPSADGCSLRHDEEQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AI6</accession>
    <name>Q32AI6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bax</name>
        <name evidence="4" type="ordered locus">SDY_3709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378901.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405160.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AI6"/>
    <dbReference type="STRING" id="300267.SDY_3709"/>
    <dbReference type="CAZy" id="GH73">
        <property type="family name" value="Glycoside Hydrolase Family 73"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63669">
        <property type="protein sequence ID" value="ABB63669"/>
        <property type="gene ID" value="SDY_3709"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3709"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4403"/>
    <dbReference type="HOGENOM" id="CLU_061344_3_0_6"/>
    <dbReference type="OMA" id="NLFGQWC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220976" evidence="2">
        <location>
            <begin position="28"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="3">
        <location>
            <begin position="127"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="274" mass="30898" checksum="0A07C3400EEEFD3B" modified="2005-12-06" version="1">MILTPIRRYGAMILMLLTLVFSSEVLAKTHTTTASQKSHLTKASNKQVSSKQEYSRNSAKSSSLPDLRKYPSGTPRKKAFLRTVMPYITSQNAAITAERNWLISKQYQSQWSPAERARLKDIAKRYKVKWSGNTRKIPWNTLLERVDIIPTSMVATMAAAESGWGTSKLARNNNNLFGMKCMKGRCTNAPGKVKGYSQFSSVKESVSAYVTNLNTHPAYSSFRKSRAQLRKADQEVTATAMIHKLKGYSTKGKSYNNYLFAMYQDNQRLIAAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AK6</accession>
    <name>Q32AK6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yrfD</name>
        <name evidence="1" type="ordered locus">SDY_3684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AK6"/>
    <dbReference type="STRING" id="300267.SDY_3684"/>
    <dbReference type="EnsemblBacteria" id="ABB63649">
        <property type="protein sequence ID" value="ABB63649"/>
        <property type="gene ID" value="SDY_3684"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3684"/>
    <dbReference type="HOGENOM" id="CLU_1772143_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="148" mass="16225" checksum="C54DD7D950F1ECEC" modified="2005-12-06" version="1">MEPDSLRFDYSEDSLSPAYNVTAAQSKELATLLTLAERLRVHVSAITPDASALQRFLPFLPSHQQCLAWRDNEQWLWATRYRWGRKLAVGMTSAKELAAALSVDPASVAICGEGGFDPWEAVSVRQPPLPPPGGDFAIALGLALRKAY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B30</accession>
    <name>RS10_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsJ</name>
        <name type="ordered locus">SDY_3497</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001181004.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404966.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B30"/>
    <dbReference type="SMR" id="Q32B30"/>
    <dbReference type="STRING" id="300267.SDY_3497"/>
    <dbReference type="EnsemblBacteria" id="ABB63475">
        <property type="protein sequence ID" value="ABB63475"/>
        <property type="gene ID" value="SDY_3497"/>
    </dbReference>
    <dbReference type="GeneID" id="67415362"/>
    <dbReference type="KEGG" id="sdy:SDY_3497"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4150"/>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_6"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000237094" description="30S ribosomal protein S10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <sequence length="103" mass="11736" checksum="DAEB35A2557F1D59" modified="2005-12-06" version="1">MQNQRIRIRLKAFDHRLIDQATAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHLRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B41</accession>
    <name>RL14_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplN</name>
        <name type="ordered locus">SDY_3486</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000613955.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404955.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B41"/>
    <dbReference type="SMR" id="Q32B41"/>
    <dbReference type="STRING" id="300267.SDY_3486"/>
    <dbReference type="EnsemblBacteria" id="ABB63464">
        <property type="protein sequence ID" value="ABB63464"/>
        <property type="gene ID" value="SDY_3486"/>
    </dbReference>
    <dbReference type="GeneID" id="67415351"/>
    <dbReference type="KEGG" id="sdy:SDY_3486"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4139"/>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_6"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000266561" description="50S ribosomal protein L14">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <sequence length="123" mass="13541" checksum="192ACB1623979510" modified="2005-12-06" version="1">MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAPEVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B49</accession>
    <name>RL30_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmD</name>
        <name type="ordered locus">SDY_3478</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001140433.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404947.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B49"/>
    <dbReference type="SMR" id="Q32B49"/>
    <dbReference type="STRING" id="300267.SDY_3478"/>
    <dbReference type="EnsemblBacteria" id="ABB63456">
        <property type="protein sequence ID" value="ABB63456"/>
        <property type="gene ID" value="SDY_3478"/>
    </dbReference>
    <dbReference type="GeneID" id="67415343"/>
    <dbReference type="KEGG" id="sdy:SDY_3478"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4131"/>
    <dbReference type="HOGENOM" id="CLU_131047_1_4_6"/>
    <dbReference type="OMA" id="GKQNQRD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000273855" description="50S ribosomal protein L30">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <sequence length="59" mass="6542" checksum="08F427BBB6F820A4" modified="2005-12-06" version="1">MAKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAIRGMINAVSFMVKVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B90</accession>
    <name>Q32B90_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mreC</name>
        <name evidence="7" type="ordered locus">SDY_3425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000802516.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404906.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B90"/>
    <dbReference type="STRING" id="300267.SDY_3425"/>
    <dbReference type="EnsemblBacteria" id="ABB63415">
        <property type="protein sequence ID" value="ABB63415"/>
        <property type="gene ID" value="SDY_3425"/>
    </dbReference>
    <dbReference type="GeneID" id="66672855"/>
    <dbReference type="KEGG" id="sdy:SDY_3425"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4083"/>
    <dbReference type="HOGENOM" id="CLU_042663_2_0_6"/>
    <dbReference type="OMA" id="NPFTHRI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="367" mass="39560" checksum="0AAA7C4FF9E84C92" modified="2005-12-06" version="1">MKPIFSRGPSLQIRLILAVLVALGIIIADSRLGTFSQIRTYMDTAVSPFYFVSNAPRELLDGVSQTLASRDQLELENRALRQELLLKNSELLMLGQYKQENARLRELLGSPLRQDEQKMVTQVISTVNDPYSDQVVIDKGSVNGVYEGQPVISDKGVVGQVVAVAKLTSRVLLICDATHALPIQVLRNDIRVIAAGNGCTDDLQLEHLPANTDIRVGDVLVTSGLGGRFPEGYPVAVVSSVKLDTQRAYTVIQARPTAGLQRLRYLLLLWGADRNGANPMTPEEVHRVANERLMQMMPQVLPSPDAMGPKLPEPATGIAQPTPQQPTTGNAATAPAAPTQPAANRSPQRATPPQSGAQPPARAPGGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B97</accession>
    <name>AAEX_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AaeX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aaeX</name>
        <name type="ordered locus">SDY_3418</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AaeX family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63408" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63408.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000051841.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404899.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B97"/>
    <dbReference type="STRING" id="300267.SDY_3418"/>
    <dbReference type="EnsemblBacteria" id="ABB63408">
        <property type="protein sequence ID" value="ABB63408"/>
        <property type="gene ID" value="SDY_3418"/>
    </dbReference>
    <dbReference type="GeneID" id="67415926"/>
    <dbReference type="KEGG" id="sdy:SDY_3418"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4076"/>
    <dbReference type="HOGENOM" id="CLU_188292_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01546">
        <property type="entry name" value="AaeX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012451">
        <property type="entry name" value="DUF1656"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07869">
        <property type="entry name" value="DUF1656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000300577" description="Protein AaeX">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="67" mass="7847" checksum="FE90E26EC56C9183" modified="2007-09-11" version="2">MSLFPVIVVFGLSFPPIFFELLLSLAIFWLVRRVLVPTGIYDFVWHPALFNTALYCCLFYLISRLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BE6</accession>
    <name>Q32BE6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Octaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ispB</name>
        <name evidence="3" type="ordered locus">SDY_3368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018818.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404850.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BE6"/>
    <dbReference type="STRING" id="300267.SDY_3368"/>
    <dbReference type="EnsemblBacteria" id="ABB63359">
        <property type="protein sequence ID" value="ABB63359"/>
        <property type="gene ID" value="SDY_3368"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3368"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4022"/>
    <dbReference type="HOGENOM" id="CLU_014015_2_0_6"/>
    <dbReference type="OMA" id="GKQMRPM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="323" mass="35231" checksum="552FE768AC3C06F3" modified="2005-12-06" version="1">MNLEKINELTAQDMAGVNAAILEQLNSDVQLINQLGYYIVSGGGKRIRPMIAVLAARAVGYEGNAHVTIAALIEFIHTATLLHDDVVDESDMRRGKATANAAFGNAASVLVGDFIYTRAFQMMTSLGSLKVLEVMSEAVNIIAEGEVLQLMNVNDPDITEENYMRVIYSKTARLFEAAAQCSGILAGCTPEEEKGLQDYGRYLGTAFQLIDDLLDYNADGEQLGKNVGDDLNEGKPTLPLLHAMHHGTPEQAQMIRTAIEQGNGRHLLEPVLEAMNACGSLEWTRQRAEEEADKAIAALQVLPDTPWREALIGLAHIAVQRDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BE8</accession>
    <name>RL27_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmA</name>
        <name type="ordered locus">SDY_3366</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000940595.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404848.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BE8"/>
    <dbReference type="SMR" id="Q32BE8"/>
    <dbReference type="STRING" id="300267.SDY_3366"/>
    <dbReference type="EnsemblBacteria" id="ABB63357">
        <property type="protein sequence ID" value="ABB63357"/>
        <property type="gene ID" value="SDY_3366"/>
    </dbReference>
    <dbReference type="GeneID" id="66672913"/>
    <dbReference type="KEGG" id="sdy:SDY_3366"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4020"/>
    <dbReference type="HOGENOM" id="CLU_095424_4_1_6"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000017608" description="50S ribosomal protein L27">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="85" mass="9124" checksum="B43AAE180ABC23EA" modified="2005-12-06" version="1">MAHKKAGGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVGCGRDHTLFAKADGKVKFEVKGPKNRKFISIEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BF3</accession>
    <name>Q32BF3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yhbY</name>
        <name evidence="4" type="ordered locus">SDY_3361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001054419.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404843.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BF3"/>
    <dbReference type="STRING" id="300267.SDY_3361"/>
    <dbReference type="EnsemblBacteria" id="ABB63352">
        <property type="protein sequence ID" value="ABB63352"/>
        <property type="gene ID" value="SDY_3361"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3361"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4015"/>
    <dbReference type="HOGENOM" id="CLU_095994_2_0_6"/>
    <dbReference type="OMA" id="FQVGKNG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017924">
        <property type="entry name" value="RNA-binding_YhbY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00253">
        <property type="entry name" value="RNA_bind_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="97" mass="10765" checksum="4754F7AD4C203382" modified="2005-12-06" version="1">MNLSTKQKQHLKGLAHPLKPVVLLGSNGLTEGVLAEIEQALEHHELIKVKIATEDRETKTLIVEAIVRETGACNVQVIGKTLVLYRPTKERKISLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BG0</accession>
    <name>Q32BG0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BG0"/>
    <dbReference type="STRING" id="300267.SDY_3353"/>
    <dbReference type="EnsemblBacteria" id="ABB63345">
        <property type="protein sequence ID" value="ABB63345"/>
        <property type="gene ID" value="SDY_3353"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3353"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_2_6"/>
    <dbReference type="OMA" id="FIEREHC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="62" mass="7316" checksum="DD641DC2EAD2E4B5" modified="2005-12-06" version="1">MAGGVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BG2</accession>
    <name>ASSY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate synthase</fullName>
            <ecNumber evidence="1">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argG</name>
        <name type="ordered locus">SDY_3351</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the argininosuccinate synthase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000207673.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404834.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BG2"/>
    <dbReference type="SMR" id="Q32BG2"/>
    <dbReference type="STRING" id="300267.SDY_3351"/>
    <dbReference type="EnsemblBacteria" id="ABB63343">
        <property type="protein sequence ID" value="ABB63343"/>
        <property type="gene ID" value="SDY_3351"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3351"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4004"/>
    <dbReference type="HOGENOM" id="CLU_032784_4_1_6"/>
    <dbReference type="OMA" id="QCEVVTF"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00581">
        <property type="entry name" value="Arg_succ_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023437">
        <property type="entry name" value="Arg_succ_synth_type2_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024073">
        <property type="entry name" value="AS_multimer_C_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000025442" description="Argininosuccinate synthase">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00581"/>
        </source>
    </evidence>
    <sequence length="447" mass="49911" checksum="C8402FA1A0A4A273" modified="2005-12-06" version="1">MTTILKHLPVGQRIGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEEDYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELQIYKPWLDTDFIDELGGRHEMSEFMIACGFDYKMSVEKAYSTDSNMLGATHEAKDLEYLNSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNGKTFSDDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDSQALMLRDSLQRWVASQITGEVTLELRHGNDYSILNTVSENLTYKPERLTMEKGDSVFSPDDRIGQLTMRNLDITDTREKLFGYAKTGLLSSSAASGVPQMENLENKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BI7</accession>
    <name>Q32BI7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fimbrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yraK</name>
        <name evidence="3" type="ordered locus">SDY_3324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000817009.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404809.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BI7"/>
    <dbReference type="STRING" id="300267.SDY_3324"/>
    <dbReference type="EnsemblBacteria" id="ABB63318">
        <property type="protein sequence ID" value="ABB63318"/>
        <property type="gene ID" value="SDY_3324"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3324"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3977"/>
    <dbReference type="HOGENOM" id="CLU_066608_0_0_6"/>
    <dbReference type="OMA" id="TIACNCT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000259">
        <property type="entry name" value="Adhesion_dom_fimbrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00419">
        <property type="entry name" value="Fimbrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220865" evidence="1">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Fimbrial" evidence="2">
        <location>
            <begin position="216"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="363" mass="38668" checksum="029F0C0021C9F726" modified="2005-12-06" version="1">MKRAPLITGLLLISTSCAYASSGGCGADSTSGATNYSSVVDDVTVNQTDNVTGREFTSATLSSTNWQYDCSCSAGKAVKLVYMVSPVLTTTGHQTGYYKLNDSLDIKTTLQANDIPGLTTDQVVSVNTRFTQIKSSTVYSAATQTGVCQGDTSRYGPVNIGANTTFTLYVTKPFLGSMTIPKTDIAVIKGAWVDGMGSPSTGDFHDLVKLSIQENLTAPQSCKINQGDVIKVNFGFINGQKFTTRNAMPDGFTPVDFDITYDCGDTSKIKNSLQMRIDGTTGVVDQYNLVARRRSSDNAPDVGIRIENLGGRVANIPFQNGILPVDPSGHGTVNMRAWPVNLVGGELETGKFQGTATITVIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BJ1</accession>
    <name>Q32BJ1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-hydroxy-3-oxopropionate reductase</fullName>
            <ecNumber evidence="2">1.1.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Tartronate semialdehyde reductase</fullName>
            <shortName evidence="2">TSAR</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhaE</name>
        <name evidence="2" type="synonym">garR</name>
        <name evidence="6" type="ordered locus">SDY_3319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of tatronate semialdehyde to D-glycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16659"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57978"/>
            <dbReference type="EC" id="1.1.1.60"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16659"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57978"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism; galactarate degradation; D-glycerate from galactarate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 2-hydroxy-3-oxopropionate reductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.60" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BJ1"/>
    <dbReference type="STRING" id="300267.SDY_3319"/>
    <dbReference type="EnsemblBacteria" id="ABB63314">
        <property type="protein sequence ID" value="ABB63314"/>
        <property type="gene ID" value="SDY_3319"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3319"/>
    <dbReference type="HOGENOM" id="CLU_035117_1_0_6"/>
    <dbReference type="OMA" id="AWVQSTT"/>
    <dbReference type="UniPathway" id="UPA00565">
        <property type="reaction ID" value="UER00631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103032">
        <property type="term" value="F:tartronate semialdehyde reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046392">
        <property type="term" value="P:galactarate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02032">
        <property type="entry name" value="Tartronate_sem_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006398">
        <property type="entry name" value="Tartro_sem_red"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01505">
        <property type="entry name" value="tartro_sem_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="5">
        <location>
            <begin position="169"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="299" mass="31099" checksum="09E74B2F02072E22" modified="2005-12-06" version="1">MIDMTMKVGFIGLGIMGKTMSKNLLKAGYSLVVADRNPEAIADVIAAGAETASTAKAIAEQCDVIITMLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISEALKAKGIDMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGEIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAMRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIKDLANELDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKVEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BQ1</accession>
    <name>Q32BQ1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">dnaG</name>
        <name evidence="14" type="ordered locus">SDY_3250</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000918829.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404745.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BQ1"/>
    <dbReference type="STRING" id="300267.SDY_3250"/>
    <dbReference type="EnsemblBacteria" id="ABB63254">
        <property type="protein sequence ID" value="ABB63254"/>
        <property type="gene ID" value="SDY_3250"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3250"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3884"/>
    <dbReference type="HOGENOM" id="CLU_013501_5_4_6"/>
    <dbReference type="OMA" id="LMWPIRD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013173">
        <property type="entry name" value="DNA_primase_DnaG_DnaB-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08278">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00766">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="13">
        <location>
            <begin position="259"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB63254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="581" mass="65595" checksum="784DF020FBD82D88" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BT2</accession>
    <name>Q32BT2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 2-component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ygiX</name>
        <name evidence="5" type="ordered locus">SDY_3214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001221504.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404714.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BT2"/>
    <dbReference type="STRING" id="300267.SDY_3214"/>
    <dbReference type="EnsemblBacteria" id="ABB63223">
        <property type="protein sequence ID" value="ABB63223"/>
        <property type="gene ID" value="SDY_3214"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3214"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3839"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_6"/>
    <dbReference type="OMA" id="SYPRRVW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="24776" checksum="8CB5946C4CF7AC8A" modified="2005-12-06" version="1">MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTARDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQTSNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLELLMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BV9</accession>
    <name>Q32BV9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000244779.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404687.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BV9"/>
    <dbReference type="STRING" id="300267.SDY_3186"/>
    <dbReference type="EnsemblBacteria" id="ABB63196">
        <property type="protein sequence ID" value="ABB63196"/>
        <property type="gene ID" value="SDY_3186"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3186"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3808"/>
    <dbReference type="HOGENOM" id="CLU_153203_0_0_6"/>
    <dbReference type="OMA" id="WLASDSM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009883">
        <property type="entry name" value="YgfX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07254">
        <property type="entry name" value="Cpta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020653">
        <property type="entry name" value="UCP020653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="16094" checksum="CB3969F10AAD1D98" modified="2005-12-06" version="1">MVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQEWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRWILLQQETQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BY8</accession>
    <name>Q32BY8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000988700.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404658.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BY8"/>
    <dbReference type="SMR" id="Q32BY8"/>
    <dbReference type="STRING" id="300267.SDY_3154"/>
    <dbReference type="EnsemblBacteria" id="ABB63167">
        <property type="protein sequence ID" value="ABB63167"/>
        <property type="gene ID" value="SDY_3154"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3154"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3766"/>
    <dbReference type="HOGENOM" id="CLU_114051_3_1_6"/>
    <dbReference type="OMA" id="HLHMSVA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="143" mass="15537" checksum="22916BD5B25147A3" modified="2005-12-06" version="1">MMTLPYPYSSSARFYALRLLPGQEVFSQLHAFAQQQQLHAAWIAGCTGSLTDIALRYAGQEGTTLLNGTFEVISLNGTLEQSGEHLHLCVSDPHGTMLGGHMMPGCTVRTTLELVIGSLEELAFSRQPCALSGYDELHISPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C70</accession>
    <name>Q32C70_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Biopolymer transport protein ExbD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">exbD</name>
        <name evidence="14" type="ordered locus">SDY_3068</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The accessory proteins ExbB and ExbD seem to form a complex with TonB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001240711.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404576.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C70"/>
    <dbReference type="STRING" id="300267.SDY_3068"/>
    <dbReference type="EnsemblBacteria" id="ABB63085">
        <property type="protein sequence ID" value="ABB63085"/>
        <property type="gene ID" value="SDY_3068"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3068"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3673"/>
    <dbReference type="HOGENOM" id="CLU_085305_1_3_6"/>
    <dbReference type="OMA" id="TQGKKDT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014170">
        <property type="entry name" value="TonB_ExbD_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02803">
        <property type="entry name" value="ExbD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB63085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="141" mass="15587" checksum="354B3752FAFE455C" modified="2005-12-06" version="1">MAMHLNENLDDNGEMHDINVTPFIDVMLVLLIIFMVAAPLATVDVKVNLPASTSTPQPRPEKPVYLSVKADNSMFIGNDPVTDETMITALNALTEGKKDTTIFFRADKIVDYETLMKVMYTLHQAGYLKIGLVGEETAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C84</accession>
    <name>Q32C84_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Repressor of galETK operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">galR</name>
        <name evidence="5" type="ordered locus">SDY_3054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000201064.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404562.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C84"/>
    <dbReference type="STRING" id="300267.SDY_3054"/>
    <dbReference type="EnsemblBacteria" id="ABB63071">
        <property type="protein sequence ID" value="ABB63071"/>
        <property type="gene ID" value="SDY_3054"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3054"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3659"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_6"/>
    <dbReference type="OMA" id="CVAVDFR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="343" mass="37120" checksum="4DE04AC8A2476F3F" modified="2005-12-06" version="1">MATIKDVARLAGVSVATVSRVINNSPKASEASRLAVHSAMESLSYHPNANARALAQQTTETVGLVVGDVSDPFFGAMVKAVEQVAYHTGNFLLIGNGYHNEQKERQAIEQLIRHRCAALVVHAKMIPDADLASLMKQMPGMVLINRILPGFENRCIALDDRYGAWLATRHLIQQGHTRIGYLCSNHSISDAEDRLQGYYDALAESGIPANDRLVTFGEPDESGGEQAMTELLGRGRNFTAVACYNDSMAAGAMGVLNDNGIDVPGEISLIGFDDVLVSRYVRPRLTTVRYPIVTMATQAAELALALADNRPLPEITNVFSPTLVRRHSVSTPSLEASHHATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CC6</accession>
    <name>Q32CC6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF446 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000206995.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404520.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CC6"/>
    <dbReference type="SMR" id="Q32CC6"/>
    <dbReference type="STRING" id="300267.SDY_3009"/>
    <dbReference type="EnsemblBacteria" id="ABB63029">
        <property type="protein sequence ID" value="ABB63029"/>
        <property type="gene ID" value="SDY_3009"/>
    </dbReference>
    <dbReference type="GeneID" id="58459976"/>
    <dbReference type="KEGG" id="sdy:SDY_3009"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3613"/>
    <dbReference type="HOGENOM" id="CLU_130358_0_0_6"/>
    <dbReference type="OMA" id="FIPRMYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007384">
        <property type="entry name" value="UCP006257"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023376">
        <property type="entry name" value="YqcC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036814">
        <property type="entry name" value="YqcC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39586">
        <property type="entry name" value="PTHR39586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04287">
        <property type="entry name" value="DUF446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006257">
        <property type="entry name" value="UCP006257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158452">
        <property type="entry name" value="SSF158452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF446" evidence="1">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="109" mass="12771" checksum="E04FA6B44A51D245" modified="2005-12-06" version="1">MTTHDRVRLQLQALEALLREHQHWRNDEPQPHQFNSTQPFFMDTMEPLEWLQWVLIPRMHDLLNNNQPLPGAFAVAPYYEMALATDHPQRALILAELEKLDALFADDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CD1</accession>
    <name>Q32CD1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(P)ppGpp synthetase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">relA</name>
        <name evidence="6" type="ordered locus">SDY_3001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000226815.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404515.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CD1"/>
    <dbReference type="SMR" id="Q32CD1"/>
    <dbReference type="STRING" id="300267.SDY_3001"/>
    <dbReference type="EnsemblBacteria" id="ABB63024">
        <property type="protein sequence ID" value="ABB63024"/>
        <property type="gene ID" value="SDY_3001"/>
    </dbReference>
    <dbReference type="GeneID" id="66673349"/>
    <dbReference type="KEGG" id="sdy:SDY_3001"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3600"/>
    <dbReference type="HOGENOM" id="CLU_012300_3_0_6"/>
    <dbReference type="OMA" id="TEIGHNC"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
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        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="55"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="404"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="668"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="744" mass="83876" checksum="FA269709F15E1F25" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CF9</accession>
    <name>Q32CF9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative anti-terminator regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ygcP</name>
        <name evidence="1" type="ordered locus">SDY_2970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001116197.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404487.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CF9"/>
    <dbReference type="STRING" id="300267.SDY_2970"/>
    <dbReference type="EnsemblBacteria" id="ABB62996">
        <property type="protein sequence ID" value="ABB62996"/>
        <property type="gene ID" value="SDY_2970"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2970"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3562"/>
    <dbReference type="HOGENOM" id="CLU_111516_0_2_6"/>
    <dbReference type="OMA" id="PAIRNMK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006699">
        <property type="entry name" value="GlpP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35787">
        <property type="entry name" value="PTHR35787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04309">
        <property type="entry name" value="G3P_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016897">
        <property type="entry name" value="GlpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="191" mass="20820" checksum="58A27BE8ECFC93A7" modified="2005-12-06" version="1">MPFLHLLRQNPVIAAVKDNASLQLAIDSECQFISVLYGNICTISNIVKKIKNAGKYAFIHVDLLEGASNKEVVIQFLKLVTEADGIISTKASMLKAARAEGFFCIHRLFIVDSISFHNIDKQVAQSNPDCIEILPGCMPKVLGWVTEKIRQPLIAGGLVCDEEDARNAINAGVVALSTTNTGVWTLAKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CL6</accession>
    <name>Q32CL6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbamoyltransferase HypF</fullName>
            <ecNumber evidence="8">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hypF</name>
        <name evidence="12" type="ordered locus">SDY_2909</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019670.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404430.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CL6"/>
    <dbReference type="STRING" id="300267.SDY_2909"/>
    <dbReference type="EnsemblBacteria" id="ABB62939">
        <property type="protein sequence ID" value="ABB62939"/>
        <property type="gene ID" value="SDY_2909"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2909"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3494"/>
    <dbReference type="HOGENOM" id="CLU_009164_0_0_6"/>
    <dbReference type="OMA" id="VQHHYAH"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="10">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="11">
        <location>
            <begin position="200"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="750" mass="82101" checksum="21A234D9BFE24591" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CL8</accession>
    <name>NORV_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaerobic nitric oxide reductase flavorubredoxin</fullName>
            <shortName evidence="1">FlRd</shortName>
            <shortName evidence="1">FlavoRb</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">norV</name>
        <name evidence="1" type="synonym">flrD</name>
        <name type="ordered locus">SDY_2907</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 3 Fe cations per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; nitric oxide reduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000029641.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404428.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CL8"/>
    <dbReference type="SMR" id="Q32CL8"/>
    <dbReference type="STRING" id="300267.SDY_2907"/>
    <dbReference type="EnsemblBacteria" id="ABB62937">
        <property type="protein sequence ID" value="ABB62937"/>
        <property type="gene ID" value="SDY_2907"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2907"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3492"/>
    <dbReference type="HOGENOM" id="CLU_017490_0_1_6"/>
    <dbReference type="OMA" id="HVKNNIH"/>
    <dbReference type="UniPathway" id="UPA00638"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016966">
        <property type="term" value="F:nitric oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01312">
        <property type="entry name" value="NorV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023957">
        <property type="entry name" value="Anaer_NO_rdtase_flvorubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000305598" description="Anaerobic nitric oxide reductase flavorubredoxin">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="254"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="423"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Zinc metallo-hydrolase">
        <location>
            <begin position="30"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01312"/>
        </source>
    </evidence>
    <sequence length="479" mass="54265" checksum="75EA9BAC6678F466" modified="2005-12-06" version="1">MSIVVKNNIHWVGQRDWEVRDFHGTEYKTLRGSSYNSYLIREEKNVLIDTVDHKFSREFVQNLRNEIDLADIDYIVINHAEEDHAGALTELMAQIPDTPIYCTANAIDSINGHHHHPEWNFNVVKTGDTLDIGNGKQLIFVETPMLHWPDSMMTYLTGDAVLFSNDAFGQHYCDEHLFNDEVDQTELFEQCQRYYSNILTPFSRLVTPKITEILGFNLPVDMIATSHGVVWRDNPTQIVELYLKWAADYQEDRITIFYDTMSNNTRMMADAIAQGIAETDPRVAVKIFNIARSDKNEILTNVFRSKGVLVGTSTMNNVMMPKIAGLVEEMTGLRFRNKRASAFGSHGWSGGAVDRLSTRLQDAGFEMSLSLKAKWRPDQDALELCREHGREIARQWALAPLPQSTVNTVVKEETSATTTADLGPRMQCSVCQWIYDPAKGEPMQDVAPGTPWSEVPDNFLCPECSLGKDVFEELASEAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CN2</accession>
    <name>CSRA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translational regulator CsrA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Carbon storage regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csrA</name>
        <name type="ordered locus">SDY_2892</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000906486.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404414.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CN2"/>
    <dbReference type="SMR" id="Q32CN2"/>
    <dbReference type="STRING" id="300267.SDY_2892"/>
    <dbReference type="EnsemblBacteria" id="ABB62923">
        <property type="protein sequence ID" value="ABB62923"/>
        <property type="gene ID" value="SDY_2892"/>
    </dbReference>
    <dbReference type="GeneID" id="64727209"/>
    <dbReference type="GeneID" id="67517504"/>
    <dbReference type="KEGG" id="sdy:SDY_2892"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3473"/>
    <dbReference type="HOGENOM" id="CLU_164837_2_1_6"/>
    <dbReference type="OMA" id="IHRKEVY"/>
    <dbReference type="PRO" id="PR:Q32CN2"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_1000023427" description="Translational regulator CsrA">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <sequence length="61" mass="6856" checksum="16308FC572670E1C" modified="2005-12-06" version="1">MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQAEKSQQSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CU4</accession>
    <name>Q32CU4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator LYSR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yfiE</name>
        <name evidence="3" type="ordered locus">SDY_2818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404352.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CU4"/>
    <dbReference type="STRING" id="300267.SDY_2818"/>
    <dbReference type="EnsemblBacteria" id="ABB62861">
        <property type="protein sequence ID" value="ABB62861"/>
        <property type="gene ID" value="SDY_2818"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2818"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3394"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_6"/>
    <dbReference type="OMA" id="ACEEYFK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="308" mass="35228" checksum="07A075A8B7C71EAA" modified="2005-12-06" version="1">MFLHSKFDIFDRFGVMDLRRFITLKTVVEEGSFLRASQKLCCTQSTVTFHIQQLEQEFSVQLFEKIGRRMCFTREGKKLLPHIYELTRVMDTLREAAKKESDPDGELRVVSGETLLSYRMLQVLQRFRQRAPKVRLSLQSLNCYVIRDALLNDEADVGVFYRVGNDDALNRRELGEQSLVLVASPQIADVDFTEPGRHNACSFIINEPQCVFRQIFESTLRQRRITVENTIELLSIESIKRCVAANIGVSYLPRFAVEKELESGELIELPFGEHSQTITAMCAHHAGKAVSPAMHTFIQCVEDCFLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CV3</accession>
    <name>Q32CV3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Signal peptidase I</fullName>
            <ecNumber evidence="4 8">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lepB</name>
        <name evidence="11" type="ordered locus">SDY_2809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000002535.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404343.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CV3"/>
    <dbReference type="STRING" id="300267.SDY_2809"/>
    <dbReference type="MEROPS" id="S26.001"/>
    <dbReference type="EnsemblBacteria" id="ABB62852">
        <property type="protein sequence ID" value="ABB62852"/>
        <property type="gene ID" value="SDY_2809"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2809"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3384"/>
    <dbReference type="HOGENOM" id="CLU_028723_1_1_6"/>
    <dbReference type="OMA" id="SDSRFWG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019766">
        <property type="entry name" value="Sign_pep_all-beta_subdom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="10">
        <location>
            <begin position="60"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="324" mass="35962" checksum="84B5290C6212F761" modified="2005-12-06" version="1">MANMFALILVIATLVTGILWCVDKFFFAPKRRERQAAAQAAAGDSLDKATLKKVAPKPGWLETGASVFPVLAIVLIVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPIYQKTLIETGHPKRGDIVVFKYPEDPKLDYIKRAVGLPGDKVTYDPVSKELTIQPGCCSGQACENALPVTYSNVEPSDFVQTFSRRNGGEATSGFFEVPKNETKENGIRLSERKETLGDVTHRILTVPIAQDQVGMYYQQPGQQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAIWMSFDKQEGEWPTGVRLSRIGGIH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CY0</accession>
    <name>RIMM_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimM</name>
        <name type="ordered locus">SDY_2782</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CY0"/>
    <dbReference type="SMR" id="Q32CY0"/>
    <dbReference type="STRING" id="300267.SDY_2782"/>
    <dbReference type="EnsemblBacteria" id="ABB62825">
        <property type="protein sequence ID" value="ABB62825"/>
        <property type="gene ID" value="SDY_2782"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2782"/>
    <dbReference type="HOGENOM" id="CLU_077636_1_0_6"/>
    <dbReference type="OMA" id="DEFYHAD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000244167" description="Ribosome maturation factor RimM">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PRC barrel" evidence="1">
        <location>
            <begin position="106"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <sequence length="185" mass="20967" checksum="4E5E0816C90D5F5A" modified="2005-12-06" version="1">MVMMSKQLTAQAPVDPIVLGKMGSSYGIRGWLRVFSSTEDAESIFDYQPWFIQKAGQWQQVQLESWKHHNQDMIIKLKGVDDRDAANLLTNCEIVVDSSQLPQLEEGDYYWKDLMGCQVVTTEGYDLGKVVDMMETGSNDVLVIKANLKDAFGIKERLVPFLDGQVIKKVDLTTRSIEVDWDPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D35</accession>
    <name>Q32D35_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Iron-sulfur cluster assembly scaffold protein IscU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_2725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000331707.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404261.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D35"/>
    <dbReference type="SMR" id="Q32D35"/>
    <dbReference type="STRING" id="300267.SDY_2725"/>
    <dbReference type="EnsemblBacteria" id="ABB62770">
        <property type="protein sequence ID" value="ABB62770"/>
        <property type="gene ID" value="SDY_2725"/>
    </dbReference>
    <dbReference type="GeneID" id="67416913"/>
    <dbReference type="KEGG" id="sdy:SDY_2725"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3287"/>
    <dbReference type="HOGENOM" id="CLU_079283_5_0_6"/>
    <dbReference type="OMA" id="YKNPRNY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISC_FeS_clus_asmbl_IscU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="128" mass="13849" checksum="47516021442B6535" modified="2005-12-06" version="1">MAYSEKVIDHYENPRNVGSFDNNDENVGSGMVGAPACGDVMKLQIKVNDEGIIEDARFKTYGCGSAIASSSLVTEWVKGKSLDEAQAIKNTDIAEELELPPVKIHCSILAEDAIKAAIADYKSKREAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D58</accession>
    <name>Q32D58_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D58"/>
    <dbReference type="EnsemblBacteria" id="ABB62747">
        <property type="protein sequence ID" value="ABB62747"/>
        <property type="gene ID" value="SDY_2700"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2700"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="FALECCD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32044" checksum="8B5A57CF85D2CAC9" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALECCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DH9</accession>
    <name>Q32DH9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-serine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404117.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DH9"/>
    <dbReference type="STRING" id="300267.SDY_2560"/>
    <dbReference type="EnsemblBacteria" id="ABB62626">
        <property type="protein sequence ID" value="ABB62626"/>
        <property type="gene ID" value="SDY_2560"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2560"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3084"/>
    <dbReference type="HOGENOM" id="CLU_027949_2_2_6"/>
    <dbReference type="OMA" id="PFLAPML"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="7740" checksum="DF3375DA6608A5CC" modified="2005-12-06" version="1">MLPLYPDISPEIIAIAIGSGAIGCTIVTDSLFWLVKQYCGATLNETFKYYTTATFIASVVALAGTFLLSFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DI5</accession>
    <name>Q32DI5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yfdC</name>
        <name evidence="7" type="ordered locus">SDY_2551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000368131.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404111.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DI5"/>
    <dbReference type="STRING" id="300267.SDY_2551"/>
    <dbReference type="EnsemblBacteria" id="ABB62620">
        <property type="protein sequence ID" value="ABB62620"/>
        <property type="gene ID" value="SDY_2551"/>
    </dbReference>
    <dbReference type="GeneID" id="66673771"/>
    <dbReference type="KEGG" id="sdy:SDY_2551"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3071"/>
    <dbReference type="HOGENOM" id="CLU_061519_1_0_6"/>
    <dbReference type="OMA" id="GWMIATM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="310" mass="34482" checksum="407D21FFF665D690" modified="2005-12-06" version="1">MDNDKIDQHSDEIEVESEEKERGKKIEIDEDRLPSRAMAIHEHIRQDGEKELERDAMALLWSAIAAGLSMGASLLAKGIFHVELEGVPGSFLLENLGYTFGFIIVIMARQQLFTENTVTAVLPVMQKPTMSNVGLLMRLWGVVLLGNILGTGIAAWAFEYMPIFNEETRDAFVKIGMDVMKNTPSEMFANAIISGWLIATMVWMFPAAGAAKIVVIILMTWLIALGDTTHIVVGSVEILYLVFNGTLHWSDFIWPFALPTLAGNICGGTFIFALMSHAQIRNDMSNKRKAEARQKAERAENIKKNDKNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DN8</accession>
    <name>Q32DN8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST_C_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DN8"/>
    <dbReference type="STRING" id="300267.SDY_2497"/>
    <dbReference type="EnsemblBacteria" id="ABB62567">
        <property type="protein sequence ID" value="ABB62567"/>
        <property type="gene ID" value="SDY_2497"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2497"/>
    <dbReference type="HOGENOM" id="CLU_153101_0_0_6"/>
    <dbReference type="OMA" id="FSPYVMS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd03195">
        <property type="entry name" value="GST_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034338">
        <property type="entry name" value="GST_4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14834">
        <property type="entry name" value="GST_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST_C_4" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="106" mass="11799" checksum="1B2E15E0C68B5D50" modified="2005-12-06" version="1">MRSDLMPIREERPTDVVFAGAKKAPLTAEGKASAEKLFAMAEHLLVLGQPNLFGEWCIADTDLALMINRLVLHGDEVPERLVDYATFQWQRASVQRFIALSAKQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DV2</accession>
    <name>Q32DV2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfaE</name>
        <name evidence="2" type="ordered locus">SDY_2430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000124825.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403994.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DV2"/>
    <dbReference type="STRING" id="300267.SDY_2430"/>
    <dbReference type="EnsemblBacteria" id="ABB62503">
        <property type="protein sequence ID" value="ABB62503"/>
        <property type="gene ID" value="SDY_2430"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2430"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2928"/>
    <dbReference type="HOGENOM" id="CLU_082632_6_1_6"/>
    <dbReference type="OMA" id="YCGSCRC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="9305" checksum="AC344834F4AE1D60" modified="2005-12-06" version="1">MARVILRITGTQLLCQDEHPSLLAALESHNVAVEYQCREGYCGSCRTRLVAGQVDWIAEPLAFIQPGEILPCCCRAKGDIEIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DV7</accession>
    <name>Q32DV7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yfaL</name>
        <name evidence="4" type="ordered locus">SDY_2425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DV7"/>
    <dbReference type="STRING" id="300267.SDY_2425"/>
    <dbReference type="EnsemblBacteria" id="ABB62498">
        <property type="protein sequence ID" value="ABB62498"/>
        <property type="gene ID" value="SDY_2425"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2425"/>
    <dbReference type="HOGENOM" id="CLU_386733_0_0_6"/>
    <dbReference type="OMA" id="AIWMSEL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01344">
        <property type="entry name" value="PL2_Passenger_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043990">
        <property type="entry name" value="AC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005546">
        <property type="entry name" value="Autotransporte_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036709">
        <property type="entry name" value="Autotransporte_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013425">
        <property type="entry name" value="Autotrns_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006315">
        <property type="entry name" value="OM_autotransptr_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18883">
        <property type="entry name" value="AC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03797">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12951">
        <property type="entry name" value="PATR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00869">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103515"/>
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    </dbReference>
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        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01414">
        <property type="entry name" value="autotrans_barl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02601">
        <property type="entry name" value="autotrns_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51208">
        <property type="entry name" value="AUTOTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Autotransporter" evidence="3">
        <location>
            <begin position="450"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="720" mass="76535" checksum="C5786B906DB7EE29" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DX2</accession>
    <name>Q32DX2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403974.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DX2"/>
    <dbReference type="EnsemblBacteria" id="ABB62483">
        <property type="protein sequence ID" value="ABB62483"/>
        <property type="gene ID" value="SDY_2410"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2410"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2907"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="PGHRIYP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="269" mass="31151" checksum="7297F73320FCF48E" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQSGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSKPAGNYWHCLRHSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DZ6</accession>
    <name>Q32DZ6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Toprim domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybjD</name>
        <name evidence="2" type="ordered locus">SDY_2385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000599782.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403950.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DZ6"/>
    <dbReference type="STRING" id="300267.SDY_2385"/>
    <dbReference type="EnsemblBacteria" id="ABB62459">
        <property type="protein sequence ID" value="ABB62459"/>
        <property type="gene ID" value="SDY_2385"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2385"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2878"/>
    <dbReference type="HOGENOM" id="CLU_034845_0_0_6"/>
    <dbReference type="OMA" id="MNMRRVI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01026">
        <property type="entry name" value="TOPRIM_OLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022602">
        <property type="entry name" value="DUF2813"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034139">
        <property type="entry name" value="TOPRIM_OLD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11398">
        <property type="entry name" value="DUF2813"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="379"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="552" mass="63518" checksum="5305FD600182458D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DZ8</accession>
    <name>Q32DZ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_2383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DZ8"/>
    <dbReference type="STRING" id="300267.SDY_2383"/>
    <dbReference type="EnsemblBacteria" id="ABB62457">
        <property type="protein sequence ID" value="ABB62457"/>
        <property type="gene ID" value="SDY_2383"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2383"/>
    <dbReference type="HOGENOM" id="CLU_018816_14_1_6"/>
    <dbReference type="OMA" id="TGKIQPE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990195">
        <property type="term" value="C:macrolide transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030190">
        <property type="entry name" value="MacA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30469:SF34">
        <property type="entry name" value="PTHR30469:SF34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="56"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="358" mass="39140" checksum="0B5CD4CB98A32350" modified="2005-12-06" version="1">MAYGVFRIFMKKRKTVKKRYVIALVIVIAGLITLWRILNAPVPTYQTLIVRPGDLQQSVLATGKLDALRKVDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPEQAENQIKEVEATLMELRAQRQQAEAELKLARVTYSRQQRLAQTQAVSQQDLDTAAMEMAVKQAQIGTIDAQIKRNQASLDTAKTNLDYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLKPGQKAWFTVLGDPLTRYEGQIKDVLPTPEKVNDAIFYYARFEVPNPNGLLRLDMTAQVHIQLTDVKNVLTIPLSALGDPVGARNDTDVEIVKGLEAGDEVVIGEAKPGAAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E04</accession>
    <name>LFTR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucyl/phenylalanyl-tRNA--protein transferase</fullName>
            <ecNumber evidence="1">2.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L/F-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Leucyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phenyalanyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aat</name>
        <name type="ordered locus">SDY_2376</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:12340"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12670"/>
            <dbReference type="Rhea" id="RHEA-COMP:12671"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:65249"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133043"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:50416"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12673"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64719"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133044"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:43632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10637"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83561"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the L/F-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001241684.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403942.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E04"/>
    <dbReference type="SMR" id="Q32E04"/>
    <dbReference type="STRING" id="300267.SDY_2376"/>
    <dbReference type="EnsemblBacteria" id="ABB62451">
        <property type="protein sequence ID" value="ABB62451"/>
        <property type="gene ID" value="SDY_2376"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2376"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2870"/>
    <dbReference type="HOGENOM" id="CLU_075045_0_0_6"/>
    <dbReference type="OMA" id="YRQGIFP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00688">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042221">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="PTHR30098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00667">
        <property type="entry name" value="aat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000258099" description="Leucyl/phenylalanyl-tRNA--protein transferase">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00688"/>
        </source>
    </evidence>
    <sequence length="234" mass="26584" checksum="829CB890D420B56F" modified="2005-12-06" version="1">MRLVQLSRHSIAFPSPEGALREPNGLLALGGDLSPARLLMAYQRGIFPWFSPGDPILWWSPDPRAVLWPESLHISRSMKRFHKRSPYRVTMNYAFGQVIEGCASDREEGTWITRGVVEAYHRLHELGHAHSIEVWREDELVGGMYGVAQGTLFCGESMFSRMENASKTALLVLCEEFIGHGGKLIDCQVLNDHTASLGACEIPRRDYLNYLNQMRLGRLPNNFWVPRCLFSPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E07</accession>
    <name>Q32E07_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB</name>
        <name evidence="6" type="ordered locus">SDY_2373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000537418.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403939.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E07"/>
    <dbReference type="SMR" id="Q32E07"/>
    <dbReference type="STRING" id="300267.SDY_2373"/>
    <dbReference type="EnsemblBacteria" id="ABB62448">
        <property type="protein sequence ID" value="ABB62448"/>
        <property type="gene ID" value="SDY_2373"/>
    </dbReference>
    <dbReference type="GeneID" id="66670838"/>
    <dbReference type="KEGG" id="sdy:SDY_2373"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2867"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_6"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="321" mass="34623" checksum="8E5AF86FB195CC82" modified="2005-12-06" version="1">MGTTKHSKLLILGSGPAGYTAAVYAARANLQPVLITGMEKGGQLTTTTEVENWPGDPNDLTGPLLMERMHEHATKFETEIIFDHINKVDLQNRPFRLNGDNGEYTCDALIIATGASARYLGLPSEEAFKGRGVSACATCDGFFYRNQKVAVIGGGNTAVEEALYLSNIASEVHLIHRRDGFRAEKILIKRLMDKVENGNIILHTNRTLEEVTGDQMGVTGVRLRDTQNSDNIESLDVAGLFVAIGHSPNTAIFEGQLELENGYIKVQSGIHGNATQTSIPGVFAAGDVMDHIYRQAITSAGTGCMAALDAERYLDGLADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E10</accession>
    <name>Q32E10_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Outer-membrane lipoprotein carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">lolA</name>
        <name evidence="10" type="ordered locus">SDY_2370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the LolA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403936.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E10"/>
    <dbReference type="STRING" id="300267.SDY_2370"/>
    <dbReference type="EnsemblBacteria" id="ABB62445">
        <property type="protein sequence ID" value="ABB62445"/>
        <property type="gene ID" value="SDY_2370"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2370"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2863"/>
    <dbReference type="HOGENOM" id="CLU_087560_1_1_6"/>
    <dbReference type="OMA" id="YDPFVEQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044874">
        <property type="term" value="P:lipoprotein localization to outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00240">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018323">
        <property type="entry name" value="OM_lipoprot_carrier_LolA_Pbac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35869">
        <property type="entry name" value="PTHR35869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00547">
        <property type="entry name" value="lolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 9" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019127" description="Outer-membrane lipoprotein carrier protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="204" mass="22628" checksum="749403123FF719BD" modified="2005-12-06" version="1" precursor="true">MMKKIAITCALLSSLVASSVWADAASDLKSRLDKVSSFHASFTQKVTDGSGAAVQEGQGDLWVKRPNLFNWHMTQPDESILVSDGKTLWFYNPFVEQATATWLKDATGNTPFMLIARNQSSDWQQYNIKQNGDDFVLTPKASNGNLKQFTINVGRDGTIHQFSAVEQDDQRSSYQLKSQQNGAVDAAKFTFTPPQGVTVDDQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E15</accession>
    <name>Q32E15_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isochorismatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycaC</name>
        <name evidence="2" type="ordered locus">SDY_2364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E15"/>
    <dbReference type="STRING" id="300267.SDY_2364"/>
    <dbReference type="EnsemblBacteria" id="ABB62440">
        <property type="protein sequence ID" value="ABB62440"/>
        <property type="gene ID" value="SDY_2364"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2364"/>
    <dbReference type="HOGENOM" id="CLU_066901_1_2_6"/>
    <dbReference type="OMA" id="SNDRMRD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="151" mass="16373" checksum="5AB9876898E14151" modified="2005-12-06" version="1">MTKPYVRLDKNDAAVLLVDHQAGLLSLVRDIEPDKFKNNVLALGDLAKYFNLPTILTTSFETGPNGPLVPELKAQFPDAPYIARPGNINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E28</accession>
    <name>Q32E28_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS2 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_2350</name>
        <name evidence="5" type="ordered locus">SDY_2589</name>
        <name evidence="6" type="ordered locus">SDY_2774</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403918.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404141.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404308.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62427">
        <property type="protein sequence ID" value="ABB62427"/>
        <property type="gene ID" value="SDY_2350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62650">
        <property type="protein sequence ID" value="ABB62650"/>
        <property type="gene ID" value="SDY_2589"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62817">
        <property type="protein sequence ID" value="ABB62817"/>
        <property type="gene ID" value="SDY_2774"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2350"/>
    <dbReference type="KEGG" id="sdy:SDY_2589"/>
    <dbReference type="KEGG" id="sdy:SDY_2774"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2834"/>
    <dbReference type="HOGENOM" id="CLU_027402_25_0_6"/>
    <dbReference type="OMA" id="MVAECEQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="136" mass="15159" checksum="8EA2A0FAC917B3DF" modified="2005-12-06" version="1">MIVLILVFRLVIGEQIIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQIKELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E60</accession>
    <name>Q32E60_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1778</name>
        <name evidence="4" type="ordered locus">SDY_2318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403384.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403886.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61893">
        <property type="protein sequence ID" value="ABB61893"/>
        <property type="gene ID" value="SDY_1778"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62395">
        <property type="protein sequence ID" value="ABB62395"/>
        <property type="gene ID" value="SDY_2318"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1778"/>
    <dbReference type="KEGG" id="sdy:SDY_2318"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2142"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15326" checksum="E31A354E89E0996B" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVTKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E93</accession>
    <name>Q32E93_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403853.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E93"/>
    <dbReference type="STRING" id="300267.SDY_2285"/>
    <dbReference type="EnsemblBacteria" id="ABB62362">
        <property type="protein sequence ID" value="ABB62362"/>
        <property type="gene ID" value="SDY_2285"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2285"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2761"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15394" checksum="120534E58300736A" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQWIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EB8</accession>
    <name>Q32EB8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Antitoxin ParD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000124651.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403828.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EB8"/>
    <dbReference type="STRING" id="300267.SDY_2257"/>
    <dbReference type="EnsemblBacteria" id="ABB62337">
        <property type="protein sequence ID" value="ABB62337"/>
        <property type="gene ID" value="SDY_2257"/>
    </dbReference>
    <dbReference type="GeneID" id="60900899"/>
    <dbReference type="KEGG" id="sdy:SDY_2257"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2726"/>
    <dbReference type="HOGENOM" id="CLU_144805_2_2_6"/>
    <dbReference type="OMA" id="VSAGRYK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022789">
        <property type="entry name" value="ParD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038296">
        <property type="entry name" value="ParD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36582">
        <property type="entry name" value="PTHR36582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03693">
        <property type="entry name" value="ParD_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02606">
        <property type="entry name" value="antidote_CC2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9554" checksum="ECB8221ADF3A4C2B" modified="2005-12-06" version="1">MARTMTVDLGDELREFIESLIESGDYRTQSEVIRESLRLLREKQAESRLQALRDMLAEGLSSGEAQPWEKDAFLRKVKAGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EC0</accession>
    <name>Q32EC0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EC0"/>
    <dbReference type="EnsemblBacteria" id="ABB62335">
        <property type="protein sequence ID" value="ABB62335"/>
        <property type="gene ID" value="SDY_2255"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2255"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8578" checksum="46499C97BFF35D00" modified="2005-12-06" version="1">MITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLHTRIKRLARKTICFSRSVEIHEKVIRTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ER4</accession>
    <name>Q32ER4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ER4"/>
    <dbReference type="EnsemblBacteria" id="ABB62191">
        <property type="protein sequence ID" value="ABB62191"/>
        <property type="gene ID" value="SDY_2100"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2100"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="FKLWIHY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="145" mass="16823" checksum="A4AE12905DC438C0" modified="2005-12-06" version="1">MPKRITSSPVAHADVALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EU4</accession>
    <name>Q32EU4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403652.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EU4"/>
    <dbReference type="STRING" id="300267.SDY_2066"/>
    <dbReference type="EnsemblBacteria" id="ABB62161">
        <property type="protein sequence ID" value="ABB62161"/>
        <property type="gene ID" value="SDY_2066"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2066"/>
    <dbReference type="HOGENOM" id="CLU_163229_0_0_6"/>
    <dbReference type="OMA" id="CXPCYSK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="124" mass="14110" checksum="ED1D1396D3A681E4" modified="2005-12-06" version="1">MSSRVANLTVIVSSKRRRVSVARFSCGKTAQLSKKQTGYYSPEIFPSTGKDCNPQPANCLKDQYVLRHCCVDDRSGKMGYSVKFLVLTRMDTETASLFHCKPCYSKMTFTIYHPLTHSFFTSCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EY8</accession>
    <name>Q32EY8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">phoP</name>
        <name evidence="5" type="ordered locus">SDY_2022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001265481.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403608.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EY8"/>
    <dbReference type="SMR" id="Q32EY8"/>
    <dbReference type="STRING" id="300267.SDY_2022"/>
    <dbReference type="EnsemblBacteria" id="ABB62117">
        <property type="protein sequence ID" value="ABB62117"/>
        <property type="gene ID" value="SDY_2022"/>
    </dbReference>
    <dbReference type="GeneID" id="67414323"/>
    <dbReference type="KEGG" id="sdy:SDY_2022"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2435"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_6"/>
    <dbReference type="OMA" id="FIINVRG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="223" mass="25535" checksum="8BFF22E04F8846EC" modified="2005-12-06" version="1">MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EZ0</accession>
    <name>HFLD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">High frequency lysogenization protein HflD homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hflD</name>
        <name type="ordered locus">SDY_2020</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HflD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001297479.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403606.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EZ0"/>
    <dbReference type="SMR" id="Q32EZ0"/>
    <dbReference type="STRING" id="300267.SDY_2020"/>
    <dbReference type="EnsemblBacteria" id="ABB62115">
        <property type="protein sequence ID" value="ABB62115"/>
        <property type="gene ID" value="SDY_2020"/>
    </dbReference>
    <dbReference type="GeneID" id="67414325"/>
    <dbReference type="KEGG" id="sdy:SDY_2020"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2433"/>
    <dbReference type="HOGENOM" id="CLU_098920_0_0_6"/>
    <dbReference type="OMA" id="RYIISLM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3890.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00695">
        <property type="entry name" value="HflD_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007451">
        <property type="entry name" value="HflD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035932">
        <property type="entry name" value="HflD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38100">
        <property type="entry name" value="PTHR38100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04356">
        <property type="entry name" value="DUF489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101322">
        <property type="entry name" value="SSF101322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000045447" description="High frequency lysogenization protein HflD homolog">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00695"/>
        </source>
    </evidence>
    <sequence length="213" mass="22948" checksum="E26EF9698C3CEE42" modified="2005-12-06" version="1">MAKNYYDITLALAGICQSARLVQQLAHQGHCDADALHVSLNSIIDMNPSSTLAVFGGSEANLRVGLETLLGVLNASSRQGLNAELTRYTLSLMVLERKLSSAKGALDTLGNRINGLQRQLEHFDLQSETLMSAMAAIYVDVISPLGPRIQVTGSPAVLQSPQVQAKVRATLLAGIRAAVLWHQVGGGRLQLMFSRNRLTTQAKQILAHLTPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F16</accession>
    <name>Q32F16_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F16"/>
    <dbReference type="STRING" id="300267.SDY_1990"/>
    <dbReference type="EnsemblBacteria" id="ABB62089">
        <property type="protein sequence ID" value="ABB62089"/>
        <property type="gene ID" value="SDY_1990"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1990"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="CHFRTRR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="64"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="263" mass="30784" checksum="BBFED791AED953AB" modified="2005-12-06" version="1">MCHFRTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSVFMVDEWRRLVYCAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F43</accession>
    <name>Q32F43_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F43"/>
    <dbReference type="STRING" id="300267.SDY_1961"/>
    <dbReference type="EnsemblBacteria" id="ABB62062">
        <property type="protein sequence ID" value="ABB62062"/>
        <property type="gene ID" value="SDY_1961"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1961"/>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_6"/>
    <dbReference type="OMA" id="FPISFNI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="230" mass="26389" checksum="874E67951296615B" modified="2005-12-06" version="1">MLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVDYRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F70</accession>
    <name>Q32F70_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403526.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F70"/>
    <dbReference type="EnsemblBacteria" id="ABB62035">
        <property type="protein sequence ID" value="ABB62035"/>
        <property type="gene ID" value="SDY_1929"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1929"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2325"/>
    <dbReference type="HOGENOM" id="CLU_198378_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="77" mass="8866" checksum="F6B0CA53B36F490F" modified="2005-12-06" version="1">MNYVDRKVISLDASVLFDMPSPTMRILNELHSKGYNVDAAVAEFNAFKHLTEEMRRKLLDISRTSEKSSRFGFNVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FF8</accession>
    <name>Q32FF8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-dependent 7alpha-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hdhA</name>
        <name evidence="1" type="ordered locus">SDY_1838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000483353.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403438.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FF8"/>
    <dbReference type="SMR" id="Q32FF8"/>
    <dbReference type="STRING" id="300267.SDY_1838"/>
    <dbReference type="EnsemblBacteria" id="ABB61947">
        <property type="protein sequence ID" value="ABB61947"/>
        <property type="gene ID" value="SDY_1838"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1838"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2216"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_6"/>
    <dbReference type="OMA" id="VYLCCKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="255" mass="26779" checksum="66CF70E85BD67B6D" modified="2005-12-06" version="1">MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANHVVDEIQQLGGQAFACRCDITSEQELSALADFAISKLGKVDILVNNAGGGGPKPFDMPMADFRRAYELNVFSFFHLSQLVAPEMEKNGGGVILTITSMAAENKNINMTSYASSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSVITPEIEQKMLQHTPIRRLGQPQDIANAALFLCSPAASWVSGQILTVSGGGVQELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FM0</accession>
    <name>Q32FM0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001102901.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403376.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FM0"/>
    <dbReference type="EnsemblBacteria" id="ABB61885">
        <property type="protein sequence ID" value="ABB61885"/>
        <property type="gene ID" value="SDY_1770"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1770"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2134"/>
    <dbReference type="HOGENOM" id="CLU_149921_0_0_6"/>
    <dbReference type="OMA" id="ELYFALM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="137" mass="16696" checksum="E88EF3DED9B65F8D" modified="2005-12-06" version="1">MNVRNVKFDNLSFYEEKIRWRMRRQISNAEAIFYENQEEHIRRFLGRYTCRKPVLVYWESEQRWTSVNGLEVMSMFDEHCHHIYLDDIKKKIQTELPENKTLDFKRQLQFIILGDDKIRIWGPEGKLYFALMGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FW4</accession>
    <name>Q32FW4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000012439.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403282.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FW4"/>
    <dbReference type="STRING" id="300267.SDY_1670"/>
    <dbReference type="EnsemblBacteria" id="ABB61791">
        <property type="protein sequence ID" value="ABB61791"/>
        <property type="gene ID" value="SDY_1670"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1670"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2016"/>
    <dbReference type="HOGENOM" id="CLU_046814_0_0_6"/>
    <dbReference type="OMA" id="SAYKNDM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="421" mass="47028" checksum="121683F8C943EF0F" modified="2005-12-06" version="1">MSGFAQGLLAGFSTVDQAMTRRKELGLREAQLAQQQKNNERDFEFAQSQFEHNKDVDQRNFDYRAKVDDRNYALQEREFNANQNYRNASLGMEQQRLRMQKYNQRRLEYNDMLARDQPVMAALGKAVDAGDRDAAMRLYGQLSEGNPLRLMANDGYVAKAGQAVNNLQKIFDDKPDRAIASLNTPENLDVLSGVFGPELQQRIGMPDSTGKKTIKEARIGSIVPAQQEGYILIGLDLTYSDGSTAHKPVTEYGSAHPDDQTVLAVPVDKAVELVRDRSKFAEISKNFGYFTPKQQGLSADQLQKGASQVAIKVAQDGGDAQGAVTQYYASMGLPQYQQQIQQQKIQQGITSWAGDDPDKQAFAREVASRQPEMLEPQNQKLLEHGYANFLRIQKARGEQARDDSAASASEFIRGLKQNYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FY8</accession>
    <name>Q32FY8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FY8"/>
    <dbReference type="STRING" id="300267.SDY_1643"/>
    <dbReference type="EnsemblBacteria" id="ABB61767">
        <property type="protein sequence ID" value="ABB61767"/>
        <property type="gene ID" value="SDY_1643"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1643"/>
    <dbReference type="HOGENOM" id="CLU_1293586_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="213" mass="23720" checksum="6BAFD808AA040E6B" modified="2005-12-06" version="1">MSVKLRLPQEARRQTGDNRQTITDVPDTEVPVPVPVPVDKPSTHQQARGAKIEDFGEEIKGAAKHRYAQLAEAMGKTLEDGEYATQPLSKLFPKPDYARLEKEGVDSDTLAMMALYRSEIPTRTSRNIQKWISIVKSGREATAGMLEGKIPAAKLADMMDSKPGLRSMSDTWKLLRTLSASQIDKASGYRVRSGVYSFVGGKRYDPPQMMYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G15</accession>
    <name>Q32G15_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gadB</name>
        <name evidence="10" type="ordered locus">SDY_1615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H(+) + L-glutamate = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000358851.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403231.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G15"/>
    <dbReference type="STRING" id="300267.SDY_1615"/>
    <dbReference type="EnsemblBacteria" id="ABB61740">
        <property type="protein sequence ID" value="ABB61740"/>
        <property type="gene ID" value="SDY_1615"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1615"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1943"/>
    <dbReference type="HOGENOM" id="CLU_019582_0_0_6"/>
    <dbReference type="OMA" id="TMAPHSE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="PTHR43321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="466" mass="52684" checksum="C9C8F54CB941CFC3" modified="2005-12-06" version="1">MDKKQVTDLRSELLDSRFGAKSISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDDNVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEITKLGPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDLVVMRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GH9</accession>
    <name>Q32GH9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rem</name>
        <name evidence="1" type="ordered locus">SDY_1433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000980987.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403067.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GH9"/>
    <dbReference type="EnsemblBacteria" id="ABB61576">
        <property type="protein sequence ID" value="ABB61576"/>
        <property type="gene ID" value="SDY_1433"/>
    </dbReference>
    <dbReference type="GeneID" id="58392144"/>
    <dbReference type="KEGG" id="sdy:SDY_1433"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1708"/>
    <dbReference type="HOGENOM" id="CLU_2507391_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016418">
        <property type="entry name" value="UCP004509_Rem"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004509">
        <property type="entry name" value="UCP004509_Rem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9233" checksum="8442BA4F5AB8CF3F" modified="2005-12-06" version="1">MMNIEELRKIFCEDGLYAVCVENGNIVSHYRIVCLQKNGAALINFVDARVTDGFILRDGEFVTSLQALKEIGIKAGFSAFSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GL0</accession>
    <name>Q32GL0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HTH-type transcriptional regulatory protein TyrR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">tyrR</name>
        <name evidence="14" type="ordered locus">SDY_1401</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295587.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403036.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GL0"/>
    <dbReference type="STRING" id="300267.SDY_1401"/>
    <dbReference type="EnsemblBacteria" id="ABB61545">
        <property type="protein sequence ID" value="ABB61545"/>
        <property type="gene ID" value="SDY_1401"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1401"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1662"/>
    <dbReference type="HOGENOM" id="CLU_000445_8_2_6"/>
    <dbReference type="OMA" id="CQNRIGI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030828">
        <property type="entry name" value="HTH_TypR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18024">
        <property type="entry name" value="HTH_50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04381">
        <property type="entry name" value="HTH_TypR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ACT" evidence="13">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="11">
        <location>
            <begin position="206"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB61545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="513" mass="57686" checksum="B580A31B03A274E2" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GT8</accession>
    <name>Q32GT8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yciD</name>
        <name evidence="2" type="ordered locus">SDY_1320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000737234.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402958.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GT8"/>
    <dbReference type="STRING" id="300267.SDY_1320"/>
    <dbReference type="EnsemblBacteria" id="ABB61467">
        <property type="protein sequence ID" value="ABB61467"/>
        <property type="gene ID" value="SDY_1320"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1320"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1567"/>
    <dbReference type="HOGENOM" id="CLU_042505_1_1_6"/>
    <dbReference type="OMA" id="DYMLTDN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005618">
        <property type="entry name" value="OMPW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36920">
        <property type="entry name" value="PTHR36920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03922">
        <property type="entry name" value="OmpW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220987" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="212" mass="22952" checksum="E17EDA1CDBF11220" modified="2005-12-06" version="1">MKKLTVAALAVTTLLSGSAFAHEAGEFFMRAGSATVRPTEGAGGTLGSLGGFSVTNNTQLGLTFTYMATDNIGVELLAATPFRHKIGTRVPGDIATVHHLPPTLMAQWYFGDASSKFRPYVGAGINYTTFFDNGFNDHGKEAGLSDLSLKDSWGAAGQVGVDYLINRDWLVNMSVWYMDIDTTANYKLGGAQQHDSVRLDPWVFMFSAGYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GW7</accession>
    <name>Q32GW7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402929.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GW7"/>
    <dbReference type="EnsemblBacteria" id="ABB61438">
        <property type="protein sequence ID" value="ABB61438"/>
        <property type="gene ID" value="SDY_1291"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1291"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1530"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15368" checksum="E1B4F54EC9E4D92F" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFCPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GX6</accession>
    <name>Q32GX6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate reductase 1, delta subunit, assembly function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">narJ</name>
        <name evidence="2" type="ordered locus">SDY_1281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000571689.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402920.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GX6"/>
    <dbReference type="STRING" id="300267.SDY_1281"/>
    <dbReference type="EnsemblBacteria" id="ABB61429">
        <property type="protein sequence ID" value="ABB61429"/>
        <property type="gene ID" value="SDY_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1281"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1520"/>
    <dbReference type="HOGENOM" id="CLU_084469_0_0_6"/>
    <dbReference type="OMA" id="CELFDRG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="236" mass="26479" checksum="1747EE233627AC09" modified="2005-12-06" version="1">MIELVIVSRLLEYPDAALWQHQQEMFEAIAASKNLPKEDAHVLGIFLRDLTAMDPLDAQAQYSELFDRGRATSLLLFEHVHGESRDRGQAMVDLLAQYEQHGLQLNSRELPDHLPLYLEYLSQLPQSEAVEGLKDIAPILALLSARLQQRESRYAVLFDLLLKLANTAIDSDKVAEKIADEARDDTPQALDSVWEEEQVKFFADKGCGDSAITAHQRRFAGAVAPQYLNITTGGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H63</accession>
    <name>Q32H63_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402833.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H63"/>
    <dbReference type="EnsemblBacteria" id="ABB61342">
        <property type="protein sequence ID" value="ABB61342"/>
        <property type="gene ID" value="SDY_1187"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1187"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1404"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="KKHHQMA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27442" checksum="5F5DD9D28D318BC9" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQSGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFRKKHHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H83</accession>
    <name>Q32H83_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0312</name>
        <name evidence="4" type="ordered locus">SDY_1165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402020.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402813.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0312"/>
    <dbReference type="EnsemblBacteria" id="ABB60531">
        <property type="protein sequence ID" value="ABB60531"/>
        <property type="gene ID" value="SDY_0312"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61322">
        <property type="protein sequence ID" value="ABB61322"/>
        <property type="gene ID" value="SDY_1165"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0312"/>
    <dbReference type="KEGG" id="sdy:SDY_1165"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1372"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15338" checksum="886534E197513276" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVESHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HB8</accession>
    <name>Q32HB8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000944256.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402778.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HB8"/>
    <dbReference type="SMR" id="Q32HB8"/>
    <dbReference type="STRING" id="300267.SDY_1130"/>
    <dbReference type="EnsemblBacteria" id="ABB61287">
        <property type="protein sequence ID" value="ABB61287"/>
        <property type="gene ID" value="SDY_1130"/>
    </dbReference>
    <dbReference type="GeneID" id="66674266"/>
    <dbReference type="KEGG" id="sdy:SDY_1130"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1332"/>
    <dbReference type="HOGENOM" id="CLU_047806_8_2_6"/>
    <dbReference type="OMA" id="SPYYVAH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="3">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="220" mass="25133" checksum="A1863A22C8C57A6F" modified="2005-12-06" version="1">MLRIIDTETCGLQGGIVEIASVDVIDGKIVNPMSHLVRPDRPISPQAMAIHRITEAMVADKPWIEDVIPHYYGSEWYVAHNASFDRRVLPEMPGEWICTMKLARRLWPGIKYSNMALYKTRKLNVQTPPGLHHHRALYDCYITAALLIDIMNTSGWTAEQMADITGRPSLMTTFTFGKYRGKAVSDVAERDPGYLRWLFNNLDSMSPELRLTLKHYLENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HE2</accession>
    <name>Q32HE2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yecF</name>
        <name evidence="1" type="ordered locus">SDY_1103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000106474.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402754.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HE2"/>
    <dbReference type="SMR" id="Q32HE2"/>
    <dbReference type="STRING" id="300267.SDY_1103"/>
    <dbReference type="EnsemblBacteria" id="ABB61263">
        <property type="protein sequence ID" value="ABB61263"/>
        <property type="gene ID" value="SDY_1103"/>
    </dbReference>
    <dbReference type="GeneID" id="67415816"/>
    <dbReference type="KEGG" id="sdy:SDY_1103"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1298"/>
    <dbReference type="HOGENOM" id="CLU_200496_0_0_6"/>
    <dbReference type="OMA" id="MTLMLKS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019705">
        <property type="entry name" value="DUF2594"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10769">
        <property type="entry name" value="DUF2594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="74" mass="8239" checksum="4D20DA9A0B4DD888" modified="2005-12-06" version="1">MSTPDFSTAENNQELANEVSCLKAMLTLMLQAMGQADAGRVMLKMEKQLALIEDETQAAVFSKTVKQIKQAYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HH4</accession>
    <name>Q32HH4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tail fiber assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402722.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HH4"/>
    <dbReference type="EnsemblBacteria" id="ABB61231">
        <property type="protein sequence ID" value="ABB61231"/>
        <property type="gene ID" value="SDY_1066"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1066"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1254"/>
    <dbReference type="HOGENOM" id="CLU_094206_1_0_6"/>
    <dbReference type="OMA" id="TYNAINW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003458">
        <property type="entry name" value="Phage_T4_Gp38_tail_assem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02413">
        <property type="entry name" value="Caudo_TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="162" mass="18573" checksum="BBF6028781D034BD" modified="2005-12-06" version="1">MTKRYSVTRLFSEDDKNWYEELKNFASDTIKIAYTGDGRVVWVGKDVTGIEPRNASVIEVPDITANRRITAPGYWFYRNDEFVFDYRLKAEDERNALLAQVSAQTGEWEEDLLLGLISDEDKEKLKACRIYAKSLQAMDFSTITDKSSYNAIEWSVSPEGSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HK5</accession>
    <name>MSRP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-methionine-sulfoxide reductase catalytic subunit MsrP</fullName>
            <ecNumber evidence="1">1.8.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msrP</name>
        <name type="ordered locus">SDY_1035</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:51292"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:51296"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="1">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
        <text evidence="1">Is attached to the inner membrane when interacting with the MsrQ subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrP family.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000740056.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402691.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HK5"/>
    <dbReference type="SMR" id="Q32HK5"/>
    <dbReference type="STRING" id="300267.SDY_1035"/>
    <dbReference type="EnsemblBacteria" id="ABB61200">
        <property type="protein sequence ID" value="ABB61200"/>
        <property type="gene ID" value="SDY_1035"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1035"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1209"/>
    <dbReference type="HOGENOM" id="CLU_045520_0_0_6"/>
    <dbReference type="OMA" id="WPYTEGL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016672">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01206">
        <property type="entry name" value="MsrP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022867">
        <property type="entry name" value="MsrP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0500">Molybdenum</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" description="Tat-type signal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_1000066165" description="Protein-methionine-sulfoxide reductase catalytic subunit MsrP" evidence="1">
        <location>
            <begin position="45"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="249"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01206"/>
        </source>
    </evidence>
    <sequence length="334" mass="37367" checksum="174CB0352EFAE0EC" modified="2005-12-06" version="1" precursor="true">MKKNQFLKESDITAESVFFMKRRQVLKALGISAAALSLPHAAHADLLSWFKGNDRPPAPAGKPLEFSKPAAWQNNLPLTPADKVSGYNNFYEFGLDKADPAANAGSLKTDTWTLKISGEVAKPLTLDHDDLTRRFPLEERIYRMRCVEAWSMVVPWIGFPLHKLLALAEPTSNAKYVAFETIYAPEQMPGLQDRFIGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPVRLIVPWKYGFKGIKSIVSIKLTREHPPTTWNLAAPDEYGFYANVNPHVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYADQVASLYRGLDLRENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HP0</accession>
    <name>Q32HP0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Curli production assembly/transport component CsgG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">csgG</name>
        <name evidence="5" type="ordered locus">SDY_0999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the biogenesis of curli organelles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CsgG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001189330.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402656.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HP0"/>
    <dbReference type="STRING" id="300267.SDY_0999"/>
    <dbReference type="EnsemblBacteria" id="ABB61165">
        <property type="protein sequence ID" value="ABB61165"/>
        <property type="gene ID" value="SDY_0999"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0999"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1167"/>
    <dbReference type="HOGENOM" id="CLU_056911_0_0_6"/>
    <dbReference type="OMA" id="NEPAQLC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005534">
        <property type="entry name" value="Curli_assmbl/transp-comp_CsgG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03783">
        <property type="entry name" value="CsgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220843" description="Curli production assembly/transport component CsgG" evidence="4">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="277" mass="30572" checksum="A891C00D5E9DB279" modified="2005-12-06" version="1">MQRLFLLVAVMLLSGCLTAPPKEAARPTLMPRAQSYKDLTHLPTPTGKIFVSVYNIPDETGQFKPYPASNFSTAVPQSATAMLVTALKDSRWFIPLERQGLQNLLNERKIIRTAQENGTVAINNRIPLQSLTAANIMVEGSIIGYESNVKSGGVGARYFGIGADTQYQLDQIAVNLRVVNVSTGEILSSVNTSKTILSYEVQVGVFRFIDYQRLLEGEVGYTSNEPVMLCLMSAIETGGIFLINDGIDRGLWDLQNKAERQNDILVKYRHMSVPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HP2</accession>
    <name>Q32HP2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Curli production assembly/transport component CsgE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">csgE</name>
        <name evidence="5" type="ordered locus">SDY_0997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the biogenesis of curli organelles.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000833289.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402654.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HP2"/>
    <dbReference type="STRING" id="300267.SDY_0997"/>
    <dbReference type="EnsemblBacteria" id="ABB61163">
        <property type="protein sequence ID" value="ABB61163"/>
        <property type="gene ID" value="SDY_0997"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0997"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1165"/>
    <dbReference type="HOGENOM" id="CLU_131424_0_0_6"/>
    <dbReference type="OMA" id="VGHDFYR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018900">
        <property type="entry name" value="Curli_CsgE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10627">
        <property type="entry name" value="CsgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221126" description="Curli production assembly/transport component CsgE" evidence="4">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="129" mass="14821" checksum="A309D4EE54484C33" modified="2005-12-06" version="1">MKRYLRWIVAAEFLFAAGNLHAVEVEVPGLLTDHTVSSIGHDFYRAFSDKWESDYTGNLTINERPSARWGSWITITVNQDVIFQTFLFPLKRDFEKTVVFALIQTEEALNRRQINQALLSTGDLAHGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HW2</accession>
    <name>Q32HW2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ycbF</name>
        <name evidence="9" type="ordered locus">SDY_0917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the periplasmic pilus chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001111480.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402584.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HW2"/>
    <dbReference type="STRING" id="300267.SDY_0917"/>
    <dbReference type="EnsemblBacteria" id="ABB61093">
        <property type="protein sequence ID" value="ABB61093"/>
        <property type="gene ID" value="SDY_0917"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0917"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1063"/>
    <dbReference type="HOGENOM" id="CLU_070768_2_2_6"/>
    <dbReference type="OMA" id="VSWRTIN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036316">
        <property type="entry name" value="Pili_assmbl_chap_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001829">
        <property type="entry name" value="Pili_assmbl_chaperone_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016148">
        <property type="entry name" value="Pili_assmbl_chaperone_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018046">
        <property type="entry name" value="Pili_assmbl_chaperone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016147">
        <property type="entry name" value="Pili_assmbl_chaperone_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02753">
        <property type="entry name" value="PapD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00345">
        <property type="entry name" value="PapD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00969">
        <property type="entry name" value="CHAPERONPILI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="SSF49354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49584">
        <property type="entry name" value="SSF49584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00635">
        <property type="entry name" value="PILI_CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PapD_N" evidence="7">
        <location>
            <begin position="36"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_C" evidence="8">
        <location>
            <begin position="181"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="245" mass="26967" checksum="96081492B618D89D" modified="2005-12-06" version="1">MPARHLYFIMTNTWNRLALLIFSVLSLLVAGELQAGVVVGGTRFIFPADRESISILLTNTSQESWLINSKINRPTRWAGGEASTVPAPLLAAPPLILLKPGTTGTLRLLRTESDILPVDRETLFELSIASVPSGKVENQSVKVAMRSVFKPFWRPEGLPGDPLEAYQQLRWTRNSQGVQLTNPTPYYINLIQVSVNGKALSNVGVVPPKSLRQTSWCQAIAPCHVAWRAINDYGGLSAKKEQNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HZ5</accession>
    <name>Q32HZ5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiol:disulfide interchange protein DsbE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c biogenesis protein CcmG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dsbE</name>
        <name evidence="9" type="ordered locus">SDY_0883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family. DsbE subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000824454.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402551.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HZ5"/>
    <dbReference type="STRING" id="300267.SDY_0883"/>
    <dbReference type="EnsemblBacteria" id="ABB61060">
        <property type="protein sequence ID" value="ABB61060"/>
        <property type="gene ID" value="SDY_0883"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0883"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1018"/>
    <dbReference type="HOGENOM" id="CLU_042529_19_1_6"/>
    <dbReference type="OMA" id="MIGKPFP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03010">
        <property type="entry name" value="TlpA_like_DsbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004799">
        <property type="entry name" value="Periplasmic_diS_OxRdtase_DsbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00385">
        <property type="entry name" value="dsbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="39"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="185" mass="20829" checksum="B809E6A4083C6990" modified="2005-12-06" version="1">MKRKVLLIPLIIFLAIAAALLWQLARNAEGDDPTNLESALIGKSVPKFRLESLDNPGQFYQADVLTQGKPVLLNVWATWCPTCRTEHQYLNQLSAQGIRVVGMNYKDDRQKAISWLKELGNPYALSLFDGDGMLGLDLGVYGAPETFLIDGNGIIRYRHAGDLNPRVWEEEIKPLWEKYSKEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I43</accession>
    <name>Q32I43_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">bioA</name>
        <name evidence="6" type="ordered locus">SDY_0832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000205520.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402503.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I43"/>
    <dbReference type="STRING" id="300267.SDY_0832"/>
    <dbReference type="EnsemblBacteria" id="ABB61014">
        <property type="protein sequence ID" value="ABB61014"/>
        <property type="gene ID" value="SDY_0832"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0832"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.958"/>
    <dbReference type="HOGENOM" id="CLU_016922_4_3_6"/>
    <dbReference type="OMA" id="VAVKMCL"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="308"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="429" mass="47376" checksum="1D80FF736CB54EFF" modified="2005-12-06" version="1">MTTDDLAFDQRHIWHPYTSMTSPLPVYPVASAEGCELILSDGRRLVDGMSSWWAAIHGYNHPQLNAAMKTQIDAMSHVMFGGITHAPAIELCRKLVAMTPQPLECVFLADSGSVAVEVAMKMALQYWQAKGEARQRFLTFRNGYHGDTFGAMSVCDPDNSMHSLWKGYLPENLFAPAPQSRMDGEWDERDMVGFARLMAAHRHEIAAVIIEPIVQGAGGMRMYHPEWLKRIRKMCDREGILLIADEIATGFGRTGKLFACEYAEIAPDILCLGKALTGGTMTLSATLTTREVAETISNGEAGCFMHGPTFMGNPLACAAANASLAILESGDWQHQVAAIEAQLREQLAPARDTEMVADVRVLGAIGVVETTRPVNMAALQKFFVEQGVWIRPFGKLIYLMPPYIIHPQQLQRLTAAVNRAVQDETFFCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IP3</accession>
    <name>Q32IP3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IP3"/>
    <dbReference type="EnsemblBacteria" id="ABB60814">
        <property type="protein sequence ID" value="ABB60814"/>
        <property type="gene ID" value="SDY_0621"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0621"/>
    <dbReference type="HOGENOM" id="CLU_1073235_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="259" mass="28265" checksum="981F90F3C7E6DBED" modified="2005-12-06" version="1">MLIQALYASFRRLSSCGAVDCAQATSPDAIMAMRISFFIANSSNMRQAQNLPRRASEDGEWCDYHKFHVTLILEDVAVTTAPVWDVGVVVVFGEVQFEHRAFGATVLNGVDRIQAVGRLFNSPVFVVVRIRIALLGRRFSIPCVNVGSADGEAWKIPIFQVIHRTEEDRFFAVGVEVRTVIPPDIQATVRGSVGWSHTLQEVSLLTVSFNPGAFEAQIHYVSRPVTKGQRLQPGGAVIKIVDAAIVNFIAGTVELVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IW2</accession>
    <name>Q32IW2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Alkyl hydroperoxide reductase C</fullName>
            <ecNumber evidence="4 9">1.11.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ahpC</name>
        <name evidence="11" type="ordered locus">SDY_0540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:62628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.11.1.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.26" evidence="4 9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000052801.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402234.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IW2"/>
    <dbReference type="STRING" id="300267.SDY_0540"/>
    <dbReference type="PeroxiBase" id="4831">
        <property type="entry name" value="SdyAhpC"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60745">
        <property type="protein sequence ID" value="ABB60745"/>
        <property type="gene ID" value="SDY_0540"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0540"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.640"/>
    <dbReference type="HOGENOM" id="CLU_042529_21_3_6"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102039">
        <property type="term" value="F:alkylhydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03137">
        <property type="entry name" value="AhpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="187" mass="20757" checksum="05AF67D6DE81740D" modified="2005-12-06" version="1">MSLINTKIKPFKNQAFKNGEFIEITEKDTEGRWSVFFFYPADFTFVCPTELGDVADYYEELQKLGVDVYAVSTDTHFTHKAWHSSSEAIAKIKYAMIGDPTGALTRNFDNMREDEGLADRATFVVDPQGIIQAIEVTAEGIGRDASDLLRKIKAAQYVASHPGEVCPAKWKEGEATLAPSLDLVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IX9</accession>
    <name>Q32IX9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferric enterobactin transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fepD</name>
        <name evidence="8" type="ordered locus">SDY_0521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019334.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402217.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IX9"/>
    <dbReference type="STRING" id="300267.SDY_0521"/>
    <dbReference type="EnsemblBacteria" id="ABB60728">
        <property type="protein sequence ID" value="ABB60728"/>
        <property type="gene ID" value="SDY_0521"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0521"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.614"/>
    <dbReference type="HOGENOM" id="CLU_013016_1_0_6"/>
    <dbReference type="OMA" id="VFIWIVR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="334" mass="33871" checksum="B64214F80589A7D7" modified="2005-12-06" version="1">MSGSVAVTRAIAVPGLLLLLIIATALSLLIGAKSLPASIVLEAFSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRVIVPGELRVSVVSAFIGAPVLIFLVRRKTRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J72</accession>
    <name>Q32J72_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J72"/>
    <dbReference type="STRING" id="300267.SDY_0424"/>
    <dbReference type="EnsemblBacteria" id="ABB60635">
        <property type="protein sequence ID" value="ABB60635"/>
        <property type="gene ID" value="SDY_0424"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0424"/>
    <dbReference type="HOGENOM" id="CLU_031871_0_0_6"/>
    <dbReference type="OMA" id="GYWNASM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="275"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="365"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="497" mass="48810" checksum="3BA020B034BD1E05" modified="2005-12-06" version="1">MGVTAAQVSAWPAGTVNIAVSGESSAGNPISITHPVTVDLTPAAITINTIATDDVINAAEKGANLTLSGTTTNVEAGQTVTVTFGGKNYTASVAGDGSWTATVPAADLAALPEGSASAQASVSNINGNSASAVHNYSVDSSAPTIIINTVASDNIVNASEADAGVTVSGSTTAEAGQIVTITLNSPTVQTYQATVQADGSWSINIPAADLEALTDGSHTLTATVNDKAGNPASTTHNLAVDLTVPVLTINTIAGDDIINATEHGQALVISGSSTGGEAGDVVSVTLNSKTYTTTLDASGNWSVGVPAADVTALGSGPQTVTATVTDAAGNSDNETHTVTVNLTAPTIGINTIATDDVINATEKGADLQISGTSNQPAGTTITVTLNGQNYTATTDASGNWSTTVPASAVGALGEASYTVTANVTDSAGNSNSASHNVQVNTALPGVTLNPVASDDIINAAESGVAQTISGQVTGAAAGDTVTVTLGGKTYTATVAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JI9</accession>
    <name>Q32JI9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polymerase/proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yajG</name>
        <name evidence="2" type="ordered locus">SDY_0299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JI9"/>
    <dbReference type="STRING" id="300267.SDY_0299"/>
    <dbReference type="EnsemblBacteria" id="ABB60518">
        <property type="protein sequence ID" value="ABB60518"/>
        <property type="gene ID" value="SDY_0299"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0299"/>
    <dbReference type="HOGENOM" id="CLU_098976_0_0_6"/>
    <dbReference type="OMA" id="NNIYQDQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012640">
        <property type="entry name" value="Membr_lipoprot_lipid_attach_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005619">
        <property type="entry name" value="Uncharacterised_YajG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03923">
        <property type="entry name" value="Lipoprotein_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08139">
        <property type="entry name" value="LPAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="226" mass="24957" checksum="89BDED390207C804" modified="2005-12-06" version="1">MMNLHALPTSPRRWQCYDGGNFYQTRLRVSESPNMFKKILFPLVALFMLAGCAKPPTTIEVSPTITLPQQDPSLMGVTVSINGADQRNDQALAKVTRDNQIVTLTASRDLRFLLQEVLEKQMTARGYMVGPNGPVNLQIIVSQLYADVSLGNVRYNIATKADIAIIATAQNGNKMTKNYRASYNVEGAFQASNKNIADAVNSVLTDTIADMSQDTSIHEFIKQNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JR9</accession>
    <name>Q32JR9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yaeO</name>
        <name evidence="1" type="ordered locus">SDY_0207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000062312.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401927.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JR9"/>
    <dbReference type="SMR" id="Q32JR9"/>
    <dbReference type="STRING" id="300267.SDY_0207"/>
    <dbReference type="EnsemblBacteria" id="ABB60438">
        <property type="protein sequence ID" value="ABB60438"/>
        <property type="gene ID" value="SDY_0207"/>
    </dbReference>
    <dbReference type="GeneID" id="66671523"/>
    <dbReference type="KEGG" id="sdy:SDY_0207"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.241"/>
    <dbReference type="HOGENOM" id="CLU_176324_0_1_6"/>
    <dbReference type="OMA" id="TEYQPIN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009778">
        <property type="entry name" value="ROF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038626">
        <property type="entry name" value="Rof-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07073">
        <property type="entry name" value="ROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="SSF101744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9698" checksum="2C1AC8C9D9E1F156" modified="2005-12-06" version="1">MSMNDTYQPINCDDYDNLELACQHHLMLTLELKDGEKLQAKASDLVSRKNVEYLVVEAAGETRELRLDKITSFSHPEIGTVVVSES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JT1</accession>
    <name>SKP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Chaperone protein Skp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">skp</name>
        <name type="ordered locus">SDY_0194</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000758956.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401915.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JT1"/>
    <dbReference type="SMR" id="Q32JT1"/>
    <dbReference type="STRING" id="300267.SDY_0194"/>
    <dbReference type="EnsemblBacteria" id="ABB60426">
        <property type="protein sequence ID" value="ABB60426"/>
        <property type="gene ID" value="SDY_0194"/>
    </dbReference>
    <dbReference type="GeneID" id="67416254"/>
    <dbReference type="KEGG" id="sdy:SDY_0194"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.225"/>
    <dbReference type="HOGENOM" id="CLU_101388_2_0_6"/>
    <dbReference type="OMA" id="EKEQYDM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002094">
        <property type="entry name" value="OMP26_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000227894" description="Chaperone protein Skp">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lipopolysaccharide binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="161" mass="17688" checksum="2A966BBD83F3E675" modified="2005-12-06" version="1" precursor="true">MKKWLLAAGLGLALATSAQAADKIAIVNMGSLFQQVAQKTGVSNTLENEFKGRASELQRMETDLQAKMKKLQSMKAGSDRTKLEKDVMAQRQTFAQKAQAFEQDRARRSNEERGKLVTRIQTAVKSVANSQDIDLVVDANAVAYNSSDVKDITADVLKQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K37</accession>
    <name>Q32K37_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yabO</name>
        <name evidence="5" type="ordered locus">SDY_0082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000525176.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401809.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K37"/>
    <dbReference type="SMR" id="Q32K37"/>
    <dbReference type="STRING" id="300267.SDY_0082"/>
    <dbReference type="EnsemblBacteria" id="ABB60320">
        <property type="protein sequence ID" value="ABB60320"/>
        <property type="gene ID" value="SDY_0082"/>
    </dbReference>
    <dbReference type="GeneID" id="66671653"/>
    <dbReference type="KEGG" id="sdy:SDY_0082"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.92"/>
    <dbReference type="HOGENOM" id="CLU_016902_11_1_6"/>
    <dbReference type="OMA" id="HVSQSRM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="24861" checksum="2ADCE6D779D8C4AB" modified="2005-12-06" version="1">MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K90</accession>
    <name>SPEE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="1">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Spermidine synthase</fullName>
            <shortName evidence="1">SPDS</shortName>
            <shortName evidence="1">SPDSY</shortName>
            <ecNumber evidence="1">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">speE</name>
        <name type="ordered locus">SDY_0028</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000818403.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401756.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K90"/>
    <dbReference type="SMR" id="Q32K90"/>
    <dbReference type="STRING" id="300267.SDY_0028"/>
    <dbReference type="EnsemblBacteria" id="ABB60268">
        <property type="protein sequence ID" value="ABB60268"/>
        <property type="gene ID" value="SDY_0028"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0028"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.30"/>
    <dbReference type="HOGENOM" id="CLU_048199_0_0_6"/>
    <dbReference type="OMA" id="LWPGQSF"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="PTHR11558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000012018" description="Polyamine aminopropyltransferase">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="1">
        <location>
            <begin position="9"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="158"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <sequence length="288" mass="32333" checksum="95EE132828B19B1E" modified="2005-12-06" version="1">MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLPNHNAGSYDDLRFKLVIDDGVNFVNQTSQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSTEIIQARFLASGLKCRYYNPAVHTAAFALPQYLQDALAPQPS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KB0</accession>
    <name>TAL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transaldolase</fullName>
            <ecNumber evidence="2">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tal</name>
        <name type="ordered locus">SDY_0008</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000130187.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401736.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KB0"/>
    <dbReference type="SMR" id="Q32KB0"/>
    <dbReference type="STRING" id="300267.SDY_0008"/>
    <dbReference type="EnsemblBacteria" id="ABB60248">
        <property type="protein sequence ID" value="ABB60248"/>
        <property type="gene ID" value="SDY_0008"/>
    </dbReference>
    <dbReference type="GeneID" id="67416088"/>
    <dbReference type="KEGG" id="sdy:SDY_0008"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.8"/>
    <dbReference type="HOGENOM" id="CLU_047470_0_1_6"/>
    <dbReference type="OMA" id="KFGYKTL"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="PTHR10683:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0570">Pentose shunt</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000230972" description="Transaldolase">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00492"/>
        </source>
    </evidence>
    <sequence length="317" mass="35205" checksum="2DF03D741E4FCF31" modified="2005-12-06" version="1">MTDKLTSLRQYTTVVADTGDIAAMKLYQPQDATTNPSLILNAAQIPEYRKLIDDAVAWAKQQSNDRAQQIVDATDKLAVNIGLEILKLVPGRISTEVDARLSYDTEASIAKAKRLIKLYNDAGISNDRILIKLASTWQGIRAAEQLEKEGINCNLTLLFSFAQARACAEAGVFLISPFVGRILDWYKANTDKKEYAPAEDPGVVSVSEIYQYYKEHGYETVVMGASFRNIGEILELAGCDRLTIAPALLKELAESEGAIERKLSYTGEVKARPARITESEFLWQHNQDPMAVDKLAEGIRKFAVDQEKLEKMIGDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q326M7</accession>
    <name>Q326M7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406219.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326M7"/>
    <dbReference type="EnsemblBacteria" id="ABB64731">
        <property type="protein sequence ID" value="ABB64731"/>
        <property type="gene ID" value="SDY_P218"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P218"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5772"/>
    <dbReference type="HOGENOM" id="CLU_2652466_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="76" mass="8540" checksum="C148EFD9C3D458CE" modified="2005-12-06" version="1">MNTTFPLLFFSTAAFWLSLKSLARRDLELHDEIADLDVMIAAIVDELAPELIKRNAIGYESASQLLISQVADFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Q4</accession>
    <name>Q326Q4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Spa24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">spa24</name>
        <name evidence="9" type="ordered locus">SDY_P191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Sd197</strain>
            <plasmid evidence="10">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000947538.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406192.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Q4"/>
    <dbReference type="EnsemblBacteria" id="ABB64704">
        <property type="protein sequence ID" value="ABB64704"/>
        <property type="gene ID" value="SDY_P191"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P191"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5742"/>
    <dbReference type="HOGENOM" id="CLU_042028_2_0_6"/>
    <dbReference type="OMA" id="SIVLVMM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005773">
        <property type="entry name" value="YopR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01102">
        <property type="entry name" value="yscR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01060">
        <property type="entry name" value="FLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="216" mass="24182" checksum="CBAE0624CAEF7EF0" modified="2005-12-06" version="1">MLSDMSLIATLSFFTLLPFLVAAGTCYIKFSIVFVMVRNALGLQQVPSNMTLNGIALIMALFVMKPIIEAGYENYLNGPQKFDTISDIVRFSDSGLIEYKQYLKKHTDLELARFFQRSEEENADLKSAENNDYSLFSLLPAYALSEIKDAFKIGFYLYLPFIVVDLVISSILLALGMMMMSPITISVPIKLVLFVALDGWGILSKALIEQYINVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q326X3</accession>
    <name>Q326X3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OriT nicking and unwinding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_P122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Sd197</strain>
            <plasmid evidence="6">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406123.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326X3"/>
    <dbReference type="EnsemblBacteria" id="ABB64635">
        <property type="protein sequence ID" value="ABB64635"/>
        <property type="gene ID" value="SDY_P122"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P122"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5677"/>
    <dbReference type="HOGENOM" id="CLU_001748_2_0_6"/>
    <dbReference type="OMA" id="STWETHR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014059">
        <property type="entry name" value="Conjug_relaxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014129">
        <property type="entry name" value="Conjug_relaxase_TraI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009767">
        <property type="entry name" value="DNA_helicase_TraI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040668">
        <property type="entry name" value="TraI_2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040987">
        <property type="entry name" value="TraI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18272">
        <property type="entry name" value="ssDNA_TraI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07057">
        <property type="entry name" value="TraI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18340">
        <property type="entry name" value="TraI_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02686">
        <property type="entry name" value="relax_trwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02760">
        <property type="entry name" value="TraI_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ssDNA_TraI_N" evidence="3">
        <location>
            <begin position="435"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="TraI_2B" evidence="4">
        <location>
            <begin position="488"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="TraI" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1397" mass="152883" checksum="2D32BEB9AB17F5ED" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q327C1</accession>
    <name>Q327C1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stable inheritance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">stbB</name>
        <name evidence="2" type="ordered locus">SDY_P074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000445931.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406075.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327C1"/>
    <dbReference type="EnsemblBacteria" id="ABB64587">
        <property type="protein sequence ID" value="ABB64587"/>
        <property type="gene ID" value="SDY_P074"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P074"/>
    <dbReference type="HOGENOM" id="CLU_158505_0_0_6"/>
    <dbReference type="OMA" id="ITGLIMH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.290.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019720">
        <property type="entry name" value="Plasmid_stability_protein_StbB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038307">
        <property type="entry name" value="StbB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10784">
        <property type="entry name" value="Plasmid_stab_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="14809" checksum="2F8F907BC5269BD0" modified="2005-12-06" version="1">MESSDPKKRKKVVAYLHPALYPQDNLTQQTIDSLPVQMRGDFYRQSLICGAALYSVDPRLLTLISGFFSEKITAENLVKLIEQTTGYTSTSIDISVLKNIIEASSENKSESITSKDDFEEQTRRNLSMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q327G2</accession>
    <name>Q327G2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406034.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327G2"/>
    <dbReference type="EnsemblBacteria" id="ABB64546">
        <property type="protein sequence ID" value="ABB64546"/>
        <property type="gene ID" value="SDY_P033"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P033"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5573"/>
    <dbReference type="HOGENOM" id="CLU_036902_16_0_6"/>
    <dbReference type="OMA" id="CEFLANH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="161" mass="18326" checksum="88C8D8DAF2958C7D" modified="2005-12-06" version="1">MSEQKITGIDLAKTNFYLFSINAHGKPAGKTKLSRNQLLNWLVQQPKMTVAMEAGGASHYWAREIRKLDHDVILLPAQHVKAYQRCQKNDYNDAQAIAEACQHGTIRPVPIKTLEQQDVQTFLNMRRLVSMERTQLINHIRGLLAEYGIVFSKGAAELRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q327H7</accession>
    <name>Q327H7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001082153.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406019.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327H7"/>
    <dbReference type="EnsemblBacteria" id="ABB64530">
        <property type="protein sequence ID" value="ABB64530"/>
        <property type="gene ID" value="SDY_P017"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P017"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5553"/>
    <dbReference type="HOGENOM" id="CLU_2342483_0_0_6"/>
    <dbReference type="OMA" id="FVSGIHK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="95" mass="10539" checksum="772758449F1917DA" modified="2005-12-06" version="1">MNRTAFRAIHAVGADTGRNCRKFLPVSAGNFRIPFVINTYKPEDQFFVSGIHKERNIQVCATLNGIVKIIKAQNLSFFVTGSFKPSGLFPPAPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q327N7</accession>
    <name>Q327N7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerol transferase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mdoB</name>
        <name evidence="3" type="ordered locus">SDY_4613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327N7"/>
    <dbReference type="STRING" id="300267.SDY_4613"/>
    <dbReference type="EnsemblBacteria" id="ABB64468">
        <property type="protein sequence ID" value="ABB64468"/>
        <property type="gene ID" value="SDY_4613"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4613"/>
    <dbReference type="HOGENOM" id="CLU_023986_1_0_6"/>
    <dbReference type="OMA" id="AMNNTAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="150"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="750" mass="84174" checksum="A2E242DF79533249" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q327T6</accession>
    <name>DCTA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C4-dicarboxylate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dctA</name>
        <name type="ordered locus">SDY_4548</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000858220.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405910.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327T6"/>
    <dbReference type="SMR" id="Q327T6"/>
    <dbReference type="STRING" id="300267.SDY_4548"/>
    <dbReference type="EnsemblBacteria" id="ABB64419">
        <property type="protein sequence ID" value="ABB64419"/>
        <property type="gene ID" value="SDY_4548"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4548"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5376"/>
    <dbReference type="HOGENOM" id="CLU_019375_7_0_6"/>
    <dbReference type="OMA" id="YLYIAVI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006835">
        <property type="term" value="P:dicarboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01300">
        <property type="entry name" value="C4_dicarb_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023954">
        <property type="entry name" value="C4_dicarb_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0769">Symport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000067466" description="C4-dicarboxylate transport protein">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01300"/>
        </source>
    </evidence>
    <sequence length="428" mass="45494" checksum="3DB2384EBB601129" modified="2005-12-06" version="1">MKTSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVEVYADQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLGSIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDVLNNRAPDGKTHELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Y1</accession>
    <name>Q327Y1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nlpA</name>
        <name evidence="7" type="ordered locus">SDY_4499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000779403.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405865.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Y1"/>
    <dbReference type="STRING" id="300267.SDY_4499"/>
    <dbReference type="EnsemblBacteria" id="ABB64374">
        <property type="protein sequence ID" value="ABB64374"/>
        <property type="gene ID" value="SDY_4499"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4499"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5314"/>
    <dbReference type="HOGENOM" id="CLU_067080_0_0_6"/>
    <dbReference type="OMA" id="QDNKAHN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00363">
        <property type="entry name" value="TIGR00363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220936" description="Lipoprotein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="5">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002854-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="272" mass="29378" checksum="1DF525DBA3BB501E" modified="2005-12-06" version="1">MKLTTHHLRAGAALLLAGILLAGCDQSSSDAKHIKVGVINGAEQDVAEVAKKVAKEKYGLDVELVGFSGSLLPNDATNHGEPDANVFQHRPFLEQDNQAHGYKLVAVGNTFVFPMAGYSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKGLLPTALDITDNPRHLQIMELEGAQLPRVLDDPKVDVAIISTTYIQQTGLSPVHDSVFIEDKNSPYVNILVAREDNKNAENVKEFLQSYQSPEVAKAAETIFNGGAVPGW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q328L9</accession>
    <name>SYGB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="1">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyS</name>
        <name type="ordered locus">SDY_4345</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001291760.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405727.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328L9"/>
    <dbReference type="SMR" id="Q328L9"/>
    <dbReference type="STRING" id="300267.SDY_4345"/>
    <dbReference type="EnsemblBacteria" id="ABB64236">
        <property type="protein sequence ID" value="ABB64236"/>
        <property type="gene ID" value="SDY_4345"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4345"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5129"/>
    <dbReference type="HOGENOM" id="CLU_007220_2_2_6"/>
    <dbReference type="OMA" id="LPIPKRM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00255">
        <property type="entry name" value="Gly_tRNA_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015944">
        <property type="entry name" value="Gly-tRNA-synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30075">
        <property type="entry name" value="PTHR30075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02092">
        <property type="entry name" value="tRNA_synt_2f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01045">
        <property type="entry name" value="TRNASYNTHGB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00211">
        <property type="entry name" value="glyS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000006412" description="Glycine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00255"/>
        </source>
    </evidence>
    <sequence length="689" mass="76799" checksum="00891F7A3E243414" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q328U5</accession>
    <name>Q328U5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS system enzyme II, trehalose specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">treB</name>
        <name evidence="15" type="ordered locus">SDY_4259</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378955.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405651.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328U5"/>
    <dbReference type="STRING" id="300267.SDY_4259"/>
    <dbReference type="EnsemblBacteria" id="ABB64160">
        <property type="protein sequence ID" value="ABB64160"/>
        <property type="gene ID" value="SDY_4259"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4259"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5021"/>
    <dbReference type="HOGENOM" id="CLU_012312_2_0_6"/>
    <dbReference type="OMA" id="PMGVWNF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015574">
        <property type="term" value="F:trehalose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011296">
        <property type="entry name" value="PTS_IIBC_treh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01992">
        <property type="entry name" value="PTS-IIBC-Tre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="109"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB64160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="473" mass="51176" checksum="DD4F39C94DA9F694" modified="2005-12-06" version="1">MMSKINQTDIDRLIELVGGRGNIATVSHCITRLRFVLNQPANARPKEIEQLPMVKGCFTNAGQFQVVIGTNVGDYYQALIASTGQAQVDKEQVKKAARQNMKWHEQLISHFAEIFFPLLPALISGGLILGFRNVIGDLPMSNGQTLAQMYPSLQTIYDFLWLIGEAIFFYLPVGICWSAVKKMGGTPILGIVLGVTLVSPQLMNAYLLGQQLPEVWDFGMFSIAKVGYQAQVIPALLAGLALGVIETRLKRIVPDYLYLVVVPVCSLILAVFLAHALIGPFGRMIGDGVAFAVRHLMTGSFAPIGAALFGFLYAPLVITGVHQTTLAIDLQMIQSMGGTPVWPLIALSNIAQGSAVICIIISSRKHNEREISVPAAISAWLGVTEPAMYGINLKYRFPMLCAMIGSGLAGLLCGLNGVMANGIGVGGLPGILSIQPSYWQVFALAMVIAIIIPIVLTSFIYQRKYRLGTLDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q328W7</accession>
    <name>Q328W7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yjdG</name>
        <name evidence="5" type="ordered locus">SDY_4237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000611283.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405629.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328W7"/>
    <dbReference type="STRING" id="300267.SDY_4237"/>
    <dbReference type="EnsemblBacteria" id="ABB64138">
        <property type="protein sequence ID" value="ABB64138"/>
        <property type="gene ID" value="SDY_4237"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4237"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4991"/>
    <dbReference type="HOGENOM" id="CLU_000445_39_0_6"/>
    <dbReference type="OMA" id="DVHGLQL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="239" mass="27460" checksum="4C09AD596DBAC4DA" modified="2005-12-06" version="1">MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIFNSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVISSAADAATIKDSLHYGAVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIHGSSSNEQDPRRLPKGLTPQTLRTLCQWIDAHQDYEFSTDELANEVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRIQAEHYSLLKQYCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q329D4</accession>
    <name>Q329D4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yidJ</name>
        <name evidence="6" type="ordered locus">SDY_4162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000828469.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405562.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329D4"/>
    <dbReference type="STRING" id="300267.SDY_4162"/>
    <dbReference type="EnsemblBacteria" id="ABB64071">
        <property type="protein sequence ID" value="ABB64071"/>
        <property type="gene ID" value="SDY_4162"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4162"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4891"/>
    <dbReference type="HOGENOM" id="CLU_006332_9_2_6"/>
    <dbReference type="OMA" id="WGEHGLI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="5">
        <location>
            <begin position="385"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="497" mass="57321" checksum="290902F0D23396D3" modified="2005-12-06" version="1">MKRPNFLFIMTDTQATNMVGCYSGKPLNTQNIDSLAAEGIRFNSAYTCSPVCAPARAGLFTGIYANQSGPWTNNVALGKNISTMGRYFKDAGYHTCYIGKWHLDGHDYFGTGECPPEWDADYWFDGANYLSELTEKEISLWRNDLNSVEDLQANHIYETFTWAHRISNRAVDFLQQPARTEEPFLMVVSYDEPHHPFTCPVEYLEKYADFYYQLGEKAQDDLANKPEHHRLWAQAMPSPVGDDGLYHHPLYFACNDFVDDQIGRVINALTPEQRENTWVIYTSDHGEMMGAHKLISKGAAMYDDITRIPRIIRSPQGERRQVNTPVSHIDLLPTMMALADIEKPEILPGENILAVKEPCSVMVEFNRYEIEHDSFGGFIPVRCWVTDDFKLVLNLFTSDELYDRRNDPNEMHNLIDDAHFADVRSKMHDALLDYMDKIRDPFRSYQWSLRPWRKDAQPRWMGAFRPCPQDGYSPVVRDYDTGLPTQGVKVEEKKQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q329D5</accession>
    <name>Q329D5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yidI</name>
        <name evidence="2" type="ordered locus">SDY_4161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000511303.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405561.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329D5"/>
    <dbReference type="EnsemblBacteria" id="ABB64070">
        <property type="protein sequence ID" value="ABB64070"/>
        <property type="gene ID" value="SDY_4161"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4161"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4890"/>
    <dbReference type="HOGENOM" id="CLU_144193_0_0_6"/>
    <dbReference type="OMA" id="AGACKEN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016512">
        <property type="entry name" value="Uncharacterised_IM_YidI"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007312">
        <property type="entry name" value="Inner_membrane_protein_YidI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="149" mass="15800" checksum="8B316DE222B7042F" modified="2005-12-06" version="1">MGIIAQNKISSLGMLFGAIALMMGIIHFSFGPFSAPPPTLESIVADKTAEIKRGLLAGIKGEKITTVERKEDVDVDKILDQSGIALAIAALLCAFISGMRKENRWGIRGALVFGGGTLAFHTLLFGICIVCSILLIFLIFSFLTGGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q329F3</accession>
    <name>Q329F3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405543.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329F3"/>
    <dbReference type="EnsemblBacteria" id="ABB64052">
        <property type="protein sequence ID" value="ABB64052"/>
        <property type="gene ID" value="SDY_4142"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4142"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4869"/>
    <dbReference type="HOGENOM" id="CLU_132631_2_0_6"/>
    <dbReference type="OMA" id="QDMANID"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009387">
        <property type="entry name" value="HigB-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06296">
        <property type="entry name" value="RelE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018634">
        <property type="entry name" value="UCP018634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13711" checksum="195DA9038C9E0002" modified="2005-12-06" version="1">MRVFKTKWFAREARSHAITDEELCRAILETEQGKADALGGGVFKKRLHQNRERAIILAKGGSNWFYTFLYAKQDMSNINSQELAGFRELAKHYAFLTKAQLTAMINTKELTEICYDCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q329G1</accession>
    <name>Q329G1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_4134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405535.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329G1"/>
    <dbReference type="STRING" id="300267.SDY_4134"/>
    <dbReference type="EnsemblBacteria" id="ABB64044">
        <property type="protein sequence ID" value="ABB64044"/>
        <property type="gene ID" value="SDY_4134"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4134"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4859"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_6"/>
    <dbReference type="OMA" id="AVHIRHI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="138"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="241" mass="26795" checksum="2F98DE85F4B2D079" modified="2005-12-06" version="1">MMRSVTMKPVVLVVDDDTAICALLQDVLSEHVFTVSVCHTGQEAILRIEGDPDIALVVLDMMLPDTNGLRVLQQIQKLRPTLPVVMLTGMGSKSDVVVGLEMGADDYICKPFTPRVVVARLKAVLRRVGALAVNDEKSAGLSFNGWYLDTMRCQLHNPLQQHVELTQGEYGLLLALAQNASRVLSREQLLAFTHSDSVEVFDRTIDVLIMRLRRKIELNPHQPMLIKTLRGLGYVFAADVH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q329L4</accession>
    <name>PYRE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="1">OPRT</shortName>
            <shortName evidence="1">OPRTase</shortName>
            <ecNumber evidence="1">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrE</name>
        <name type="ordered locus">SDY_4073</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000806179.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405482.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329L4"/>
    <dbReference type="SMR" id="Q329L4"/>
    <dbReference type="STRING" id="300267.SDY_4073"/>
    <dbReference type="EnsemblBacteria" id="ABB63991">
        <property type="protein sequence ID" value="ABB63991"/>
        <property type="gene ID" value="SDY_4073"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4073"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4792"/>
    <dbReference type="HOGENOM" id="CLU_074878_0_1_6"/>
    <dbReference type="OMA" id="MKAYQRQ"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00103">
        <property type="entry name" value="PUR_PYR_PR_TRANSFER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000066296" description="Orotate phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="124"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <sequence length="213" mass="23495" checksum="F618A6D0A2AF59D4" modified="2005-12-06" version="1">MKPYQRQFIEFALSKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDLDLPYCFNRKEAKDHGEGGNLVGSALQGRVMLVDDVITAGTAIRESMEIIQANGATLAGVLISLDRQERGRGEISAIQEVERDYNCKVISIITLKDLIAYLEGKPEMAEHLAAVKAYREEFGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q329P6</accession>
    <name>GPDA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="1">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpsA</name>
        <name type="ordered locus">SDY_4041</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001076194.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405450.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329P6"/>
    <dbReference type="SMR" id="Q329P6"/>
    <dbReference type="STRING" id="300267.SDY_4041"/>
    <dbReference type="EnsemblBacteria" id="ABB63959">
        <property type="protein sequence ID" value="ABB63959"/>
        <property type="gene ID" value="SDY_4041"/>
    </dbReference>
    <dbReference type="GeneID" id="66672494"/>
    <dbReference type="KEGG" id="sdy:SDY_4041"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4756"/>
    <dbReference type="HOGENOM" id="CLU_033449_0_2_6"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000255369" description="Glycerol-3-phosphate dehydrogenase [NAD(P)+]">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <sequence length="339" mass="36362" checksum="DF95F674204276BE" modified="2005-12-06" version="1">MNQRNASMTVIGAGSYGTALAITLARNGHEVVLWGHDPEHIATLERDRCNAAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFGEVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDQTFADDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVQSAQEKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKDERSSH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q329V3</accession>
    <name>ILVC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="1">KARI</shortName>
            <ecNumber evidence="1">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="1">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ketol-acid reductoisomerase type 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ketol-acid reductoisomerase type II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ilvC</name>
        <name type="ordered locus">SDY_3974</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016877.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405393.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329V3"/>
    <dbReference type="SMR" id="Q329V3"/>
    <dbReference type="STRING" id="300267.SDY_3974"/>
    <dbReference type="EnsemblBacteria" id="ABB63902">
        <property type="protein sequence ID" value="ABB63902"/>
        <property type="gene ID" value="SDY_3974"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3974"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4687"/>
    <dbReference type="HOGENOM" id="CLU_551905_0_0_6"/>
    <dbReference type="OMA" id="CGLLQTG"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000226200" description="Ketol-acid reductoisomerase (NADP(+))">
        <location>
            <begin position="1"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="2">
        <location>
            <begin position="15"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted 1" evidence="3">
        <location>
            <begin position="209"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted 2" evidence="3">
        <location>
            <begin position="345"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <sequence length="491" mass="54050" checksum="8E4EE7DEDB6B7E89" modified="2005-12-06" version="1">MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSDVVRTVQPLMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVEEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNAQLHDVNEAIRSHAIEQVGKKLRGYMTDMKRIAVAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q329X3</accession>
    <name>WECG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetyl-D-mannosaminuronic acid transferase</fullName>
            <shortName evidence="1">UDP-ManNAcA transferase</shortName>
            <ecNumber evidence="1">2.4.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">wecG</name>
        <name evidence="1" type="synonym">rffM</name>
        <name type="ordered locus">SDY_3953</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate = beta-D-ManNAcA-(1-&gt;4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:28366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61495"/>
            <dbReference type="ChEBI" id="CHEBI:62959"/>
            <dbReference type="ChEBI" id="CHEBI:70731"/>
            <dbReference type="EC" id="2.4.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 26 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.180" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001064038.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405373.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329X3"/>
    <dbReference type="SMR" id="Q329X3"/>
    <dbReference type="STRING" id="300267.SDY_3953"/>
    <dbReference type="CAZy" id="GT26">
        <property type="family name" value="Glycosyltransferase Family 26"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63882">
        <property type="protein sequence ID" value="ABB63882"/>
        <property type="gene ID" value="SDY_3953"/>
    </dbReference>
    <dbReference type="GeneID" id="66672302"/>
    <dbReference type="KEGG" id="sdy:SDY_3953"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4664"/>
    <dbReference type="HOGENOM" id="CLU_063203_3_2_6"/>
    <dbReference type="OMA" id="PWRWRRM"/>
    <dbReference type="UniPathway" id="UPA00566"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047241">
        <property type="term" value="F:lipopolysaccharide N-acetylmannosaminouronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009246">
        <property type="term" value="P:enterobacterial common antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01001">
        <property type="entry name" value="WecG_RffM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023085">
        <property type="entry name" value="UDP-ManNAcA_Trfase_WecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000062732" description="UDP-N-acetyl-D-mannosaminuronic acid transferase">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01001"/>
        </source>
    </evidence>
    <sequence length="246" mass="27962" checksum="CE98CA2DA6A69535" modified="2005-12-06" version="1">MNNNTTAPTYTLRGLQLIGWRDMQHALDYLFADGQLKQGTLVAINAEKMLTIEDNAEVRELINAAEFKYADGISVVRSVRKKYPQAQVSRVAGADLWEELMARAGKEGTPVFLVGGKPEVLAQTEAKLRNQWNVNIVGSQDGYFKPEQRQALFERIHASGAQIVTVAMGSPKQEIFMRDCRLVHPDALYMGVGGTYDVFTGHVKRAPKIWQTLGLEWLYRLLSQPSRIKRQLRLLRYLRWHYTGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q329X7</accession>
    <name>Q329X7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">A late step of protoheme IX synthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hemY</name>
        <name evidence="14" type="ordered locus">SDY_3944</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in a late step of protoheme IX synthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000921781.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405369.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329X7"/>
    <dbReference type="STRING" id="300267.SDY_3944"/>
    <dbReference type="EnsemblBacteria" id="ABB63878">
        <property type="protein sequence ID" value="ABB63878"/>
        <property type="gene ID" value="SDY_3944"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3944"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4655"/>
    <dbReference type="HOGENOM" id="CLU_037501_2_0_6"/>
    <dbReference type="OMA" id="WGKARDY"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042168">
        <property type="term" value="P:heme metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005254">
        <property type="entry name" value="Heme_biosyn_assoc_TPR_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010817">
        <property type="entry name" value="HemY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07219">
        <property type="entry name" value="HemY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00540">
        <property type="entry name" value="TPR_hemY_coli"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="HemY_N" evidence="13">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB63878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="398" mass="45202" checksum="D87C3050D8E022DD" modified="2005-12-06" version="1">MLKVLLLFVLLIAGIVVGPMIAGHQGYVLIQTDNYNIETSVTGLAIILILAMVVLFAIEWLLRRIFRTGAHTRGWFVGRKRRRARKQTEQALLKLAEGDYQQVEKLMAKNADHAEQPVVNYLLAAEAAQQRGDEARANQHLERAAELAGNDTIPVEITRVRLQLARNENHAARHGVDKLLEVTPLHPEVLRLAEQAYIRTGAWSSLLDIIPSMAKAHVGDEEHRAMLEQQAWIGLMDQARADNGSEGLRNWWKNQSRKTRHQVALQVAMAEHLIECDDHDTAQQIIIDGLKRQYDDRLLLPIPRLKTNNPEQLEKVLRQQIKNVGDRPLLWSTLGQSLMKHGEWQEASLAFRAALKQRPDAYDYAWLADALDRLHKPEEAAAMRRDGLMLTLQNNPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A03</accession>
    <name>Q32A03_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L(2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pldB</name>
        <name evidence="2" type="ordered locus">SDY_3918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000487656.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405343.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A03"/>
    <dbReference type="STRING" id="300267.SDY_3918"/>
    <dbReference type="ESTHER" id="shifl-PLDB">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63852">
        <property type="protein sequence ID" value="ABB63852"/>
        <property type="gene ID" value="SDY_3918"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3918"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4626"/>
    <dbReference type="HOGENOM" id="CLU_026209_10_1_6"/>
    <dbReference type="OMA" id="AFDWRGQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="51"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="340" mass="38994" checksum="A032DB16DC123C05" modified="2005-12-06" version="1">MFQQQKDWETRENAFAAFTMGPLTDFWRQRDEAEFTGVDDIPVRFVRFRAQHHDRVVVICPGRIESYVKYAELAYDLFHLGFDVLIIDHRGQGRSGRLLADPHLGHVNRFNDYVDDLAAFWQQEVQPGPWRKRYILAHSMGGAISTLFLQRHPGVCDAIALTAPMFGIVIRMPSFMARQILNWAEAHPRFRDGYAIGTGRWRALPFAINVLTHSRQRYRRNLRFYADDPTIRVGGPTYHWVRESILAGEQVLAGAGDDATPTLLLQAEEERVVDNRMHDRFCELRTAAGHPVEGGRPLVIKGAYHEILFEKDSMRSVALHAIVDFFNRHNSPSGNRSTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A81</accession>
    <name>Q32A81_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Periplasmic sulfate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sbp</name>
        <name evidence="8" type="ordered locus">SDY_3830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001045704.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405265.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A81"/>
    <dbReference type="STRING" id="300267.SDY_3830"/>
    <dbReference type="EnsemblBacteria" id="ABB63774">
        <property type="protein sequence ID" value="ABB63774"/>
        <property type="gene ID" value="SDY_3830"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3830"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4523"/>
    <dbReference type="HOGENOM" id="CLU_055615_0_1_6"/>
    <dbReference type="OMA" id="KDFGGWK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901681">
        <property type="term" value="F:sulfur compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01005">
        <property type="entry name" value="PBP2_CysP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000957">
        <property type="entry name" value="Sulphate/thiosulphate-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034408">
        <property type="entry name" value="Sulphate/thiosulphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00401">
        <property type="entry name" value="PROK_SULFATE_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00757">
        <property type="entry name" value="PROK_SULFATE_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220845" evidence="7">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="329" mass="36689" checksum="7F92DF159185CD19" modified="2005-12-06" version="1">MNKWGVGLTFLLATTSVMAKDIQLLNVSYDPTRELYEQYNKAFSAHWKQQTGDNVVIRQSHGGSGKQATSVINGIEADVVTLALAYDVDAIAERGRIDKEWIKRLPDNSAPYTSTIVFLVRKGNPKQIHDWNDLIKPGVSVITPNPKSSGGARWNYLAAWGYALHHNNNDQAKAQDFVRALYKNVEVLDSGARGSTNTFVERGIGDVLIAWENEALLAANELGKDKFEIVTPSESILAEPTVSVVDKVVEKKGTKEVAEAYLKYLYSPEGQEIAAKNYYRPRDAEVAKKYENAFPKLKLFTIDEEFGGWTKAQKEHFANGGTFDQISKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A92</accession>
    <name>GLPK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol kinase</fullName>
            <ecNumber evidence="1">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycerokinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glpK</name>
        <name type="ordered locus">SDY_3818</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Activity of this regulatory enzyme is affected by several metabolites. Allosterically and non-competitively inhibited by fructose 1,6-bisphosphate (FBP) and unphosphorylated phosphocarrier protein EIIA-Glc (III-Glc), an integral component of the bacterial phosphotransferase (PTS) system.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer and homodimer (in equilibrium). Heterodimer with EIIA-Glc. Binds 1 zinc ion per glycerol kinase EIIA-Glc dimer. The zinc ion is important for dimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000136815.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405254.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A92"/>
    <dbReference type="SMR" id="Q32A92"/>
    <dbReference type="STRING" id="300267.SDY_3818"/>
    <dbReference type="PRIDE" id="Q32A92"/>
    <dbReference type="EnsemblBacteria" id="ABB63763">
        <property type="protein sequence ID" value="ABB63763"/>
        <property type="gene ID" value="SDY_3818"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3818"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4509"/>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_6"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0319">Glycerol metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000020787" description="Glycerol kinase">
        <location>
            <begin position="1"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="412"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with EIIA-Glc</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <sequence length="502" mass="56230" checksum="1BD28874DFA1351A" modified="2005-12-06" version="1">MTEKKYIVALDQGTTSSRAVVMNHDANIISVSQREFEQIYPKPGWVEHDPMEIWATQSSTLVEVLAKADISSDQIAAIGITNQRETTIVWEKETGKPIYNAIVWQCRRTAEICEHLKRDGLEDYIRSNTGLVIDPYFSGTKVKWILDHVEGSRERARRGELLFGTVDTWLIWKMTQGRVHVTDYTNASRTMLFNIHTLDWDDKMLEVLDIPREMLPEVRRSSEVYGQTNIGGKGGTRIPISGIAGDQQAALFGQLCVKEGMAKNTYGTGCFMLMNTGEKAVKSENGLLTTIACGPTGEVNYALEGAVFMAGASIQWLRDEMKLINDAYDSEYFATKVQNTNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGVNANHIIRATLESIAYQTRDVLEAMQADSGIRLHALRVDGGAVANNFLMQFQSDILGTRVERPEVREVTALGAAYLAGLAVGFWQNLDELQEKAVIEREFRPGIETTERNYRYAGWKKAVKRAMAWEEHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A96</accession>
    <name>Q32A96_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A96"/>
    <dbReference type="EnsemblBacteria" id="ABB63759">
        <property type="protein sequence ID" value="ABB63759"/>
        <property type="gene ID" value="SDY_3814"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3814"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="WSAPAYQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27454" checksum="163C167DB03754A5" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQSGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPVAFREKYHQMAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AA9</accession>
    <name>RL31_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmE</name>
        <name type="ordered locus">SDY_3801</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000710769.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405237.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AA9"/>
    <dbReference type="SMR" id="Q32AA9"/>
    <dbReference type="STRING" id="300267.SDY_3801"/>
    <dbReference type="EnsemblBacteria" id="ABB63746">
        <property type="protein sequence ID" value="ABB63746"/>
        <property type="gene ID" value="SDY_3801"/>
    </dbReference>
    <dbReference type="GeneID" id="66672156"/>
    <dbReference type="KEGG" id="sdy:SDY_3801"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4491"/>
    <dbReference type="HOGENOM" id="CLU_114306_4_3_6"/>
    <dbReference type="OMA" id="WYPDAKV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000259228" description="50S ribosomal protein L31">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <sequence length="70" mass="7871" checksum="D657A681A0B858CF" modified="2005-12-06" version="1">MKKDIHPKYEEITASCSCGNVMKIRSTVGHDLNLDVCSKCHPFFTGKQRDVATGGRVDRFNKRFNIPGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AE2</accession>
    <name>Q32AE2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_3766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AE2"/>
    <dbReference type="STRING" id="300267.SDY_3766"/>
    <dbReference type="EnsemblBacteria" id="ABB63713">
        <property type="protein sequence ID" value="ABB63713"/>
        <property type="gene ID" value="SDY_3766"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3766"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8209" checksum="5770A9F104DCE4BE" modified="2005-12-06" version="1">MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGGWMPGNCTHYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AI9</accession>
    <name>Q32AI9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405157.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AI9"/>
    <dbReference type="EnsemblBacteria" id="ABB63666">
        <property type="protein sequence ID" value="ABB63666"/>
        <property type="gene ID" value="SDY_3705"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3705"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4397"/>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_6"/>
    <dbReference type="OMA" id="CKEHINS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="233" mass="27063" checksum="21ADF9333AD57277" modified="2005-12-06" version="1">MAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITLHFEVKAPDNDPRWLTHLSVPQQTKVVDPQALVALFRQFLSEQEKHQRTPALEFIVLLILQQLTRDARLDEQADGAGTTLAWKAQKLIRTQYHRPLSTALLARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCEFNDVGYFRQIFRKHTGLTPAAWKRRYSKEHINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AN5</accession>
    <name>Q32AN5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Repressor of the glp operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpR</name>
        <name evidence="5" type="ordered locus">SDY_3652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000815099.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405111.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AN5"/>
    <dbReference type="SMR" id="Q32AN5"/>
    <dbReference type="STRING" id="300267.SDY_3652"/>
    <dbReference type="EnsemblBacteria" id="ABB63620">
        <property type="protein sequence ID" value="ABB63620"/>
        <property type="gene ID" value="SDY_3652"/>
    </dbReference>
    <dbReference type="GeneID" id="67417050"/>
    <dbReference type="KEGG" id="sdy:SDY_3652"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4334"/>
    <dbReference type="HOGENOM" id="CLU_060699_0_0_6"/>
    <dbReference type="OMA" id="STHEPGF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="252" mass="28048" checksum="D547569200AFB6B3" modified="2005-12-06" version="1">MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPSSSVNTPWHDRKATQTEEKERIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATLDFISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPPVSVMQVLTDHHIQLELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AT0</accession>
    <name>Q32AT0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding component of high-affinity branched-chain amino acid transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livG</name>
        <name evidence="5" type="ordered locus">SDY_3604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000082100.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405066.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AT0"/>
    <dbReference type="STRING" id="300267.SDY_3604"/>
    <dbReference type="EnsemblBacteria" id="ABB63575">
        <property type="protein sequence ID" value="ABB63575"/>
        <property type="gene ID" value="SDY_3604"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3604"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4280"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_6"/>
    <dbReference type="OMA" id="EHDMRFI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="255" mass="28459" checksum="CDEC2F344DF7CA85" modified="2005-12-06" version="1">MSQPLLSVNGLMMRFGGLLAVNNVNLELYPQEIVSLIGPNGAGKTTVFNCLTGFYKPTGGTILLRDQHLEGLPGQQIARMGVVRTFQHVRLFREMTVIENLLVAQHQQLKTGLFSGLLKTPSFRRAQSEALDRAATWLERIGLLEHANRQASNLAYGDQRRLEIARCMVTQPEILMLDEPAAGLNPKETKELDELIAELRNHHNTTILLIEHDMKLVMGISDRIYVVNQGTPLANGTPEQIRNNPDMIRAYLGEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AT3</accession>
    <name>UGPB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>sn-glycerol-3-phosphate-binding periplasmic protein UgpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ugpB</name>
        <name type="ordered locus">SDY_3601</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">sn-glycerol-3-phosphate and glycerophosphoryl diester-binding protein interacts with the binding protein-dependent transport system UgpACE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000803212.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405063.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AT3"/>
    <dbReference type="SMR" id="Q32AT3"/>
    <dbReference type="STRING" id="300267.SDY_3601"/>
    <dbReference type="EnsemblBacteria" id="ABB63572">
        <property type="protein sequence ID" value="ABB63572"/>
        <property type="gene ID" value="SDY_3601"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3601"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4276"/>
    <dbReference type="HOGENOM" id="CLU_031285_3_0_6"/>
    <dbReference type="OMA" id="ESFSAWH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000292817" description="sn-glycerol-3-phosphate-binding periplasmic protein UgpB">
        <location>
            <begin position="24"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="438" mass="48419" checksum="5537EAA67A77D064" modified="2005-12-06" version="1" precursor="true">MKPLHYTASALALGLALMGNAQAVTTIPFWHSMEGELGKEVDSLAQRFNAENPDYKIVPTYKGNYEQNLSAGIAAFRTGNAPAILQVYEVGTATMMASKAIQPVYDVFKEAGIQFDESQFVPTVSGYYSDSKTGHLLSQPFNSSTPVLYYNKDAFKKAGLDPEQPPKTWQDLADYAAKLKASGMKCGYASGWQGRIQLENFSAWNGLPFASKNNGFDGTDAVLEFNKPEQVKHIAMLEEMNKKGDFSYVGRKDESTEKFYNGDCAMTTASSGSLANIREYAKFNYGVGMMPYDADAKDAPQNAIIGGASLWVMQGKDKETYTGVAKFLDFLAKPENAAEWHQKTGYLPITKAAYDLTREQGFYEKNPGADTATRQMLNKPPLPFTKGLRLGNMPQIRVIVDEELESVWTGKKTPQQALDTAVERGNQLLRRFEKSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AX1</accession>
    <name>Q32AX1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arsenical pump membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">arsB</name>
        <name evidence="7" type="ordered locus">SDY_3560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405025.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AX1"/>
    <dbReference type="EnsemblBacteria" id="ABB63534">
        <property type="protein sequence ID" value="ABB63534"/>
        <property type="gene ID" value="SDY_3560"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3560"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4225"/>
    <dbReference type="HOGENOM" id="CLU_043931_1_0_6"/>
    <dbReference type="OMA" id="AMTTVWL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01118">
        <property type="entry name" value="ArsB_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00935">
        <property type="entry name" value="2a45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="436" mass="46277" checksum="43F808476D78CC6F" modified="2005-12-06" version="1">MFYPGGIMLLAGAIFVLTIVLVIWQPKGLGIGWAATLGAVLALVTGVVHPGDIPVVWNIIWNATAAFIAVIIISLLLDESGFFEWAALHVSRWGNGRGRLLFTWIVLLGAAVAALFANDGAALILTPIVIAMLLALGFSKGTTLVFVMAAGFIADTASLPLIVSNLVNIVSADFFGLGFREYASVMVPVDIAAIVATLVMLHLYFRKDIPQNYDMALLKSPAEAIKDPATFKTGWVVLLLLLVGFFVLEPLGIPVSAIAAVGALTLFVVAKRGHAINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTEYLSGVLNVLADNGLWAATLGTGFLTAFLSSIMNNMPTVLVGALSIDGSTASGVIKEAMVYANVIGCDLGPKITPIGSLATLLWLHVLSQKNMTISWGYYFRTGIIMTLPVLFVTLAALALRLSFTL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AY3</accession>
    <name>HMUV_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemin import ATP-binding protein HmuV</fullName>
            <ecNumber evidence="1">7.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hmuV</name>
        <name type="synonym">shuV</name>
        <name type="ordered locus">SDY_3547</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (HmuV), two transmembrane proteins (HmuU) and a solute-binding protein (HmuT).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001626196.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405013.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AY3"/>
    <dbReference type="SMR" id="Q32AY3"/>
    <dbReference type="STRING" id="300267.SDY_3547"/>
    <dbReference type="TCDB" id="3.A.1.14.18">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63522">
        <property type="protein sequence ID" value="ABB63522"/>
        <property type="gene ID" value="SDY_3547"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3547"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4209"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_6"/>
    <dbReference type="OMA" id="KALCQEI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51261">
        <property type="entry name" value="HMUV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000269627" description="Hemin import ATP-binding protein HmuV">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01718"/>
        </source>
    </evidence>
    <sequence length="256" mass="28896" checksum="1A19D57B17E719D8" modified="2005-12-06" version="1">MISAQNLVYSLQGRRLTDNVSLTFPGGEIVAILGPNGAGKSTLLRQLTGYLQPDSGECRLFNKPLNEWSITELAKHRAVMRQNSHMAFPFSVQEVIQMGRHPHRTGNQDNETAQIMALCDCQALANRDYRQLSGGEQQRVQLARLLVQLWEPTPSPKWLFLDEPTSALDIHHQQHLFRLLRQLVHERQFNVCCVLHDLNLAARYADRIVLMQKGKVIANGKPQDVLTQQALTMLYGADITVLEDPANHSPLIVLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AZ1</accession>
    <name>Q32AZ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhiU</name>
        <name evidence="6" type="ordered locus">SDY_3538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001081792.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405005.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AZ1"/>
    <dbReference type="STRING" id="300267.SDY_3538"/>
    <dbReference type="EnsemblBacteria" id="ABB63514">
        <property type="protein sequence ID" value="ABB63514"/>
        <property type="gene ID" value="SDY_3538"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3538"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4197"/>
    <dbReference type="HOGENOM" id="CLU_018816_2_1_6"/>
    <dbReference type="OMA" id="RHFEEGQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220857" evidence="3">
        <location>
            <begin position="22"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="4">
        <location>
            <begin position="34"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="59"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="384" mass="41006" checksum="84209C5DB4E08A44" modified="2005-12-06" version="1">MNRRKLLIPLLFCGAMLTACDDKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINLQYANVTSPITGASGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVASGQIKQVQGSTPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISSSQENASTESKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BE2</accession>
    <name>Q32BE2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yrbB</name>
        <name evidence="2" type="ordered locus">SDY_3372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BE2"/>
    <dbReference type="STRING" id="300267.SDY_3372"/>
    <dbReference type="EnsemblBacteria" id="ABB63363">
        <property type="protein sequence ID" value="ABB63363"/>
        <property type="gene ID" value="SDY_3372"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3372"/>
    <dbReference type="HOGENOM" id="CLU_115403_13_4_6"/>
    <dbReference type="OMA" id="NPLWDAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="46"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="129" mass="14350" checksum="5969F609D80B3BCC" modified="2005-12-06" version="1">MGNAAAYQRYRRPDCATEIDFSTENHSGREKIMSESLSWMQTGDTLALSGELDQDVLLPLWEMREEAVKGITCIDLSRVSRVDTGGLALLLHLIDLAKKQGNNVTLQGVNDKVYTLAKLYNLPADVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BN4</accession>
    <name>Q32BN4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GFO_IDH_MocA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygjR</name>
        <name evidence="2" type="ordered locus">SDY_3272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404762.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BN4"/>
    <dbReference type="STRING" id="300267.SDY_3272"/>
    <dbReference type="EnsemblBacteria" id="ABB63271">
        <property type="protein sequence ID" value="ABB63271"/>
        <property type="gene ID" value="SDY_3272"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3272"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3913"/>
    <dbReference type="HOGENOM" id="CLU_023194_7_0_6"/>
    <dbReference type="OMA" id="FINYCQY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="334" mass="37094" checksum="7D75E3A610E47499" modified="2005-12-06" version="1">MEYPRVMIRFAVIGTNWITRQFVEAAHESGKYKLTAVYSRSLEQAQHFVNDFSVEHLFTSLEAMAESDAIDAVYIASPNSLHFSQTQLFLSHKIHVICEKPLASNLAEVDAAIACARENQVVLFEAFKTTSLPNFHLLRQALPKVGKLRKVFFNYCQYSSRYQRYLDGENPNTFNPAFSNGSIMDIGFYCLASAVALFGEPKSVQATASLLASGVDAHGVVVMDYGDFSVILQHSKVSDSVMASEIQGEAGSLVIEKLSECQKVCFVPRGSQMQDLTQPQHINTMLYEAELFATLVDEHLVDHPGLAVSRITAKLLTEIRRQTGVIFPADSVKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BV2</accession>
    <name>IDI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="1">IPP isomerase</shortName>
            <ecNumber evidence="1">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">idi</name>
        <name type="ordered locus">SDY_3193</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001192818.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404694.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BV2"/>
    <dbReference type="SMR" id="Q32BV2"/>
    <dbReference type="STRING" id="300267.SDY_3193"/>
    <dbReference type="EnsemblBacteria" id="ABB63203">
        <property type="protein sequence ID" value="ABB63203"/>
        <property type="gene ID" value="SDY_3193"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3193"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3815"/>
    <dbReference type="HOGENOM" id="CLU_060552_2_0_6"/>
    <dbReference type="OMA" id="FPLRWAN"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000227128" description="Isopentenyl-diphosphate Delta-isomerase">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase">
        <location>
            <begin position="30"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <sequence length="182" mass="20539" checksum="B48B22A9F667CC2D" modified="2005-12-06" version="1">MQTEHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPNGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLRGIDATPWAFSPWMVMQATNREARIRLSAFTQLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C17</accession>
    <name>YQGE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0301 protein YqgE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqgE</name>
        <name type="ordered locus">SDY_3124</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63138" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63138.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001053178.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404629.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C17"/>
    <dbReference type="SMR" id="Q32C17"/>
    <dbReference type="STRING" id="300267.SDY_3124"/>
    <dbReference type="EnsemblBacteria" id="ABB63138">
        <property type="protein sequence ID" value="ABB63138"/>
        <property type="gene ID" value="SDY_3124"/>
    </dbReference>
    <dbReference type="GeneID" id="67415160"/>
    <dbReference type="KEGG" id="sdy:SDY_3124"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3734"/>
    <dbReference type="HOGENOM" id="CLU_057596_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000258882" description="UPF0301 protein YqgE">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="187" mass="20686" checksum="8ACCCCACABF4E025" modified="2006-10-31" version="2">MNLQHHFLIAMPALQDPIFRRSVVYICEHNTNGAMGIIVNKPLENLKIEGILEKLKITPEPRDESIRLDKPVMLGGPLAEDRGFILHTPPSNFASSIRISDNTVMTTSRDVLETLGTDKQPSDVLVALGYASWEKGQLEQEILDNAWLTAPADLNILFKTPIADRWREAAKLIGVDILTMPGVAGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C19</accession>
    <name>Q32C19_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T2SP_E domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yggR</name>
        <name evidence="3" type="ordered locus">SDY_3121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404627.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C19"/>
    <dbReference type="STRING" id="300267.SDY_3121"/>
    <dbReference type="EnsemblBacteria" id="ABB63135">
        <property type="protein sequence ID" value="ABB63135"/>
        <property type="gene ID" value="SDY_3121"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3121"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3732"/>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_6"/>
    <dbReference type="OMA" id="WELDCSY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="341" mass="37571" checksum="9DE4DFAE2E582AA4" modified="2005-12-06" version="1">MPGYAQYRSFSEDLSMNMEEIVALSVKHNVSDLHLCSARPARWRIRGLMEAAPFDAPDVEELLREWLDDDQRAILLENGQLDFAVSLAENQRLRGSAFAQRHGISLALRLLPSHCPQLEQLGAPTVLPELLKSENGLILVTGATGSGKSTTLAAMVGYLNQHADAHILTLADPVEYLYASQRCLIQQREIGLHCMTFASGLRAALREDPDVILLGELRDSETIRLALTAAETGHLVLATLHTRGAAQAVERLVDSFPAQEKDPVRNQLAGSLRAVLSQKLEVDKQEGRVALFELLINTPAVGNLIREGKTHQLPHVIQTGQQVGMITFQQSYQQRVAEGRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C68</accession>
    <name>YQHA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0114 protein YqhA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqhA</name>
        <name type="ordered locus">SDY_3070</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0114 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018224.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404578.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C68"/>
    <dbReference type="STRING" id="300267.SDY_3070"/>
    <dbReference type="EnsemblBacteria" id="ABB63087">
        <property type="protein sequence ID" value="ABB63087"/>
        <property type="gene ID" value="SDY_3070"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3070"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3675"/>
    <dbReference type="HOGENOM" id="CLU_097887_1_1_6"/>
    <dbReference type="OMA" id="HTIMWQV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00143">
        <property type="entry name" value="UPF0114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005134">
        <property type="entry name" value="UPF0114"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020761">
        <property type="entry name" value="UPF0114_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38596">
        <property type="entry name" value="PTHR38596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03350">
        <property type="entry name" value="UPF0114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00645">
        <property type="entry name" value="HI0507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000009500" description="UPF0114 protein YqhA">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00143"/>
        </source>
    </evidence>
    <sequence length="164" mass="18640" checksum="915C04BA8B8F404F" modified="2005-12-06" version="1">MERFLENAMYASRWLLAPVYFGLSLALVALALKFFQEIIHVLPNIFSMAESDLILVLLSLVDMTLVGGLLVMVMFSGYENFVSQLDISKNKEKLNWLGKMDATSLKNKVAASIVAISSIHLLRVFMDAKNVPDNKLMWYVIIHLTFVLSAFVMGYLDRLTRHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CG0</accession>
    <name>Q32CG0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ygcO</name>
        <name evidence="4" type="ordered locus">SDY_2969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Could be a 3Fe-4S cluster-containing protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial-type ferredoxin family. FixX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404486.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CG0"/>
    <dbReference type="STRING" id="300267.SDY_2969"/>
    <dbReference type="EnsemblBacteria" id="ABB62995">
        <property type="protein sequence ID" value="ABB62995"/>
        <property type="gene ID" value="SDY_2969"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2969"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3561"/>
    <dbReference type="HOGENOM" id="CLU_163428_1_0_6"/>
    <dbReference type="OMA" id="WLINACP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012206">
        <property type="entry name" value="Fd_FixX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43082">
        <property type="entry name" value="PTHR43082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036548">
        <property type="entry name" value="Fdx_FixX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="98" mass="10868" checksum="6A15802E9519D5BF" modified="2005-12-06" version="1">MASGGRCYQESAMSVARNLWRVADAPHIVPADSVERQTVQRLINACPAGLFSLTPEGDLRVDYHGCLECGTCRLLCDESTLQQWRYPPSGFGITYRFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CI4</accession>
    <name>ISPF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="1">MECDP-synthase</shortName>
            <shortName evidence="1">MECPP-synthase</shortName>
            <shortName evidence="1">MECPS</shortName>
            <ecNumber evidence="1">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispF</name>
        <name type="ordered locus">SDY_2945</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspF family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001219242.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404462.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CI4"/>
    <dbReference type="SMR" id="Q32CI4"/>
    <dbReference type="STRING" id="300267.SDY_2945"/>
    <dbReference type="EnsemblBacteria" id="ABB62971">
        <property type="protein sequence ID" value="ABB62971"/>
        <property type="gene ID" value="SDY_2945"/>
    </dbReference>
    <dbReference type="GeneID" id="67413962"/>
    <dbReference type="KEGG" id="sdy:SDY_2945"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3537"/>
    <dbReference type="HOGENOM" id="CLU_084630_2_0_6"/>
    <dbReference type="OMA" id="QHFGTGR"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000237753" description="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="100"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <sequence length="159" mass="16898" checksum="9FC5563623A62939" modified="2005-12-06" version="1">MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CR3</accession>
    <name>Q32CR3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ygaU</name>
        <name evidence="3" type="ordered locus">SDY_2855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000522415.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404383.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CR3"/>
    <dbReference type="SMR" id="Q32CR3"/>
    <dbReference type="STRING" id="300267.SDY_2855"/>
    <dbReference type="EnsemblBacteria" id="ABB62892">
        <property type="protein sequence ID" value="ABB62892"/>
        <property type="gene ID" value="SDY_2855"/>
    </dbReference>
    <dbReference type="GeneID" id="60903599"/>
    <dbReference type="KEGG" id="sdy:SDY_2855"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3430"/>
    <dbReference type="HOGENOM" id="CLU_125377_0_0_6"/>
    <dbReference type="OMA" id="AQYHDVV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="149" mass="16063" checksum="DEC6BAF7707DFAE1" modified="2005-12-06" version="1">MGLFNFVKDAGEKLWDAVTGQHDKDDQAKKVQEHLNKTGIPDADKVNIQIADGKATVTGDGLSQEAKEKILVAVGNISGIASVDDQVKTATPATASQFYTVKSGDTLSAISKQVYGNANLYNKIFEANKPMLKSPDKIYPGQVLRIPEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CU0</accession>
    <name>GRCA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Autonomous glycyl radical cofactor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">grcA</name>
        <name type="ordered locus">SDY_2822</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a radical domain for damaged PFL and possibly other radical proteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000627803.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404356.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CU0"/>
    <dbReference type="SMR" id="Q32CU0"/>
    <dbReference type="STRING" id="300267.SDY_2822"/>
    <dbReference type="EnsemblBacteria" id="ABB62865">
        <property type="protein sequence ID" value="ABB62865"/>
        <property type="gene ID" value="SDY_2822"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2822"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3399"/>
    <dbReference type="HOGENOM" id="CLU_133780_0_0_6"/>
    <dbReference type="OMA" id="LGQFEYR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00806">
        <property type="entry name" value="GrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011140">
        <property type="entry name" value="Glycyl_radical_cofactor_GrcA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000378">
        <property type="entry name" value="Gly_radicl_yfiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04365">
        <property type="entry name" value="spare_glycyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0556">Organic radical</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000083735" description="Autonomous glycyl radical cofactor">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00806"/>
        </source>
    </evidence>
    <sequence length="127" mass="14326" checksum="548408C78E758CDC" modified="2005-12-06" version="1">MITGIQITKAANDDLLNSFWLLDSEKDEARCIVAKAGFAEDEVVAVSKLGDIEYREVPVEVKPEVRVEGGQHLNVNVLRRETLEDAVKHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D81</accession>
    <name>Q32D81_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydrogenase 4 membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hyfE</name>
        <name evidence="7" type="ordered locus">SDY_2674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000148000.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404215.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D81"/>
    <dbReference type="STRING" id="300267.SDY_2674"/>
    <dbReference type="EnsemblBacteria" id="ABB62724">
        <property type="protein sequence ID" value="ABB62724"/>
        <property type="gene ID" value="SDY_2674"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2674"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3226"/>
    <dbReference type="HOGENOM" id="CLU_088957_2_0_6"/>
    <dbReference type="OMA" id="VFGYCLM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038730">
        <property type="entry name" value="HyfE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38601">
        <property type="entry name" value="PTHR38601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="216" mass="23379" checksum="DDC44099A62B518A" modified="2005-12-06" version="1">MTGSMIVNNLAGLMMLTSLFVISVKSYRLSCGFYACQSLVLVSIFATLSCLFTAEQLLIWSSSAFITKVLLVPLIMTYAARNIPQNIPEKALFGPAMMALLAALIVLLCAFVAQPVKLPMATGLKPALAVALGHFLLGLLCIVSQRNILRQIFGYCLMENGSHLVLALLAWRAPELVEIGIATDAIFAVIVMVLLARKIWRTHGTLDVNNLTALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DA5</accession>
    <name>Q32DA5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001270535.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404191.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DA5"/>
    <dbReference type="STRING" id="300267.SDY_2649"/>
    <dbReference type="EnsemblBacteria" id="ABB62700">
        <property type="protein sequence ID" value="ABB62700"/>
        <property type="gene ID" value="SDY_2649"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2649"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3194"/>
    <dbReference type="HOGENOM" id="CLU_043396_2_0_6"/>
    <dbReference type="OMA" id="ETAWVGK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009560">
        <property type="entry name" value="DUF1176"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06674">
        <property type="entry name" value="DUF1176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221053" evidence="1">
        <location>
            <begin position="22"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="355" mass="39792" checksum="1DC480CE0A31F2D4" modified="2005-12-06" version="1">MRYRIFLLFFFALLPTSLVWAAPAQRAFSDWQVTCNNQNFCVARNTGDHNGLVMTLSRSAGAHTDAVLRIERGGLKSPDASEGEIAPRLLLDGEPLALSGDKWRISPWLLVTDDTATITEFLQMIHEGKAITLRDGNQTISLSGLKAALLFIDAQQKRVGSETAWIKKGDEPLLSVPPAPALKEVAVVNPTPTPLSLEERNDLLDYGNWRMNGLRCSLDPLRREVNVTALTDDKALMMISCEAGAYNTIDLAWIVSRKKPLASRPVRLRLPFNNGQETNELELMNATFDEKSRELVTLAKGRGLSDCGIQARWRFDGQRFRLVRYAAEPTCDNWHGPDAWPTLWITRYTISQMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DD9</accession>
    <name>Q32DD9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Cysteine synthase</fullName>
            <ecNumber evidence="5 11">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysK</name>
        <name evidence="13" type="ordered locus">SDY_2611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 11"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000034409.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404157.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DD9"/>
    <dbReference type="STRING" id="300267.SDY_2611"/>
    <dbReference type="EnsemblBacteria" id="ABB62666">
        <property type="protein sequence ID" value="ABB62666"/>
        <property type="gene ID" value="SDY_2611"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2611"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3148"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_2_6"/>
    <dbReference type="OMA" id="FWDSGER"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="10"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="177"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB62666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="323" mass="34432" checksum="314FCCBEC847535C" modified="2005-12-06" version="1">MSKIFEDNSLTIGHTPLVRLNRIGNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASNPEKYLLLQQFSNPANPEIHEKTTGPEIWEGTDGQVDVFIAGVGTGGTLTGVSRYIKGTKGKTDLISVAVEPTDSPVIAQALAGEEIKPGPHKIQGIGAGFIPANLDLKLVDKVIGITNEEAISTARRLMEEEGILAGISSGAAVAAALKLQEDESFTNKNIVVILPSSGERYLSTALFADLFTEKELQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DF8</accession>
    <name>Q32DF8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative PTS system enzyme IIB component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_2586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000038458.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404138.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DF8"/>
    <dbReference type="STRING" id="300267.SDY_2586"/>
    <dbReference type="EnsemblBacteria" id="ABB62647">
        <property type="protein sequence ID" value="ABB62647"/>
        <property type="gene ID" value="SDY_2586"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2586"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3120"/>
    <dbReference type="HOGENOM" id="CLU_013155_2_1_6"/>
    <dbReference type="OMA" id="IAVCACP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220913" evidence="4">
        <location>
            <begin position="25"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="5">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="108" mass="11763" checksum="FDCAEFA520FB72A9" modified="2005-12-06" version="1">MSKKLIALCACPMGLAHTFMAAQALEEAAVEAGYEVKIETQGADGIQNRLTVQDIAEATIIIHSVAVTPEDNERFESRDVYEITLQDAIKNAAGIIKEIEEMIASEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DM4</accession>
    <name>Q32DM4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">purF</name>
        <name evidence="10" type="ordered locus">SDY_2511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000334214.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404072.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DM4"/>
    <dbReference type="STRING" id="300267.SDY_2511"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="ABB62581">
        <property type="protein sequence ID" value="ABB62581"/>
        <property type="gene ID" value="SDY_2511"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2511"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3026"/>
    <dbReference type="HOGENOM" id="CLU_022389_2_1_6"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="505" mass="56499" checksum="560BCB0A6A15C2A8" modified="2005-12-06" version="1">MCGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFIRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMPGQQLRRKSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVNQGYLDFLDTLRNDDAKAVQRQNEVENLEMHNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DN5</accession>
    <name>Q32DN5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-erythro-7,8-dihydroneopterin tri P epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folX</name>
        <name evidence="3" type="ordered locus">SDY_2500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homooctamer.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000068457.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404061.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DN5"/>
    <dbReference type="SMR" id="Q32DN5"/>
    <dbReference type="STRING" id="300267.SDY_2500"/>
    <dbReference type="EnsemblBacteria" id="ABB62570">
        <property type="protein sequence ID" value="ABB62570"/>
        <property type="gene ID" value="SDY_2500"/>
    </dbReference>
    <dbReference type="GeneID" id="66673814"/>
    <dbReference type="KEGG" id="sdy:SDY_2500"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3012"/>
    <dbReference type="HOGENOM" id="CLU_112632_0_0_6"/>
    <dbReference type="OMA" id="DHALNYR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006760">
        <property type="term" value="P:folic acid-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="120" mass="14082" checksum="5DDFF76540827ED6" modified="2005-12-06" version="1">MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTVTKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DQ0</accession>
    <name>Q32DQ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lrhA</name>
        <name evidence="3" type="ordered locus">SDY_2485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000622272.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404046.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DQ0"/>
    <dbReference type="STRING" id="300267.SDY_2485"/>
    <dbReference type="EnsemblBacteria" id="ABB62555">
        <property type="protein sequence ID" value="ABB62555"/>
        <property type="gene ID" value="SDY_2485"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2485"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2996"/>
    <dbReference type="HOGENOM" id="CLU_039613_1_3_6"/>
    <dbReference type="OMA" id="RTWRITC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="312" mass="34616" checksum="63DBD81ED66BE6E0" modified="2005-12-06" version="1">MISANRPIINLDLDLLRTFVAVADLNTFAAAAAAVCRTQSAVSQQMQRLEQLVGKELFARHGRNKLLTEHGIQLLGYARKILRFNDEACLSLMFSNLQGVLTIGASDESADTILPFLLNRVSSVYPKLALDVRVKRNAYMAEMLESQEVDLMVTTHRPSAFKALNLRTSPTHWYCAAEYVLRKGEPIPLVLLDDPSPFRDMVLATLNKADIPWRLAYVASTLPAVRAAVKAGLGVTARPVEMMSPDLRVLSGVDGLPPLPDTEYLLCYDPSSNNELAQVIYQAMESYHNPWQYSPISAPEGDDSLLIERDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DR5</accession>
    <name>Q32DR5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DR5"/>
    <dbReference type="STRING" id="300267.SDY_2470"/>
    <dbReference type="EnsemblBacteria" id="ABB62540">
        <property type="protein sequence ID" value="ABB62540"/>
        <property type="gene ID" value="SDY_2470"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2470"/>
    <dbReference type="HOGENOM" id="CLU_048743_2_1_6"/>
    <dbReference type="OMA" id="GKMQDIN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="94" mass="10746" checksum="46FB731000903181" modified="2005-12-06" version="1">MEASPNAVRQVKAALLSSRDLSVYSMNAPCFIHGIDFSYHLNYWQHDIPAVMITDTAFYRNKQYHLPGDTADRLNYQKMAQMVDGVITLLHNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DW4</accession>
    <name>Q32DW4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403982.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DW4"/>
    <dbReference type="STRING" id="300267.SDY_2418"/>
    <dbReference type="EnsemblBacteria" id="ABB62491">
        <property type="protein sequence ID" value="ABB62491"/>
        <property type="gene ID" value="SDY_2418"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2418"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2916"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="TEIAYNI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="262" mass="30533" checksum="9E1F16C9A7CF311F" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSVMRMGETKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E13</accession>
    <name>Q32E13_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anaerobic dimethyl sulfoxide reductase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dmsA</name>
        <name evidence="10" type="ordered locus">SDY_2367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403933.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E13"/>
    <dbReference type="STRING" id="300267.SDY_2367"/>
    <dbReference type="EnsemblBacteria" id="ABB62442">
        <property type="protein sequence ID" value="ABB62442"/>
        <property type="gene ID" value="SDY_2367"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2367"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2860"/>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_6"/>
    <dbReference type="OMA" id="CPLDCPD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009389">
        <property type="term" value="F:dimethyl sulfoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011888">
        <property type="entry name" value="Anaer_DMSO_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02166">
        <property type="entry name" value="dmsA_ynfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="785" mass="87451" checksum="B36337826297F3B0" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-11-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EA9</accession>
    <name>GATY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-tagatose-1,6-bisphosphate aldolase subunit GatY</fullName>
            <shortName evidence="1">TBPA</shortName>
            <shortName evidence="1">TagBP aldolase</shortName>
            <ecNumber evidence="1">4.1.2.40</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-tagatose-bisphosphate aldolase class II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tagatose-bisphosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatY</name>
        <name type="ordered locus">SDY_2269</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:22948"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58694"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with GatZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase GatY subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62346" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="4.1.2.40" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62346.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021752.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403837.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EA9"/>
    <dbReference type="SMR" id="Q32EA9"/>
    <dbReference type="STRING" id="300267.SDY_2269"/>
    <dbReference type="EnsemblBacteria" id="ABB62346">
        <property type="protein sequence ID" value="ABB62346"/>
        <property type="gene ID" value="SDY_2269"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2269"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2742"/>
    <dbReference type="HOGENOM" id="CLU_040088_0_1_6"/>
    <dbReference type="UniPathway" id="UPA00704">
        <property type="reaction ID" value="UER00716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009025">
        <property type="term" value="F:tagatose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001059">
        <property type="term" value="P:D-tagatose 6-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019404">
        <property type="term" value="P:galactitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01294">
        <property type="entry name" value="TagBP_aldolase_GatY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011288">
        <property type="entry name" value="TagBP_ald_KbaY/GatY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023955">
        <property type="entry name" value="TagBP_aldolase_GatY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01858">
        <property type="entry name" value="tag_bisphos_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0298">Galactitol metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000355354" description="D-tagatose-1,6-bisphosphate aldolase subunit GatY">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="284" mass="30884" checksum="101B82DE52F469A8" modified="2008-11-25" version="2">MYVVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAANLHAPVIIAGTPGTFTHAGIENLLALVSAMAKQYHHLLAIHLDHHTKFDDIAQKVRSGVRSVMIDASHLPFAQNISRVKEVVDFCHRFDVSVEAELGQLGGQEDDVQVNEADALYTNPVQAREFAEATGIDSLAVAIGTAHGMYASAPALDFSRLENIRQWVNLPLVLHGASGLSTKDIQQTIKLGICKINVATELKNSFSQALKNYLTEHPEATDPRDYLQSAKSAMRDVVSKVIADCGCEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EG0</accession>
    <name>Q32EG0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rhamnosyl transferase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rfbR</name>
        <name evidence="1" type="ordered locus">SDY_2210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001045977.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403786.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EG0"/>
    <dbReference type="STRING" id="300267.SDY_2210"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62295">
        <property type="protein sequence ID" value="ABB62295"/>
        <property type="gene ID" value="SDY_2210"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2210"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2673"/>
    <dbReference type="HOGENOM" id="CLU_023845_9_1_6"/>
    <dbReference type="OMA" id="SANKHAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="282" mass="32827" checksum="ADFA4A1FC550FF53" modified="2005-12-06" version="1">MNKYCILVLFNPDISVFIDNVKKILSLDVSLFVYDNSANKHAFLALSSQEQTKINYFSICENIGLSKAYNETLRHILEFNKNVKNKSINDSVLFLDQDSEVDLNSINILFETISAAESNVMIVAGNPIRRDGLPYIDYPHTVNNVKFVISSYAVYRLDAFRNIGLFQEDFFIDHIDSDFCSRLIKSNYQILLRKDAFFYQPIGIKPFNLCGRYLFPIPSQHRTYFQIRNAFLSYRRNGVTFNFLFREIVNRLIMSIFSGLNEKDLLKRLHLYLKGIKDGLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EJ2</accession>
    <name>Q32EJ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">molR_D</name>
        <name evidence="2" type="ordered locus">SDY_2177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EJ2"/>
    <dbReference type="STRING" id="300267.SDY_2177"/>
    <dbReference type="EnsemblBacteria" id="ABB62263">
        <property type="protein sequence ID" value="ABB62263"/>
        <property type="gene ID" value="SDY_2177"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2177"/>
    <dbReference type="HOGENOM" id="CLU_006807_3_1_6"/>
    <dbReference type="OMA" id="RENARTW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025406">
        <property type="entry name" value="DUF4132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13569">
        <property type="entry name" value="DUF4132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4132" evidence="1">
        <location>
            <begin position="176"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="452" mass="50318" checksum="97AEB81D949A4080" modified="2005-12-06" version="1">MLRFPQEEALYPGLLQVKDACTADSLAEFAWDLFTAWLTAGAPSKESWAFTALGVLGNDDTARKLTPLIRAWPGESQHKRATVGLDILAAIGSDIALMQLNGIAQKLKFKALQERAKEKIADIAESRELTVAEFEDRLAPDLGLDDNGSLLLDFSSRQFTVSFDETLKPFVRDVSGSRLKDLPKPNKSDDESQANDAVNRYKLLKKDARTVAAQQVARLESAMCLRRRWSPENFQLFLVEHPLVRHLTRRLIWGVYSAENQLQACFRVAEDNSYSTADDDLFTLPEGDISIGIPHVLEISPTDAAAFGQLFADYELLPPFRQLDRNSYALTEAERNASELTRWAGRKCPSGRVMGLANKGWIKGEPQDGGWIGWMIKPLGCWSLIMEIDEGFAVGMSPAELSAEQLLSKLWLWEGKAESYGWGSNSTQEAKLSVLDTITASELINDIEALFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EK6</accession>
    <name>Q32EK6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">yehU</name>
        <name evidence="14" type="ordered locus">SDY_2163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021819.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403740.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EK6"/>
    <dbReference type="STRING" id="300267.SDY_2163"/>
    <dbReference type="EnsemblBacteria" id="ABB62249">
        <property type="protein sequence ID" value="ABB62249"/>
        <property type="gene ID" value="SDY_2163"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2163"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2615"/>
    <dbReference type="HOGENOM" id="CLU_020473_3_3_6"/>
    <dbReference type="OMA" id="SHFFRSN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011620">
        <property type="entry name" value="Sig_transdc_His_kinase_LytS_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07694">
        <property type="entry name" value="5TM-5TMR_LYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="13">
        <location>
            <begin position="218"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB62249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="561" mass="62136" checksum="0401A3948C290230" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EM1</accession>
    <name>YOHJ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0299 membrane protein YohJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yohJ</name>
        <name type="ordered locus">SDY_2146</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0299 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021862.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403725.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EM1"/>
    <dbReference type="SMR" id="Q32EM1"/>
    <dbReference type="STRING" id="300267.SDY_2146"/>
    <dbReference type="EnsemblBacteria" id="ABB62234">
        <property type="protein sequence ID" value="ABB62234"/>
        <property type="gene ID" value="SDY_2146"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2146"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2593"/>
    <dbReference type="HOGENOM" id="CLU_113736_1_1_6"/>
    <dbReference type="OMA" id="MSVMFIP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01144">
        <property type="entry name" value="UPF0299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005538">
        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022957">
        <property type="entry name" value="Uncharacterised_UPF0299"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33931">
        <property type="entry name" value="PTHR33931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03788">
        <property type="entry name" value="LrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000065466" description="UPF0299 membrane protein YohJ">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01144"/>
        </source>
    </evidence>
    <sequence length="132" mass="14625" checksum="ADADA3254DFE9E49" modified="2005-12-06" version="1">MSKTLNIIWQYLRAFVLIYACLYAGIFIASLLPVTIPGSIIGMLILFVLLALQILPAKWVNPGCYVLIRYMALLFVPIGVGVMQYFDLLRAQFGPVVVSCAISTLVVFLVMSWSSQLVHGERKVVGQKGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EP7</accession>
    <name>Q32EP7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EP7"/>
    <dbReference type="EnsemblBacteria" id="ABB62208">
        <property type="protein sequence ID" value="ABB62208"/>
        <property type="gene ID" value="SDY_2118"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2118"/>
    <dbReference type="HOGENOM" id="CLU_138379_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="8814" checksum="0CAE846FC2103E49" modified="2005-12-06" version="1">MNNVFLYRMPVGIAGAVSRPQDLTVEPVVLKSDNAFAAYGLAGKYDDDGFFVPLADGDTADKVKGIYVRPYPTTSQPDMVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ES9</accession>
    <name>YCEH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0502 protein YceH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yceH</name>
        <name type="ordered locus">SDY_2085</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0502 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000877086.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403667.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ES9"/>
    <dbReference type="SMR" id="Q32ES9"/>
    <dbReference type="STRING" id="300267.SDY_2085"/>
    <dbReference type="PRIDE" id="Q32ES9"/>
    <dbReference type="EnsemblBacteria" id="ABB62176">
        <property type="protein sequence ID" value="ABB62176"/>
        <property type="gene ID" value="SDY_2085"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2085"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2507"/>
    <dbReference type="HOGENOM" id="CLU_057831_2_0_6"/>
    <dbReference type="OMA" id="CNQKSSR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01584">
        <property type="entry name" value="UPF0502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007432">
        <property type="entry name" value="DUF480"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38768">
        <property type="entry name" value="PTHR38768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04337">
        <property type="entry name" value="DUF480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000309433" description="UPF0502 protein YceH">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01584"/>
        </source>
    </evidence>
    <sequence length="215" mass="24164" checksum="279C3C0D001DBB5B" modified="2005-12-06" version="1">MKYQLTALEARVIGCLLEKQVTTPEQYPLSANGVVTACNQKMNREPVMNLSESEVQEQLDNLVKRHYLRTVSGFGNRGTKYEQRFCNSEFGDLKLSAAEVALITTLLLRGAQTSGELRSRAARMYEFRDMAEVESTLEQLANREDGPFVVRLAREPGKRESRYMHLFSGEVEDPPAVTDMLNAVDGDLQARVEALEIEVAELKQRLDSLLAHLGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EU0</accession>
    <name>FLGI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellar P-ring protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Basal body P-ring protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">flgI</name>
        <name type="ordered locus">SDY_2071</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022057.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403656.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EU0"/>
    <dbReference type="SMR" id="Q32EU0"/>
    <dbReference type="STRING" id="300267.SDY_2071"/>
    <dbReference type="EnsemblBacteria" id="ABB62165">
        <property type="protein sequence ID" value="ABB62165"/>
        <property type="gene ID" value="SDY_2071"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2071"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2487"/>
    <dbReference type="HOGENOM" id="CLU_045235_1_0_6"/>
    <dbReference type="OMA" id="KTIQITR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009428">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, P ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00416">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001782">
        <property type="entry name" value="Flag_FlgI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30381">
        <property type="entry name" value="PTHR30381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02119">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01010">
        <property type="entry name" value="FLGPRINGFLGI"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000236319" description="Flagellar P-ring protein">
        <location>
            <begin position="20"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00416"/>
        </source>
    </evidence>
    <sequence length="365" mass="38214" checksum="D6DB3CDA7713F784" modified="2005-12-06" version="1" precursor="true">MIKFLSALILLLVTTAAQAERIRDLTSVQGVRQNSLIGYGLVVGLDGTGDQTTQTPFTTQTLNNMLSQLGITVPTGTNMQLKNVAAVMVTASLPPFGRQGQTIDVVVSSMGNAKSLRGGTLLMTPLKGVDSQVYALAQGNILVGGAGASAGGSSVQVNQLNGGRITNGAVIERELPSQFGVGNTLNLQLNDEDFSMAQQIADTINRVRGYGSATVLDARTIQVRVPSGNSSQVRFLADIQNMQVNVTPQDAKVVINSRTGSVVMNREVTLDSCAVAQGNLSVTVNRQANVSQPDTPFGGGQTVVTPQTQIDLRQSGGSLQSVRSSASLNNVVRSLNALGATPMDLMSILQSMQSAGCLRAKLEII</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-08" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EV0</accession>
    <name>PLSX_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsX</name>
        <name type="ordered locus">SDY_2060</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PlsX family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62155" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62155.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000197594.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403646.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EV0"/>
    <dbReference type="SMR" id="Q32EV0"/>
    <dbReference type="STRING" id="300267.SDY_2060"/>
    <dbReference type="EnsemblBacteria" id="ABB62155">
        <property type="protein sequence ID" value="ABB62155"/>
        <property type="gene ID" value="SDY_2060"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2060"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2475"/>
    <dbReference type="HOGENOM" id="CLU_039379_1_0_6"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000329264" description="Phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="356" mass="38196" checksum="D67A0B4E9EBC22F3" modified="2008-04-08" version="2">MTRLTLALDVMGGDFGPSVTVPAALQALNSNSQLTLLLVGNPDAITPLLAKADSEQRSRLQIIPAQSVIASDARPSQAIRASRGSSMRMALELVKEGRAQACVSAGNTGALMGLAKLLLKPLEGIERPALVTVLPHQQKGKTVVLDLGANVDCDSTMLVQFAIMGSVLAEEVVEIPNPRVALLNIGEEEVKGLDSIRDASAVLKTIPSINYIGYLEANELLTGKTDVLVCDGFTGNVTLKTMEGVVRMFLSLLKSQGEGKKRSWWLLLLKRWLQKSLTRRFSHLNPDQYNGACLLGLRGTVIKSHGAANQRAFAVAIEQAVQAVQRQVPQRIAARLESVYPAGFELLDGGKSGTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EX8</accession>
    <name>Q32EX8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ycfW</name>
        <name evidence="11" type="ordered locus">SDY_2032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001251370.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403618.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EX8"/>
    <dbReference type="STRING" id="300267.SDY_2032"/>
    <dbReference type="EnsemblBacteria" id="ABB62127">
        <property type="protein sequence ID" value="ABB62127"/>
        <property type="gene ID" value="SDY_2032"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2032"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2445"/>
    <dbReference type="HOGENOM" id="CLU_000604_8_1_6"/>
    <dbReference type="OMA" id="ERTQMIG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044874">
        <property type="term" value="P:lipoprotein localization to outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011925">
        <property type="entry name" value="LolCE_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011926">
        <property type="entry name" value="LolE_gammaproteobact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02212">
        <property type="entry name" value="lolCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02213">
        <property type="entry name" value="lolE_release"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="27"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="300"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="414" mass="45380" checksum="262D6A5E436185F3" modified="2005-12-06" version="1">MAMPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRILAVVPHGEIEAVDQPWTNWQEALDNVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVNPQQEQRLSALSSFVQGDAWRNFKAGEQQIIIGKGVADALKVKQGDWVSIMIPNSNPEHKLMQPKRVRLHVAGILQLSGQLDHSFAMIPLADAQQYLDMGSSVSGIALKMTDVFNANKLVRDAGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMVLVIGVACFNIVSTLVMAVKDKSRDIAVLRTLGAKDGLIRAIFVWYGLLAGLFGSLCGVIIGVVVSLQLTPIIERIEKLIGHQFLSSDIYFIDFLPSELHWLDVFYVLVTALLLSLLASWYPARRASNIDPARVLSGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FI3</accession>
    <name>RL20_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplT</name>
        <name type="ordered locus">SDY_1811</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000124857.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403413.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FI3"/>
    <dbReference type="SMR" id="Q32FI3"/>
    <dbReference type="STRING" id="300267.SDY_1811"/>
    <dbReference type="EnsemblBacteria" id="ABB61922">
        <property type="protein sequence ID" value="ABB61922"/>
        <property type="gene ID" value="SDY_1811"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1811"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2182"/>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_6"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000243735" description="50S ribosomal protein L20">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <sequence length="118" mass="13527" checksum="FCA05CAA6F05DFB3" modified="2005-12-06" version="1">MARVKRGVIARTRHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVFDKVAFTALVEKAKAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FN7</accession>
    <name>Q32FN7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimL</name>
        <name evidence="2" type="ordered locus">SDY_1751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022514.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403359.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FN7"/>
    <dbReference type="STRING" id="300267.SDY_1751"/>
    <dbReference type="EnsemblBacteria" id="ABB61868">
        <property type="protein sequence ID" value="ABB61868"/>
        <property type="gene ID" value="SDY_1751"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1751"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2111"/>
    <dbReference type="HOGENOM" id="CLU_013985_3_0_6"/>
    <dbReference type="OMA" id="SQWLAWP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="179" mass="20596" checksum="78ABE7DD87CC24CD" modified="2005-12-06" version="1">MTETIKVSESLELHAVAENHVTPLYQLICKNKTWLQLSLNWPQFVQSEEDTRKTVQGNVMLHQRGYAKMFMIFKEDELIGVISFNRIEPLNKTAEIGYWLDESHQGQGSISQALQAPIHHYAQSGELRRFVIKCRVDNPQSNQVALRNGFILEGCLKQAEFLNDAYDDVNLYARIIDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FV1</accession>
    <name>Q32FV1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FV1"/>
    <dbReference type="EnsemblBacteria" id="ABB61804">
        <property type="protein sequence ID" value="ABB61804"/>
        <property type="gene ID" value="SDY_1683"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1683"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="118" mass="13438" checksum="B611548401FAB336" modified="2005-12-06" version="1">MAVKPGYTGSGTRITPKQGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FV5</accession>
    <name>Q32FV5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403291.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FV5"/>
    <dbReference type="EnsemblBacteria" id="ABB61800">
        <property type="protein sequence ID" value="ABB61800"/>
        <property type="gene ID" value="SDY_1679"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1679"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2025"/>
    <dbReference type="HOGENOM" id="CLU_135528_0_0_6"/>
    <dbReference type="OMA" id="YQSVANE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015060">
        <property type="entry name" value="DUF1870"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027910">
        <property type="entry name" value="YdiL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08965">
        <property type="entry name" value="DUF1870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="127" mass="14946" checksum="D8DCDDBE9E7142E4" modified="2005-12-06" version="1">MFISCSHYTMNAYELQALRHIFAMTIDECATWIAQTGDSESWRQWENGKCAIPDCVVEQLLAMRQQRKKHLHAIIEKINNRIGNNTMRFFPDLTAFQRVYPDGNFIDWKIYQSVAAELYAHDLERLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FW1</accession>
    <name>Q32FW1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403285.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FW1"/>
    <dbReference type="STRING" id="300267.SDY_1673"/>
    <dbReference type="EnsemblBacteria" id="ABB61794">
        <property type="protein sequence ID" value="ABB61794"/>
        <property type="gene ID" value="SDY_1673"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1673"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2019"/>
    <dbReference type="HOGENOM" id="CLU_179884_0_0_6"/>
    <dbReference type="OMA" id="WRLGVHV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031830">
        <property type="entry name" value="YdiH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15930">
        <property type="entry name" value="YdiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="89" mass="10464" checksum="FF33CC9F776B9511" modified="2005-12-06" version="1">MTHIAFGHYLHSKRWYTVQVLSKSEDAMSTQLEPPQLAIEFLRRDQSNLSPAQYLKRLKQLELEFADLLTLSSAELKEEIYFAWRLGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FX9</accession>
    <name>Q32FX9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yddE</name>
        <name evidence="3" type="ordered locus">SDY_1654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000804408.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403267.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FX9"/>
    <dbReference type="STRING" id="300267.SDY_1654"/>
    <dbReference type="EnsemblBacteria" id="ABB61776">
        <property type="protein sequence ID" value="ABB61776"/>
        <property type="gene ID" value="SDY_1654"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1654"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1994"/>
    <dbReference type="HOGENOM" id="CLU_048756_0_2_6"/>
    <dbReference type="OMA" id="CHAWLQA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="297" mass="32224" checksum="27CF1127E875EDBA" modified="2005-12-06" version="1">MKPQVYHVDAFTSQPFRGNSAGVVFPADNLSEAQMQLIARELGHSETAFLLHSDDSDVRIRYFTPTVEVPICGHATVAAHYVRAKVLGLGNCTVWQTSLAGKHRVTIEKHHDGYRISLEQGTPGFEPPLEGKTRAAIINTLHLTEDDILPGLPIQVATTGHSKVMIPLKPEVDIDALSPDLAALSAISKQIGCNGFFPFQIRPGKNETDGRMFSPAIGIVEDPVTGNANGPLGAWLVHHNVLPHDGNVLRVKGHQGRALGRDGMIEVTVTIRDNQPEKVTISGTAVILFHAEWAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G32</accession>
    <name>Q32G32_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ydeD</name>
        <name evidence="6" type="ordered locus">SDY_1594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G32"/>
    <dbReference type="STRING" id="300267.SDY_1594"/>
    <dbReference type="EnsemblBacteria" id="ABB61723">
        <property type="protein sequence ID" value="ABB61723"/>
        <property type="gene ID" value="SDY_1594"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1594"/>
    <dbReference type="HOGENOM" id="CLU_033863_20_1_6"/>
    <dbReference type="OMA" id="NTLTWPV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="5">
        <location>
            <begin position="110"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="266" mass="28713" checksum="035DFEB85F81CCF7" modified="2005-12-06" version="1">MLAGLRFMLVAFPAIFFVARPKVPLNLLLGYGLTISFAQFAFLFCAINFGMPAGLASLVLQAQAFFTIVLGAFTFGERLHGKQLAGIALAIFGVVVLIEDSLNGQHVAMLGFMLTLAAAFSWACGNIFNKKIMSHATRPPVMSLVIWSALIPIIPFFVASLILDGSGKMIHSLVTIDMTTILALMYLAFVATIVGYGIWGTLLGRYETWRVAPLSLLVPVVGLASAALLLDERLTGLQFLAAVLIMAGLYINVFGLQWRKAVKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GQ3</accession>
    <name>Q32GQ3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipopolysaccharide assembly protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yciM</name>
        <name evidence="2" type="synonym">lapB</name>
        <name evidence="5" type="ordered locus">SDY_1356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000891360.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402993.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GQ3"/>
    <dbReference type="STRING" id="300267.SDY_1356"/>
    <dbReference type="EnsemblBacteria" id="ABB61502">
        <property type="protein sequence ID" value="ABB61502"/>
        <property type="gene ID" value="SDY_1356"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1356"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1606"/>
    <dbReference type="HOGENOM" id="CLU_059365_1_0_6"/>
    <dbReference type="OMA" id="FWQCPGC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031235">
        <property type="term" value="C:intrinsic component of the cytoplasmic side of the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008653">
        <property type="term" value="P:lipopolysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046890">
        <property type="term" value="P:regulation of lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00994">
        <property type="entry name" value="LPS_assembly_LapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030865">
        <property type="entry name" value="LapB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_2" evidence="4">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="389" mass="44545" checksum="5ADA5AD11EDDAF08" modified="2005-12-06" version="1">MLELLFLLLPVAAAYGWYMGRRSAQQNKQDEANRLSRDYVAGVNFLLSNQQDKAVDLFLDMLKEDTGTVEAHLTLGNLFRSRGEVDRAIRIHQTLMESASLTYEQRLLAIQQLGRDYMAAGLYDRAEDMFNQLTDETDFRIGALQQLLQIYQATSEWQKAIDVAERLVKLGKDKQRVEIAHFYCELALQHMASDDLDRAMTLLKKGAAADNNSARVSIMMGRVFMAKGEYAKAVESLQRVISQDRELVSETLEMLQTCYQQLGKTAEWAEFLQRAVEENTGADAELMLADIIEVRDGSEAAQVYITRQLQRHPTMRVFHKLMDYHLNEAEEGRAKESLMVLRDMVGEKVRSKPRYRCQKCGFTAYTLYWHCPSCRAWSTIKPIRGLDGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GZ6</accession>
    <name>RF1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide chain release factor 1</fullName>
            <shortName evidence="1">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prfA</name>
        <name type="ordered locus">SDY_1260</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000804726.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402900.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GZ6"/>
    <dbReference type="SMR" id="Q32GZ6"/>
    <dbReference type="STRING" id="300267.SDY_1260"/>
    <dbReference type="EnsemblBacteria" id="ABB61409">
        <property type="protein sequence ID" value="ABB61409"/>
        <property type="gene ID" value="SDY_1260"/>
    </dbReference>
    <dbReference type="GeneID" id="66674969"/>
    <dbReference type="KEGG" id="sdy:SDY_1260"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1497"/>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_6"/>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000263352" description="Peptide chain release factor 1">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="360" mass="40517" checksum="47B3B77705A71954" modified="2005-12-06" version="1">MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H40</accession>
    <name>Q32H40_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000284286.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402856.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H40"/>
    <dbReference type="STRING" id="300267.SDY_1212"/>
    <dbReference type="EnsemblBacteria" id="ABB61365">
        <property type="protein sequence ID" value="ABB61365"/>
        <property type="gene ID" value="SDY_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1212"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1438"/>
    <dbReference type="HOGENOM" id="CLU_028458_5_2_6"/>
    <dbReference type="OMA" id="YALSIDM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="23633" checksum="6F21FAD02E0A48F6" modified="2005-12-06" version="1">MYQHHNWQGALLDYPVSKVVCVGSNYAKHIKEMGSAVPEEPVLFIKPETALCDLRQPLAIPSDFGSVHHEVELAVLIGATLRQATEEHVRKAIAGYGVALDLTLRDVQGKMKKAGQPWEKAKAFDNSCPLSGVIPAAEFTGDPQNTTLGLSVNGEQRQQGTTADMIHKIVPLIAYMSKFFTLKAGDVVLTGTPDGVGPLQSGDELTVTFDGHSLTTRVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HA0</accession>
    <name>RUVA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvA</name>
        <name type="ordered locus">SDY_1148</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000580325.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402796.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HA0"/>
    <dbReference type="SMR" id="Q32HA0"/>
    <dbReference type="STRING" id="300267.SDY_1148"/>
    <dbReference type="EnsemblBacteria" id="ABB61305">
        <property type="protein sequence ID" value="ABB61305"/>
        <property type="gene ID" value="SDY_1148"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1148"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1351"/>
    <dbReference type="HOGENOM" id="CLU_087936_0_0_6"/>
    <dbReference type="OMA" id="VGMAVQC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000224907" description="Holliday junction ATP-dependent DNA helicase RuvA">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <sequence length="203" mass="22114" checksum="805DDB79DC5A910E" modified="2005-12-06" version="1">MIGRLRGIIIEKQPPLVLIEVGGVGYEVHMPMTCFYELPEAGQEAIVFTHFVVREDAQLLYGFNNKQERTLFKELIKTNGVGPKLALAILSGMSAQQFVNAVEREEVGALVKLPGIGKKTAERLIVEMKDRFKGLHGDLFTPAADLVLTSPASPATDDAEQEAVAALVALGYKPQEASRMVSKIARPDVSSETLIREALRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HF7</accession>
    <name>Q32HF7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0033 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yedF</name>
        <name evidence="3" type="ordered locus">SDY_1085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000790504.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402739.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HF7"/>
    <dbReference type="SMR" id="Q32HF7"/>
    <dbReference type="STRING" id="300267.SDY_1085"/>
    <dbReference type="EnsemblBacteria" id="ABB61248">
        <property type="protein sequence ID" value="ABB61248"/>
        <property type="gene ID" value="SDY_1085"/>
    </dbReference>
    <dbReference type="GeneID" id="64169660"/>
    <dbReference type="GeneID" id="67513677"/>
    <dbReference type="KEGG" id="sdy:SDY_1085"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1275"/>
    <dbReference type="HOGENOM" id="CLU_165255_0_0_6"/>
    <dbReference type="OMA" id="VCPYPQL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="77" mass="8639" checksum="40E393E76CC54AB0" modified="2005-12-06" version="1">MKNIVPDYRLDMVGEPCPYPAVATLEAMPQLKKGEILEVVSDCPQSINNIPLDARNHGYTVLDIQQDGPTIRYLIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HT6</accession>
    <name>Q32HT6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative carrier/transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yccA</name>
        <name evidence="7" type="ordered locus">SDY_0945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000375136.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402610.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HT6"/>
    <dbReference type="SMR" id="Q32HT6"/>
    <dbReference type="STRING" id="300267.SDY_0945"/>
    <dbReference type="EnsemblBacteria" id="ABB61119">
        <property type="protein sequence ID" value="ABB61119"/>
        <property type="gene ID" value="SDY_0945"/>
    </dbReference>
    <dbReference type="GeneID" id="67414142"/>
    <dbReference type="KEGG" id="sdy:SDY_0945"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1093"/>
    <dbReference type="HOGENOM" id="CLU_058671_2_1_6"/>
    <dbReference type="OMA" id="MGDVIGM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006213">
        <property type="entry name" value="Bax_inhbtr1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="PTHR23291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01243">
        <property type="entry name" value="BI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="23363" checksum="4F787B853042ACD8" modified="2005-12-06" version="1">MDRIVSSSHDRTSLLSTHKVLRNTYFLLSLTLAFSAITATASTVLMLPSPGLILTLVGMYGLMFLTYKTANKPTGIISAFAFTGFLGYILGPILNTYLSAGMGDVIAMALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVFILISSGAILFETSNIIHGGETNYIRATVSLYVSLYNIFVSLLSILGFASRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I22</accession>
    <name>Q32I22_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2135 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I22"/>
    <dbReference type="STRING" id="300267.SDY_0855"/>
    <dbReference type="EnsemblBacteria" id="ABB61033">
        <property type="protein sequence ID" value="ABB61033"/>
        <property type="gene ID" value="SDY_0855"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0855"/>
    <dbReference type="HOGENOM" id="CLU_2510865_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019220">
        <property type="entry name" value="DUF2135"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09906">
        <property type="entry name" value="DUF2135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2135" evidence="1">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="85" mass="9480" checksum="90DC6C410623FB26" modified="2005-12-06" version="1">MLKNSGALDMDVTTGYGPEIFAMPAPVHGRYQVYINYYGGRSETELTTAQLTLITDEGSVNEKQETFIVPMRNAGELTLVKSFDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I33</accession>
    <name>Q32I33_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional repressor for deo operon, tsx, nupG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">deoR</name>
        <name evidence="5" type="ordered locus">SDY_0842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000450127.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402513.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I33"/>
    <dbReference type="STRING" id="300267.SDY_0842"/>
    <dbReference type="EnsemblBacteria" id="ABB61024">
        <property type="protein sequence ID" value="ABB61024"/>
        <property type="gene ID" value="SDY_0842"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0842"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.969"/>
    <dbReference type="HOGENOM" id="CLU_060699_4_0_6"/>
    <dbReference type="OMA" id="CFHFHEV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="252" mass="28613" checksum="69CD13EC97191FA3" modified="2005-12-06" version="1">METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKRRAAKLAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAVCYSLNTFLALKEKPHCRAFLCGGEFHASNTIFKPIDFQQTLNNFCPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMLMAQKHVLVVDHSKFGKVRPARMGDLKRFDIVVSDCCPEDEYVKYAQTHRIKLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I93</accession>
    <name>Q32I93_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ybiP</name>
        <name evidence="8" type="ordered locus">SDY_0780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001054682.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402453.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I93"/>
    <dbReference type="STRING" id="300267.SDY_0780"/>
    <dbReference type="EnsemblBacteria" id="ABB60964">
        <property type="protein sequence ID" value="ABB60964"/>
        <property type="gene ID" value="SDY_0780"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0780"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.899"/>
    <dbReference type="HOGENOM" id="CLU_039390_3_0_6"/>
    <dbReference type="OMA" id="EVQYLAH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040423">
        <property type="entry name" value="PEA_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30443">
        <property type="entry name" value="PTHR30443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="7">
        <location>
            <begin position="217"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="527" mass="59764" checksum="646ACDAF0BF98BED" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IB2</accession>
    <name>Q32IB2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">moeB</name>
        <name evidence="2" type="ordered locus">SDY_0761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000829230.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402434.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IB2"/>
    <dbReference type="STRING" id="300267.SDY_0761"/>
    <dbReference type="EnsemblBacteria" id="ABB60945">
        <property type="protein sequence ID" value="ABB60945"/>
        <property type="gene ID" value="SDY_0761"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0761"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.875"/>
    <dbReference type="HOGENOM" id="CLU_013325_10_3_6"/>
    <dbReference type="OMA" id="MIYDALE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012730">
        <property type="entry name" value="Mopterin_Synthase_Sase_MoeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02355">
        <property type="entry name" value="moeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="12"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="249" mass="26613" checksum="6C1242894B3CBD8A" modified="2005-12-06" version="1">MAELSDQEMLRYNRQIILRGFDFDGQEALKDSRVLVVGLGGLGCAASQYLASAGVGNLTLLDFDSVSLSNLQRQTLHSDATVGQPKVESARDALARINPHIAITPVNALLDDAELAALIAEHDLVLDCTDNVAVRNQLNAGCFAAKVPLVSGAAIRMEGQITVFTYQDGEPCYRCLSRLFGENALTCVEAGVMAPLIGVIGSLQAMEAIKLLAGYGKPASGKIVMYDAMTCQFREMKLTRNPGCEVCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IK7</accession>
    <name>Q32IK7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate dehydrogenase iron-sulfur subunit</fullName>
            <ecNumber evidence="7">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sdhB</name>
        <name evidence="10" type="ordered locus">SDY_0662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="7">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001235253.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402339.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IK7"/>
    <dbReference type="STRING" id="300267.SDY_0662"/>
    <dbReference type="EnsemblBacteria" id="ABB60850">
        <property type="protein sequence ID" value="ABB60850"/>
        <property type="gene ID" value="SDY_0662"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0662"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.773"/>
    <dbReference type="HOGENOM" id="CLU_044838_0_2_6"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
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        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6 7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="238" mass="26842" checksum="026EEEFE32EC1834" modified="2005-12-06" version="1">MRLEFSIYRYNPDVDDAPRMQDYTLEADEGRDMMLLDALIQLKEKDPSLSFRRSCREGVCGSDGLNMNGKNGLACITPISALNQPGKKIVIRPLPGLPVIRDLVVDMGQFYAQYEKIKPYLLNNEQNPPAREHLQMPEQREKLDGLYECILCACCSTSCPSFWWNPDKFIGPAGLLAAYRFLIDSRDTETDSRLDGLSDAFSVFRCHSIMNCVSVCPKGLNPTRAIGHIKSMLLQRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IZ4</accession>
    <name>Q32IZ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_0506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000621916.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402202.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IZ4"/>
    <dbReference type="STRING" id="300267.SDY_0506"/>
    <dbReference type="EnsemblBacteria" id="ABB60713">
        <property type="protein sequence ID" value="ABB60713"/>
        <property type="gene ID" value="SDY_0506"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0506"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.597"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_6"/>
    <dbReference type="OMA" id="DDPMMQL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="209" mass="22840" checksum="7B17C4C4ADB55A4E" modified="2005-12-06" version="1">MIRVVLVDDHVVVRSGFAQLLSLEDDLEVIGQYSSAAQAWSALIRDDVNVAVIDIAMPDENGLSLLKRLRAQKPQFRAIILSIYDAPTFVQSALDAGASGYLTKRCGPEELVQAVRSVGLGGHYLCADAIRALRGGGQPAQALEILTPREREVFDLLVKGDSVKEIAFKLELSHKTVHVHRANVLGKLNCHSTIELVHFVLDHHLLAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J11</accession>
    <name>Q32J11_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phenylalanine-specific transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pheP</name>
        <name evidence="8" type="ordered locus">SDY_0489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000786304.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402185.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J11"/>
    <dbReference type="STRING" id="300267.SDY_0489"/>
    <dbReference type="EnsemblBacteria" id="ABB60696">
        <property type="protein sequence ID" value="ABB60696"/>
        <property type="gene ID" value="SDY_0489"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0489"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.578"/>
    <dbReference type="HOGENOM" id="CLU_007946_9_3_6"/>
    <dbReference type="OMA" id="MFAYLAV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="27"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="458" mass="50767" checksum="F891781F2F399EDE" modified="2005-12-06" version="1">MKNASTVSEDTASNQEPTLHRGLHNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGIIAFLIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINAVNLVNVRLYGETEFWFALIKVLAIIGMIGFGLWLLFFGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELIGITAAEARDPEKSIPKAVNQVVYRILLFYIGSLVVLLAFYPWVEVKSNSSPFVMIFHNLDSNVVASALNFVILVVSLSVYNSGVYSNSRMLFGLSVQGNAPKFLTRVSRRGVPINSLMLSGAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLAHLRFRAAMRRQGRETQFKALLYPFGNYLCIAFLGMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J54</accession>
    <name>KAD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenylate kinase</fullName>
            <shortName evidence="2">AK</shortName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adk</name>
        <name type="ordered locus">SDY_0445</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019454.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402142.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J54"/>
    <dbReference type="SMR" id="Q32J54"/>
    <dbReference type="STRING" id="300267.SDY_0445"/>
    <dbReference type="EnsemblBacteria" id="ABB60653">
        <property type="protein sequence ID" value="ABB60653"/>
        <property type="gene ID" value="SDY_0445"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0445"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.528"/>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_6"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000058905" description="Adenylate kinase">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="2">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <sequence length="214" mass="23514" checksum="3807BD32E00A8358" modified="2005-12-06" version="1">MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKGRIAQEDCRNGFLLDGFPRTIPQADAMKEAGINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYHQMTAPLIGYYSKEAEAGNTKYAKVDGTKPVAEVRADLEKILG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JD0</accession>
    <name>IRAP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anti-adapter protein IraP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iraP</name>
        <name type="ordered locus">SDY_0363</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with RssB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IraP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000792965.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402066.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JD0"/>
    <dbReference type="SMR" id="Q32JD0"/>
    <dbReference type="STRING" id="300267.SDY_0363"/>
    <dbReference type="EnsemblBacteria" id="ABB60577">
        <property type="protein sequence ID" value="ABB60577"/>
        <property type="gene ID" value="SDY_0363"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0363"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.428"/>
    <dbReference type="HOGENOM" id="CLU_169517_0_0_6"/>
    <dbReference type="OMA" id="IDTAMIH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01198">
        <property type="entry name" value="Anti_adapt_IraP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019732">
        <property type="entry name" value="SigmaS_Anti-adapt_IraP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10796">
        <property type="entry name" value="Anti-adapt_IraP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000337865" description="Anti-adapter protein IraP">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01198"/>
        </source>
    </evidence>
    <sequence length="86" mass="9923" checksum="061DC9028C986BEE" modified="2005-12-06" version="1">MKNLIAELLFKLALKEEESKELCAQVEALEIIVTAMLRNMAQNDQQRLIDQVEGALYEVKPDASIPDDDTELLRDYVKKLLKHPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JG6</accession>
    <name>Q32JG6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3251 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yajI</name>
        <name evidence="3" type="ordered locus">SDY_0322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JG6"/>
    <dbReference type="STRING" id="300267.SDY_0322"/>
    <dbReference type="EnsemblBacteria" id="ABB60541">
        <property type="protein sequence ID" value="ABB60541"/>
        <property type="gene ID" value="SDY_0322"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0322"/>
    <dbReference type="HOGENOM" id="CLU_100508_0_0_6"/>
    <dbReference type="OMA" id="GTVEWGQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021658">
        <property type="entry name" value="DUF3251"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037125">
        <property type="entry name" value="YajI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11622">
        <property type="entry name" value="DUF3251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3251" evidence="2">
        <location>
            <begin position="40"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="199" mass="21888" checksum="F328D7279FCB457E" modified="2005-12-06" version="1">MLSLLLPSTIRLIATRKGRPMNTNVFRLLLLGSLFSLSACVQQSELRQMKHSVSTLNQEMTQLNQETVKITQQNRLNAKSSSGVYFLPGTKTPARLESQIGTLRMSLVNITPDTDGTTLTLRIQGESNDPLPAFSGTVEYGQIQGTIDNFQEINVQNQLINAPASVLAPSDVDIPLQLKGISVDELGFVRIHDIQPVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JL1</accession>
    <name>Q32JL1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ppiB</name>
        <name evidence="7" type="ordered locus">SDY_0277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000256002.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401985.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JL1"/>
    <dbReference type="SMR" id="Q32JL1"/>
    <dbReference type="STRING" id="300267.SDY_0277"/>
    <dbReference type="EnsemblBacteria" id="ABB60496">
        <property type="protein sequence ID" value="ABB60496"/>
        <property type="gene ID" value="SDY_0277"/>
    </dbReference>
    <dbReference type="GeneID" id="67416398"/>
    <dbReference type="KEGG" id="sdy:SDY_0277"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.317"/>
    <dbReference type="HOGENOM" id="CLU_012062_16_9_6"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044665">
        <property type="entry name" value="E_coli_cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43246">
        <property type="entry name" value="PTHR43246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="164" mass="18167" checksum="4D5C7D2D8AA9D2A0" modified="2005-12-06" version="1">MVTFHTNHGDIVIKTFDDKAPETVKNFLDYCREGFYNNTIFHRVINGFMIQGGGFEPGMKQKATKEPIKNEANNGLKNTRGTLAMARTQAPHSATAQFFINVVDNDFLNFSGESLQGWGYCVFAEVVEGMDVVDKIKGVATGRSGMHQDVPKEDVIIESVTVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JN1</accession>
    <name>Q32JN1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yafL</name>
        <name evidence="4" type="ordered locus">SDY_0253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378552.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401965.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JN1"/>
    <dbReference type="STRING" id="300267.SDY_0253"/>
    <dbReference type="EnsemblBacteria" id="ABB60476">
        <property type="protein sequence ID" value="ABB60476"/>
        <property type="gene ID" value="SDY_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0253"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.285"/>
    <dbReference type="HOGENOM" id="CLU_016043_2_1_6"/>
    <dbReference type="OMA" id="RYGPGYT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220794" evidence="2">
        <location>
            <begin position="26"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="116"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="249" mass="28839" checksum="4D1DAD7070A33100" modified="2005-12-06" version="1">MSLPSIPSFVLSGLLLICLPFSSFASATTSHISFSYAARQRMQNRARLLKQYQTHLKKQASYIVEGNAESRRALRQHNREQIKQHPEWFPARLKASDRRWQALAENNHFLSSDHLHNITEVAIHRLEQQLGKPYVWGGTRPDKGFDCSGLVFYAYNKLLEAKLPRTANEMYHYHRATIVANNDLRRGDLLFFHIHSREIADHMGVYLGDGQFIESPRTGETIRVSRLAEPFWQDHFLGARRILTEETIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JP3</accession>
    <name>Q32JP3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0017</name>
        <name evidence="4" type="ordered locus">SDY_0240</name>
        <name evidence="5" type="ordered locus">SDY_1173</name>
        <name evidence="6" type="ordered locus">SDY_2256</name>
        <name evidence="7" type="ordered locus">SDY_2503</name>
        <name evidence="8" type="ordered locus">SDY_2640</name>
        <name evidence="9" type="ordered locus">SDY_3676</name>
        <name evidence="10" type="ordered locus">SDY_3865</name>
        <name evidence="11" type="ordered locus">SDY_4313</name>
        <name evidence="12" type="ordered locus">SDY_4515</name>
        <name evidence="13" type="ordered locus">SDY_4593</name>
    </gene>
    <organism evidence="4 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60257">
        <property type="protein sequence ID" value="ABB60257"/>
        <property type="gene ID" value="SDY_0017"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60464">
        <property type="protein sequence ID" value="ABB60464"/>
        <property type="gene ID" value="SDY_0240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61330">
        <property type="protein sequence ID" value="ABB61330"/>
        <property type="gene ID" value="SDY_1173"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62336">
        <property type="protein sequence ID" value="ABB62336"/>
        <property type="gene ID" value="SDY_2256"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62573">
        <property type="protein sequence ID" value="ABB62573"/>
        <property type="gene ID" value="SDY_2503"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62693">
        <property type="protein sequence ID" value="ABB62693"/>
        <property type="gene ID" value="SDY_2640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63641">
        <property type="protein sequence ID" value="ABB63641"/>
        <property type="gene ID" value="SDY_3676"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63807">
        <property type="protein sequence ID" value="ABB63807"/>
        <property type="gene ID" value="SDY_3865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64209">
        <property type="protein sequence ID" value="ABB64209"/>
        <property type="gene ID" value="SDY_4313"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64389">
        <property type="protein sequence ID" value="ABB64389"/>
        <property type="gene ID" value="SDY_4515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64453">
        <property type="protein sequence ID" value="ABB64453"/>
        <property type="gene ID" value="SDY_4593"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0017"/>
    <dbReference type="KEGG" id="sdy:SDY_0240"/>
    <dbReference type="KEGG" id="sdy:SDY_1173"/>
    <dbReference type="KEGG" id="sdy:SDY_2256"/>
    <dbReference type="KEGG" id="sdy:SDY_2503"/>
    <dbReference type="KEGG" id="sdy:SDY_2640"/>
    <dbReference type="KEGG" id="sdy:SDY_3676"/>
    <dbReference type="KEGG" id="sdy:SDY_3865"/>
    <dbReference type="KEGG" id="sdy:SDY_4313"/>
    <dbReference type="KEGG" id="sdy:SDY_4515"/>
    <dbReference type="KEGG" id="sdy:SDY_4593"/>
    <dbReference type="HOGENOM" id="CLU_203300_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB64209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB64389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB64453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="60" mass="6998" checksum="D415D2CF419C31F6" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGYWPTLLVPVPMKPAGNYWHCLRHSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JR4</accession>
    <name>Q32JR4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yaeF</name>
        <name evidence="2" type="ordered locus">SDY_0212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401932.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JR4"/>
    <dbReference type="STRING" id="300267.SDY_0212"/>
    <dbReference type="EnsemblBacteria" id="ABB60443">
        <property type="protein sequence ID" value="ABB60443"/>
        <property type="gene ID" value="SDY_0212"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0212"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.246"/>
    <dbReference type="HOGENOM" id="CLU_093835_0_0_6"/>
    <dbReference type="OMA" id="AWFCSEF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024453">
        <property type="entry name" value="Peptidase_C92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05708">
        <property type="entry name" value="Peptidase_C92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221050" evidence="1">
        <location>
            <begin position="26"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="274" mass="30014" checksum="DEC91D474DA3503A" modified="2005-12-06" version="1">MDKPKAYYRLLLPSFLLLSACTVDISQPDSSATAVDVEAKTWAVKFQHQSSFTEQSIKEITVPDLKPGDLLFSSSLGITSFGIRVFSTSSVSHVAIYLGENNVAEATGAGVQIVSLKKAMKHSDKLFVLRVPDLTPQQATEITAFANKIKDSGYNYRGIVEFIPFMVTRQMCSLNPFSEDFRQQCVSGLAKAQLSSVGEGDKKSWFCSEFVTDAFAKAGHPLTLAQSGWISPADLMHMRIGDVSAFKPETQLQYVGHLKPGIYIKAGRFVGLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JW0</accession>
    <name>Q32JW0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yadP</name>
        <name evidence="2" type="synonym">thpR</name>
        <name evidence="4" type="ordered locus">SDY_0163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401886.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JW0"/>
    <dbReference type="STRING" id="300267.SDY_0163"/>
    <dbReference type="EnsemblBacteria" id="ABB60397">
        <property type="protein sequence ID" value="ABB60397"/>
        <property type="gene ID" value="SDY_0163"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0163"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.186"/>
    <dbReference type="HOGENOM" id="CLU_081251_2_1_6"/>
    <dbReference type="OMA" id="AARNGCY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="95"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="179" mass="20317" checksum="5025F388733C1BAA" modified="2005-12-06" version="1">MPHMSDPQRLFFAIDLPAEIREQIIHWRATHFPLEAGRPVAADNLHLTLAFLGEVSAEKEKALSLLAGRIRQPGFTLTLDDAGQWLRSRVVWLGMRQPPRGLIQLANMLRSQSARSGCFQSNRPFHPHITLLRDASEAVTIPPPGFNWSYAVTEFTLYASSFARGRTRYTPLKRWALTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JX0</accession>
    <name>Q32JX0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JX0"/>
    <dbReference type="EnsemblBacteria" id="ABB60387">
        <property type="protein sequence ID" value="ABB60387"/>
        <property type="gene ID" value="SDY_0153"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0153"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="9337" checksum="5CAA7F300F1AA09C" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITKWGNIVQNKSETVPHRFLLIFHFKTAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JY3</accession>
    <name>Q32JY3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulates ampC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ampD</name>
        <name evidence="2" type="ordered locus">SDY_0140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000923715.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401863.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JY3"/>
    <dbReference type="STRING" id="300267.SDY_0140"/>
    <dbReference type="EnsemblBacteria" id="ABB60374">
        <property type="protein sequence ID" value="ABB60374"/>
        <property type="gene ID" value="SDY_0140"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0140"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.158"/>
    <dbReference type="HOGENOM" id="CLU_049290_1_0_6"/>
    <dbReference type="OMA" id="PFTDAQY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="183" mass="20528" checksum="DBF27FDF02D1A6A8" modified="2005-12-06" version="1">MLLEQGWLVGARRVPSPHYDCRPDDETPTLLVVHNISLPPGEFGGPWIDALFTGTIDPQAHPFFAEIAHLRVSAHCFIRRDGEIVQYVPFDKRAWHAGVSQYQGRERCNDFSIGIELEGTDTLAYTDAQYQQLAAVTRALIDCYPDIANNMTGHCDIAPDRKTDPGPAFDWARFRALVSKETT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K10</accession>
    <name>RSMH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmH</name>
        <name type="synonym">mraW</name>
        <name type="ordered locus">SDY_0112</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000970466.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401836.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K10"/>
    <dbReference type="SMR" id="Q32K10"/>
    <dbReference type="STRING" id="300267.SDY_0112"/>
    <dbReference type="EnsemblBacteria" id="ABB60347">
        <property type="protein sequence ID" value="ABB60347"/>
        <property type="gene ID" value="SDY_0112"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0112"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.131"/>
    <dbReference type="HOGENOM" id="CLU_038422_2_0_6"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000223564" description="Ribosomal RNA small subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <sequence length="313" mass="34853" checksum="46BCED906B3A47A0" modified="2005-12-06" version="1">MMENYKHTTVLLDEAVNGLNIRPDGIYIDGTFGRGGHSRLILSQLGEEGRLLAIDRDPQAIAVAKTIDDPRFSIIHGPFSALGEYVAERDLIGKIDGILLDLGVSSPQLDDAERGFSFMRDGPLDMRMDPTCGQSAAEWLQTAEEADIAWVLKTYGEERFAKRIARAIVERNREQPMTRTKELAEVVAAATPVKDKFKHPATRTFQAVRIWVNSELEEIEQALKSSLNVLAPGGRLSIISFHSLEDRIVKRFMRENSRGPQVPAGLPMTEEQLKKLGGRQLRALGKLMPGEEEVAENPRARSSVLRIAERTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K47</accession>
    <name>Q32K47_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative antitoxin of gyrase inhibiting toxin-antitoxin system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000125565.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401799.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K47"/>
    <dbReference type="EnsemblBacteria" id="ABB60310">
        <property type="protein sequence ID" value="ABB60310"/>
        <property type="gene ID" value="SDY_0072"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0072"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.82"/>
    <dbReference type="HOGENOM" id="CLU_157097_2_2_6"/>
    <dbReference type="OMA" id="CFGDEFR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009956">
        <property type="entry name" value="Post-segregation_anti-tox_CcdA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07362">
        <property type="entry name" value="CcdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="77" mass="8600" checksum="4B85DE437183A251" modified="2005-12-06" version="1">MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K77</accession>
    <name>Q32K77_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yadD</name>
        <name evidence="3" type="ordered locus">SDY_0042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401769.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K77"/>
    <dbReference type="EnsemblBacteria" id="ABB60280">
        <property type="protein sequence ID" value="ABB60280"/>
        <property type="gene ID" value="SDY_0042"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0042"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.46"/>
    <dbReference type="HOGENOM" id="CLU_059548_1_2_6"/>
    <dbReference type="OMA" id="RVYNNPF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="2">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="266" mass="30725" checksum="EA14940AE6F33E8F" modified="2005-12-06" version="1">MDAPSTTPHDAVFKQFLMHAETARDFLEIHLPVELRELCDLNTLHLESGSFIEESLKGHSTDVRYSVQMQGNPGYLHVVIEHQSKPDKKMAFRMMRYSIAAMHRHLEADHDKLPLVVPILFYQGEATPYPLSMCWFDMFYSPELARRVYNSPFPLVDITITPDDEIMQHRRIAILELLQKHIRQRDLMLLLEQLVTLIDEGYTSGSQLVAMQNYMLQRGHTEQADLFYGVLRDRETGGKSMMTLAQWFEEKGIEKGMEGDAANLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K83</accession>
    <name>Q32K83_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yadG</name>
        <name evidence="5" type="ordered locus">SDY_0036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000150645.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401763.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K83"/>
    <dbReference type="STRING" id="300267.SDY_0036"/>
    <dbReference type="EnsemblBacteria" id="ABB60274">
        <property type="protein sequence ID" value="ABB60274"/>
        <property type="gene ID" value="SDY_0036"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0036"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.40"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_6"/>
    <dbReference type="OMA" id="CEGYRRP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="308" mass="34675" checksum="992964F9A6BD5B6C" modified="2005-12-06" version="1">MTIALELQQLKKTYPGGVQVLRGIDLQVEAGDFYALLGPNGAGKSTTIGIISSLVNKTSGRVSVFGYDLEKDVVNAKRQLGLVPQEFNFNPFETVQQIVVNQAGYYGVERKEAYIRSEKYLKQLDLWGKRNERARMLSGGMKRRLMIARALMHEPKLLILDEPTAGVDIELRRSMWGFLKDLNDKGTTIILTTHYLEEAEMLCRNIGIIQHGELVENTSMKALLAKLKSETFILDLAPKSPLPKLDGYQYRLVDTATLEVEVLREQGINSVFTQLSEQGIQVLSMRNKANRLEELFVSLVNEKQGDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K97</accession>
    <name>Q32K97_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K97"/>
    <dbReference type="EnsemblBacteria" id="ABB60261">
        <property type="protein sequence ID" value="ABB60261"/>
        <property type="gene ID" value="SDY_0021"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0021"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="74" mass="8426" checksum="E8FBE2E34DE81DBD" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITLYQIVPTPQTFFQERLFLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KB3</accession>
    <name>Q32KB3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000738713.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401733.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KB3"/>
    <dbReference type="STRING" id="300267.SDY_0005"/>
    <dbReference type="EnsemblBacteria" id="ABB60245">
        <property type="protein sequence ID" value="ABB60245"/>
        <property type="gene ID" value="SDY_0005"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0005"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4"/>
    <dbReference type="HOGENOM" id="CLU_135700_2_1_6"/>
    <dbReference type="OMA" id="GPPGHWR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019638">
        <property type="entry name" value="DUF2502"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10697">
        <property type="entry name" value="DUF2502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221178" evidence="2">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="98" mass="11457" checksum="3F07D3D22AEA277A" modified="2005-12-06" version="1">MKKMQSIVLALSLVLFAPMATQAAEITLVPSVKLQIGDRDNRGYYWDGGHWRDHGWWKQHYEWRGNRWHPHGPPPPPRHHKKAHHDHHGGHGPGKHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q326P0</accession>
    <name>Q326P0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative IS91 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000124081.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406206.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326P0"/>
    <dbReference type="EnsemblBacteria" id="ABB64718">
        <property type="protein sequence ID" value="ABB64718"/>
        <property type="gene ID" value="SDY_P205"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P205"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5759"/>
    <dbReference type="HOGENOM" id="CLU_165365_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="85" mass="10024" checksum="2BBBD624026C88F9" modified="2005-12-06" version="1">MARSAKPRKRKPAPQRSKLLRYVVKLHEDDFFDEEEAEVLRFDNFDDAVECCADLNIPFFVDAGNKKLVFWFVRVDDEGYPEIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q326R8</accession>
    <name>Q326R8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mxiJ</name>
        <name evidence="12" type="ordered locus">SDY_P177</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="12 13">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Sd197</strain>
            <plasmid evidence="13">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the YscJ lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000621939.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406178.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326R8"/>
    <dbReference type="EnsemblBacteria" id="ABB64690">
        <property type="protein sequence ID" value="ABB64690"/>
        <property type="gene ID" value="SDY_P177"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P177"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5733"/>
    <dbReference type="HOGENOM" id="CLU_073268_2_0_6"/>
    <dbReference type="OMA" id="IKYRESA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003282">
        <property type="entry name" value="T3SS_HrcJ/YscJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01338">
        <property type="entry name" value="TYPE3OMKPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02544">
        <property type="entry name" value="III_secr_YscJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="11">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB64690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="241" mass="27543" checksum="97C2892DCFE843CF" modified="2005-12-06" version="1">MIRYKFFILFLLLMLIGCEQRDELISNLSQRQANEIISVLERHNISARKVDGGKQGISVQVEKGTFASAVDLMRMYDLPNPERVDISQMFPTDSLVSSPRAEKARLYSAIEQRLEQSLVSIGGVISAKIHVSYDLDDKNISSKPMHISVIAIYDSPKESELLVSNIKRFLKNTFSDVKYENISVILTPKEEYVYTNVQPVKETKSEFLINEVIYVFLGMAVLVVILLVWAFKTGWFKRNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q326U4</accession>
    <name>Q326U4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OspC3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ospC3</name>
        <name evidence="10" type="ordered locus">SDY_P151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Sd197</strain>
            <plasmid evidence="11">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-arginyl-[protein] + NAD(+) = ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:69500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:17719"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:184300"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:69501"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the OspC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011379007.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406152.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326U4"/>
    <dbReference type="EnsemblBacteria" id="ABB64664">
        <property type="protein sequence ID" value="ABB64664"/>
        <property type="gene ID" value="SDY_P151"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P151"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5707"/>
    <dbReference type="HOGENOM" id="CLU_053336_0_0_6"/>
    <dbReference type="OMA" id="MNNNRYC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010366">
        <property type="entry name" value="OspC1-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06128">
        <property type="entry name" value="Shigella_OspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="484" mass="55630" checksum="FA4BD64A9344A184" modified="2005-12-06" version="1">MKIPEAVNHINVQNNVDLVDGKTNPNKATKALQKNILRVTNSSSSGISEKHLDHCANTVKNFLRKSIAAQSYSKMFSQGTSFKSLNLSIEAPSGARSSFRSLEHLDKVSRHYISEIIQKVHPLSSDERHLLSIIINSNFNFRHQSNSNLSNNILNIKSFDKIQSENIQTHKNTYSEDIKEISNHDFVFFGVEISNHQEKLPLNKTHHTVDFGANAYIIDHDSPYGYMTLTDHFDNAIPPVFYHEHQSFFLDNFKEVVDEVSRYVHGNQGKTDVPIFNTKDMRLGIGLHLIDFIRKSKDQGFREFCYNKNIDPVSLDRIINFVFQLEYHIPRMLSTDNFKKIKLRDISLEDAIKASNYEEINNKVTDKKMAHQALAYSLGNKKADIALYLLSKFNFTKQDVAEMEKMNNNRYCNLYDVEYLLSKDGANYKVLEYFINNGLVDVNKKFQKVNSGDTMLDNAMKSKDSKMIDFLLKNGAILGKRFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q326V1</accession>
    <name>Q326V1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000405248.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406145.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326V1"/>
    <dbReference type="EnsemblBacteria" id="ABB64657">
        <property type="protein sequence ID" value="ABB64657"/>
        <property type="gene ID" value="SDY_P144"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P144"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5701"/>
    <dbReference type="HOGENOM" id="CLU_101288_0_0_6"/>
    <dbReference type="OMA" id="CAEFIEY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="160" mass="17736" checksum="4C6598F45C2FA165" modified="2005-12-06" version="1">MEINVTAPALLTDEHILQPFDCGNEVLSNWLRGRAMKNQMLNASRTFVICLEDTLRVVGYYSLATGSVTHAELGRSLRHNMPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVVNLADQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPNTLFYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q326X8</accession>
    <name>Q326X8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">traD</name>
        <name evidence="3" type="ordered locus">SDY_P117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406118.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326X8"/>
    <dbReference type="EnsemblBacteria" id="ABB64630">
        <property type="protein sequence ID" value="ABB64630"/>
        <property type="gene ID" value="SDY_P117"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P117"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5672"/>
    <dbReference type="HOGENOM" id="CLU_016763_5_1_6"/>
    <dbReference type="OMA" id="FITWRED"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="CDD" id="cd01127">
        <property type="entry name" value="TrwB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014128">
        <property type="entry name" value="T4SS_TraD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019476">
        <property type="entry name" value="T4SS_TraD_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10412">
        <property type="entry name" value="TrwB_AAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02759">
        <property type="entry name" value="TraD_Ftype"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwB_AAD_bind" evidence="2">
        <location>
            <begin position="58"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="504" mass="56775" checksum="FF97EC0AF7D2F914" modified="2005-12-06" version="1">MSVKLRLPQITFFVVSWILGRQGKQQSENEVTGGRQLTDNPKEVARMLKKGGEDSDIRIGDLPIIRDSEIKNFCLHGTVGAGKSEVIRRLANYARKRGDMVVIYDRSCEFVKSYYDPSIDNILNPLDVRCAAWDLWKECLTQPDFDNVANTLIPMGTKEAPFWQGSGRTIFAEAAYLMRNDPNRSYSKLVDTLLSIKIEKLRTFLRNSPAANLVEEKIEKTAISIRAVLTNYVKAIRYLQRIEHNGESFTIRDWMRGVREDKKNGWLFISSNADTHASLKPVISMWLSIAIRGLMAMGGNRNRRVWFFCDELPTLHKLPDLVEILPEARKFGGCYVFGIQSYAQLEDIYGEKAAATLFDVMNTRAFFRSPSHKIAEFAAGEIGEKEHLKASEQYSYGADPVRDGVSTGKDMERQTLVSYSDIQSLPDLTCYVTLPGPYPAVKLSLKYQARPKVAPEFIPREINPENGEPSECRACCKGSRRSSDGQPLRTGCPGGCIRRGRDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q327F6</accession>
    <name>Q327F6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406040.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327F6"/>
    <dbReference type="EnsemblBacteria" id="ABB64552">
        <property type="protein sequence ID" value="ABB64552"/>
        <property type="gene ID" value="SDY_P039"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P039"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5583"/>
    <dbReference type="HOGENOM" id="CLU_027402_41_1_6"/>
    <dbReference type="OMA" id="ITHWIER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="124" mass="14571" checksum="7F69522590965D82" modified="2005-12-06" version="1">MTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTPKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q327L8</accession>
    <name>Q327L8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mg-dependent DNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjjV</name>
        <name evidence="1" type="ordered locus">SDY_4638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000563007.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405978.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327L8"/>
    <dbReference type="STRING" id="300267.SDY_4638"/>
    <dbReference type="EnsemblBacteria" id="ABB64487">
        <property type="protein sequence ID" value="ABB64487"/>
        <property type="gene ID" value="SDY_4638"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4638"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5498"/>
    <dbReference type="HOGENOM" id="CLU_031506_0_1_6"/>
    <dbReference type="OMA" id="CHLDAGE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="260" mass="28964" checksum="12E16BBB16EDAB69" modified="2005-12-06" version="1">MICRFIDTHCHFDFLPFSGDEEASLQRAAQAGVGKIIVPATEAENFARVQALAEKYQPLYAALGLHPGMLEKHSDVSLDQLQQALERRPAKVVAVGESGLDLFGDDPQFERQQWLLDEQLKLAKRYDLPVILHSRRAHDKLAMHLKRHDLSRTGVVHGFSGSLQQAERFVQLGYKIGVGGTITYPRASKTRDVIAKLPLASLLLETDAPDMPLNGFQGQPNRPEQAVRVFDVLCELRPEPEDEIAEVLLNNTYALFSVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q327T2</accession>
    <name>Q327T2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yhjR</name>
        <name evidence="1" type="ordered locus">SDY_4555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001063314.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405914.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327T2"/>
    <dbReference type="STRING" id="300267.SDY_4555"/>
    <dbReference type="EnsemblBacteria" id="ABB64423">
        <property type="protein sequence ID" value="ABB64423"/>
        <property type="gene ID" value="SDY_4555"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4555"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5387"/>
    <dbReference type="HOGENOM" id="CLU_185167_0_0_6"/>
    <dbReference type="OMA" id="MMTRWPL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024487">
        <property type="entry name" value="YhjR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10945">
        <property type="entry name" value="CBP_BcsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="62" mass="7032" checksum="70BC8B409ED21D91" modified="2005-12-06" version="1">MNNNEPDTLPDPAIGYIFQNDILALKQAFSLPDIDYADISQREQLAAALKRWPLLAEFAQQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q327U8</accession>
    <name>PLSB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate acyltransferase</fullName>
            <shortName evidence="1">GPAT</shortName>
            <ecNumber evidence="1">2.3.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsB</name>
        <name type="ordered locus">SDY_4533</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:15325"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="2.3.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327U8"/>
    <dbReference type="SMR" id="Q327U8"/>
    <dbReference type="STRING" id="300267.SDY_4533"/>
    <dbReference type="EnsemblBacteria" id="ABB64407">
        <property type="protein sequence ID" value="ABB64407"/>
        <property type="gene ID" value="SDY_4533"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4533"/>
    <dbReference type="HOGENOM" id="CLU_015407_0_0_6"/>
    <dbReference type="OMA" id="EVIYVPC"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102420">
        <property type="term" value="F:sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00393">
        <property type="entry name" value="Glyc3P_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028354">
        <property type="entry name" value="GPAT_PlsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="PTHR12563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500064">
        <property type="entry name" value="GPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000437">
        <property type="entry name" value="GPAT_DHAPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03703">
        <property type="entry name" value="plsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000049465" description="Glycerol-3-phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXXXXD motif">
        <location>
            <begin position="325"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00393"/>
        </source>
    </evidence>
    <sequence length="827" mass="93696" checksum="30DF48AC985EB183" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q327V4</accession>
    <name>Q327V4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405892.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327V4"/>
    <dbReference type="EnsemblBacteria" id="ABB64401">
        <property type="protein sequence ID" value="ABB64401"/>
        <property type="gene ID" value="SDY_4527"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4527"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5350"/>
    <dbReference type="HOGENOM" id="CLU_2261920_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="108" mass="12027" checksum="2FDA7CE4B7571567" modified="2005-12-06" version="1">MPVVPGRFHRYGDQKCRPVPPLFWCYTRTRASVAGLTGLISVSELKNAVAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITISYLLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q328K0</accession>
    <name>ULAF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-ribulose-5-phosphate 4-epimerase UlaF</fullName>
            <ecNumber evidence="1">5.1.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-ascorbate utilization protein F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribulose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ulaF</name>
        <name type="ordered locus">SDY_4367</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:22368"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58226"/>
            <dbReference type="EC" id="5.1.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor degradation; L-ascorbate degradation; D-xylulose 5-phosphate from L-ascorbate: step 4/4.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">Induced by L-ascorbate. Repressed by UlaR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. AraD/FucA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001170811.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405746.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328K0"/>
    <dbReference type="SMR" id="Q328K0"/>
    <dbReference type="STRING" id="300267.SDY_4367"/>
    <dbReference type="EnsemblBacteria" id="ABB64255">
        <property type="protein sequence ID" value="ABB64255"/>
        <property type="gene ID" value="SDY_4367"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4367"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5156"/>
    <dbReference type="HOGENOM" id="CLU_006033_5_0_6"/>
    <dbReference type="OMA" id="SWLMNKH"/>
    <dbReference type="UniPathway" id="UPA00263">
        <property type="reaction ID" value="UER00380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008742">
        <property type="term" value="F:L-ribulose-phosphate 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019854">
        <property type="term" value="P:L-ascorbic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01952">
        <property type="entry name" value="UlaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023499">
        <property type="entry name" value="UlaF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000233248" description="L-ribulose-5-phosphate 4-epimerase UlaF">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01952"/>
        </source>
    </evidence>
    <sequence length="228" mass="25339" checksum="595842F35008EE95" modified="2005-12-06" version="1">MQKLKQQVFEANMDLPRYGLVTFTWGNVSAIDRERGLVVIKPSGVAYETMKADDMVVVDMSGKVVEGEYRPSSDTATHLELYRRYPSLGGIVHTHSTHATAWAQAGLAIPALGTTHADYFFGDIPCTRGLSEEEVQGEYELNTGKVIIETLGNAEPLHTPGIVVYQHGPFAWGKDAHDAVHNAVVMEEVAKMAWIARSINPQLNHIDSFLMNEHFMRKHGPNAYYGQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q328K1</accession>
    <name>ULAD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-keto-L-gulonate-6-phosphate decarboxylase UlaD</fullName>
            <ecNumber evidence="1">4.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">3-dehydro-L-gulonate-6-phosphate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">KGPDC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">L-ascorbate utilization protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ulaD</name>
        <name type="ordered locus">SDY_4365</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydro-L-gulonate 6-phosphate + H(+) = CO2 + L-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14353"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57829"/>
            <dbReference type="ChEBI" id="CHEBI:58774"/>
            <dbReference type="EC" id="4.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor degradation; L-ascorbate degradation; D-xylulose 5-phosphate from L-ascorbate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">Induced by L-ascorbate. Repressed by UlaR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HPS/KGPDC family. KGPDC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000056752.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405745.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328K1"/>
    <dbReference type="SMR" id="Q328K1"/>
    <dbReference type="STRING" id="300267.SDY_4365"/>
    <dbReference type="EnsemblBacteria" id="ABB64254">
        <property type="protein sequence ID" value="ABB64254"/>
        <property type="gene ID" value="SDY_4365"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4365"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5153"/>
    <dbReference type="HOGENOM" id="CLU_081825_0_0_6"/>
    <dbReference type="OMA" id="WEQAQEW"/>
    <dbReference type="UniPathway" id="UPA00263">
        <property type="reaction ID" value="UER00378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033982">
        <property type="term" value="F:3-dehydro-L-gulonate-6-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019854">
        <property type="term" value="P:L-ascorbic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04726">
        <property type="entry name" value="KGPDC_HPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01267">
        <property type="entry name" value="UlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023942">
        <property type="entry name" value="3-keto-L-gulonate6Pdecase_UlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041710">
        <property type="entry name" value="HPS/KGPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000236096" description="3-keto-L-gulonate-6-phosphate decarboxylase UlaD">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01267"/>
        </source>
    </evidence>
    <sequence length="216" mass="23506" checksum="EC8493B97D01BB44" modified="2005-12-06" version="1">MSLPMLQVALDNQTMDSAYETTRLIAEEVDIIEVGTILCVGEGVRAVRDLKALYPHKIVLADAKIADAGKILSRMCFEANADWVTVICCADINTAKGALDVAKEFNGDVQIELTGYWTWEQAQQWRDAGIGQVVYHRSRDAQAAGVAWGGADITAIKRLSDMGFKVTVTGGLALEDLPLFKGIPIHVFIAGRSIRDAASPVEAARQFKRSIAELWG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q328K4</accession>
    <name>ULAA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ascorbate-specific PTS system EIIC component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ascorbate-specific permease IIC component UlaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ulaA</name>
        <name type="ordered locus">SDY_4362</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">Induced by L-ascorbate. Repressed by UlaR.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">In classical PTS systems, the PTS EIIC type-2 domain forms the translocation channel and contains the specific substrate-binding site. UlaA does not exhibit the topological features of any recognized enzyme IIC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UlaA family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB64251" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64251.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021471.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405742.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328K4"/>
    <dbReference type="SMR" id="Q328K4"/>
    <dbReference type="STRING" id="300267.SDY_4362"/>
    <dbReference type="EnsemblBacteria" id="ABB64251">
        <property type="protein sequence ID" value="ABB64251"/>
        <property type="gene ID" value="SDY_4362"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4362"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5150"/>
    <dbReference type="HOGENOM" id="CLU_031784_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004703">
        <property type="entry name" value="PTS_sugar-sp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03611">
        <property type="entry name" value="EIIC-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0598">Phosphotransferase system</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000230662" description="Ascorbate-specific PTS system EIIC component">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P39301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="465" mass="50750" checksum="56933414A785A710" modified="2006-04-04" version="2">MEILYNIFTVFFNQVMTNAPLLLGIVTCLGYILLRKSVSVIIKGTIKTIIGFMLLQAGSGILTSTFKPVVAKMSEVYGINGAISDNYASMMATIDRMGDAYSWVGYAVLLALALNICYVLLRRITGIRTIMLTGHIMFQQAGLIAVTLFIFGYSMWTTIICTAILVSLYWGITSNMMYKPTQEVTDGCGFSIGHQQQFASWIAYKVAPFLGKKEESVEDLKLPGWLNIFHDNIVSTAIVMTIFFGAILLSFGIDTVQAMAGKVHWTVYILQTGFSFAVAIFIITQGVRMFVAELSEAFNGISQRLIPGAVLAIDCAAIYSFAPNAVVWGFMWGTIGQLIAVGILVACGSSILIIPGFIPMFFSNATIGVFANHFGGWRAALKICLVMGMIEIFGCVWAVKLTGMSAWMGMADWSILAPPMMQGFFSIGIAFMAVIIVIALAYMFFAGRALRAEEDAEKQLAEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q328P2</accession>
    <name>Q328P2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alpha helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yjbB</name>
        <name evidence="8" type="ordered locus">SDY_4319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405704.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328P2"/>
    <dbReference type="STRING" id="300267.SDY_4319"/>
    <dbReference type="EnsemblBacteria" id="ABB64213">
        <property type="protein sequence ID" value="ABB64213"/>
        <property type="gene ID" value="SDY_4319"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4319"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5098"/>
    <dbReference type="HOGENOM" id="CLU_025623_2_1_6"/>
    <dbReference type="OMA" id="FCAVAYN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004633">
        <property type="entry name" value="NaPi_cotrn-rel/YqeW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01013">
        <property type="entry name" value="2a58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00704">
        <property type="entry name" value="NaPi_cotrn_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="518" mass="56771" checksum="9F7ADA04B38A32D6" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q328U2</accession>
    <name>Q328U2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjgF</name>
        <name evidence="3" type="ordered locus">SDY_4262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405654.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328U2"/>
    <dbReference type="STRING" id="300267.SDY_4262"/>
    <dbReference type="EnsemblBacteria" id="ABB64163">
        <property type="protein sequence ID" value="ABB64163"/>
        <property type="gene ID" value="SDY_4262"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4262"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5025"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_1_6"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="141" mass="15170" checksum="ACBE54CA5DE1B968" modified="2005-12-06" version="1">MSQTFYRCNKGEIMSKTIATENAPAAIGPYVQGVDLGNMIITSGQIPVNPKTGEVPADVAAQARQSLDNVKAIVEAAGLKVGDIVKTTVFVKDLNDFATVNATYEAFFTEHNATFPARSCVEVARLPKDVKIEIEAIAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q328X2</accession>
    <name>Q328X2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anaerobic C4-dicarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dcuB</name>
        <name evidence="10" type="ordered locus">SDY_4232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 8">Cell inner membrane</location>
            <topology evidence="3 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405624.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328X2"/>
    <dbReference type="STRING" id="300267.SDY_4232"/>
    <dbReference type="EnsemblBacteria" id="ABB64133">
        <property type="protein sequence ID" value="ABB64133"/>
        <property type="gene ID" value="SDY_4232"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4232"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4986"/>
    <dbReference type="HOGENOM" id="CLU_036056_1_1_6"/>
    <dbReference type="OMA" id="DKDPEFQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015556">
        <property type="term" value="F:C4-dicarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004668">
        <property type="entry name" value="Anaer_Dcu_memb_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36106">
        <property type="entry name" value="PTHR36106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03605">
        <property type="entry name" value="DcuA_DcuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004539">
        <property type="entry name" value="C4-dicrbxl_trns"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00770">
        <property type="entry name" value="Dcu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR004539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="395" mass="42408" checksum="2AE7E4845F8F6CFA" modified="2005-12-06" version="1">MLVIIAVVAASATLQASGGLDVMLQIAEKLLRRNPKYVSIVAPFVTCILTILCGTGHVVYTILPIIYDVAIKNNIRPERPMAASSIGAQMGIIASPVSVAVVSLVAMLGNVTFDGRHLEFLDLLAITIPSTLIGILAIGIFSWFRGKDLDKDEEFQKFISVPENREYVYGDTATLLDKKLPKSNWLAMWIFLGAIAVVALLGADSDLRPSFGGKPLSMVLVIQMFMLLTGALIIILTKTNPASISKNEVFRSGMIAIVAVYGIAWMAETMFGAHMSEIQGVLGEMVKEYPWAYAIVLLLVSKFVNSQAAALAAIVPVALAIGVAPAYIVASAPACYGYYILPTYPSDLAAIQFDRSGTARIGCFVINHSFILPGLIGVSVSCVFGWIFAAMYGFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q329B8</accession>
    <name>RECF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recF</name>
        <name type="ordered locus">SDY_4182</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000060093.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405578.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329B8"/>
    <dbReference type="SMR" id="Q329B8"/>
    <dbReference type="STRING" id="300267.SDY_4182"/>
    <dbReference type="EnsemblBacteria" id="ABB64087">
        <property type="protein sequence ID" value="ABB64087"/>
        <property type="gene ID" value="SDY_4182"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4182"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4920"/>
    <dbReference type="HOGENOM" id="CLU_040267_0_0_6"/>
    <dbReference type="OMA" id="GESWSYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000236144" description="DNA replication and repair protein RecF">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <sequence length="357" mass="40552" checksum="F4DE68E3F0E0F5AF" modified="2005-12-06" version="1">MSLTRLLIRDFRNIETADLALSPGFNFLVGANGSGKTSMLEAIYTLGHGRAFRSLQIGRVIRHEQEAFVLHGRLQGEERETAIGLTKDKQGDSKVRIDGTDGHKVAELAHLMPMQLITPEGFTLLNGGPKYRRAFLDWGCFHNESGFFTAWSNLKRLLKQRNAALRQVTRYEQLRPWDKELILLAEQISTWRAEYSAGIAADMADTCKQFLPEFSLTFSFQRGWEKETEYAEVLERNFERDRQLTYTAHGPHKADLRIRADGAPVEDTLSRGQLKLLMCALRLAQGEFLTRESGRRCLYLIDDFASELDDERRGLLASRLKATQSQVFVSAISAEHVIDMSDENSKMFTVEKGKITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q329E8</accession>
    <name>Q329E8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Regulator of uhpT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">uhpC</name>
        <name evidence="9" type="ordered locus">SDY_4148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405548.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329E8"/>
    <dbReference type="STRING" id="300267.SDY_4148"/>
    <dbReference type="EnsemblBacteria" id="ABB64057">
        <property type="protein sequence ID" value="ABB64057"/>
        <property type="gene ID" value="SDY_4148"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4148"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4875"/>
    <dbReference type="HOGENOM" id="CLU_001265_31_0_6"/>
    <dbReference type="OMA" id="NAWFQGW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021159">
        <property type="entry name" value="Sugar-P_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00942">
        <property type="entry name" value="GLPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="32"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="440" mass="48362" checksum="5AABA21D1E4AD50A" modified="2005-12-06" version="1">MMLPFLKAPADAPLMTDKHEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVLKFVSGIVSDRSNARYFMGTGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKEILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGVSALLLLPFLNAQTPREA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q329T3</accession>
    <name>ASNA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Asparagine synthetase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">asnA</name>
        <name type="ordered locus">SDY_4004</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine</text>
            <dbReference type="Rhea" id="RHEA:11372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000845107.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405413.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329T3"/>
    <dbReference type="SMR" id="Q329T3"/>
    <dbReference type="STRING" id="300267.SDY_4004"/>
    <dbReference type="EnsemblBacteria" id="ABB63922">
        <property type="protein sequence ID" value="ABB63922"/>
        <property type="gene ID" value="SDY_4004"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4004"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4716"/>
    <dbReference type="HOGENOM" id="CLU_071543_0_0_6"/>
    <dbReference type="OMA" id="QSRICMF"/>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00645">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00555">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="PTHR30073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03590">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001555">
        <property type="entry name" value="Asp_ammon_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00669">
        <property type="entry name" value="asnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000017960" description="Aspartate--ammonia ligase">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00555"/>
        </source>
    </evidence>
    <sequence length="330" mass="36650" checksum="6E8D3A2ACE523FC6" modified="2005-12-06" version="1">MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLQLEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAAVRESVPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Y0</accession>
    <name>Q329Y0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Porphobilinogen deaminase</fullName>
            <shortName evidence="8">PBG</shortName>
            <ecNumber evidence="8">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="8">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hemC</name>
        <name evidence="11" type="ordered locus">SDY_3941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="8">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405366.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Y0"/>
    <dbReference type="STRING" id="300267.SDY_3941"/>
    <dbReference type="EnsemblBacteria" id="ABB63875">
        <property type="protein sequence ID" value="ABB63875"/>
        <property type="gene ID" value="SDY_3941"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3941"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4652"/>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_6"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="9">
        <location>
            <begin position="13"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="10">
        <location>
            <begin position="233"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="320" mass="34628" checksum="FBC856B2C0EBB689" modified="2005-12-06" version="1">MIMTVTSMLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDARTRELLVALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A91</accession>
    <name>Q32A91_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glpX</name>
        <name evidence="6" type="ordered locus">SDY_3819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FBPase class 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001250644.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405255.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A91"/>
    <dbReference type="SMR" id="Q32A91"/>
    <dbReference type="STRING" id="300267.SDY_3819"/>
    <dbReference type="EnsemblBacteria" id="ABB63764">
        <property type="protein sequence ID" value="ABB63764"/>
        <property type="gene ID" value="SDY_3819"/>
    </dbReference>
    <dbReference type="GeneID" id="67417564"/>
    <dbReference type="KEGG" id="sdy:SDY_3819"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4510"/>
    <dbReference type="HOGENOM" id="CLU_054938_0_0_6"/>
    <dbReference type="OMA" id="AVFYMDK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="336" mass="35852" checksum="DEC2A477E5C4062E" modified="2005-12-06" version="1">MRRELAIEFSRVTESAALAGYKWLGRGDKNTADGAAVNAMRIMLNQVNIDGTIVIGEGEIDEAPMLYIGEKVGTGRGDAVDIAVDPIEGTRMTAMGQANALAVLAVGDKGCFLNAPDMYMEKLIVGPGAKGTIDLNLPLADNLRNVAAALGKPLSELTVTILAKPRHDAVIAEMQQLGVRVFAIPDGDVAASILTCMPDSEVDVLYGIGGAPEGVVSAAVIRALDGDMNGRLLARHDVKGDNEENRRIGEQELARCKAMGIEAGKVLRLGDMARSDNVIFSATGITKGDLLEGISRKGNIATTETLLIRGKSRTIRRIQSIHYLDRKDPEMQVHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AJ5</accession>
    <name>Q32AJ5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YhfZ_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhfZ</name>
        <name evidence="2" type="ordered locus">SDY_3696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AJ5"/>
    <dbReference type="STRING" id="300267.SDY_3696"/>
    <dbReference type="EnsemblBacteria" id="ABB63660">
        <property type="protein sequence ID" value="ABB63660"/>
        <property type="gene ID" value="SDY_3696"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3696"/>
    <dbReference type="HOGENOM" id="CLU_073294_1_0_6"/>
    <dbReference type="OMA" id="IDATVWN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032791">
        <property type="entry name" value="YhfZ_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14503">
        <property type="entry name" value="YhfZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YhfZ_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="228" mass="25408" checksum="7D886248CB9F2CCC" modified="2005-12-06" version="1">MDNKVLLSHVDINNVVCAMPLPYTRLYEGLASGLKAQFDGIPFYYAHMRGADIRVECLLNGVYDMAVVSRLAAESYLTQKGLCLALELGPHTYVGEHQLICRKGESANVKRVGLDNRSADQKIMTDIFFGGSDVERVDLSYHESLQRIVKGDVDAVIWNVVAENELTMLGLEATPLTDDPRFLQATEAVVLTRVDDYPMQQLLRAVVDKHALLAHQQRVVSGEQEPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AM2</accession>
    <name>Q32AM2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferrous iron transport protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">feoA</name>
        <name evidence="4" type="ordered locus">SDY_3668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FeoA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001200455.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405124.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AM2"/>
    <dbReference type="SMR" id="Q32AM2"/>
    <dbReference type="STRING" id="300267.SDY_3668"/>
    <dbReference type="EnsemblBacteria" id="ABB63633">
        <property type="protein sequence ID" value="ABB63633"/>
        <property type="gene ID" value="SDY_3668"/>
    </dbReference>
    <dbReference type="GeneID" id="67417035"/>
    <dbReference type="KEGG" id="sdy:SDY_3668"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4352"/>
    <dbReference type="HOGENOM" id="CLU_150646_13_0_6"/>
    <dbReference type="OMA" id="MGDPVQI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8371" checksum="945AC2E01C24CC92" modified="2005-12-06" version="1">MQYTPDTAWKITGFSREISPAYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLEVEAVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AV8</accession>
    <name>Q32AV8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AV8"/>
    <dbReference type="STRING" id="300267.SDY_3573"/>
    <dbReference type="EnsemblBacteria" id="ABB63547">
        <property type="protein sequence ID" value="ABB63547"/>
        <property type="gene ID" value="SDY_3573"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3573"/>
    <dbReference type="HOGENOM" id="CLU_096037_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="134" mass="14999" checksum="D38239C7A3B802BC" modified="2005-12-06" version="1">MPNRKWILTSLIMTFFGIPILAQFLAAVVAMLGVGLTGIIEVCNILITPTIYLLLNVFMLTLGAIIIFFSGRVWAGDSAPENREIAVWRQCFFLLPALLTLVGWIITLHLADYQFRQMGAGWLANLMLPWLGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B69</accession>
    <name>Q32B69_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yrdB</name>
        <name evidence="1" type="ordered locus">SDY_3457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001070559.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404927.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B69"/>
    <dbReference type="STRING" id="300267.SDY_3457"/>
    <dbReference type="EnsemblBacteria" id="ABB63436">
        <property type="protein sequence ID" value="ABB63436"/>
        <property type="gene ID" value="SDY_3457"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3457"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4110"/>
    <dbReference type="HOGENOM" id="CLU_190004_1_0_6"/>
    <dbReference type="OMA" id="MNQSIQF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009962">
        <property type="entry name" value="DUF1488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036692">
        <property type="entry name" value="Shew3726-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07369">
        <property type="entry name" value="DUF1488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160272">
        <property type="entry name" value="SSF160272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="85" mass="9993" checksum="5A3630C9B22FFD1E" modified="2005-12-06" version="1">MNQAIQFPDREEWDENKKCVCFPALVNGMQLTCAISGDSLAYRFTGDTPEQWLASFRQHRWDLEEEAENLIQEQSEDDQGWVWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BD2</accession>
    <name>Q32BD2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipopolysaccharide export system ATP-binding protein LptB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">yhbG</name>
        <name evidence="14" type="ordered locus">SDY_3382</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000224099.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404864.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BD2"/>
    <dbReference type="SMR" id="Q32BD2"/>
    <dbReference type="STRING" id="300267.SDY_3382"/>
    <dbReference type="EnsemblBacteria" id="ABB63373">
        <property type="protein sequence ID" value="ABB63373"/>
        <property type="gene ID" value="SDY_3382"/>
    </dbReference>
    <dbReference type="GeneID" id="67415965"/>
    <dbReference type="KEGG" id="sdy:SDY_3382"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4036"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_6"/>
    <dbReference type="OMA" id="LPMYQRA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB63373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="241" mass="26801" checksum="6041495BDDCDFA72" modified="2005-12-06" version="1">MATLTAKNLAKAYKGRRVVEDVSLTVNSGEIVGLLGPNGAGKTTTFYMVVGIVPRDAGNIIIDDDDISLLPLHARARRGIGYLPQEASIFRRLSVYDNLMAVLQIRDDLSAEQREDRANELMEEFHIEHLRDSMGQSLSGGERRRVEIARALAANPKFILLDEPFAGVDPISVIDIKRIIEHLRDSGLGVLITDHNVRETLAVCERAYIVSQGHLIAHGTPTEILQDEHVKRVYLGEDFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BD5</accession>
    <name>Q32BD5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC</fullName>
            <ecNumber evidence="7 11">3.1.3.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">KDO 8-P phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">yrbI</name>
        <name evidence="14" type="ordered locus">SDY_3379</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O = 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11500"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="EC" id="3.1.3.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 11">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the KdsC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.45" evidence="7 11"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000030005.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404861.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BD5"/>
    <dbReference type="SMR" id="Q32BD5"/>
    <dbReference type="STRING" id="300267.SDY_3379"/>
    <dbReference type="EnsemblBacteria" id="ABB63370">
        <property type="protein sequence ID" value="ABB63370"/>
        <property type="gene ID" value="SDY_3379"/>
    </dbReference>
    <dbReference type="GeneID" id="66672900"/>
    <dbReference type="KEGG" id="sdy:SDY_3379"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4033"/>
    <dbReference type="HOGENOM" id="CLU_106694_0_1_6"/>
    <dbReference type="OMA" id="VFMGVEN"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00357">
        <property type="reaction ID" value="UER00475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019143">
        <property type="term" value="F:3-deoxy-manno-octulosonate-8-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB63370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="188" mass="19997" checksum="75AF512CF4E5E6E2" modified="2005-12-06" version="1">MSKAGASLATCYGPVSADVIAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGYGIRCALTSDIEVAIITGRKAKLVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENVAYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIAGGRGAVREVCDLLLLAQGKLDEAKGQSI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-03" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BF4</accession>
    <name>RLME_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase E</fullName>
            <ecNumber evidence="1">2.1.1.166</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA Um2552 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmE</name>
        <name evidence="1" type="synonym">ftsJ</name>
        <name evidence="1" type="synonym">rrmJ</name>
        <name type="ordered locus">SDY_3360</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42720"/>
            <dbReference type="Rhea" id="RHEA-COMP:10202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10203"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.166"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.166" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000145972.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404842.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BF4"/>
    <dbReference type="SMR" id="Q32BF4"/>
    <dbReference type="STRING" id="300267.SDY_3360"/>
    <dbReference type="EnsemblBacteria" id="ABB63351">
        <property type="protein sequence ID" value="ABB63351"/>
        <property type="gene ID" value="SDY_3360"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3360"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4014"/>
    <dbReference type="HOGENOM" id="CLU_009422_4_0_6"/>
    <dbReference type="OMA" id="HRQTDHL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004512">
        <property type="entry name" value="rRNA_MeTrfase_gammaproteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00438">
        <property type="entry name" value="rrmJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000282802" description="Ribosomal RNA large subunit methyltransferase E">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01547"/>
        </source>
    </evidence>
    <sequence length="209" mass="23351" checksum="D43C3A7DEFCAC79A" modified="2005-12-06" version="1">MTGKKRSASSSRWLQEHFSDKYVQQAQKKGLRSRAWFKLDEIQQSDKLFKPGMTVVDLGAAPGGWSQYVVTQIGGKGRIIACDLLPMDPIVGVDFLQGDFRDELVMKALLERVGDSKVQVVMSDMAPNMSGTPAVDIPRAMYLVELALEMCRDVLALGGSFVVKVFQGEGFDEYLREIRSLFTKVKVRKPDSSRARSREVYIVATGRKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BG6</accession>
    <name>RBFA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name type="ordered locus">SDY_3346</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001040205.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404830.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BG6"/>
    <dbReference type="SMR" id="Q32BG6"/>
    <dbReference type="STRING" id="300267.SDY_3346"/>
    <dbReference type="EnsemblBacteria" id="ABB63339">
        <property type="protein sequence ID" value="ABB63339"/>
        <property type="gene ID" value="SDY_3346"/>
    </dbReference>
    <dbReference type="GeneID" id="67414895"/>
    <dbReference type="KEGG" id="sdy:SDY_3346"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4000"/>
    <dbReference type="HOGENOM" id="CLU_089475_5_0_6"/>
    <dbReference type="OMA" id="GDLQHCK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_1000000210" description="Ribosome-binding factor A">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <sequence length="133" mass="15154" checksum="C8EE4FBFD8C01F08" modified="2005-12-06" version="1">MAKEFGRPQRVAQEMQKEIALILQREIKDPRLGMMTTVSGVEMSRDLAYAKVYVTFLNDKDEDAVKAGIKALQEASGFIRSLLGKAMRLRIVPELTFFYDNSLVEGMRMSNLVTSVVKHDEERRVNPDDSKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BH3</accession>
    <name>Q32BH3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhbW</name>
        <name evidence="3" type="ordered locus">SDY_3339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000130370.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404823.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BH3"/>
    <dbReference type="STRING" id="300267.SDY_3339"/>
    <dbReference type="EnsemblBacteria" id="ABB63332">
        <property type="protein sequence ID" value="ABB63332"/>
        <property type="gene ID" value="SDY_3339"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3339"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3993"/>
    <dbReference type="HOGENOM" id="CLU_027853_9_1_6"/>
    <dbReference type="OMA" id="APGSDQM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="335" mass="37198" checksum="DEC23048D4FADD43" modified="2005-12-06" version="1">MTDKTIAFSLLDLAPIPEGSSAREAFSHSLDLARLAEKRGYHRYWLAEHHNMTGIASAATSVLIGYLAANTTTLHLGSGGVMLPNHSPLVIAEQFGTLNTLYPGRIDLGLARAPGSDQRTMMALRRHMIGDIDNFPRDVAELVDWFDARDPNPHVRPVPGYGEKIPVWLLGSSLYSAQLAAQLGLPFAFASHFAPDMLFQALHLYRSNFKPSARLEKPYAMVCINIITADSNRDAEFLFTSMQQAFVKLRRGETGQLPPPIQNMNQFWSPSEQYGVQQALSMSLVGDKAKVRHGLQSILRETDADEIMVNGQIFDHQARLHSFELAMDVKEELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BI6</accession>
    <name>Q32BI6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yraL</name>
        <name evidence="6" type="synonym">rsmI</name>
        <name evidence="8" type="ordered locus">SDY_3325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000809262.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404810.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BI6"/>
    <dbReference type="SMR" id="Q32BI6"/>
    <dbReference type="STRING" id="300267.SDY_3325"/>
    <dbReference type="EnsemblBacteria" id="ABB63319">
        <property type="protein sequence ID" value="ABB63319"/>
        <property type="gene ID" value="SDY_3325"/>
    </dbReference>
    <dbReference type="GeneID" id="58462813"/>
    <dbReference type="KEGG" id="sdy:SDY_3325"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3978"/>
    <dbReference type="HOGENOM" id="CLU_044779_4_0_6"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="286" mass="31348" checksum="886EA492858FB95C" modified="2005-12-06" version="1">MKQHQSADNSQGQLYIVPTPIGNLADITQRALEVLQAVDLIAAEDTRHTGLLLQHFGINARLFALHDHNEQQKAETLLAKLQEGQNIALVSDAGTPLINDPGYHLVRTCREAGIRVVPLPGPCAAITALSAAGLPSDRFCYEGFLPAKSKGRRDALKAIEAEPRTLIFYESTHRLLDSLEDIVAVLGESRYVVLARELTKTWETIHGAPVGELLAWVKEDENRRKGEMVLIVEGHKAQEEDLPADALRTLALLQAELPLKKAAALAAEIHGVKKNALYKYALEQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BK9</accession>
    <name>Q32BK9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yhaL</name>
        <name evidence="1" type="ordered locus">SDY_3299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404787.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BK9"/>
    <dbReference type="EnsemblBacteria" id="ABB63296">
        <property type="protein sequence ID" value="ABB63296"/>
        <property type="gene ID" value="SDY_3299"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3299"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3944"/>
    <dbReference type="HOGENOM" id="CLU_193042_0_0_6"/>
    <dbReference type="OMA" id="ANNFGYE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="55" mass="6066" checksum="1CB3DA848CCDBB58" modified="2005-12-06" version="1">MMSKKSAKKRQPVKPVVAKEPARTAKNFGYEEMLSELEAIVADAETRLAEDEATA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BR1</accession>
    <name>GLNE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP:glutamine synthetase adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATase</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glutamine synthetase adenylyl-L-tyrosine phosphorylase</fullName>
                <ecNumber evidence="1">2.7.7.89</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Adenylyl removase</fullName>
                <shortName evidence="1">AR</shortName>
                <shortName evidence="1">AT-N</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glutamine synthetase adenylyl transferase</fullName>
                <ecNumber evidence="1">2.7.7.42</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Adenylyl transferase</fullName>
                <shortName evidence="1">AT</shortName>
                <shortName evidence="1">AT-C</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">glnE</name>
        <name type="ordered locus">SDY_3236</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP</text>
            <dbReference type="Rhea" id="RHEA:43716"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.7.89"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18589"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GlnE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.89" evidence="1"/>
    <dbReference type="EC" id="2.7.7.42" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378869.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404735.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BR1"/>
    <dbReference type="SMR" id="Q32BR1"/>
    <dbReference type="STRING" id="300267.SDY_3236"/>
    <dbReference type="EnsemblBacteria" id="ABB63244">
        <property type="protein sequence ID" value="ABB63244"/>
        <property type="gene ID" value="SDY_3236"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3236"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3865"/>
    <dbReference type="HOGENOM" id="CLU_006233_0_1_6"/>
    <dbReference type="OMA" id="EFMVQYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047388">
        <property type="term" value="F:[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000820">
        <property type="term" value="P:regulation of glutamine family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00802">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000047016" description="Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme">
        <location>
            <begin position="1"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl removase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl transferase" evidence="1">
        <location>
            <begin position="449"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00802"/>
        </source>
    </evidence>
    <sequence length="946" mass="108516" checksum="3B5CD0D317794C3F" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C14</accession>
    <name>Q32C14_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-specific endonuclease I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">endA</name>
        <name evidence="3" type="ordered locus">SDY_3127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EndA/NucM nuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000286506.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404632.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C14"/>
    <dbReference type="STRING" id="300267.SDY_3127"/>
    <dbReference type="EnsemblBacteria" id="ABB63141">
        <property type="protein sequence ID" value="ABB63141"/>
        <property type="gene ID" value="SDY_3127"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3127"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3737"/>
    <dbReference type="HOGENOM" id="CLU_070541_0_0_6"/>
    <dbReference type="OMA" id="ADQYGQC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007346">
        <property type="entry name" value="Endonuclease-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33607">
        <property type="entry name" value="PTHR33607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04231">
        <property type="entry name" value="Endonuclease_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221022" evidence="2">
        <location>
            <begin position="23"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="235" mass="26673" checksum="7A373F4AC4F80042" modified="2005-12-06" version="1">MYRYLSIAAVVLSAAFSGPALAEGINSFSQAKAAAVKVHADAPGTFYCGCKINWQGKKGVVDLQSCGYQVRKNENRASRVEWEHVVPAWQFGHQRQCWQDGGRKNCAKDPVYRKMESDVHNLQPSVGEVNGDRGNFMYSQWNGGEGQYGQCAVKVDFKEKAAEPPARARGAIARTYFYMRDQYNLTLSRQQTQLFNVWNKMYPVTDWECERDERIAKVQGNHNPYVQRACQARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C37</accession>
    <name>Q32C37_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative secretion pathway protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gspM</name>
        <name evidence="11" type="ordered locus">SDY_3102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP M family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C37"/>
    <dbReference type="STRING" id="300267.SDY_3102"/>
    <dbReference type="EnsemblBacteria" id="ABB63118">
        <property type="protein sequence ID" value="ABB63118"/>
        <property type="gene ID" value="SDY_3102"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3102"/>
    <dbReference type="HOGENOM" id="CLU_118900_3_0_6"/>
    <dbReference type="OMA" id="PQGNKIQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007690">
        <property type="entry name" value="T2SS_GspM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023229">
        <property type="entry name" value="T2SS_M_periplasmic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04612">
        <property type="entry name" value="T2SSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103054">
        <property type="entry name" value="SSF103054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="140" mass="15739" checksum="B3A648FE9D376804" modified="2005-12-06" version="1">MLLAAVVFLFSAGYYVLIWQPLSERIEQQETMLQQLEAMNTRLKNAAPDIIAARKSATTTPAQVSRVISDSASAHSVVIRRIAERGENIQVWIEPVVFNDLLKWLNALDEKYALRVTQIDVSAAEKPVMVNVQRLEFGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C47</accession>
    <name>Q32C47_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative general secretion protein GspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gspC</name>
        <name evidence="9" type="ordered locus">SDY_3092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404599.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C47"/>
    <dbReference type="STRING" id="300267.SDY_3092"/>
    <dbReference type="EnsemblBacteria" id="ABB63108">
        <property type="protein sequence ID" value="ABB63108"/>
        <property type="gene ID" value="SDY_3092"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3092"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3701"/>
    <dbReference type="HOGENOM" id="CLU_068012_2_0_6"/>
    <dbReference type="OMA" id="WRIIPEP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024961">
        <property type="entry name" value="T2SS_GspC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001639">
        <property type="entry name" value="T2SS_protein-GspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11356">
        <property type="entry name" value="T2SSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01713">
        <property type="entry name" value="typeII_sec_gspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01141">
        <property type="entry name" value="T2SP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T2SSC" evidence="8">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="276" mass="30524" checksum="DCE150601F41D9D6" modified="2005-12-06" version="1">MFWLMLLIISAKVAHSLWRYFSFSAEYTVVSPSVNKPPRTDAKTFDKNDVQLISQQNWFGKYQPVAAPVKQPEPAPVAETRLNVVLRGIAFGARPGAVIEEGGKQQVYLQGERPGSHNAVIEEINRDHVMLRYQGKIERLSLAEEERSTVAVTRQKAISDEAKQAVAEPAASAPVELPAAVRQALAKDPQKIFNYIQLTPVHKEGIVGYAVKPGADRALFDASGFKEGDIAIALNQQDFTDPRAMIALMRQLPSMDSIQLTVLRKGARHDISIALR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CD5</accession>
    <name>PYRG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTP synthase</fullName>
            <ecNumber evidence="1">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="1">CTP synthetase</shortName>
            <shortName evidence="1">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrG</name>
        <name type="ordered locus">SDY_2997</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000210878.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404511.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CD5"/>
    <dbReference type="SMR" id="Q32CD5"/>
    <dbReference type="STRING" id="300267.SDY_2997"/>
    <dbReference type="MEROPS" id="C26.964"/>
    <dbReference type="EnsemblBacteria" id="ABB63020">
        <property type="protein sequence ID" value="ABB63020"/>
        <property type="gene ID" value="SDY_2997"/>
    </dbReference>
    <dbReference type="GeneID" id="66673353"/>
    <dbReference type="KEGG" id="sdy:SDY_2997"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3596"/>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_6"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000266218" description="CTP synthase">
        <location>
            <begin position="1"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="291"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="1">
        <location>
            <position position="379"/>
        </location>
    </feature>
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        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
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        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
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        <location>
            <begin position="187"/>
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        <ligand>
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        </ligand>
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            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:46398"/>
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        <location>
            <begin position="239"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="380"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
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        <location>
            <position position="403"/>
        </location>
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            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
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        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <sequence length="545" mass="60374" checksum="FBB9E2E18FA355FC" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CE5</accession>
    <name>Q32CE5_SHIDS</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="5" type="ordered locus">SDY_2987</name>
    </gene>
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        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        <lineage>
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            <taxon>Gammaproteobacteria</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="300267.SDY_1920"/>
    <dbReference type="EnsemblBacteria" id="ABB62026">
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        <property type="gene ID" value="SDY_1920"/>
    </dbReference>
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        <property type="gene ID" value="SDY_2987"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1920"/>
    <dbReference type="KEGG" id="sdy:SDY_2987"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2315"/>
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    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="60"/>
            <end position="87"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11235" checksum="729A052B2BF0C29C" modified="2005-12-06" version="1">MSRKNQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGTLGQWVIAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKATTYFAQESLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CF5</accession>
    <name>Q32CF5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ygcW</name>
        <name evidence="1" type="ordered locus">SDY_2976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404491.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CF5"/>
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    <dbReference type="EnsemblBacteria" id="ABB63000">
        <property type="protein sequence ID" value="ABB63000"/>
        <property type="gene ID" value="SDY_2976"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2976"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3571"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_6"/>
    <dbReference type="OMA" id="QHGKIDN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="261" mass="28120" checksum="E8C69D2525736639" modified="2005-12-06" version="1">MSIESLNAFSMDFFSLKGKTAIVTGGNSGLGQAFAMALAKAGANVFIPSFVKDNGETKEMIENQGVEVDFMQVDITAEGAPQKIIAACCERFGTVDILVNNAGICKLNKVLDFGRADWDPMIDVNLTAAFELSYEAAKIMIPQKSGKIINICSLFSYLGGQWSPAYSATKHALAGFTKAYCDELGQYNIQVNGIAPGYYATDITLATRSNPETNQRVLDHIPANRWGDTQYLMGAAVFLASPASNYVNGHLLVVDGGYLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CF8</accession>
    <name>Q32CF8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ygcS</name>
        <name evidence="9" type="ordered locus">SDY_2973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000971928.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404488.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CF8"/>
    <dbReference type="STRING" id="300267.SDY_2973"/>
    <dbReference type="EnsemblBacteria" id="ABB62997">
        <property type="protein sequence ID" value="ABB62997"/>
        <property type="gene ID" value="SDY_2973"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2973"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3567"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_6"/>
    <dbReference type="OMA" id="QIWIIWL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="44"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="469" mass="50901" checksum="AE9C94D23CF9C21C" modified="2005-12-06" version="1">MMGRCLFGFSGEKPFLLPDNEGVKMNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIGGSALLGLFLGSLVLGWISDHIGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIGLGGDYSVGHTLLTEFSPRRHRGVLLGAFSVVRTVGYVLASIAGHHFISENPEAWRWLLALAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYFGPHVLLGDEVVTATHKHIKTLFSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLLAATLVVMACLPSGSSLTLLLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQVTLLILATVLLVGFVVTWLWAPETKALPLVAAGNVGGANEHSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CM3</accession>
    <name>Q32CM3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucitol-6-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">srlD</name>
        <name evidence="2" type="ordered locus">SDY_2902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001077358.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404423.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CM3"/>
    <dbReference type="SMR" id="Q32CM3"/>
    <dbReference type="STRING" id="300267.SDY_2902"/>
    <dbReference type="EnsemblBacteria" id="ABB62932">
        <property type="protein sequence ID" value="ABB62932"/>
        <property type="gene ID" value="SDY_2902"/>
    </dbReference>
    <dbReference type="GeneID" id="66673426"/>
    <dbReference type="KEGG" id="sdy:SDY_2902"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3487"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_6"/>
    <dbReference type="OMA" id="QGIHFQN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="259" mass="27858" checksum="29C6215F857B5FBC" modified="2005-12-06" version="1">MNQVAVVIGGGQTLGAFLCHGLAAEGYRVAVVDIQSDKAANVAQEINAEYGESMAYGFGADATSEQSVLALSRGVDEIFGRVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCAREFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGCDYQDVLNMLLFYASPKASYCTGQSINVTGGQVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CP5</accession>
    <name>Q32CP5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High-affinity transport system for glycine betaine and proline</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">proW</name>
        <name evidence="9" type="ordered locus">SDY_2873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000774982.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404401.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CP5"/>
    <dbReference type="STRING" id="300267.SDY_2873"/>
    <dbReference type="EnsemblBacteria" id="ABB62910">
        <property type="protein sequence ID" value="ABB62910"/>
        <property type="gene ID" value="SDY_2873"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2873"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3452"/>
    <dbReference type="HOGENOM" id="CLU_028473_2_0_6"/>
    <dbReference type="OMA" id="HFNIMDP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="145"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="354" mass="37634" checksum="2EA4E923B0A9197B" modified="2005-12-06" version="1">MADQNNPWDTTPAADSAAQSADAWGTPATAPTDGGGADWLTSTPAPNVEHFNILDPFHKTLIPLDSWVTEGIDWVVTHFRPVFQGVRVPVDYILNGFQQLLLSMPAPVAIIVFALIAWQISGVGMGVATLVSLIAIGAIGAWSQAMVTLPLVLTALLFCIVIGLPLGIWLARSPRAAKIIRPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTITFALPPIIRLTILGINQVPADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVGGLGQMVLRGIGRLDMGLATVGGVGIVILAIILDRLTQAVGRDSRSRGNRRWYTTGPVGLLTRPFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CS2</accession>
    <name>Q32CS2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CS2"/>
    <dbReference type="STRING" id="300267.SDY_2844"/>
    <dbReference type="EnsemblBacteria" id="ABB62883">
        <property type="protein sequence ID" value="ABB62883"/>
        <property type="gene ID" value="SDY_2844"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2844"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_11_6"/>
    <dbReference type="OMA" id="WVSHEHI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="106"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="203" mass="22911" checksum="A272572BC7061363" modified="2005-12-06" version="1">MVTLCHVFGVHRSSYRYWKNRPEKPDGRRAVLRSQVLELHGISHGSAGARSIATMATRRGYQMGRWLAGRLMKELGLVSCQQPTHRYKRGGHEHVAIPNYLERQFAVTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKPGGVMFHSDQGSQTSISPEKAGLRPPPGCYLPPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CW6</accession>
    <name>Q32CW6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CW6"/>
    <dbReference type="EnsemblBacteria" id="ABB62839">
        <property type="protein sequence ID" value="ABB62839"/>
        <property type="gene ID" value="SDY_2796"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2796"/>
    <dbReference type="HOGENOM" id="CLU_2221441_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="95" mass="10829" checksum="0CCDE2F2ADCA30F4" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITLFLIYLAQGELHLTPYAVAEFQIPVQPPCGNQEYRALFWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D66</accession>
    <name>Q32D66_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exopolyphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ppx</name>
        <name evidence="8" type="ordered locus">SDY_2691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21528"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14279"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GppA/Ppx family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001121358.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404230.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D66"/>
    <dbReference type="STRING" id="300267.SDY_2691"/>
    <dbReference type="EnsemblBacteria" id="ABB62739">
        <property type="protein sequence ID" value="ABB62739"/>
        <property type="gene ID" value="SDY_2691"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2691"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3246"/>
    <dbReference type="HOGENOM" id="CLU_025908_4_0_6"/>
    <dbReference type="OMA" id="RISEGCY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006793">
        <property type="term" value="P:phosphorus metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022371">
        <property type="entry name" value="Exopolyphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030673">
        <property type="entry name" value="PyroPPase_GppA_Ppx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001267">
        <property type="entry name" value="Pyrophosphatase_GppA_Ppx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03706">
        <property type="entry name" value="exo_poly_only"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="7">
        <location>
            <begin position="26"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="513" mass="58118" checksum="4553527E98DFE886" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D72</accession>
    <name>HDA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaA regulatory inactivator Hda</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hda</name>
        <name type="ordered locus">SDY_2685</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The active form seems to be an ADP-bound monomer. Forms the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DnaA family. HdA subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62733" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62733.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404224.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D72"/>
    <dbReference type="SMR" id="Q32D72"/>
    <dbReference type="STRING" id="300267.SDY_2685"/>
    <dbReference type="EnsemblBacteria" id="ABB62733">
        <property type="protein sequence ID" value="ABB62733"/>
        <property type="gene ID" value="SDY_2685"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2685"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3239"/>
    <dbReference type="HOGENOM" id="CLU_072265_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032297">
        <property type="term" value="P:negative regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01158">
        <property type="entry name" value="Hda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017788">
        <property type="entry name" value="Hda"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022864">
        <property type="entry name" value="Hda_Enterobact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03420">
        <property type="entry name" value="DnaA_homol_Hda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0236">DNA replication inhibitor</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000065567" description="DnaA regulatory inactivator Hda">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="233" mass="26633" checksum="D25C7CDF31DAF7DC" modified="2009-11-24" version="2">MNTPAQLSLPLYLPDDETFASFWPGDNSSLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEHLSLVCIDNIECIAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASITAQRKLTIPFVKEILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DA9</accession>
    <name>Q32DA9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2360</name>
        <name evidence="4" type="ordered locus">SDY_2643</name>
        <name evidence="5" type="ordered locus">SDY_2693</name>
        <name evidence="6" type="ordered locus">SDY_3639</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_2360"/>
    <dbReference type="EnsemblBacteria" id="ABB62437">
        <property type="protein sequence ID" value="ABB62437"/>
        <property type="gene ID" value="SDY_2360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62696">
        <property type="protein sequence ID" value="ABB62696"/>
        <property type="gene ID" value="SDY_2643"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62740">
        <property type="protein sequence ID" value="ABB62740"/>
        <property type="gene ID" value="SDY_2693"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63607">
        <property type="protein sequence ID" value="ABB63607"/>
        <property type="gene ID" value="SDY_3639"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2360"/>
    <dbReference type="KEGG" id="sdy:SDY_2643"/>
    <dbReference type="KEGG" id="sdy:SDY_2693"/>
    <dbReference type="KEGG" id="sdy:SDY_3639"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="145" mass="16823" checksum="A0FB43905DC34FB0" modified="2005-12-06" version="1">MPKRITSSPVAHADVALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DB6</accession>
    <name>Q32DB6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ARAC-type regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yfeG</name>
        <name evidence="3" type="ordered locus">SDY_2635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000753735.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404180.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DB6"/>
    <dbReference type="STRING" id="300267.SDY_2635"/>
    <dbReference type="EnsemblBacteria" id="ABB62689">
        <property type="protein sequence ID" value="ABB62689"/>
        <property type="gene ID" value="SDY_2635"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2635"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3173"/>
    <dbReference type="HOGENOM" id="CLU_047930_2_0_6"/>
    <dbReference type="OMA" id="FLHHPER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="243"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="350" mass="40101" checksum="28C84598E2F5788A" modified="2005-12-06" version="1">MKKTRTANVHHLYHEPLPENLKLTPKVEVDNVHQRQTTDVYEHALTITAWQQIYDQLHPGKFHGEFTEILLDDIQVFREYTGLALRQSCLVWPNSFWFGIPATRGEQGFIGSQCLGSAEIATRPGGTEFELSTPDDYTILGVVLSEDVITRQANFLHNPDRVLHMLRSQSALEVKEQHKAALWGFVQQALATFCENPENLHQPAVRKVLGDNLLMAMGAMLEEAQPMVTVESISHQSYRRLLSRAREYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELISPWSQSTTVKDAAMQWGFWHLGQFATDYQQLFAEKPSLTLHQRMREWG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DC5</accession>
    <name>PTYBC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PTS system N-acetylmuramic acid-specific EIIBC component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">EIIBC-MurNAc</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="1">N-acetylmuramic acid-specific phosphotransferase enzyme IIB component</fullName>
                <ecNumber evidence="1">2.7.1.192</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">PTS system N-acetylmuramic acid-specific EIIB component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">N-acetylmuramic acid permease IIC component</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">PTS system N-acetylmuramic acid-specific EIIC component</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name type="primary">murP</name>
        <name type="ordered locus">SDY_2625</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) = L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:33399"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58721"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="ChEBI" id="CHEBI:64848"/>
            <dbReference type="EC" id="2.7.1.192"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.192" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001040498.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404171.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DC5"/>
    <dbReference type="SMR" id="Q32DC5"/>
    <dbReference type="STRING" id="300267.SDY_2625"/>
    <dbReference type="EnsemblBacteria" id="ABB62680">
        <property type="protein sequence ID" value="ABB62680"/>
        <property type="gene ID" value="SDY_2625"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2625"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3162"/>
    <dbReference type="HOGENOM" id="CLU_012312_2_0_6"/>
    <dbReference type="OMA" id="VAHCMTR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0598">Phosphotransferase system</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000248959" description="PTS system N-acetylmuramic acid-specific EIIBC component">
        <location>
            <begin position="1"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="390"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="4">
        <location>
            <begin position="115"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="3">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P77272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00426"/>
        </source>
    </evidence>
    <sequence length="474" mass="49812" checksum="44F99A26507D3001" modified="2005-12-06" version="1">MAKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPNIKTLEGVKGVILTSDQVQVVFGPGKAHRATKAMSELLGEAPVQDAAEIAAQNKRQLKAKQTSGVQQFLAKFATIFTPLIPGFIAAGLLLGIATLIATVMHVPADAQGTLPDALNFMKVFSKGLFTFLVILVGYNAAQAFGGTGVNGAIIAALFLLGYNPAATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACARIEGMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPLGCAVLAGLFLIAVVFGVHQGFIPVYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPHSGLRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFITACLGGAAGGLFIGLIAWWGLPMGLNSAFGPSGLVALPLMTSAQGILPAMAIYAGGILVAWVCGFIFTTLFGCRNVNLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DL2</accession>
    <name>MNMC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC</fullName>
            <shortName evidence="1">tRNA mnm(5)s(2)U biosynthesis bifunctional protein</shortName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">tRNA (mnm(5)s(2)U34)-methyltransferase</fullName>
                <ecNumber evidence="1">2.1.1.61</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">FAD-dependent cmnm(5)s(2)U34 oxidoreductase</fullName>
                <ecNumber evidence="1">1.5.-.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmC</name>
        <name type="ordered locus">SDY_2523</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19569"/>
            <dbReference type="Rhea" id="RHEA-COMP:10195"/>
            <dbReference type="Rhea" id="RHEA-COMP:10197"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74454"/>
            <dbReference type="ChEBI" id="CHEBI:74455"/>
            <dbReference type="EC" id="2.1.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the DAO family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62593" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.1.1.61" evidence="1"/>
    <dbReference type="EC" id="1.5.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62593.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000683778.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404084.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DL2"/>
    <dbReference type="SMR" id="Q32DL2"/>
    <dbReference type="STRING" id="300267.SDY_2523"/>
    <dbReference type="EnsemblBacteria" id="ABB62593">
        <property type="protein sequence ID" value="ABB62593"/>
        <property type="gene ID" value="SDY_2523"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2523"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3038"/>
    <dbReference type="HOGENOM" id="CLU_022427_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016645">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004808">
        <property type="term" value="F:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002097">
        <property type="term" value="P:tRNA wobble base modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01102">
        <property type="entry name" value="MnmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008471">
        <property type="entry name" value="MnmC-like_methylTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023032">
        <property type="entry name" value="tRNA_MAMT_biosynth_bifunc_MnmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017610">
        <property type="entry name" value="tRNA_S-uridine_synth_MnmC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05430">
        <property type="entry name" value="Methyltransf_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03197">
        <property type="entry name" value="MnmC_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000348041" description="tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC">
        <location>
            <begin position="1"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="tRNA (mnm(5)s(2)U34)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="FAD-dependent cmnm(5)s(2)U34 oxidoreductase">
        <location>
            <begin position="270"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="668" mass="74778" checksum="D58BF7D40912AF34" modified="2008-09-02" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DL7</accession>
    <name>Q32DL7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PTS system enzyme II A component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">usg</name>
        <name evidence="2" type="ordered locus">SDY_2518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001289175.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404079.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DL7"/>
    <dbReference type="STRING" id="300267.SDY_2518"/>
    <dbReference type="EnsemblBacteria" id="ABB62588">
        <property type="protein sequence ID" value="ABB62588"/>
        <property type="gene ID" value="SDY_2518"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2518"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3033"/>
    <dbReference type="HOGENOM" id="CLU_049966_0_1_6"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="337" mass="36392" checksum="858F4B287760B560" modified="2005-12-06" version="1">MSEGWNIAVLGATGAVGEALLETLAERQFPVGEIYALARNESAGEQLRFGGKTITVQDAAEFDWTQAQLAFFVAGKEATAAWVEEATNSGCLVIDSSGLFVLEPDVPLVVPEVNPFVLTDYRNRNVIAVPDSLTSQLLAALKPLIDQGGLSRISVTSLISASAQGKKAVDALAGQSAKLLNGIPIDEEDFFGRQLAFNMLPLLPDSEGSVREERRIVDEVRKILQDEGLMISASVVQAPVFYGHAQMVNFEALRPLAAEEARDAFVQGEDIVLSEENEFPTQVGDASGTPHLSVGCVRNDYGMPEQVQFWSVADNVRFGGALMAVKIAEKLVQEYLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-01-20" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DM0</accession>
    <name>ACCD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
            <shortName evidence="1">ACCase subunit beta</shortName>
            <shortName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            <ecNumber evidence="1">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">accD</name>
        <name type="ordered locus">SDY_2515</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000118396.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404076.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DM0"/>
    <dbReference type="SMR" id="Q32DM0"/>
    <dbReference type="STRING" id="300267.SDY_2515"/>
    <dbReference type="EnsemblBacteria" id="ABB62585">
        <property type="protein sequence ID" value="ABB62585"/>
        <property type="gene ID" value="SDY_2515"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2515"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3030"/>
    <dbReference type="HOGENOM" id="CLU_015486_1_0_6"/>
    <dbReference type="OMA" id="PEGLWIK"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041010">
        <property type="entry name" value="Znf-ACC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17848">
        <property type="entry name" value="zf-ACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000359065" description="Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="304" mass="33338" checksum="504FAC94D734EFCB" modified="2005-12-06" version="1">MSWIERIKSNITPTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMTARNRLHSLLDEGSLVELGSELEPKDVLKFRDSKKYKDRLASAQKETGEKDALVVMKGTLYGMPVVAAAFEFAFMGGSMGSVVGARFVRAVEQALEDNCPLICFSASGGARMQEALMSLMQMAKTSAALAKMQERGLPYISVLTDPTMGGVSASFAMLGDLNIAEPKALIGFAGPRVIEQTVREKLPLGFQRSEFLIEKGAIDMIVRRPEMRLKLASILAKLMNLPAPNPEAPREGVVVPPVPDQEPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DS8</accession>
    <name>Q32DS8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-succinylbenzoate--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">o-succinylbenzoyl-CoA synthetase</fullName>
            <shortName evidence="3">OSB-CoA synthetase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">menE</name>
        <name evidence="6" type="ordered locus">SDY_2456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17009"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.26" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000577578.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404018.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DS8"/>
    <dbReference type="STRING" id="300267.SDY_2456"/>
    <dbReference type="EnsemblBacteria" id="ABB62527">
        <property type="protein sequence ID" value="ABB62527"/>
        <property type="gene ID" value="SDY_2456"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2456"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2963"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_6"/>
    <dbReference type="OMA" id="YHVSGLM"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008756">
        <property type="term" value="F:o-succinylbenzoate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00731">
        <property type="entry name" value="MenE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010192">
        <property type="entry name" value="MenE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01923">
        <property type="entry name" value="menE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="5">
        <location>
            <begin position="366"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="451" mass="50229" checksum="603DD2615FD120CE" modified="2005-12-06" version="1">MIFSDWPWRHWRQVRGEAIALRLNDEQLNWRELCARVDELASGFAVQGVVEGSGVMLRAWNTPQTLLAWLALLQCGARVLPVNPQLPQPLLEELLPNLTLQFALVPDGENTFPALTSLHIQRVEGAHAATWQPTRLCSMTLTSGSTGLPKAAVHTYQAHLASAEGVLSLIPFGDHDDWLLSLPLFHVSGQGIMWRWLYAGARMTVRDKQPLEQMLAGCTHASLVPTQLWRLLVNRSSVSLKAVLLGGAAIPVELTEQAREQGIRCFCGYGLTEFASTVCAKEADGLADVGSPLPGREVKIVNNEVWLRAASMAEGYWRNGQLVSLVNDEGWYTTRDRGEMHNGKLTIVGRLDNLFFSGGEGIQPEEVERVIAAHPAVLQVFIVPVADKEFGHRPVAVMEYDHESVDLSEWVKDKLARFQQPVRWLTLPPELKNGGIKISRQALKEWVQRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E22</accession>
    <name>Q32E22_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycaO</name>
        <name evidence="2" type="ordered locus">SDY_2356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E22"/>
    <dbReference type="STRING" id="300267.SDY_2356"/>
    <dbReference type="EnsemblBacteria" id="ABB62433">
        <property type="protein sequence ID" value="ABB62433"/>
        <property type="gene ID" value="SDY_2356"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2356"/>
    <dbReference type="HOGENOM" id="CLU_022530_1_0_6"/>
    <dbReference type="OMA" id="FRRMFGN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041080">
        <property type="entry name" value="YcaO_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18381">
        <property type="entry name" value="YcaO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00702">
        <property type="entry name" value="TIGR00702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="547" mass="61292" checksum="3B6201CA2BE32677" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EA7</accession>
    <name>Q32EA7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative nucleoside permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yegT</name>
        <name evidence="8" type="ordered locus">SDY_2271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000858507.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403839.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EA7"/>
    <dbReference type="STRING" id="300267.SDY_2271"/>
    <dbReference type="EnsemblBacteria" id="ABB62348">
        <property type="protein sequence ID" value="ABB62348"/>
        <property type="gene ID" value="SDY_2271"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2271"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2744"/>
    <dbReference type="HOGENOM" id="CLU_013133_1_2_6"/>
    <dbReference type="OMA" id="GQIGMAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004740">
        <property type="entry name" value="Nuc_H_symport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03825">
        <property type="entry name" value="Nuc_H_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00889">
        <property type="entry name" value="2A0110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="194"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="425" mass="47405" checksum="E9E5E7E9C86D7109" modified="2005-12-06" version="1">MKTTAKLSFMMFVEWFIWGAWFVPLWLWLSKSGFSAGEIGWSYACTAIAAILSPILVGSITDRFFSAQKVLAVLMFAGALLMYFAVQQTTFAGFFPLLLAYSLTYMPTIALTNSIAFANVPDVERDFPRIRVMGTIGWIASGLACGFLPQMLGYADISPTNIPLLITAGSSALLGVFAFFLPDTPPKSTGKMDIKVMLGLDALILLRDKNFLVFFFCSFLFAMPLAFYYIFANGYLTEVGMKNATGWMTLGQFSEIFFMLALPFFTKRFGVKKVLLLGLVTAAIRYGFFIYGSADEYFTYALLFLGILLHGVSYEFYYVTAYIYVDKKAPVHMRTAAQGLITLCCQGFGSLLGYRLGGVMMEKMFAYQEPVNGLTFNWSGMWTFGAVMIAIIAVLFMIFFRESDNEITAIKVDDRDIALTQGEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EG6</accession>
    <name>Q32EG6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbB</name>
        <name evidence="7" type="ordered locus">SDY_2204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000699445.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403780.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EG6"/>
    <dbReference type="STRING" id="300267.SDY_2204"/>
    <dbReference type="EnsemblBacteria" id="ABB62289">
        <property type="protein sequence ID" value="ABB62289"/>
        <property type="gene ID" value="SDY_2204"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2204"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2667"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_6"/>
    <dbReference type="OMA" id="EWCQHVQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="4"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="361" mass="40512" checksum="8DACCF2A1BE9D611" modified="2005-12-06" version="1">MKILVTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNLESLADVSDSKRYVFEHADICDAAAMARIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARNYWSALDGDKKNSFRFHHISTDEVYGDLPHPDEVNNKEQLPLFTETTAYAPSSPYSASKASSDHLVRAWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYVEDHARALYIVVTEGKAGETYNIGGHNEKKNIDVVLTICDLLDEIVPKEKSYREQITYVADRPGHDRRYAIDAEKISRELGWKPQETFESGIRKTVGWYLSNTKWVDNVKSGAYQSWIEQNYEGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EG7</accession>
    <name>Q32EG7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-D-glucosyl-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine diphosphoglucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">galF</name>
        <name evidence="11" type="ordered locus">SDY_2203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; nucleotide-sugar metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000183052.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403779.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EG7"/>
    <dbReference type="STRING" id="300267.SDY_2203"/>
    <dbReference type="EnsemblBacteria" id="ABB62288">
        <property type="protein sequence ID" value="ABB62288"/>
        <property type="gene ID" value="SDY_2203"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2203"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2665"/>
    <dbReference type="HOGENOM" id="CLU_029499_1_1_6"/>
    <dbReference type="OMA" id="MHYVRQG"/>
    <dbReference type="UniPathway" id="UPA00215"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005774">
        <property type="entry name" value="GalF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01105">
        <property type="entry name" value="galF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="297" mass="32845" checksum="0385D6AB4280D5F8" modified="2005-12-06" version="1">MTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIVDEIVAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVTIMNVRQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGRSQVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGRYVLSADIWPELERTQLGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVKYGLRNLKEGAKFRKGIEKLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EK9</accession>
    <name>Q32EK9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yehW</name>
        <name evidence="8" type="ordered locus">SDY_2160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000783124.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403737.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EK9"/>
    <dbReference type="STRING" id="300267.SDY_2160"/>
    <dbReference type="EnsemblBacteria" id="ABB62246">
        <property type="protein sequence ID" value="ABB62246"/>
        <property type="gene ID" value="SDY_2160"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2160"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2612"/>
    <dbReference type="HOGENOM" id="CLU_046113_7_0_6"/>
    <dbReference type="OMA" id="TAYVLQG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="50"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="243" mass="25484" checksum="E1BAFB066FCEF1E1" modified="2005-12-06" version="1">MKMLRDPLFWLIALFVALIFWLPYSQPLFAALFPQLPRPVYQQESFAALALAHFWLVGISSLFAVIIGTGAGIAVTRPWGAEFRPLVETIAAVGQTFPPVAVLAIAVPVIGFGLQPAIIALILYGVLPVLQATLAGLGAIDASVTVVAKGMGMSRGQRLRKVELPLAAPVILAGVRTSVIINIGTATVASTVGASTLGTPIIIGLSGFNTAYVIQGALLVALAAIIANRLFERLVQALSQHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EN7</accession>
    <name>Q32EN7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF418 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yeiB</name>
        <name evidence="3" type="ordered locus">SDY_2128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EN7"/>
    <dbReference type="STRING" id="300267.SDY_2128"/>
    <dbReference type="EnsemblBacteria" id="ABB62218">
        <property type="protein sequence ID" value="ABB62218"/>
        <property type="gene ID" value="SDY_2128"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2128"/>
    <dbReference type="HOGENOM" id="CLU_039610_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007349">
        <property type="entry name" value="DUF418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04235">
        <property type="entry name" value="DUF418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="DUF418" evidence="2">
        <location>
            <begin position="215"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="308" mass="34397" checksum="9392E34D0C1E93B7" modified="2005-12-06" version="1">MERNVTLDFVRGVAILGILLLNISAFGLPKAAYLNPAWYGAITPQDAWTWAFLDLIGQVKFLTLFALLFGAGLQMLLPRGRRWIQSRLTLLVLLGFIHGLLFWDGDILLAYGLVGLICWRLVRDAPSVKSLFNTGVMLYLVGLGVLLLLGLISDSQTSRAWTPDASAILYEKYWKLHGGVEAISNRADGVGNSLLALGAQYGWQLAGMMLIGAALMRSGWLKGQFRLRHYRRTGFVLVAIGVTINLPAIALQWQLDWAYRWCAFLLQMPRELSAPFQAIGYASLFYGFWPQLSRFKLGLRSPASDGWR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EW7</accession>
    <name>NAGZ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-hexosaminidase</fullName>
            <ecNumber evidence="1">3.2.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-beta-glucosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nagZ</name>
        <name type="ordered locus">SDY_2043</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000529291.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403629.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EW7"/>
    <dbReference type="SMR" id="Q32EW7"/>
    <dbReference type="STRING" id="300267.SDY_2043"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62138">
        <property type="protein sequence ID" value="ABB62138"/>
        <property type="gene ID" value="SDY_2043"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2043"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2457"/>
    <dbReference type="HOGENOM" id="CLU_008392_0_0_6"/>
    <dbReference type="OMA" id="WQMAAEM"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00364">
        <property type="entry name" value="NagZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022956">
        <property type="entry name" value="Beta_hexosaminidase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000234924" description="Beta-hexosaminidase">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00364"/>
        </source>
    </evidence>
    <sequence length="341" mass="37577" checksum="71E29EF5B2FA536B" modified="2005-12-06" version="1">MGPVMLDVEGYELDAEEREILAHPLVGGLILFTRNYHDPAQLRELVRQIRAASRNHLVVAVDQEGGRVQRFREGFTRLPAAQSFAALLGMEEGGKLAQEAGWLMASEMIAMDIDISFAPVLDVGHISAAIGERSYHADPEKALAIASRFIDGMHEAGMKTTGKHFPGHGAVTADSHKETPCDPRPQAEIRAKDMSVFSTLIRENKLDAIMPAHVIYSDVDPRPASGSSYWLKTVLRQELGFDGVIFSDDLSMEGAAIMGSYAERGQASLDAGCDMILVCNNRKGAVSVLDNLSPIKAERVTRLYHKGSFSRQELMDSARWKAISARLNQLHERWQEEKAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EW9</accession>
    <name>Q32EW9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Respiratory NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndh</name>
        <name evidence="3" type="ordered locus">SDY_2041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378770.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403627.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EW9"/>
    <dbReference type="STRING" id="300267.SDY_2041"/>
    <dbReference type="EnsemblBacteria" id="ABB62136">
        <property type="protein sequence ID" value="ABB62136"/>
        <property type="gene ID" value="SDY_2041"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2041"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2455"/>
    <dbReference type="HOGENOM" id="CLU_021377_7_0_6"/>
    <dbReference type="OMA" id="DHCIFLD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="434" mass="47340" checksum="352D5A40E31E0501" modified="2005-12-06" version="1">MTTPLKKIVIVGGGAGGLEMATQLGHKLGRKKKAKITLVDRNHSHLWKPLLHEVATGSLDEGVDALSYLAHARNHGFQFQLGSVIDIDREAKTITIAELRDEKGELLVPERKIAYDTLVMALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLKYSANLGANGKVNIAIVGGGATGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISAAAHNELTKLGVRVLTQTMVTSADEGGLHTKDGEYIEADLMVWAAGIKAPDFLKDIGGLETNRINQLVVEPTLQTTHDPDIYAIGDCASCPRPEGGFVPPRAQAAHQMATCAMNNILAQMNGKPLKNYQYKDHGSLVSLSNFSTVGSLMGNLTRGSMMIEGRIARFVYISLYRMHQIALHGYFKTGLMMLVGSINRVIRPRLKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F49</accession>
    <name>Q32F49_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F49"/>
    <dbReference type="EnsemblBacteria" id="ABB62056">
        <property type="protein sequence ID" value="ABB62056"/>
        <property type="gene ID" value="SDY_1955"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1955"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7442" checksum="C63CEF45D8B326E0" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITLYLYPVNKPTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FC6</accession>
    <name>Q32FC6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Superoxide dismutase (Cu-Zn)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sodC</name>
        <name evidence="6" type="ordered locus">SDY_1870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022308.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403470.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FC6"/>
    <dbReference type="SMR" id="Q32FC6"/>
    <dbReference type="STRING" id="300267.SDY_1870"/>
    <dbReference type="EnsemblBacteria" id="ABB61979">
        <property type="protein sequence ID" value="ABB61979"/>
        <property type="gene ID" value="SDY_1870"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1870"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2249"/>
    <dbReference type="HOGENOM" id="CLU_056632_7_1_6"/>
    <dbReference type="OMA" id="EHGFNNP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="PTHR10003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220822" evidence="4">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Cu" evidence="5">
        <location>
            <begin position="39"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="173" mass="17661" checksum="420CB65F03AABCEF" modified="2005-12-06" version="1">MKRFSLAILALVVATGAQAASEKVEMNLVTSQGVGQSIGSVTITETDKGLEFSPDLKALPPGEHGFHIHAKGSCQPATKDGKASAAESAGGHLDPQNTGKHEGPEGAGHLGDLPALVVNNDGKATDAVIAPRLKSLDEIKDKALMVHVGGNNMSDQPKPLGGGGEHYACGVIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FE1</accession>
    <name>RSXE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ion-translocating oxidoreductase complex subunit E</fullName>
            <ecNumber evidence="1">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Rsx electron transport complex subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsxE</name>
        <name type="ordered locus">SDY_1855</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001289652.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403455.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FE1"/>
    <dbReference type="SMR" id="Q32FE1"/>
    <dbReference type="STRING" id="300267.SDY_1855"/>
    <dbReference type="EnsemblBacteria" id="ABB61964">
        <property type="protein sequence ID" value="ABB61964"/>
        <property type="gene ID" value="SDY_1855"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1855"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2234"/>
    <dbReference type="HOGENOM" id="CLU_046659_1_0_6"/>
    <dbReference type="OMA" id="DGFMMGL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00478">
        <property type="entry name" value="RsxE_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010968">
        <property type="entry name" value="RnfE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30586:SF0">
        <property type="entry name" value="PTHR30586:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01948">
        <property type="entry name" value="rnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000014110" description="Ion-translocating oxidoreductase complex subunit E">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00478"/>
        </source>
    </evidence>
    <sequence length="231" mass="24459" checksum="CFA37A2D292604C3" modified="2005-12-06" version="1">MSEIKDVIVQGLWKNNSALVQLLGLCPLLAVTSTATNALGLGLATTLVLTLTNLTISTLRHWTPAEIRIPIYVMIIASVVSAVQMLINAYAFGLYQSLGIFIPLIVTNCIVVGRAEAFAAKKGPALSALDGFSIGMGATCAMFVLGSLREIIGNGTLFDGADALLGSWAKVLRVEIFHTDSPFLLAMLPPGAFIGLGLMLAGKYLIDERMKKRRAEAAAERALPNGETGNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FI0</accession>
    <name>SYT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="1">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrS</name>
        <name type="ordered locus">SDY_1814</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001144210.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403416.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FI0"/>
    <dbReference type="SMR" id="Q32FI0"/>
    <dbReference type="STRING" id="300267.SDY_1814"/>
    <dbReference type="EnsemblBacteria" id="ABB61925">
        <property type="protein sequence ID" value="ABB61925"/>
        <property type="gene ID" value="SDY_1814"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1814"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2185"/>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_6"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000020512" description="Threonine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="1">
        <location>
            <begin position="243"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01228"/>
        </source>
    </evidence>
    <sequence length="642" mass="74044" checksum="9D273B8CA810A7BA" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FJ1</accession>
    <name>Q32FJ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nlpC</name>
        <name evidence="4" type="ordered locus">SDY_1803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001209787.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403405.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FJ1"/>
    <dbReference type="STRING" id="300267.SDY_1803"/>
    <dbReference type="MEROPS" id="C40.A01"/>
    <dbReference type="EnsemblBacteria" id="ABB61914">
        <property type="protein sequence ID" value="ABB61914"/>
        <property type="gene ID" value="SDY_1803"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1803"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2175"/>
    <dbReference type="HOGENOM" id="CLU_016043_9_3_6"/>
    <dbReference type="OMA" id="WKRAYWQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220956" evidence="2">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="32"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="154" mass="17308" checksum="2FD27CDFE44B145F" modified="2005-12-06" version="1">MRFCLILITALFLAGCSHHKAPSPNARLSDSITVIAGLNDQLQSWHGTPYRYGGMTRRGVDCSGFVVVTMRDRFDLQLPRETKEQASIGTQIDKDELLPGDLVFFKTGSGQNGLHVGIYDTNNQFIHASTSKGVMRSSLDNVYWQKNFWQARRI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FN2</accession>
    <name>OPGD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucans biosynthesis protein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mdoD</name>
        <name evidence="1" type="synonym">opgD</name>
        <name type="ordered locus">SDY_1756</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; osmoregulated periplasmic glucan (OPG) biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text>Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OpgD/OpgG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000375932.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403364.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FN2"/>
    <dbReference type="SMR" id="Q32FN2"/>
    <dbReference type="STRING" id="300267.SDY_1756"/>
    <dbReference type="EnsemblBacteria" id="ABB61873">
        <property type="protein sequence ID" value="ABB61873"/>
        <property type="gene ID" value="SDY_1756"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1756"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2115"/>
    <dbReference type="HOGENOM" id="CLU_023403_2_0_6"/>
    <dbReference type="OMA" id="DVQFFHV"/>
    <dbReference type="UniPathway" id="UPA00637"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01068">
        <property type="entry name" value="MdoD_OpgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023724">
        <property type="entry name" value="Glucan_biosyn_MdoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014438">
        <property type="entry name" value="Glucan_biosyn_MdoG/MdoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007444">
        <property type="entry name" value="Glucan_biosyn_MdoG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30504">
        <property type="entry name" value="PTHR30504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04349">
        <property type="entry name" value="MdoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006281">
        <property type="entry name" value="MdoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" description="Tat-type signal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_1000064553" description="Glucans biosynthesis protein D">
        <location>
            <begin position="33"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01068"/>
        </source>
    </evidence>
    <sequence length="551" mass="62748" checksum="7FC2F0769CB2EA3E" modified="2005-12-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FQ1</accession>
    <name>Q32FQ1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403345.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FQ1"/>
    <dbReference type="SMR" id="Q32FQ1"/>
    <dbReference type="STRING" id="300267.SDY_1736"/>
    <dbReference type="EnsemblBacteria" id="ABB61854">
        <property type="protein sequence ID" value="ABB61854"/>
        <property type="gene ID" value="SDY_1736"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1736"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2094"/>
    <dbReference type="HOGENOM" id="CLU_140890_2_0_6"/>
    <dbReference type="OMA" id="AFEFYFE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="145" mass="16106" checksum="4F2FA9194AB0F92D" modified="2005-12-06" version="1">MRETVEIMRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKVLLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FS7</accession>
    <name>Q32FS7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease D</fullName>
            <shortName evidence="4">RNase D</shortName>
            <ecNumber evidence="4">3.1.13.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rnd</name>
        <name evidence="6" type="ordered locus">SDY_1708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides.</text>
            <dbReference type="EC" id="3.1.13.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.5" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403319.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FS7"/>
    <dbReference type="STRING" id="300267.SDY_1708"/>
    <dbReference type="EnsemblBacteria" id="ABB61828">
        <property type="protein sequence ID" value="ABB61828"/>
        <property type="gene ID" value="SDY_1708"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1708"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2062"/>
    <dbReference type="HOGENOM" id="CLU_042387_0_1_6"/>
    <dbReference type="OMA" id="FMRVDTF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033890">
        <property type="term" value="F:ribonuclease D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042780">
        <property type="term" value="P:tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01899">
        <property type="entry name" value="RNase_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006292">
        <property type="entry name" value="RNase_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01388">
        <property type="entry name" value="rnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="5">
        <location>
            <begin position="210"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="375" mass="42772" checksum="E1D8DE5ABD7CEA80" modified="2005-12-06" version="1">MHYQMITTDDALASLCEAVRAFPAIALDTEFVRTRTYYPQLGLIQLFDGEHLALIDPLGITDWSPLKAILRDPSITKFLHAGSEDLEVFLNVFGELPQPLIDTQILAAFCGRPMSWGFASMVEEYSGVTLDKSESRTDWLARPLTERQCEYAAADVWYLLPITAKLMVETEASGWLPAALDECRLMQMRRQEVVAPEDAWRDITNAWQLRTRQLACLQLLADWRLRKARERNLAVNFVVREEHLWSVARYMPGSLGELDSLGLSGSEIRFHGKTLLALVEKAQTLPEDALPQPMLNLMDMPGYRKAFKAIKSLITDVSETHKISAELLASRRQINQLLNWHWKLKPQNNLPELISGWRGELMAEALHNLLQEYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FS8</accession>
    <name>Q32FS8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carnitine monooxygenase reductase subunit</fullName>
            <ecNumber evidence="6">1.14.13.239</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Carnitine monooxygenase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yeaX</name>
        <name evidence="9" type="ordered locus">SDY_1707</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Converts carnitine to trimethylamine and malic semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine</text>
            <dbReference type="Rhea" id="RHEA:55396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="ChEBI" id="CHEBI:138809"/>
            <dbReference type="EC" id="1.14.13.239"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine</text>
            <dbReference type="Rhea" id="RHEA:55368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="ChEBI" id="CHEBI:138809"/>
            <dbReference type="EC" id="1.14.13.239"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 2Fe-2S cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine metabolism; carnitine metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of an oxygenase subunit and a reductase subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PDR/VanB family. CntB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.239" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001287011.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403318.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FS8"/>
    <dbReference type="STRING" id="300267.SDY_1707"/>
    <dbReference type="EnsemblBacteria" id="ABB61827">
        <property type="protein sequence ID" value="ABB61827"/>
        <property type="gene ID" value="SDY_1707"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1707"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2061"/>
    <dbReference type="HOGENOM" id="CLU_003827_17_0_6"/>
    <dbReference type="OMA" id="CGTCETD"/>
    <dbReference type="UniPathway" id="UPA00117"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02098">
        <property type="entry name" value="Carnitine_monoox_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039003">
        <property type="entry name" value="Carnitine_monoox_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="233"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="321" mass="35730" checksum="22B489A500E08869" modified="2005-12-06" version="1">MSDYQMFEVQVSQVEPLTEQVKRFTLVATDGKPLPAFTGGSHIIVQMSDGDNQYSNAYSLLSSPHNTSSYQIAVRLEENSRGGSRFLHQQVKVGDRLTISTPNNLFALIPSARKHLFIAGGIGITPFLSHMAELQHSDVDWQLHYCSRNPESCAFRDELVQHPQAEKVHLHHSSTETRLELARLLADIEPGTHVYTCGPEALIEAVRSEAARLDIAADTLHFEQFAIEDKTGDAFTLVLARSGKEFVVPEEMTILQVIENNKAAKVECLCREGVCGTCETAILEGEADHRDQYFSDEERASQQSMLICCSRAKGKRLVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FW5</accession>
    <name>Q32FW5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403281.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FW5"/>
    <dbReference type="STRING" id="300267.SDY_1669"/>
    <dbReference type="EnsemblBacteria" id="ABB61790">
        <property type="protein sequence ID" value="ABB61790"/>
        <property type="gene ID" value="SDY_1669"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1669"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2015"/>
    <dbReference type="HOGENOM" id="CLU_033901_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="578" mass="61748" checksum="963C5E43840BA259" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G40</accession>
    <name>Q32G40_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydfG</name>
        <name evidence="2" type="ordered locus">SDY_1586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001296081.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403206.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G40"/>
    <dbReference type="SMR" id="Q32G40"/>
    <dbReference type="STRING" id="300267.SDY_1586"/>
    <dbReference type="EnsemblBacteria" id="ABB61715">
        <property type="protein sequence ID" value="ABB61715"/>
        <property type="gene ID" value="SDY_1586"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1586"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1905"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_6"/>
    <dbReference type="OMA" id="WRWMWET"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="248" mass="27247" checksum="148FB53C829A990C" modified="2005-12-06" version="1">MIVLVTGATAGFGECITRRFIQQGHKVIATGRRQERLQELKDELGDNLYIAQLDVRNRAAIEEMLASLPAEWSNIDILVNNAGLALGMEPAHKASIEDWETMIDTNNKGLVYMTRAVLPGMVERNHGHIINIGSTAGSWPYAGGNVYGATKAFVRQFSLNLRTDLHGTAVRVTDIEPGLVGGTEFSNVRFKGDDGKAEKTYQNTVALTPEDVSEAVWWVSTLPAHVNINTLEMMPVTQSYAGLNVHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G81</accession>
    <name>Q32G81_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G81"/>
    <dbReference type="EnsemblBacteria" id="ABB61674">
        <property type="protein sequence ID" value="ABB61674"/>
        <property type="gene ID" value="SDY_1538"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1538"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="93" mass="10095" checksum="56DE09CB2EBAC493" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITPYFKTVTTFCLCGGPGGKSETDGRADVDGFQHHDTPGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GA9</accession>
    <name>Q32GA9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative NAD(P)H nitroreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ydjA</name>
        <name evidence="5" type="ordered locus">SDY_1508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000339260.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403137.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GA9"/>
    <dbReference type="STRING" id="300267.SDY_1508"/>
    <dbReference type="EnsemblBacteria" id="ABB61646">
        <property type="protein sequence ID" value="ABB61646"/>
        <property type="gene ID" value="SDY_1508"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1508"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1802"/>
    <dbReference type="HOGENOM" id="CLU_070764_5_0_6"/>
    <dbReference type="OMA" id="IPEWEQV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02135">
        <property type="entry name" value="YdjA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026021">
        <property type="entry name" value="YdjA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000232">
        <property type="entry name" value="YdjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="183" mass="20076" checksum="AF07AD447C7C0225" modified="2005-12-06" version="1">MDALELLINRRSASRLADPAPTGEQLQNILRAGMRAPDHKSMQPWHFFVIEGEGRERFSAVLEQGAIAAGSDDKAIDKARNAPFRAQLIITVVAKCEENHKVPRWEQEMSAGCAVMAMQMAAVAQGFGGIWRSGALTESPVVREAFGCREQDKIVGFLYLGTPQLKASTSINVPDPTPFVTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GB3</accession>
    <name>Q32GB3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GB3"/>
    <dbReference type="EnsemblBacteria" id="ABB61642">
        <property type="protein sequence ID" value="ABB61642"/>
        <property type="gene ID" value="SDY_1504"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1504"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="76" mass="8318" checksum="9A0DC46B83476883" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITRVGGLYPGALANAFTPARFGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GN2</accession>
    <name>Q32GN2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-binding protein of peptide transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sapD</name>
        <name evidence="6" type="ordered locus">SDY_1378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001128862.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403014.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GN2"/>
    <dbReference type="STRING" id="300267.SDY_1378"/>
    <dbReference type="EnsemblBacteria" id="ABB61523">
        <property type="protein sequence ID" value="ABB61523"/>
        <property type="gene ID" value="SDY_1378"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1378"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1635"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_6"/>
    <dbReference type="OMA" id="PHGRVKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="330" mass="37703" checksum="063A446B524A4DF5" modified="2005-12-06" version="1">MPLLDIRNLTIEFKTGDEWVKAVDRVSMTLTEGEIRGLVGESGSGKSLIAKAICGVNKDNWRVTADRMRFDDIDLLRLSARERRKLVGHNVSMIFQEPQSCLDPSERVGRQLMQNIPAWTYKGRWWQRFVWRKRRAIELLHRVGIKDHKDAMRSFPYELTEGECQKVMIAIALANQPRLLIADEPTNSMEPTTQAQIFRLLTRLNQNSNTTILLISHDLQMLSQWADKINVLYCGQTVETAPSKELVTMPHHPYTQALIRAIPDFGSAMPHKSRLNTLPGAIPLLEQLPIGCRLGPRCPYAQRECIVTPRLTGAKNHLYACHFPLNMEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GQ9</accession>
    <name>Q32GQ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yciX</name>
        <name evidence="2" type="ordered locus">SDY_1349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402987.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GQ9"/>
    <dbReference type="EnsemblBacteria" id="ABB61496">
        <property type="protein sequence ID" value="ABB61496"/>
        <property type="gene ID" value="SDY_1349"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1349"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1598"/>
    <dbReference type="HOGENOM" id="CLU_203799_1_0_6"/>
    <dbReference type="OMA" id="WQLTTQQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="62" mass="7052" checksum="9023AC20D9BABE71" modified="2005-12-06" version="1">MESVGITMVGQEQLESSPLCQHSDNEPETKRECSVVIPDDWQLTSQQQAFIELFAEDDQPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H14</accession>
    <name>Q32H14_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative iron compound ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000173325.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402882.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H14"/>
    <dbReference type="STRING" id="300267.SDY_1240"/>
    <dbReference type="EnsemblBacteria" id="ABB61391">
        <property type="protein sequence ID" value="ABB61391"/>
        <property type="gene ID" value="SDY_1240"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1240"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1471"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_6"/>
    <dbReference type="OMA" id="HEFTWDF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="252" mass="27389" checksum="8095966B97FDC9A4" modified="2005-12-06" version="1">MTLLAVRHASLGYSRHPVLRDVSFTLSQGTICCLLGANGCGKTTLMRSILGVIPLLKGEVLLDSLPVQTLSHRQRAQAIAWVPQAHDGIFAFSVLDMVLMGLAPTISAFSVPGKQERLKATEQLEKLGILHLAARRWNTLSGGERQLALIARALVQQPRLLLLDEPASSLDFGHQIQLLDTLAQLKNNGMTMLMSTHHPLHANAITDSIILVEPDGRVTQGLPTEQLTTNKLAALYRVSAGQIHHHLSAISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H26</accession>
    <name>Q32H26_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H26"/>
    <dbReference type="STRING" id="300267.SDY_1228"/>
    <dbReference type="EnsemblBacteria" id="ABB61379">
        <property type="protein sequence ID" value="ABB61379"/>
        <property type="gene ID" value="SDY_1228"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1228"/>
    <dbReference type="HOGENOM" id="CLU_051473_0_0_6"/>
    <dbReference type="OMA" id="VNQHSEH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="377" mass="43418" checksum="677EC306C7C65F98" modified="2005-12-06" version="1">MGYGTGRFARKPAKKLHDVLEENRQNKQSEIPQEDLKERLKEIKEDILEENQSASQIEDRAEALRRMKECLITRQSMLDLSNLGLTSLPENLPPHLIEFNCSRNVLTALPEVMPKGLGVLECMENFLILLPKVQPPKLMVLKCYENYIIWLPELSTNLRVINCSENFLQFLPPSMPQYLYKLSCVGTNINSIPDEVLENLTRLKVFDCSSNDLISSPRLPPKLIIYYCGENQFKTVPVPQPRSLKVFSCNGNPWDKDNLPTLLKAVEGLKNQEGLEELLDFLHKEGLVDPEGLEKLEDLDDLMDLEFLDDPELLERVKVQEDLELLDQQLGLLSLERQQDSQPVNQQSEHEPESASRVKRDLSEVEFESTMKRKRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H57</accession>
    <name>Q32H57_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402839.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H57"/>
    <dbReference type="STRING" id="300267.SDY_1195"/>
    <dbReference type="EnsemblBacteria" id="ABB61348">
        <property type="protein sequence ID" value="ABB61348"/>
        <property type="gene ID" value="SDY_1195"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1195"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1414"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_1_6"/>
    <dbReference type="OMA" id="YWKKRPE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="106"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32339" checksum="2566DBBF5088D1BC" modified="2005-12-06" version="1">MVTLCHVFGVHRSSYRYWKNRPEKPDGRRAVLRSQVLELHGISHGSAGARSIATMATRRGYQMGRWLTGRLMKELGLVSCQQPTHRYKRGGHEHVAIPNYLERQFAVTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKPGGVMFHSDQGSHYTSRQFRQLLWRYQIRQSMSRRGNCRDNSPMERFFRSLKNEWMPVVGYVSFSEAAHAITDYIVGYYSALRPHEYNGGLPPNESENRYWKNSNSVASFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HA2</accession>
    <name>Q32HA2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yebI</name>
        <name evidence="8" type="ordered locus">SDY_1146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000571488.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402794.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HA2"/>
    <dbReference type="STRING" id="300267.SDY_1146"/>
    <dbReference type="EnsemblBacteria" id="ABB61303">
        <property type="protein sequence ID" value="ABB61303"/>
        <property type="gene ID" value="SDY_1146"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1146"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1349"/>
    <dbReference type="HOGENOM" id="CLU_028808_3_2_6"/>
    <dbReference type="OMA" id="RIDLMAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="261" mass="27807" checksum="4BA3579860F6A25F" modified="2005-12-06" version="1">MIELLFPGWLAGIMLACAAGPLGSFVVWRRMSYFGDTLAHTSLLGVAFGLLLDVNPFYAVIAVTLLLAGGLVWLEKRPQLAIDTLLGIMAHSALSLGLVVVSLMSNIRVDLMAYLFGDLLAVTPEDLISIAIGVVIVVAILFWQWRNLLSMTISPDLAFVDGVKLQRVKLLLMLVTALTIGVAMKFVGALIITSLLIIPAATARRFARTPEQMAGVAVLVGMVAVTGGLTFSAFYDTPAGPSVVLCAALLFIISMMKKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HR5</accession>
    <name>Q32HR5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response transcriptional regulator for torA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">torR</name>
        <name evidence="5" type="ordered locus">SDY_0969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001120104.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402631.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HR5"/>
    <dbReference type="STRING" id="300267.SDY_0969"/>
    <dbReference type="EnsemblBacteria" id="ABB61140">
        <property type="protein sequence ID" value="ABB61140"/>
        <property type="gene ID" value="SDY_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0969"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1120"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_6"/>
    <dbReference type="OMA" id="EMGSDDY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="132"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="132"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="230" mass="26277" checksum="5C975B498660E688" modified="2005-12-06" version="1">MPHHIVIVEDEPVTQARLQSYFTQEGYTISVTASGAGLREIMQNQPVDLILLDINLPDENGLMLTRALRERSTVGIILVTGRSDRIDRIVGLEMGADDYVTKLLELRELVVRVKNLLWRIDLARQVQPLTQDNCYRFAGYCLNVSRHTLERDGEPIKLTRAEYEMLVAFVTNPGEILSRERLLRMLSARRVENPDLRTVDVLIRRLRHKLSADLLVTQHGEGYFLAADVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I66</accession>
    <name>Q32I66_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF</name>
        <name evidence="5" type="ordered locus">SDY_0809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402480.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I66"/>
    <dbReference type="STRING" id="300267.SDY_0809"/>
    <dbReference type="EnsemblBacteria" id="ABB60991">
        <property type="protein sequence ID" value="ABB60991"/>
        <property type="gene ID" value="SDY_0809"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0809"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.933"/>
    <dbReference type="HOGENOM" id="CLU_000604_83_0_6"/>
    <dbReference type="OMA" id="YCDRIVI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="335"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="583" mass="63757" checksum="DD47A83E930880A5" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IB5</accession>
    <name>GSIA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="1">7.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gsiA</name>
        <name type="ordered locus">SDY_0758</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glutathione(out) + H2O = ADP + glutathione(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29791"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.4.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. Glutathione importer (TC 3.A.1.5.11) family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60942" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="7.4.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60942.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024259449.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402431.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IB5"/>
    <dbReference type="SMR" id="Q32IB5"/>
    <dbReference type="STRING" id="300267.SDY_0758"/>
    <dbReference type="EnsemblBacteria" id="ABB60942">
        <property type="protein sequence ID" value="ABB60942"/>
        <property type="gene ID" value="SDY_0758"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0758"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.872"/>
    <dbReference type="HOGENOM" id="CLU_000604_86_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000280028" description="Glutathione import ATP-binding protein GsiA">
        <location>
            <begin position="1"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="2">
        <location>
            <begin position="314"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P75796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="623" mass="69149" checksum="CE65AED9C9D1B4F8" modified="2007-03-06" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IE1</accession>
    <name>Q32IE1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IE1"/>
    <dbReference type="STRING" id="300267.SDY_0732"/>
    <dbReference type="EnsemblBacteria" id="ABB60916">
        <property type="protein sequence ID" value="ABB60916"/>
        <property type="gene ID" value="SDY_0732"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0732"/>
    <dbReference type="HOGENOM" id="CLU_183082_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="97" mass="11105" checksum="8B9D65920A15853A" modified="2005-12-06" version="1">MVADRFRNTFNAINNGEQYPVDELISIDSRCPLLEKLKLELTTPHRDFDRNGRVMVESKKDLAKREIPSPNVADAFIMAFAPIDTSLDIWEQLGRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32II4</accession>
    <name>Q32II4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tol-Pal system protein TolQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">tolQ</name>
        <name evidence="10" type="ordered locus">SDY_0685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ExbB/TolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000131320.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402362.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32II4"/>
    <dbReference type="STRING" id="300267.SDY_0685"/>
    <dbReference type="EnsemblBacteria" id="ABB60873">
        <property type="protein sequence ID" value="ABB60873"/>
        <property type="gene ID" value="SDY_0685"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0685"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.799"/>
    <dbReference type="HOGENOM" id="CLU_053325_2_2_6"/>
    <dbReference type="OMA" id="SWTYIFR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043213">
        <property type="term" value="P:bacteriocin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02202">
        <property type="entry name" value="TolQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014163">
        <property type="entry name" value="Tol-Pal_TolQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02796">
        <property type="entry name" value="tolQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="79"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="230" mass="25584" checksum="16321C74F22EEF17" modified="2005-12-06" version="1">MTDMNILDLFLKASLLVKLIMLILIGFSIASWAVIIQRTRILNAAAREAEAFEDKFWSGIELSRLYQESQGKRDNLTGSEQIFYSGFKEFVRLHRANSHAPEAVVEGASRAMRISMNRELENLETHIPFLGTVGSISPYIGLFGTVWGIMHAFIALGAVKQATLQMVAPGIAEALIATAIGLFAAIPAVMAYNRLNQRVNKLELNYDNFMEEFTAILHRQAFTVSESNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IJ6</accession>
    <name>Q32IJ6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylaspartate ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">SDY_0673</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12829"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:36986"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="4.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methylaspartate ammonia-lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.2" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000695033.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402350.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IJ6"/>
    <dbReference type="STRING" id="300267.SDY_0673"/>
    <dbReference type="EnsemblBacteria" id="ABB60861">
        <property type="protein sequence ID" value="ABB60861"/>
        <property type="gene ID" value="SDY_0673"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0673"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.786"/>
    <dbReference type="HOGENOM" id="CLU_055277_0_0_6"/>
    <dbReference type="OMA" id="RIEGPMD"/>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050096">
        <property type="term" value="F:methylaspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03314">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006395">
        <property type="entry name" value="Me_Asp_am_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022662">
        <property type="entry name" value="MeAsp_NH4-lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022665">
        <property type="entry name" value="MeAsp_NH4-lyase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07476">
        <property type="entry name" value="MAAL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05034">
        <property type="entry name" value="MAAL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017107">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00007">
        <property type="entry name" value="methylaspartate_ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01502">
        <property type="entry name" value="B_methylAsp_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAAL_N" evidence="14">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="MAAL_C" evidence="15">
        <location>
            <begin position="164"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>(2S,3S)-3-methyl-L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>(2S,3S)-3-methyl-L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB60861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="413" mass="45609" checksum="2C29453924F6A987" modified="2005-12-06" version="1">MKIKQALFTAGYSSFYFDDQQAIKNGAGHDGFFYTGEPVTQGFNAVRQAGECVSVQLILENGAVAVGDCTAVQYSEAGGRDPLFLAEHFIPFLNDHIKPLLVGRDVDAFLPNARFFDKLRIDGNLLHTAVRYGLSQALLDATALATGRLKTEVVCDEWQLPRVAESIPLFGQSGDDRYIAVDKMILKGIDVLPHALINNVEEKLGFKGEKLLEYVRWLSDRILSKRTSTRYHPTLHIDVYGTIGLIFDMDPLRCAQYIASLEKEAQGLPLYIEGPVDAGNKPDQIRLLTAITKELTRLGSGVKIVADEWCNTYQDIVDFTDAASCHMVQIKTPALGSIHNIVDAVLYCNSHSMEAYQGGTCNETDVSARTCVHVALAARPMRMLVKLGMGFDEGLDIVFNEMNRTIALLQAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IN9</accession>
    <name>Q32IN9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybfE</name>
        <name evidence="2" type="ordered locus">SDY_0625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402307.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IN9"/>
    <dbReference type="STRING" id="300267.SDY_0625"/>
    <dbReference type="EnsemblBacteria" id="ABB60818">
        <property type="protein sequence ID" value="ABB60818"/>
        <property type="gene ID" value="SDY_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0625"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.726"/>
    <dbReference type="HOGENOM" id="CLU_165368_1_0_6"/>
    <dbReference type="OMA" id="QLRVNKR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="120" mass="13873" checksum="2C466C6440D3F263" modified="2005-12-06" version="1">MYYGALSIRAEAWLIVSPEVTKIMAKEQTDRTTLDLFAHERRPGRPKTNPLSRDEQLRINKRNQLKRDKVRGLKRVELKLNAEAVEALNELAESRNMSRSELIEEMLMQQLAALRSQGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IW7</accession>
    <name>Q32IW7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402229.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IW7"/>
    <dbReference type="STRING" id="300267.SDY_0534"/>
    <dbReference type="EnsemblBacteria" id="ABB60740">
        <property type="protein sequence ID" value="ABB60740"/>
        <property type="gene ID" value="SDY_0534"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0534"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.630"/>
    <dbReference type="HOGENOM" id="CLU_120487_0_0_6"/>
    <dbReference type="OMA" id="MADIWTW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021845">
        <property type="entry name" value="DUF3440"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11922">
        <property type="entry name" value="DUF3440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="195" mass="23083" checksum="7EBDC577E3625688" modified="2005-12-06" version="1">MADIWTWYANHQSLCNPLYNLMYQAGVPLRHMRICEPFGPEQRQGLWLYHVIESDRWAAMCARVSGVKSGGIYAGHDNHFYGHRKILKPEHLDWQEYALLLLNSMPEKTAEHYRNKIAIYLHWYQKKGIEVPQTQQGDIGAKDIPSWRRICKVLLNNDYWCRALSFSPTKAKNYQRYNERIKGKRQEWGILCNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J46</accession>
    <name>Q32J46_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybaM</name>
        <name evidence="1" type="ordered locus">SDY_0453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000051143.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402150.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J46"/>
    <dbReference type="STRING" id="300267.SDY_0453"/>
    <dbReference type="EnsemblBacteria" id="ABB60661">
        <property type="protein sequence ID" value="ABB60661"/>
        <property type="gene ID" value="SDY_0453"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0453"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.536"/>
    <dbReference type="HOGENOM" id="CLU_202424_1_0_6"/>
    <dbReference type="OMA" id="ECNEIDP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019630">
        <property type="entry name" value="DUF2496_YbaM-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10689">
        <property type="entry name" value="DUF2496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="54" mass="6111" checksum="4E359C29DBF0FB9C" modified="2005-12-06" version="1">MSLENAPDDVKLAVDLIVLLEENQIPARTVLRALDIVKRDYEKKLQSDEASQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J57</accession>
    <name>Q32J57_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ybaL</name>
        <name evidence="11" type="ordered locus">SDY_0441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000546222.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402139.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J57"/>
    <dbReference type="STRING" id="300267.SDY_0441"/>
    <dbReference type="EnsemblBacteria" id="ABB60650">
        <property type="protein sequence ID" value="ABB60650"/>
        <property type="gene ID" value="SDY_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0441"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.523"/>
    <dbReference type="HOGENOM" id="CLU_005126_9_1_6"/>
    <dbReference type="OMA" id="TTFSHEG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004771">
        <property type="entry name" value="K/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00932">
        <property type="entry name" value="2a37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="10">
        <location>
            <begin position="419"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="558" mass="59419" checksum="4154708B3E9254D6" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JC1</accession>
    <name>Q32JC1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402075.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JC1"/>
    <dbReference type="EnsemblBacteria" id="ABB60586">
        <property type="protein sequence ID" value="ABB60586"/>
        <property type="gene ID" value="SDY_0372"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0372"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.441"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15250" checksum="E02B652A8FE7EE1B" modified="2005-12-06" version="1">MALICELDGQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JE9</accession>
    <name>Q32JE9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JE9"/>
    <dbReference type="EnsemblBacteria" id="ABB60558">
        <property type="protein sequence ID" value="ABB60558"/>
        <property type="gene ID" value="SDY_0343"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0343"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="138" mass="16088" checksum="C5CE76193A42784D" modified="2005-12-06" version="1">MPVAHADVALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMIISDDWGSYGREVPKHKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JN7</accession>
    <name>Q32JN7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ykfE</name>
        <name evidence="8" type="ordered locus">SDY_0246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ivy family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000533149.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401959.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JN7"/>
    <dbReference type="STRING" id="300267.SDY_0246"/>
    <dbReference type="EnsemblBacteria" id="ABB60470">
        <property type="protein sequence ID" value="ABB60470"/>
        <property type="gene ID" value="SDY_0246"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0246"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.276"/>
    <dbReference type="HOGENOM" id="CLU_109262_0_0_6"/>
    <dbReference type="OMA" id="LNACKPH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043086">
        <property type="term" value="P:negative regulation of catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036501">
        <property type="entry name" value="Inhibitor_vert_lysozyme_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014453">
        <property type="entry name" value="Inhibitor_vertebrate_lysozyme"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009103">
        <property type="entry name" value="Ivy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89872">
        <property type="entry name" value="SSF89872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221048" evidence="7">
        <location>
            <begin position="29"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="site" description="Important for lysozyme inhibition" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="85"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR009103-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="157" mass="16872" checksum="E624E2B46DAB6D81" modified="2005-12-06" version="1">MGRLSSGGMMFKAITTVAALVIATSAMAQDDLTISSLAKGETTKAAFNQMVQGHKLPAWVMKGGTYTPAQTVTLGDETYQVMSACKPHDCGSQRIAVMWSEKSNQMTGLFSTIDEKTSQEKLTWLNVNDALSIDGKTVLFAALTGSLENHPDGFNFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JT8</accession>
    <name>PYRH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uridylate kinase</fullName>
            <shortName evidence="1">UK</shortName>
            <ecNumber evidence="1">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Uridine monophosphate kinase</fullName>
            <shortName evidence="1">UMP kinase</shortName>
            <shortName evidence="1">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrH</name>
        <name type="ordered locus">SDY_0187</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP. Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UMP kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000224576.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401908.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JT8"/>
    <dbReference type="SMR" id="Q32JT8"/>
    <dbReference type="STRING" id="300267.SDY_0187"/>
    <dbReference type="PRIDE" id="Q32JT8"/>
    <dbReference type="EnsemblBacteria" id="ABB60419">
        <property type="protein sequence ID" value="ABB60419"/>
        <property type="gene ID" value="SDY_0187"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0187"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.217"/>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_6"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000054017" description="Uridylate kinase">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in allosteric activation by GTP" evidence="1">
        <location>
            <begin position="23"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="138"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <sequence length="241" mass="25970" checksum="F434CC32C636A715" modified="2005-12-06" version="1">MATNAKPVYKRILLKLSGEALQGTEGFGIDASILDRMAQEIKELVELGIQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDSYSWAEAISLLRNNRVVLLSAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVFTADPAKDPTATMYEQLTYSEVLEKELKVMDLAAFTLARDHKLPIRVFNMNKPGALRRVVMGEKEGTLITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JX6</accession>
    <name>Q32JX6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JX6"/>
    <dbReference type="STRING" id="300267.SDY_0147"/>
    <dbReference type="EnsemblBacteria" id="ABB60381">
        <property type="protein sequence ID" value="ABB60381"/>
        <property type="gene ID" value="SDY_0147"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0147"/>
    <dbReference type="HOGENOM" id="CLU_801412_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021728">
        <property type="entry name" value="DUF3300"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40269">
        <property type="entry name" value="PTHR40269"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="346" mass="39542" checksum="B41593F459D8999B" modified="2005-12-06" version="1">MSPPILMWSIFPTTTQPWFTGTGPILRIRRFICHHQPENRFLTALCADSAIAWALLPRTHYSAASTGMTTLMTIIMTMIIITTMAVIVTVMAGNTTATTSISTSAISTVSPVSILLIRIWHGGTIQTTVSVPYHDQDMAKRFHQTDVNGGMSATQLPAPTRDSQRQAAASQFQQRTLAAPVITRDTQRQAAAQRFNEAEHYGSYDDFRDFSRRQPLTQQQKDAARQRYQSASPEQRQAVHEKMQTNPQNQQRREAARERIQPASPEQRQVFKEKVQQRPLNQQQRDNARQRVQSASPEQRQVFREKVQESRPQRLNDSNHTARLNNEQRSAVRERLSERGARRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K07</accession>
    <name>Q32K07_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">murE</name>
        <name evidence="12" type="ordered locus">SDY_0115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000785151.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401839.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K07"/>
    <dbReference type="STRING" id="300267.SDY_0115"/>
    <dbReference type="EnsemblBacteria" id="ABB60350">
        <property type="protein sequence ID" value="ABB60350"/>
        <property type="gene ID" value="SDY_0115"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0115"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.134"/>
    <dbReference type="HOGENOM" id="CLU_022291_3_2_6"/>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="114"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="339"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="414"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="414"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="116"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB60350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="495" mass="53316" checksum="DF6725107B323060" modified="2005-12-06" version="1">MADRNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKGEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGETSAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEEHINPNCHGRWLKAIDVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALTTLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K15</accession>
    <name>Q32K15_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvI</name>
        <name evidence="12" type="ordered locus">SDY_0107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000425631.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401831.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K15"/>
    <dbReference type="STRING" id="300267.SDY_0107"/>
    <dbReference type="EnsemblBacteria" id="ABB60342">
        <property type="protein sequence ID" value="ABB60342"/>
        <property type="gene ID" value="SDY_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0107"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.126"/>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_6"/>
    <dbReference type="OMA" id="CFGTSGP"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="196"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="394"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB60342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="574" mass="63053" checksum="B27B6A1B7360CEB9" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KA6</accession>
    <name>YAAI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0412 protein YaaI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yaaI</name>
        <name type="ordered locus">SDY_0012</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0412 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60252" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60252.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000843568.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401740.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KA6"/>
    <dbReference type="EnsemblBacteria" id="ABB60252">
        <property type="protein sequence ID" value="ABB60252"/>
        <property type="gene ID" value="SDY_0012"/>
    </dbReference>
    <dbReference type="GeneID" id="66671696"/>
    <dbReference type="KEGG" id="sdy:SDY_0012"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.12"/>
    <dbReference type="HOGENOM" id="CLU_158661_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01372">
        <property type="entry name" value="UPF0412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020240">
        <property type="entry name" value="UPF0412_YaaI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10807">
        <property type="entry name" value="DUF2541"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000278590" description="UPF0412 protein YaaI">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="134" mass="14510" checksum="5D70443FE17A4C2F" modified="2007-02-20" version="2" precursor="true">MKSVFTISASLAISLMLCCTAQANDHKLLGVIAMPRNETNDLALKLPVCRIVKRIQLSADHGDLQLSGASVYFKAARSASQSLNIPSEIKEGQTTDWININSDNDNKRCVSKITFSGHTVNSSDMATLKIIGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q326W1</accession>
    <name>Q326W1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iso-IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_P134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Sd197</strain>
            <plasmid evidence="9">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406135.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326W1"/>
    <dbReference type="EnsemblBacteria" id="ABB64647">
        <property type="protein sequence ID" value="ABB64647"/>
        <property type="gene ID" value="SDY_P134"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P134"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5689"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_0_6"/>
    <dbReference type="OMA" id="MARVNIH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="10347" checksum="892D546B26572C63" modified="2005-12-06" version="1">MASVNIHCPRCQSAQVYRHGQNPKGHDRFRCRDCHRVFQLTYTYEARKPGIKELITEMAFNGAGVRDTARTLKIGINTVIRTLKNSRQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q326X7</accession>
    <name>Q326X7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406119.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326X7"/>
    <dbReference type="EnsemblBacteria" id="ABB64631">
        <property type="protein sequence ID" value="ABB64631"/>
        <property type="gene ID" value="SDY_P118"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P118"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5673"/>
    <dbReference type="HOGENOM" id="CLU_016763_3_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="137" mass="15156" checksum="3258EA08971824EA" modified="2005-12-06" version="1">MENRLSAVLAAREAEGRQMASLFEPAVPEVVSGEDVTQAEQPQQPVSPAINDKKSDAGVSVPAGGIEQELKMKPEEEMEQQLPPGISESGEVVDMTAYEAWQQENHPDIQQQMQRCEEVNINVHRERGEDVEPGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Y7</accession>
    <name>Q326Y7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbU</name>
        <name evidence="2" type="ordered locus">SDY_P108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406109.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Y7"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64621">
        <property type="protein sequence ID" value="ABB64621"/>
        <property type="gene ID" value="SDY_P108"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P108"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5663"/>
    <dbReference type="HOGENOM" id="CLU_009583_0_4_6"/>
    <dbReference type="OMA" id="WIKEGEN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="136"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="313" mass="35309" checksum="738C48D025798F23" modified="2005-12-06" version="1">MGIDITFALFRNSLHIPTAWRLLGIVHGFQPNAIVCHSGHDSNIVGLVRLFTWKHPFRIIRQKTYLTRKTKVFSINHFCDEVIVPGTSMKTHLEQEGCRTRVTVVPPGFDFQKLYVDSRNSLPPNVLSWLASRRGCPVIAQVGMLRPEKGHEFMLNLLFHLKMNGRQFCWLIVGSGTPELREHLQYQIDSMGMHDDVFIADNVFPAAPVYRVASLVVLPSENESFGMVLAEASAFSVPVLASQIGGIPDVIQNNQTGTLLPAGNKHAWMCALNDFFNDPGRFYQMARQAKQDIEERFDINKTALKILTLAKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Z0</accession>
    <name>Q326Z0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS3 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406106.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Z0"/>
    <dbReference type="EnsemblBacteria" id="ABB64618">
        <property type="protein sequence ID" value="ABB64618"/>
        <property type="gene ID" value="SDY_P105"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P105"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5659"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_12_6"/>
    <dbReference type="OMA" id="GYRMSER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038965">
        <property type="entry name" value="InsF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46889:SF1">
        <property type="entry name" value="PTHR46889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8127" checksum="91C714041650929B" modified="2005-12-06" version="1">MAASLRRQGLRAKASRKFSPVSYRAHGLPVSENLLEQDFYASGPNQKWAGDITYLRTDEVRLHPVSTEPHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q327A2</accession>
    <name>Q327A2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative IS orf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406094.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327A2"/>
    <dbReference type="EnsemblBacteria" id="ABB64606">
        <property type="protein sequence ID" value="ABB64606"/>
        <property type="gene ID" value="SDY_P093"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P093"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5643"/>
    <dbReference type="HOGENOM" id="CLU_023034_5_2_6"/>
    <dbReference type="OMA" id="AYLSHVI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039552">
        <property type="entry name" value="IS66_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13817">
        <property type="entry name" value="DDE_Tnp_IS66_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="1">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66_C" evidence="2">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="126" mass="14152" checksum="478979FADD2B6B6B" modified="2005-12-06" version="1">MNDLFAWLEEQEPCCPPDGPLNKAINYILNRRDELSCFLGDGAVPLDNNICERAIRPVVMGRKAWLFAGSLMAGNRAAQIMSLLETAKRNGLEPHAWLTDVLTRLPEWPEERLAELLPLEGFTFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q327J4</accession>
    <name>Q327J4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ</fullName>
            <ecNumber evidence="4">2.1.1.200</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA Cm32/Um32 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lasT</name>
        <name evidence="4" type="synonym">trmJ</name>
        <name evidence="6" type="ordered locus">SDY_4664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42936"/>
            <dbReference type="Rhea" id="RHEA-COMP:10107"/>
            <dbReference type="Rhea" id="RHEA-COMP:10290"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.200"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42932"/>
            <dbReference type="Rhea" id="RHEA-COMP:10288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10289"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.200"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.200" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001223171.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406002.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327J4"/>
    <dbReference type="STRING" id="300267.SDY_4664"/>
    <dbReference type="EnsemblBacteria" id="ABB64511">
        <property type="protein sequence ID" value="ABB64511"/>
        <property type="gene ID" value="SDY_4664"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4664"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5528"/>
    <dbReference type="HOGENOM" id="CLU_056931_3_1_6"/>
    <dbReference type="OMA" id="ELCQAVC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00050">
        <property type="entry name" value="rRNA_methyl_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="228" mass="25385" checksum="A61BEA21BA205BED" modified="2005-12-06" version="1">MRITIILVAPARAENIGAAARAMKTMGFSELRIVDSQAHLEPATRWVAHGSGDIIDNIKVFPTLVELLHDVDFTVATTARSRAKYHYYATPVELVPLLEEKSSWMSHAALVFGREDSGLTNEELALADVLTGVPMVADYPSLNLGQAVMVYCYQLATLIQQPTKSDTTADQHQLQALRERVMALLTTLAVADDIKLVDWLQQRLGLLEQRDTAMLHRLLHDIEKNITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q327J5</accession>
    <name>Q327J5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjjY</name>
        <name evidence="1" type="ordered locus">SDY_4663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001303782.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406001.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327J5"/>
    <dbReference type="EnsemblBacteria" id="ABB64510">
        <property type="protein sequence ID" value="ABB64510"/>
        <property type="gene ID" value="SDY_4663"/>
    </dbReference>
    <dbReference type="GeneID" id="67416079"/>
    <dbReference type="KEGG" id="sdy:SDY_4663"/>
    <dbReference type="HOGENOM" id="CLU_3184814_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="46" mass="4886" checksum="BA66EE9EB3952A21" modified="2005-12-06" version="1">MTKVRNCVLDALSINVNNIISLVVGTFPQDPTVSKTAVILTILTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q327P0</accession>
    <name>Q327P0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative carbon starvation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">yjiY</name>
        <name evidence="12" type="ordered locus">SDY_4607</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405956.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327P0"/>
    <dbReference type="STRING" id="300267.SDY_4607"/>
    <dbReference type="EnsemblBacteria" id="ABB64465">
        <property type="protein sequence ID" value="ABB64465"/>
        <property type="gene ID" value="SDY_4607"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4607"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5460"/>
    <dbReference type="HOGENOM" id="CLU_010531_2_0_6"/>
    <dbReference type="OMA" id="GTISGFH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="10">
        <location>
            <begin position="39"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="11">
        <location>
            <begin position="492"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB64465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="721" mass="77933" checksum="FD6E9EDA04289E79" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q327S4</accession>
    <name>Q327S4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dipeptide transport system permease protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dppC</name>
        <name evidence="9" type="ordered locus">SDY_4565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000084679.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405922.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327S4"/>
    <dbReference type="STRING" id="300267.SDY_4565"/>
    <dbReference type="EnsemblBacteria" id="ABB64431">
        <property type="protein sequence ID" value="ABB64431"/>
        <property type="gene ID" value="SDY_4565"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4565"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5403"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_6"/>
    <dbReference type="OMA" id="VPTYFRM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="300" mass="32323" checksum="3DF9FD0C575EA47A" modified="2005-12-06" version="1">MSQVTENKVISAPVPMTPLQEFWHYFKRNKGAVVGLVYVVIVLFIAIFANWIAPYNPAEQFRDALLAPPAWQEGGSMAHLLGTDDVGRDVLSRLMYGARLSLLVGCLVVVLSLIMGVILGLIAGYFGGQVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIGNAALALTFVALPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINIFPNCLAPLIVQASLGFSNAILDMAALGFLGMGAQPPTPEWGTMLSDVLQFAQSAWWVVTFPGLAILLTVLAFNLMGDGLRDALDPKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q327U3</accession>
    <name>Q327U3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405903.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327U3"/>
    <dbReference type="STRING" id="300267.SDY_4540"/>
    <dbReference type="EnsemblBacteria" id="ABB64412">
        <property type="protein sequence ID" value="ABB64412"/>
        <property type="gene ID" value="SDY_4540"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4540"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5367"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15321" checksum="0DFB34F6374685CA" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCLELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q328F4</accession>
    <name>Q328F4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Modulator of FtsH protease HflC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflC</name>
        <name evidence="5" type="ordered locus">SDY_4414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda. HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001232406.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405792.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328F4"/>
    <dbReference type="STRING" id="300267.SDY_4414"/>
    <dbReference type="MEROPS" id="I87.001"/>
    <dbReference type="EnsemblBacteria" id="ABB64301">
        <property type="protein sequence ID" value="ABB64301"/>
        <property type="gene ID" value="SDY_4414"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4414"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5212"/>
    <dbReference type="HOGENOM" id="CLU_059167_3_0_6"/>
    <dbReference type="OMA" id="DFFAFYR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005651">
        <property type="entry name" value="HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01932">
        <property type="entry name" value="hflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="334" mass="37597" checksum="3746B0C1D30911A1" modified="2005-12-06" version="1">MRKSVIAIIIIVLVVLYMSVFVVKEGERGITLRFGKVLRDDDNKPLVYEPGLHFKIPFIETVKMLDARIQTMDNQADRFVTKEKKDLIVDSYIKWCISDFSRYYLATGGGDISQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSAGTEDEVTTPAADNAIAEAAERVTAETKGKVPVINPNSMAALGIEVVDVRIKQINLPTEVSEAIYNRMRAEREAVARRHRSQGQEEAEKLRATADYEVTRTLAEAERQGRIMRGEGDAEAAKLFADAFSKDPDFYAFIRSLRAYENSFSGNQDVMVMSPDSDFFRYMKTPTSATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q328H4</accession>
    <name>Q328H4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Beta-lactamase</fullName>
            <ecNumber evidence="3 5">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ampC</name>
        <name evidence="8" type="ordered locus">SDY_4394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-C beta-lactamase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="3 5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378950.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405772.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328H4"/>
    <dbReference type="STRING" id="300267.SDY_4394"/>
    <dbReference type="MEROPS" id="S12.006"/>
    <dbReference type="EnsemblBacteria" id="ABB64281">
        <property type="protein sequence ID" value="ABB64281"/>
        <property type="gene ID" value="SDY_4394"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4394"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5190"/>
    <dbReference type="HOGENOM" id="CLU_020027_10_0_6"/>
    <dbReference type="OMA" id="ANRNYPN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001586">
        <property type="entry name" value="Beta-lactam_class-C_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00336">
        <property type="entry name" value="BETA_LACTAMASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220669" description="Beta-lactamase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="377" mass="41561" checksum="61433C024E9A3A4A" modified="2005-12-06" version="1">MFKTTLCALLITASCSTFAAPQKINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPATKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHISPGALDAETYGVKSTIEDMACWVRSNMNPRDINDKTLHQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDIIVNGSDNKIALAARSVKAITPPTPAVRASWVHKTGSTGGFGSYVAFIPEKELGIVMLANKNYPNPARVAAAWQILNALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q328H9</accession>
    <name>Q328H9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-lysine 2,3-aminomutase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">EF-P post-translational modification enzyme B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">yjeK</name>
        <name evidence="15" type="ordered locus">SDY_4389</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine = D-beta-lysine</text>
            <dbReference type="Rhea" id="RHEA:44148"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:84138"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the radical SAM superfamily. KamA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000940510.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405767.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328H9"/>
    <dbReference type="STRING" id="300267.SDY_4389"/>
    <dbReference type="EnsemblBacteria" id="ABB64276">
        <property type="protein sequence ID" value="ABB64276"/>
        <property type="gene ID" value="SDY_4389"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4389"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5184"/>
    <dbReference type="HOGENOM" id="CLU_032161_2_0_6"/>
    <dbReference type="OMA" id="PIWLNTH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022462">
        <property type="entry name" value="EpmB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00314">
        <property type="entry name" value="L-lysine_2_3-aminomutase_(yjeK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03821">
        <property type="entry name" value="EFP_modif_epmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="106"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR004911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB64276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="342" mass="38671" checksum="DF45BB3947094204" modified="2005-12-06" version="1">MAHIVTLNTPSREDWLTQLADVVTDPDELLRLLNIDADEKLLAGRSAKKLFALRVPRSFIDRMEKGNPDDPLLRQVLTSQDEFAIAPGFSTDPLEEQHSVVPGLLHKYHNRALLLVKGGCAVNCRYCFRRHFPYAENQGNKRNWQTALEYVAAHPELDEMIFSGGDPLMAKDHELDWLLTQLEAIPHIKRLRIHSRLPIVIPARITDALVERFSHSTLQILLVNHINHANEIDETFRQAMAKLRRAGVTLLNQSVLLRGVNDNAQTLANLSNALFDAGVMPYYLHVLDKVQGAAHFMVSDDEARQIMRELLTLVSGYLVPKLAREIGGEPSKTPLDLQLRQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q328I9</accession>
    <name>YTFE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Iron-sulfur cluster repair protein YtfE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ytfE</name>
        <name type="ordered locus">SDY_4379</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RIC family. YtfE subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000331456.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405757.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328I9"/>
    <dbReference type="SMR" id="Q328I9"/>
    <dbReference type="STRING" id="300267.SDY_4379"/>
    <dbReference type="EnsemblBacteria" id="ABB64266">
        <property type="protein sequence ID" value="ABB64266"/>
        <property type="gene ID" value="SDY_4379"/>
    </dbReference>
    <dbReference type="GeneID" id="66671871"/>
    <dbReference type="KEGG" id="sdy:SDY_4379"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5171"/>
    <dbReference type="HOGENOM" id="CLU_076075_2_0_6"/>
    <dbReference type="OMA" id="ACTTWRV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01606">
        <property type="entry name" value="RIC_YtfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023742">
        <property type="entry name" value="FeS-repair_YftE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019903">
        <property type="entry name" value="RIC_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36438">
        <property type="entry name" value="PTHR36438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04405">
        <property type="entry name" value="ScdA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03652">
        <property type="entry name" value="FeS_repair_RIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000291701" description="Iron-sulfur cluster repair protein YtfE">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01606"/>
        </source>
    </evidence>
    <sequence length="220" mass="24883" checksum="CC81A560EDA6A03B" modified="2005-12-06" version="1">MAYRDQPLGELALSIPRASALFRKYDMDYCCGGKQTLARAAARKELDVEVIEAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHDRHREQLPELILQATKVERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMGPISVMESEHDEAGELLEVIKHTTNNVTPPPEACTTWKAMYNGINELIDDLMDHISLENNVLFPRALAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q328R9</accession>
    <name>Q328R9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yjgQ</name>
        <name evidence="10" type="ordered locus">SDY_4286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LptF/LptG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405677.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328R9"/>
    <dbReference type="STRING" id="300267.SDY_4286"/>
    <dbReference type="EnsemblBacteria" id="ABB64186">
        <property type="protein sequence ID" value="ABB64186"/>
        <property type="gene ID" value="SDY_4286"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4286"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5053"/>
    <dbReference type="HOGENOM" id="CLU_028799_1_1_6"/>
    <dbReference type="OMA" id="WFTSKLA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030923">
        <property type="entry name" value="LptG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04408">
        <property type="entry name" value="LptG_lptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="361" mass="39722" checksum="8FB272312E49F167" modified="2005-12-06" version="1">MMQPFGVLDRYIGKTIFTTIMMTLFMLVSLSGIIKFVDQLKKAGQGSYDALGAGMYTLLSVPKDVQIFFPMAALLGALLGLGMLAQRSELVVMQASGFTRMQVALSVMKTAIPLVLLTMAIGEWAAPQGEQMARNYRAQAMYGGSLLSTQQGLWAKDGNNFVYIERVKGDEELGGISIYAFNENRRLQSVRYAATAKFDPEHKVWRLSQVDESDLTNPKQITGSQTVSGTWKTNLTPDKLGVVALDPDALSISGLHNYVKYLKSSGQDAGRYQLNMWSKIFQPLSVAVMMLMALSFIFGPLRSVPMGVRVVTGISFGFVFYVLDQIFGPLTLVYGIPPIIGALLPSASFFLISLWLLMRKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q328S8</accession>
    <name>OTC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="2">OTCase</shortName>
            <ecNumber evidence="2">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argI</name>
        <name type="ordered locus">SDY_4276</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000012924.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405668.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328S8"/>
    <dbReference type="SMR" id="Q328S8"/>
    <dbReference type="STRING" id="300267.SDY_4276"/>
    <dbReference type="EnsemblBacteria" id="ABB64177">
        <property type="protein sequence ID" value="ABB64177"/>
        <property type="gene ID" value="SDY_4276"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4276"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5038"/>
    <dbReference type="HOGENOM" id="CLU_043846_3_1_6"/>
    <dbReference type="OMA" id="KYNGYEQ"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000065118" description="Ornithine carbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <sequence length="334" mass="36832" checksum="9661A7F20FC600ED" modified="2005-12-06" version="1">MSGFYHKHFLKLLDFTPAELNSLLQLAAKLKADKKSGKEEAKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLVYAGDARNNMGNSMLEAAALTGLGLRLVAPQACWPEAALVTECRALAQQNGGNITLTEDVAQGVEGADFIYTDVWVSMGEAKEKWAERIALLRDYQVNNKMMQLTGNPEVKFLHCLPAFHDDQTTLGKKMAEEFGLHGGMEVTDEVFESAASIVFDQAENRMHTIKAVMVATLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q329U5</accession>
    <name>Q329U5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISSfl2 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016857.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405401.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329U5"/>
    <dbReference type="STRING" id="300267.SDY_3983"/>
    <dbReference type="EnsemblBacteria" id="ABB63910">
        <property type="protein sequence ID" value="ABB63910"/>
        <property type="gene ID" value="SDY_3983"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3983"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4696"/>
    <dbReference type="HOGENOM" id="CLU_036902_2_3_6"/>
    <dbReference type="OMA" id="KQSIHHI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="14"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="398" mass="43120" checksum="714E4D8DF8DFCA86" modified="2005-12-06" version="1">MTESSDYESVQVFIGVDVGKDTHHAVAINRSGKRLFDKALPNDENKLRSLISDLKQHGQILLVVDQPATIGALPVAVARSEGVLVGYLPGLAMRRIADLHAGEAKTDARDAAIIAEAARTLPHALRTLKLADEQIAELSMLCGFNDDLAAQTTQASNRIRGLLTQIHPALERVLGPRLEHPAVLDLLQRYPSPEKLASLGEKKLAAQLCKLAPRLGKRLAADIAQALAEQTVVVPGTNAAAVVLPRLALQLITLRKQRDEVALEVEQRVLAHPLYPVLTSMPGVGVRTAARLPTEVACRAFASAAHLAAYAGLAPVTRRSGSSIRGEHPSRRGNKALKRALFLSAFAALRDPLSRAYYTRKMSQGKRHNQALIALARRRCDVLFAMMRDGTFYTPQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q329U8</accession>
    <name>Q329U8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetolactate synthase II, valine insensitive, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ilvM</name>
        <name evidence="2" type="ordered locus">SDY_3979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000983255.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405398.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329U8"/>
    <dbReference type="SMR" id="Q329U8"/>
    <dbReference type="STRING" id="300267.SDY_3979"/>
    <dbReference type="EnsemblBacteria" id="ABB63907">
        <property type="protein sequence ID" value="ABB63907"/>
        <property type="gene ID" value="SDY_3979"/>
    </dbReference>
    <dbReference type="GeneID" id="67414443"/>
    <dbReference type="KEGG" id="sdy:SDY_3979"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4692"/>
    <dbReference type="HOGENOM" id="CLU_183627_0_0_6"/>
    <dbReference type="OMA" id="RGFQICS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="9703" checksum="CEB6B5211262E0AF" modified="2005-12-06" version="1">MMQHQVNVSARFNPETLERVLRVVRHRGFHVCSMNMAAASDAQNINIELTVASPRSVDLLFSQLNKLVDVAHVAICQSTTTSQQIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q329V1</accession>
    <name>Q329V1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-threonine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ilvA</name>
        <name evidence="13" type="ordered locus">SDY_3976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="11"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000785597.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405395.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329V1"/>
    <dbReference type="STRING" id="300267.SDY_3976"/>
    <dbReference type="EnsemblBacteria" id="ABB63904">
        <property type="protein sequence ID" value="ABB63904"/>
        <property type="gene ID" value="SDY_3976"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3976"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4689"/>
    <dbReference type="HOGENOM" id="CLU_021152_6_0_6"/>
    <dbReference type="OMA" id="VNFPQRA"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="12">
        <location>
            <begin position="339"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="12">
        <location>
            <begin position="434"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="514" mass="56216" checksum="37537491E716320B" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q329X0</accession>
    <name>Q329X0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipid III flippase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">wzxE</name>
        <name evidence="6" type="ordered locus">SDY_3956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Probably part of a complex composed of WzxE, WzyE and WzzE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000050253.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405376.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329X0"/>
    <dbReference type="STRING" id="300267.SDY_3956"/>
    <dbReference type="EnsemblBacteria" id="ABB63885">
        <property type="protein sequence ID" value="ABB63885"/>
        <property type="gene ID" value="SDY_3956"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3956"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4667"/>
    <dbReference type="HOGENOM" id="CLU_042154_0_0_6"/>
    <dbReference type="OMA" id="KFTIMAL"/>
    <dbReference type="UniPathway" id="UPA00566"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009246">
        <property type="term" value="P:enterobacterial common antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13125">
        <property type="entry name" value="MATE_like_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02024">
        <property type="entry name" value="WzxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044550">
        <property type="entry name" value="WzxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032896">
        <property type="entry name" value="WzxE_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="416" mass="45087" checksum="320F06FF649BF7B5" modified="2005-12-06" version="1">MSLAKASLWTAASTLVKIGAGLLVGKLLAVSFGPAGLGLAANFRQLITVLGVLAGAGIFNGVTKYVAQYHDNPQQLRRVVGTSSAMVLGFSTLMALVFVLAAAPISQGLFGNTDYQGLVRLVALVQMGIAWGNLLLALMKGFRDAAGNALSLIVGSLIGVLAYYVSYRLGGYEGALLGLALIPALVVIPAAIMLIKRDVIPLSYLKPRWDNGLAGQLSKFTLMALITSVTLPVAYIMMRKLLAAQYSWDEVGIWQGVSSISDAYLQFITASFSVYLLPTLSRLTEKRDITREVVKSLKFVLPAVAAASFTVWLLRDFAIWLLLSNKFTAMRDLFAWQLVGDVLKVGAYVFGYLVIAKASLRFYILAEVSQFTLLMVFAHWLIPAHGALGAAQAYMATYIVYFSLCCGVFLLWRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Z0</accession>
    <name>Q329Z0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000751607.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405356.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Z0"/>
    <dbReference type="STRING" id="300267.SDY_3931"/>
    <dbReference type="EnsemblBacteria" id="ABB63865">
        <property type="protein sequence ID" value="ABB63865"/>
        <property type="gene ID" value="SDY_3931"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3931"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4642"/>
    <dbReference type="HOGENOM" id="CLU_059734_0_0_6"/>
    <dbReference type="OMA" id="EIPYQKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220963" evidence="2">
        <location>
            <begin position="22"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="300" mass="32748" checksum="B605A4558A7610D9" modified="2005-12-06" version="1">MKKTLATLFLLTCLGSPSAYADNALILQTDFSLKDGAVSAMKGVAFGVDHNLKIFDLTHEIPPYNIWEGAYRLYQTASYWPQGSVFVSVVDPGVGTDRKSVVLKTKNGQYFVSPDNGTLTLVAESLGIESVRQIDEKNNRLKGSEKSYTFHGRDVYAYTGARLASGAISFEQVGPELPAKVVELSYQKAKATKGEVKGNIPILDIQYGNVWSNISDELLNQAGIKLNDTLCVTISEGSQQKYEGKMPYVASFGDVPEGQPMVYLNSLLNVSVALNMDNFAQKHQVASGANWNIDVKKCAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A70</accession>
    <name>RHAS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional activator RhaS</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-rhamnose operon regulatory protein RhaS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhaS</name>
        <name type="ordered locus">SDY_3841</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Activates expression of the rhaBAD and rhaT operons.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds DNA as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000217372.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405276.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A70"/>
    <dbReference type="SMR" id="Q32A70"/>
    <dbReference type="STRING" id="300267.SDY_3841"/>
    <dbReference type="EnsemblBacteria" id="ABB63785">
        <property type="protein sequence ID" value="ABB63785"/>
        <property type="gene ID" value="SDY_3841"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3841"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4536"/>
    <dbReference type="HOGENOM" id="CLU_000445_88_5_6"/>
    <dbReference type="OMA" id="GHYPSHW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019299">
        <property type="term" value="P:rhamnose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01534">
        <property type="entry name" value="HTH_type_RhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023609">
        <property type="entry name" value="Tscrpt_reg_HTH_RhaS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0684">Rhamnose metabolism</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000068708" description="HTH-type transcriptional activator RhaS">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="174"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with sigma-70" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with sigma-70" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01534"/>
        </source>
    </evidence>
    <sequence length="278" mass="32331" checksum="3476DD8DA8EB8C50" modified="2005-12-06" version="1">MTVLPSVDFFPSGNTSVAIEPRLPQADFPEHHHDFHEIVIVEHGTGIHVFNGQPYTITGGTVCFVRDHDRYLYEHTDNLCLTNVLYRSPDRFQFLAGLNQLLPQELDGQYPSHWRVNHSVLQQVRQLVAQMEQQEGENDLPSTASREILFMQLLLLLRKSSLQENLENSASRLNLLLAWLEDHFADEVNWDAVADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLMKARHLLRHSEASVTDIAYRCGFSDSNHFSTLFRREFNWSPRDIRQGRDGFLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A94</accession>
    <name>ZAPB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein ZapB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">zapB</name>
        <name type="ordered locus">SDY_3816</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Localizes to the septum at mid-cell, in a FtsZ-like pattern.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001296623.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405252.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A94"/>
    <dbReference type="SMR" id="Q32A94"/>
    <dbReference type="STRING" id="300267.SDY_3816"/>
    <dbReference type="EnsemblBacteria" id="ABB63761">
        <property type="protein sequence ID" value="ABB63761"/>
        <property type="gene ID" value="SDY_3816"/>
    </dbReference>
    <dbReference type="GeneID" id="67417561"/>
    <dbReference type="KEGG" id="sdy:SDY_3816"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4507"/>
    <dbReference type="HOGENOM" id="CLU_171174_2_0_6"/>
    <dbReference type="OMA" id="VQSAQHG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01196">
        <property type="entry name" value="ZapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009252">
        <property type="entry name" value="Cell_div_ZapB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06005">
        <property type="entry name" value="ZapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000333934" description="Cell division protein ZapB">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="81" mass="9635" checksum="B01DC1A433A1D01B" modified="2005-12-06" version="1">MTMSLEVFEKLEAKVQQAIDTITLLQMEIEELKEKNNSLSQEVQNAQHQREELERENNHLKEQQNGWQERLQALLGRMEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AB2</accession>
    <name>Q32AB2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AB2"/>
    <dbReference type="EnsemblBacteria" id="ABB63743">
        <property type="protein sequence ID" value="ABB63743"/>
        <property type="gene ID" value="SDY_3798"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3798"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="7883" checksum="60321A97742EC426" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITKKARFGKIKLSAIIKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AC5</accession>
    <name>Q32AC5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS system fructose-like IIB component 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">frwB</name>
        <name evidence="5" type="ordered locus">SDY_3785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000161265.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405221.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AC5"/>
    <dbReference type="SMR" id="Q32AC5"/>
    <dbReference type="STRING" id="300267.SDY_3785"/>
    <dbReference type="EnsemblBacteria" id="ABB63730">
        <property type="protein sequence ID" value="ABB63730"/>
        <property type="gene ID" value="SDY_3785"/>
    </dbReference>
    <dbReference type="GeneID" id="67417533"/>
    <dbReference type="KEGG" id="sdy:SDY_3785"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4474"/>
    <dbReference type="HOGENOM" id="CLU_013155_2_1_6"/>
    <dbReference type="OMA" id="TPHDIAQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="106" mass="11248" checksum="F712189F18489D3D" modified="2005-12-06" version="1">MTKIIAVTACPSGVAHTYMAAEALESAAKAKGWEVKVETQGSIGLENELTAEDVASADMVILTKDIGIKFEERFAGKTIVRVNISDAVKRADAIMSKIEAHLAQTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AG0</accession>
    <name>RPOC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="1">RNAP subunit beta'</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoC</name>
        <name type="ordered locus">SDY_3740</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000653954.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405186.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AG0"/>
    <dbReference type="SMR" id="Q32AG0"/>
    <dbReference type="STRING" id="300267.SDY_3740"/>
    <dbReference type="PRIDE" id="Q32AG0"/>
    <dbReference type="EnsemblBacteria" id="ABB63695">
        <property type="protein sequence ID" value="ABB63695"/>
        <property type="gene ID" value="SDY_3740"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3740"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4435"/>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_6"/>
    <dbReference type="OMA" id="YRNIRVE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000225578" description="DNA-directed RNA polymerase subunit beta'">
        <location>
            <begin position="1"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="814"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="888"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="895"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="898"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <sequence length="1407" mass="155188" checksum="AE1638F86C178B38" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AJ1</accession>
    <name>Q32AJ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhfV</name>
        <name evidence="3" type="ordered locus">SDY_3702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000006973.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405155.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AJ1"/>
    <dbReference type="STRING" id="300267.SDY_3702"/>
    <dbReference type="EnsemblBacteria" id="ABB63664">
        <property type="protein sequence ID" value="ABB63664"/>
        <property type="gene ID" value="SDY_3702"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3702"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4392"/>
    <dbReference type="HOGENOM" id="CLU_054760_1_1_6"/>
    <dbReference type="OMA" id="MVKCGFI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00530">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="292" mass="32963" checksum="2DC17B3B17ED6265" modified="2005-12-06" version="1">MSFDPTGYTFAHEHLHIDLSGFKNNVDCRLDQYAFICQEMNDLMTRGVRNVIEMTNRYMGRNAQFMLDVMRETGINVVACTGYYQDVFFPEHVATRSVQELAQEMVDEIEQGIDGTELKAGIIAEIGSSEGKITPLEEKVFIAAALAHNQTGRPISTHTSFSTMGLEQLALLQAHGVDLSRVTVGHCDLKDNLDNILKMIDLGAYVQFDTIGKNSYYPDEKRIAMLHALRDRGLLNRVMLSMDITRRSHLKANGGYGYDYLLTTFIPQLRQSGFSQADVDVMLRENPSQFFQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AK2</accession>
    <name>AROK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shikimate kinase 1</fullName>
            <shortName evidence="1">SK 1</shortName>
            <ecNumber evidence="1">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroK</name>
        <name type="ordered locus">SDY_3689</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000818618.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405144.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AK2"/>
    <dbReference type="SMR" id="Q32AK2"/>
    <dbReference type="STRING" id="300267.SDY_3689"/>
    <dbReference type="EnsemblBacteria" id="ABB63653">
        <property type="protein sequence ID" value="ABB63653"/>
        <property type="gene ID" value="SDY_3689"/>
    </dbReference>
    <dbReference type="GeneID" id="67417016"/>
    <dbReference type="KEGG" id="sdy:SDY_3689"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4377"/>
    <dbReference type="HOGENOM" id="CLU_057607_2_2_6"/>
    <dbReference type="OMA" id="IGKHLFE"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000237931" description="Shikimate kinase 1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <sequence length="173" mass="19538" checksum="5681B562B5CD4674" modified="2005-12-06" version="1">MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADVGWVFDLEGEEGFRDREEKVINELTEKQGIVLATGGGSVKSRETRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLHVETPPREVLEALANERNPLYEEIADVTIRTDDQSAKVVANQIIHMLESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AL0</accession>
    <name>Q32AL0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yrfF</name>
        <name evidence="10" type="ordered locus">SDY_3680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IgaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000104529.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405136.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AL0"/>
    <dbReference type="STRING" id="300267.SDY_3680"/>
    <dbReference type="EnsemblBacteria" id="ABB63645">
        <property type="protein sequence ID" value="ABB63645"/>
        <property type="gene ID" value="SDY_3680"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3680"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4367"/>
    <dbReference type="HOGENOM" id="CLU_014723_0_0_6"/>
    <dbReference type="OMA" id="DLIYPPH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010771">
        <property type="entry name" value="IgaA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07095">
        <property type="entry name" value="IgaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="711" mass="79271" checksum="8242CC0C921D22CC" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AQ4</accession>
    <name>Q32AQ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport of nickel membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nikB</name>
        <name evidence="9" type="ordered locus">SDY_3632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000947084.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405092.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AQ4"/>
    <dbReference type="STRING" id="300267.SDY_3632"/>
    <dbReference type="EnsemblBacteria" id="ABB63601">
        <property type="protein sequence ID" value="ABB63601"/>
        <property type="gene ID" value="SDY_3632"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3632"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4311"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_2_6"/>
    <dbReference type="OMA" id="PNGYAAD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014156">
        <property type="entry name" value="Nickel_NikB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02789">
        <property type="entry name" value="nickel_nikB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="98"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="314" mass="35290" checksum="92AB2989C5782CA3" modified="2005-12-06" version="1">MLRYVLRRFLLLIPMVLAASVIIFLMLRLGTGDPALDYLRLSNLPPTPEMLASTRTMLGLDQPLYVQYGTWLWKALHLDFGISFATQRPVLDDMLNFLPATLELAGAALVLILLTSVPLGIWAARHRDRLPDFAVRFIAFLGVSMPNFWLAFLLVMAFSVYLQWLPAMGYGGWRHIILPAVSIAFMSLAINARLLRASMLDVAGQRHVTWARLRGLNDKQTERRHILRNASLPMITAVGMHIGELIGGTMIIENIFAWPGVGRYAVSAIFNRDYPVIQCFTLMMVVVFVVCNLIVDLLNAALDPRIRRHEGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AR2</accession>
    <name>Q32AR2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inner membrane lipoprotein DcrB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dcrB</name>
        <name evidence="2" type="ordered locus">SDY_3623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis. Essential for lipoprotein maturation under conditions where membrane fluidity may be altered.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DcrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AR2"/>
    <dbReference type="STRING" id="300267.SDY_3623"/>
    <dbReference type="EnsemblBacteria" id="ABB63593">
        <property type="protein sequence ID" value="ABB63593"/>
        <property type="gene ID" value="SDY_3623"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3623"/>
    <dbReference type="HOGENOM" id="CLU_125378_0_0_6"/>
    <dbReference type="OMA" id="ACDNSDT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02248">
        <property type="entry name" value="DcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046406">
        <property type="entry name" value="DcrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014894">
        <property type="entry name" value="DcrB/EagT6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08786">
        <property type="entry name" value="DcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="203" mass="22131" checksum="43AF66B141137D06" modified="2005-12-06" version="1">MIRWMNEPLWPFIERKKSMRNLVKYVGIGLLVMGLAACDDKDTNATAQGSVAESNATGNPVNLLDGKLSFSLPADMTDQSGKLGTQANNMHVWSDATGQKAVIVIMGDDPKEDLAVLAKRLEDQQRSRDPQLQVVTNKAIELKGHKMQQLDSIISAKGQTAYSSVILGNVGNQLLTMQITLPADDQQKAQTTAENIINTLVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AU0</accession>
    <name>Q32AU0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhhX</name>
        <name evidence="3" type="ordered locus">SDY_3591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000236316.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405056.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AU0"/>
    <dbReference type="STRING" id="300267.SDY_3591"/>
    <dbReference type="EnsemblBacteria" id="ABB63565">
        <property type="protein sequence ID" value="ABB63565"/>
        <property type="gene ID" value="SDY_3591"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3591"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4264"/>
    <dbReference type="HOGENOM" id="CLU_023194_19_0_6"/>
    <dbReference type="OMA" id="VAHIYRR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="135"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="345" mass="38741" checksum="E45A64FE28FE1D6A" modified="2005-12-06" version="1">MVINCAFIGFGKSTTRYHLPYVLNRKDSWHVAHIFRRHAKPEEQAPIYSHIHFTSDLNEVLNDPDVKLVVVCTHADSHFEYAKRALEAGKNVLVEKPFTPTLAQAKELFALAKSKGLTVTPYQNRRFDSCFLTAKKAIESGKLGEIVEVESHFDYYRPVAETKPGLPQDGAFYGLGVHTMDQIISLFGRPDHVAYDIRSLRNKANPDDTFEAQLFYGDLKAIVKTSHLVKIDYPKFIVHGKKGSFIKYGIDQQETSLKANIMPGEPGFAADDSVGVLEYVNDEGVTVREEMKPEMGDYGRVYDALYQTITNGAPNYVKESEVLTNLEILERGFEQASPSTVTLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AX3</accession>
    <name>Q32AX3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1021</name>
        <name evidence="4" type="ordered locus">SDY_3558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402677.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405023.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61186">
        <property type="protein sequence ID" value="ABB61186"/>
        <property type="gene ID" value="SDY_1021"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63532">
        <property type="protein sequence ID" value="ABB63532"/>
        <property type="gene ID" value="SDY_3558"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1021"/>
    <dbReference type="KEGG" id="sdy:SDY_3558"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1192"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15296" checksum="7D7E354A8DE09977" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVESHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AY2</accession>
    <name>Q32AY2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative permease of iron compound ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">shuU</name>
        <name evidence="8" type="ordered locus">SDY_3548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019013.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405014.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AY2"/>
    <dbReference type="STRING" id="300267.SDY_3548"/>
    <dbReference type="TCDB" id="3.A.1.14.18">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63523">
        <property type="protein sequence ID" value="ABB63523"/>
        <property type="gene ID" value="SDY_3548"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3548"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4210"/>
    <dbReference type="HOGENOM" id="CLU_013016_0_3_6"/>
    <dbReference type="OMA" id="MQGVFGN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="318" mass="33954" checksum="6E01795CC662F3C6" modified="2005-12-06" version="1">MGLSLLLLALVLFGASQGALKISFDALFGEEYRDIWLNIRLPRVLLAVLVGAALATAGVIMQGLFRNPMADPGLLGVSSGSALMVGVAIVLPFSFPVVLVLYEQMVFAIAGSLVVCTIIFLITQRHRDGSMMQLLLAGIAINALCGAAIGILSYIGDEQQLRQLTLWMMGNLGQAQWPTLLVASSFILPAIIATTCLAGTLNLLQLGDEEAHYLGVNVKRKRQQLLLVSSLLVGAAVSVSGIIGFIGLVIPHLIRMTTGANHRWLIPCSALAGACLLLMADTLARTLVQPAEMPVGLLTSLLGGPYFMWLILRNRRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B05</accession>
    <name>Q32B05_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fic</name>
        <name evidence="2" type="ordered locus">SDY_3523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001280683.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404991.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B05"/>
    <dbReference type="STRING" id="300267.SDY_3523"/>
    <dbReference type="EnsemblBacteria" id="ABB63500">
        <property type="protein sequence ID" value="ABB63500"/>
        <property type="gene ID" value="SDY_3523"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3523"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4178"/>
    <dbReference type="HOGENOM" id="CLU_080158_0_2_6"/>
    <dbReference type="OMA" id="FCHFEYI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="54"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="200" mass="23006" checksum="E5D513FAF843F4EA" modified="2005-12-06" version="1">MSDKFGEGRDPYLYSGLDIMRNRLNIRQQQRLEQAAYEMTVLRAATIELGPLVRGLPHLRTIHRQLYQDIFDWAGQLREVDIYQGDTPFCHFAYIEKEGNALMQDLEEEGYLVGLEKAKFVERLAHYYCEINVLHPFRVGSGLAQRIFFEQLAIHAGYQLSWQGIEKEAWNQVNQSGAMGDLTALQMIFSKVVSEAGESE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-24" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B38</accession>
    <name>RL16_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplP</name>
        <name type="ordered locus">SDY_3489</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000941212.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404958.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B38"/>
    <dbReference type="SMR" id="Q32B38"/>
    <dbReference type="STRING" id="300267.SDY_3489"/>
    <dbReference type="EnsemblBacteria" id="ABB63467">
        <property type="protein sequence ID" value="ABB63467"/>
        <property type="gene ID" value="SDY_3489"/>
    </dbReference>
    <dbReference type="GeneID" id="67415354"/>
    <dbReference type="KEGG" id="sdy:SDY_3489"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4142"/>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_6"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000062197" description="50S ribosomal protein L16">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <sequence length="136" mass="15281" checksum="445A9B167F7564D1" modified="2005-12-06" version="1">MLQPKRTKFRKMHKGRNRGLAQGTDVSFGSFGLKAVGRGRLTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLAVRMGKGKGNVEYWVALIQPGKVLYEMDGVPEELAREAFKLAAAKLPIKTTFVTKTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B87</accession>
    <name>Q32B87_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhdH</name>
        <name evidence="3" type="ordered locus">SDY_3428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001148475.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404909.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B87"/>
    <dbReference type="STRING" id="300267.SDY_3428"/>
    <dbReference type="EnsemblBacteria" id="ABB63418">
        <property type="protein sequence ID" value="ABB63418"/>
        <property type="gene ID" value="SDY_3428"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3428"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4086"/>
    <dbReference type="HOGENOM" id="CLU_026673_26_3_6"/>
    <dbReference type="OMA" id="AQMDYNS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014188">
        <property type="entry name" value="Acrylyl-CoA_reductase_AcuI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF1">
        <property type="entry name" value="PTHR43677:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02823">
        <property type="entry name" value="oxido_YhdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="12"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="324" mass="34662" checksum="2E1B4C1ED0BDE0D3" modified="2005-12-06" version="1">MQALLLEQQDGKTLASVQTLDESRLPEGDVTVDVHWSSLNYKDALAITGKGKIIRNFPMIPGIDFAGTVRTSEDPRFHAGQEVLLTGWGVGENHWGGLAEQARVKGDWLVAMPQGLDARKAMIIGTAGFTAMLCVMALEDAGVRPQDGEIVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTHEYLKSLGASRILPRDEFAESRPLEKQVWAGAIDTVGDKVLAKVLAQMNYGGCVAACGLAGGFTLPTTVMPFILRNVRLQGVDSVMTPPERRAQAWQRLVADLPESFSTQAAKEISLSEAPNFAEAIINNQIQGRTLVKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BB5</accession>
    <name>Q32BB5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sialic acid transporter NanT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sialic acid permease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sialic acid/H(+) symporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nanT</name>
        <name evidence="8" type="ordered locus">SDY_3399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the proton-dependent transport of sialic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-acetylneuraminate(out)</text>
            <dbReference type="Rhea" id="RHEA:28987"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35418"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BB5"/>
    <dbReference type="STRING" id="300267.SDY_3399"/>
    <dbReference type="EnsemblBacteria" id="ABB63390">
        <property type="protein sequence ID" value="ABB63390"/>
        <property type="gene ID" value="SDY_3399"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3399"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_8_6"/>
    <dbReference type="OMA" id="HWLLLTY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015538">
        <property type="term" value="F:sialic acid:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01238">
        <property type="entry name" value="MFS_NanT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004742">
        <property type="entry name" value="SA_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00891">
        <property type="entry name" value="2A0112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="31"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="506" mass="54661" checksum="DD2479FEFE7EBE16" modified="2005-12-06" version="1">MGIAHRGRLTMSTTTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQGEFGLTTVQAASLISAAFISRWFGGLMLGAMGDRYGRRLAMVTSIVLFSAGTLACGFAPGYITMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIANIVMTLAAATALWFCFAGNLQNAAIVAVLGLLCAAIFISFMVQSTGKRWPTGVMLMVVVLFAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQLLIIPVFAIGGANVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQRAAGLGFTYNVGALGGALAPIIGALVAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDGKPFSGAVPFGSAKNDLVKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BJ2</accession>
    <name>Q32BJ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yhaD</name>
        <name evidence="5" type="ordered locus">SDY_3318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BJ2"/>
    <dbReference type="STRING" id="300267.SDY_3318"/>
    <dbReference type="EnsemblBacteria" id="ABB63313">
        <property type="protein sequence ID" value="ABB63313"/>
        <property type="gene ID" value="SDY_3318"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3318"/>
    <dbReference type="HOGENOM" id="CLU_028255_0_1_6"/>
    <dbReference type="OMA" id="YTAVHEK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="408" mass="42014" checksum="B9B810EE938CD995" modified="2005-12-06" version="1">MAYCNPGLESGPNKRNALRRHVVTGIGMKIVIAPDSYKESLSASEVAQAIEKGFREIFPDAQYVSVPVADGGEGTVEAMIAATQGSERHAWVTGPLGEKVNASWGISGDGKTAFIEMAAASGLELVPAEKRDPLVTTSRGTGELILQALESGATNIIIGIGGSATNDGGAGMVQALGAKVCDANGNEIGFGGGSLNTLNDIDISGLDPRLKDCVIRVACDVTNPLVGDNGASRIFGPQKGASEAMIVELDNNLSHYAEVIKKALHVDVKDVPGAGAAGGMGAALMAFLGAELKSGIEIVTTALNLEEHIHDCTLVITGEGRIDSQSIHGKVPIGVANVAKKYHKPVIGIAGSLTDDVGVVHQHGIDAVFSVLTSIGTLEEAFRGAYDNICRASRNIAATLAIGMRNAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-03-21" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BS6</accession>
    <name>FTSP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein FtsP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ftsP</name>
        <name type="ordered locus">SDY_3220</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
        <text evidence="1">Localizes to the division septum.</text>
    </comment>
    <comment type="PTM">
        <text>Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000059377.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404720.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BS6"/>
    <dbReference type="SMR" id="Q32BS6"/>
    <dbReference type="STRING" id="300267.SDY_3220"/>
    <dbReference type="EnsemblBacteria" id="ABB63229">
        <property type="protein sequence ID" value="ABB63229"/>
        <property type="gene ID" value="SDY_3220"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3220"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3845"/>
    <dbReference type="HOGENOM" id="CLU_009100_2_4_6"/>
    <dbReference type="OMA" id="GMWIIED"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00915">
        <property type="entry name" value="FtsP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026589">
        <property type="entry name" value="FtsP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" description="Tat-type signal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000416014" description="Cell division protein FtsP">
        <location>
            <begin position="28"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="1">
        <location>
            <begin position="229"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00915"/>
        </source>
    </evidence>
    <sequence length="470" mass="51778" checksum="E4764B70A8E1FE5B" modified="2005-12-06" version="1" precursor="true">MSLSRRQFIQASGIALCAGAVPLKASAAGQQQPLPVPPLLESRRGQPLFMTVQRAHWSFTLGTRASVWGINGSYLGPTIRVWKGDDVKLIYSNRLTENVSMTVAGLQVPGPLMGGPARMMSPNADWAPVLPIRQNAATLWYHANTPNRTAQQVYNGLAGMWLVEDEVSKSLPIPNHYGVDDFPVIIQDKRLDNFGTPEYNEPGSGGFVGDTLLVNGVQSPYVEVSRGWVRLRLLNASNSRRYQLQMSDGRPLHVISGDQGFLPAPVSVKQLSLAPGERREILVDMSNGDEVSITCGEAASIVDRIRGFFEPSSILVSTLVLTLRPTGLLPLVTDSLPMRLLPTEIMAGSPIRSRDISLGDDPGINGQLWDVNRIDVTAQQGTWERWTVRADEPQAFHIEGVMFQIRNVNGAMPFPEDRGWKDTVWVDGQVELLVYFGQPSWAHFPFYFNSQTLEMADRGSIGQLLVNPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BT1</accession>
    <name>Q32BT1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BOF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ygiW</name>
        <name evidence="4" type="ordered locus">SDY_3215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000712658.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404715.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BT1"/>
    <dbReference type="SMR" id="Q32BT1"/>
    <dbReference type="STRING" id="300267.SDY_3215"/>
    <dbReference type="EnsemblBacteria" id="ABB63224">
        <property type="protein sequence ID" value="ABB63224"/>
        <property type="gene ID" value="SDY_3215"/>
    </dbReference>
    <dbReference type="GeneID" id="66673085"/>
    <dbReference type="KEGG" id="sdy:SDY_3215"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3840"/>
    <dbReference type="HOGENOM" id="CLU_118907_1_0_6"/>
    <dbReference type="OMA" id="KHLMSRE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036700">
        <property type="entry name" value="BOBF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005220">
        <property type="entry name" value="BOF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016052">
        <property type="entry name" value="YgiW/YdeI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04076">
        <property type="entry name" value="BOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101756">
        <property type="entry name" value="SSF101756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00156">
        <property type="entry name" value="TIGR00156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221016" description="BOF domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="BOF" evidence="3">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="130" mass="14011" checksum="EEF2F415058CA428" modified="2005-12-06" version="1">MKKFAAVIAVMALCSAPVMAAEQGGFSGPSATQSQAGGFQGPNGSVTTVESAKSLRDDTWVTLRGNIVERISDDLYVFKDASGTINVDIDHKRWNGVTVTPKDTVEIQGEVDKDWNSVEIDVKQIRKVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BT3</accession>
    <name>Q32BT3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sensor protein QseC</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">qseC</name>
        <name evidence="12" type="ordered locus">SDY_3213</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000673359.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404713.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BT3"/>
    <dbReference type="STRING" id="300267.SDY_3213"/>
    <dbReference type="EnsemblBacteria" id="ABB63222">
        <property type="protein sequence ID" value="ABB63222"/>
        <property type="gene ID" value="SDY_3213"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3213"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3838"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_37_6"/>
    <dbReference type="OMA" id="DKLFDTQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013727">
        <property type="entry name" value="2CSK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08521">
        <property type="entry name" value="2CSK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="243"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="449" mass="50304" checksum="5428374FDAAE2847" modified="2005-12-06" version="1">MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLKHGHVDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGDKDQWRFVWMTSPDGKYRIVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHYGIDRATRLVDQLLTLSRLDSLDNLQDVAESPLEDLLQSSVMDIYHTAQQAKIDVRLTLNVQGIKRTGQPLLLSLLVRNLLDNAVHYSPQGSVVDVTLNADNFIVRDNGPGVTPEALARIGERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C28</accession>
    <name>Q32C28_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yggL</name>
        <name evidence="1" type="ordered locus">SDY_3113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C28"/>
    <dbReference type="STRING" id="300267.SDY_3113"/>
    <dbReference type="EnsemblBacteria" id="ABB63127">
        <property type="protein sequence ID" value="ABB63127"/>
        <property type="gene ID" value="SDY_3113"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3113"/>
    <dbReference type="HOGENOM" id="CLU_153063_1_0_6"/>
    <dbReference type="OMA" id="PLLDVWY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007416">
        <property type="entry name" value="YggL_50S_bp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38778">
        <property type="entry name" value="PTHR38778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04320">
        <property type="entry name" value="YggL_50S_bp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="118" mass="13980" checksum="2BD370DC2AE9FA09" modified="2005-12-06" version="1">MGLNVREGEIMAKNRSRRLRKKMHIDEFQELGFSVAWRFPEGTSEEQIDKTVDDFINEVIEPNKLAFDGSGYLAWEGLICMQEIGKCTEEHQAIVRKWLEERKLDEVRTSELFDVWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C51</accession>
    <name>Q32C51_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_3088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404595.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C51"/>
    <dbReference type="STRING" id="300267.SDY_3088"/>
    <dbReference type="EnsemblBacteria" id="ABB63104">
        <property type="protein sequence ID" value="ABB63104"/>
        <property type="gene ID" value="SDY_3088"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3088"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3695"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="OMA" id="TAGHQHY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="9978" checksum="E880C1197AD575CE" modified="2005-12-06" version="1">MASVSISCPSCSATDGVVRNGKSTARHQHYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVSLNTILRHLKNSGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C54</accession>
    <name>Q32C54_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathionylspermidine synthetase/amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gsp</name>
        <name evidence="3" type="ordered locus">SDY_3085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the glutathionylspermidine synthase preATP-grasp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001297309.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404592.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C54"/>
    <dbReference type="SMR" id="Q32C54"/>
    <dbReference type="STRING" id="300267.SDY_3085"/>
    <dbReference type="EnsemblBacteria" id="ABB63101">
        <property type="protein sequence ID" value="ABB63101"/>
        <property type="gene ID" value="SDY_3085"/>
    </dbReference>
    <dbReference type="GeneID" id="66673115"/>
    <dbReference type="KEGG" id="sdy:SDY_3085"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3692"/>
    <dbReference type="HOGENOM" id="CLU_478805_0_0_6"/>
    <dbReference type="OMA" id="YMGYKWQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="34"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="619" mass="70532" checksum="07FB43D8A0B2933C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CB1</accession>
    <name>Q32CB1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ygdD</name>
        <name evidence="7" type="ordered locus">SDY_3025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0382 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000203905.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404535.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CB1"/>
    <dbReference type="STRING" id="300267.SDY_3025"/>
    <dbReference type="EnsemblBacteria" id="ABB63044">
        <property type="protein sequence ID" value="ABB63044"/>
        <property type="gene ID" value="SDY_3025"/>
    </dbReference>
    <dbReference type="GeneID" id="66673326"/>
    <dbReference type="KEGG" id="sdy:SDY_3025"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3631"/>
    <dbReference type="HOGENOM" id="CLU_096548_3_2_6"/>
    <dbReference type="OMA" id="QFYHTFA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="PTHR43461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="14333" checksum="2EE9FD9B596012DD" modified="2005-12-06" version="1">MTSRFMLIFAAISGFIFVALGAFGAHVLSKTMGAVEMGWIQTGLEYQAFHTLAILGLAVAMQRRISIWFYWSSVFLALGTVLFSGSLYCLALSHLRLWAFVTPVGGVSFLAGWALMLVGAIRLKRKGVSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CD7</accession>
    <name>Q32CD7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404509.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CD7"/>
    <dbReference type="STRING" id="300267.SDY_2995"/>
    <dbReference type="EnsemblBacteria" id="ABB63018">
        <property type="protein sequence ID" value="ABB63018"/>
        <property type="gene ID" value="SDY_2995"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2995"/>
    <dbReference type="HOGENOM" id="CLU_189815_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="88" mass="8968" checksum="A8DD0B85A977B417" modified="2005-12-06" version="1">MVFLYVAEPGPWTNLIVACGMLTPFAIVPLVIFWLIVNKKLRAKYKKLSKERASRKGSSSSSSGGGSSGGGFSGGGGSSGGGGASGRW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CW9</accession>
    <name>SSRP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smpB</name>
        <name type="ordered locus">SDY_2793</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000162574.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404327.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CW9"/>
    <dbReference type="SMR" id="Q32CW9"/>
    <dbReference type="STRING" id="300267.SDY_2793"/>
    <dbReference type="EnsemblBacteria" id="ABB62836">
        <property type="protein sequence ID" value="ABB62836"/>
        <property type="gene ID" value="SDY_2793"/>
    </dbReference>
    <dbReference type="GeneID" id="67414063"/>
    <dbReference type="KEGG" id="sdy:SDY_2793"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3365"/>
    <dbReference type="HOGENOM" id="CLU_108953_3_0_6"/>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_1000002147" description="SsrA-binding protein">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <sequence length="160" mass="18269" checksum="F7E45A16540EA300" modified="2005-12-06" version="1">MTKKKAHKPGSATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANISDSYVLLRDGEAFLFGANITPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRVNREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRSDIKEREWQVDKARIMKNAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CX1</accession>
    <name>Q32CX1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0125 protein SDY_2791</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0125 (RnfH) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CX1"/>
    <dbReference type="STRING" id="300267.SDY_2791"/>
    <dbReference type="EnsemblBacteria" id="ABB62834">
        <property type="protein sequence ID" value="ABB62834"/>
        <property type="gene ID" value="SDY_2791"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2791"/>
    <dbReference type="HOGENOM" id="CLU_150721_1_1_6"/>
    <dbReference type="OMA" id="DMIHVEV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00460">
        <property type="entry name" value="UPF0125_RnfH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005346">
        <property type="entry name" value="RnfH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037021">
        <property type="entry name" value="RnfH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37483">
        <property type="entry name" value="PTHR37483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03658">
        <property type="entry name" value="Ub-RnfH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="102" mass="11591" checksum="2A1D9B6DD5410664" modified="2005-12-06" version="1">MRKRFTVPGKIAVEVAYALPEKQYLQRVTLQEGATVEEAIRASGLLELRTDIDLTKNKVGIYSRPAKLSDSVHDGDRVEIYRPLIAEPKELRRQRAEKSANK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CY2</accession>
    <name>RL19_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplS</name>
        <name type="ordered locus">SDY_2780</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000065253.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404314.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CY2"/>
    <dbReference type="SMR" id="Q32CY2"/>
    <dbReference type="STRING" id="300267.SDY_2780"/>
    <dbReference type="EnsemblBacteria" id="ABB62823">
        <property type="protein sequence ID" value="ABB62823"/>
        <property type="gene ID" value="SDY_2780"/>
    </dbReference>
    <dbReference type="GeneID" id="67414076"/>
    <dbReference type="KEGG" id="sdy:SDY_2780"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3351"/>
    <dbReference type="HOGENOM" id="CLU_103507_2_1_6"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000226872" description="50S ribosomal protein L19">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <sequence length="115" mass="13133" checksum="7BD9F2EFB9DDB06B" modified="2005-12-06" version="1">MSNIIKQLEQEQMKQDVPSFRPGDTVEVKVWVVEGSKKRLQAFEGVVIAIRNRGLHSAFTVRKISNGEGVERVFQTHSPVVDSISVKRRGAVRKAKLYYLRERTGKAARIKERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CY4</accession>
    <name>Q32CY4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
            <ecNumber evidence="2">2.7.7.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yfiN</name>
        <name evidence="8" type="ordered locus">SDY_2778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
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    <sequence length="265" mass="29977" checksum="6E0B703C3F8952C3" modified="2005-12-06" version="1">MANARDSSISHFIWFSLAVLTGCILLASGIAITLTRHLHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAQNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFIDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR</sequence>
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<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
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                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="526" mass="56671" checksum="D798515B507DAD8F" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DC9</accession>
    <name>Q32DC9_SHIDS</name>
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        <submittedName>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
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                <person name="Yan Y."/>
                <person name="Tang X."/>
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                <person name="Xiong Z."/>
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                <person name="Xue Y."/>
                <person name="Zhu Y."/>
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                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
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                <person name="Hou Y."/>
                <person name="Yu J."/>
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            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <comment type="subcellular location">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="25"/>
        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="338" mass="37672" checksum="FFABE6A187091852" modified="2005-12-06" version="1">MAVNLLKKNSLALVASLLLAGHVQATELLNSSYDVSRELFAALNPPFEQQWAKDNGGDKLTIKQSHAGSSKQALAILQGLKADVVTYNQVTDVQILHDKGKLIPADWQSRLPNNSSPFYSTMGFLVRKGNPKNIHDWNDLVRSDVKLIFPNPKTSGNARYTYLAAWGSVDKADGGDKAKTEQFMTQFLKNVEVFDTGGRGATTTFAERGLGDVLISFESEVNNIRKQYEAQGFEVVIPKTNILAEFPVAWVDKNVQANGTEKAAKAYLNWLYSPQAQTIITDYYYRVNNPEVMDKLKNKFPQTELFRVEDKFGSWPEVMKTHFTSGGELDKLLAAGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DE4</accession>
    <name>Q32DE4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytochrome oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yfeH</name>
        <name evidence="3" type="ordered locus">SDY_2606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000765591.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404152.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DE4"/>
    <dbReference type="STRING" id="300267.SDY_2606"/>
    <dbReference type="EnsemblBacteria" id="ABB62661">
        <property type="protein sequence ID" value="ABB62661"/>
        <property type="gene ID" value="SDY_2606"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2606"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3143"/>
    <dbReference type="HOGENOM" id="CLU_039013_1_0_6"/>
    <dbReference type="OMA" id="IYQRVFM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="PTHR18640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="332" mass="36376" checksum="00797C4BB4060403" modified="2005-12-06" version="1">MKLFRILDPFTLTLITVVLLASFFPARGDFVPFFENLTTAAIALLFFMHGAKLSREAIIAGGGHWRLHLWVMCSTFVLFPILGVLFARWKPVNVDPMLYSGFLYLCILPATVQSAIAFTSMAGGNVAAAVCSASASSLLGIFLSPLLVGLVMNVHGAGGSLEQVGKIMLQLLLPFVLGHLSRPWIGDWVSRNKKWIAKTDQTSILLVVYTAFSEAVVNGIWHKVGWGSLLFIVVVSCVLLAIVIVVNVFMARRLGFNKADEITIVFCGSKKSLANGIPMANILFPTSVIGMMVLPLMIFHQIQLMVCAVLARRYKRQTEQLQAQQESSTDKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DG9</accession>
    <name>FCTA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Formyl-CoA:oxalate CoA-transferase</fullName>
            <shortName>FCOCT</shortName>
            <ecNumber evidence="2">2.8.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Formyl-coenzyme A transferase</fullName>
            <shortName evidence="2">Formyl-CoA transferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">frc</name>
        <name type="ordered locus">SDY_2572</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>formyl-CoA + oxalate = formate + oxalyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:16545"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:57388"/>
            <dbReference type="EC" id="2.8.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate degradation; oxalate degradation; CO(2) and formate from oxalate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CoA-transferase III family. Frc subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000106757.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404127.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DG9"/>
    <dbReference type="SMR" id="Q32DG9"/>
    <dbReference type="STRING" id="300267.SDY_2572"/>
    <dbReference type="EnsemblBacteria" id="ABB62636">
        <property type="protein sequence ID" value="ABB62636"/>
        <property type="gene ID" value="SDY_2572"/>
    </dbReference>
    <dbReference type="GeneID" id="58463048"/>
    <dbReference type="KEGG" id="sdy:SDY_2572"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3102"/>
    <dbReference type="HOGENOM" id="CLU_033975_2_1_6"/>
    <dbReference type="OMA" id="KFDIPCA"/>
    <dbReference type="UniPathway" id="UPA00540">
        <property type="reaction ID" value="UER00598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033608">
        <property type="term" value="F:formyl-CoA transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033611">
        <property type="term" value="P:oxalate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00742">
        <property type="entry name" value="Formyl_CoA_transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017659">
        <property type="entry name" value="Formyl_CoA_transfer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03253">
        <property type="entry name" value="oxalate_frc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000300995" description="Formyl-CoA:oxalate CoA-transferase">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="72"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="248"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="273"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00742"/>
        </source>
    </evidence>
    <sequence length="416" mass="45814" checksum="9702FBF0010732B1" modified="2005-12-06" version="1">MSTPLQGIKVLDFTGVQSGPSCTQMLAWFGADVIKIERPGVGDVTRHQLRDIPDIDALYFTMLNSNKRSIELNTKTAEGKEVMEKLIREADILVENFHPGAIDHMGFTWEHIQEINPRLIFGSIKGFDECSPYVNVKAYENVAQAAGGAASTTGFWDGPPLVSAAALGDSNTGMHLLIGLLAALLHREKTGRGQRVTMSMQDAVLNLCRVKLRDQQRLDKLGYLEEYPQYPNGTFGDAVPRGGNAGGGGQPGWILKCKGWETDPNAYIYFTIQEQNWENTCKAIGKPDWITDPAYSTAHARQPHIFDIFAEIEKYTVTIDKHEAVAYLTQFDIPCAPVLSMKEISLDPSLRQSGSVVEVEQPLRGKYLTVGCPMKFSAFTPDIKAAPLLGEHTAAVLQELGYSDDEIAAMKQNHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DH2</accession>
    <name>Q32DH2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfdE</name>
        <name evidence="1" type="ordered locus">SDY_2569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404124.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DH2"/>
    <dbReference type="STRING" id="300267.SDY_2569"/>
    <dbReference type="EnsemblBacteria" id="ABB62633">
        <property type="protein sequence ID" value="ABB62633"/>
        <property type="gene ID" value="SDY_2569"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2569"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3099"/>
    <dbReference type="HOGENOM" id="CLU_033975_0_0_6"/>
    <dbReference type="OMA" id="NRERHGV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="394" mass="43436" checksum="605FB358D532BC16" modified="2005-12-06" version="1">MSFHLRLFSRHKQMTNNESKGPFEGLLVIDMTHVLNGPFGTQLLCNMGARVIKVEPPGHGDDTRTFGPYVDGQSLYYSFINHGKESVVLDLKNDHDKRIFINMLKQADVLAENFRPGTMEKLGFSWERLQEINPRLIYASSSGFGHTGPLKDAPAYDTIIQAMSGIMMETGYPDAPPVRVGTSLADLCGGVYLFSGIVSALYGREKSQRGARVDIAMFDATLSFLEHGLMAYIATGKSPQRLGNRHPYMAPFDVFDTQDKPITICCGNDKLFSALCQALELTELVNAPRFSSNILRVQNQAILKQYIERTLKTQAAEVWLARIHEVGVPVAPLLSVAEAINLPQTQARNMLIEAGGIMMPGNPIKISGCADPHVMPGAATLDQHGEQIRQEFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DJ9</accession>
    <name>Q32DJ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative fimbrial usher</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SDY_2537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell outer membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the fimbrial export usher family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DJ9"/>
    <dbReference type="STRING" id="300267.SDY_2537"/>
    <dbReference type="EnsemblBacteria" id="ABB62606">
        <property type="protein sequence ID" value="ABB62606"/>
        <property type="gene ID" value="SDY_2537"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2537"/>
    <dbReference type="HOGENOM" id="CLU_009120_0_4_6"/>
    <dbReference type="OMA" id="GANWGAW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015473">
        <property type="term" value="F:fimbrial usher porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000015">
        <property type="entry name" value="Fimb_usher"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018030">
        <property type="entry name" value="Fimbrial_membr_usher_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025885">
        <property type="entry name" value="PapC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037224">
        <property type="entry name" value="PapC_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30451">
        <property type="entry name" value="PTHR30451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13954">
        <property type="entry name" value="PapC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00577">
        <property type="entry name" value="Usher"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141729">
        <property type="entry name" value="SSF141729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01151">
        <property type="entry name" value="FIMBRIAL_USHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="9" id="KW-1029">Fimbrium biogenesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PapC_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="576" mass="64182" checksum="E1C7B2DC3457AD3D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DS1</accession>
    <name>Q32DS1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">elaA</name>
        <name evidence="2" type="ordered locus">SDY_2463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000574087.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404025.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DS1"/>
    <dbReference type="STRING" id="300267.SDY_2463"/>
    <dbReference type="EnsemblBacteria" id="ABB62534">
        <property type="protein sequence ID" value="ABB62534"/>
        <property type="gene ID" value="SDY_2463"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2463"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2970"/>
    <dbReference type="HOGENOM" id="CLU_056607_3_1_6"/>
    <dbReference type="OMA" id="VVEQDCV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="153" mass="17420" checksum="66C3457D003E1CA0" modified="2005-12-06" version="1">MIEWQDLHHSELSVSQLYALLQLRCAVFVVEQNCPYQDIDGDDLTGDNRHILGWKNDELVAYARILKSDDDLEPVVIGRVIVSEALRGEKVGQQLMSKTLDTCTHHWPDKPVYLGAQAHLQNFYQSFGFIPVTEIYEEDGIPHIGMAREVIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DZ7</accession>
    <name>Q32DZ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybjX</name>
        <name evidence="1" type="ordered locus">SDY_2384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403949.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DZ7"/>
    <dbReference type="STRING" id="300267.SDY_2384"/>
    <dbReference type="EnsemblBacteria" id="ABB62458">
        <property type="protein sequence ID" value="ABB62458"/>
        <property type="gene ID" value="SDY_2384"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2384"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2877"/>
    <dbReference type="HOGENOM" id="CLU_065818_1_0_6"/>
    <dbReference type="OMA" id="RRYEWLD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007488">
        <property type="entry name" value="DUF535"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38785">
        <property type="entry name" value="PTHR38785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04393">
        <property type="entry name" value="DUF535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="330" mass="38253" checksum="9DE3BDFAF30B3704" modified="2005-12-06" version="1">MVKSTSCTTIDFMNMSQLTERTFTSSESLSSLSLFLSLARGQCRPGKFWHRRSFRQKFLLRSLIMPRLSVEWMNELSHWPNLNVLLTRQPRLPVRLHRPYLAANLSRKQLLEALRYHYALLRGCMSAEEFSLYLNTPGLQLAKLEGKNGEQFTLELTMMISMDKEGDSTILFRNSEGIPLAELTFTLCEYQGKRTMFIGGLQGAKWEIPHQEIQNATKACHGLFPKRLVMEAACLFAQRLQVEQIIAVSNETHIYRSLRYRDKEGKIHADYNAFWESVGGVCDAERHYRLPAQIARKEIAEIASKKRAEYRRRYEMLDAIQPQMATMFRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E52</accession>
    <name>PNCB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nicotinate phosphoribosyltransferase</fullName>
            <shortName evidence="1">NAPRTase</shortName>
            <ecNumber evidence="1">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pncB</name>
        <name type="ordered locus">SDY_2326</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021568.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403894.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E52"/>
    <dbReference type="SMR" id="Q32E52"/>
    <dbReference type="STRING" id="300267.SDY_2326"/>
    <dbReference type="EnsemblBacteria" id="ABB62403">
        <property type="protein sequence ID" value="ABB62403"/>
        <property type="gene ID" value="SDY_2326"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2326"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2808"/>
    <dbReference type="HOGENOM" id="CLU_030991_1_0_6"/>
    <dbReference type="OMA" id="QAVFHRY"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01401">
        <property type="entry name" value="PncB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00570">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000025012" description="Nicotinate phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00570"/>
        </source>
    </evidence>
    <sequence length="400" mass="45926" checksum="2B5C5AB09FACC571" modified="2005-12-06" version="1">MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVHVAAEFRCRGDDLLGIYADAIREQVQAMQHLRLQDDEYQWLSALPFFKADYLNWLRKFRFNPEQVTVSNDNGKLDIRLSGPWREVILWEVPLLAVISEMVHRYRSPQADVAQALDTLESKLVDFSALTAGLDMSRFHLMDFGTRRRFSREVQETIVKRLQQESWFVGTSNYDLARRLSLTPMGTQAHEWFQAHQQISPDLANSQRAALAAWLEEYPDQLGIALTDCITMDAFLRDFGVEFASRYQGLRHDSGDPVEWGEKAIAHYEKLGIDPQSKTLVFSDNLDLRKAVELYRHFSSRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPSKTICHDKAFVRALRKAFDLPHIKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E81</accession>
    <name>Q32E81_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yceE</name>
        <name evidence="8" type="ordered locus">SDY_2297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403865.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E81"/>
    <dbReference type="STRING" id="300267.SDY_2297"/>
    <dbReference type="EnsemblBacteria" id="ABB62374">
        <property type="protein sequence ID" value="ABB62374"/>
        <property type="gene ID" value="SDY_2297"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2297"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2774"/>
    <dbReference type="HOGENOM" id="CLU_001265_57_3_6"/>
    <dbReference type="OMA" id="VIRHNVP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="323" mass="34520" checksum="4B3FDE911F971131" modified="2005-12-06" version="1">MLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPMAGGLLADSYGLRPVFFITASVLILCFFVTLFCIREKFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNVAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKLLITALIFSVLLLIPMSYVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRRRRIPQISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EN5</accession>
    <name>Q32EN5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-galactose-binding periplasmic protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">D-galactose/ D-glucose-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mglB</name>
        <name evidence="12" type="ordered locus">SDY_2130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001036964.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403711.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EN5"/>
    <dbReference type="SMR" id="Q32EN5"/>
    <dbReference type="STRING" id="300267.SDY_2130"/>
    <dbReference type="EnsemblBacteria" id="ABB62220">
        <property type="protein sequence ID" value="ABB62220"/>
        <property type="gene ID" value="SDY_2130"/>
    </dbReference>
    <dbReference type="GeneID" id="66673954"/>
    <dbReference type="KEGG" id="sdy:SDY_2130"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2569"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_1_6"/>
    <dbReference type="OMA" id="MWDAAMA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01539">
        <property type="entry name" value="PBP1_GGBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044085">
        <property type="entry name" value="MglB-like_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221081" description="D-galactose-binding periplasmic protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="11">
        <location>
            <begin position="28"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="332" mass="35713" checksum="9A57E86C423AA6D3" modified="2005-12-06" version="1">MNKKVLTLSAVMASMLFGAAAHAADTRIGVTIYKYDDNFMSVVRKAIEQDAKAAPDVQLLMNDSQNDQSKQNDQIDVLLAKGVKALAINLVDPAAAGTVIEKARGQNVPVVFFNKEPSRKALDSYDKAYYVGTDSKESGIIQGDLIAKHWAANQGWDLNKDGQIQFVLLKGEPGHPDAEARTTYVIKELNDKGIKTEQLQLDTAMWDTAQAKDKMDAWLSGPNANKIEVVIANNDAMAMGAVEALKAHNKSSIPVFGVDALPEALALVKSGALAGTVLNDANNQAKATFDLAKNLADGKGAADGTNWKIDNKVVRVPYVGVDKDNLAEFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F44</accession>
    <name>Q32F44_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSS-motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F44"/>
    <dbReference type="STRING" id="300267.SDY_1960"/>
    <dbReference type="EnsemblBacteria" id="ABB62061">
        <property type="protein sequence ID" value="ABB62061"/>
        <property type="gene ID" value="SDY_1960"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1960"/>
    <dbReference type="HOGENOM" id="CLU_1010148_0_0_6"/>
    <dbReference type="OMA" id="WHGTIFQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024744">
        <property type="entry name" value="CSS-motif_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12792">
        <property type="entry name" value="CSS-motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CSS-motif" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="226" mass="24739" checksum="B91AF2E87AA49768" modified="2005-12-06" version="1">MLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSNAGVMEMINIDLLTAMLLEPQLPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQRFPFTINVNGPGATALAWHYLPTQLPLAVLLSLLAGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F74</accession>
    <name>Q32F74_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Repressor protein CI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001056251.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403522.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F74"/>
    <dbReference type="MEROPS" id="S24.002"/>
    <dbReference type="EnsemblBacteria" id="ABB62031">
        <property type="protein sequence ID" value="ABB62031"/>
        <property type="gene ID" value="SDY_1925"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1925"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2321"/>
    <dbReference type="HOGENOM" id="CLU_066192_1_3_6"/>
    <dbReference type="OMA" id="KWIALVR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="26357" checksum="FE7812E079C83216" modified="2005-12-06" version="1">MNMKKKPLTPEQLEDAKRLKSIFNAKKKELGLSQESLAYELGVTQSAVSQLMAGINAINASHAAQLAKILNVKVGDFSPSLAKSIAEMALAIEEPLTRVPAYEYPLLSCVQAGAFSMDDISYTAKDAIKWISTTTKASDRSFWLEVKGHSMTAPQGGKPSFPEGMLILVDPEREIEDGDFCVARMNGDEFTFKRFIRESGKAYLEPLNPRFDMIECNENCQFVGKVIKSQWNDETFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FA0</accession>
    <name>Q32FA0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase, Fe-S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403496.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FA0"/>
    <dbReference type="STRING" id="300267.SDY_1899"/>
    <dbReference type="EnsemblBacteria" id="ABB62005">
        <property type="protein sequence ID" value="ABB62005"/>
        <property type="gene ID" value="SDY_1899"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1899"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2284"/>
    <dbReference type="HOGENOM" id="CLU_043374_1_3_6"/>
    <dbReference type="OMA" id="EKCTWCY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="239" mass="26883" checksum="0DC8E92F62824977" modified="2005-12-06" version="1">MSWIGWTVAATALGDNQMSFTRRKFVLGMGTVIFFTGSASSLLANTRQEKEVRYAMIHDESRCNGCNICARACRKTNHVPAQGSRLSIAHIPVTDNDNETQYHFFRQSCQHCEDAPCIDVCPTGASWRDEQGIVRVEKSQCIGCSYCIGACPYQVRYLNPVTKVADKCDFCAESRLAKGFPPICVSACPEHALIFGREDSPEIQAWLQDNKYYQYQLPGAGKPHLYRRFGQHLIKKENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FC0</accession>
    <name>Q32FC0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-ethylmaleimide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nemA</name>
        <name evidence="2" type="ordered locus">SDY_1876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FC0"/>
    <dbReference type="STRING" id="300267.SDY_1876"/>
    <dbReference type="EnsemblBacteria" id="ABB61985">
        <property type="protein sequence ID" value="ABB61985"/>
        <property type="gene ID" value="SDY_1876"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1876"/>
    <dbReference type="HOGENOM" id="CLU_012153_0_2_6"/>
    <dbReference type="OMA" id="MQIMHGG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="343" mass="37242" checksum="B47563E111EFA238" modified="2005-12-06" version="1">MAPLTRLRSIEPGDIPTPLMAEYYRQRASAGLIISEATQISAQAKGYAGAPGIHSPEQIAAWKKITAGVHAENGHMAVQLWHTGRISHASLQLGGQAPVAPSALSAGTRTSLRDENGQAIRVETSMPRALELEEIPGIVNDFRQAIANARETGFDLVELHSAHGYLLHQFLSPSSNHRTDQYGGSVENRARLVLEVVDAGIEEWGADRIGIRVSPIGTFQNTDNGPNEEADALYLIEQLGKRGIAYLHMSEPDWAGGEPYTDAFREKVRARFHDPIIGAGAYTVEKAETLIGKGLIDAVAFGRDWIANPDLVARLQRKAELNPQRAESFYGGGAEGYTDYPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FQ9</accession>
    <name>Q32FQ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001076550.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403337.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FQ9"/>
    <dbReference type="STRING" id="300267.SDY_1726"/>
    <dbReference type="EnsemblBacteria" id="ABB61846">
        <property type="protein sequence ID" value="ABB61846"/>
        <property type="gene ID" value="SDY_1726"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1726"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2081"/>
    <dbReference type="HOGENOM" id="CLU_111581_0_0_6"/>
    <dbReference type="OMA" id="ISGYQYV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="149" mass="15853" checksum="40E551C0A21E9430" modified="2005-12-06" version="1">MNQSLTLAFLIAAGIGLVVQNTLMVRITQTSSTILIAMLLNSLVGIVLFVSILWFKQGMAGFGELVSSVRWWTLIPSLLGSFFVFASISGYQNVGAATTIAVLVASQLIGGLVLDIFRSHGVPLRALFGPICGAILLVVGAWLVARRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FR2</accession>
    <name>Q32FR2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403334.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FR2"/>
    <dbReference type="STRING" id="300267.SDY_1723"/>
    <dbReference type="EnsemblBacteria" id="ABB61843">
        <property type="protein sequence ID" value="ABB61843"/>
        <property type="gene ID" value="SDY_1723"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1723"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2078"/>
    <dbReference type="HOGENOM" id="CLU_172440_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="103" mass="11437" checksum="89019951819A6629" modified="2005-12-06" version="1">MPRTGKMKHVSLTLQVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLISVNALSVTPAQAFTVPEVGNDSNLLIVFYVQIMPDDFVMQLHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FS3</accession>
    <name>Q32FS3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000128816.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403323.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FS3"/>
    <dbReference type="STRING" id="300267.SDY_1712"/>
    <dbReference type="EnsemblBacteria" id="ABB61832">
        <property type="protein sequence ID" value="ABB61832"/>
        <property type="gene ID" value="SDY_1712"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1712"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2066"/>
    <dbReference type="HOGENOM" id="CLU_012117_2_0_6"/>
    <dbReference type="OMA" id="KIIVVNH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="636" mass="70395" checksum="1342CDC93CA4C349" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FT2</accession>
    <name>Q32FT2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_1702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403314.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FT2"/>
    <dbReference type="STRING" id="300267.SDY_1702"/>
    <dbReference type="EnsemblBacteria" id="ABB61823">
        <property type="protein sequence ID" value="ABB61823"/>
        <property type="gene ID" value="SDY_1702"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1702"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2054"/>
    <dbReference type="HOGENOM" id="CLU_2737819_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="7457" checksum="26672B615A74A83A" modified="2005-12-06" version="1">MMSNVKKKDVPLISISLVAILFIAAALSLFPEQSADAANAIYTFVTRTLGSAVQVLVLLAMGLVIYGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FX7</accession>
    <name>Q32FX7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403269.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FX7"/>
    <dbReference type="STRING" id="300267.SDY_1657"/>
    <dbReference type="EnsemblBacteria" id="ABB61778">
        <property type="protein sequence ID" value="ABB61778"/>
        <property type="gene ID" value="SDY_1657"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1657"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1998"/>
    <dbReference type="HOGENOM" id="CLU_080390_0_0_6"/>
    <dbReference type="OMA" id="MSQHISC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10466">
        <property type="entry name" value="FimH_man-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015243">
        <property type="entry name" value="FimH_man-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09160">
        <property type="entry name" value="FimH_man-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FimH_man-bind" evidence="1">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="225" mass="23840" checksum="0A5E7A3DDE2AC5AA" modified="2005-12-06" version="1">MKNTCSTNWKHHQSYKGSLYWNNVTYPFPLTTNTNVLDIGDKTPMPLPLKLYITPVGAAGGVVIKAGEVIARIHMYKIATLGSGNPRNFTWNIISNNSVVMPTGGCTVDSRNVTVNLPDFPGSAEIPLGVYCSSEQKLSFYLSGATTDSARQVFANTAPDATKASGVGVSLMRNGKILATGENVSLGTVNKSKVPLGLSATYGQTGNKVSAGTVQSVIGVTFIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G41</accession>
    <name>Q32G41_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ydfH</name>
        <name evidence="5" type="ordered locus">SDY_1585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000215556.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403205.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G41"/>
    <dbReference type="STRING" id="300267.SDY_1585"/>
    <dbReference type="EnsemblBacteria" id="ABB61714">
        <property type="protein sequence ID" value="ABB61714"/>
        <property type="gene ID" value="SDY_1585"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1585"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1904"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_2_6"/>
    <dbReference type="OMA" id="AWDTVEN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="228" mass="26581" checksum="8CECAF8C9C35AE64" modified="2005-12-06" version="1">MTVETQLNPTQPVNQQIYRILRRDIVHCLIAPGTPLSEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVNKISMSQVRNGSFIRQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERKQLDDFFELDDNFHQLLTQIADCQLAWDTIENLKATVDRVRYMSFDHVSPPEMLLRQHLDIFSALQKRDGDAVERAMTQHLQEISESVRQIRQENSDWFSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G58</accession>
    <name>Q32G58_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator LYSR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ynfL</name>
        <name evidence="3" type="ordered locus">SDY_1561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001019523.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403188.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G58"/>
    <dbReference type="STRING" id="300267.SDY_1561"/>
    <dbReference type="EnsemblBacteria" id="ABB61697">
        <property type="protein sequence ID" value="ABB61697"/>
        <property type="gene ID" value="SDY_1561"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1561"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1871"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_6"/>
    <dbReference type="OMA" id="GKQPELC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="297" mass="33383" checksum="A8D76DA83FDAF794" modified="2005-12-06" version="1">MNIELRHLRYFVAVAEELHFGRAAARLNISQPPLSQQIQALEQQIGARLLARTNRSVLLTAAGKQFLADSRQILSMVDDAAARAERLHQGEAGELRIGFTSSAPFIRAVSDTLSLFRRDYPDVHLQTREMNTREQIAPLIEGTLDMGLLRNTALPDTLEHTVIVHEPLMEMIPHEHPLANNPNVTLAELAKEPFVFFDPHVGTGLYDDILGLMRRYHLTPVITQEVGEAMTIIGLVSAGLGVSILPASFKRVQLNEMRWVPIAEEDAVSEMWLVWPKHHEQSPAARNFRIHLLNALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GF5</accession>
    <name>Q32GF5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403091.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GF5"/>
    <dbReference type="EnsemblBacteria" id="ABB61600">
        <property type="protein sequence ID" value="ABB61600"/>
        <property type="gene ID" value="SDY_1460"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1460"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1739"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="MVAHIRT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27495" checksum="0C8DBD62BA8754B5" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHHMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GH3</accession>
    <name>Q32GH3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GH3"/>
    <dbReference type="EnsemblBacteria" id="ABB61582">
        <property type="protein sequence ID" value="ABB61582"/>
        <property type="gene ID" value="SDY_1441"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1441"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="74" mass="8166" checksum="69C1FB257B302164" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITPKFIHTTGPGYSVVLLNKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GK7</accession>
    <name>Q32GK7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Murein peptide amidase A</fullName>
            <ecNumber evidence="1">3.4.17.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-D-Glu-Dap amidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Zinc metallocarboxypeptidase MpaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycjI</name>
        <name evidence="1" type="synonym">mpaA</name>
        <name evidence="3" type="ordered locus">SDY_1404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:28398"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:61395"/>
            <dbReference type="ChEBI" id="CHEBI:61401"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall degradation; peptidoglycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403039.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GK7"/>
    <dbReference type="STRING" id="300267.SDY_1404"/>
    <dbReference type="MEROPS" id="M14.034"/>
    <dbReference type="EnsemblBacteria" id="ABB61548">
        <property type="protein sequence ID" value="ABB61548"/>
        <property type="gene ID" value="SDY_1404"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1404"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1665"/>
    <dbReference type="HOGENOM" id="CLU_102905_0_0_6"/>
    <dbReference type="OMA" id="ACIEDPH"/>
    <dbReference type="UniPathway" id="UPA00549"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061473">
        <property type="term" value="F:murein tripeptide carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02211">
        <property type="entry name" value="MpaA_carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043691">
        <property type="entry name" value="MpaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="66"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="262" mass="28846" checksum="BF548CB4E726061E" modified="2005-12-06" version="1">MIIRKICTTLPVILPEPETIMTVTRPRAERGAFPPGTEHYGRSLLGAPLIWFPAPTASHESGLILAGTHGDENSSIVTLSCALRTLTPSLRRHHVVLCVNPDGCQLGLRANANGVDLNRNFPAANWKEGETVYRWNSAAEERDVVLLTGDKPGSEPETQALCQLIHRIQPAWVVSFHDPLACIEDPRHSELGEWLAQAFELPLVTSVGYETPGSFGSWCADLNLHCITAEFPPISSDEASEKYLFAMANLLRWHPKDAIRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GM6</accession>
    <name>Q32GM6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative host-nuclease inhibitor protein Gam</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gam</name>
        <name evidence="1" type="ordered locus">SDY_1384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000995032.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403020.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GM6"/>
    <dbReference type="STRING" id="300267.SDY_1384"/>
    <dbReference type="EnsemblBacteria" id="ABB61529">
        <property type="protein sequence ID" value="ABB61529"/>
        <property type="gene ID" value="SDY_1384"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1384"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1644"/>
    <dbReference type="HOGENOM" id="CLU_153760_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060703">
        <property type="term" value="F:deoxyribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009274">
        <property type="entry name" value="Gam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042034">
        <property type="entry name" value="Gam_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06064">
        <property type="entry name" value="Gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="98" mass="11536" checksum="A5A09821BD8887FC" modified="2005-12-06" version="1">MNAWLIPDRIEEQSWARHYQQIAREETEAELADDLEKGLPQHLFESLCIDNLQRHGASKKAISRAFDDDVDFQERMAEHIRYMAETIARHQINIDSEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H41</accession>
    <name>YCGL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YcgL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycgL</name>
        <name type="ordered locus">SDY_1211</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402855.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H41"/>
    <dbReference type="SMR" id="Q32H41"/>
    <dbReference type="STRING" id="300267.SDY_1211"/>
    <dbReference type="EnsemblBacteria" id="ABB61364">
        <property type="protein sequence ID" value="ABB61364"/>
        <property type="gene ID" value="SDY_1211"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1211"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1437"/>
    <dbReference type="HOGENOM" id="CLU_155118_1_0_6"/>
    <dbReference type="OMA" id="MICAVYK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.510.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01866">
        <property type="entry name" value="UPF0745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038068">
        <property type="entry name" value="YcgL-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027354">
        <property type="entry name" value="YcgL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38109">
        <property type="entry name" value="PTHR38109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05166">
        <property type="entry name" value="YcgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160191">
        <property type="entry name" value="SSF160191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51648">
        <property type="entry name" value="YCGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000375384" description="Protein YcgL">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="YcgL" evidence="1">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01866"/>
        </source>
    </evidence>
    <sequence length="108" mass="12421" checksum="A49CCA3DB6E6759E" modified="2005-12-06" version="1">MPKLGILKSKSMFCVIYRSSKRDQTYLYVEKKDDFSRVPEELMKGFGQPQLAMILPLDGRKKLVNADIEKVKQALTEQGYYLQLPPSPEDLLKQHLSVMGQKTDDTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H50</accession>
    <name>Q32H50_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402846.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H50"/>
    <dbReference type="STRING" id="300267.SDY_1202"/>
    <dbReference type="EnsemblBacteria" id="ABB61355">
        <property type="protein sequence ID" value="ABB61355"/>
        <property type="gene ID" value="SDY_1202"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1202"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1424"/>
    <dbReference type="HOGENOM" id="CLU_004643_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030930">
        <property type="entry name" value="AIDA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16168">
        <property type="entry name" value="AIDA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04415">
        <property type="entry name" value="O_hepto_targRPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="339" mass="35700" checksum="A7192DE48320D500" modified="2005-12-06" version="1">MNTIHLRCLFRRNPLVWCLRADVAAELRSLRRYSVFIFQRMKFMNRTSRYYFHRSVLSLLISAMIYAPPGMTAFTSNVIGVVNDETVDGSQRVDERGTTNNAHIINHGNQEVYGGVSNGSLIDTGGHQEVSGHGSYQGQANNTVINGGSQTISEGGISTGTIINDKGTMSVLTNAKADATRIDNGGVMDVAGNATNTIINGGTQNIYNHGIATGTNINSGTKNIKSGGKADTTNISSGSKQAVEKGGTATGSNIRAGGTLIVHTGGIAHGVYLDMGSALVANTGAGTDIDGYQRSSHFTITGGRAEHVVLENTGELTVVAQTSAVDTVMLPISRTCVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H61</accession>
    <name>Q32H61_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Flagellar transcriptional regulator FlhC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">flhC</name>
        <name evidence="6" type="ordered locus">SDY_1190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the FlhC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001291610.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402835.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H61"/>
    <dbReference type="STRING" id="300267.SDY_1190"/>
    <dbReference type="EnsemblBacteria" id="ABB61344">
        <property type="protein sequence ID" value="ABB61344"/>
        <property type="gene ID" value="SDY_1190"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1190"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1408"/>
    <dbReference type="HOGENOM" id="CLU_122824_1_0_6"/>
    <dbReference type="OMA" id="MLQLSAC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01891">
        <property type="entry name" value="FhlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007944">
        <property type="entry name" value="FlhC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05280">
        <property type="entry name" value="FlhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003159">
        <property type="entry name" value="FlhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4 5" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="181" mass="20207" checksum="CB3C0C2F83255E9D" modified="2005-12-06" version="1">MSEKSIVQEARDIQLAMELITLGARLQMLESETQLSRGSPPPKGMLPFSTDWFMTWEQNVHASMFCNAWQFLLKTGLCNGVDAVIKAYRLYLEQCPQAEEGPLLALIRAWTLVRFVESGLLQLSSCNCCGGNFITHAHQPVGSFACSLCQPPSRAVKRRKLSQNPADIIPQLLDEQRVQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HP7</accession>
    <name>Q32HP7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HP7"/>
    <dbReference type="EnsemblBacteria" id="ABB61158">
        <property type="protein sequence ID" value="ABB61158"/>
        <property type="gene ID" value="SDY_0991"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0991"/>
    <dbReference type="HOGENOM" id="CLU_1101562_0_0_6"/>
    <dbReference type="OMA" id="NGPHEYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="297" mass="34198" checksum="9A6FA2A6ECA3D541" modified="2005-12-06" version="1">MEPLISGPYGQYSRMKIKTGCMKHARYSPAQQYGREETHFTNNGMREFGNMSPLAWRNDVELQQSCNTSNIPPSTANDDINNTRQTIEDEPQQYVKLTVDDMRKWAAMDQQARNALQGVPRWCTRNHFNIKNARNYLTDHGLNYAGQVKVNRPHEYAKFTLEHIRQWAALNKHVRKPVGYLEKWCKERNPAPTTARNYLKNDGLTALGELKLTGPQKWVTFTFGDIVQWANMTQEERNSAGGAEKWSKKRGFQWSTARSYLKSSGVTKQGAKKLTWLKNSGNMSNPFYLAQPTSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I15</accession>
    <name>Q32I15_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9 12">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="3 9 12">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yojL</name>
        <name evidence="13" type="ordered locus">SDY_0862</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 12">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="3 9 12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000406061.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402531.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I15"/>
    <dbReference type="STRING" id="300267.SDY_0862"/>
    <dbReference type="EnsemblBacteria" id="ABB61040">
        <property type="protein sequence ID" value="ABB61040"/>
        <property type="gene ID" value="SDY_0862"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0862"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.996"/>
    <dbReference type="HOGENOM" id="CLU_044403_0_0_6"/>
    <dbReference type="OMA" id="MGTFWRV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB61040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="351" mass="38563" checksum="41437D26A0F843D2" modified="2005-12-06" version="1">MEISFTRVALLAAALFFVGCDQKPQPAKTHATEVTVLEGKTMGTFWRASIPGIDAKRSAELKEKIQTQLDADDQLLSTYKKDSALMRFNDSQSLSPWPVSEAMADIVTTSLRIGAKTDGAMDITVGPLVNLWGFGPEQQPVQIPSQEQIDAMKAKTGLQHLTVINQSHQQYLQKDLPDLYVDLSTVGEGYAADHLARLMEQEGISRYLVSVGGALNSRGMNGEGLPWRIAIQKPTDKENAVQAVVDINGHGISTSGSYRNYYELDGKRLSHVIDPQTGRPIEHNLVSVTVIAPTALEADAWDTGLMVLGPEKAKEVVRREGLAVYMITKEGDSFKTWMSPQFKSFLVSEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I17</accession>
    <name>Q32I17_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I17"/>
    <dbReference type="EnsemblBacteria" id="ABB61038">
        <property type="protein sequence ID" value="ABB61038"/>
        <property type="gene ID" value="SDY_0860"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0860"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8361" checksum="F659A3CD0D4E07FD" modified="2005-12-06" version="1">MAVTAAKSVMAFRVMTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITLVASEGFVLTFSAVKYLRISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I42</accession>
    <name>Q32I42_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybhB</name>
        <name evidence="1" type="ordered locus">SDY_0833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000767384.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402504.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I42"/>
    <dbReference type="STRING" id="300267.SDY_0833"/>
    <dbReference type="EnsemblBacteria" id="ABB61015">
        <property type="protein sequence ID" value="ABB61015"/>
        <property type="gene ID" value="SDY_0833"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0833"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.959"/>
    <dbReference type="HOGENOM" id="CLU_083918_2_0_6"/>
    <dbReference type="OMA" id="LAWDEVP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="158" mass="17159" checksum="D5764A36CE838645" modified="2005-12-06" version="1">MKLISNDLRDGDKLPHRHVFNGMGYDGDNISPHLAWDDVPAGTKSFVVTCYDPDAPTGSGWWHWVVVNLPADTRELPQGFGSDLVAMPDGVLQTRTDFGKTGYDGAAPPKGETHRYIFTVHALDVERIDVDEGASGAMVGFNVHFHSLASASITAMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IA1</accession>
    <name>Q32IA1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage tail fiber protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402445.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IA1"/>
    <dbReference type="EnsemblBacteria" id="ABB60956">
        <property type="protein sequence ID" value="ABB60956"/>
        <property type="gene ID" value="SDY_0772"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0772"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.888"/>
    <dbReference type="HOGENOM" id="CLU_014979_3_0_6"/>
    <dbReference type="OMA" id="EYDFPVL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013609">
        <property type="entry name" value="Stf-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08400">
        <property type="entry name" value="phage_tail_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="phage_tail_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="350" mass="37773" checksum="27EB6E3709D457EB" modified="2005-12-06" version="1">MPQLKGVIKTPTGEPLGGATITLTSLHNRAGILKGVFSHVTTQSGEYDFPVLPGVYSVRLTQSAQRLSEIGVIRVYEDSADGSLNDFLGATDIDLRPESLKKFEELAQQAQQSAGAAAGNAQQTAQDVAAAATARDDAQRFAEKARQDATVTAENRKATAEDVKSTGKNAVLSGQRAQAAAGYARAAEQAKNDIYAALTGTLKTANHLSEIAAAGEKAQQKSRDNLGLKSAATMEAQSDIYDRTKGRLAIPGAFGFGRAFLYEDVIRFDTKSDFLARVRNALPGEYSVAGPYGIIIPDIRFEGVLSIRWTDARPETTEPRYRAKSLTFYGINGPIYHTRYCYWPISRLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IA3</accession>
    <name>Q32IA3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_0770</name>
        <name evidence="5" type="ordered locus">SDY_1326</name>
        <name evidence="6" type="ordered locus">SDY_1352</name>
        <name evidence="7" type="ordered locus">SDY_1444</name>
        <name evidence="8" type="ordered locus">SDY_1452</name>
        <name evidence="9" type="ordered locus">SDY_1481</name>
        <name evidence="10" type="ordered locus">SDY_1678</name>
        <name evidence="11" type="ordered locus">SDY_1789</name>
        <name evidence="12" type="ordered locus">SDY_1901</name>
        <name evidence="13" type="ordered locus">SDY_2008</name>
        <name evidence="14" type="ordered locus">SDY_2184</name>
        <name evidence="15" type="ordered locus">SDY_2291</name>
        <name evidence="16" type="ordered locus">SDY_2411</name>
        <name evidence="17" type="ordered locus">SDY_2755</name>
        <name evidence="18" type="ordered locus">SDY_2770</name>
        <name evidence="19" type="ordered locus">SDY_2819</name>
        <name evidence="20" type="ordered locus">SDY_2843</name>
        <name evidence="21" type="ordered locus">SDY_2990</name>
        <name evidence="22" type="ordered locus">SDY_4195</name>
    </gene>
    <organism evidence="4 23">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 23" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 23">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62484.1"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Homeobox-like_sf"/>
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        <property type="entry name" value="Transposase_8"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB61902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB62103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB62270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB62368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB62484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB62798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB62813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABB62862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ABB62882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ABB63013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ABB64100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11180" checksum="2973A770DE5B3601" modified="2005-12-06" version="1">MSRKTQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGTLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKATAYFAQESLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IA6</accession>
    <name>Q32IA6_SHIDS</name>
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        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IA6"/>
    <dbReference type="EnsemblBacteria" id="ABB60951">
        <property type="protein sequence ID" value="ABB60951"/>
        <property type="gene ID" value="SDY_0767"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0767"/>
    <dbReference type="HOGENOM" id="CLU_097144_0_0_6"/>
    <dbReference type="OMA" id="WGLSFST"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="181" mass="20141" checksum="0BE881FB843ACCB0" modified="2005-12-06" version="1">MDKLKGKSLSLPEVTKESIPERLRELIGKRSVRAAAKDWGLSFSTLNNYLTRGTEPSLSVVRQIAAIEGVTIEWICGSHYDSHENQSISTNTHNENTKLIMNIINALDAKDIERLSKTLALNGAKYLTQILEPENQGLLRLEGRKRVAALLLDDLPDECIREILEEIESSKLSSSVKSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IH5</accession>
    <name>Q32IH5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000784362.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402371.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IH5"/>
    <dbReference type="STRING" id="300267.SDY_0697"/>
    <dbReference type="EnsemblBacteria" id="ABB60882">
        <property type="protein sequence ID" value="ABB60882"/>
        <property type="gene ID" value="SDY_0697"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0697"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.808"/>
    <dbReference type="HOGENOM" id="CLU_161896_0_0_6"/>
    <dbReference type="OMA" id="EVHKNTM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020363">
        <property type="entry name" value="Uncharacterised_YbgS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13985">
        <property type="entry name" value="YbgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221020" evidence="2">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="126" mass="12911" checksum="48EEAEAF52F0E878" modified="2005-12-06" version="1">MKMTKLATLFLTATLSLASGAALAADSGAQTNNGQTNAAADAGQVAPDARENVAPNNVDNNGVNTGSGGTMLHPDGSSMNNDGMTKNEEHKNTMCKDGRCPDINKKVQTGDGINNDVDTKTDGTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IT7</accession>
    <name>Q32IT7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402259.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IT7"/>
    <dbReference type="STRING" id="300267.SDY_0566"/>
    <dbReference type="EnsemblBacteria" id="ABB60770">
        <property type="protein sequence ID" value="ABB60770"/>
        <property type="gene ID" value="SDY_0566"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0566"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.669"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_1_6"/>
    <dbReference type="OMA" id="MKIGRAN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="106"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32309" checksum="2DD9FAE15E732517" modified="2005-12-06" version="1">MVTLCHVFGVHRSSYRYWKNRPEKPDGRRAVLRSQVLELHGISHGSAGARSIATMATRRGYQMGRWLAGRLMKELGLVSCQQPTHRYKRGGHEHVAIPNYLERQFAVTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKPGGVMFHSDQGSHYTSRQFRQLLWRYQIRQSMSRRGNCRDNSPMERFFRSLKNEWMPVVGYVSFSEAAHAITDYIVGYYSALRPHEYNGGLPPNESENRYWKNSNSVASFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J40</accession>
    <name>Q32J40_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haemolysin expression modulating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hha</name>
        <name evidence="3" type="ordered locus">SDY_0459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Hha/YmoA/Cnu family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001291435.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402156.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J40"/>
    <dbReference type="SMR" id="Q32J40"/>
    <dbReference type="STRING" id="300267.SDY_0459"/>
    <dbReference type="EnsemblBacteria" id="ABB60667">
        <property type="protein sequence ID" value="ABB60667"/>
        <property type="gene ID" value="SDY_0459"/>
    </dbReference>
    <dbReference type="GeneID" id="66671238"/>
    <dbReference type="KEGG" id="sdy:SDY_0459"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.542"/>
    <dbReference type="HOGENOM" id="CLU_190629_0_0_6"/>
    <dbReference type="OMA" id="RRCQSID"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007985">
        <property type="entry name" value="Hemolysn_expr_modulating_HHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036666">
        <property type="entry name" value="HHA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05321">
        <property type="entry name" value="HHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68989">
        <property type="entry name" value="SSF68989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8628" checksum="A77211B87CF0134A" modified="2005-12-06" version="1">MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JH1</accession>
    <name>Q32JH1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">thiL</name>
        <name evidence="5" type="ordered locus">SDY_0317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000742105.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402025.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JH1"/>
    <dbReference type="STRING" id="300267.SDY_0317"/>
    <dbReference type="EnsemblBacteria" id="ABB60536">
        <property type="protein sequence ID" value="ABB60536"/>
        <property type="gene ID" value="SDY_0317"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0317"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.366"/>
    <dbReference type="HOGENOM" id="CLU_046964_3_0_6"/>
    <dbReference type="OMA" id="HFRRDWS"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="150"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="121"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="325" mass="35116" checksum="43FFD658B8CFEA0C" modified="2005-12-06" version="1">MACGEFSLIARYFDRVRSSRLDVELGIGDDCALLNIPEKQTLAISTDTLVAGNHFLPDIDPADLAYKALAVNLSDLAAMGADPAWLTLALTLPDVDEAWLESFSDSLFDLLNYYDMQLIGGDTTRGPLSMTLGIHGFVPMGRALTRSGAKPGDWIYVTGTPGDSAAGLAILQNRLQVADAKDADYLIKRHLRPSPRILQGQALRDLANSAIDLSDGLISDLGHIVKASDCGARIDLALLPFSDALSHHVEPEQALRWALSGGEDYELCFTVPELNRGALDVALGHLGVPFTCIGQMTADIEGFCFIRDSEPVTLDWKGYDHFATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JH5</accession>
    <name>Q32JH5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402021.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JH5"/>
    <dbReference type="EnsemblBacteria" id="ABB60532">
        <property type="protein sequence ID" value="ABB60532"/>
        <property type="gene ID" value="SDY_0313"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0313"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.360"/>
    <dbReference type="HOGENOM" id="CLU_1894775_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="134" mass="15802" checksum="F1C7821BFE11269B" modified="2005-12-06" version="1">MEASPTILPDIVRMKGTKLYRTDLFNPILKTEAESTEENDISPLAKIILDYIESDKNPESLNFEEKSTVIKIKQDIYNFIFYNQHLKEIFNRAMNLQGKISRKKYNEFFKYIQAEAKQYFKDQYKLTKNGDASN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JI1</accession>
    <name>THII_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA sulfurtransferase</fullName>
            <ecNumber evidence="1">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiI</name>
        <name type="ordered locus">SDY_0307</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiI family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000668706.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402015.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JI1"/>
    <dbReference type="SMR" id="Q32JI1"/>
    <dbReference type="STRING" id="300267.SDY_0307"/>
    <dbReference type="EnsemblBacteria" id="ABB60526">
        <property type="protein sequence ID" value="ABB60526"/>
        <property type="gene ID" value="SDY_0307"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0307"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.352"/>
    <dbReference type="HOGENOM" id="CLU_037952_4_1_6"/>
    <dbReference type="OMA" id="SMPEFCG"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026340">
        <property type="entry name" value="Thiazole_biosynth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04271">
        <property type="entry name" value="ThiI_C_thiazole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000074278" description="tRNA sulfurtransferase">
        <location>
            <begin position="1"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="THUMP" evidence="1">
        <location>
            <begin position="61"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="404"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="344"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <sequence length="482" mass="54962" checksum="00FAB35849600966" modified="2005-12-06" version="1">MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLTIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALVQYRDQLEGKTFCVRVKRSGKHDFSSIDVERYVGGGLNQHIESARVKLTNPDVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKIDDGQMGVILKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAVKSKIEAEEEKFDFSILDKVVEEANNVDIREIAQQTEQEVVEVETVNDCGPNDVILDIRSVDEQEDKPLKVEGIDVVSLPFYKLSTKFGDLDQNRTWLLWCERGVMSRLQALYLREQGFNNVKVYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JR1</accession>
    <name>Q32JR1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Outer membrane lipoprotein RcsF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">rcsF</name>
        <name evidence="4" type="ordered locus">SDY_0215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RcsF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001202329.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401935.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JR1"/>
    <dbReference type="SMR" id="Q32JR1"/>
    <dbReference type="STRING" id="300267.SDY_0215"/>
    <dbReference type="EnsemblBacteria" id="ABB60446">
        <property type="protein sequence ID" value="ABB60446"/>
        <property type="gene ID" value="SDY_0215"/>
    </dbReference>
    <dbReference type="GeneID" id="67416273"/>
    <dbReference type="KEGG" id="sdy:SDY_0215"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.249"/>
    <dbReference type="HOGENOM" id="CLU_142248_1_0_6"/>
    <dbReference type="OMA" id="FRDMGEV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036406">
        <property type="term" value="C:anchored component of periplasmic side of cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00976">
        <property type="entry name" value="RcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030852">
        <property type="entry name" value="RcsF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16358">
        <property type="entry name" value="RcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008969458" description="Outer membrane lipoprotein RcsF" evidence="3">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="134" mass="14163" checksum="824F82151C07BB41" modified="2005-12-06" version="1">MRALPICLVALMLSGCSMLSRSPVEPVQSTAPQPKAEPAKPKAPRATPVRIYTNAEELVGKPFRDLGEVSGDSCQASNQDSPPSIPTARKRMQINASKMKANAVLLHSCEVTSGTPGCYRQAVCIGSALNITAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JR3</accession>
    <name>SYP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="1">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proS</name>
        <name type="ordered locus">SDY_0213</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001260719.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401933.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JR3"/>
    <dbReference type="SMR" id="Q32JR3"/>
    <dbReference type="STRING" id="300267.SDY_0213"/>
    <dbReference type="EnsemblBacteria" id="ABB60444">
        <property type="protein sequence ID" value="ABB60444"/>
        <property type="gene ID" value="SDY_0213"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0213"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.247"/>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_6"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001535">
        <property type="entry name" value="ProRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000248764" description="Proline--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <sequence length="572" mass="63634" checksum="8DE65ACC9986A959" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JS4</accession>
    <name>ACCA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="1">ACCase subunit alpha</shortName>
            <shortName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="1">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">accA</name>
        <name type="ordered locus">SDY_0201</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000055741.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401922.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JS4"/>
    <dbReference type="SMR" id="Q32JS4"/>
    <dbReference type="STRING" id="300267.SDY_0201"/>
    <dbReference type="EnsemblBacteria" id="ABB60433">
        <property type="protein sequence ID" value="ABB60433"/>
        <property type="gene ID" value="SDY_0201"/>
    </dbReference>
    <dbReference type="GeneID" id="66671527"/>
    <dbReference type="KEGG" id="sdy:SDY_0201"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.232"/>
    <dbReference type="HOGENOM" id="CLU_015486_0_2_6"/>
    <dbReference type="OMA" id="TPWQRVQ"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000223823" description="Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01137"/>
        </source>
    </evidence>
    <sequence length="319" mass="35242" checksum="A810DE891CEA2B4F" modified="2005-12-06" version="1">MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQIAQLARHPQRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLDGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMQMAERFKMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLGVPVVCTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLADLADLDVLSTEDLKNRRYQRLMSYGYA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JS8</accession>
    <name>LPXA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase</fullName>
            <shortName evidence="1">UDP-N-acetylglucosamine acyltransferase</shortName>
            <ecNumber evidence="1">2.3.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxA</name>
        <name type="ordered locus">SDY_0197</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:67812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="2.3.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family. LpxA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000565966.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401918.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JS8"/>
    <dbReference type="SMR" id="Q32JS8"/>
    <dbReference type="STRING" id="300267.SDY_0197"/>
    <dbReference type="EnsemblBacteria" id="ABB60429">
        <property type="protein sequence ID" value="ABB60429"/>
        <property type="gene ID" value="SDY_0197"/>
    </dbReference>
    <dbReference type="GeneID" id="67416257"/>
    <dbReference type="KEGG" id="sdy:SDY_0197"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.228"/>
    <dbReference type="HOGENOM" id="CLU_061249_0_0_6"/>
    <dbReference type="OMA" id="ECVTINR"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00387">
        <property type="entry name" value="LpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000302602" description="Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00387"/>
        </source>
    </evidence>
    <sequence length="262" mass="28080" checksum="B42B076F0045B44C" modified="2005-12-06" version="1">MIDKSAFVHPTAIVEEGASIGANAHIGPFCIVGPHVEIGEGTVLKSHVVVNGHTKIGRDNEIYQFASIGEVNQDLKYAGEPTRVEIGDRNRIRESVTIHRGTVQGGGLTKVGSDNLLMINAHIAHDCTVGNRCILANNATLAGHVSVDDFAIIGGMTAVHQFCIIGAHVMVGGCSGVAQDVPPYVIAQGNHATPFGVNIEGLKRRGFSREAITAIRNAYKLIYRSGKTLDEVKPEIAELAETYPEVKAFTDFFARSTRGLIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JZ9</accession>
    <name>FTSQ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein FtsQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ftsQ</name>
        <name type="ordered locus">SDY_0123</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of a complex composed of FtsB, FtsL and FtsQ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes to the division septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsQ/DivIB family. FtsQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000075735.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401847.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JZ9"/>
    <dbReference type="SMR" id="Q32JZ9"/>
    <dbReference type="STRING" id="300267.SDY_0123"/>
    <dbReference type="EnsemblBacteria" id="ABB60358">
        <property type="protein sequence ID" value="ABB60358"/>
        <property type="gene ID" value="SDY_0123"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0123"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.142"/>
    <dbReference type="HOGENOM" id="CLU_064041_2_1_6"/>
    <dbReference type="OMA" id="MARIQRF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00911">
        <property type="entry name" value="FtsQ_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005548">
        <property type="entry name" value="Cell_div_FtsQ/DivIB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026579">
        <property type="entry name" value="FtsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045335">
        <property type="entry name" value="FtsQ_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35851">
        <property type="entry name" value="PTHR35851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03799">
        <property type="entry name" value="FtsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000414695" description="Cell division protein FtsQ">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="49"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="2">
        <location>
            <begin position="55"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="276" mass="31378" checksum="CACDA34D56812985" modified="2005-12-06" version="1">MSQAALNTRNSEEEVSSRRNNGTRLAGILFLLTVLTTVLVSGWGVLGWMEDAQRLPLSKLVLTGERHYTRNDDIRQSILALGEPGTFMTQDVNIIQTQIEQRLPWIKQVSVRKQWPDELKIHLVEYVPIARWNDQHMVDAEGNTFSVPPDRTSKQVLPMLYGPEGSANEVLQGYREMGQMLAKDRFTLKEAAMTARRSWQLTLNNDIKLNLGRGDTMKRLARFVELYPVLQQQAQTDGKRISYVDLRYDSGAAVGWAPLPPEESTQQQNQAQAEQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K62</accession>
    <name>CAIE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carnitine operon protein CaiE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">caiE</name>
        <name type="ordered locus">SDY_0057</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Overproduction of CaiE stimulates the activity of CaiB and CaiD.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine metabolism; carnitine metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60295" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60295.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000122900.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401784.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K62"/>
    <dbReference type="SMR" id="Q32K62"/>
    <dbReference type="STRING" id="300267.SDY_0057"/>
    <dbReference type="EnsemblBacteria" id="ABB60295">
        <property type="protein sequence ID" value="ABB60295"/>
        <property type="gene ID" value="SDY_0057"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0057"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.63"/>
    <dbReference type="HOGENOM" id="CLU_064827_4_2_6"/>
    <dbReference type="UniPathway" id="UPA00117"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01525">
        <property type="entry name" value="CaiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023446">
        <property type="entry name" value="CaiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000292726" description="Carnitine operon protein CaiE">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="196" mass="21204" checksum="732F0FA566651B1B" modified="2007-06-26" version="2">MSYYAFEGLIPVVHPTAFVHPSAVLIGYVIVGAGVYIGPLASLRGDYGRLIVQAGANIQDGCIMHGYCDTDTIVGENGHIGHGAILHGCVIGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFHGEKRQLLMGTPARAVRSVSDDELHWKRLNTKEYQDLVGRCHASLHETQPLRQMEENRPRLQGTTDVTPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K84</accession>
    <name>Q32K84_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 6">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yadF</name>
        <name evidence="7" type="ordered locus">SDY_0035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000651601.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401762.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K84"/>
    <dbReference type="STRING" id="300267.SDY_0035"/>
    <dbReference type="EnsemblBacteria" id="ABB60273">
        <property type="protein sequence ID" value="ABB60273"/>
        <property type="gene ID" value="SDY_0035"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0035"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.39"/>
    <dbReference type="HOGENOM" id="CLU_053879_3_0_6"/>
    <dbReference type="OMA" id="PANEIIG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="220" mass="25123" checksum="48A9086BF3F28452" modified="2005-12-06" version="1">MKDIDTLISNNALWSKMLVEEDPGFFEKLAQAQKPRFLWIGCSDSRVPAERLTGLEPGELFVHRNVANLVIHTDLNCLSVVQYAVDVLEVEHIIICGHYGCGGVQAAVENPELGLINNWLLHIRDIWFKHSSLLGEMPQERRLDTLCELNVMEQVYNLGHSTIMQSAWKRGQKVTIHGWAYGIHDGLLRDLDVTATNRETLEQRYRHGISNLKLKYANHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-09-11" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A7FAA8</accession>
    <name>A7FAA8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Spa9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">spa9</name>
        <name evidence="9" type="ORF">SDY_P191a</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Sd197</strain>
            <plasmid evidence="10">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABS59871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001280546.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001449235.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7FAA8"/>
    <dbReference type="EnsemblBacteria" id="ABS59871">
        <property type="protein sequence ID" value="ABS59871"/>
        <property type="gene ID" value="SDY_P191a"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P191a"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5743"/>
    <dbReference type="HOGENOM" id="CLU_164516_1_2_6"/>
    <dbReference type="OMA" id="IKLLAVF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006306">
        <property type="entry name" value="T3SS_HrpO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01403">
        <property type="entry name" value="fliQ_rel_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABS59871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9443" checksum="552A3ABCB9C893B3" modified="2007-09-11" version="1">MSDIVYMGNKALYLILIFSLWPVGIATVIGLTIGLLQTVTQLQEQTLPFGIKLIGVSISLLLLSGWYGEVLLSFCHEIMFLIKSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q326P7</accession>
    <name>Q326P7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406199.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326P7"/>
    <dbReference type="EnsemblBacteria" id="ABB64711">
        <property type="protein sequence ID" value="ABB64711"/>
        <property type="gene ID" value="SDY_P198"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P198"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5750"/>
    <dbReference type="HOGENOM" id="CLU_101784_0_0_6"/>
    <dbReference type="OMA" id="MIEINAQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="258" mass="30462" checksum="1A75C7A845FF4198" modified="2005-12-06" version="1">MKIKRSTFISNIFYIISWFLMNDNSLLRNSSLFIAYMGCVGWVSAYSYGWGTSFYYGFPWWVVGAGLDDVARSLLYAIIVMGILFTGWGIGILFFLLIKKRSKIQDLSFFRLFFAITLLFFPVIFELLILKQYFILPLSLSCIISSLVISIIIRIYGRIFSVSCFSDIPFVREHRIKLIMAGFLVYFWLFSFLVGWYKPQLKKEYQMLCYNNSWYYVLARYDSRLVLSSSFKDDSNRFLIFNTEQSGFYEINDVYVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Q1</accession>
    <name>Q326Q1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spa-orf10</name>
        <name evidence="1" type="ordered locus">SDY_P194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406195.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Q1"/>
    <dbReference type="EnsemblBacteria" id="ABB64707">
        <property type="protein sequence ID" value="ABB64707"/>
        <property type="gene ID" value="SDY_P194"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P194"/>
    <dbReference type="HOGENOM" id="CLU_164045_2_0_6"/>
    <dbReference type="OMA" id="VIKLDIY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071468">
        <property type="term" value="P:cellular response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024753">
        <property type="entry name" value="AriR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10798">
        <property type="entry name" value="YmgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="77" mass="8687" checksum="488F7413E2C1E83F" modified="2005-12-06" version="1">MGVNFCNKIGIDQSEFEIESSIINSIANEVLNPISFLSNKDIINVLLRKISSECDLVRKDIYRCALELVVEKTPDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q326S0</accession>
    <name>Q326S0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MxiH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mxiH</name>
        <name evidence="3" type="ordered locus">SDY_P175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MxiH/PrgI/YscF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378999.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406176.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326S0"/>
    <dbReference type="EnsemblBacteria" id="ABB64688">
        <property type="protein sequence ID" value="ABB64688"/>
        <property type="gene ID" value="SDY_P175"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P175"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5732"/>
    <dbReference type="HOGENOM" id="CLU_171855_1_1_6"/>
    <dbReference type="OMA" id="PNKDWTL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021123">
        <property type="entry name" value="T3SS_needle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037203">
        <property type="entry name" value="T3SS_needle-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011841">
        <property type="entry name" value="T3SS_needle_YscF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09392">
        <property type="entry name" value="T3SS_needle_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140129">
        <property type="entry name" value="SSF140129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02105">
        <property type="entry name" value="III_needle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9224" checksum="1B24A17D8288EBB8" modified="2005-12-06" version="1">MSVTVPNKDWTLSSLSETFDDGTQTLQGELTLALEALATNPSNPQLLAEYQSKLSEYTLYRNAQSNTVKVIKDVDAAIIQNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q326V7</accession>
    <name>Q326V7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406139.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326V7"/>
    <dbReference type="EnsemblBacteria" id="ABB64651">
        <property type="protein sequence ID" value="ABB64651"/>
        <property type="gene ID" value="SDY_P138"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P138"/>
    <dbReference type="HOGENOM" id="CLU_203131_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="31" mass="3425" checksum="08841A9BA3DE0A7E" modified="2005-12-06" version="1">MKSVNQYRLTPGFGGFTPVSHVTTACRLPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q326W6</accession>
    <name>Q326W6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative iso-IS1 orf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406130.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326W6"/>
    <dbReference type="EnsemblBacteria" id="ABB64642">
        <property type="protein sequence ID" value="ABB64642"/>
        <property type="gene ID" value="SDY_P129"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P129"/>
    <dbReference type="HOGENOM" id="CLU_185339_0_0_6"/>
    <dbReference type="OMA" id="LIWPMNG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="70" mass="7649" checksum="9B725BA1EBACF2B0" modified="2005-12-06" version="1">MYDGVFEVLQWLLFLSAVPPVQLLTGWCVTAKALPDISAISALTAVKHGNCSSLTPLLNPVRTRKSLIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q327F2</accession>
    <name>Q327F2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISSfl1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406044.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327F2"/>
    <dbReference type="EnsemblBacteria" id="ABB64556">
        <property type="protein sequence ID" value="ABB64556"/>
        <property type="gene ID" value="SDY_P043"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P043"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5588"/>
    <dbReference type="HOGENOM" id="CLU_055261_9_2_6"/>
    <dbReference type="OMA" id="FIAFINF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13586">
        <property type="entry name" value="DDE_Tnp_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="129" mass="14913" checksum="8634E41B98A38EBE" modified="2005-12-06" version="1">MLSPGQAHESQFAQRLLDGIGVQRQNGSMKRRGHAVLADKAYSGRALRNELKNNGIKAVIPRKSNEKMASDGRAQLDRDAYRNRNVVERCFGRLKEYRRIATRYDKTARNYLAMVKLGCIRLFYQRLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q327T1</accession>
    <name>Q327T1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405915.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327T1"/>
    <dbReference type="STRING" id="300267.SDY_4557"/>
    <dbReference type="EnsemblBacteria" id="ABB64424">
        <property type="protein sequence ID" value="ABB64424"/>
        <property type="gene ID" value="SDY_4557"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4557"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5389"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="MIVCCEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14944" checksum="F0656065CF754B56" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKIIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q327T5</accession>
    <name>Q327T5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
            <ecNumber evidence="2">2.7.7.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yhjK</name>
        <name evidence="9" type="ordered locus">SDY_4549</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24898"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="2.7.7.65"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405911.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327T5"/>
    <dbReference type="STRING" id="300267.SDY_4549"/>
    <dbReference type="EnsemblBacteria" id="ABB64420">
        <property type="protein sequence ID" value="ABB64420"/>
        <property type="gene ID" value="SDY_4549"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4549"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5378"/>
    <dbReference type="HOGENOM" id="CLU_000445_70_46_6"/>
    <dbReference type="OMA" id="DREMGMQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50887"/>
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        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
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    <sequence length="651" mass="73135" checksum="910353BB352BC650" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="ABB64373">
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            <dbReference type="Pfam" id="PF00892"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="307" mass="33122" checksum="DBFAFDF3EBCCA1F3" modified="2005-12-06" version="1">MGSTRKGMLNVLIAAVLWGSSGVCAQYIMEQSHMSSQFLTMTRLIFAGLILLTLSFVHGDKIFSIINNHKDAISLLIFSVVGALTVQLTFLLTIEKSNAATATVLQFLSPTIIVAWFSLVRKSRPGILVFCAILTSLVGTFLLVTHGNPTSLSISPAALFWGIASAFAAAFYTTYPSTLIARYGTLPVVGWSMLIGGLILLPFYARQGTNFVVNGSLILAFFYLVVIGTSLTFSLYLKGAQLIGGPKASILSCAEPLSSALLSLLLLGITFTLPDWLGTLLILSSVILISMDSRRRARKINRPARHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q328C6</accession>
    <name>Q328C6_SHIDS</name>
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        </submittedName>
    </protein>
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    </gene>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328C6"/>
    <dbReference type="STRING" id="300267.SDY_4447"/>
    <dbReference type="EnsemblBacteria" id="ABB64329">
        <property type="protein sequence ID" value="ABB64329"/>
        <property type="gene ID" value="SDY_4447"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4447"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5246"/>
    <dbReference type="HOGENOM" id="CLU_007946_18_0_6"/>
    <dbReference type="OMA" id="WWVGSRG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="66"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="415" mass="44596" checksum="768A43509123AA81" modified="2005-12-06" version="1">MSGLKQELGLAQGIGLLSTSLLGTGVFAVPALAALVAGNNSLWAWPVLIILVFPIAIVFAILGRHYPSAGGVAHFVGMAFGSRLERVTGWLFLSVIPVGLPAALQIAAGFGQAMFGWHSWQLLLAELGTLALVWYIGTRGASSSANLQTVIAGLIVALIVAIWWAGDIKPASIPFPAPRNIELTGLFAALSVMFWCFVGLEAFAHLASEFKNPERDFPRALMIGLLLAGLVYWGCTVVVLHFDAYGEQMAAAASLPKIVVQLFGVGALWIACVIGYLACFASLNIYIQSFARLVWSQAQHNPDHYLARLSSRHIPNNALNAVLGCCVVSTLVIHALEINLDALIIYANGIFIMIYLLCMLAGCKLLQGRYRLLAVVGGLLCVLLLAMIGWKSLYALIMLAGLWLFLPKRVMPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q328D6</accession>
    <name>Q328D6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328D6"/>
    <dbReference type="EnsemblBacteria" id="ABB64319">
        <property type="protein sequence ID" value="ABB64319"/>
        <property type="gene ID" value="SDY_4436"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4436"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8081" checksum="8294068DEC6A5500" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITLLMTYVVLRYSASQRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q328G2</accession>
    <name>Q328G2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3998</name>
        <name evidence="4" type="ordered locus">SDY_4406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405409.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405784.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_3998"/>
    <dbReference type="EnsemblBacteria" id="ABB63918">
        <property type="protein sequence ID" value="ABB63918"/>
        <property type="gene ID" value="SDY_3998"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64293">
        <property type="protein sequence ID" value="ABB64293"/>
        <property type="gene ID" value="SDY_4406"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3998"/>
    <dbReference type="KEGG" id="sdy:SDY_4406"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4707"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15406" checksum="947934E736B674CB" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCWELLALLTPFNIGMIISDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q328G7</accession>
    <name>Q328G7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328G7"/>
    <dbReference type="EnsemblBacteria" id="ABB64288">
        <property type="protein sequence ID" value="ABB64288"/>
        <property type="gene ID" value="SDY_4401"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4401"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7584" checksum="95B15A8D31E6C023" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITVYGNRRTGWWYF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q328K2</accession>
    <name>ULAC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ascorbate-specific PTS system EIIA component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ascorbate-specific phosphotransferase enzyme IIA component</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ulaC</name>
        <name type="ordered locus">SDY_4364</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">Induced by L-ascorbate. Repressed by UlaR.</text>
    </comment>
    <comment type="domain">
        <text evidence="2">The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000776544.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405744.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328K2"/>
    <dbReference type="SMR" id="Q328K2"/>
    <dbReference type="STRING" id="300267.SDY_4364"/>
    <dbReference type="EnsemblBacteria" id="ABB64253">
        <property type="protein sequence ID" value="ABB64253"/>
        <property type="gene ID" value="SDY_4364"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4364"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5152"/>
    <dbReference type="HOGENOM" id="CLU_072531_2_0_6"/>
    <dbReference type="OMA" id="MGPYIIL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0598">Phosphotransferase system</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000230319" description="Ascorbate-specific PTS system EIIA component">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P69820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="154" mass="17224" checksum="1EFC3D51D0FDCF23" modified="2005-12-06" version="1">MKLRDSLAVNKSIRLQAEAETWQDAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPYFVIAPGLTMPHGRPEEGVKKTGFSLVTLKKPLEFNHDDNDPVDILITMAAVDANTHQEVGIMQIVNLFEDEENFDRLRACRTEQEVLDLIDRTNAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q328X4</accession>
    <name>Q328X4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS2 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405622.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328X4"/>
    <dbReference type="EnsemblBacteria" id="ABB64131">
        <property type="protein sequence ID" value="ABB64131"/>
        <property type="gene ID" value="SDY_4229"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4229"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4980"/>
    <dbReference type="HOGENOM" id="CLU_027402_25_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="121" mass="13461" checksum="5943009379C3067A" modified="2005-12-06" version="1">MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKHIKELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q329E0</accession>
    <name>Q329E0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IlvB operon leader peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ivbL</name>
        <name evidence="1" type="ordered locus">SDY_4156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001312198.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405556.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329E0"/>
    <dbReference type="EnsemblBacteria" id="ABB64065">
        <property type="protein sequence ID" value="ABB64065"/>
        <property type="gene ID" value="SDY_4156"/>
    </dbReference>
    <dbReference type="GeneID" id="58461848"/>
    <dbReference type="KEGG" id="sdy:SDY_4156"/>
    <dbReference type="HOGENOM" id="CLU_218700_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012566">
        <property type="entry name" value="IlvB_leader"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08049">
        <property type="entry name" value="IlvB_leader"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="32" mass="3240" checksum="7CD5876C17336ECF" modified="2005-12-06" version="1">MTTSMFNAKLLPTAPSAAVVVVRVVVVVGNAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q329H0</accession>
    <name>YJDP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein YjdP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">yjdP</name>
        <name type="ordered locus">SDY_4125</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000806199.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405526.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329H0"/>
    <dbReference type="STRING" id="300267.SDY_4125"/>
    <dbReference type="EnsemblBacteria" id="ABB64035">
        <property type="protein sequence ID" value="ABB64035"/>
        <property type="gene ID" value="SDY_4125"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4125"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4849"/>
    <dbReference type="HOGENOM" id="CLU_176118_0_0_6"/>
    <dbReference type="OMA" id="WQREVND"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000228852" description="Uncharacterized protein YjdP">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="109" mass="13351" checksum="4F643401C20F55CD" modified="2005-12-06" version="1" precursor="true">MKPYSTLFLFTLLTLTTVPAQADIIDDTIGNIQQAINDAYNPDHGRDYEDSRDDGWQREVSDDRRRQYDDRRRQFEDRRRQLDDRQHQLDQERRQLEDEERRMEDEYGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q329K7</accession>
    <name>RPOZ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="1">RNAP omega subunit</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoZ</name>
        <name type="ordered locus">SDY_4081</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000135058.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405489.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329K7"/>
    <dbReference type="SMR" id="Q329K7"/>
    <dbReference type="STRING" id="300267.SDY_4081"/>
    <dbReference type="EnsemblBacteria" id="ABB63998">
        <property type="protein sequence ID" value="ABB63998"/>
        <property type="gene ID" value="SDY_4081"/>
    </dbReference>
    <dbReference type="GeneID" id="64726409"/>
    <dbReference type="GeneID" id="67517126"/>
    <dbReference type="KEGG" id="sdy:SDY_4081"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4802"/>
    <dbReference type="HOGENOM" id="CLU_125406_5_3_6"/>
    <dbReference type="OMA" id="NVDNRFQ"/>
    <dbReference type="PRO" id="PR:Q329K7"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000237505" description="DNA-directed RNA polymerase subunit omega">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <sequence length="91" mass="10237" checksum="4DE7E81EF670D887" modified="2005-12-06" version="1">MARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q329L7</accession>
    <name>DUT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="1">dUTPase</shortName>
            <ecNumber evidence="1">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dut</name>
        <name type="ordered locus">SDY_4070</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405479.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329L7"/>
    <dbReference type="SMR" id="Q329L7"/>
    <dbReference type="STRING" id="300267.SDY_4070"/>
    <dbReference type="EnsemblBacteria" id="ABB63988">
        <property type="protein sequence ID" value="ABB63988"/>
        <property type="gene ID" value="SDY_4070"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4070"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4786"/>
    <dbReference type="HOGENOM" id="CLU_068508_1_1_6"/>
    <dbReference type="OMA" id="YAAFVHP"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000231429" description="Deoxyuridine 5'-triphosphate nucleotidohydrolase">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <sequence length="151" mass="16156" checksum="32FA3A566AAB9204" modified="2005-12-06" version="1">MKKIDVKILDPRVGKEFPLPTYATSGSAGLDLRACLDDAVELAPGDTTLVPTGLAIHIADPSLAAMMLPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISVWNRGQDSFTIQPGERIAQMIFVPVVQAEFNLVEDFDATDRGEGGFGHSGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Z8</accession>
    <name>Q329Z8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yigI</name>
        <name evidence="2" type="ordered locus">SDY_3923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Z8"/>
    <dbReference type="STRING" id="300267.SDY_3923"/>
    <dbReference type="EnsemblBacteria" id="ABB63857">
        <property type="protein sequence ID" value="ABB63857"/>
        <property type="gene ID" value="SDY_3923"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3923"/>
    <dbReference type="HOGENOM" id="CLU_089876_7_2_6"/>
    <dbReference type="OMA" id="RMGTIDM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="63"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="161" mass="17900" checksum="18B57803EBF25B40" modified="2005-12-06" version="1">MKCKDDMSAVLTAEQALKLVGEMFVYHMPFNRALGMELERYEKEFAQLAFKNQPMMVGNWAQSILHGGGIASVLDVAAGLVCVGSTLTRHETISEDELRQRLSRMGTIDLRVDYLRPSRGERFTATSSLLRAGNKVAVARVELHNEEQLYIASATATYMVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AB8</accession>
    <name>ARGE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetylornithine deacetylase</fullName>
            <shortName evidence="1">AO</shortName>
            <shortName evidence="1">Acetylornithinase</shortName>
            <ecNumber evidence="1">3.5.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetylornithinase</fullName>
            <shortName evidence="1">NAO</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argE</name>
        <name type="ordered locus">SDY_3792</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids. Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(2)-acetyl-L-ornithine = acetate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="3.5.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) or Co(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family. ArgE subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005015828.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405228.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AB8"/>
    <dbReference type="SMR" id="Q32AB8"/>
    <dbReference type="STRING" id="300267.SDY_3792"/>
    <dbReference type="MEROPS" id="M20.974"/>
    <dbReference type="EnsemblBacteria" id="ABB63737">
        <property type="protein sequence ID" value="ABB63737"/>
        <property type="gene ID" value="SDY_3792"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3792"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4481"/>
    <dbReference type="HOGENOM" id="CLU_021802_2_4_6"/>
    <dbReference type="OMA" id="CAHQPGE"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008777">
        <property type="term" value="F:acetylornithine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01108">
        <property type="entry name" value="ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010169">
        <property type="entry name" value="AcOrn-deacetyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF1">
        <property type="entry name" value="PTHR43808:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01892">
        <property type="entry name" value="AcOrn-deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000065062" description="Acetylornithine deacetylase">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01108"/>
        </source>
    </evidence>
    <sequence length="383" mass="42307" checksum="D306D4FEAB322410" modified="2005-12-06" version="1">MKNKLPPFIEIYRALIATPSISATEEALDQSNADLITLLADWFKNLGFNVEVQPVPGTRNKFNMLASTGQGAGGLLLAGHTDTVPFDDGRWTRDPFTLTEHDGKLYGLGTADMKGFFAFILDALRDVDVTKLKKPLYILATADEETSMAGARYFAETTALRPDCAIIGEPTSLQPVRAHKGHISNAIRIQGQSGHSSDPARGVNAIELMHDAIGHILQLRDSLKERYHYEAFTVPYPTLNLGHIHGGDASNRICACCELHMDIRPLPGMTLNELNGLLNDALAPVSERWPGRLTVDELHPPIPGYECPPNHQLVEVVEKLLGAKTEVVNYCTEAPFIQTLCPTLVLGPGSINQAHQPDEYLETRFIKPTRELITQVIHHFCWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AE7</accession>
    <name>Q32AE7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">murI</name>
        <name evidence="8" type="ordered locus">SDY_3761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AE7"/>
    <dbReference type="STRING" id="300267.SDY_3761"/>
    <dbReference type="EnsemblBacteria" id="ABB63708">
        <property type="protein sequence ID" value="ABB63708"/>
        <property type="gene ID" value="SDY_3761"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3761"/>
    <dbReference type="HOGENOM" id="CLU_052344_2_0_6"/>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="289" mass="31577" checksum="962F89A228207664" modified="2005-12-06" version="1">MRQSMATKLQDGNTPCLAATPSEPRPTVLVFDSGVGGLSVYDEIRHLLPDLHYIYAFDNVAFPYGEKSEAFIVERVVAIVTAVQERYPLALAVVACNTASTVSLPALREKFDFPVVGVVPAIKPAARLTANGIVGLLATRGTVKRSYTHELIARFANECQIEMLGSAEMVELAEAKLHGEDVSLDALKRILRPWLRMKEPPDTVVLGCTHFPLLQEELLQVLPEGTRLVDSGAAIARRTAWLLEHEAPDAKSADANIAFCMAMTPEAEQLLPVLQRYGFETLEKLAVLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AH9</accession>
    <name>PUR9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="1">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">IMP cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">purH</name>
        <name type="ordered locus">SDY_3720</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="1"/>
    <dbReference type="EC" id="3.5.4.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001187534.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405167.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AH9"/>
    <dbReference type="SMR" id="Q32AH9"/>
    <dbReference type="STRING" id="300267.SDY_3720"/>
    <dbReference type="EnsemblBacteria" id="ABB63676">
        <property type="protein sequence ID" value="ABB63676"/>
        <property type="gene ID" value="SDY_3720"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3720"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4411"/>
    <dbReference type="HOGENOM" id="CLU_016316_5_2_6"/>
    <dbReference type="OMA" id="WRVAKFV"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000018955" description="Bifunctional purine biosynthesis protein PurH">
        <location>
            <begin position="1"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01202"/>
        </source>
    </evidence>
    <sequence length="529" mass="57387" checksum="6596DAB03E5D0D93" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AI3</accession>
    <name>Q32AI3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AI3"/>
    <dbReference type="EnsemblBacteria" id="ABB63672">
        <property type="protein sequence ID" value="ABB63672"/>
        <property type="gene ID" value="SDY_3712"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3712"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="8962" checksum="9E942B20002EDE95" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITQNFRFQFSHRAGTRSTEPFSGGGNPLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AJ7</accession>
    <name>GPH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <shortName evidence="1">PGP</shortName>
            <shortName evidence="1">PGPase</shortName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SDY_3694</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phosphoglycolate + H2O = glycolate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="EC" id="3.1.3.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001031704.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405149.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AJ7"/>
    <dbReference type="SMR" id="Q32AJ7"/>
    <dbReference type="STRING" id="300267.SDY_3694"/>
    <dbReference type="PRIDE" id="Q32AJ7"/>
    <dbReference type="EnsemblBacteria" id="ABB63658">
        <property type="protein sequence ID" value="ABB63658"/>
        <property type="gene ID" value="SDY_3694"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3694"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4382"/>
    <dbReference type="HOGENOM" id="CLU_045011_19_1_6"/>
    <dbReference type="OMA" id="YLCGKFG"/>
    <dbReference type="UniPathway" id="UPA00865">
        <property type="reaction ID" value="UER00834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046295">
        <property type="term" value="P:glycolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00495">
        <property type="entry name" value="GPH_hydrolase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006346">
        <property type="entry name" value="PGPase/MupP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037512">
        <property type="entry name" value="PGPase_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01449">
        <property type="entry name" value="PGP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0868">Chloride</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000238178" description="Phosphoglycolate phosphatase">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00495"/>
        </source>
    </evidence>
    <sequence length="252" mass="27403" checksum="9D4D665BD264FEEF" modified="2005-12-06" version="1">MNKFEDIRGVAFDLDGTLVDSALGLAAAVDMALYALKLPIAGEERVITWIGNGADVLMERALTWARQERATLRKTMGKPPVDDDIPAEEQVRILRKLFDRYYGEVAEEGTFLFPHVADTLGALQAKGLPLGLVTNKPTPFVAPLLEALDIAKYFSVVIGGDDVQNKKPHPDPLLLVAERMGIAPQQMLFVGDSRNDIQAAKAAGCPSVGLTYGYNYGEAIDLSQPDVIYQSINDLLPALGLPHSENQESKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AS7</accession>
    <name>Q32AS7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High-affinity leucine-specific transport system periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livK</name>
        <name evidence="5" type="ordered locus">SDY_3607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378891.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405069.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AS7"/>
    <dbReference type="STRING" id="300267.SDY_3607"/>
    <dbReference type="EnsemblBacteria" id="ABB63578">
        <property type="protein sequence ID" value="ABB63578"/>
        <property type="gene ID" value="SDY_3607"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3607"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4283"/>
    <dbReference type="HOGENOM" id="CLU_027128_6_0_6"/>
    <dbReference type="OMA" id="YGVGFEQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220993" evidence="3">
        <location>
            <begin position="24"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="26"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="369" mass="39360" checksum="A4016F89191FC7E6" modified="2005-12-06" version="1">MKRNAKTIIAGMIALAISHTALADDIKVAVVGAMSGPIAQWGDMEFNGARQAIKDINAKGGIKGDKLVGVEYDDACDPKQAVAVANKIVNDGIKYVIGHLCSSSTQPASDIYEDEGILMISPGATNPELTQRGYQHIMRTAGLDSSQGPTAAKYILETVKPQRIAIIHDKQQYGEGLARSVQDGLKAANANVVFFDGITAGEKDFSALIARLKKENIDFVYYGGYYPEMGQMLRQARSVGLKTQFMGPEGVGNASLSNIAGDAAEGMLVTMPKRYDQDPANQGIVDALKADKKDPSGPYVWITYAAVQSLATALERTGSDEPLALVKDLKANGANTVIGPLIWDEKGDLKGFDFGVFQWHADGSSTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AT7</accession>
    <name>Q32AT7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">ggt</name>
        <name evidence="7" type="ordered locus">SDY_3595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000595158.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405059.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AT7"/>
    <dbReference type="STRING" id="300267.SDY_3595"/>
    <dbReference type="MEROPS" id="T03.001"/>
    <dbReference type="EnsemblBacteria" id="ABB63568">
        <property type="protein sequence ID" value="ABB63568"/>
        <property type="gene ID" value="SDY_3595"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3595"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4268"/>
    <dbReference type="HOGENOM" id="CLU_014813_0_3_6"/>
    <dbReference type="OMA" id="KATKNMF"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220997" description="Glutathione hydrolase proenzyme" evidence="6">
        <location>
            <begin position="26"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="581" mass="62109" checksum="5A2C021746F64350" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AW1</accession>
    <name>Q32AW1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yhiN</name>
        <name evidence="1" type="ordered locus">SDY_3570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000439209.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405035.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AW1"/>
    <dbReference type="STRING" id="300267.SDY_3570"/>
    <dbReference type="EnsemblBacteria" id="ABB63544">
        <property type="protein sequence ID" value="ABB63544"/>
        <property type="gene ID" value="SDY_3570"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3570"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4238"/>
    <dbReference type="HOGENOM" id="CLU_025174_2_0_6"/>
    <dbReference type="OMA" id="RCNFTNM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="400" mass="43659" checksum="B24DE7CF83BF7464" modified="2005-12-06" version="1">MERFDAIIIGAGAAGMFCSALAGQAGRRVLLIDNGKKPGRKILMSGGGRCNFTNLYVEPGAYLSQNSHFCKSALARFTQWDFIDLVNKHGIAWHEKTLGQLFCDDSAQQIVDMLVDECEKGNVAVRLRSEVLSVEKDDTGFTLELNGMTVGCEKLVIATGGLSMPGLGASPFGYKIAEQFGLNVLSTRAGLVPFTLHKPLLEELQVLAGVAVPSVITAENGTVFRENLLFTHRGLSGPAVLQISSYWQPGEFVSINLLPDVGLETFLNEQRNAHPNQSLKNTLAVHLPKRLVERLQQLGQIPDVSLKQLNVRDQQALISTLTDWRVQPNGTEGYRTAEVTLGGVDTNELSSRTMEARKVPGLYFIGEVMDVTGWLGGYNFQWAWSSAWACAQDLIAAKSC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-07-13" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AW5</accession>
    <name>DTPB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptide and tripeptide permease B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtpB</name>
        <name type="ordered locus">SDY_3566</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Proton-dependent permease that transports di- and tripeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpB subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="ABB63540" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63540.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AW5"/>
    <dbReference type="SMR" id="Q32AW5"/>
    <dbReference type="STRING" id="300267.SDY_3566"/>
    <dbReference type="EnsemblBacteria" id="ABB63540">
        <property type="protein sequence ID" value="ABB63540"/>
        <property type="gene ID" value="SDY_3566"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3566"/>
    <dbReference type="HOGENOM" id="CLU_004790_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015333">
        <property type="term" value="F:peptide:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042937">
        <property type="term" value="F:tripeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01879">
        <property type="entry name" value="PTR2_DtpB_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023778">
        <property type="entry name" value="AA/pep_transptr_DtpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
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    </dbReference>
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        <property type="entry name" value="yjdL_sub1_fam"/>
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    </dbReference>
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        <property type="entry name" value="PTR2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0571">Peptide transport</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000395188" description="Dipeptide and tripeptide permease B">
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            <begin position="1"/>
            <end position="489"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
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            <begin position="49"/>
            <end position="52"/>
        </location>
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            <end position="73"/>
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            <end position="82"/>
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            <end position="106"/>
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            <end position="172"/>
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            <end position="193"/>
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            <end position="210"/>
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            <end position="233"/>
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            <end position="254"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
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            <begin position="289"/>
            <end position="311"/>
        </location>
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            <begin position="312"/>
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        </location>
    </feature>
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        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
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        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="380"/>
        </location>
    </feature>
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        <location>
            <begin position="381"/>
            <end position="401"/>
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        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
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        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
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        <location>
            <begin position="433"/>
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        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="489" mass="53325" checksum="549875B688CC5FC7" modified="2010-07-13" version="2">MNTTTPMGMLQQPRPFFMIFFVELWERFGYYGVQGVLAVFFVKQLGFSQEQAFVTFGAFAALVYGLISIGGYVGDHLLGTKRTIVLGALVLAIGYFMTGLSLLKPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKAPRLDGAFTLFYMSINIGSLIALSLAPVIADRFGYSVTYNLCGAGLIIALLVYIACRGMVKDIGSEPDFRPMSFSKLLYVLLGSVVMIFVCAWLMHNVEVANLVLIVLSIVVTIIFFRQAFKLDKTGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAINNVHHEILGFSINPVSFQALNPFWVVLASPILAGIYTHLGSKGKDLSMPMKFTLGMFMCSLGFLTAAAAGMWFADAQGLTSPWFIVLVYLFQSLGELFISALGLAMVAALVPQHLMGFILGISFLTQAAAFLLGGYVATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVVMLLMVPWLKRMIAAPESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AZ5</accession>
    <name>Q32AZ5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ARAC-type regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhiX</name>
        <name evidence="3" type="ordered locus">SDY_3533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AZ5"/>
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    <dbReference type="EnsemblBacteria" id="ABB63510">
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        <property type="gene ID" value="SDY_3533"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3533"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4188"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
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        <property type="entry name" value="HTH_AraC"/>
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        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="145"/>
            <end position="242"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="274" mass="31502" checksum="1CB3A5BF8CC1BD38" modified="2005-12-06" version="1">MQSLHGNCLIAYARHKYILTMVNGEYRYFNGGDLVFADASQIRVDKCVENFVLVSRDTLSLFLPMLKEEALNLHAHKKVSSLLVHHCGRDIPVFQEVSQLSQNKNLRYAEMLRKRALIFALLSVFLEDEHFIPLLLNVLQPNMRTRVCTVINNNIVHEWTLARIASELLMSPSLLKKKLREEETSYSQLLTECRMKRALQLIVIHVFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQERSAQRLSNRDSAASIVAQGNFYGADCSAEGIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BA5</accession>
    <name>Q32BA5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="5">3.4.21.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">degQ</name>
        <name evidence="7" type="ordered locus">SDY_3410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.</text>
            <dbReference type="EC" id="3.4.21.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001316675.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404891.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BA5"/>
    <dbReference type="STRING" id="300267.SDY_3410"/>
    <dbReference type="MEROPS" id="S01.274"/>
    <dbReference type="EnsemblBacteria" id="ABB63400">
        <property type="protein sequence ID" value="ABB63400"/>
        <property type="gene ID" value="SDY_3410"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3410"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4068"/>
    <dbReference type="HOGENOM" id="CLU_020120_1_1_6"/>
    <dbReference type="OMA" id="IIGINRQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010602610" description="Periplasmic serine endoprotease DegP-like" evidence="5">
        <location>
            <begin position="28"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="258"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="355"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="455" mass="47219" checksum="6A17FE74312B7053" modified="2005-12-06" version="1">MKKQTQLLSALALSVGLTLSASFQAVASIPGQVADQAPLPSLAPMLEKVLPAVVSVRVEGTASQGQKIPEEFKKFFGDDLPDQPAQPFEGLGSGVIINASKGYVLTNNHVINQAQKISIQLNDGREFDAKLIGSDDQSDIALLQIQNPSKLTQIAIADSDKLRVGDFAVAVGNPFGLGQTATSGIVSALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSVGIGFAIPSNMARTLAQQLIDFGEIKRGLLGIKGTEMSADIAKAFNLDVQRGAFVSEVLPGSGSAKAGIKAGDIITSLNGKPLNSFAELRSRIATTEPGTKVKLGLLRNGKPLEVEVTLDTSTSSSASAEMITPALEGATLSDGQLKDGGKGIKIDEVVKGSPAAQAGLQKDDVIIGVNRDRVNSIAEMRKVLAAKPAIIALQIVRGNESIYLLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BE9</accession>
    <name>Q32BE9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhbE</name>
        <name evidence="6" type="ordered locus">SDY_3365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000813017.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404847.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BE9"/>
    <dbReference type="STRING" id="300267.SDY_3365"/>
    <dbReference type="EnsemblBacteria" id="ABB63356">
        <property type="protein sequence ID" value="ABB63356"/>
        <property type="gene ID" value="SDY_3365"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3365"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4019"/>
    <dbReference type="HOGENOM" id="CLU_074108_1_0_6"/>
    <dbReference type="OMA" id="FCGANTL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="5">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="5">
        <location>
            <begin position="159"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="321" mass="34903" checksum="9D1E6ED39305E77D" modified="2005-12-06" version="1">MKQQAGIGILLALTTAICWGALPIAMKQVLEVMEPPTIVFYRFLMASIGLGAILAVKKRLPPLRVFRKPRRLILLAVATAGLFGNFILFSSSLQYLSPTASQVIGQLSPVGMMVASVFILKEKMRSTQVVGALMLLSGLVMFFNTSLVEIFTKLTDYTWGVIFGVGAATVWVSYGVAQKVLLRRLASPQILFLLYALCTIALFPLAKPGVIAQLSHWQLACLIFCGLNTLVGYGALAEAMARWQAAQVSAIITLTPLFTLFFSDLLSLAWPDFFARPMLNLLGYLGAFVVVAGAMYSAIGHRIWGGLRKHTTVVSQPRAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BP2</accession>
    <name>Q32BP2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygjK</name>
        <name evidence="2" type="ordered locus">SDY_3263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000695521.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404754.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BP2"/>
    <dbReference type="STRING" id="300267.SDY_3263"/>
    <dbReference type="CAZy" id="GH63">
        <property type="family name" value="Glycoside Hydrolase Family 63"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63263">
        <property type="protein sequence ID" value="ABB63263"/>
        <property type="gene ID" value="SDY_3263"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3263"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3902"/>
    <dbReference type="HOGENOM" id="CLU_015270_0_1_6"/>
    <dbReference type="OMA" id="WLEEMYP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="PTHR23403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220629" evidence="1">
        <location>
            <begin position="23"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="783" mass="88573" checksum="1B755CB394923C69" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BQ7</accession>
    <name>Q32BQ7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="2">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ygiG</name>
        <name evidence="4" type="ordered locus">SDY_3241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404739.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BQ7"/>
    <dbReference type="STRING" id="300267.SDY_3241"/>
    <dbReference type="EnsemblBacteria" id="ABB63248">
        <property type="protein sequence ID" value="ABB63248"/>
        <property type="gene ID" value="SDY_3241"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3241"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3871"/>
    <dbReference type="HOGENOM" id="CLU_112632_0_2_6"/>
    <dbReference type="OMA" id="GIYEWEK"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FolB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="123" mass="13751" checksum="D85807EE47A38A55" modified="2005-12-06" version="1">MMDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETVVSHVEGARFALVERVAEEVAELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKENN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BR9</accession>
    <name>GLGS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Surface composition regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgS</name>
        <name type="ordered locus">SDY_3228</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major determinant of cell surface composition. Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GlgS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000401250.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404727.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BR9"/>
    <dbReference type="SMR" id="Q32BR9"/>
    <dbReference type="STRING" id="300267.SDY_3228"/>
    <dbReference type="EnsemblBacteria" id="ABB63236">
        <property type="protein sequence ID" value="ABB63236"/>
        <property type="gene ID" value="SDY_3228"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3228"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3854"/>
    <dbReference type="HOGENOM" id="CLU_185971_0_0_6"/>
    <dbReference type="OMA" id="HRSWFCK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902201">
        <property type="term" value="P:negative regulation of bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900191">
        <property type="term" value="P:negative regulation of single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00525">
        <property type="entry name" value="GlgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015065">
        <property type="entry name" value="GlgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036295">
        <property type="entry name" value="GlgS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08971">
        <property type="entry name" value="GlgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109747">
        <property type="entry name" value="SSF109747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264148" description="Surface composition regulator">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7936" checksum="90F61B6FCB66753F" modified="2005-12-06" version="1">MEHSLNSLNNFDFLARSFARMHAEGRPVDILAVTGNMDEEHRTWFCARYAWYCQQMMQTRELELEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BU0</accession>
    <name>Q32BU0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribose pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-ribose diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ADP-ribose phosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Adenosine diphosphoribose pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yqiE</name>
        <name evidence="13" type="ordered locus">SDY_3206</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:10412"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.13" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000917117.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404706.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BU0"/>
    <dbReference type="SMR" id="Q32BU0"/>
    <dbReference type="STRING" id="300267.SDY_3206"/>
    <dbReference type="EnsemblBacteria" id="ABB63215">
        <property type="protein sequence ID" value="ABB63215"/>
        <property type="gene ID" value="SDY_3206"/>
    </dbReference>
    <dbReference type="GeneID" id="66673067"/>
    <dbReference type="KEGG" id="sdy:SDY_3206"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3831"/>
    <dbReference type="HOGENOM" id="CLU_062658_6_1_6"/>
    <dbReference type="OMA" id="TIIALQW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004385">
        <property type="entry name" value="NDP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00052">
        <property type="entry name" value="TIGR00052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="55"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="209" mass="23667" checksum="2CF77EA9D63B9615" modified="2005-12-06" version="1">MLKPDNLPVTFGKNDVEIIARETLYRGFFSLDLYRFRHRLFNGQMSHEVRREIFERGHAAVLLPFDPVRDEVVLIEQIRIAAYDTSETPWLLEMVAGMIEEGESVEDVARREAIEEAGLIVKRTKPVLSFLASPGGTSERSSIMVGEVDATTASGIHGLADENEDIRVHVVSREQAYQWVEEGKIDNAASVIALQWLQLHHQALKNEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BX1</accession>
    <name>Q32BX1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0149 protein YgfB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">ygfB</name>
        <name evidence="2" type="ordered locus">SDY_3172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0149 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BX1"/>
    <dbReference type="STRING" id="300267.SDY_3172"/>
    <dbReference type="EnsemblBacteria" id="ABB63184">
        <property type="protein sequence ID" value="ABB63184"/>
        <property type="gene ID" value="SDY_3172"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3172"/>
    <dbReference type="HOGENOM" id="CLU_085336_1_0_6"/>
    <dbReference type="OMA" id="WVNHFIS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00346">
        <property type="entry name" value="UPF0149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011978">
        <property type="entry name" value="UPF0149"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036255">
        <property type="entry name" value="YgfB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03695">
        <property type="entry name" value="UPF0149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101327">
        <property type="entry name" value="SSF101327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02292">
        <property type="entry name" value="ygfB_yecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="194" mass="21504" checksum="9858D50897444C4F" modified="2005-12-06" version="1">MLMSIQNEMPSYNEMNQYLNQQGTGLTPAEMHGLISGMICGGNDDSSWLPLLHDLTNEGMAFGHELAQALRKMHSATSDALQDDGFLFQLYLPDGDDVSVFDRADALAGWVNHFLLGLGVTQPKLDKVTGETGEAIDDLRNIAQLGYDEDEDQEELEMSLEEIIEYVRVAALLCHDTFTHPQPTAPEVQKPTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BY5</accession>
    <name>Q32BY5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="12">FBP aldolase</shortName>
            <ecNumber evidence="5 12">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fba</name>
        <name evidence="13" type="ordered locus">SDY_3157</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000034372.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404661.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BY5"/>
    <dbReference type="SMR" id="Q32BY5"/>
    <dbReference type="STRING" id="300267.SDY_3157"/>
    <dbReference type="EnsemblBacteria" id="ABB63170">
        <property type="protein sequence ID" value="ABB63170"/>
        <property type="gene ID" value="SDY_3157"/>
    </dbReference>
    <dbReference type="GeneID" id="66673198"/>
    <dbReference type="KEGG" id="sdy:SDY_3157"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3770"/>
    <dbReference type="HOGENOM" id="CLU_036923_0_0_6"/>
    <dbReference type="OMA" id="QAYCAEK"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="10">
        <location>
            <begin position="266"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="10">
        <location>
            <begin position="287"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="359" mass="39147" checksum="7A076D9EA62FBEC4" modified="2005-12-06" version="1">MSKIFDFVKPGVITGDDVQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGGASFIAGKGVKSDVPQGAAILGAISGAHHVHQMAEHYGVPVILHTDHCAKKLLPWIDGLLDAGEKHFAATGKPLFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGCTGGEEDGVDNSHMDASALYTQPEDVDYAYTELSKISPRFTIAASFGNVHGVYKPGNVVLTPTILRDSQEYVSKKHNLPHNSLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANEAYLQGQLGNPKGEDQPNKKYYDPRVWLRAGQTSMIARLEKAFQELNAIDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BZ1</accession>
    <name>Q32BZ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP-binding protein of ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BZ1"/>
    <dbReference type="STRING" id="300267.SDY_3151"/>
    <dbReference type="EnsemblBacteria" id="ABB63164">
        <property type="protein sequence ID" value="ABB63164"/>
        <property type="gene ID" value="SDY_3151"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3151"/>
    <dbReference type="HOGENOM" id="CLU_1936689_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="130" mass="14169" checksum="D611485302272EBD" modified="2005-12-06" version="1">MVTLEQFRYCPTHSTHPPFCYDFHYVKPGMVAIFGDNSSGKSTLAQLMAGWYPDFLPGDITGTGTLLGTPIGHLPLNEQSATIQLVQQLPYLQLSGCTFSVEEEVAFGPENLCLAEAEIMARIDAALTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C10</accession>
    <name>Q32C10_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqgD</name>
        <name evidence="1" type="ordered locus">SDY_3131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404636.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C10"/>
    <dbReference type="EnsemblBacteria" id="ABB63145">
        <property type="protein sequence ID" value="ABB63145"/>
        <property type="gene ID" value="SDY_3131"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3131"/>
    <dbReference type="HOGENOM" id="CLU_189034_0_0_6"/>
    <dbReference type="OMA" id="IMRIYTL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9562" checksum="5DE5F9B7E240F9F2" modified="2005-12-06" version="1">MVADPTTTLQVKNTGSLSVNRYGWINIWMAILGQFFTRFPLFFESCLILLKTWLEIFPDNAGILRIYLLQFSAIVGYKTRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C63</accession>
    <name>Q32C63_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrogenase (acceptor)</fullName>
            <ecNumber evidence="6">1.12.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NiFe hydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">SDY_3076</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>A + H2 = AH2</text>
            <dbReference type="Rhea" id="RHEA:12116"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:18276"/>
            <dbReference type="EC" id="1.12.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.12.99.6" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000145424.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404583.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C63"/>
    <dbReference type="STRING" id="300267.SDY_3076"/>
    <dbReference type="EnsemblBacteria" id="ABB63092">
        <property type="protein sequence ID" value="ABB63092"/>
        <property type="gene ID" value="SDY_3076"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3076"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3683"/>
    <dbReference type="HOGENOM" id="CLU_046107_0_1_6"/>
    <dbReference type="OMA" id="VPGCPIQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009375">
        <property type="term" value="C:ferredoxin hydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033748">
        <property type="term" value="F:hydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027394">
        <property type="entry name" value="Cytochrome-c3_hydrogenase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037148">
        <property type="entry name" value="NiFe-Hase_small_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001821">
        <property type="entry name" value="NiFe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30013">
        <property type="entry name" value="PTHR30013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14720">
        <property type="entry name" value="NiFe_hyd_SSU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000310">
        <property type="entry name" value="NiFe_hyd_ssu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00391">
        <property type="entry name" value="hydA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_q6" evidence="16">
        <location>
            <begin position="59"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="NiFe_hyd_SSU_C" evidence="17">
        <location>
            <begin position="224"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB63092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="372" mass="39622" checksum="15495D6DF884683A" modified="2005-12-06" version="1">MTGDNTLIHSHGINRRDFMKLCAALAATMGLSSKAAAETAESVTNPQRPPVIWIGAQECTGCTESLLRATHPTVENLVLETISLEYHEVLSAAFGHQVEENKHNALEKYKGQYVLVVDGSIPLKDNGIYCMVAGEPIVDHIRKAAEGAAAIIAIGSCSAWGGVAAAGVNPTGAVSLQEVLPGKTVINIPGCPPNPHNFLATVAHIITYGKPPKLDDKNRPTFAYGRLIHEHCERRPHFDAGRFAKEFGDEGHREGWCLYHLGCKGPETYGNCSTLQFCDVGGVWPVAIGHPCYGCNEEGIGFHKGIHQLANVENQTPRSQKPDVNAKEGGNVSAGAIGLLGGVVGLVAGVSVMAVRELGRQQKKDNADSRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CJ8</accession>
    <name>Q32CJ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Potential molybdenum-pterin-binding-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_2931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404448.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CJ8"/>
    <dbReference type="STRING" id="300267.SDY_2931"/>
    <dbReference type="EnsemblBacteria" id="ABB62957">
        <property type="protein sequence ID" value="ABB62957"/>
        <property type="gene ID" value="SDY_2931"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2931"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3521"/>
    <dbReference type="HOGENOM" id="CLU_118993_0_1_6"/>
    <dbReference type="OMA" id="CGLNFSA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="147" mass="14998" checksum="CB047B48C4E17DC0" modified="2005-12-06" version="1">MKGGSMAVSARNQLTGTVSAVAMGTVNDEVELTLAGGAKLVAIVTHSSQQALGLAKGKEAIALIKAPWVTLATEDCGLKFSARNQFAGSVSTITEGAVNATVHIKTDAGFEIVAVVTNESQDEMKLTTGSRVIALIKASAILIATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CL1</accession>
    <name>Q32CL1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HycH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hycH</name>
        <name evidence="1" type="ordered locus">SDY_2915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001291937.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404435.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CL1"/>
    <dbReference type="STRING" id="300267.SDY_2915"/>
    <dbReference type="EnsemblBacteria" id="ABB62944">
        <property type="protein sequence ID" value="ABB62944"/>
        <property type="gene ID" value="SDY_2915"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2915"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3502"/>
    <dbReference type="HOGENOM" id="CLU_121340_0_0_6"/>
    <dbReference type="OMA" id="YLMVRRH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010005">
        <property type="entry name" value="Formate_DH_maturation_HycH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07450">
        <property type="entry name" value="HycH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="136" mass="15393" checksum="298D81AA4182A992" modified="2005-12-06" version="1">MSEKVVFSQLSRKFIDGNDATPAEAQQVVYYSLAIGHHLGVIDCLEAALTCPWDEYLAWIATLEAGSEARRKMEGVPKYGEIVIDINHVPMLANAFDKARAAQTSQQKEWSTMLLSMLHDIHQENAIYLMVRRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CP2</accession>
    <name>Q32CP2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_2877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000445646.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404404.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CP2"/>
    <dbReference type="STRING" id="300267.SDY_2877"/>
    <dbReference type="EnsemblBacteria" id="ABB62913">
        <property type="protein sequence ID" value="ABB62913"/>
        <property type="gene ID" value="SDY_2877"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2877"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3459"/>
    <dbReference type="HOGENOM" id="CLU_065777_3_1_6"/>
    <dbReference type="OMA" id="FIVLFME"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="245" mass="26110" checksum="00AAF2DFDFC8577D" modified="2005-12-06" version="1">MESPTPQPALGSATFMEGCKDSLPIVISYIPVAFAFGLNATRLGFSPLESVFFSCIIYAGASQFVITAMLAAGSSLWVAALTVMAMDVRHVLYGPSLRSRIIQRLQKSKTALWAFGLTDEVFAAATAKLVRNNRRWSENWMIGIAFSSWSSWVFGTVIGAFSGSGLLQGYPAVEAALGFMLPALFMSFLLASFQRKQSLCVTAALVGALAGVTLFSIPVAILAGIVCGCLTALIQAFWQGAPDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CP6</accession>
    <name>Q32CP6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding component of transport system for glycine, betaine and proline</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proV</name>
        <name evidence="8" type="ordered locus">SDY_2872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404400.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CP6"/>
    <dbReference type="STRING" id="300267.SDY_2872"/>
    <dbReference type="EnsemblBacteria" id="ABB62909">
        <property type="protein sequence ID" value="ABB62909"/>
        <property type="gene ID" value="SDY_2872"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2872"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3451"/>
    <dbReference type="HOGENOM" id="CLU_000604_2_1_6"/>
    <dbReference type="OMA" id="GQIFVVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="284"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="2"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="341" mass="37502" checksum="0783876CEE5DB414" modified="2005-12-06" version="1">MGLSGSGKSTMVRLLNRLIEPTRGQVLIDGVDIAKISDAELREVRRKKIAMVFQSFALMPHMTVLDNTAFGMELAGINAEERREKAIDALRQVGLENYAHSYPDELSGGMRQRVGLARALAINPDILLMDEAFSALDPLIRTEMQDELVKLQAKHQRTIVFISHDLDEAMRIGDRIAIMQNGEVVQVGTPDEILNNPANDYVRTFFRGVDISQVFSAKDIARRTPNGLIRKTPGFGPRSALKLLQDEDREYGYVIERGNKFVGAVSIDSLKTALTQQQGLDAALIDAPLAVDAQTPLSELLSHVGQAPCAVPVVDEDQQYVGIISKGMLLRALDREGVNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CR1</accession>
    <name>Q32CR1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000137286.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404385.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CR1"/>
    <dbReference type="STRING" id="300267.SDY_2857"/>
    <dbReference type="EnsemblBacteria" id="ABB62894">
        <property type="protein sequence ID" value="ABB62894"/>
        <property type="gene ID" value="SDY_2857"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2857"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3432"/>
    <dbReference type="HOGENOM" id="CLU_097806_6_4_6"/>
    <dbReference type="OMA" id="CILANEE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="99" mass="10623" checksum="7359A43B62DB1F83" modified="2005-12-06" version="1">MTELAQLQASAEQAAALLKAMSHPKRLLILCMLSGSPGTSVGELTRITGLSASATSQHLARMRDEGLINSQRDAQRILYSIKNEAVNAIIATLKNVYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CW2</accession>
    <name>Q32CW2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CW2"/>
    <dbReference type="EnsemblBacteria" id="ABB62843">
        <property type="protein sequence ID" value="ABB62843"/>
        <property type="gene ID" value="SDY_2800"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2800"/>
    <dbReference type="HOGENOM" id="CLU_1065161_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="261" mass="28863" checksum="0867151CFC162BF9" modified="2005-12-06" version="1">MPRTVTHNPDSPNNDDVLAASEKWDACKPPYTSAHMKICVAAAKIILAASGVARRSKYEKENYLRIDFSKAGKVTFYAEFPKKMGLKGKKLGEWPELAIQLAREKALGMADGGLRAESVHAALEMYRDDLKAKVARQKLSPDSFTTYGVRIDRIKATFGEREVFSDVTYNRLVEVLDEWIATRSNNNALELLPSSVGSGSSAHLLFATAAMLPPVCQMIMFPPAYRNLPPHGFLPILNQSPDSGSMLLPAPLYTRRMLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CY9</accession>
    <name>Q32CY9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tail fiber protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404307.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CY9"/>
    <dbReference type="STRING" id="300267.SDY_2773"/>
    <dbReference type="EnsemblBacteria" id="ABB62816">
        <property type="protein sequence ID" value="ABB62816"/>
        <property type="gene ID" value="SDY_2773"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2773"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3342"/>
    <dbReference type="HOGENOM" id="CLU_1288160_0_0_6"/>
    <dbReference type="OMA" id="FRCGFAP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="225" mass="24607" checksum="3B2B4EAEA865EF99" modified="2005-12-06" version="1">MYDITAAIRFAQAGGLYTYNAGFAGAIGGYAKGAILAGVATTAVWLNTTDDNLTDPEGSDSAGWVNLLEDPKRIFLRQKNNLSDLQNKGTARDNLQVYSKEQSDQRYVHQEGDTLSGGLTFENDSILAWIRNTDWAKIGFKNDSDADTDSYMWFETADNGNEYFKWRHRLAGGRVKDLMNLKWDTLNILVNAVINGCLGIGTTNALGGSSIVLGDNDTGFKQNGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-06-13" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D50</accession>
    <name>BAMB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Outer membrane protein assembly factor BamB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bamB</name>
        <name type="ordered locus">SDY_2708</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BamB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001177048.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404246.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D50"/>
    <dbReference type="SMR" id="Q32D50"/>
    <dbReference type="STRING" id="300267.SDY_2708"/>
    <dbReference type="EnsemblBacteria" id="ABB62755">
        <property type="protein sequence ID" value="ABB62755"/>
        <property type="gene ID" value="SDY_2708"/>
    </dbReference>
    <dbReference type="GeneID" id="66673600"/>
    <dbReference type="KEGG" id="sdy:SDY_2708"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3266"/>
    <dbReference type="HOGENOM" id="CLU_027480_0_1_6"/>
    <dbReference type="OMA" id="GRVLWQR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00923">
        <property type="entry name" value="OM_assembly_BamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017687">
        <property type="entry name" value="BamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03300">
        <property type="entry name" value="assembly_YfgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000417689" description="Outer membrane protein assembly factor BamB">
        <location>
            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00923"/>
        </source>
    </evidence>
    <sequence length="392" mass="41857" checksum="E1869B0B77387748" modified="2005-12-06" version="1" precursor="true">MQLRKLLLPGLLSVTLLSGCSLFNSEEDVVKMSPLPTVENQFTPTTAWSTSVGSGIGNFYSNLHPALADNVVYAADRAGLVKALNADDGKEIWSVSLAEKDGWFSKEPALLSGGVTVSGGHVYIGSEKAQVYALNTSDGTVAWQTKVAGEALSRPVVSDGLVLIHTSNGQLQALNEADGAVKWTVNLDMPSLSLRGESAPATAFGAAVVGGDNGRVSAVLMEQGQMIWQQRISQATGSTEIDRLSDVDTTPVVVNGVVFALAYNGNLTALDLRSGQIMWKRELGSVNDFIVDGNRIYLVDQNDRVMALTIDGGVTLWTQSDLLHRLLTSPVLYNGNLVVGDSEGYLHWINVEDGRFVAQQKVDSSGFQTEPVAADGKLLIQAKDGTVYSITR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D53</accession>
    <name>EX7L_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="1">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="1">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xseA</name>
        <name type="ordered locus">SDY_2705</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000937889.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404243.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D53"/>
    <dbReference type="STRING" id="300267.SDY_2705"/>
    <dbReference type="EnsemblBacteria" id="ABB62752">
        <property type="protein sequence ID" value="ABB62752"/>
        <property type="gene ID" value="SDY_2705"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2705"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3263"/>
    <dbReference type="HOGENOM" id="CLU_023625_3_1_6"/>
    <dbReference type="OMA" id="WPAVRFE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000273689" description="Exodeoxyribonuclease 7 large subunit">
        <location>
            <begin position="1"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <sequence length="456" mass="51773" checksum="A48991EB1CAABD32" modified="2005-12-06" version="1">MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAKLQAEGLFDLQYKKPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVAQAIFASRIPVVSAVGHETDVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSTRQRLEMAMDYYLANRTRRFTQIHHRLQQQHPQLRLARQQTMLERLQKRMSFALENQLKRAGQQQQRLTQRLNQQNPQPKIHRAQTRIQQLEYRLAETLRAQLSATRERFGNAVTHLEAVSPLSTLARGYSVTTATDGKVLKKVKQVKAGEMLTTRLEDGWVESEVKNIQPIKKSRKKVH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D55</accession>
    <name>GUAA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="1">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">guaA</name>
        <name type="ordered locus">SDY_2703</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000138271.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404241.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D55"/>
    <dbReference type="SMR" id="Q32D55"/>
    <dbReference type="STRING" id="300267.SDY_2703"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="EnsemblBacteria" id="ABB62750">
        <property type="protein sequence ID" value="ABB62750"/>
        <property type="gene ID" value="SDY_2703"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2703"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3261"/>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_6"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0332">GMP biosynthesis</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000229468" description="GMP synthase [glutamine-hydrolyzing]">
        <location>
            <begin position="1"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="GMPS ATP-PPase" evidence="1">
        <location>
            <begin position="208"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="235"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <sequence length="525" mass="58707" checksum="480F6693F1DD8745" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D62</accession>
    <name>Q32D62_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000076001.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404234.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D62"/>
    <dbReference type="SMR" id="Q32D62"/>
    <dbReference type="STRING" id="300267.SDY_2696"/>
    <dbReference type="EnsemblBacteria" id="ABB62743">
        <property type="protein sequence ID" value="ABB62743"/>
        <property type="gene ID" value="SDY_2696"/>
    </dbReference>
    <dbReference type="GeneID" id="66673630"/>
    <dbReference type="KEGG" id="sdy:SDY_2696"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3254"/>
    <dbReference type="HOGENOM" id="CLU_200567_2_1_6"/>
    <dbReference type="OMA" id="RFNRRMT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022576">
        <property type="entry name" value="YfgG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11119">
        <property type="entry name" value="DUF2633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="63" mass="7462" checksum="FEC1762936E1A43F" modified="2005-12-06" version="1">MSQATSMRKRHRFNSRMTRIVLLISFIFFFGRFIYSSVGAWQHHQSKKEAQQSTLSVESPVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DF0</accession>
    <name>Q32DF0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfeC</name>
        <name evidence="1" type="ordered locus">SDY_2596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000472021.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404146.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DF0"/>
    <dbReference type="STRING" id="300267.SDY_2596"/>
    <dbReference type="EnsemblBacteria" id="ABB62655">
        <property type="protein sequence ID" value="ABB62655"/>
        <property type="gene ID" value="SDY_2596"/>
    </dbReference>
    <dbReference type="GeneID" id="66673733"/>
    <dbReference type="KEGG" id="sdy:SDY_2596"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3133"/>
    <dbReference type="HOGENOM" id="CLU_168146_0_0_6"/>
    <dbReference type="OMA" id="GWHTSPK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010749">
        <property type="entry name" value="DUF1323"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07037">
        <property type="entry name" value="DUF1323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13411" checksum="12993A849E792A12" modified="2005-12-06" version="1">MFKERMTPDELARLTGYSRQTINKWVRKEGWTTSPKPGVQGGKARLVHVNEQVREYIRNAERPEGQGEAPALSGDAPLEVLLVTLAKEMTPVEQKQFTSLLLREGIIGLLQRLGIRDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DJ8</accession>
    <name>Q32DJ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fimbrial-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DJ8"/>
    <dbReference type="STRING" id="300267.SDY_2538"/>
    <dbReference type="EnsemblBacteria" id="ABB62607">
        <property type="protein sequence ID" value="ABB62607"/>
        <property type="gene ID" value="SDY_2538"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2538"/>
    <dbReference type="HOGENOM" id="CLU_088965_3_0_6"/>
    <dbReference type="OMA" id="QDCNFNT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220918" evidence="1">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="162" mass="16953" checksum="C164DE5AFA4D67FE" modified="2005-12-06" version="1">MSKFVKTAIAATMVMGAFASTSTIAAGNNGTARFYGTIEDSPCSIVPDDHKLEVDMGDIGSGILKNNGTSTPKAFQIHLQDCVFDTQTTMTTTFTGNASSTNSGNYYTIYNTDTGAAFNNVSLAIGDAQGTSYKSGTGINQTIVKDTATNKGKAKQTLDFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DL9</accession>
    <name>Q32DL9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dedA</name>
        <name evidence="4" type="ordered locus">SDY_2516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000364333.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404077.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DL9"/>
    <dbReference type="STRING" id="300267.SDY_2516"/>
    <dbReference type="EnsemblBacteria" id="ABB62586">
        <property type="protein sequence ID" value="ABB62586"/>
        <property type="gene ID" value="SDY_2516"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2516"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3031"/>
    <dbReference type="HOGENOM" id="CLU_044208_6_1_6"/>
    <dbReference type="OMA" id="PWYGIGR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="24630" checksum="643AB7F1D0B5E12C" modified="2005-12-06" version="1">MDLIYFLIDFILHIDVHLAELVAEYGVWVYAILFLILFCETGLVVTPFLPGDSLLFVAGALASLETNDLNVHMMVVLMLIAAIVGDAVNYTIGRLFGEKLFSNPNSKIFRRSYLDKTHQFYEKHGGKTIILARFVPIVRTFAPFVAGMGHMSYRHFAAFNVIGALLWVLIFTYAGYFFGTLPFIQSNLKLMIVGIIFVSILPGVFEFIRHKRAAARAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DM7</accession>
    <name>Q32DM7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histidine-binding periplasmic protein of high-affinity histidine transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisJ</name>
        <name evidence="8" type="ordered locus">SDY_2508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000737625.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404069.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DM7"/>
    <dbReference type="STRING" id="300267.SDY_2508"/>
    <dbReference type="EnsemblBacteria" id="ABB62578">
        <property type="protein sequence ID" value="ABB62578"/>
        <property type="gene ID" value="SDY_2508"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2508"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3023"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_0_6"/>
    <dbReference type="OMA" id="FSEEPYG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005768">
        <property type="entry name" value="Lys_Arg_Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01096">
        <property type="entry name" value="3A0103s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220924" evidence="6">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="7">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="260" mass="28509" checksum="43D24BCABCCFA647" modified="2005-12-06" version="1">MKKLVLSLSLVLAFSSATAAFAAIPQNIRIGTDPTYAPFESKNSQGELVGFDIDLAKELCKRINTQCTFVENPLDALIPSLKAKKIDAIMSSLSITEKRQQEIAFTDKLYAADSRLVVAKNSDIQPTVESLKGKRVGVLQGTTQETFGNEYWAPKGIEIVSYQGQDNIYSDLTAGRIDAAFQDEVAASEGFLKQPVGKDYKFGGPSVKDEKLFGVGTGMGLRKEDNELREALNKAFAEMRADGTYEKLAKKYFDFDVYGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E25</accession>
    <name>AROA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="1">EPSP synthase</shortName>
            <shortName evidence="1">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroA</name>
        <name type="ordered locus">SDY_2353</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPSP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000445217.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403921.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E25"/>
    <dbReference type="SMR" id="Q32E25"/>
    <dbReference type="STRING" id="300267.SDY_2353"/>
    <dbReference type="EnsemblBacteria" id="ABB62430">
        <property type="protein sequence ID" value="ABB62430"/>
        <property type="gene ID" value="SDY_2353"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2353"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2838"/>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_6"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000012479" description="3-phosphoshikimate 1-carboxyvinyltransferase">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="1">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <sequence length="424" mass="45785" checksum="01DB67B8C74F702B" modified="2005-12-06" version="1">MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALAALGVSYTLSADRTRCEIIGNGGSLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E49</accession>
    <name>Q32E49_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aspC</name>
        <name evidence="6" type="ordered locus">SDY_2329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000462687.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403897.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E49"/>
    <dbReference type="SMR" id="Q32E49"/>
    <dbReference type="STRING" id="300267.SDY_2329"/>
    <dbReference type="EnsemblBacteria" id="ABB62406">
        <property type="protein sequence ID" value="ABB62406"/>
        <property type="gene ID" value="SDY_2329"/>
    </dbReference>
    <dbReference type="GeneID" id="66670796"/>
    <dbReference type="KEGG" id="sdy:SDY_2329"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2812"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_6"/>
    <dbReference type="OMA" id="VGACTIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="PTHR11879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="28"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="396" mass="43573" checksum="9F0437E76DD4FC0F" modified="2005-12-06" version="1">MFENITAAPADPILGLADLFRADERPGKINLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGTGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSNPPAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E61</accession>
    <name>Q32E61_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiphosphoryl transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fruB</name>
        <name evidence="10" type="ordered locus">SDY_2317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000487223.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403885.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E61"/>
    <dbReference type="STRING" id="300267.SDY_2317"/>
    <dbReference type="EnsemblBacteria" id="ABB62394">
        <property type="protein sequence ID" value="ABB62394"/>
        <property type="gene ID" value="SDY_2317"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2317"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2795"/>
    <dbReference type="HOGENOM" id="CLU_046384_0_0_6"/>
    <dbReference type="OMA" id="QGIEWGE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="HPr" evidence="9">
        <location>
            <begin position="285"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="376" mass="39633" checksum="CE7ADD4E70C28E22" modified="2005-12-06" version="1">MFQLSVQDIHPGEKAGDKEEAIRLVAAALVQAGNVAEGYVNGMLAREQQTSTFLGNGIAIPHGTTDTRDQVLKTGVQVFQFPEGVTWGDGQVAYVAIGIAASSDEHLGLLRQLTHVLSDDSVAEQLKSATTAEELRALLMGEKQSEQLKLDNEMLTLDIVASDLLTLQALNAARLKEAGAVDATFVTKAINEQPLNLGQGIWLSDSAEGNLRSAIAVSRAANAFDVDGETAAMLVSVAMNDDQPIAVLKRLADLLLDNKADRLLKADAATLLALLTSDDAPTDDVLSAEFVVRNEHGLHARPGTMLVNTIKQFNSDITVTNLDGTGKPANGRSLMKVVALGVKKGHRLRFTAQGADAEQALKAIGDAIAAGLGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EA3</accession>
    <name>Q32EA3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yegX</name>
        <name evidence="4" type="ordered locus">SDY_2275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EA3"/>
    <dbReference type="STRING" id="300267.SDY_2275"/>
    <dbReference type="EnsemblBacteria" id="ABB62352">
        <property type="protein sequence ID" value="ABB62352"/>
        <property type="gene ID" value="SDY_2275"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2275"/>
    <dbReference type="HOGENOM" id="CLU_044973_3_1_6"/>
    <dbReference type="OMA" id="FINTIYE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="165" mass="19188" checksum="244DBAB30FDB14CC" modified="2005-12-06" version="1">MDPYFSRNWQLSRENGLLRGAYHYFSPSVAAPVQARLFLQTVDFSQGDFPAVLDVEERGKLSAKELRKRVSQWLKMVEKSTGKKPIIYSGAVFYHTNLAGHFNEYPWWVAHYYQRRPDNDDMAWRFWQHSDRGQVDGINGPVDFNVFNGTVEELHAFVDGIKETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ED8</accession>
    <name>Q32ED8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">dacD</name>
        <name evidence="16" type="ordered locus">SDY_2233</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403808.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ED8"/>
    <dbReference type="STRING" id="300267.SDY_2233"/>
    <dbReference type="EnsemblBacteria" id="ABB62317">
        <property type="protein sequence ID" value="ABB62317"/>
        <property type="gene ID" value="SDY_2233"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2233"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2699"/>
    <dbReference type="HOGENOM" id="CLU_027070_8_1_6"/>
    <dbReference type="OMA" id="IQAGSWV"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBP5_C" evidence="15">
        <location>
            <begin position="272"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB62317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="378" mass="42256" checksum="A010E4C6DBA4700C" modified="2005-12-06" version="1">MFVFNLSSGFAAENIPFSPQPPEIHAGSWVLMDYTTGQILTSGNEHQQRNPASLTKLMTGYVVDRAIDSHRITPDDIVTVGRDAWAKDNPVFVGSSLMFLKEGDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEKLHLKDTHFETVHGLDAPGQHSSAYDLAVLSRAIIHGEPEFYHMYSEKSLTWNGITQQNRNGLLWDKTMNIDGLKTGHTSGAGFNLMASAVDGQRRLIAVVMGADSAKGREEEARKLLRWGQQNFTTVQILHRGKKVGTERIWYGDKENIALGTEQEFWMVLPKAEIPHIKAKYTLDGKELTAPISAHQRVGEIELYDRDKQVAHWPLVTLESVGEGSMFSRLSDYFHHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EG1</accession>
    <name>Q32EG1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-antigen polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfc</name>
        <name evidence="2" type="ordered locus">SDY_2209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000220864.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403785.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EG1"/>
    <dbReference type="EnsemblBacteria" id="ABB62294">
        <property type="protein sequence ID" value="ABB62294"/>
        <property type="gene ID" value="SDY_2209"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2209"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2672"/>
    <dbReference type="HOGENOM" id="CLU_707633_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="380" mass="43702" checksum="2DB5EEE49C965F04" modified="2005-12-06" version="1">MTYFTGFILILFAIIIKRLTPSQSKKNIVLIANAFWGILLVGYAFNEQYFVPLSATTLFFILAFLFFFSMTYILIARSGRVVFSFGTGFIESKYIYWFAGMINIISICFGIILLYNNHFSLKVMREGILDGSISGFGLGISLPLSFCCMYLARHENKKNYFYCFTLLSFLLAVLSTSKIFLILFLVYIVGINSYVSKKKLLIYGVFVFGLFALSSIILGKFSSDPEGKIISAIFDTLRVYLFSGLAAFNLYVEKNATLPENLLLYPFKEVWGTTKDIPKTDILPWINIGVWDTNVYTAFAPWYQSLGLYAAIIIGILLGFYYGIWFSFRQNLAVGFYQTFLCFPLLMLFFQEHYLLSWKMHFIYFLCAILLAMRKALEYE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EI1</accession>
    <name>MDTD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Putative multidrug resistance protein MdtD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mdtD</name>
        <name type="ordered locus">SDY_2188</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Could be the product of a pseudogene. This sequence is much shorter than orthologs.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403765.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EI1"/>
    <dbReference type="SMR" id="Q32EI1"/>
    <dbReference type="STRING" id="300267.SDY_2188"/>
    <dbReference type="EnsemblBacteria" id="ABB62274">
        <property type="protein sequence ID" value="ABB62274"/>
        <property type="gene ID" value="SDY_2188"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2188"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2646"/>
    <dbReference type="HOGENOM" id="CLU_796686_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="uncertain"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000268600" description="Putative multidrug resistance protein MdtD">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="348" mass="38004" checksum="15A76F07F3494641" modified="2005-12-06" version="1">MEYASWHWIFLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGLSPLAIAGLVAVGVVALVLYLLHARNNNRALFSLKLFRTRTFSLGLAGGFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNHFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFGSQHVSVDSGTTKPSLCTPGLAWRLSSPFRRSSLPECQTIRIKTWLFRVEKGARNEVLAARYYRQTVSGDFRHLHCLADQYALGGAYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EM4</accession>
    <name>Q32EM4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vancomycin sensitivity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sanA</name>
        <name evidence="2" type="ordered locus">SDY_2143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000920064.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403722.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EM4"/>
    <dbReference type="STRING" id="300267.SDY_2143"/>
    <dbReference type="EnsemblBacteria" id="ABB62231">
        <property type="protein sequence ID" value="ABB62231"/>
        <property type="gene ID" value="SDY_2143"/>
    </dbReference>
    <dbReference type="GeneID" id="66673960"/>
    <dbReference type="KEGG" id="sdy:SDY_2143"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2590"/>
    <dbReference type="HOGENOM" id="CLU_051474_0_2_6"/>
    <dbReference type="OMA" id="YDEPDAM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023604">
        <property type="entry name" value="Uncharacterised_SanA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005011">
        <property type="entry name" value="SanA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="48"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="239" mass="27287" checksum="574EF9B02249547C" modified="2005-12-06" version="1">MLKRVFLSLLVLIGLLLLTVLGLDRWMSWKTAPYIYDELQDLPYRQVGVVLGTAKYYRTGVINQYYRYRIQGAINAYNSGKVNYLLLSGDNALQSYNEPMTMRKDLIAAGVDPSDIVLDYAGFRTLDSIVRTRKVFDTNDFIIITQRFHCERALFIALHMGIQAQCYAVPSPKDMLSVRIREFAARFGALADLYIFKREPRFLGPLVPIPAMHQVPEDAQGYPAVTPEQLLELQKKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EV7</accession>
    <name>Q32EV7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yceG</name>
        <name evidence="7" type="synonym">mltG</name>
        <name evidence="8" type="ordered locus">SDY_2053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000756849.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403639.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EV7"/>
    <dbReference type="STRING" id="300267.SDY_2053"/>
    <dbReference type="EnsemblBacteria" id="ABB62148">
        <property type="protein sequence ID" value="ABB62148"/>
        <property type="gene ID" value="SDY_2053"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2053"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2468"/>
    <dbReference type="HOGENOM" id="CLU_025574_0_2_6"/>
    <dbReference type="OMA" id="IAMPGKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="340" mass="38254" checksum="5A83A0D08323FA41" modified="2005-12-06" version="1">MKKVLLIILLLLVVLGIAAGVGVWKVRYLADSKLLIKEETIFTLKPGTGHLALGEQLYADKIINRPRVFQWLLRIEPDLSHFKAGTYRFTPQMTVREMLKLLESGKEAQFPLRLVEGMRLSDYLKQLREAPYIKHTLSDDKYATVAQALELENPEWIEGWFWPDTWMYTANTTDVALLKRAHKKMVKAVDSAWEGRADGLPYKDKNQLVTMASIIEKETAVASERDQVASVFINRLRIGMRLQTDPTVIYGMGERYNGKLSRADLETPTAYNTYTITGLPPGAIATPGADSLKAAAHPAKTPYLYFVADGKGGHTFNTNLASHNKSVQDYLKVLKEKNAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EV8</accession>
    <name>KTHY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmk</name>
        <name type="ordered locus">SDY_2052</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001257000.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403638.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EV8"/>
    <dbReference type="SMR" id="Q32EV8"/>
    <dbReference type="STRING" id="300267.SDY_2052"/>
    <dbReference type="EnsemblBacteria" id="ABB62147">
        <property type="protein sequence ID" value="ABB62147"/>
        <property type="gene ID" value="SDY_2052"/>
    </dbReference>
    <dbReference type="GeneID" id="66670636"/>
    <dbReference type="KEGG" id="sdy:SDY_2052"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2467"/>
    <dbReference type="HOGENOM" id="CLU_049131_0_1_6"/>
    <dbReference type="OMA" id="VMTREPG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000023282" description="Thymidylate kinase">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <sequence length="213" mass="23783" checksum="16BC0A725AAFCB72" modified="2005-12-06" version="1">MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSVGDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQDKSIHTIDATQPLEAVMDAIRTTVTHWVKELDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F87</accession>
    <name>Q32F87_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ynhC</name>
        <name evidence="1" type="ordered locus">SDY_1912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000907952.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403509.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F87"/>
    <dbReference type="STRING" id="300267.SDY_1912"/>
    <dbReference type="EnsemblBacteria" id="ABB62018">
        <property type="protein sequence ID" value="ABB62018"/>
        <property type="gene ID" value="SDY_1912"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1912"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2302"/>
    <dbReference type="HOGENOM" id="CLU_026231_5_0_6"/>
    <dbReference type="OMA" id="PNCESHQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="423" mass="46979" checksum="E4A71B7E4CEC742C" modified="2005-12-06" version="1">MAGLPNSSNALQQWHHLFEAEGAKRSPQAQQHLQQLLCTGLPTRKHENWKYTPLEGLTNSQFVSIAGEISPQQRDVLALTLDAVRLVFVDGRYVPALSDVTEGSGYEVSINDDRQGLPDAIQAEVFLHLTESLAQSVTHIAVKRGQRPAKPLLLMHITQGVTGEEVNTAHYRHHLDLAEGAEATVIEHFVSLNDARHFTGARFTINVAANAHLQHIKLAFENPVSHHFAHNDLLLAENATAFSHSFLLGGTVLRHNTSTQLNGENSTLRINSLAMPVKNEVCDTRTWLEHNKGFCNSRQLHKTIVSDKGRAVFNCLINVAQHAIKTDGQMTNNNLLMGKLAEVDTKPQLEIYADDVKCSHGATEGRIDDEQMFYLRSRGINQQDAQQMIIYAFAAELTEALRDEELKQQVLARIGQRLPGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FB7</accession>
    <name>Q32FB7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutaredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ydhD</name>
        <name evidence="11" type="ordered locus">SDY_1880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000108172.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403479.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FB7"/>
    <dbReference type="SMR" id="Q32FB7"/>
    <dbReference type="STRING" id="300267.SDY_1880"/>
    <dbReference type="EnsemblBacteria" id="ABB61988">
        <property type="protein sequence ID" value="ABB61988"/>
        <property type="gene ID" value="SDY_1880"/>
    </dbReference>
    <dbReference type="GeneID" id="67415642"/>
    <dbReference type="KEGG" id="sdy:SDY_1880"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2261"/>
    <dbReference type="HOGENOM" id="CLU_026126_2_1_6"/>
    <dbReference type="OMA" id="KGTKLMP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014434">
        <property type="entry name" value="Monothiol_GRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="PTHR10293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005894">
        <property type="entry name" value="Monothiol_GRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00365">
        <property type="entry name" value="TIGR00365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="10">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glutathione binding" evidence="8">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB61988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="115" mass="12879" checksum="254B540430632645" modified="2005-12-06" version="1">MSTTIEKIQRQIAENPILLYMKGSPKLPSCGFSAQAVQALAACGERFAYVDILQNPDIRAELPKYANWPTFPQLWVDGELVGGCDIVIEMYQRGELQQLIKETAAKYKSEEPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FC9</accession>
    <name>Q32FC9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403467.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FC9"/>
    <dbReference type="STRING" id="300267.SDY_1867"/>
    <dbReference type="EnsemblBacteria" id="ABB61976">
        <property type="protein sequence ID" value="ABB61976"/>
        <property type="gene ID" value="SDY_1867"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1867"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2246"/>
    <dbReference type="HOGENOM" id="CLU_018816_15_2_6"/>
    <dbReference type="OMA" id="YTWVKLA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="4">
        <location>
            <begin position="31"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="58"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="96"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="299" mass="33021" checksum="1DC9CD36D3D43C7F" modified="2005-12-06" version="1">MRLPCSGNTDCVVTMSIKTIKYFSTIIVAVVAVLAGWWLWNYYMQSPWTRDGKIRVEQVSITPQVSGRIVRLNIKDNQLVNAGDLLLTIDKTPFQIAKLNAQAQLAKAQSDLAKANNEANRRRHLSQNFISAEELDTANLNVKAMQASVDAAQATLKQAQWQLAQTEIRAPVSGWVTNLTTRIGDYADTGKPLFALVDSNSFYVIGYFEETKLRHIREGAPAQITLYSDNKTLQGHVSSIGRAIYDQSVESDSSLIPDVKPNVPWVRLAQRVPVRFALDKVPGDVTLVSGTTCSISVGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FE4</accession>
    <name>RSXC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ion-translocating oxidoreductase complex subunit C</fullName>
            <ecNumber evidence="1">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Rsx electron transport complex subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsxC</name>
        <name type="ordered locus">SDY_1852</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000915691.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403452.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FE4"/>
    <dbReference type="STRING" id="300267.SDY_1852"/>
    <dbReference type="EnsemblBacteria" id="ABB61961">
        <property type="protein sequence ID" value="ABB61961"/>
        <property type="gene ID" value="SDY_1852"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1852"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2231"/>
    <dbReference type="HOGENOM" id="CLU_010808_2_1_6"/>
    <dbReference type="OMA" id="QQLYWYS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00461">
        <property type="entry name" value="RsxC_RnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01945">
        <property type="entry name" value="rnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000013613" description="Ion-translocating oxidoreductase complex subunit C">
        <location>
            <begin position="1"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 1" evidence="1">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 2" evidence="1">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="772" mass="83761" checksum="178C78A18443F25C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FZ1</accession>
    <name>Q32FZ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FZ1"/>
    <dbReference type="STRING" id="300267.SDY_1640"/>
    <dbReference type="EnsemblBacteria" id="ABB61764">
        <property type="protein sequence ID" value="ABB61764"/>
        <property type="gene ID" value="SDY_1640"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1640"/>
    <dbReference type="HOGENOM" id="CLU_242772_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041047">
        <property type="entry name" value="LPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040561">
        <property type="entry name" value="LPD38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041131">
        <property type="entry name" value="MuF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18796">
        <property type="entry name" value="LPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18857">
        <property type="entry name" value="LPD38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18819">
        <property type="entry name" value="MuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LPD1" evidence="2">
        <location>
            <begin position="157"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="MuF_C" evidence="3">
        <location>
            <begin position="546"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="LPD38" evidence="4">
        <location>
            <begin position="1271"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1588" mass="176583" checksum="97C659433DFB219B" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G47</accession>
    <name>YNFB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0482 protein YnfB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ynfB</name>
        <name type="ordered locus">SDY_1576</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0482 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000705200.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403199.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G47"/>
    <dbReference type="STRING" id="300267.SDY_1576"/>
    <dbReference type="EnsemblBacteria" id="ABB61708">
        <property type="protein sequence ID" value="ABB61708"/>
        <property type="gene ID" value="SDY_1576"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1576"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1892"/>
    <dbReference type="HOGENOM" id="CLU_167574_0_0_6"/>
    <dbReference type="OMA" id="EPNTERC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01581">
        <property type="entry name" value="UPF0482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009700">
        <property type="entry name" value="DUF1283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06932">
        <property type="entry name" value="DUF1283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000300230" description="UPF0482 protein YnfB">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01581"/>
        </source>
    </evidence>
    <sequence length="113" mass="12971" checksum="9BFD879073BEC918" modified="2005-12-06" version="1" precursor="true">MKITLSKRIGLLAFLLPCALALSTTVHAETNKLVIESGDSAQSRQHAAMEKEQWNDTRNLRRKVNKRTEKEWDKADAAFDNRDKCEQSANINAYWEPNTLRCLDRRTGRVITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G57</accession>
    <name>Q32G57_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAGC-like transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlc</name>
        <name evidence="2" type="ordered locus">SDY_1562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000225286.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403189.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G57"/>
    <dbReference type="STRING" id="300267.SDY_1562"/>
    <dbReference type="EnsemblBacteria" id="ABB61698">
        <property type="protein sequence ID" value="ABB61698"/>
        <property type="gene ID" value="SDY_1562"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1562"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1872"/>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_6"/>
    <dbReference type="OMA" id="FFIRHQQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="406" mass="44253" checksum="0A29E9CF483E295D" modified="2005-12-06" version="1">MVAENQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLVQELEIKEAGNRGRPAVGLVVETEAWHYLSLRISRGEIFLALRDLSSNLVVEESQELALKDDSPLLDRIISNIDQFFIRHQKKLERLTSIAITLPGIIDTENGIVHRMPFYEDVKEMPLGEALEQHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSILELAQLRLNQSMSSMLHGQPLTVDSLCQAALRGDLLAKDIITGVGAHVGRILAIMVNLFNPQKILIGSPLSKAADILFPVISDSIRQQALPAYSQHISVESTQFSNQGTMAGAALVKDAMYNGSLLIRLLQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G79</accession>
    <name>NADE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="1">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadE</name>
        <name type="ordered locus">SDY_1540</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000175020.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403167.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G79"/>
    <dbReference type="SMR" id="Q32G79"/>
    <dbReference type="STRING" id="300267.SDY_1540"/>
    <dbReference type="EnsemblBacteria" id="ABB61676">
        <property type="protein sequence ID" value="ABB61676"/>
        <property type="gene ID" value="SDY_1540"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1540"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1845"/>
    <dbReference type="HOGENOM" id="CLU_059327_3_0_6"/>
    <dbReference type="OMA" id="MAFLYDY"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000077608" description="NH(3)-dependent NAD(+) synthetase">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <sequence length="275" mass="30681" checksum="269376826D1F4583" modified="2005-12-06" version="1">MTLQQQIIKALGAKPQINAEEEIRRSIDFLKSYLQTYPFIKSLVLGISGGQDSTLAGKLCQMAINELRQETGNESLQFIAVRLPYGVQADEQDCQDAIAFIQPDRVLTVNIKGAVLASEQALREAGIELSDFVRGNEKARERMKAQYSIAGMTSGVVVGTDHAAEAITGFFTKYGDGGTDINPLYRLNKRQGKQLLAALGCPEHLYKKAPTADLEDDRPSLPDEVVLGVTYDNIDDYLEGKNVPEQVARTIENWYLKTEHKRRPPITVFDDFWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G94</accession>
    <name>Q32G94_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ydjZ</name>
        <name evidence="3" type="ordered locus">SDY_1524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000977144.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403152.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G94"/>
    <dbReference type="STRING" id="300267.SDY_1524"/>
    <dbReference type="EnsemblBacteria" id="ABB61661">
        <property type="protein sequence ID" value="ABB61661"/>
        <property type="gene ID" value="SDY_1524"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1524"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1824"/>
    <dbReference type="HOGENOM" id="CLU_038944_8_0_6"/>
    <dbReference type="OMA" id="WVERHGF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="235" mass="26049" checksum="8487B5D8A611CF27" modified="2005-12-06" version="1">MMKMQSRKIWYYRITLIILLFAMLLAWALLPGVHEFINRSVAAFAAVDQQGIERFIQSYGALAAVVSFLLMILQAIAAPLPAFLITSANASLFGALWGGLLSWTSSMAGAALCFFIARVMGREVVEKLTGKTVLDSMDGFFTRYGNHTILVCRLLPFVPFDPISYAAGLTSIRFRSFFIATGLGQLPATIVYSWAGSMLTGGTFWFVTGLFILFALTVVIFMAKKIWLERQKRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GF7</accession>
    <name>Q32GF7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron transport protein, periplasmic-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sitA</name>
        <name evidence="5" type="ordered locus">SDY_1457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000555620.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403089.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GF7"/>
    <dbReference type="STRING" id="300267.SDY_1457"/>
    <dbReference type="EnsemblBacteria" id="ABB61598">
        <property type="protein sequence ID" value="ABB61598"/>
        <property type="gene ID" value="SDY_1457"/>
    </dbReference>
    <dbReference type="GeneID" id="58462205"/>
    <dbReference type="KEGG" id="sdy:SDY_1457"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1735"/>
    <dbReference type="HOGENOM" id="CLU_016838_1_1_6"/>
    <dbReference type="OMA" id="HHVFGYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220971" evidence="4">
        <location>
            <begin position="27"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="304" mass="33472" checksum="DFAB20D03958CEDA" modified="2005-12-06" version="1">MHSIKKVTMLLGCLALTCSIAFQASATEKFKVITTFTIIADMAKNVAGDAAEVSSITKPGAEIHEYQPTPGDIKRAQGAQLILANGMNLELWFQRFYQHLNGVPEVIVSSGVTPVGITEGPYEGKPNPHAWMSPDNALIYVDNIRDALIKYDPANAQTYQRNADTYKAKITQTLAPLRKQITELPENQRWMVTSEGAFSYLARDLGLKELYLWPINADQQGTPQQVRKVVDIVKKNHIPAVFSESTISDKPARQVARETGAHYGGVLYVDSLSTENGPVPTYIDLLKVTTSTLVQGIKAGKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GS3</accession>
    <name>Q32GS3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YrdC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yciO</name>
        <name evidence="2" type="ordered locus">SDY_1335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402973.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GS3"/>
    <dbReference type="STRING" id="300267.SDY_1335"/>
    <dbReference type="EnsemblBacteria" id="ABB61482">
        <property type="protein sequence ID" value="ABB61482"/>
        <property type="gene ID" value="SDY_1335"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1335"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1584"/>
    <dbReference type="HOGENOM" id="CLU_031397_3_0_6"/>
    <dbReference type="OMA" id="MLYPTDT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="218" mass="24401" checksum="FBD6E446F6771A4A" modified="2005-12-06" version="1">MGTAAEHHSEGIMSQFFYIHPDNPQQRLINQAVEIVRKGGVIVYPTDSGYALGCKIEDKNAVERICRIRQLPDGHNFTLMCRDLSELSTYSFVDNVAFRLMKNNTPGNYTFILKGTKEVPRRLLQEKRKTIGMRVPSNPIAQALLEALGEPMLSTSLMLPGSEFTESDPEEIKDRLEKQVDLIIHGGYLGQKPTTVIDLTDDTPVVVREGVGDVKPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H04</accession>
    <name>Q32H04_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ychF</name>
        <name evidence="7" type="ordered locus">SDY_1252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000505866.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402892.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H04"/>
    <dbReference type="SMR" id="Q32H04"/>
    <dbReference type="STRING" id="300267.SDY_1252"/>
    <dbReference type="EnsemblBacteria" id="ABB61401">
        <property type="protein sequence ID" value="ABB61401"/>
        <property type="gene ID" value="SDY_1252"/>
    </dbReference>
    <dbReference type="GeneID" id="66674977"/>
    <dbReference type="KEGG" id="sdy:SDY_1252"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1489"/>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_6"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="278"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="363" mass="39667" checksum="9C2DAFFAC7586F53" modified="2005-12-06" version="1">MGFKCGIVGLPNVGKSTLFNALTKAGIEAANFPFCTIEPNTGVVPMPDPRLDQLAEIVKPQRTLPTTMEFVDIAGLVKGASKGEGLGNQFLTNIRETEAIGHVVRCFENDNIIHVSGKVNPADDIEVINTELALADLDTCERAIHRVQKKAKGGDKDAKAELAVLEKCLPQLENAGMLRALDLSAEEKAAIRYLSFLTLKPTMYIANVNEDGFENNPYLDQVREIAAKEGSVVVPVCAAVEADIAELDDEERDEFMQELGLEEPGLNRVIRAGYKLLNLQTYFTAGVKEVRAWTIPVGATAPQAAGKIHTDFEKGFIRAQTISFEDFITYKGEQGAKEAGKMRAEGKDYIVKDGDVMNFLFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H20</accession>
    <name>Q32H20_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ymgE</name>
        <name evidence="8" type="ordered locus">SDY_1234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000511315.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402876.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H20"/>
    <dbReference type="STRING" id="300267.SDY_1234"/>
    <dbReference type="EnsemblBacteria" id="ABB61385">
        <property type="protein sequence ID" value="ABB61385"/>
        <property type="gene ID" value="SDY_1234"/>
    </dbReference>
    <dbReference type="GeneID" id="67417487"/>
    <dbReference type="KEGG" id="sdy:SDY_1234"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1464"/>
    <dbReference type="HOGENOM" id="CLU_160040_2_3_6"/>
    <dbReference type="OMA" id="RMGMFAN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="8703" checksum="BBED915EEF2582BF" modified="2005-12-06" version="1">MGIIAWIIFGLIAGIIAKLIMPGRDGGGFFLTCILGIVGAVVGGWLATMFGIGGSISGFNLHSFLVAVVGAILVLGVFRLLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HB2</accession>
    <name>Q32HB2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KHG/KDPG aldolase</fullName>
            <ecNumber evidence="7">4.1.2.14</ecNumber>
            <ecNumber evidence="6">4.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">eda</name>
        <name evidence="13" type="ordered locus">SDY_1136</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:30687"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:62213"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:35639"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:71685"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism; 2-dehydro-3-deoxy-D-gluconate degradation; D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; glyoxylate and dicarboxylate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="7"/>
    <dbReference type="EC" id="4.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000800516.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402784.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HB2"/>
    <dbReference type="STRING" id="300267.SDY_1136"/>
    <dbReference type="EnsemblBacteria" id="ABB61293">
        <property type="protein sequence ID" value="ABB61293"/>
        <property type="gene ID" value="SDY_1136"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1136"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1338"/>
    <dbReference type="HOGENOM" id="CLU_077795_1_1_6"/>
    <dbReference type="OMA" id="FFPAEYC"/>
    <dbReference type="UniPathway" id="UPA00227"/>
    <dbReference type="UniPathway" id="UPA00856">
        <property type="reaction ID" value="UER00829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB61293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="213" mass="22327" checksum="CC8D43A625A0D0B7" modified="2005-12-06" version="1">MKNWKTSAESILTTGPVVPVIVVKKLEHAVPMAKALVAGGVRVLEVTLRTECAVDAIRAIAKEVPEAIVGAGTVLNPQQLAEVTEAGAQFAISPGLTEPLLKAATEGTIPLIPGISTVSELMLGMDYGLKEFKFFPAEANGGVKALQAIAGPFSQVRFCPTGGISPANYRDYLALKSVRCIGGSWLVPADALEAGDYDRITKLAREAVEGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HD6</accession>
    <name>Q32HD6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yecH</name>
        <name evidence="1" type="ordered locus">SDY_1112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000377227.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402760.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HD6"/>
    <dbReference type="STRING" id="300267.SDY_1112"/>
    <dbReference type="EnsemblBacteria" id="ABB61269">
        <property type="protein sequence ID" value="ABB61269"/>
        <property type="gene ID" value="SDY_1112"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1112"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1306"/>
    <dbReference type="HOGENOM" id="CLU_172471_0_0_6"/>
    <dbReference type="OMA" id="TCSAENM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019620">
        <property type="entry name" value="Metal-bd_prot_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10678">
        <property type="entry name" value="DUF2492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03853">
        <property type="entry name" value="matur_matur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="79" mass="8618" checksum="4A0973C7E0439EAA" modified="2005-12-06" version="1">MDSIHGHEVLNMMIESGEQYTHASLEAAIKARFGEQARFHTCSAEGMTAGELVAFLAAKGKFTPSEDGFSTDQSKICRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HG6</accession>
    <name>Q32HG6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402730.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HG6"/>
    <dbReference type="STRING" id="300267.SDY_1076"/>
    <dbReference type="EnsemblBacteria" id="ABB61239">
        <property type="protein sequence ID" value="ABB61239"/>
        <property type="gene ID" value="SDY_1076"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1076"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1264"/>
    <dbReference type="HOGENOM" id="CLU_2720128_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="7667" checksum="CD71C7D2305EA2E2" modified="2005-12-06" version="1">MKSGVTTDWKETADGVYKATYTAYTKGSGLTAKLLMQNWNEDLHTAGFIIDANPQSAKIATLSASNNGVLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HH6</accession>
    <name>Q32HH6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402720.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HH6"/>
    <dbReference type="STRING" id="300267.SDY_1064"/>
    <dbReference type="EnsemblBacteria" id="ABB61229">
        <property type="protein sequence ID" value="ABB61229"/>
        <property type="gene ID" value="SDY_1064"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1064"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1250"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="OMA" id="NTLANWH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11153" checksum="6EA1023738FA6D99" modified="2005-12-06" version="1">MSRKTQRYSKEFKAEAVRMVLENQLSISEGASRLSLPEGPLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEACLERDILKKATAYFAQESLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HQ9</accession>
    <name>Q32HQ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HQ9"/>
    <dbReference type="STRING" id="300267.SDY_0977"/>
    <dbReference type="EnsemblBacteria" id="ABB61146">
        <property type="protein sequence ID" value="ABB61146"/>
        <property type="gene ID" value="SDY_0977"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0977"/>
    <dbReference type="HOGENOM" id="CLU_139675_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="191" mass="21712" checksum="F1201BFCF694F423" modified="2005-12-06" version="1">MTYTIQYVQDVDIVRVSLPGRASEAITDFKGYYWYGFMEYIENINACDDVFSEYCLDDENISVQPEWINTPGISDLDTGIDLSGISFIQSETNQALGLKYAPVDGDGYCLLRAILVLKQHDYSWALGSHKTQKEVYEEFIKIVDKQTIEALVDAAFYDLREDVKTLFGVDLQSDNKVQGVGSPMSWSFLFF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HV1</accession>
    <name>MATP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macrodomain Ter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">matP</name>
        <name type="ordered locus">SDY_0929</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MatP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000877161.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402595.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HV1"/>
    <dbReference type="SMR" id="Q32HV1"/>
    <dbReference type="STRING" id="300267.SDY_0929"/>
    <dbReference type="EnsemblBacteria" id="ABB61104">
        <property type="protein sequence ID" value="ABB61104"/>
        <property type="gene ID" value="SDY_0929"/>
    </dbReference>
    <dbReference type="GeneID" id="58461146"/>
    <dbReference type="KEGG" id="sdy:SDY_0929"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1076"/>
    <dbReference type="HOGENOM" id="CLU_142157_0_0_6"/>
    <dbReference type="OMA" id="QEAHWKW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01073">
        <property type="entry name" value="MatP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009390">
        <property type="entry name" value="MatP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035375">
        <property type="entry name" value="MatP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035087">
        <property type="entry name" value="MatP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038339">
        <property type="entry name" value="MatP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06303">
        <property type="entry name" value="MatP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17414">
        <property type="entry name" value="MatP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000064636" description="Macrodomain Ter protein">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01073"/>
        </source>
    </evidence>
    <sequence length="150" mass="17693" checksum="B2E971E41317CF31" modified="2005-12-06" version="1">MKYQQLENLESGWKWKYLVKKHREGELITRYIEASAAQEAVDVLLSLENEPVLVNGWIDKHMNPELVNRMKQTIRARRKRHFNAEHQHTRKKSIDLEFIVWQRLAGLAQRRGKTLSETIVQLIEDAENKEKYANKMSSLKQDLQALLGKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HV8</accession>
    <name>RLMKL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase K/L</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">23S rRNA m2G2445 methyltransferase</fullName>
                <ecNumber evidence="1">2.1.1.173</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">rRNA (guanine-N(2)-)-methyltransferase RlmL</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">23S rRNA m7G2069 methyltransferase</fullName>
                <ecNumber evidence="1">2.1.1.264</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">rRNA (guanine-N(7)-)-methyltransferase RlmK</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmL</name>
        <name type="ordered locus">SDY_0921</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42740"/>
            <dbReference type="Rhea" id="RHEA-COMP:10215"/>
            <dbReference type="Rhea" id="RHEA-COMP:10216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.173"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43772"/>
            <dbReference type="Rhea" id="RHEA-COMP:10688"/>
            <dbReference type="Rhea" id="RHEA-COMP:10689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.264"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RlmKL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.173" evidence="1"/>
    <dbReference type="EC" id="2.1.1.264" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001086562.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402588.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HV8"/>
    <dbReference type="SMR" id="Q32HV8"/>
    <dbReference type="STRING" id="300267.SDY_0921"/>
    <dbReference type="EnsemblBacteria" id="ABB61097">
        <property type="protein sequence ID" value="ABB61097"/>
        <property type="gene ID" value="SDY_0921"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0921"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1067"/>
    <dbReference type="HOGENOM" id="CLU_014042_2_0_6"/>
    <dbReference type="OMA" id="WIRGYEA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052915">
        <property type="term" value="F:23S rRNA (guanine(2445)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01858">
        <property type="entry name" value="23SrRNA_methyltr_KL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017244">
        <property type="entry name" value="23SrRNA_methyltr_KL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037618">
        <property type="entry name" value="RNA_Mtase_bacteria_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000366838" description="Ribosomal RNA large subunit methyltransferase K/L">
        <location>
            <begin position="1"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="THUMP" evidence="1">
        <location>
            <begin position="43"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01858"/>
        </source>
    </evidence>
    <sequence length="702" mass="78843" checksum="1A16B4AF00C5393A" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HW1</accession>
    <name>PYRD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="1">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DHOdehase</fullName>
            <shortName evidence="1">DHOD</shortName>
            <shortName evidence="1">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrD</name>
        <name type="ordered locus">SDY_0918</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020284.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402585.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HW1"/>
    <dbReference type="SMR" id="Q32HW1"/>
    <dbReference type="STRING" id="300267.SDY_0918"/>
    <dbReference type="EnsemblBacteria" id="ABB61094">
        <property type="protein sequence ID" value="ABB61094"/>
        <property type="gene ID" value="SDY_0918"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0918"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1064"/>
    <dbReference type="HOGENOM" id="CLU_013640_2_0_6"/>
    <dbReference type="OMA" id="ERIKMGA"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000024231" description="Dihydroorotate dehydrogenase (quinone)">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
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        </location>
        <ligand>
            <name>substrate</name>
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            <position position="177"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <begin position="318"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <sequence length="336" mass="36795" checksum="EEA37B7585E56AF7" modified="2005-12-06" version="1">MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNFGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEDELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I03</accession>
    <name>Q32I03_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Periplasmic nitrate reductase, electron transfer subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Diheme cytochrome c NapB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">napB</name>
        <name evidence="14" type="ordered locus">SDY_0875</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Electron transfer subunit of the periplasmic nitrate reductase complex NapAB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 2 heme C groups per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the NapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I03"/>
    <dbReference type="STRING" id="300267.SDY_0875"/>
    <dbReference type="EnsemblBacteria" id="ABB61052">
        <property type="protein sequence ID" value="ABB61052"/>
        <property type="gene ID" value="SDY_0875"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0875"/>
    <dbReference type="HOGENOM" id="CLU_103367_3_0_6"/>
    <dbReference type="OMA" id="PIVPNEF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005591">
        <property type="entry name" value="NapB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38604">
        <property type="entry name" value="PTHR38604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03892">
        <property type="entry name" value="NapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006105">
        <property type="entry name" value="NapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0574">Periplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221007" description="Periplasmic nitrate reductase, electron transfer subunit" evidence="13">
        <location>
            <begin position="35"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB61052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="156" mass="17118" checksum="79541593402D11BD" modified="2005-12-06" version="1">MEFGSEIMKSHDLKKVLCQWTAMLALVVSGAVWAANGVDFSQSPEVSGTQEGAIRMPKEQDRMPLNYVNQPPMIPHSVEGYQVTTNTNRCLQCHGVESYRTTGAPRISPTHFMDSDGKVGAEVAPRRYFCLQCHVPQADTAPIVGNTFTPSKGYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IB3</accession>
    <name>Q32IB3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">moeA</name>
        <name evidence="9" type="ordered locus">SDY_0760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000397374.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402433.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IB3"/>
    <dbReference type="STRING" id="300267.SDY_0760"/>
    <dbReference type="EnsemblBacteria" id="ABB60944">
        <property type="protein sequence ID" value="ABB60944"/>
        <property type="gene ID" value="SDY_0760"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0760"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.874"/>
    <dbReference type="HOGENOM" id="CLU_010186_7_0_6"/>
    <dbReference type="OMA" id="MTGAMVP"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="181"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="411" mass="44125" checksum="3B97AD3C9812C7CA" modified="2005-12-06" version="1">MEFTTGLMSLDTALNEMLSRVTPLTAQETLPLVQCFGRILASDVVSPLDVPGFDNSAMDGYAVRLADIASGQPLPVASKSFAGQPYHGEWPAGTCIRIMTGTPVPEGCEAVVMQEQTEQTDNGVRFTAEVRSGQNIRRRGEDISAGAVVFPAGTRLTTAELPVIASLGIAEVPVIRKVRVVLFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLEQLGCEVINLGIIRDDPHALRAAFIEADSQADVVISSGGVSVGEADYTKTILEELGEIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSATLTFYQLVQPLLAKLSGNTASGLPARQRVRTASRLKKTPGRLDFQRGVLQRNADGELEVTTTGHQGSHIFSSFSLGNCFIVLERDRGNVEVGEWVEVEPFNALFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IS8</accession>
    <name>Q32IS8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000228032.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402268.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IS8"/>
    <dbReference type="STRING" id="300267.SDY_0579"/>
    <dbReference type="EnsemblBacteria" id="ABB60779">
        <property type="protein sequence ID" value="ABB60779"/>
        <property type="gene ID" value="SDY_0579"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0579"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.679"/>
    <dbReference type="HOGENOM" id="CLU_155134_1_0_6"/>
    <dbReference type="OMA" id="CHIRAFG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010774">
        <property type="entry name" value="YbcO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07102">
        <property type="entry name" value="DUF1364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="96" mass="10812" checksum="065BA51851BAAC41" modified="2005-12-06" version="1">MVDLRKAARGQMCTVRIPGYCNHDPETSVLAHYRLAGTCGTATKPHDMQAAIACSSCHDLIDGRVKTSDYTKEELRLMHAEGVFRTQEIWRKEGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IY1</accession>
    <name>Q32IY1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding component of ferric enterobactin transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fepC</name>
        <name evidence="5" type="ordered locus">SDY_0519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000140647.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402215.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IY1"/>
    <dbReference type="SMR" id="Q32IY1"/>
    <dbReference type="STRING" id="300267.SDY_0519"/>
    <dbReference type="EnsemblBacteria" id="ABB60726">
        <property type="protein sequence ID" value="ABB60726"/>
        <property type="gene ID" value="SDY_0519"/>
    </dbReference>
    <dbReference type="GeneID" id="66671137"/>
    <dbReference type="KEGG" id="sdy:SDY_0519"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.612"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_6"/>
    <dbReference type="OMA" id="FHIDAEI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="271" mass="29784" checksum="B734924A31F06CE1" modified="2005-12-06" version="1">MTESVARLRGEQLTLGYGKYTVAENLTVEIPDGHFTAIIGPNGCGKSTLLRTLSRLMTPAHGHVWLDGEHIQHYASKEVARRIGLLAQNATTPGDITVQELVARGRYPHQPLFTRWRKEDEEAVTKAMQATGITHLADQSVDTLSGGQRQRAWIAMVLAQETAIMLLDEPTTWLDISHQIDLLELLSELNREKGYTLAAVLHDLNQACRYASHLIALREGKIVAQGAPKEIVTAELIERIYGLRCMIIDDPVAGTPLVVPLGRTAPSTANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J41</accession>
    <name>Q32J41_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybaJ</name>
        <name evidence="1" type="ordered locus">SDY_0458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000344800.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402155.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J41"/>
    <dbReference type="SMR" id="Q32J41"/>
    <dbReference type="STRING" id="300267.SDY_0458"/>
    <dbReference type="EnsemblBacteria" id="ABB60666">
        <property type="protein sequence ID" value="ABB60666"/>
        <property type="gene ID" value="SDY_0458"/>
    </dbReference>
    <dbReference type="GeneID" id="66671237"/>
    <dbReference type="KEGG" id="sdy:SDY_0458"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.541"/>
    <dbReference type="HOGENOM" id="CLU_164850_0_0_6"/>
    <dbReference type="OMA" id="CERVEKY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019693">
        <property type="entry name" value="Biofilm_formation_reg_YbaJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10757">
        <property type="entry name" value="YbaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="124" mass="14557" checksum="5F410DFFBD29F270" modified="2005-12-06" version="1">MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYLDDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J42</accession>
    <name>Q32J42_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acrB</name>
        <name evidence="7" type="ordered locus">SDY_0457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cell inner membrane</location>
            <topology evidence="2 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001132497.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402154.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J42"/>
    <dbReference type="SMR" id="Q32J42"/>
    <dbReference type="STRING" id="300267.SDY_0457"/>
    <dbReference type="EnsemblBacteria" id="ABB60665">
        <property type="protein sequence ID" value="ABB60665"/>
        <property type="gene ID" value="SDY_0457"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0457"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.540"/>
    <dbReference type="HOGENOM" id="CLU_002755_1_1_6"/>
    <dbReference type="OMA" id="LMYMSSS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="875"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="975"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1007"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1049" mass="113530" checksum="AF7F8BFD5C071245" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J86</accession>
    <name>Q32J86_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein QmcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybbK</name>
        <name evidence="4" type="ordered locus">SDY_0410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000904507.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402110.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J86"/>
    <dbReference type="STRING" id="300267.SDY_0410"/>
    <dbReference type="EnsemblBacteria" id="ABB60621">
        <property type="protein sequence ID" value="ABB60621"/>
        <property type="gene ID" value="SDY_0410"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0410"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.487"/>
    <dbReference type="HOGENOM" id="CLU_024949_2_2_6"/>
    <dbReference type="OMA" id="TQIRAEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="Band_7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STOMATIN"/>
    </dbReference>
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        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="18"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="305" mass="33771" checksum="0A6A8BFBCC8FBCC3" modified="2005-12-06" version="1">MLIFIPILIFVALVIVGAGVKIVPQGYQWTVERFGRYTKTLQPGLSLVVPFMDRIGRKINMMEQVLDIPSQEVISKDNANVTIDAVCFIQVIDAPRAAYEVSNLELAIINLTMTNIRTVLGSMELDEMLSQRDSINSRLLRIVDEATNPWGIKVTRIEIRDVRPPAELISSMNVQMKAERTKRAYILEAEGIRQAEILKAEGEKQSQILKAEGERQSAFLQAEARERSAEAEARATKMVSEAIASGDIQAVNYFVAQKYTEALQQIGSSSNSKVVMMPLEASSLMGSIAGIAELVKDSANKRTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J92</accession>
    <name>Q32J92_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybbA</name>
        <name evidence="5" type="ordered locus">SDY_0405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001110582.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402104.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J92"/>
    <dbReference type="STRING" id="300267.SDY_0405"/>
    <dbReference type="EnsemblBacteria" id="ABB60616">
        <property type="protein sequence ID" value="ABB60616"/>
        <property type="gene ID" value="SDY_0405"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0405"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.481"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="YSLFPWR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="228" mass="24519" checksum="8CF01B8A840E7C24" modified="2005-12-06" version="1">MPAENIVEVHHLKKSVGQGEHELSILTGVELVVKRGETIALVGESGSGNSTLLAILAGLDDGSSGEVSLVGQPLHNMDEEARAKLRAKHVGFVFQSFMLIPTLNALENVELPALLRGESSAESRNGAKALLEQLGLGKRLDHLPAQLSGGEQQRVALARAFNGRPDVLFADEPTGNLDRQTGDKIADLLFSLNREHGTTLIMVTHDLQLAARCDRCLRLVNGQLQEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JD9</accession>
    <name>Q32JD9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of aro operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroM</name>
        <name evidence="1" type="ordered locus">SDY_0353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001276400.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402057.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JD9"/>
    <dbReference type="STRING" id="300267.SDY_0353"/>
    <dbReference type="EnsemblBacteria" id="ABB60568">
        <property type="protein sequence ID" value="ABB60568"/>
        <property type="gene ID" value="SDY_0353"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0353"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.414"/>
    <dbReference type="HOGENOM" id="CLU_077346_0_0_6"/>
    <dbReference type="OMA" id="VMHCMGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010843">
        <property type="entry name" value="Uncharacterised_AroM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07302">
        <property type="entry name" value="AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="225" mass="24974" checksum="EE00D345261768AD" modified="2005-12-06" version="1">MSASLAILTIGIVPMQEVLPLLTEYIDEDNISHHSLLGKLSREEVMAEYAPEAGEDTILTLLNDNHLAHVSRRKVERDLQGVVEVLDNQGYDVIILMSTANISSMTARNTIFLEPSRILPPLVFSIVEDHQVGVIVPVEELLTVQAQKWQILQKPPVFSLGNPIHDSEQKIIDAGKELLAKGADVIMLDCLGFNQRHRDLLQKQLDVPVLLSNVLIARLAAELQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JM8</accession>
    <name>Q32JM8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sfmC</name>
        <name evidence="4" type="ordered locus">SDY_0256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401968.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JM8"/>
    <dbReference type="STRING" id="300267.SDY_0256"/>
    <dbReference type="EnsemblBacteria" id="ABB60479">
        <property type="protein sequence ID" value="ABB60479"/>
        <property type="gene ID" value="SDY_0256"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0256"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.289"/>
    <dbReference type="HOGENOM" id="CLU_070768_3_3_6"/>
    <dbReference type="OMA" id="KSWGRTI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001829">
        <property type="entry name" value="Pili_assmbl_chaperone_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016147">
        <property type="entry name" value="Pili_assmbl_chaperone_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00345">
        <property type="entry name" value="PapD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00969">
        <property type="entry name" value="CHAPERONPILI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="SSF49354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220894" evidence="2">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_N" evidence="3">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="121" mass="13553" checksum="06AEB958B44CC6C8" modified="2005-12-06" version="1">MMTKIKLLMLIIFYLIISASAHAAGGIALGATRIIYPADAKQTAVWIRNSHTNERFLVNSWIENSSGVKEKSFIITPPLFVSEPKSENTLRIIYTGPPLAADRESLFWMNVKTIPVMLPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JP5</accession>
    <name>Q32JP5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401951.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JP5"/>
    <dbReference type="EnsemblBacteria" id="ABB60462">
        <property type="protein sequence ID" value="ABB60462"/>
        <property type="gene ID" value="SDY_0238"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0238"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.266"/>
    <dbReference type="HOGENOM" id="CLU_2496184_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221142" evidence="1">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9903" checksum="661D45A19FF1517C" modified="2005-12-06" version="1">MRMRKITIILLLTFSCTKGLAFDISMSKECSGVDELEFIDCVKNSFIMSTITLKKAEANIKEKIQKWNSDEDEAIRKEAVISLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K93</accession>
    <name>Q32K93_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Aconitate hydratase B</fullName>
            <ecNumber evidence="5 16">4.2.1.3</ecNumber>
            <ecNumber evidence="6 16">4.2.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">2-methylisocitrate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">acnB</name>
        <name evidence="22" type="ordered locus">SDY_0025</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="5 16"/>
    <dbReference type="EC" id="4.2.1.99" evidence="6 16"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378536.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401753.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K93"/>
    <dbReference type="STRING" id="300267.SDY_0025"/>
    <dbReference type="EnsemblBacteria" id="ABB60265">
        <property type="protein sequence ID" value="ABB60265"/>
        <property type="gene ID" value="SDY_0025"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0025"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="9 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
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        <location>
            <begin position="4"/>
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        </location>
    </feature>
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            <end position="382"/>
        </location>
    </feature>
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        <location>
            <begin position="472"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="18">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="18">
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        </location>
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        <location>
            <position position="191"/>
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        <location>
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        <ligand>
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        </ligand>
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            <position position="796"/>
        </location>
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        </source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00012926"/>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="865" mass="93527" checksum="316B8C7289BBFFC3" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-05-15" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A4SH25</accession>
    <name>A4SH25_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">InsA</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_PA02</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
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        <name>pSD197_spA</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Sd197</strain>
            <plasmid evidence="9">Plasmid pSD197_spA</plasmid>
        </source>
    </reference>
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        <text evidence="1">Absolutely required for transposition of IS1.</text>
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        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="ABO87496"/>
        <property type="gene ID" value="SDY_PA02"/>
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    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="OMA" id="KGTAGHQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD197_spA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABO87496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="9883" checksum="559580896663F5E4" modified="2007-05-15" version="1">MASVSINCPSCSATDGGVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVSLNTILRHLKNSGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q326R6</accession>
    <name>Q326R6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MxiN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mxiN</name>
        <name evidence="1" type="ordered locus">SDY_P179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378997.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406180.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326R6"/>
    <dbReference type="EnsemblBacteria" id="ABB64692">
        <property type="protein sequence ID" value="ABB64692"/>
        <property type="gene ID" value="SDY_P179"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P179"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5734"/>
    <dbReference type="HOGENOM" id="CLU_1199123_0_0_6"/>
    <dbReference type="OMA" id="DYICEWK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="231" mass="26845" checksum="1A790BDD62D68D31" modified="2005-12-06" version="1">MKVCNMQKGTLPVSRHHAYDGVVIKRMEKELCKTIKDRDTESKKKAICVIKDATKKAESLRIDAVCDGYQIGIQTAFEHIVDYICEWKLKQNENRRNIEDYITSLLSENLHDERIISTLLEQWLSSLRNTVTELKVVLPKCNSALRKKLELDLYKYRSDVKIIFKYSEGNNYIFCSGNQVVEFSPQDVISGVKIELAEKLTKNDKKYFEELAHKKLRQIAEDLLKENPVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q326V6</accession>
    <name>Q326V6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS1294 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000198558.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406140.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326V6"/>
    <dbReference type="EnsemblBacteria" id="ABB64652">
        <property type="protein sequence ID" value="ABB64652"/>
        <property type="gene ID" value="SDY_P139"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P139"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5696"/>
    <dbReference type="HOGENOM" id="CLU_038153_0_0_6"/>
    <dbReference type="OMA" id="TQTNKVR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007069">
        <property type="entry name" value="Transposase_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026889">
        <property type="entry name" value="Zn_Tnp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04986">
        <property type="entry name" value="Y2_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14319">
        <property type="entry name" value="Zn_Tnp_IS91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS91" evidence="1">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="402" mass="45874" checksum="5B80ED8DF1776A11" modified="2005-12-06" version="1">MTRSGGDFQPRPLKRLFTTNQCWTSFLDAGGLRDIEVEAVTKMLACGTRILGVKEYNCDKPECPHVRYVTNSCGSRACPSCGKKATDLWIATQLNRLPDCDWVHLVFTLPDTLWPVFESNRWLLNDVCRLAVENLLYAARKRGQEPGIFCAIHTYGRRLNCHPHVHVSVTCGCLNKHGQWKKLSFLKDAMRSRWMWNMRQLLLKAWSEGLAMPESLSHITTESQWRSLVLKAGGKYWHVYMSKKTAGGRNTARYLGRYLKKPPIAASRLAHYNGGASLSFRYLDHKTGETATETLTQRELVARLKQHIPEKFFKMVRYFGFLANRVCGEKLPQVYRALGMDKPAPVAKVCYAQMVKQFLSRDPFECVLCGGRMVYRRAIAGLNVEGLKKNARDISLLRYMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Z2</accession>
    <name>Q326Z2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS4 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011379024.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406104.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Z2"/>
    <dbReference type="EnsemblBacteria" id="ABB64616">
        <property type="protein sequence ID" value="ABB64616"/>
        <property type="gene ID" value="SDY_P103"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P103"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5657"/>
    <dbReference type="HOGENOM" id="CLU_028400_1_1_6"/>
    <dbReference type="OMA" id="WHINEHR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024473">
        <property type="entry name" value="Transposases_IS4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13006">
        <property type="entry name" value="Nterm_IS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nterm_IS4" evidence="2">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="448" mass="51066" checksum="370118B78CEF38CF" modified="2005-12-06" version="1">MFPDSFMHIGQALDLVSRYDSLRNPLTSLGDYLAPELISRCLAESGTVTLRKRRLPLEMMVWCIVGMVLERKEPLHQIVNRLDIMLPGNRPFVAPSAVIQARQRLGSEAVRRVFTKTAQLWHNATPHPHWCGLTLLAIDGVFWRTPDTPENDAAFPRQTHAGNPALYPQVKMVCQMELTSHLLTAAAFGTMKNSENELAEQLIEQTGDNTLTLMDKGYYSLGLLNAWSLAGEHRHWMIPLRKGAQYEEIRKLGKGDHLVKLKTSPQARKKWPGLGNEVTARLLTVTRKGKVCHLLTSMTDAMRFPGGEMADLYSHRWEIELGYREIKQTMQLSRLTLRSKKPELVEQELWGVLLAYNLVRYQMIKMAEHLKGYWPNQLSFSESCGMVMRMLMTLQGASPGRIPELMRDLASMGQLVKLPTRRERAFPRVVKERPWKYPTAPKKSQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q327A6</accession>
    <name>Q327A6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406090.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327A6"/>
    <dbReference type="EnsemblBacteria" id="ABB64602">
        <property type="protein sequence ID" value="ABB64602"/>
        <property type="gene ID" value="SDY_P089"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P089"/>
    <dbReference type="HOGENOM" id="CLU_2994226_0_0_6"/>
    <dbReference type="OMA" id="CQTLRTH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="57" mass="6897" checksum="ABA259C24D690CA7" modified="2005-12-06" version="1">MLSGQMFCIPLNNLVGDKINYDKITKITARDWRQYRAPGWQIIHQKRYCQTLRTHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q327E7</accession>
    <name>Q327E7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P009</name>
        <name evidence="4" type="ordered locus">SDY_P048</name>
        <name evidence="5" type="ordered locus">SDY_P143</name>
        <name evidence="6" type="ordered locus">SDY_P152</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 7">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Sd197</strain>
            <plasmid evidence="7">Plasmid pSD1_197</plasmid>
            <plasmid evidence="4">pSD1_197</plasmid>
            <plasmid evidence="4">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406010.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406049.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406144.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406153.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64522">
        <property type="protein sequence ID" value="ABB64522"/>
        <property type="gene ID" value="SDY_P009"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64561">
        <property type="protein sequence ID" value="ABB64561"/>
        <property type="gene ID" value="SDY_P048"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64656">
        <property type="protein sequence ID" value="ABB64656"/>
        <property type="gene ID" value="SDY_P143"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64665">
        <property type="protein sequence ID" value="ABB64665"/>
        <property type="gene ID" value="SDY_P152"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P009"/>
    <dbReference type="KEGG" id="sdy:SDY_P048"/>
    <dbReference type="KEGG" id="sdy:SDY_P143"/>
    <dbReference type="KEGG" id="sdy:SDY_P152"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5539"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="OMA" id="HASACPN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11182" checksum="DFEFA741A3F2D6F8" modified="2005-12-06" version="1">MSRKTQRYSTEFKAEAVKTVPENQLSISEGPSRLSVPEGTLGQWVTAARKGLNTPGSRTVAELESEVMQLRKALNEARLERDILKKATAYFAQESLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q327G0</accession>
    <name>Q327G0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS629 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406036.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327G0"/>
    <dbReference type="EnsemblBacteria" id="ABB64548">
        <property type="protein sequence ID" value="ABB64548"/>
        <property type="gene ID" value="SDY_P035"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P035"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5577"/>
    <dbReference type="HOGENOM" id="CLU_027402_41_1_6"/>
    <dbReference type="OMA" id="WKELMAT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="32"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="207" mass="23249" checksum="CB53AEA5FB626917" modified="2005-12-06" version="1">MGLAGVLRGKKVRTTISRKAVAAGDRVNRQFVAERPDQLWVADFTYVSTWQGFVYVAFIIDVFAGYIVGWRVSSSMETTFVLDALEQALWARRPSGTVHHSDKGSQYVSLAYTQRLKEAGLLASTGSTGDSYDNAMAESINGLYKAEVIHRKSWKNRAEVELATLTWVDWYNNRRLLERLGHTPPAEAEKAYYASIGNDDLAAWVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q327H5</accession>
    <name>Q327H5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ISSfl4 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000622997.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406021.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327H5"/>
    <dbReference type="EnsemblBacteria" id="ABB64533">
        <property type="protein sequence ID" value="ABB64533"/>
        <property type="gene ID" value="SDY_P020"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P020"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5555"/>
    <dbReference type="HOGENOM" id="CLU_128110_1_0_6"/>
    <dbReference type="OMA" id="ARIWLVA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008878">
        <property type="entry name" value="Transposase_IS66_Orf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36455">
        <property type="entry name" value="PTHR36455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05717">
        <property type="entry name" value="TnpB_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="115" mass="13147" checksum="5CD1DE0C250E7D21" modified="2005-12-06" version="1">MISFPAGSRIWLVAGITDMRNGFNGLASKVQNVLKDDPFSGHLFIFRGRRSDQIKVLWADSDGLCLFTRRLERGRFVWPVTRDGKVHLTPAQLSMLLEGIDWKHPKRTERAGIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q327H9</accession>
    <name>Q327H9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS3 orf2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406017.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327H9"/>
    <dbReference type="EnsemblBacteria" id="ABB64529">
        <property type="protein sequence ID" value="ABB64529"/>
        <property type="gene ID" value="SDY_P016"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P016"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5549"/>
    <dbReference type="HOGENOM" id="CLU_3316919_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="39" mass="4404" checksum="50A777D2FE61E30B" modified="2005-12-06" version="1">MPSHHLYLANETQMVGLAPKHTAVQNGMAENFVKTMKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q327I4</accession>
    <name>Q327I4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406012.2">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327I4"/>
    <dbReference type="EnsemblBacteria" id="ABB64524">
        <property type="protein sequence ID" value="ABB64524"/>
        <property type="gene ID" value="SDY_P011"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P011"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5541"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="SSWPNAK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="31957" checksum="3934C99320CC3142" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELNGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPRGYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q327I7</accession>
    <name>Q327I7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406009.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327I7"/>
    <dbReference type="EnsemblBacteria" id="ABB64521">
        <property type="protein sequence ID" value="ABB64521"/>
        <property type="gene ID" value="SDY_P008"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P008"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5538"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_2_6"/>
    <dbReference type="OMA" id="GHEISKY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="2">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="140" mass="16082" checksum="8DFAB7B491F9BF8F" modified="2005-12-06" version="1">MCRVPGVSRSGYYDRVQHEPSDRKQSDERLKLEIKVAHIRTRETYGTRRLQTELADNGIIVGRDRLARLRKELRLHCKQKRKFRATTSSDHNLPVTPNLLNQNFTPTAPNQVWVADSVVQAFRNQPTEGAGRETAAYAVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q327L5</accession>
    <name>DEOC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="1">DERA</shortName>
            <ecNumber evidence="1">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="1">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">deoC</name>
        <name type="ordered locus">SDY_4641</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295412.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405981.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327L5"/>
    <dbReference type="SMR" id="Q327L5"/>
    <dbReference type="STRING" id="300267.SDY_4641"/>
    <dbReference type="EnsemblBacteria" id="ABB64490">
        <property type="protein sequence ID" value="ABB64490"/>
        <property type="gene ID" value="SDY_4641"/>
    </dbReference>
    <dbReference type="GeneID" id="66671731"/>
    <dbReference type="KEGG" id="sdy:SDY_4641"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5502"/>
    <dbReference type="HOGENOM" id="CLU_053595_3_1_6"/>
    <dbReference type="OMA" id="MNACIPP"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00592">
        <property type="entry name" value="DeoC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023649">
        <property type="entry name" value="DeoC_typeII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_1000072613" description="Deoxyribose-phosphate aldolase">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00592"/>
        </source>
    </evidence>
    <sequence length="259" mass="27748" checksum="3D7EA7C83DE4124F" modified="2005-12-06" version="1">MTDLKASSLRALKLMDLTTLNDDDTDEKVIALCHQAKTPVGNTAAICIYPRFIPIARKTLKEQGTPEIRIATVTNFPHGNDDIEIALAETRAAIAYGADEVDVVFPYRALMAGNEQVGFDLVKACKEACAAANVLLKVIIETGELKDEALIRKASEISIKAGADFIKTSTGKVAVNATPESARIMMEVIRDMGVEKTVGFKPAGGVRTAEDAQKYLAIADELFGADWADARHYRFGASSLLASLLKALGHGDGKSASSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q327L6</accession>
    <name>Q327L6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjjI</name>
        <name evidence="1" type="ordered locus">SDY_4640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001143280.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405980.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327L6"/>
    <dbReference type="STRING" id="300267.SDY_4640"/>
    <dbReference type="EnsemblBacteria" id="ABB64489">
        <property type="protein sequence ID" value="ABB64489"/>
        <property type="gene ID" value="SDY_4640"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4640"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5500"/>
    <dbReference type="HOGENOM" id="CLU_046504_1_0_6"/>
    <dbReference type="OMA" id="TIIYHHV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016905">
        <property type="entry name" value="Glycyl_radical_YjjI-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11230">
        <property type="entry name" value="DUF3029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028991">
        <property type="entry name" value="Glycl_rad_HI0521_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04040">
        <property type="entry name" value="glycyl_YjjI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="516" mass="58245" checksum="BD6988A4DF9DD3CE" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q327N3</accession>
    <name>YJJB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable succinate transporter subunit YjjB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjjB</name>
        <name type="ordered locus">SDY_4617</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in succinate export with YjjP. Both proteins are required for export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The transporter is composed of YjjB and YjjP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB64472" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64472.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000538187.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405963.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327N3"/>
    <dbReference type="STRING" id="300267.SDY_4617"/>
    <dbReference type="EnsemblBacteria" id="ABB64472">
        <property type="protein sequence ID" value="ABB64472"/>
        <property type="gene ID" value="SDY_4617"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4617"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5472"/>
    <dbReference type="HOGENOM" id="CLU_117642_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01191">
        <property type="entry name" value="YjjB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020914">
        <property type="entry name" value="YjjB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000293677" description="Probable succinate transporter subunit YjjB">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="157" mass="17063" checksum="9875F2215CB8BABE" modified="2007-07-10" version="2">MGVIEFLLALAQDMILAAIPAVGFAMVFNVPVQALRWCALLGSIGHGSRMILMTSGLNIEWSTFMASMLVGTIGIQWSRWYLAHPKVFTVAAVIPMFPGISAYTAMISAVKISQLGYSEPLMITLLTNFLTASSIVGALSVDLSIPGLWLYRKRPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q327P2</accession>
    <name>Q327P2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjiA</name>
        <name evidence="3" type="ordered locus">SDY_4605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405954.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327P2"/>
    <dbReference type="STRING" id="300267.SDY_4605"/>
    <dbReference type="EnsemblBacteria" id="ABB64463">
        <property type="protein sequence ID" value="ABB64463"/>
        <property type="gene ID" value="SDY_4605"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4605"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5458"/>
    <dbReference type="HOGENOM" id="CLU_017452_0_2_6"/>
    <dbReference type="OMA" id="MWGVLRY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="190"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="284" mass="32022" checksum="2B72640542C95162" modified="2005-12-06" version="1">MIENEFGEVSVDDQLIGDRATQIKTLTNGCICCSRSNELEDALLDLLDNLDKGNIQFDRLVIECTGMADPGPIIQTFFSHEILCQRYLLDGVIALVDAVHADEQMNQFTIAQSQVGYADRILLTKTDVAGEAEKLRERLARINARAPVYTVTHGDIDLGLLFNTNGFMLEENVVSTKPRFHFIADKQNDISSIVVDLDYPVDISEVSRVMENLLLESADKLLRYKGMLWIDGEPNRLLFQGVQRLYSADWDRPWGDEKPHSTMVFIGIQLPEDEIRAAFAGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q327W9</accession>
    <name>Q327W9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjbQ</name>
        <name evidence="2" type="ordered locus">SDY_4511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000270375.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405877.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327W9"/>
    <dbReference type="SMR" id="Q327W9"/>
    <dbReference type="STRING" id="300267.SDY_4511"/>
    <dbReference type="EnsemblBacteria" id="ABB64386">
        <property type="protein sequence ID" value="ABB64386"/>
        <property type="gene ID" value="SDY_4511"/>
    </dbReference>
    <dbReference type="GeneID" id="60902921"/>
    <dbReference type="KEGG" id="sdy:SDY_4511"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5332"/>
    <dbReference type="HOGENOM" id="CLU_096980_0_2_6"/>
    <dbReference type="OMA" id="VRHTSCS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="138" mass="15656" checksum="475F776AFCCAD46D" modified="2005-12-06" version="1">MWYQKTLTLSAKSRGFHLVTDEILNQLADMPRVNIGLLHLLLQHTSASLTLNENCDPTVRHDMERFFLRTVPDNGNYEHDYEGADDMPSHIKSSMLGTSLVLPVHKGRIQTGTWQGIWLGEHRIHGGSRRIIATLQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q327X8</accession>
    <name>Q327X8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Na_H_Exchanger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">yjcE</name>
        <name evidence="12" type="ordered locus">SDY_4502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABB64377">
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        <property type="gene ID" value="SDY_4502"/>
    </dbReference>
    <dbReference type="GeneID" id="66672019"/>
    <dbReference type="KEGG" id="sdy:SDY_4502"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5318"/>
    <dbReference type="HOGENOM" id="CLU_005912_6_3_6"/>
    <dbReference type="OMA" id="TPPFWAS"/>
    <dbReference type="Proteomes" id="UP000002716">
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    <keyword evidence="6 10" id="KW-0915">Sodium</keyword>
    <keyword evidence="9 10" id="KW-0739">Sodium transport</keyword>
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            <end position="25"/>
        </location>
    </feature>
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            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="337"/>
        </location>
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        <location>
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            <end position="385"/>
        </location>
    </feature>
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        <location>
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            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="11">
        <location>
            <begin position="7"/>
            <end position="421"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABB64377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="549" mass="60524" checksum="D654EF3FA4E2B149" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q328A3</accession>
    <name>Q328A3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4476</name>
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        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABB64352">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000002716">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15304" checksum="E71E338A8DE0996B" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q328D8</accession>
    <name>Q328D8_SHIDS</name>
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        <submittedName>
            <fullName evidence="6">Putative transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yjeM</name>
        <name evidence="6" type="ordered locus">SDY_4434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405808.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328D8"/>
    <dbReference type="EnsemblBacteria" id="ABB64317">
        <property type="protein sequence ID" value="ABB64317"/>
        <property type="gene ID" value="SDY_4434"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4434"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5232"/>
    <dbReference type="HOGENOM" id="CLU_020854_2_1_6"/>
    <dbReference type="OMA" id="FMWFASY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="493" mass="53815" checksum="43406C17821C220C" modified="2005-12-06" version="1">MSLIGLILMIFTSVFGFANSPSAYYLMGYSAIPFYIFSALLFFIPFALMMAEMGAAYRKEEGGIYSWMNNSVGPRFAFIGTFMWFSSYIIWMVSTSAKVWVPFSTFLYSSDMTQHWRIAGLEPTQVVGLLAVAWMILVTVVASKGINKIARITAVGGIAVMCLNLVLLLVSITILLLNGGHFAQDINFLASPNPGYQSGLAMLSFVVFAIFAYGGIEAVGGLVDKTENPEKNFAKGIVFAAIVISIGYSLAIFLWGVSTNWQQVLSNGSVNLGNITYVLMKSLGVTLGNALHLSPEASLSLGVWFARITGLSMFLAYTGAFFTLCYSPLKAIIQGTPKALWPEPMTRLNAMGMPSIAMWMQCGLVTVFILLVSFGGGTASAFFNKLTLMANVSMTLPYLFLALAFPFFKARQDLDRPFVIFKTRMSAMIATVVVVLVVTFANVFTIIQPVVEAGDWDSTLWMIGGPVFFSLLAMAIYQNYCSSMANKPELALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q328X8</accession>
    <name>Q328X8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS1294 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000198560.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405618.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328X8"/>
    <dbReference type="EnsemblBacteria" id="ABB64127">
        <property type="protein sequence ID" value="ABB64127"/>
        <property type="gene ID" value="SDY_4225"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4225"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4975"/>
    <dbReference type="HOGENOM" id="CLU_038153_0_0_6"/>
    <dbReference type="OMA" id="ATDQWIA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007069">
        <property type="entry name" value="Transposase_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026889">
        <property type="entry name" value="Zn_Tnp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04986">
        <property type="entry name" value="Y2_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14319">
        <property type="entry name" value="Zn_Tnp_IS91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS91" evidence="1">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="402" mass="45840" checksum="F1CE0B3D86BFA464" modified="2005-12-06" version="1">MTRSGGDFQPRPLKRLFTTNQCWTSFLDAGGLRDIEVEAVTKMLACGTRILGVKEYNCDKPECPHVRYVTNSCGSRACPSCGKKATDLWIATQLNRLPDCDWVHLVFTLPDTLWPVFESNRWLLNDVCRLAVENLLYAARKRGQEPGIFCAIHTYGRRLNCHPHVHVSVTCGGLNKHGQWKKLSFLKDAMRSRWMWNMRQRLLKAWSEGLAMPESLSHITTESQRRSLVLKAGGKYWHVYMSKKTAGGRNTARYLGRYLKKPPIAASRLAHYNGGASLSFRYLDHKTGETATETLTQRELVARLKQHIPEKFFKMVRYFGFLANRVCGEKLPQVYRALGMDKPAPVAKVCYAQMVKQFLSRDPFECVLCGGRMVYRRAIAGLNVEGLKKNARDISLLRYMPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-03" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Z8</accession>
    <name>MDTL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multidrug resistance protein MdtL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdtL</name>
        <name type="ordered locus">SDY_4203</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000085995.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405598.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Z8"/>
    <dbReference type="SMR" id="Q328Z8"/>
    <dbReference type="STRING" id="300267.SDY_4203"/>
    <dbReference type="EnsemblBacteria" id="ABB64107">
        <property type="protein sequence ID" value="ABB64107"/>
        <property type="gene ID" value="SDY_4203"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4203"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4943"/>
    <dbReference type="HOGENOM" id="CLU_001265_47_1_6"/>
    <dbReference type="OMA" id="AGSCYVV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01530">
        <property type="entry name" value="MFS_MdtL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023697">
        <property type="entry name" value="Multidrug-R_MdtL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000282003" description="Multidrug resistance protein MdtL">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="3"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="63"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="152"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="266"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="290"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01530"/>
        </source>
    </evidence>
    <sequence length="391" mass="41506" checksum="CD2EC9E78EF2FFE5" modified="2005-12-06" version="1">MSRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMAIMGIAVLMLSLFILKETRPAAPAASDKSRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAISLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLIMFVAPGRPVAAHEEIHHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q329K1</accession>
    <name>Q329K1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AsmA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yicH</name>
        <name evidence="3" type="ordered locus">SDY_4087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016661.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405495.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329K1"/>
    <dbReference type="STRING" id="300267.SDY_4087"/>
    <dbReference type="EnsemblBacteria" id="ABB64004">
        <property type="protein sequence ID" value="ABB64004"/>
        <property type="gene ID" value="SDY_4087"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4087"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4808"/>
    <dbReference type="HOGENOM" id="CLU_033892_0_0_6"/>
    <dbReference type="OMA" id="IQMSAGS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007844">
        <property type="entry name" value="AsmA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05170">
        <property type="entry name" value="AsmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="569" mass="62187" checksum="95E48A29EF5A99A9" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q329M1</accession>
    <name>RL33_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmG</name>
        <name type="ordered locus">SDY_4066</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001051798.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405475.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329M1"/>
    <dbReference type="SMR" id="Q329M1"/>
    <dbReference type="STRING" id="300267.SDY_4066"/>
    <dbReference type="EnsemblBacteria" id="ABB63984">
        <property type="protein sequence ID" value="ABB63984"/>
        <property type="gene ID" value="SDY_4066"/>
    </dbReference>
    <dbReference type="GeneID" id="8913847"/>
    <dbReference type="KEGG" id="sdy:SDY_4066"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4782"/>
    <dbReference type="HOGENOM" id="CLU_190949_1_1_6"/>
    <dbReference type="OMA" id="GTGFYYT"/>
    <dbReference type="PRO" id="PR:Q329M1"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000004193" description="50S ribosomal protein L33">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <sequence length="55" mass="6372" checksum="31681CC3DAC0C5D6" modified="2005-12-06" version="1">MAKGIREKIKLVSSAGTGHFYTTTKNKRTKPEKLELKKFDPVVRQHVIYKEAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q329N2</accession>
    <name>Q329N2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative beta1,4-galactosyltransferase WaaX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">waaX</name>
        <name evidence="1" type="ordered locus">SDY_4055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001052921.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405464.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329N2"/>
    <dbReference type="STRING" id="300267.SDY_4055"/>
    <dbReference type="CAZy" id="GT25">
        <property type="family name" value="Glycosyltransferase Family 25"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63973">
        <property type="protein sequence ID" value="ABB63973"/>
        <property type="gene ID" value="SDY_4055"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4055"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4771"/>
    <dbReference type="HOGENOM" id="CLU_071269_4_1_6"/>
    <dbReference type="OMA" id="YVINRQA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="257" mass="30626" checksum="882000F13F425EC6" modified="2005-12-06" version="1">MNLPIYIVSLKRDIERRNKINDVFQRLNINFDFFDAIDAKDPQNKEIIDKMRLSGVGAEMTDGEIACTLSHQLIYQDMIDKNIEWAVILEDDVIVNEKFKKFLQYFNLSEKDKLKHNNLYLLGGQKGLHDYPVLGQSLFSKVKISTCTFRRVNFNKNKIRRTCSYLMNKDMAQKLLKLTKDYGTYRADSWKLMHQHHIIKEFYLDEIILHPILNEFNSHLESERLLTSEKKQPRTRLQKRMKFIRSWIKVAFFSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Q1</accession>
    <name>Q329Q1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lldP</name>
        <name evidence="9" type="ordered locus">SDY_4036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016733.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405445.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Q1"/>
    <dbReference type="STRING" id="300267.SDY_4036"/>
    <dbReference type="EnsemblBacteria" id="ABB63954">
        <property type="protein sequence ID" value="ABB63954"/>
        <property type="gene ID" value="SDY_4036"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4036"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4751"/>
    <dbReference type="HOGENOM" id="CLU_021628_0_0_6"/>
    <dbReference type="OMA" id="LFVYKMP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00795">
        <property type="entry name" value="lctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="551" mass="59214" checksum="ADBDCDF1F9F5A347" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q329V7</accession>
    <name>GPPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase</fullName>
            <ecNumber evidence="1">3.6.1.40</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Guanosine pentaphosphate phosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">pppGpp-5'-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gppA</name>
        <name type="ordered locus">SDY_3970</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13073"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:77828"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="EC" id="3.6.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GppA/Ppx family. GppA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.40" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016883.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405389.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329V7"/>
    <dbReference type="SMR" id="Q329V7"/>
    <dbReference type="STRING" id="300267.SDY_3970"/>
    <dbReference type="EnsemblBacteria" id="ABB63898">
        <property type="protein sequence ID" value="ABB63898"/>
        <property type="gene ID" value="SDY_3970"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3970"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4681"/>
    <dbReference type="HOGENOM" id="CLU_025908_4_0_6"/>
    <dbReference type="OMA" id="WQICVGA"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008894">
        <property type="term" value="F:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015974">
        <property type="term" value="P:guanosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01550">
        <property type="entry name" value="GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023709">
        <property type="entry name" value="Guo-5TP_3DP_PyrP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030673">
        <property type="entry name" value="PyroPPase_GppA_Ppx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001267">
        <property type="entry name" value="Pyrophosphatase_GppA_Ppx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000314498" description="Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01550"/>
        </source>
    </evidence>
    <sequence length="494" mass="54945" checksum="D7D30558E7B5B4AA" modified="2005-12-06" version="1">MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPIADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQYMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQESQWQSYVHWPLEVH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q329V8</accession>
    <name>RHLB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent RNA helicase RhlB</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhlB</name>
        <name type="ordered locus">SDY_3969</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. RhlB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000047532.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405388.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329V8"/>
    <dbReference type="SMR" id="Q329V8"/>
    <dbReference type="STRING" id="300267.SDY_3969"/>
    <dbReference type="EnsemblBacteria" id="ABB63897">
        <property type="protein sequence ID" value="ABB63897"/>
        <property type="gene ID" value="SDY_3969"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3969"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4680"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_6"/>
    <dbReference type="OMA" id="EYCTPIQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00661">
        <property type="entry name" value="DEAD_helicase_RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023554">
        <property type="entry name" value="RNA_helicase_ATP-dep_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_1000082872" description="ATP-dependent RNA helicase RhlB">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="40"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="245"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="165"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="421" mass="47172" checksum="3998FD8A4F90A863" modified="2005-12-06" version="1">MSKTHLTEQKFSDFSLHPKVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTSMFHYLLSHPAIADRKVNKPRALIMAPTRELAVQIHADAEPLAEATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMYDLGFIKDIRWLFRRMPPANQRLNMLFSATLSYRVRELAFEQMNNAEYIEVEPEQKTGHRIKEELFYPSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILDEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIETYIGHSIPVSKYNPDALMTDLPKPLRLTRPRTGNGPRRTGAPRNRRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q329W0</accession>
    <name>Q329W0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rho operon leader peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rhoL</name>
        <name evidence="2" type="ordered locus">SDY_3967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295255.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405386.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329W0"/>
    <dbReference type="EnsemblBacteria" id="ABB63895">
        <property type="protein sequence ID" value="ABB63895"/>
        <property type="gene ID" value="SDY_3967"/>
    </dbReference>
    <dbReference type="GeneID" id="66672315"/>
    <dbReference type="KEGG" id="sdy:SDY_3967"/>
    <dbReference type="HOGENOM" id="CLU_3381617_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="33" mass="3750" checksum="8CC2DC4B6C03B589" modified="2005-12-06" version="1">MRSEQISGSSLNPSCRFSSAYSPVTRQRKDMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Y4</accession>
    <name>Q329Y4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uncharacterized lipoprotein YifL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yifL</name>
        <name evidence="8" type="ordered locus">SDY_3937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000799892.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405362.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Y4"/>
    <dbReference type="STRING" id="300267.SDY_3937"/>
    <dbReference type="EnsemblBacteria" id="ABB63871">
        <property type="protein sequence ID" value="ABB63871"/>
        <property type="gene ID" value="SDY_3937"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3937"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4648"/>
    <dbReference type="HOGENOM" id="CLU_200497_0_0_6"/>
    <dbReference type="OMA" id="FRSLAVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032831">
        <property type="entry name" value="LPAM_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13627">
        <property type="entry name" value="LPAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220973" description="Uncharacterized lipoprotein YifL" evidence="7">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7191" checksum="4A52CF490E4F17F9" modified="2005-12-06" version="1">MKNVFKALTVLLTLFSLTGCGLKGPLYFPPAEKNAPPPTKPVETQTQSTVPDKNDRATGDGPSQVNY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AA4</accession>
    <name>HSLU_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent protease ATPase subunit HslU</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein HslU</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Unfoldase HslU</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hslU</name>
        <name type="ordered locus">SDY_3806</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001293350.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405242.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AA4"/>
    <dbReference type="SMR" id="Q32AA4"/>
    <dbReference type="STRING" id="300267.SDY_3806"/>
    <dbReference type="EnsemblBacteria" id="ABB63751">
        <property type="protein sequence ID" value="ABB63751"/>
        <property type="gene ID" value="SDY_3806"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3806"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4496"/>
    <dbReference type="HOGENOM" id="CLU_033123_0_0_6"/>
    <dbReference type="OMA" id="KYGMIKT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00249">
        <property type="entry name" value="HslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="PTHR48102:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_1000012811" description="ATP-dependent protease ATPase subunit HslU">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="60"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00249"/>
        </source>
    </evidence>
    <sequence length="443" mass="49560" checksum="4976663D0A9B9910" modified="2005-12-06" version="1">MSEMTPREIVSELDKHIIGQDNAKRSVAIALRNRWRRMQLNEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPLIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNRYRAEELAEERILDVLIPPAKNNWGQTEQQQEPSAARQAFRKKLREGQLDDKEIEIDLAAAPMGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKARKLKIKDAMKLLIEEEAAKLVNPEELKQDAIDAVEQHGIVFIDEIDKICKRGESSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQIAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNASITVQYKALMATEGVNIEFTDSGIKRIAEAAWQVNESTENIGARRLHTVLERLMEEISYDASDLSGQNITIDADYVSKHLDALVADEDLSRFIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AG6</accession>
    <name>THIE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-phosphate synthase</fullName>
            <shortName evidence="1">TP synthase</shortName>
            <shortName evidence="1">TPS</shortName>
            <ecNumber evidence="1">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="1">TMP pyrophosphorylase</shortName>
            <shortName evidence="1">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiE</name>
        <name type="ordered locus">SDY_3733</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000284604.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405180.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AG6"/>
    <dbReference type="SMR" id="Q32AG6"/>
    <dbReference type="STRING" id="300267.SDY_3733"/>
    <dbReference type="EnsemblBacteria" id="ABB63689">
        <property type="protein sequence ID" value="ABB63689"/>
        <property type="gene ID" value="SDY_3733"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3733"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4425"/>
    <dbReference type="HOGENOM" id="CLU_018272_3_3_6"/>
    <dbReference type="OMA" id="ITAFQFR"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000008171" description="Thiamine-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <sequence length="211" mass="23014" checksum="BAF46224F8539C01" modified="2005-12-06" version="1">MYQPDFPPVPFRLGLYPVVDSVQWIERLLDAGVRTLQLRIKDRRDEEVEADVVAAIALGRRYNARLFINDYWRLAIKHQAYGVHLGQEDLQATDLSAIRAAGLRLGVSTHDDMEIDVALAARPSYIALGHVFPTQTKQMPSAAQGLEQLARHVERLADYPTVAIGGISLPRAPAVIATGVGSIAVVSAITQAADWRLATAQLLEIAGVGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AH2</accession>
    <name>Q32AH2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjaG</name>
        <name evidence="1" type="ordered locus">SDY_3727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000941118.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405174.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AH2"/>
    <dbReference type="STRING" id="300267.SDY_3727"/>
    <dbReference type="EnsemblBacteria" id="ABB63683">
        <property type="protein sequence ID" value="ABB63683"/>
        <property type="gene ID" value="SDY_3727"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3727"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4419"/>
    <dbReference type="HOGENOM" id="CLU_096082_0_0_6"/>
    <dbReference type="OMA" id="FYGVYPA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1590.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007338">
        <property type="entry name" value="DUF416"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023381">
        <property type="entry name" value="YP001051499.1-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04222">
        <property type="entry name" value="DUF416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="196" mass="22652" checksum="B7A365F8DCB05056" modified="2005-12-06" version="1">MLQNPIHLRLERLESWQHVTFMACLCERMYPNYAMFCQQTGFGDGQIYRRILDLIWETLTVKDAKVNFDSQLEKFEETIPSADDFDLYGVYPAIDACVALSELVHSRLSGETLEHAVEVSKTSITTVAMLEMTQAGREMSDEELKENPAVEQEWDIQWEIFRLLAECEERDIELIKGLRADLREAGESNIGIIFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AT2</accession>
    <name>Q32AT2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000558841.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405064.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AT2"/>
    <dbReference type="STRING" id="300267.SDY_3602"/>
    <dbReference type="EnsemblBacteria" id="ABB63573">
        <property type="protein sequence ID" value="ABB63573"/>
        <property type="gene ID" value="SDY_3602"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3602"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4278"/>
    <dbReference type="HOGENOM" id="CLU_088596_0_0_6"/>
    <dbReference type="OMA" id="DHNREWL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014562">
        <property type="entry name" value="UCP030959_TPR_rpt-cont"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030959">
        <property type="entry name" value="UCP030959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="248" mass="28808" checksum="E96F046FCE55D910" modified="2005-12-06" version="1">MHYAVVVMLELLCCIHAYRTGQERYWIFIIFCFPVIGCVAYFVIVMLPETGADRHGHTLLMRLQDKLNPERHLRKLTEELAIAETNQNHYALANELARLERYHEAVPHYQQALSGIFAHEAAMMLSLAQAQFAIQEFAACQQTLEDVMRYNPDFQSADGHLLFARALAAQEKYADAESEFEVLVSYYPGPQARIYYAEMLAKMSRLREANEQYVAVVDTAKRSRPHYRKHHREWIKTANERLKQSVVQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B55</accession>
    <name>RS4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsD</name>
        <name type="ordered locus">SDY_3472</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000135224.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404941.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B55"/>
    <dbReference type="SMR" id="Q32B55"/>
    <dbReference type="STRING" id="300267.SDY_3472"/>
    <dbReference type="EnsemblBacteria" id="ABB63450">
        <property type="protein sequence ID" value="ABB63450"/>
        <property type="gene ID" value="SDY_3472"/>
    </dbReference>
    <dbReference type="GeneID" id="67415337"/>
    <dbReference type="KEGG" id="sdy:SDY_3472"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4125"/>
    <dbReference type="HOGENOM" id="CLU_092403_0_2_6"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000228925" description="30S ribosomal protein S4">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="96"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <sequence length="206" mass="23469" checksum="4015969DF8E582BB" modified="2005-12-06" version="1">MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKVRRIYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHKAIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGTFKRKPERSDLSADINEHLIVELYSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B56</accession>
    <name>RPOA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="1">RNAP subunit alpha</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoA</name>
        <name type="ordered locus">SDY_3471</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001162097.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404940.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B56"/>
    <dbReference type="SMR" id="Q32B56"/>
    <dbReference type="STRING" id="300267.SDY_3471"/>
    <dbReference type="EnsemblBacteria" id="ABB63449">
        <property type="protein sequence ID" value="ABB63449"/>
        <property type="gene ID" value="SDY_3471"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3471"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4124"/>
    <dbReference type="HOGENOM" id="CLU_053084_0_0_6"/>
    <dbReference type="OMA" id="LMKFRNF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000225301" description="DNA-directed RNA polymerase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="1">
        <location>
            <begin position="249"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <sequence length="329" mass="36540" checksum="43739AA6A3C9EB52" modified="2005-12-06" version="1">MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASISMRIKVRRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLRDVRQPEVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIADE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BC8</accession>
    <name>RAPZ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase adapter protein RapZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rapZ</name>
        <name type="ordered locus">SDY_3386</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family. RapZ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000243739.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404868.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BC8"/>
    <dbReference type="SMR" id="Q32BC8"/>
    <dbReference type="STRING" id="300267.SDY_3386"/>
    <dbReference type="EnsemblBacteria" id="ABB63377">
        <property type="protein sequence ID" value="ABB63377"/>
        <property type="gene ID" value="SDY_3386"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3386"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4040"/>
    <dbReference type="HOGENOM" id="CLU_059558_1_1_6"/>
    <dbReference type="OMA" id="TVMSFGF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000258998" description="RNase adapter protein RapZ">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA-binding" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <sequence length="284" mass="32519" checksum="661CA36302B26B48" modified="2005-12-06" version="1">MVLMIVSGRSGSGKSVALRALEDMGFYCVDNLPVVLLPDLARTLADREISAAVSIDVRNMPESPEIFEQAMSNLPDAFSPQLLFLDADRNTLIRRYSDTRRLHPLSNKNLSLESAIDKESDLLEPLRSRADLIVDTSEMSVHELAEMLRTRLLGKRERELTMVFESFGFKHGIPIDADYVFDVRFLPNPHWDPKLRPMTGLDKPVAAFLDRHTEVHNFIYQTRSYLELWLPMLETNNRSYLTVAIGCTGGKHRSVYIAEQLADYFRSRGKNVQSRHRTLEKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BK4</accession>
    <name>Q32BK4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-serine dehydratase</fullName>
            <ecNumber evidence="1">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhaP</name>
        <name evidence="3" type="ordered locus">SDY_3304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BK4"/>
    <dbReference type="STRING" id="300267.SDY_3304"/>
    <dbReference type="EnsemblBacteria" id="ABB63301">
        <property type="protein sequence ID" value="ABB63301"/>
        <property type="gene ID" value="SDY_3304"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3304"/>
    <dbReference type="HOGENOM" id="CLU_022305_2_0_6"/>
    <dbReference type="OMA" id="FVEVPCV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="6"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="275" mass="29312" checksum="5F47CC48C8EADE3D" modified="2005-12-06" version="1">MCDYNGLSISGLMMHNELALRSKAEIDAGFARIWQVMHDGIERGMNTEGVLTGPLNVPRRAVALRRQLVSSDNISNDPMNVIDWINMYALAVSEENAAGGRVVTAPTNGACGIIPAVLAYYDKFRRPVNERSIARYFLAAGAIGALYKMNASISGAEVGCQGEIGVACSMAAAGLTELLGGSPAQVCNAAEIAMEHNLGLTCDPVAGQVQIPCIERNAINAVKAVNAARMAMRRTSAPRVSLDKVIETMYETGKDMNDKYRETSRGGLAIKVVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BQ9</accession>
    <name>Q32BQ9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ygiM</name>
        <name evidence="10" type="ordered locus">SDY_3238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001125325.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404737.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BQ9"/>
    <dbReference type="STRING" id="300267.SDY_3238"/>
    <dbReference type="EnsemblBacteria" id="ABB63246">
        <property type="protein sequence ID" value="ABB63246"/>
        <property type="gene ID" value="SDY_3238"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3238"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3867"/>
    <dbReference type="HOGENOM" id="CLU_094106_0_1_6"/>
    <dbReference type="OMA" id="HKGREGW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016476">
        <property type="entry name" value="SH3_dom_pro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006158">
        <property type="entry name" value="UCP006158_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04211">
        <property type="entry name" value="SH3_and_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220991" description="SH3b domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="9">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="95"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="206" mass="23023" checksum="525406F51106FE2B" modified="2005-12-06" version="1">MPKLRLIGLTLLALSATAVSHAEETRYVSDELNTWVRSGPGDHYRLVGTVNAGEEVTLLQTDANTNYAQVKDSSGRTAWIPLKQLSTEPSLCSRVPDLENQVKTLTDKLTNIDNTWNQRTAEMQQKVAQSDSVINGLKEENQKLKNELIVAQKKVDAASVQLDDKQRTIIMQWFMYGGGVLGLGLLLGLVLPHLIPSRKRKDRWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BU8</accession>
    <name>Q32BU8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_3197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BU8"/>
    <dbReference type="EnsemblBacteria" id="ABB63207">
        <property type="protein sequence ID" value="ABB63207"/>
        <property type="gene ID" value="SDY_3197"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3197"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_0_6"/>
    <dbReference type="OMA" id="KSIEIMG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="73" mass="8825" checksum="5078444F14F3C530" modified="2005-12-06" version="1">MVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CB2</accession>
    <name>RLMM_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase M</fullName>
            <ecNumber evidence="1">2.1.1.186</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (cytidine2498-2'-O)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA 2'-O-ribose methyltransferase RlmM</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmM</name>
        <name type="ordered locus">SDY_3024</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42788"/>
            <dbReference type="Rhea" id="RHEA-COMP:10244"/>
            <dbReference type="Rhea" id="RHEA-COMP:10245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.186"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.186" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001045534.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404534.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CB2"/>
    <dbReference type="SMR" id="Q32CB2"/>
    <dbReference type="STRING" id="300267.SDY_3024"/>
    <dbReference type="EnsemblBacteria" id="ABB63043">
        <property type="protein sequence ID" value="ABB63043"/>
        <property type="gene ID" value="SDY_3024"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3024"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3630"/>
    <dbReference type="HOGENOM" id="CLU_043780_0_0_6"/>
    <dbReference type="OMA" id="PVDWMVC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01551">
        <property type="entry name" value="23SrRNA_methyltr_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040739">
        <property type="entry name" value="RlmM_FDX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011224">
        <property type="entry name" value="rRNA_MeTrfase_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18125">
        <property type="entry name" value="RlmM_FDX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028774">
        <property type="entry name" value="UCP028774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000314545" description="Ribosomal RNA large subunit methyltransferase M">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="221"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01551"/>
        </source>
    </evidence>
    <sequence length="366" mass="41891" checksum="9D91D4118A441F82" modified="2005-12-06" version="1">MNKVVLLCRPGFEKECAAEITDKAGQREIFGFARVKENAGYVIYECYQPDDGDKLIRELPFSSLIFARQWFVVGELLQHLPPEDRITPIVGMLQGVVEKGGELRVEVADTNESKELLKFCRKFTVPLRAVLRDAGGLANYETPKRPVVHVFFIAPGCCYTGYSYSNNNSPFYMGIPRLKFPADAPSRSTLKLEEAFHVFIPADEWDERLANGMWAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFKFRPTRSNISWMVCDMVEKPAKVAALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYIQAQLDEHGINAQIQARQLYHDREEVTVHVRRIWAAVGGRRDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CC3</accession>
    <name>Q32CC3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">AMP nucleosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ygdH</name>
        <name evidence="6" type="ordered locus">SDY_3012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + H2O = adenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:20129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.2.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000627984.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404523.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CC3"/>
    <dbReference type="STRING" id="300267.SDY_3012"/>
    <dbReference type="EnsemblBacteria" id="ABB63032">
        <property type="protein sequence ID" value="ABB63032"/>
        <property type="gene ID" value="SDY_3012"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3012"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3616"/>
    <dbReference type="HOGENOM" id="CLU_047550_0_0_6"/>
    <dbReference type="OMA" id="EYKYTKK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008714">
        <property type="term" value="F:AMP nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021826">
        <property type="entry name" value="DUF3412"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037153">
        <property type="entry name" value="YgdH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027820">
        <property type="entry name" value="YgdH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11892">
        <property type="entry name" value="DUF3412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14793">
        <property type="entry name" value="DUF4478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4478" evidence="5">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3412" evidence="4">
        <location>
            <begin position="333"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="454" mass="50958" checksum="AFC463DEE6866B2A" modified="2005-12-06" version="1">MITHISPLGSMDMLSQLEVDMLKRTASSDLYQLFRNCSLAVLNSGSLTDNSKELLSRFENFDINVLRRERGVKLELINPPEEAFVDGRIIRALQANLFAVLRDILFVYGQIHNTVRFPNLNLDNSVHITNLVFSILRNARALHVGEAPNMVVCWGGHSINENEYLYARHVGNQLGLRELNICTGCGPGAMEAPMKGAAVGHAQQRYKDSRFIGMTEPSIIAAEPPNPLVNELIIMPDIEKRLEAFVRIAHGIIIFPGGVGTAEELLYLLGILMNPANKDQVLPLILTGPKESADYFRVLDEFVVHTLGENARCHYRIIIDDAAEVARQMKKSMPLVKENRRDTDDAYSFNWSMRIAPDLQMPFEPSHENMANLKLYPDQPVEVLAADLRRAFSGIVAGNVKEVGIRAIEEFGPYKINGDKEIMRRMDDLLQGFVAQHRMKLPGSAYIPCYEICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CI9</accession>
    <name>Q32CI9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor RpoS</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Sigma S</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sigma-38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpoS</name>
        <name evidence="8" type="ordered locus">SDY_2940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with the RNA polymerase core enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000081545.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404457.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CI9"/>
    <dbReference type="STRING" id="300267.SDY_2940"/>
    <dbReference type="EnsemblBacteria" id="ABB62966">
        <property type="protein sequence ID" value="ABB62966"/>
        <property type="gene ID" value="SDY_2940"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2940"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3532"/>
    <dbReference type="HOGENOM" id="CLU_014793_3_5_6"/>
    <dbReference type="OMA" id="RRVQREF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00959">
        <property type="entry name" value="Sigma70_RpoS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012761">
        <property type="entry name" value="RNA_pol_sigma_RpoS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02394">
        <property type="entry name" value="rpoS_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-1" evidence="5">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="94"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="174"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="262"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="330" mass="38031" checksum="0CBE20E673699BF1" modified="2005-12-06" version="1">MSQNTLKVHDLNEDAEFDENGVEVFDEKALVEEEPSDNDLAEEELLSQGATQRVLDATQLYLGEIGYSPLLTAEEEVYFARRALRGDVASRRRMIESNLRLVVKIARRYGNRGLALLDLIEEGNLGLIRAVEKFDPERGFRFSTYATWWIRQTIERAIMNQTRTIRLPIHIVKELNVYLRTARELSHKLDHEPSAEEIAEQLDKPVDDVSRMLRLNERITSVDTPLGGDSEKALLDILADEKENGPEDTTQDDDMKQSIVKWLFELNAKQREVLARRFGLLGYEAATLEDVGREIDLTRERVRQIQVEGLRRLREILQTQGLNIEALFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CJ3</accession>
    <name>Q32CJ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000562994.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404453.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CJ3"/>
    <dbReference type="STRING" id="300267.SDY_2936"/>
    <dbReference type="EnsemblBacteria" id="ABB62962">
        <property type="protein sequence ID" value="ABB62962"/>
        <property type="gene ID" value="SDY_2936"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2936"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3527"/>
    <dbReference type="HOGENOM" id="CLU_180856_1_1_6"/>
    <dbReference type="OMA" id="EGAWEVY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="78" mass="9233" checksum="DB169FA516D61417" modified="2005-12-06" version="1">MICPRRADEQIEVMAKSPVKDVWTVYQCQHCLYTWRDTEPLRRTSREHYPEAFRMTQKDIDDAPMVPSIPPLLAEGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CQ3</accession>
    <name>Q32CQ3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000209792.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404393.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CQ3"/>
    <dbReference type="STRING" id="300267.SDY_2865"/>
    <dbReference type="EnsemblBacteria" id="ABB62902">
        <property type="protein sequence ID" value="ABB62902"/>
        <property type="gene ID" value="SDY_2865"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2865"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3443"/>
    <dbReference type="HOGENOM" id="CLU_082760_6_2_6"/>
    <dbReference type="OMA" id="NRFGVTC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="143" mass="16175" checksum="5F1F775E7FDF2190" modified="2005-12-06" version="1">MTTLRQPYYELSPAVYNALVQAKTALENSTLDTTLMELIYLRVSQINGCAFCLEMHSKALRKSGVPQHKLDALAGWRVSHHFDERERAALAWAESVTDIARTHAEDEVYQPLLEHFSAAEISDLTFAIGLMNCFNRLAVSMRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CV1</accession>
    <name>Q32CV1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-E factor, negative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rseC</name>
        <name evidence="2" type="ordered locus">SDY_2811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000589063.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404345.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CV1"/>
    <dbReference type="STRING" id="300267.SDY_2811"/>
    <dbReference type="EnsemblBacteria" id="ABB62854">
        <property type="protein sequence ID" value="ABB62854"/>
        <property type="gene ID" value="SDY_2811"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2811"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3386"/>
    <dbReference type="HOGENOM" id="CLU_124911_0_0_6"/>
    <dbReference type="OMA" id="MVKEWAT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026268">
        <property type="entry name" value="RseC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007359">
        <property type="entry name" value="SigmaE_reg_RseC_MucC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35867">
        <property type="entry name" value="PTHR35867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004923">
        <property type="entry name" value="RseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="159" mass="16639" checksum="7D3A95183EE85F62" modified="2005-12-06" version="1">MIKEWATVVSWQNGQALVSCDVKASCSSCASRAGCGSRVLNKLGPQTTHTIIVPCDEPLVPGQKVELGIAEGSLLSSALLVYMSPLVGLFLIASLFQLLFASDVAALCGAVLGGIGGFLIARGYSRKFAARAEWQPIILSVALPPGLVRFETSSEDASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D09</accession>
    <name>Q32D09_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ipaH_6</name>
        <name evidence="13" type="ordered locus">SDY_2753</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LRR-containing bacterial E3 ligase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
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        <property type="protein sequence ID" value="ABB62796"/>
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    <dbReference type="PATRIC" id="fig|300267.13.peg.3320"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030430">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="LRR_dom_sf"/>
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    <dbReference type="InterPro" id="IPR032674">
        <property type="entry name" value="LRR_E3_ligase_N"/>
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    <dbReference type="InterPro" id="IPR029487">
        <property type="entry name" value="NEL_dom"/>
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    <dbReference type="Pfam" id="PF14496">
        <property type="entry name" value="NEL"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TTSSLRR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
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    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
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        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="NEL" evidence="12">
        <location>
            <begin position="324"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB62796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="608" mass="69735" checksum="57D8185D365111E9" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D28</accession>
    <name>Q32D28_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS (Major facilitator superfamily) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hcaT</name>
        <name evidence="7" type="ordered locus">SDY_2732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABB62777">
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        <property type="gene ID" value="SDY_2732"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2732"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="229"/>
        </location>
    </feature>
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            <end position="257"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="371"/>
        </location>
    </feature>
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            <begin position="9"/>
            <end position="356"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="379" mass="41558" checksum="3D7DB3F7F27ACEF8" modified="2005-12-06" version="1">MVLQSTRWLALGYFTYFFSYGIFLPFWSVWLKGIGLTPETIGLLLGAGLVARFLGSLLIAPRVSDPSRLISALRVLALLTLLFAVAFWAGANVAWLMLVMIGFNLFFSPLVPLTDALANTWQKQFPLDYGKVRLWGSVAFVIGSALTGKLVTMFDYRVILVLLTLGVASMLLGFLIRPTIQPQGASRQQESTGWSAWLALVRQNWRFLACVCLLQGAHAAYYGFSAIYWQAAGYSASAVGYLWSLGVVAEVIIFALSNKLFRRCSARDMLLISAICGVVRWGIMGATTALPWLIVVQILHCGTFTVCHLAAMRYISARQGSEVIRLQAVYSAVAMGGSIAIMSVFAGFLYQYLGHGVFWGMALVALPAMFLRPKVVPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D39</accession>
    <name>Q32D39_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2Fe-2S ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fdx</name>
        <name evidence="5" type="ordered locus">SDY_2721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001124474.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404257.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D39"/>
    <dbReference type="STRING" id="300267.SDY_2721"/>
    <dbReference type="EnsemblBacteria" id="ABB62766">
        <property type="protein sequence ID" value="ABB62766"/>
        <property type="gene ID" value="SDY_2721"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2721"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3282"/>
    <dbReference type="HOGENOM" id="CLU_082632_5_2_6"/>
    <dbReference type="OMA" id="SACGGVC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011536">
        <property type="entry name" value="Fdx_isc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02007">
        <property type="entry name" value="fdx_isc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="111" mass="12345" checksum="E2A7741A94A7714B" modified="2005-12-06" version="1">MPKIVILPHQELCPDGAVLEANSGETILDAALRNGIEIEHACEKSCACTTCHCIVREGFDSLPESSEQEDDMLDKAWGLEPESRLSCQARVTDEDLVVEIPRYTINHAREH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-24" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D41</accession>
    <name>PEPB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase B</fullName>
            <ecNumber evidence="1">3.4.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aminopeptidase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pepB</name>
        <name type="ordered locus">SDY_2719</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays an important role in intracellular peptide degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln.</text>
            <dbReference type="EC" id="3.4.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62764" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.11.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62764.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000133554.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404255.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D41"/>
    <dbReference type="SMR" id="Q32D41"/>
    <dbReference type="STRING" id="300267.SDY_2719"/>
    <dbReference type="MEROPS" id="M17.004"/>
    <dbReference type="EnsemblBacteria" id="ABB62764">
        <property type="protein sequence ID" value="ABB62764"/>
        <property type="gene ID" value="SDY_2719"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2719"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3280"/>
    <dbReference type="HOGENOM" id="CLU_013734_7_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00504">
        <property type="entry name" value="Aminopeptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008330">
        <property type="entry name" value="Pept_M17_PepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12404">
        <property type="entry name" value="DUF3663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036388">
        <property type="entry name" value="Ctsl_amnpptdse_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000165844" description="Peptidase B">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="427" mass="46250" checksum="2F9DAD4A0C08D85F" modified="2006-01-24" version="2">MTEAMKITLSTQPADARWGEKATYSINNDGIILHLNGADDLGLIQRAARKIDGLGIKHVQLSGESWDADRCWAFWQGYKAPKGTRKVEWPDLDDAQRQELDNRLMIIDWVRDTINAPAEELGPSQLAQRAVDLISNVAGDRVTYRITKGEDLREQGYMGLHTVGRGSERSPVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQTAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIITYRNGKKVEVMNTDAEGRLVLADGLIDASAQKPELIIDAATLTGAAKTALGNDYHALFSFDDALAGRLLASASQENEPFWRLPLAEFHRSQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYQQGWLHIDCSATYRKAPVEQWSAGATGLGVRTIANLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D42</accession>
    <name>Q32D42_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enhanced serine sensitivity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sseB</name>
        <name evidence="3" type="ordered locus">SDY_2718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D42"/>
    <dbReference type="STRING" id="300267.SDY_2718"/>
    <dbReference type="EnsemblBacteria" id="ABB62763">
        <property type="protein sequence ID" value="ABB62763"/>
        <property type="gene ID" value="SDY_2718"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2718"/>
    <dbReference type="HOGENOM" id="CLU_093817_1_0_6"/>
    <dbReference type="OMA" id="WEKDDGT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027945">
        <property type="entry name" value="SseB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14581">
        <property type="entry name" value="SseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SseB_C" evidence="2">
        <location>
            <begin position="140"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="261" mass="28870" checksum="2DE0EB9472D19930" modified="2005-12-06" version="1">MVLMSETKNELEDLLEKAATEPAHRPAFFRTLLGSTVWVPGTAAQGEAVVEDSALDLQHWEKEDGTSVIPFFTSLEALQQAVEDEQAFVVMPVRTLFEMTLGETLFLNAKLPTGKEFMPREISLLIGEEGNPLSSQEVLEGGESLILSEVAEPPAQMIDSLTTLFKTIKPVKRAFICSIKENEEAQPNLLIGIEADGDIEEIIQAAGSVATDTLPGDEPIDICQVKKGEKGISHFITEHIAPFYERRWGGFLRDFKQNRII</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D47</accession>
    <name>ISPG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="1">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispG</name>
        <name type="ordered locus">SDY_2711</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000556021.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404249.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D47"/>
    <dbReference type="SMR" id="Q32D47"/>
    <dbReference type="STRING" id="300267.SDY_2711"/>
    <dbReference type="EnsemblBacteria" id="ABB62758">
        <property type="protein sequence ID" value="ABB62758"/>
        <property type="gene ID" value="SDY_2711"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2711"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3269"/>
    <dbReference type="HOGENOM" id="CLU_042258_0_0_6"/>
    <dbReference type="OMA" id="PTCGRTQ"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000011526" description="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <sequence length="372" mass="40685" checksum="5058B47BC198D0DA" modified="2005-12-06" version="1">MHSQAPIQRRKSTRIYVGNVPIGDGAPIAVQSMTNTRTTDVEATVNQIKALERVGADIVRVSVPTMDAAEAFKLIKQRVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRMVVDCARDKNIPIRIGVNAGSLEKDLQEKYGEPTPQALLESAMRHVDHLDRLNFDQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARSGAVKSAIGLGLLLSEGIGDTLRVSLAADPVEEIKVGFDILKSLRIRSRGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDVSIIGCVVNGPGEALVSTLGVTGGNKKSGLYEDGVRKDRLDNNDMIDQLEARIRAKASQLDEARRIDVQQVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D96</accession>
    <name>Q32D96_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ypfH</name>
        <name evidence="2" type="ordered locus">SDY_2658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D96"/>
    <dbReference type="STRING" id="300267.SDY_2658"/>
    <dbReference type="ESTHER" id="shifl-YPFH">
        <property type="family name" value="LYsophospholipase_carboxylesterase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62709">
        <property type="protein sequence ID" value="ABB62709"/>
        <property type="gene ID" value="SDY_2658"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2658"/>
    <dbReference type="HOGENOM" id="CLU_1958085_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="128" mass="13632" checksum="F0B77A9A16A300A9" modified="2005-12-06" version="1">MALIGFSQGAIMALESIKAEPGLASRVIAFNGRYASLPETASTATTIHLIHGGEDPVIDLAHAVAAQEALISAGGDVTLDIVEDLGHAIDNRSMQFALDHWRYTIPKHYFDEALSGGKPGDDDVIEMM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DB7</accession>
    <name>HEM6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxygen-dependent coproporphyrinogen-III oxidase</fullName>
            <shortName evidence="1">CPO</shortName>
            <shortName evidence="1">Coprogen oxidase</shortName>
            <shortName evidence="1">Coproporphyrinogenase</shortName>
            <ecNumber evidence="1">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemF</name>
        <name type="ordered locus">SDY_2634</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX</text>
            <dbReference type="Rhea" id="RHEA:18257"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="1.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000801385.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404179.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DB7"/>
    <dbReference type="SMR" id="Q32DB7"/>
    <dbReference type="STRING" id="300267.SDY_2634"/>
    <dbReference type="EnsemblBacteria" id="ABB62688">
        <property type="protein sequence ID" value="ABB62688"/>
        <property type="gene ID" value="SDY_2634"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2634"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3172"/>
    <dbReference type="HOGENOM" id="CLU_026169_0_1_6"/>
    <dbReference type="OMA" id="HDKGTLF"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00333">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="PTHR10755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="SSF102886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0350">Heme biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000019506" description="Oxygen-dependent coproporphyrinogen-III oxidase">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for dimerization" evidence="1">
        <location>
            <begin position="240"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="258"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for dimerization" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00333"/>
        </source>
    </evidence>
    <sequence length="299" mass="34334" checksum="67F815FEFBAD2097" modified="2005-12-06" version="1">MKPDAHQVKQFLLNLQDTICQQLTAVDGAEFVEDSWQRESGGGGRSRVLRNGGVFEQAGVNFSHVHGEAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGAEPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGEDVYPRYKKWCDDYFYLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTDAYLPIVERRKAMAYAERERNFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDWV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DC7</accession>
    <name>MURR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional regulator MurR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">MurPQ operon repressor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murR</name>
        <name type="ordered locus">SDY_2623</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator.</text>
    </comment>
    <comment type="pathway">
        <text>Amino-sugar metabolism; N-acetylmuramate degradation [regulation].</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000966455.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404169.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DC7"/>
    <dbReference type="SMR" id="Q32DC7"/>
    <dbReference type="STRING" id="300267.SDY_2623"/>
    <dbReference type="EnsemblBacteria" id="ABB62678">
        <property type="protein sequence ID" value="ABB62678"/>
        <property type="gene ID" value="SDY_2623"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2623"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3160"/>
    <dbReference type="HOGENOM" id="CLU_055769_0_2_6"/>
    <dbReference type="OMA" id="DHRIGSM"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043470">
        <property type="term" value="P:regulation of carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02108">
        <property type="entry name" value="HTH_type_MurR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022821">
        <property type="entry name" value="Tscrpt_reg_HTH_MurR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000387773" description="HTH-type transcriptional regulator MurR">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="128"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02108"/>
        </source>
    </evidence>
    <sequence length="285" mass="31370" checksum="4C7B40C75111AD1C" modified="2005-12-06" version="1">MLYLTKIRNAESEFTGNEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREKTNATALHLHSSITSDDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVTCEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLTDSPLRRLAHYTLDTVSGETEWRSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIERSSELTQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DL5</accession>
    <name>Q32DL5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellar regulator flk</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Fluke</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">div</name>
        <name evidence="4" type="ordered locus">SDY_2520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flk family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000615808.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404081.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DL5"/>
    <dbReference type="STRING" id="300267.SDY_2520"/>
    <dbReference type="EnsemblBacteria" id="ABB62590">
        <property type="protein sequence ID" value="ABB62590"/>
        <property type="gene ID" value="SDY_2520"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2520"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3035"/>
    <dbReference type="HOGENOM" id="CLU_063700_0_0_6"/>
    <dbReference type="OMA" id="FTHLVTW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023597">
        <property type="entry name" value="Flagellar_regulator_Flk"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020588">
        <property type="entry name" value="Flk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR020588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="331" mass="36694" checksum="DB73246D94F58810" modified="2005-12-06" version="1">MIQPISGPPPGQPPGQGDNLPSGAGNQPLSSQQRTSLESLMTKVTSLTQQQRAELWAGIRHDIGLSGDSPLLSRHFPAAEHNLAQRLLAAQKSHSARQLLAQLGEYLRLGNNRQAVTDYIRHNFGQTPLNQLLPEQLKTILTLLQEGKMVIPQPQQREATDRPLLPAEHNALKQLVTKLAAATGEPSKQIWQSMLELSGVKDGELIPAKLFNHLVTWLQARQTLSQQNTPTLESLQMTLKQPLDASELAALSAYIQQKYGLSAQSSLSSAQAEDILNQLYQRRIKGIDPRDMQPLLNPFPPMMDTLQNMATRPALWILLVAIILMLVWLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DY7</accession>
    <name>Q32DY7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dTDP-glucose enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybjT</name>
        <name evidence="3" type="ordered locus">SDY_2394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001136565.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403959.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DY7"/>
    <dbReference type="STRING" id="300267.SDY_2394"/>
    <dbReference type="EnsemblBacteria" id="ABB62468">
        <property type="protein sequence ID" value="ABB62468"/>
        <property type="gene ID" value="SDY_2394"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2394"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2887"/>
    <dbReference type="HOGENOM" id="CLU_007383_6_11_6"/>
    <dbReference type="OMA" id="YWLYFVT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="476" mass="53753" checksum="316F0DFD03666939" modified="2005-12-06" version="1">MPQRILVLGASGYIGQHLVRTLSQQGHQILAAARHVDRLAKLQLANVSCHKVDLSWPDNLPALLQDIDTVYFLVHSMGESGDFIAQERQVALNVRDALREVPVKQLIFLSSLQAPPHEQSDHLRARQATADILREANVPVTELRAGIIVGAGSAAFEVMRDMVYNLPVLTPPRWVRSRTTPIALENLLHYLVALLDHPASEHRIFEAAGPEVLSYQQQFEHFMAVSGKRRWLIPIPLPTRWISVWFLNVITSVPPTTARALIQGLKHDLLADDSALRALIPQRLIAFDDAVRSTLKEEEKLVNSSDWGYDTQAFARWRPEYGYFAKQAGFTVKTSASLAALWQVVNQIGGKERYFFGNILWQTRALMDRAIGHKLAKGRPEREYLQTGDAVDSWKVIVVEPEKQLTLLFGMKAPGLGRLCFTLEDKGDYRTIDVRAFWHPHGMPGLFYWVLMIPAHLFIFRGMAKQIARLAEQSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E20</accession>
    <name>Q32E20_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Formate acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pflB</name>
        <name evidence="11" type="ordered locus">SDY_2358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001292812.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403926.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E20"/>
    <dbReference type="STRING" id="300267.SDY_2358"/>
    <dbReference type="EnsemblBacteria" id="ABB62435">
        <property type="protein sequence ID" value="ABB62435"/>
        <property type="gene ID" value="SDY_2358"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2358"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2845"/>
    <dbReference type="HOGENOM" id="CLU_023898_0_0_6"/>
    <dbReference type="OMA" id="PYGGIKM"/>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="5 7 8" id="KW-0556">Organic radical</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="10">
        <location>
            <begin position="3"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="9">
        <location>
            <begin position="632"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="7">
        <location>
            <position position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="760" mass="85350" checksum="01BB1EB6AE0FFE49" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EC6</accession>
    <name>Q32EC6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403820.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EC6"/>
    <dbReference type="STRING" id="300267.SDY_2248"/>
    <dbReference type="EnsemblBacteria" id="ABB62329">
        <property type="protein sequence ID" value="ABB62329"/>
        <property type="gene ID" value="SDY_2248"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2248"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2717"/>
    <dbReference type="HOGENOM" id="CLU_093786_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="166" mass="17616" checksum="66A323459E66F341" modified="2005-12-06" version="1">MGVLSTFLVSWLGKDAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARVATRQSLVIMTLFAVLLATLIHHFGEQIIDFVAGDATTEVKALALTYLELTVLSYPAAAITLIGSGALRGAGNTKIPLLINGSLNILNIIISGILIYGLFSWSGLGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EH9</accession>
    <name>Q32EH9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000003174.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403767.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EH9"/>
    <dbReference type="STRING" id="300267.SDY_2190"/>
    <dbReference type="EnsemblBacteria" id="ABB62276">
        <property type="protein sequence ID" value="ABB62276"/>
        <property type="gene ID" value="SDY_2190"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2190"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2648"/>
    <dbReference type="HOGENOM" id="CLU_082324_2_0_6"/>
    <dbReference type="OMA" id="AYYRPWV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011392">
        <property type="entry name" value="Tellurite-R_TerY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020634">
        <property type="entry name" value="TerY_vWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="24169" checksum="F3C743B1247BEA79" modified="2005-12-06" version="1">MSEQITFATSDFASNPEPRCPCILLLDVSGSMSGRPINELNAGLVTFRDELLADPLALKRVELGIVTFGPVHVEQPFTSAANFFPPILFAQGDTPMGAAITKALDMVEERKREYRANGISYYRLWIFLITDGVPTDEWQAAANKVFQGEEDKKFAFFSIGVQGADMKTLAQISVRQPLSLQGLQFRELFSWLSSSLRSVSRSTPGTEVVLEAPKGWTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EQ9</accession>
    <name>Q32EQ9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yeiJ</name>
        <name evidence="9" type="ordered locus">SDY_2105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000382973.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403687.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EQ9"/>
    <dbReference type="STRING" id="300267.SDY_2105"/>
    <dbReference type="EnsemblBacteria" id="ABB62196">
        <property type="protein sequence ID" value="ABB62196"/>
        <property type="gene ID" value="SDY_2105"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2105"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2535"/>
    <dbReference type="HOGENOM" id="CLU_016813_4_2_6"/>
    <dbReference type="OMA" id="INEFFAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018270">
        <property type="entry name" value="C_nuclsd_transpt_met_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="PTHR10590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00804">
        <property type="entry name" value="nupC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_C" evidence="8">
        <location>
            <begin position="201"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="416" mass="43442" checksum="7993A870FB2C7BA8" modified="2005-12-06" version="1">MDVMRSVLGMVVLLTIAFLLSVNKKKISLRTVGAALVLQVVIGGIMLWLPPGRWVAEKVAFGVHKVMAYSDAGSAFIFGSLVGPKMDTLFDGAGFIFGFRVLPAIIFVTALVSILYYIGVMGILIRILGGIFQKALNISKIESFVAVTTIFLGQNEIPAIVKPFIDRLNRNELFTAICSGMASIAGSTMIGYAALGVPVEYLLAASLMAIPGGILFARMLSPATESSQVSFNNLSFTETPPKSIIEAAATGAMTGLKIAAGVATVVMAFVAIIALINGIIGGVGGWFGFEHASLESILGYLLAPLAWVMGVDWTDANLAGSLIGQKLAINEFVAYLNFSPYLQTAGTLDAKTVAIISFALCGFANFGSIGVVVGAFSAVAPHRAPEIAQLGLRALAAATLSNLMSATIAGFFIGLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FR8</accession>
    <name>YOAH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0181 protein YoaH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yoaH</name>
        <name type="ordered locus">SDY_1717</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0181 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000457334.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403328.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FR8"/>
    <dbReference type="SMR" id="Q32FR8"/>
    <dbReference type="STRING" id="300267.SDY_1717"/>
    <dbReference type="EnsemblBacteria" id="ABB61837">
        <property type="protein sequence ID" value="ABB61837"/>
        <property type="gene ID" value="SDY_1717"/>
    </dbReference>
    <dbReference type="GeneID" id="67415491"/>
    <dbReference type="KEGG" id="sdy:SDY_1717"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2071"/>
    <dbReference type="HOGENOM" id="CLU_185263_0_0_6"/>
    <dbReference type="OMA" id="QNHQGAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00507">
        <property type="entry name" value="UPF0181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005371">
        <property type="entry name" value="UPF0181"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03701">
        <property type="entry name" value="UPF0181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000236634" description="UPF0181 protein YoaH">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00507"/>
        </source>
    </evidence>
    <sequence length="59" mass="6554" checksum="580F1D2DA49BCCC0" modified="2005-12-06" version="1">MFAGLPSLTHEQQQKAVERIQELMAQGMSSGQAIALVAEELRANHSGERIVARFEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FV8</accession>
    <name>Q32FV8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_1676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000248636.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403288.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FV8"/>
    <dbReference type="STRING" id="300267.SDY_1676"/>
    <dbReference type="EnsemblBacteria" id="ABB61797">
        <property type="protein sequence ID" value="ABB61797"/>
        <property type="gene ID" value="SDY_1676"/>
    </dbReference>
    <dbReference type="GeneID" id="67415607"/>
    <dbReference type="KEGG" id="sdy:SDY_1676"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2022"/>
    <dbReference type="HOGENOM" id="CLU_041771_1_1_6"/>
    <dbReference type="OMA" id="CFWVVQP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="370" mass="39841" checksum="14B7AD79D8C56248" modified="2005-12-06" version="1">MVNVRQPRDVAQILLSVLFLAIMIVACLWIVQPFILGFAWAGTVVIATWPVLLRLQKIMFGRRSLAVLVMTLLLVMVFIIPIALLVNSIVDGSGPLIKAISSGDMTLPDLAWLNTIPVIGAKLYAGWHNLLDMGGTAIMAKVRPYIGTTTTWFVGQAAHIGRFMVHCALMLLFSALLYWRGEQVAQGIRHFATRLAGVRGDAAVLLAAQAIRAVALGVVVTALVQAVLGGIGLAVSGVPYATLLTVLMILSCLVQLGPLPVLIPAIIWLYWTGDTTWGTVLLVWSGVVGTLDNVIRPMLIRMGADLPLILILSGVIGGLIAFGMIGLFIGPVLLAVSWRLFAAWVEEVPPPTDQPEEILEELGEIEKPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G55</accession>
    <name>Q32G55_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative chloride channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_1564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403191.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G55"/>
    <dbReference type="STRING" id="300267.SDY_1564"/>
    <dbReference type="EnsemblBacteria" id="ABB61700">
        <property type="protein sequence ID" value="ABB61700"/>
        <property type="gene ID" value="SDY_1564"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1564"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1874"/>
    <dbReference type="HOGENOM" id="CLU_015263_5_2_6"/>
    <dbReference type="OMA" id="DIVTQPG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="445" mass="47098" checksum="E15954B6F1EADA34" modified="2005-12-06" version="1">MPQNSRPCFIAHFCSCIIYTSIRICALCSAVCLSQQSSVFSRPLPLPGFVMRCCYWSGCSSINDSGSLVNAATNLSPWRRLLTPALGGLAAVLLLMGWQKFTQQRPHAPTDYMEALQTEGQFDYAASLVKSLASLLVVTSGSAIGREGAMILLAALAASCFAQRFTPRQEWKLWIACGAAAGMAAAYRAPLAGSLFIAEVLFGTMMLASLGPVIISAVVALLVSNLINHSDALLYSVQLSVTVQARDYALIISTGVLAGLCGPLLLTLMNACHRGFVSLKLAPPWQLALGGLIVGLLSLFTPAVWGNGYSTVQSFLTAPPLLMIIAGIFLCKLCAVLASSGSGAPGGVFTPTLFIGLAIGMLYGRSLGLWFPDGEEITLLLGLTGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVIASVISRTLHRDSIYRQHTAQHS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G84</accession>
    <name>VES_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Putative protein Ves</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ves</name>
        <name type="ordered locus">SDY_1535</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ves family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Could be the product of a pseudogene. This sequence is much shorter than orthologs.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403162.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G84"/>
    <dbReference type="STRING" id="300267.SDY_1535"/>
    <dbReference type="EnsemblBacteria" id="ABB61671">
        <property type="protein sequence ID" value="ABB61671"/>
        <property type="gene ID" value="SDY_1535"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1535"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1839"/>
    <dbReference type="HOGENOM" id="CLU_090931_5_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010282">
        <property type="entry name" value="Uncharacterised_HutD/Ves"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37943">
        <property type="entry name" value="PTHR37943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05962">
        <property type="entry name" value="HutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="uncertain"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000315009" description="Putative protein Ves">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="91" mass="10576" checksum="06AEBCF3DD16DAEB" modified="2005-12-06" version="1">MEYFDMRKMSVNLWRNAAGETREICTFPPAKRDFYWRASIVSIAANGEFSLFPGMERIVTLLEGGEMFLESTDRFNHTLVMLPISRTCVFQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G89</accession>
    <name>ASTA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine N-succinyltransferase</fullName>
            <shortName evidence="1">AST</shortName>
            <ecNumber evidence="1">2.3.1.109</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AOST</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">astA</name>
        <name type="ordered locus">SDY_1530</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-arginine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-arginine</text>
            <dbReference type="Rhea" id="RHEA:15185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58241"/>
            <dbReference type="EC" id="2.3.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginine N-succinyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.109" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000989462.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403157.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G89"/>
    <dbReference type="SMR" id="Q32G89"/>
    <dbReference type="STRING" id="300267.SDY_1530"/>
    <dbReference type="EnsemblBacteria" id="ABB61666">
        <property type="protein sequence ID" value="ABB61666"/>
        <property type="gene ID" value="SDY_1530"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1530"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1833"/>
    <dbReference type="HOGENOM" id="CLU_057655_0_0_6"/>
    <dbReference type="OMA" id="RFFSMEF"/>
    <dbReference type="UniPathway" id="UPA00185">
        <property type="reaction ID" value="UER00279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008791">
        <property type="term" value="F:arginine N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:arginine catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019545">
        <property type="term" value="P:arginine catabolic process to succinate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01171">
        <property type="entry name" value="AstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007041">
        <property type="entry name" value="Arg_succinylTrfase_AstA/AruG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017650">
        <property type="entry name" value="Arginine_N-succinylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04958">
        <property type="entry name" value="AstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03243">
        <property type="entry name" value="arg_catab_AOST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03244">
        <property type="entry name" value="arg_catab_AstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0056">Arginine metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000262331" description="Arginine N-succinyltransferase">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01171"/>
        </source>
    </evidence>
    <sequence length="344" mass="38446" checksum="4B35A700C9374A9C" modified="2005-12-06" version="1">MMVIRSVERSDVSALMQLASKTGGGLTSLPANEATLSARIERAIKTWQGELPKSEQGYVFVLEDSETGTVAGICAIEVAVGLNDPWYNYRVGTLVHASKELNVYNALPTLFLSNDHTGSSELCTLFLDPDWRKEGNGYLLSKSRFMFMAAFRDKFNDKVVAEMRGVIDEHGYSPFWQSLGKRFFSMDFSRADFLCGTGQKAFIAELMPKHPIYTHFLSQEAQDVIGQVHPQTAPARAVLEKEGFRYRNYIDIFDGGPTLECDIDRVRAIRKSRLVEVAEGQPAQGDFPACLVANENYHHFRVVLVRTDPATERLILTAAQLDALKCHAGDRVRLVRLCAEEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GH7</accession>
    <name>Q32GH7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Crossover junction endodeoxyribonuclease rusA</fullName>
            <ecNumber evidence="13">3.1.21.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SDY_1435</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the rusA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="13"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000904112.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403069.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GH7"/>
    <dbReference type="STRING" id="300267.SDY_1435"/>
    <dbReference type="EnsemblBacteria" id="ABB61578">
        <property type="protein sequence ID" value="ABB61578"/>
        <property type="gene ID" value="SDY_1435"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1435"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1711"/>
    <dbReference type="HOGENOM" id="CLU_139466_0_2_6"/>
    <dbReference type="OMA" id="NWEVRAL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016281">
        <property type="entry name" value="Endonuclease_RusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008822">
        <property type="entry name" value="Endonuclease_RusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036614">
        <property type="entry name" value="RusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05866">
        <property type="entry name" value="RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001007">
        <property type="entry name" value="RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103084">
        <property type="entry name" value="SSF103084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 13 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB61578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="124" mass="14280" checksum="8E732EC9839CDFB7" modified="2005-12-06" version="1">MLIDLVLPYPPTVNTYWRRRGSTYFISEEGKRYRRAVALIVRQQRLKLSLSGRLAIKVIAEPPDKRRRDLDNILKAPLDALTHAGVLMDDEQFDEINIVRGQPVSGGRLGVKIYPIMHEEQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GI8</accession>
    <name>Q32GI8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
            <ecNumber evidence="2">2.7.7.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24898"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="2.7.7.65"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378691.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403058.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GI8"/>
    <dbReference type="STRING" id="300267.SDY_1423"/>
    <dbReference type="EnsemblBacteria" id="ABB61567">
        <property type="protein sequence ID" value="ABB61567"/>
        <property type="gene ID" value="SDY_1423"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1423"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1693"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_4_6"/>
    <dbReference type="OMA" id="HTWEINT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="283"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="326" mass="37418" checksum="44CF7A6ACBB47C63" modified="2005-12-06" version="1">MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLASLNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCEVYWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GN8</accession>
    <name>Q32GN8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_1372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cell inner membrane</location>
            <topology evidence="2 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000492802.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403008.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GN8"/>
    <dbReference type="STRING" id="300267.SDY_1372"/>
    <dbReference type="EnsemblBacteria" id="ABB61517">
        <property type="protein sequence ID" value="ABB61517"/>
        <property type="gene ID" value="SDY_1372"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1372"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1629"/>
    <dbReference type="HOGENOM" id="CLU_002755_1_1_6"/>
    <dbReference type="OMA" id="TLFGAQH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="869"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="920"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1033" mass="111480" checksum="DBE3651F8BA9F773" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GQ6</accession>
    <name>RIBA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="1">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ribA</name>
        <name type="ordered locus">SDY_1353</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001176302.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402990.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GQ6"/>
    <dbReference type="SMR" id="Q32GQ6"/>
    <dbReference type="STRING" id="300267.SDY_1353"/>
    <dbReference type="EnsemblBacteria" id="ABB61499">
        <property type="protein sequence ID" value="ABB61499"/>
        <property type="gene ID" value="SDY_1353"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1353"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1603"/>
    <dbReference type="HOGENOM" id="CLU_020273_2_1_6"/>
    <dbReference type="OMA" id="GQGFILY"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000040590" description="GTP cyclohydrolase-2">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="49"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <sequence length="196" mass="21864" checksum="CBA96988EB989FD7" modified="2005-12-06" version="1">MQLKRVVEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GW8</accession>
    <name>KITH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidine kinase</fullName>
            <ecNumber evidence="1">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tdk</name>
        <name type="ordered locus">SDY_1290</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000068066.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402928.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GW8"/>
    <dbReference type="SMR" id="Q32GW8"/>
    <dbReference type="STRING" id="300267.SDY_1290"/>
    <dbReference type="EnsemblBacteria" id="ABB61437">
        <property type="protein sequence ID" value="ABB61437"/>
        <property type="gene ID" value="SDY_1290"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1290"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1529"/>
    <dbReference type="HOGENOM" id="CLU_064400_2_1_6"/>
    <dbReference type="OMA" id="ENTVNHK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0237">DNA synthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000242804" description="Thymidine kinase">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <sequence length="205" mass="23356" checksum="648537D9E9194E51" modified="2005-12-06" version="1">MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNSSLFAEIRAEHEQQAIHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDFRGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQAGRPYNEGEQVVIGGNERYVSVCRKHYKEALEVGSLTAIQERHRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H93</accession>
    <name>Q32H93_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISSfl2 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378654.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402803.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H93"/>
    <dbReference type="STRING" id="300267.SDY_1155"/>
    <dbReference type="EnsemblBacteria" id="ABB61312">
        <property type="protein sequence ID" value="ABB61312"/>
        <property type="gene ID" value="SDY_1155"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1155"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1359"/>
    <dbReference type="HOGENOM" id="CLU_036902_2_3_6"/>
    <dbReference type="OMA" id="KTLIWER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="14"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="398" mass="43103" checksum="A9DE3D5EB050371A" modified="2005-12-06" version="1">MTESSDYESVQVFIGVDVGKDTHHAVAINRSGKRLFDKALPNDENKLRSLISDLKQHGQILLVVDQPATIGALPVAVARSEGVLVGYLPGLAMRRIADLHAGEAKTDARDAAIIAEAARTLPHALRTLKLADEQIAELSMLCGFDDDLAAQTTQASNRIRGLLTQIHPAPERVLGPRLVHPALLDLLQRYPSPEKLASLGEKKLAAQLCKLAPRLGKRLAADIAQALAEQTVVVPGTNAAAVVLPRLALQLITLRKQRDEVALEVEQRVLAHPLYPVLTSMPGVGVRTAARLPTEIACRAFASAAHLAAYAGLAPVTRRSGSSIRGEHPSRRGNKALKRALFLSAFAALRDPLSRAYYTRKMSQGKRHNQALIALARRRCDVLFAMMRDGTFYTPQGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HA3</accession>
    <name>ZNUC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc import ATP-binding protein ZnuC</fullName>
            <ecNumber evidence="1">7.2.2.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">znuC</name>
        <name type="ordered locus">SDY_1145</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP(in) + H2O(in) + Zn(2+)(out) = ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29795"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (ZnuC), two transmembrane proteins (ZnuB) and a solute-binding protein (ZnuA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000202986.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402793.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HA3"/>
    <dbReference type="SMR" id="Q32HA3"/>
    <dbReference type="STRING" id="300267.SDY_1145"/>
    <dbReference type="EnsemblBacteria" id="ABB61302">
        <property type="protein sequence ID" value="ABB61302"/>
        <property type="gene ID" value="SDY_1145"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1145"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1348"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_6"/>
    <dbReference type="OMA" id="GHDHVHP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015633">
        <property type="term" value="F:ABC-type zinc transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017882">
        <property type="entry name" value="ZnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42734:SF9">
        <property type="entry name" value="PTHR42734:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51298">
        <property type="entry name" value="ZNUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0864">Zinc transport</keyword>
    <feature type="chain" id="PRO_0000281551" description="Zinc import ATP-binding protein ZnuC">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="5"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01725"/>
        </source>
    </evidence>
    <sequence length="251" mass="27882" checksum="B5FE804E9195B67A" modified="2005-12-06" version="1">MTSLVSLENVSVSFGQRRVLSDVSLELKPGKILTLLGPNGAGKSTLVRVVLGLVTPDEGVIKRNGKLRIGYVPQKLYLDTTLPLTVKRFLRLRPGTHKEDILPALKRVQAGHLINAPMQKLSGGETQRVLLARALLNRPQLLVLDEPTQGVDVNGQVALYDLIDQLRRELDCGVLMVSHDLHLVMAKTDEVLCLNHHICCSGTPEVVSLHPEFISMFGPRGAEQLGIYRHHHNHRHDLQGRIVLRRGNDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HC1</accession>
    <name>Q32HC1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CopC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CopC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000168738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402775.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HC1"/>
    <dbReference type="STRING" id="300267.SDY_1127"/>
    <dbReference type="EnsemblBacteria" id="ABB61284">
        <property type="protein sequence ID" value="ABB61284"/>
        <property type="gene ID" value="SDY_1127"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1127"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1329"/>
    <dbReference type="HOGENOM" id="CLU_087859_4_2_6"/>
    <dbReference type="OMA" id="GHKTKGS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221121" description="CopC domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="5">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="124" mass="13456" checksum="8A08D40E0A3E43CA" modified="2005-12-06" version="1">MASTARSLRYALAILTTSLVTPSVWAHAHLMHQYPAANAQVTASPQAITLNFSEGVETGFSGAKITGPKNENIKTLPAKRNEQDQKQLIVPLADSLKPGTYTVDWHVVSVDGHKTKGHYTFSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HL4</accession>
    <name>Q32HL4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iroB</name>
        <name evidence="3" type="ordered locus">SDY_1026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020367.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402682.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HL4"/>
    <dbReference type="STRING" id="300267.SDY_1026"/>
    <dbReference type="CAZy" id="GT1">
        <property type="family name" value="Glycosyltransferase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61191">
        <property type="protein sequence ID" value="ABB61191"/>
        <property type="gene ID" value="SDY_1026"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1026"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1199"/>
    <dbReference type="HOGENOM" id="CLU_000537_7_4_6"/>
    <dbReference type="OMA" id="EPSFRAC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="DUF1205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="DUF1205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1205" evidence="2">
        <location>
            <begin position="165"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="371" mass="40305" checksum="A14323A310D40805" modified="2005-12-06" version="1">MRILFVGPPLYGLLYPVLSLAQAFRVNGHEVLIASGGQFAQKAAEAGLVVFDAAPGLDSEAGYRHHEAQRKKSNIGTQMGNFSFFSEEMADHLVEFAGHWRPDLIIYPPLGVIGPLIAAKYDIPVVMQTVGFGHTPWHIRGVTRSLTDAYRRHNVGATPRDMAWIDVTPPSMSILENDGEPIIPMQYVPYNGGAVWEPWWERRPERKRLLVSLGTVKPMVDGLDLIAWVMDSASEVDAEIILHISANARSDLRSLPSNVRLVDWIPMGVFLNGADGFIHHGGAGNTLTALHAGIPQIVFGQGADRPVNARVVAERGCGIIPGNVGLSSNMINAFLNNRSLRKASEEVAAEMAAQPCPGEVAKSLITMVQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HP6</accession>
    <name>Q32HP6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HP6"/>
    <dbReference type="EnsemblBacteria" id="ABB61159">
        <property type="protein sequence ID" value="ABB61159"/>
        <property type="gene ID" value="SDY_0992"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0992"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="45" mass="5334" checksum="CD337A5A6FCC4B74" modified="2005-12-06" version="1">MAALPNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HR4</accession>
    <name>TORD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein TorD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">torD</name>
        <name type="ordered locus">SDY_0972</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TorD/DmsD family. TorD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000209888.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402632.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HR4"/>
    <dbReference type="SMR" id="Q32HR4"/>
    <dbReference type="STRING" id="300267.SDY_0972"/>
    <dbReference type="EnsemblBacteria" id="ABB61141">
        <property type="protein sequence ID" value="ABB61141"/>
        <property type="gene ID" value="SDY_0972"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0972"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1127"/>
    <dbReference type="HOGENOM" id="CLU_077650_4_0_6"/>
    <dbReference type="OMA" id="PYASMYI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01150">
        <property type="entry name" value="TorD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023069">
        <property type="entry name" value="Chaperone_TorD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000065510" description="Chaperone protein TorD">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01150"/>
        </source>
    </evidence>
    <sequence length="199" mass="22442" checksum="E3F3FECD1EFF0B74" modified="2005-12-06" version="1">MTTLTAQQIACVYAWLAQLFSRELDDEQLTQIASAQMAEWFSLLKSEPPLTAAVNELENCVATLTVRDDARLELAADFCGLFLMTDKQAALPYASAYKQDEQEIKRLLVEAGMETSGNFNEPADHLAIYLELLSHLHFSLGEGTVPARRIDSLRQKTLTALWQWLPEFVARCHQYDSFGFYAALSQLLLVLVEGDHQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HX0</accession>
    <name>Q32HX0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yeiO</name>
        <name evidence="10" type="ordered locus">SDY_0909</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Set transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000551995.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402576.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HX0"/>
    <dbReference type="STRING" id="300267.SDY_0909"/>
    <dbReference type="EnsemblBacteria" id="ABB61085">
        <property type="protein sequence ID" value="ABB61085"/>
        <property type="gene ID" value="SDY_0909"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0909"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1052"/>
    <dbReference type="HOGENOM" id="CLU_055598_3_0_6"/>
    <dbReference type="OMA" id="FGFTVMY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004750">
        <property type="entry name" value="Sugar_efflux"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23535:SF2">
        <property type="entry name" value="PTHR23535:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00899">
        <property type="entry name" value="2A0120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="16"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="393" mass="42739" checksum="05AE7EA66474C5A4" modified="2005-12-06" version="1">MHNSPAVSSAKSFDLTSTAFLIVAFLTGIAVALQTPTLSIFLTDEVNARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLSAAVAFIVCGVMVWLFLPSMQKELPLATGTLEAPRRNRRDTLLLFVICTLMWGSNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPAILLGLQLLNAIFIGILGGIGMLYFQDLMPSQAGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLLRIKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HY3</accession>
    <name>Q32HY3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pseudouridine synthase</fullName>
            <ecNumber evidence="5">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsuA</name>
        <name evidence="7" type="ordered locus">SDY_0896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020263.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402563.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HY3"/>
    <dbReference type="STRING" id="300267.SDY_0896"/>
    <dbReference type="EnsemblBacteria" id="ABB61072">
        <property type="protein sequence ID" value="ABB61072"/>
        <property type="gene ID" value="SDY_0896"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0896"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1037"/>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_6"/>
    <dbReference type="OMA" id="HVPKTYE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S4" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="231" mass="25893" checksum="1C5C2154931C58F7" modified="2005-12-06" version="1">MRLDKFIAQQLGVSRAIAGREIRGNRVTVDGEIVRNAAFKLLPEHDVAYDGNPLAQQHGPRYFMLNKPQGYVCSTDDPDHPTVLYFLDEPVAWKLHAAGRLDIDTTGLVLMTDDGQWSHRITSPRHHCEKTYLVTLESPVADDTAEQFAKGVQLHNEKDLTKPAVLEVITPTQVRLTISEGRYHQVKRMFAAVGNHVVELHRERIGGITLDADLVPGEYRPLTEEEIASVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HY4</accession>
    <name>Q32HY4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yejH</name>
        <name evidence="3" type="ordered locus">SDY_0895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378641.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402562.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HY4"/>
    <dbReference type="STRING" id="300267.SDY_0895"/>
    <dbReference type="EnsemblBacteria" id="ABB61071">
        <property type="protein sequence ID" value="ABB61071"/>
        <property type="gene ID" value="SDY_0895"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0895"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1036"/>
    <dbReference type="HOGENOM" id="CLU_014765_1_0_6"/>
    <dbReference type="OMA" id="WIYQYHY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="241"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="586" mass="66533" checksum="4EDA238DDB7CB9D2" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I00</accession>
    <name>Q32I00_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Heme exporter protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ccmB</name>
        <name evidence="14" type="ordered locus">SDY_0878</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the CcmB/CycW/HelB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000971730.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402546.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I00"/>
    <dbReference type="SMR" id="Q32I00"/>
    <dbReference type="STRING" id="300267.SDY_0878"/>
    <dbReference type="EnsemblBacteria" id="ABB61055">
        <property type="protein sequence ID" value="ABB61055"/>
        <property type="gene ID" value="SDY_0878"/>
    </dbReference>
    <dbReference type="GeneID" id="66673905"/>
    <dbReference type="KEGG" id="sdy:SDY_0878"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1013"/>
    <dbReference type="HOGENOM" id="CLU_079069_1_0_6"/>
    <dbReference type="OMA" id="VKCLAHW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003544">
        <property type="entry name" value="Cyt_c_biogenesis_CcmB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026031">
        <property type="entry name" value="Cyt_c_CcmB_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30070">
        <property type="entry name" value="PTHR30070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03379">
        <property type="entry name" value="CcmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002764">
        <property type="entry name" value="CcmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01190">
        <property type="entry name" value="ccmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="11 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB61055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="220" mass="23619" checksum="8DC1EEB8168401A3" modified="2005-12-06" version="1">MMFWRIFRLELRVAFRHSAEIANPLWFFLIVITLFPLSIGPEPQLLARIAPGIIWVAALLSSLLALERLFRDDLQDGSLEQLMLLPLPLPAVVLAKVMAHWMVTGLPLLILSPLVAMLLGMDVYGWQVMALTLLLGTPTLGFLGAPGVALTVGLKRGGVLLSILVLPLTIPLLIFATAAMDAASMHLPVDGYLAILGALLAGTATLSPFATAAALRISIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I30</accession>
    <name>Q32I30_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402516.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I30"/>
    <dbReference type="STRING" id="300267.SDY_0846"/>
    <dbReference type="EnsemblBacteria" id="ABB61027">
        <property type="protein sequence ID" value="ABB61027"/>
        <property type="gene ID" value="SDY_0846"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0846"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.977"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="100"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="273" mass="31686" checksum="A3D8973BE512E07D" modified="2005-12-06" version="1">MFGVHRSSYRYWKNRPEKPDGRRAVLRSQVLELHGISHGSAGARSIATMATRRGYQMGRWLAGRLMKELGLVSCQQPTHRYKRGGHEHVAIPNYLERQFAVTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKPGGVMFHSDQGSHYTSRQFRQLLWRYQIRQSMSRRGNCWDNSPMERFFRSLKNEWMPVVGYVSFSEAAHAITDYIVGYYSALRPHEYNGGLPPNESENRYWKNSNSVASFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I76</accession>
    <name>Q32I76_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybiB</name>
        <name evidence="4" type="ordered locus">SDY_0799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000386528.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402470.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I76"/>
    <dbReference type="STRING" id="300267.SDY_0799"/>
    <dbReference type="EnsemblBacteria" id="ABB60981">
        <property type="protein sequence ID" value="ABB60981"/>
        <property type="gene ID" value="SDY_0799"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0799"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.922"/>
    <dbReference type="HOGENOM" id="CLU_068658_0_0_6"/>
    <dbReference type="OMA" id="AMRIKGE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="320" mass="35058" checksum="2DDE76EB5AA4EC36" modified="2005-12-06" version="1">MDYRKIIKEIGRGKNHARDLDRDTARGLYAHMLNGEVPDLELGGVLIALRIKGEGEAEMLGFYEAMQNHTIKLTPPAGKPMPIVIPSYNGARKQANLTPLLAILLHKLGFPVVVHGVSEDPTRVLTETIFELMGITPTLHGGQAQAKLDEHQPVFMPVGAFCPPLEKQLAMRWRMGMRNSAHTLAKLATPFAEGEALRLSSVSHPEYIGRVAKFFSDIGGRALLMHGTEGEVYANPQHCPQINLIDREGMRVLYEKQDPAGSELLPQAKDPETTAQWIERCLAGSEPIPESLKIQMACCLVATGEAATISDGLARVNQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I84</accession>
    <name>Q32I84_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1471 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybiM</name>
        <name evidence="3" type="ordered locus">SDY_0791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I84"/>
    <dbReference type="STRING" id="300267.SDY_0791"/>
    <dbReference type="EnsemblBacteria" id="ABB60973">
        <property type="protein sequence ID" value="ABB60973"/>
        <property type="gene ID" value="SDY_0791"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0791"/>
    <dbReference type="HOGENOM" id="CLU_2023628_0_0_6"/>
    <dbReference type="OMA" id="DKAHRQG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036275">
        <property type="entry name" value="YdgH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010854">
        <property type="entry name" value="YdgH/BhsA/McbA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07338">
        <property type="entry name" value="DUF1471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159871">
        <property type="entry name" value="SSF159871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DUF1471" evidence="2">
        <location>
            <begin position="82"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="134" mass="14729" checksum="DEC9DC57E78DA37A" modified="2005-12-06" version="1">MHVIDLSYFVKIYRSKNKRISVNFLRHFHRPSDLHLSGTTRCIYEDIIMKKCLTLLIATVLSGISLTAYAAQPMSNLDSGQLRPTGTVSATGASNLSDLEDKLAEKAREQGAKGYVINSAGGNDQMFGTATIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IC8</accession>
    <name>Q32IC8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybjC</name>
        <name evidence="2" type="ordered locus">SDY_0745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001201584.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402418.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IC8"/>
    <dbReference type="STRING" id="300267.SDY_0745"/>
    <dbReference type="EnsemblBacteria" id="ABB60929">
        <property type="protein sequence ID" value="ABB60929"/>
        <property type="gene ID" value="SDY_0745"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0745"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.859"/>
    <dbReference type="HOGENOM" id="CLU_161289_1_0_6"/>
    <dbReference type="OMA" id="EFIGMMS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010815">
        <property type="entry name" value="DUF1418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07214">
        <property type="entry name" value="DUF1418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="95" mass="10539" checksum="B46EE0F0617822D9" modified="2005-12-06" version="1">MRAIGKLPKSVLILEFIGMMSLAVALLSVSDTLSLPEPFSRPEVQILMIFLGVLLMLPAAVVVILQVAKRLAPQLMNRPPQYSRSEREKDNDANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ID1</accession>
    <name>Q32ID1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sensory transduction regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybjN</name>
        <name evidence="1" type="ordered locus">SDY_0742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020065.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402415.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ID1"/>
    <dbReference type="STRING" id="300267.SDY_0742"/>
    <dbReference type="EnsemblBacteria" id="ABB60926">
        <property type="protein sequence ID" value="ABB60926"/>
        <property type="gene ID" value="SDY_0742"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0742"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.856"/>
    <dbReference type="HOGENOM" id="CLU_115861_0_0_6"/>
    <dbReference type="OMA" id="HMQNIDG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="158" mass="17696" checksum="9B28B96A0BAE5298" modified="2005-12-06" version="1">MTSLVVPGLDTLRQWLDDLGMSFFECDNCQALHLPHMQNFDSVFDAKIDLIDNTILFSAMAEVRPSAVLPLAADLSAINASSLTVKAFLDMQDDNLPKLVVCQSLSVMQGVTYEQFAWFVRQSEEQISMVILEANAHQLLLPTDDEGQNNVTENYFLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-17" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IR3</accession>
    <name>YBEY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybeY</name>
        <name type="ordered locus">SDY_0595</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000084456.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402283.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IR3"/>
    <dbReference type="SMR" id="Q32IR3"/>
    <dbReference type="STRING" id="300267.SDY_0595"/>
    <dbReference type="EnsemblBacteria" id="ABB60794">
        <property type="protein sequence ID" value="ABB60794"/>
        <property type="gene ID" value="SDY_0595"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0595"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.699"/>
    <dbReference type="HOGENOM" id="CLU_106710_0_1_6"/>
    <dbReference type="OMA" id="RMRIHPL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000284311" description="Endoribonuclease YbeY">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <sequence length="155" mass="17483" checksum="9BA1A9B4BD832B1D" modified="2005-12-06" version="1">MSQVILDLQLACEDNSGLPEESQFQTWLNAVIPQFQEESEVTILVVDTAESHSLNLTYRGKDKPTNVLSFPFEVPPGMEMSLLGDLVICRQVVEKEAQEQGKPLEAHWAHMVVHGSLHLLGYDHIEDDEAEEMEALETEIMLALGYEDPYIAEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J13</accession>
    <name>Q32J13_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_0487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402183.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J13"/>
    <dbReference type="STRING" id="300267.SDY_0487"/>
    <dbReference type="EnsemblBacteria" id="ABB60694">
        <property type="protein sequence ID" value="ABB60694"/>
        <property type="gene ID" value="SDY_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0487"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.575"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="95" mass="10681" checksum="750A480C4E68C479" modified="2005-12-06" version="1">MYDGVFEVLQWLLFLSAVPPVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVSLNTISRHLKNSGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J85</accession>
    <name>Q32J85_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybbJ</name>
        <name evidence="4" type="ordered locus">SDY_0411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000970312.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402111.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J85"/>
    <dbReference type="STRING" id="300267.SDY_0411"/>
    <dbReference type="EnsemblBacteria" id="ABB60622">
        <property type="protein sequence ID" value="ABB60622"/>
        <property type="gene ID" value="SDY_0411"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0411"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.488"/>
    <dbReference type="HOGENOM" id="CLU_116732_4_0_6"/>
    <dbReference type="OMA" id="PGVFLFW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="60"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="152" mass="16892" checksum="6E3223499E338AE0" modified="2005-12-06" version="1">MMELIVVHPHIFWLSLGGLLLAAEMLGGNGYLLWSGVAAVITGLVVWLVPLGWEWQGVMFAVLTLLAAWLWWKWLSRRVREQKHSNSHLNQRGQQLIGRRFVLESPLVNGRGHMRVGDSSWPVSASEDLGAGTHVEVIAIEGITLIIRAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JB4</accession>
    <name>Q32JB4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402082.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JB4"/>
    <dbReference type="STRING" id="300267.SDY_0380"/>
    <dbReference type="EnsemblBacteria" id="ABB60593">
        <property type="protein sequence ID" value="ABB60593"/>
        <property type="gene ID" value="SDY_0380"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0380"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.451"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_14_6"/>
    <dbReference type="OMA" id="TPHALME"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="57"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="160" mass="18660" checksum="8B1249B683F9E0D5" modified="2005-12-06" version="1">MPFYFRKECQLNSGYLIGSDYANHIARRMVVPPYRTGGQAQFIEQPVPKNTHDERINLLLDYLRQNIAQQHDLDSLAQRVMMSRRTLTRHFMKATGSSIAEWLITERLRRSQELLGSSQLPVERIAAEVGFLSPVTWRQHFKSHFVVSPAEWRKTFRGMA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JF8</accession>
    <name>ACPH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Putative acyl carrier protein phosphodiesterase</fullName>
            <shortName>ACP phosphodiesterase</shortName>
            <ecNumber>3.1.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">acpH</name>
        <name type="ordered locus">SDY_0330</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>H2O + holo-[ACP] = (R)-4'-phosphopantetheine + apo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="3.1.4.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AcpH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Could be the product of a pseudogene. The N-terminus is shorter than in related proteins.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.14"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JF8"/>
    <dbReference type="SMR" id="Q32JF8"/>
    <dbReference type="STRING" id="300267.SDY_0330"/>
    <dbReference type="EnsemblBacteria" id="ABB60549">
        <property type="protein sequence ID" value="ABB60549"/>
        <property type="gene ID" value="SDY_0330"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0330"/>
    <dbReference type="HOGENOM" id="CLU_099370_1_0_6"/>
    <dbReference type="OMA" id="MNFLAHI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008770">
        <property type="term" value="F:[acyl-carrier-protein] phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007431">
        <property type="entry name" value="ACP_PD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38764">
        <property type="entry name" value="PTHR38764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04336">
        <property type="entry name" value="ACP_PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="uncertain"/>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000226275" description="Putative acyl carrier protein phosphodiesterase">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="143" mass="17464" checksum="10319F9D40D95290" modified="2005-12-06" version="1">MTDNLPEVREAREWFRSETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFVCYAREQVMTILPDSLPRFINLNNYLWSEQWLVRYRDMDFIQNVLNGMASRRPRLDALRDSWYDLNAHYAALETRFWQFYPRMMAQVSRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JH3</accession>
    <name>Q32JH3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378564.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402023.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JH3"/>
    <dbReference type="EnsemblBacteria" id="ABB60534">
        <property type="protein sequence ID" value="ABB60534"/>
        <property type="gene ID" value="SDY_0315"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0315"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.364"/>
    <dbReference type="HOGENOM" id="CLU_2861036_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="79" mass="9479" checksum="53116635B21220A5" modified="2005-12-06" version="1">MKKVPLTAQLIAKYKMDDQLDQLLVPREIQDEIKSKIRDKIDELSKNLFNTMTETIENNFDDIFRQQSENMSNYYEFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JJ1</accession>
    <name>Q32JJ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JJ1"/>
    <dbReference type="EnsemblBacteria" id="ABB60516">
        <property type="protein sequence ID" value="ABB60516"/>
        <property type="gene ID" value="SDY_0297"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0297"/>
    <dbReference type="HOGENOM" id="CLU_195173_0_0_6"/>
    <dbReference type="OMA" id="ENXPGIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="9962" checksum="A8888B3C7B90E45F" modified="2005-12-06" version="1">MGRVAGHRLCLSSLSWSRKHRVKTHLQLSALFQYVAKDFMKNGLRAVLFCLDFALFAQHSDENCPGIVKKYATARNNRSRLIKVMPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JK7</accession>
    <name>FOLD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="2">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="2">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="2">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="2">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="2" type="primary">folD</name>
        <name type="ordered locus">SDY_0281</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="2"/>
    <dbReference type="EC" id="3.5.4.9" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000729153.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401989.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JK7"/>
    <dbReference type="SMR" id="Q32JK7"/>
    <dbReference type="STRING" id="300267.SDY_0281"/>
    <dbReference type="EnsemblBacteria" id="ABB60500">
        <property type="protein sequence ID" value="ABB60500"/>
        <property type="gene ID" value="SDY_0281"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0281"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.322"/>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_6"/>
    <dbReference type="OMA" id="HIVGRPM"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000268498" description="Bifunctional protein FolD">
        <location>
            <begin position="2"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <sequence length="288" mass="30995" checksum="EC7492DD72145807" modified="2007-01-23" version="3">MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDALNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKHASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JU0</accession>
    <name>RS2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsB</name>
        <name type="ordered locus">SDY_0185</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000246882.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401906.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JU0"/>
    <dbReference type="SMR" id="Q32JU0"/>
    <dbReference type="STRING" id="300267.SDY_0185"/>
    <dbReference type="EnsemblBacteria" id="ABB60417">
        <property type="protein sequence ID" value="ABB60417"/>
        <property type="gene ID" value="SDY_0185"/>
    </dbReference>
    <dbReference type="GeneID" id="67416245"/>
    <dbReference type="KEGG" id="sdy:SDY_0185"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.214"/>
    <dbReference type="HOGENOM" id="CLU_040318_1_2_6"/>
    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000004072" description="30S ribosomal protein S2">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <sequence length="241" mass="26744" checksum="87A38C696115212E" modified="2005-12-06" version="1">MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAVKDAALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQDLASQAEESFVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JU6</accession>
    <name>Q32JU6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yaeG</name>
        <name evidence="3" type="ordered locus">SDY_0179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JU6"/>
    <dbReference type="STRING" id="300267.SDY_0179"/>
    <dbReference type="EnsemblBacteria" id="ABB60411">
        <property type="protein sequence ID" value="ABB60411"/>
        <property type="gene ID" value="SDY_0179"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0179"/>
    <dbReference type="HOGENOM" id="CLU_043769_1_0_6"/>
    <dbReference type="OMA" id="TMVVGNS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008599">
        <property type="entry name" value="Diacid_rec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05651">
        <property type="entry name" value="Diacid_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diacid_rec" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="2">
        <location>
            <begin position="136"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="266" mass="29630" checksum="5006DAFF099B5ABF" modified="2005-12-06" version="1">MAQDIVARTMRIIDTNINVMDARGRIIGSGDRERIGELHEGALLVLSQGRVVDIDDAVARHLHGVRQGINLPLRLEGEIVGVIGLTGEPENLRKYGELVCMTAEMMLEQSRLMHLLAQDSRLREELVMNLIQAEENTPALTEWAQRLGIDLNQPRVVAIVEVDSGQLGVDSAMAELPQLQNALTTPERNNLVAIVSLTEMVVLKPALNSFGRWDAEDHRKRVEQLITRMKEYGQLRFRVSLGNYFSGPGSIARSYRTAKTTMVVGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JV3</accession>
    <name>CLCA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">H(+)/Cl(-) exchange transporter ClcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clcA</name>
        <name evidence="1" type="synonym">eriC</name>
        <name type="ordered locus">SDY_0171</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000845408.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401893.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JV3"/>
    <dbReference type="SMR" id="Q32JV3"/>
    <dbReference type="STRING" id="300267.SDY_0171"/>
    <dbReference type="EnsemblBacteria" id="ABB60404">
        <property type="protein sequence ID" value="ABB60404"/>
        <property type="gene ID" value="SDY_0171"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0171"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.197"/>
    <dbReference type="HOGENOM" id="CLU_015263_7_0_6"/>
    <dbReference type="OMA" id="FAVCVMT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01128">
        <property type="entry name" value="CLC_ClcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023861">
        <property type="entry name" value="Cl-channel_ClcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0868">Chloride</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000301543" description="H(+)/Cl(-) exchange transporter ClcA">
        <location>
            <begin position="1"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="282"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
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    </feature>
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        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Note=Loop between two helices" evidence="1">
        <location>
            <begin position="402"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Note=Loop between two helices" evidence="1">
        <location>
            <begin position="417"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Selectivity filter part_1" evidence="1">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Selectivity filter part_2" evidence="1">
        <location>
            <begin position="146"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Selectivity filter part_3" evidence="1">
        <location>
            <begin position="355"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>chloride</name>
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        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="357"/>
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        <ligand>
            <name>chloride</name>
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        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="445"/>
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        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
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    <feature type="site" description="Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport" evidence="1">
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            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Mediates proton transfer from the protein to the inner aqueous phase" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01128"/>
        </source>
    </evidence>
    <sequence length="473" mass="50335" checksum="72255396D9676B23" modified="2005-12-06" version="1">MKTDTPSLETPQAARLRRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDVFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQLARSKAASASENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JY7</accession>
    <name>Q32JY7_SHIDS</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JY7"/>
    <dbReference type="EnsemblBacteria" id="ABB60370">
        <property type="protein sequence ID" value="ABB60370"/>
        <property type="gene ID" value="SDY_0135"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0135"/>
    <dbReference type="HOGENOM" id="CLU_3364697_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="35" mass="3893" checksum="22B635FD88C2D602" modified="2005-12-06" version="1">MLLHTSVGRLQVVEDAVFLFLHTDKCGALGQFFQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K68</accession>
    <name>ISPH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="1">HMBPP reductase</shortName>
            <ecNumber evidence="1">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispH</name>
        <name type="ordered locus">SDY_0051</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001166395.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401778.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K68"/>
    <dbReference type="SMR" id="Q32K68"/>
    <dbReference type="STRING" id="300267.SDY_0051"/>
    <dbReference type="EnsemblBacteria" id="ABB60289">
        <property type="protein sequence ID" value="ABB60289"/>
        <property type="gene ID" value="SDY_0051"/>
    </dbReference>
    <dbReference type="GeneID" id="58460832"/>
    <dbReference type="KEGG" id="sdy:SDY_0051"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.55"/>
    <dbReference type="HOGENOM" id="CLU_027486_1_0_6"/>
    <dbReference type="OMA" id="HNKYVVD"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000021178" description="4-hydroxy-3-methylbut-2-enyl diphosphate reductase">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <sequence length="316" mass="34775" checksum="0E7B378BD49AB771" modified="2005-12-06" version="1">MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELRVDIREVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K89</accession>
    <name>Q32K89_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yacC</name>
        <name evidence="1" type="ordered locus">SDY_0029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K89"/>
    <dbReference type="STRING" id="300267.SDY_0029"/>
    <dbReference type="EnsemblBacteria" id="ABB60269">
        <property type="protein sequence ID" value="ABB60269"/>
        <property type="gene ID" value="SDY_0029"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0029"/>
    <dbReference type="HOGENOM" id="CLU_142137_0_0_6"/>
    <dbReference type="OMA" id="QNRWDLT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019114">
        <property type="entry name" value="Chap_lipoprot_PulS/OutS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038432">
        <property type="entry name" value="PulS/OutS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09691">
        <property type="entry name" value="T2SS_PulS_OutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="156" mass="17532" checksum="34921783550460AF" modified="2005-12-06" version="1">MSIVLPLTGRSSRRHNLIDNNGRRLARSVLTFIFFKPLVEAMKTFFRTVLFGSLMAVCANSYALSESEAEDMADLTAVFVFLKNDCGYQNLPNGQIRRALVFFAQQNQWDLSNYDTFDMKALGEDSYRDLSGIGIPVAKKCKALARDSLSLLAYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Q5</accession>
    <name>Q326Q5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Surface presentation of antigens protein SpaO</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">spa33</name>
        <name evidence="5" type="ordered locus">SDY_P190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Sd197</strain>
            <plasmid evidence="6">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000944986.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406191.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Q5"/>
    <dbReference type="EnsemblBacteria" id="ABB64703">
        <property type="protein sequence ID" value="ABB64703"/>
        <property type="gene ID" value="SDY_P190"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P190"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5741"/>
    <dbReference type="HOGENOM" id="CLU_949621_0_0_6"/>
    <dbReference type="OMA" id="DWVIRID"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003283">
        <property type="entry name" value="T3SS_OMP_SpaO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01339">
        <property type="entry name" value="TYPE3OMOPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="FliMN_C" evidence="4">
        <location>
            <begin position="222"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="293" mass="33352" checksum="BA38E9AA34A90FE0" modified="2005-12-06" version="1">MLRLKHFDANEKLQILYAKQLCERFAIQTFKNKFTGSESLVTLTSVCGDWVIRIDTLSFLKKKYEVFSGFSTQESLLHLSKCVFIESSSVFSIPELSDKITFRITNEIQFATTGSHLCCFSSSLGIIYLDKMPVLRNQVSLDLLHHLLEFCLGSSNVRLATLKRIRTGDIIIVQKLYNLLLCNQVIIGDYIVNDNNEAKINLSESNGESDHTEVSLALFNYDDINVKVDFILLEKKMTINELKMYVENELFKFPDDIVKHVNIKVNGSLVGHGELVSIEDGYGIEISSWMVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q327I1</accession>
    <name>Q327I1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406015.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327I1"/>
    <dbReference type="EnsemblBacteria" id="ABB64527">
        <property type="protein sequence ID" value="ABB64527"/>
        <property type="gene ID" value="SDY_P014"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P014"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5544"/>
    <dbReference type="HOGENOM" id="CLU_141050_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14739" checksum="EF3EDBCA5D3D2726" modified="2005-12-06" version="1">MTESRQEKLIWLRAQMKLTSLCWALKELAKDIWSRPWSEERRNDWQRWLSLAANSDVPMMKNVAKTIGKRLYGILNAMRHGVSNGNAEALNSKIRLLRIKAKGYRNRERFKLGVMFHYGKLNMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q327M4</accession>
    <name>Q327M4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">[Ribosomal protein S18]-alanine N-acetyltransferase</fullName>
            <ecNumber evidence="5 6">2.3.1.266</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rimI</name>
        <name evidence="8" type="ordered locus">SDY_4632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Acetylates the N-terminal alanine of ribosomal protein S18.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]</text>
            <dbReference type="Rhea" id="RHEA:43756"/>
            <dbReference type="Rhea" id="RHEA-COMP:10676"/>
            <dbReference type="Rhea" id="RHEA-COMP:10677"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.266"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the acetyltransferase family. RimI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.266" evidence="5 6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001092460.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405972.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327M4"/>
    <dbReference type="STRING" id="300267.SDY_4632"/>
    <dbReference type="EnsemblBacteria" id="ABB64481">
        <property type="protein sequence ID" value="ABB64481"/>
        <property type="gene ID" value="SDY_4632"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4632"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5490"/>
    <dbReference type="HOGENOM" id="CLU_013985_23_2_6"/>
    <dbReference type="OMA" id="GERYLNY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:ribosomal protein S5-alanine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017189">
        <property type="term" value="P:N-terminal peptidyl-alanine acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02210">
        <property type="entry name" value="RimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043690">
        <property type="entry name" value="RimI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="5">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="148" mass="16637" checksum="AA78412D38D42F9E" modified="2005-12-06" version="1">MNTISSLETTDLPAAYHIEQRAHAFPWSEKTFASNQGERYLNFQLTQNGKMAAFAITQVVLDEATLFNIAVDPDYQRQGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGFNEATIRRNYYPTKDGREDAIIMALPISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q327P1</accession>
    <name>Q327P1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjiX</name>
        <name evidence="1" type="ordered locus">SDY_4606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000467859.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405955.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327P1"/>
    <dbReference type="STRING" id="300267.SDY_4606"/>
    <dbReference type="EnsemblBacteria" id="ABB64464">
        <property type="protein sequence ID" value="ABB64464"/>
        <property type="gene ID" value="SDY_4606"/>
    </dbReference>
    <dbReference type="GeneID" id="67416027"/>
    <dbReference type="KEGG" id="sdy:SDY_4606"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5459"/>
    <dbReference type="HOGENOM" id="CLU_171734_1_1_6"/>
    <dbReference type="OMA" id="KGGPKCC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007423">
        <property type="entry name" value="Sel_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38453">
        <property type="entry name" value="PTHR38453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04328">
        <property type="entry name" value="Sel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7729" checksum="D98E90A1A843219E" modified="2005-12-06" version="1">MFGNLGQAKKYLGQAAKMLIGIPDYDNYVEHMKTNHPDKPYMSYEEFFRERQNARYGGDGKGGMRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q327S2</accession>
    <name>Q327S2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione-binding protein GsiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dppA</name>
        <name evidence="9" type="ordered locus">SDY_4567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001222888.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405924.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327S2"/>
    <dbReference type="STRING" id="300267.SDY_4567"/>
    <dbReference type="EnsemblBacteria" id="ABB64433">
        <property type="protein sequence ID" value="ABB64433"/>
        <property type="gene ID" value="SDY_4567"/>
    </dbReference>
    <dbReference type="GeneID" id="58390097"/>
    <dbReference type="KEGG" id="sdy:SDY_4567"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5406"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_0_6"/>
    <dbReference type="OMA" id="YIAYNVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220921" description="Glutathione-binding protein GsiB" evidence="7">
        <location>
            <begin position="29"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="8">
        <location>
            <begin position="73"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="535" mass="60312" checksum="A12219CFDB7B18A0" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q327S8</accession>
    <name>Q327S8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhjT</name>
        <name evidence="2" type="ordered locus">SDY_4560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327S8"/>
    <dbReference type="STRING" id="300267.SDY_4560"/>
    <dbReference type="EnsemblBacteria" id="ABB64427">
        <property type="protein sequence ID" value="ABB64427"/>
        <property type="gene ID" value="SDY_4560"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4560"/>
    <dbReference type="HOGENOM" id="CLU_198346_0_0_6"/>
    <dbReference type="OMA" id="KANRKHD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019995">
        <property type="entry name" value="Cellulose_BcsF/YhjT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11120">
        <property type="entry name" value="CBP_BcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03493">
        <property type="entry name" value="cellullose_BcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="62" mass="7263" checksum="6674F7F77E4CEC18" modified="2005-12-06" version="1">MTISDIIEIIVVCTLIFFPLGYLARHSLRRIRDTLRLFFAKPRYVKPAGTLRRTEKARATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q327T3</accession>
    <name>Q327T3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Cellulose synthase catalytic subunit [UDP-forming]</fullName>
            <ecNumber evidence="5 10">2.4.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yhjO</name>
        <name evidence="13" type="ordered locus">SDY_4553</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-beta-D-glucosyl](n+1) + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:19929"/>
            <dbReference type="Rhea" id="RHEA-COMP:10033"/>
            <dbReference type="Rhea" id="RHEA-COMP:10034"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18246"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Glycan metabolism; bacterial cellulose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.12" evidence="5 10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327T3"/>
    <dbReference type="STRING" id="300267.SDY_4553"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64422">
        <property type="protein sequence ID" value="ABB64422"/>
        <property type="gene ID" value="SDY_4553"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4553"/>
    <dbReference type="HOGENOM" id="CLU_011907_5_0_6"/>
    <dbReference type="OMA" id="QRLCYAN"/>
    <dbReference type="UniPathway" id="UPA00694"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016760">
        <property type="term" value="F:cellulose synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003919">
        <property type="entry name" value="Cell_synth_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01439">
        <property type="entry name" value="CELLSNTHASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03030">
        <property type="entry name" value="CelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0973">c-di-GMP</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0135">Cellulose biosynthesis</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="11">
        <location>
            <begin position="292"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ" evidence="12">
        <location>
            <begin position="710"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB64422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="888" mass="101602" checksum="283E870F3605E58E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q327U9</accession>
    <name>Q327U9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Diacylglycerol kinase</fullName>
            <ecNumber evidence="5 18">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">dgkA</name>
        <name evidence="19" type="ordered locus">SDY_4532</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 18">Cell inner membrane</location>
            <topology evidence="3 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="5 18"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000002907.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405897.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327U9"/>
    <dbReference type="SMR" id="Q327U9"/>
    <dbReference type="STRING" id="300267.SDY_4532"/>
    <dbReference type="EnsemblBacteria" id="ABB64406">
        <property type="protein sequence ID" value="ABB64406"/>
        <property type="gene ID" value="SDY_4532"/>
    </dbReference>
    <dbReference type="GeneID" id="66672043"/>
    <dbReference type="KEGG" id="sdy:SDY_4532"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5356"/>
    <dbReference type="HOGENOM" id="CLU_112343_3_1_6"/>
    <dbReference type="OMA" id="ITNEWHE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14264">
        <property type="entry name" value="DAGK_IM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033718">
        <property type="entry name" value="DAGK_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01069">
        <property type="entry name" value="DAGK_PROKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 18 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABB64406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="122" mass="13245" checksum="D5B4F86925FA6A17" modified="2005-12-06" version="1">MANNTTGFTRIIKAAGYSWKGLRAAWINEAAFRQEGVAVLLAVVIACWLDVDAITRVLLISSVMLVMIVEILNSAIEAVVDRIGSEYHELSGRAKDMGSAAVLIAIIVAVITWCILLWSHFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q327V0</accession>
    <name>LEXA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LexA repressor</fullName>
            <ecNumber evidence="1">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lexA</name>
        <name type="ordered locus">SDY_4531</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000646078.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405896.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327V0"/>
    <dbReference type="SMR" id="Q327V0"/>
    <dbReference type="STRING" id="300267.SDY_4531"/>
    <dbReference type="MEROPS" id="S24.001"/>
    <dbReference type="EnsemblBacteria" id="ABB64405">
        <property type="protein sequence ID" value="ABB64405"/>
        <property type="gene ID" value="SDY_4531"/>
    </dbReference>
    <dbReference type="GeneID" id="67415408"/>
    <dbReference type="KEGG" id="sdy:SDY_4531"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5355"/>
    <dbReference type="HOGENOM" id="CLU_066192_45_3_6"/>
    <dbReference type="OMA" id="HVWLLPH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000001344" description="LexA repressor">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="1">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <sequence length="202" mass="22358" checksum="7E8816A32C19EE71" modified="2005-12-06" version="1">MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVIEIVSGASRGIRLLQEEEEGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPNADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFKPIVVDLRQQSFTIEGLAVGVIRNGDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q327W3</accession>
    <name>Q327W3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_4518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327W3"/>
    <dbReference type="EnsemblBacteria" id="ABB64392">
        <property type="protein sequence ID" value="ABB64392"/>
        <property type="gene ID" value="SDY_4518"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4518"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="128" mass="15271" checksum="AB6E9026197E7D9B" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHLISKRYTQRIERHNLNLRQHLARLGRLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q328A4</accession>
    <name>Q328A4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328A4"/>
    <dbReference type="EnsemblBacteria" id="ABB64351">
        <property type="protein sequence ID" value="ABB64351"/>
        <property type="gene ID" value="SDY_4475"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4475"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="9419" checksum="19C36A8DC6671160" modified="2005-12-06" version="1">MAVTVAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITTPRKMLFRAHLILSLTLHQVIFEILHKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q328E9</accession>
    <name>MUTL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mutL</name>
        <name type="ordered locus">SDY_4419</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001122465.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405797.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328E9"/>
    <dbReference type="SMR" id="Q328E9"/>
    <dbReference type="STRING" id="300267.SDY_4419"/>
    <dbReference type="EnsemblBacteria" id="ABB64306">
        <property type="protein sequence ID" value="ABB64306"/>
        <property type="gene ID" value="SDY_4419"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4419"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5217"/>
    <dbReference type="HOGENOM" id="CLU_004131_5_1_6"/>
    <dbReference type="OMA" id="ATQEQAW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000010077" description="DNA mismatch repair protein MutL">
        <location>
            <begin position="1"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="615" mass="67939" checksum="68261F6D7DEAD698" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q328I5</accession>
    <name>Q328I5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">2':3'-cyclic-nucleotide 2'-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cpdB</name>
        <name evidence="10" type="ordered locus">SDY_4383</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19621"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:66949"/>
            <dbReference type="ChEBI" id="CHEBI:66954"/>
            <dbReference type="EC" id="3.1.4.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10144"/>
            <dbReference type="ChEBI" id="CHEBI:13197"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.1.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000388338.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405761.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328I5"/>
    <dbReference type="STRING" id="300267.SDY_4383"/>
    <dbReference type="EnsemblBacteria" id="ABB64270">
        <property type="protein sequence ID" value="ABB64270"/>
        <property type="gene ID" value="SDY_4383"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4383"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5175"/>
    <dbReference type="HOGENOM" id="CLU_005854_4_1_6"/>
    <dbReference type="OMA" id="EKAQYPM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008663">
        <property type="term" value="F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07410">
        <property type="entry name" value="MPP_CpdB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041827">
        <property type="entry name" value="CpdB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006294">
        <property type="entry name" value="Cyc_nuc_PDE_nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01390">
        <property type="entry name" value="CycNucDiestase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005143091" evidence="7">
        <location>
            <begin position="22"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="26"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="9">
        <location>
            <begin position="358"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="649" mass="71104" checksum="0F07249800069412" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q328I7</accession>
    <name>Q328I7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytfG</name>
        <name evidence="2" type="ordered locus">SDY_4382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000560556.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405759.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328I7"/>
    <dbReference type="STRING" id="300267.SDY_4382"/>
    <dbReference type="EnsemblBacteria" id="ABB64269">
        <property type="protein sequence ID" value="ABB64269"/>
        <property type="gene ID" value="SDY_4382"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4382"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5173"/>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_6"/>
    <dbReference type="OMA" id="NGWYHEN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="286" mass="29799" checksum="5CE28EDE4AAAB32A" modified="2005-12-06" version="1">MIAITGATGQLGHYVIESLMETVPASQIVAIVRNPAKALALAAQGITVRQADYGDEAALTSALQGVEKLLLISSSEVGQRAPQHRNVINAAKTAGVKFIAYTSLLHADTSPLGLADEHIETEKMLADSGIVYTLLRNGWYSENYLASAPAALEHGVFIGAAGDGKIASATRADYAAAAARVISEAGHEGKVYELASDSAWTLTQLAAELTKQSGKQVTYQNLSEADFAAALKSVGLPDGLADMLADSDVGASKGGLFDDSKTLSKLIGRPTTTLAESVSHLFNVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q328N0</accession>
    <name>Q328N0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjaB</name>
        <name evidence="2" type="ordered locus">SDY_4333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000236973.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405716.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328N0"/>
    <dbReference type="STRING" id="300267.SDY_4333"/>
    <dbReference type="EnsemblBacteria" id="ABB64225">
        <property type="protein sequence ID" value="ABB64225"/>
        <property type="gene ID" value="SDY_4333"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4333"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5116"/>
    <dbReference type="HOGENOM" id="CLU_013985_21_0_6"/>
    <dbReference type="OMA" id="KIEMLFI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="147" mass="16410" checksum="F7060D8F10933218" modified="2005-12-06" version="1">MVISIRRSRHEEGEELVAIWCRSVDATHDFLSAEYRAELEELVRSFLPEAPLWVAVNERDQPVGFMLLSGQHMDALFIDPDVCGCGVGRMLVEHALSMAPELTTNVNEQNEQAVGFYKKVGFKVTGRSEVDDLGKPYPLLNLAYVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q328W4</accession>
    <name>Q328W4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjdJ</name>
        <name evidence="3" type="ordered locus">SDY_4240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000405647.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405632.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328W4"/>
    <dbReference type="SMR" id="Q328W4"/>
    <dbReference type="STRING" id="300267.SDY_4240"/>
    <dbReference type="EnsemblBacteria" id="ABB64141">
        <property type="protein sequence ID" value="ABB64141"/>
        <property type="gene ID" value="SDY_4240"/>
    </dbReference>
    <dbReference type="GeneID" id="66671962"/>
    <dbReference type="KEGG" id="sdy:SDY_4240"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4994"/>
    <dbReference type="HOGENOM" id="CLU_132888_2_2_6"/>
    <dbReference type="OMA" id="KHEFDTT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="10469" checksum="CA2FC37D117A0B1E" modified="2005-12-06" version="1">MEIREGHNKFYINDEQGKQIAEIVFVPTGENLAIIEHTDVDESLKGQGIGKQLVAKVVEKMRREKRKIIPLCPFAKHEFDKTREYDDIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q328W6</accession>
    <name>Q328W6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">yjdH</name>
        <name evidence="15" type="ordered locus">SDY_4238</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001216477.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405630.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328W6"/>
    <dbReference type="SMR" id="Q328W6"/>
    <dbReference type="STRING" id="300267.SDY_4238"/>
    <dbReference type="EnsemblBacteria" id="ABB64139">
        <property type="protein sequence ID" value="ABB64139"/>
        <property type="gene ID" value="SDY_4238"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4238"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4992"/>
    <dbReference type="HOGENOM" id="CLU_020211_11_2_6"/>
    <dbReference type="OMA" id="HYQNGWL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="346"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB64139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="543" mass="60551" checksum="653C369344CBA238" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q329G5</accession>
    <name>Q329G5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative periplasmic ribose-binding protein of ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378934.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405531.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329G5"/>
    <dbReference type="STRING" id="300267.SDY_4130"/>
    <dbReference type="EnsemblBacteria" id="ABB64040">
        <property type="protein sequence ID" value="ABB64040"/>
        <property type="gene ID" value="SDY_4130"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4130"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4855"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_7_6"/>
    <dbReference type="OMA" id="SVDGGCT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220580" evidence="1">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="30"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="313" mass="32888" checksum="E13F428E0C120344" modified="2005-12-06" version="1">MRLKPLVTALCAGALLAAAPFAQAKELKSIGVTVGDLANPFFVQITKGAELEARKLAGDNVKVTLVSSGYDLGQQVSQIDNFIAANVDMIILNAADSKGIGPAVKRAKDAGIVVVAVDVAAEGADATITSDNTQAGEMACKYITDRLKGKGNVVIINGPPVSAVQNRVEGCQTEFKRHPDIKVLSDNQNAKGSREGGLEVMTRLLAANPKIDGVFAINDPTAIGADLAAKQAQRNEFFIVGVDGSPDAEEALKRENSLFVATPAQDPQVMAAKAVEIGYDILQGKPAPKEPVLIPVTMIDKNNVGNYKGWTVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q329P2</accession>
    <name>GPMI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="1">BPG-independent PGAM</shortName>
            <shortName evidence="1">Phosphoglyceromutase</shortName>
            <shortName evidence="1">iPGM</shortName>
            <ecNumber evidence="1">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmI</name>
        <name type="ordered locus">SDY_4045</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016722.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405454.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329P2"/>
    <dbReference type="SMR" id="Q329P2"/>
    <dbReference type="STRING" id="300267.SDY_4045"/>
    <dbReference type="EnsemblBacteria" id="ABB63963">
        <property type="protein sequence ID" value="ABB63963"/>
        <property type="gene ID" value="SDY_4045"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4045"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4761"/>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_6"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000212203" description="2,3-bisphosphoglycerate-independent phosphoglycerate mutase">
        <location>
            <begin position="1"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="263"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <sequence length="514" mass="56155" checksum="D95B22B591F67A43" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q329R0</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">SDY_4027</name>
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    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405436.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329R0"/>
    <dbReference type="EnsemblBacteria" id="ABB63945">
        <property type="protein sequence ID" value="ABB63945"/>
        <property type="gene ID" value="SDY_4027"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4027"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4741"/>
    <dbReference type="HOGENOM" id="CLU_021517_2_0_6"/>
    <dbReference type="OMA" id="LWEFILD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="553" mass="64001" checksum="5AAB446E8290C162" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q329W1</accession>
    <name>Q329W1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">rho</name>
        <name evidence="11" type="ordered locus">SDY_3966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
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    </dbReference>
    <dbReference type="RefSeq" id="YP_405385.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329W1"/>
    <dbReference type="SMR" id="Q329W1"/>
    <dbReference type="STRING" id="300267.SDY_3966"/>
    <dbReference type="EnsemblBacteria" id="ABB63894">
        <property type="protein sequence ID" value="ABB63894"/>
        <property type="gene ID" value="SDY_3966"/>
    </dbReference>
    <dbReference type="GeneID" id="67414430"/>
    <dbReference type="KEGG" id="sdy:SDY_3966"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4678"/>
    <dbReference type="HOGENOM" id="CLU_016377_4_3_6"/>
    <dbReference type="OMA" id="TRLCRAH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
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        <property type="entry name" value="CSD"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="10">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA-binding 1" evidence="8">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA-binding 1" evidence="8">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA-binding 1" evidence="8">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA-binding 2" evidence="8">
        <location>
            <begin position="284"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="RNA-binding 2" evidence="8">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="419" mass="47004" checksum="5970A85334C43467" modified="2005-12-06" version="1">MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A23</accession>
    <name>Q32A23_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yigZ</name>
        <name evidence="4" type="ordered locus">SDY_3897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405323.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A23"/>
    <dbReference type="STRING" id="300267.SDY_3897"/>
    <dbReference type="EnsemblBacteria" id="ABB63832">
        <property type="protein sequence ID" value="ABB63832"/>
        <property type="gene ID" value="SDY_3897"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3897"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4605"/>
    <dbReference type="HOGENOM" id="CLU_083552_0_0_6"/>
    <dbReference type="OMA" id="VTVDHQR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="142"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="205" mass="21838" checksum="796286366E75AE48" modified="2005-12-06" version="1">MMESWLIPAAPVTVVEEIKKSRFITMLAHTDGVEAAKAFVESVRAEHPDARHHCVAWVAGAPDDSQQLGFSDDGEPAGTAGKPMLAQLMGSGVGEITAVVVRYYGGILLGTGGLVKAYGGGVNQALRQLTTQRKTPLTEYTLQCEYSQLTGIEALLGQCDGKIINSDYQAFVLLRVALPAAKVAEFSAKLADFSRGSLQLLAIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A66</accession>
    <name>Q32A66_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A66"/>
    <dbReference type="EnsemblBacteria" id="ABB63789">
        <property type="protein sequence ID" value="ABB63789"/>
        <property type="gene ID" value="SDY_3846"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3846"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="13074" checksum="AC32D4D9CC16A0EB" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A67</accession>
    <name>RHAM_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-rhamnose mutarotase</fullName>
            <ecNumber evidence="1">5.1.3.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Rhamnose 1-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type-3 mutarotase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhaM</name>
        <name type="ordered locus">SDY_3845</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the anomeric conversion of L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-L-rhamnose = beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:25584"/>
            <dbReference type="ChEBI" id="CHEBI:27586"/>
            <dbReference type="ChEBI" id="CHEBI:27907"/>
            <dbReference type="EC" id="5.1.3.32"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; L-rhamnose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the rhamnose mutarotase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.32" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000619496.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405279.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A67"/>
    <dbReference type="SMR" id="Q32A67"/>
    <dbReference type="STRING" id="300267.SDY_3845"/>
    <dbReference type="EnsemblBacteria" id="ABB63788">
        <property type="protein sequence ID" value="ABB63788"/>
        <property type="gene ID" value="SDY_3845"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3845"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4542"/>
    <dbReference type="HOGENOM" id="CLU_100689_2_0_6"/>
    <dbReference type="OMA" id="KRHDEIW"/>
    <dbReference type="UniPathway" id="UPA00125"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062192">
        <property type="term" value="F:L-rhamnose mutarotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019299">
        <property type="term" value="P:rhamnose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01663">
        <property type="entry name" value="L_rham_rotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013448">
        <property type="entry name" value="L-rhamnose_mutarotase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02625">
        <property type="entry name" value="YiiL_rotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0684">Rhamnose metabolism</keyword>
    <feature type="chain" id="PRO_0000344605" description="L-rhamnose mutarotase">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01663"/>
        </source>
    </evidence>
    <sequence length="104" mass="12293" checksum="799EFC8250EEC7E2" modified="2005-12-06" version="1">MIRKAFVMQVNPDAHEEYQRRHNPIWPELEAVLKSHGAHNYAIYLDKARNLLFAMVEIESEERWNAVASTEICQRWWKYMTDVMPANPDNSPVSSELQEVFYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AA7</accession>
    <name>Q32AA7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator for deo operon, udp, cdd, tsx, nupC, and nupG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cytR</name>
        <name evidence="5" type="ordered locus">SDY_3803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000644910.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405239.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AA7"/>
    <dbReference type="STRING" id="300267.SDY_3803"/>
    <dbReference type="EnsemblBacteria" id="ABB63748">
        <property type="protein sequence ID" value="ABB63748"/>
        <property type="gene ID" value="SDY_3803"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3803"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4493"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_6"/>
    <dbReference type="OMA" id="HSEFVFM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="341" mass="37839" checksum="9649D892408B2E50" modified="2005-12-06" version="1">MKAKKQETAATMKDVALKAKVSTATVSRALMNPDKVSQATRNRVEKAAREVGYLPQPMGRNVKRNESRTILVIVPDICDPFFSEIIRGIEVTAANHGYLVLIGDCAHQNQQEKTFIDLIITKQIDGMLLLGSRLPFDASIEEQRNLPPMVMANEFAPELELPTVHIDNLTAAFDAVNYLYEQGHKRIGCIAGPEEMPLCRYRLQGYVQALRRCGIMVDPQYIARGDFTFEAGSKAMQQLLDLPQPPTAVFCHSDVMALGALSQAKRQGLKVPEDLSIIGFDNIDLTQFCDPPLTTIAQPRYEIGREAMLLLLDQMQGQHVGSGSRLMDCELIIRGSTRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AL6</accession>
    <name>Q32AL6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhgE</name>
        <name evidence="2" type="ordered locus">SDY_3674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AL6"/>
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    <dbReference type="EnsemblBacteria" id="ABB63639">
        <property type="protein sequence ID" value="ABB63639"/>
        <property type="gene ID" value="SDY_3674"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3674"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4360"/>
    <dbReference type="HOGENOM" id="CLU_030637_1_1_6"/>
    <dbReference type="OMA" id="WALWLRI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025291">
        <property type="entry name" value="DUF4153"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13687">
        <property type="entry name" value="DUF4153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="574" mass="64495" checksum="9A5427FF0A1074CD" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AL8</accession>
    <name>Q32AL8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">envZ</name>
        <name evidence="12" type="ordered locus">SDY_3672</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001253696.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405128.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AL8"/>
    <dbReference type="SMR" id="Q32AL8"/>
    <dbReference type="STRING" id="300267.SDY_3672"/>
    <dbReference type="EnsemblBacteria" id="ABB63637">
        <property type="protein sequence ID" value="ABB63637"/>
        <property type="gene ID" value="SDY_3672"/>
    </dbReference>
    <dbReference type="GeneID" id="66672714"/>
    <dbReference type="KEGG" id="sdy:SDY_3672"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4357"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_27_6"/>
    <dbReference type="OMA" id="WIRPPQA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="180"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="240"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="450" mass="50334" checksum="D58444D038722146" modified="2005-12-06" version="1">MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGTTKEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AM4</accession>
    <name>FEOC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable [Fe-S]-dependent transcriptional repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">feoC</name>
        <name type="ordered locus">SDY_3666</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May function as a transcriptional regulator that controls feoABC expression.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FeoC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000157586.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405122.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AM4"/>
    <dbReference type="SMR" id="Q32AM4"/>
    <dbReference type="STRING" id="300267.SDY_3666"/>
    <dbReference type="EnsemblBacteria" id="ABB63631">
        <property type="protein sequence ID" value="ABB63631"/>
        <property type="gene ID" value="SDY_3666"/>
    </dbReference>
    <dbReference type="GeneID" id="66672708"/>
    <dbReference type="KEGG" id="sdy:SDY_3666"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4350"/>
    <dbReference type="HOGENOM" id="CLU_189182_0_0_6"/>
    <dbReference type="OMA" id="CLSGGCK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01586">
        <property type="entry name" value="FeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023732">
        <property type="entry name" value="FeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015102">
        <property type="entry name" value="Tscrpt_reg_HTH_FeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09012">
        <property type="entry name" value="FeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000313069" description="Probable [Fe-S]-dependent transcriptional repressor">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01586"/>
        </source>
    </evidence>
    <sequence length="78" mass="8660" checksum="88976DE22CA9024B" modified="2005-12-06" version="1">MASLIQVRDLLALRGRMEAAQISQTLNTPQPMINAMLQQLESMGKAVRIQEEPDGCLSGSCKSCPEGKACLREWWALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AR1</accession>
    <name>Q32AR1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uncharacterized MFS-type transporter YhhS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">yhhS</name>
        <name evidence="8" type="ordered locus">SDY_3624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. YhhS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AR1"/>
    <dbReference type="STRING" id="300267.SDY_3624"/>
    <dbReference type="EnsemblBacteria" id="ABB63594">
        <property type="protein sequence ID" value="ABB63594"/>
        <property type="gene ID" value="SDY_3624"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3624"/>
    <dbReference type="HOGENOM" id="CLU_001265_10_3_6"/>
    <dbReference type="OMA" id="CAFVGAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01118">
        <property type="entry name" value="MFS_YhhS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023008">
        <property type="entry name" value="MFS_YhhS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="387" mass="40206" checksum="87AAABBDB50D4B17" modified="2005-12-06" version="1">MSPLSCLTSPATSPSGCRSLYYRAMSHDVMGFSAFWAGLVISLQYFATLLSRPHAGRYADLLGPKKIVVFGLCGCFLSGLGYLTAGLTASLPVISLLLLCLGRVILGIGQSFAGTGSTLWGVGVVGSLHIGRVISWNGIVTYGAMAMGAPLGVVFYHWGGLQALALIIMGVALVAILLAIPRPTVKASKGKPLPFRAVLGRVWLYGMALALASAGFGVIATFITLFYDAKGWDGAAFALTLFSCAFVGTRLLFPNGINRIGGLNVAMICFSVEIIGLLLVGVATMPWMAKIGVLLAGAGFSLVFPALGVVAVKAVPQQNQGAALATYTVFMDLSLGVTGPLAGLVMSWAGVPVIYLAAAGLVAIALLLTWRLKKRPPEHVPEAVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AW2</accession>
    <name>Q32AW2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pitA</name>
        <name evidence="8" type="ordered locus">SDY_3569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000902780.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405034.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AW2"/>
    <dbReference type="SMR" id="Q32AW2"/>
    <dbReference type="STRING" id="300267.SDY_3569"/>
    <dbReference type="EnsemblBacteria" id="ABB63543">
        <property type="protein sequence ID" value="ABB63543"/>
        <property type="gene ID" value="SDY_3569"/>
    </dbReference>
    <dbReference type="GeneID" id="66672625"/>
    <dbReference type="KEGG" id="sdy:SDY_3569"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4237"/>
    <dbReference type="HOGENOM" id="CLU_015355_4_0_6"/>
    <dbReference type="OMA" id="GYDITRT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="499" mass="53389" checksum="93D551131C524084" modified="2005-12-06" version="1">MLHLFAGLDLHTGLLLLLALAFVLFYEAINGFHDTANAVATVIYTRAMRSQLAVVMAAVFNFLGVLLGGLSVAYAIVHMLPTDLLLNMGSSHGLAMVFSMLLAAIIWNLGTWYFGLPASSSHTLIGAIIGIGLTNALMTGTSVVDALNIPKVLSIFGSLIVSPIVGLVFAGGLIFLLRRYWSGTKKRARIHLTPAEREKKDGKKKPPFWTRIALILSAIGVAFSHGANDGQKGIGLVMLVLIGVAPAGFVVNMNATGYEITRTRDAINNVEAYFEQHPALLKQATGADQLVPAPEAGATQPAEFHCHPSNTINALNRLKGMLTTDVESYDKLSLDQRSQMRRIMLCVSDTIDKVVKMPGVSADDQRLLKKLKSDMLSTIEYAPVWIIMAVALALGIGTMIGWRRVATTIGEKIGKKGMTYAQGMSAQMTAAVSIGLASYTGMPVSTTHVLSSSVAGTMVVDGGGLQRKTVTSILMAWVFTLPAAVLLSGGLYWLSLQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AW4</accession>
    <name>Q32AW4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">uspA</name>
        <name evidence="4" type="ordered locus">SDY_3567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for resistance to DNA-damaging agents.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000323571.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405032.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AW4"/>
    <dbReference type="SMR" id="Q32AW4"/>
    <dbReference type="STRING" id="300267.SDY_3567"/>
    <dbReference type="EnsemblBacteria" id="ABB63541">
        <property type="protein sequence ID" value="ABB63541"/>
        <property type="gene ID" value="SDY_3567"/>
    </dbReference>
    <dbReference type="GeneID" id="67417129"/>
    <dbReference type="KEGG" id="sdy:SDY_3567"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4235"/>
    <dbReference type="HOGENOM" id="CLU_049301_18_0_6"/>
    <dbReference type="OMA" id="DFWSKIL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="144" mass="16066" checksum="EE3BF2141E44D826" modified="2005-12-06" version="1">MAYKHILIAVDLSPESKVLVEKAVSMARPYNAKVSLIHVDVNYSDLYTGLIDVNLGDMQKRISEETHHALTELSTNAGYPITETLSGSGDLGQVLVDAIKKYDMDLVVCGHHQDFWSKLMSSARQLINTVHVDMLIVPLRDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AY0</accession>
    <name>Q32AY0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">shuX</name>
        <name evidence="1" type="ordered locus">SDY_3550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000020038.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405016.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AY0"/>
    <dbReference type="STRING" id="300267.SDY_3550"/>
    <dbReference type="EnsemblBacteria" id="ABB63525">
        <property type="protein sequence ID" value="ABB63525"/>
        <property type="gene ID" value="SDY_3550"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3550"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4212"/>
    <dbReference type="HOGENOM" id="CLU_106714_0_0_6"/>
    <dbReference type="OMA" id="HSFGSIF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16829">
        <property type="entry name" value="ChuX_HutX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010413">
        <property type="entry name" value="HutX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06228">
        <property type="entry name" value="ChuX_HutX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030840">
        <property type="entry name" value="DUF1008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04108">
        <property type="entry name" value="HutX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="164" mass="18404" checksum="5D8864FF450ED7CC" modified="2005-12-06" version="1">MSHVSLQEFLKTEPDGTLEVVAEQYNTTLLEVVINLPFSTVVPGDKFDTVWDTVCEWGNVTTLVHTADVILEFSGELPSGFHRHDYFNLRGKHGMSGHIKAENCTHIALIERKFMGMDTASILFFNKEGSAMLKIFLGRDDHRQLLSEQVSAFHTLAASLKEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BB0</accession>
    <name>Q32BB0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stringent starvation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sspA</name>
        <name evidence="4" type="ordered locus">SDY_3405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. HSP26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000257290.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404886.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BB0"/>
    <dbReference type="STRING" id="300267.SDY_3405"/>
    <dbReference type="EnsemblBacteria" id="ABB63395">
        <property type="protein sequence ID" value="ABB63395"/>
        <property type="gene ID" value="SDY_3405"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3405"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4063"/>
    <dbReference type="HOGENOM" id="CLU_011226_9_3_6"/>
    <dbReference type="OMA" id="ADHYSHR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03186">
        <property type="entry name" value="GST_C_SspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03059">
        <property type="entry name" value="GST_N_SspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034342">
        <property type="entry name" value="SspA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034341">
        <property type="entry name" value="SspA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="92"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="212" mass="24321" checksum="D793B2F81D31B35F" modified="2005-12-06" version="1">MAVAANKRSVMTLFSGPTDIYSHQVRIVLAEKGVSFEIEHVEKDNPPQDLIDLNPNQSVPTLVDRELTLWESRIIMEYLDERFPHPPLMPVYPVARGESRLYMHRIEKDWYTLMNTIINGSASEADAARKQLREELLAIALVFGQKPYFLSDEFSLVDCYLAPLLWRLPQLGIEFSGPGAKELKGYMTRVFERDSFLASLTEAEREMRLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BD8</accession>
    <name>Q32BD8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yrbF</name>
        <name evidence="5" type="ordered locus">SDY_3376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000438245.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404858.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BD8"/>
    <dbReference type="SMR" id="Q32BD8"/>
    <dbReference type="STRING" id="300267.SDY_3376"/>
    <dbReference type="EnsemblBacteria" id="ABB63367">
        <property type="protein sequence ID" value="ABB63367"/>
        <property type="gene ID" value="SDY_3376"/>
    </dbReference>
    <dbReference type="GeneID" id="67415971"/>
    <dbReference type="KEGG" id="sdy:SDY_3376"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4030"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="PKYLFCD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="269" mass="29097" checksum="742EF8DEDA742CF2" modified="2005-12-06" version="1">MEQSVANLVDMRDVSFTRGNRCIFDNISLTVPRGKITAIMGPSGIGKTTLLRLIGGQIAPDHGEILFDGENIPAMSRSRLYTVRKRMSMLFQSGALFTDMNVFDNVAYPLREHTQLPAPLLHSTVMMKLEAVGLRGAAKLMPSELSGGMARRAALARAIALEPDLIMFDEPFVGQDPITMGVLVKLISELNSALGVTCVVVSHDVPEVLSIADHAWILADKKIVAHGSAQALQANPDPRVRQFLDGIADGPVPFRYPAGDYHADLLPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BM6</accession>
    <name>Q32BM6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Negative regulator of exu regulon, exuT, uxaAC, and uxuB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">exuR</name>
        <name evidence="5" type="ordered locus">SDY_3281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BM6"/>
    <dbReference type="STRING" id="300267.SDY_3281"/>
    <dbReference type="EnsemblBacteria" id="ABB63279">
        <property type="protein sequence ID" value="ABB63279"/>
        <property type="gene ID" value="SDY_3281"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3281"/>
    <dbReference type="HOGENOM" id="CLU_017584_9_5_6"/>
    <dbReference type="OMA" id="TWQEHRK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="263" mass="30355" checksum="F6FE406FE63FF6DD" modified="2005-12-06" version="1">MPGAHMEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQQTADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWPQRSHNPYWKKLHEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRYLFAENPVVHLDTATSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BZ6</accession>
    <name>Q32BZ6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BZ6"/>
    <dbReference type="STRING" id="300267.SDY_3145"/>
    <dbReference type="EnsemblBacteria" id="ABB63159">
        <property type="protein sequence ID" value="ABB63159"/>
        <property type="gene ID" value="SDY_3145"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3145"/>
    <dbReference type="HOGENOM" id="CLU_054732_0_0_6"/>
    <dbReference type="OMA" id="LNFYNVH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="2">
        <location>
            <begin position="90"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="329" mass="35237" checksum="0AF93650294769AF" modified="2005-12-06" version="1">MGLPSGYSAGYSYEYFGGNATYMIIPEIAINLGCVLPYHGSYFAAASLAEPMCCIIGAYHANYHTTQYVYEHRMGVKPGGNIALLACAGPMGIGAIDYAINGGIQPSRVVVVDIDDKRLAQVQKLLPVELAASKGIELVYVNTKGMSDPVQMLRALTGDAGFDDIFVYAAVPAVVEMADELLAEDGCLNFFAGPTDKNFKVPFNFYNVHYNSTHVVSTSGGSTDDMKEAIALSATGQLQPSFMVTHIGGLDAVPETVLNLPDIPGGKKLIYNGVTMPLTAIADFAEKGKTDPLFKELARLVEETHGIWNEQAEKYLLAQFGVDIGEAAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C86</accession>
    <name>LPLT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lysophospholipid transporter LplT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lplT</name>
        <name type="ordered locus">SDY_3052</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000004606.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404560.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C86"/>
    <dbReference type="SMR" id="Q32C86"/>
    <dbReference type="STRING" id="300267.SDY_3052"/>
    <dbReference type="EnsemblBacteria" id="ABB63069">
        <property type="protein sequence ID" value="ABB63069"/>
        <property type="gene ID" value="SDY_3052"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3052"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3657"/>
    <dbReference type="HOGENOM" id="CLU_047399_0_0_6"/>
    <dbReference type="OMA" id="ICFGFNP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051978">
        <property type="term" value="F:lysophospholipid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01585">
        <property type="entry name" value="MFS_LplT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023727">
        <property type="entry name" value="LysoPLipid__transptr_LplT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000309835" description="Lysophospholipid transporter LplT">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="248"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="278"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="365"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01585"/>
        </source>
    </evidence>
    <sequence length="397" mass="41570" checksum="80136BBFAD91B3AE" modified="2005-12-06" version="1">MSESVHTNTSLWSKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQVADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSKLVKANGLMEASTIAAILLGSVAGGVLADWHVLVALAACALAYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWCNGETRFSLVGTSLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVLIFSLQHELLPAYALLMLIGVLGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLGIYSLAVMVGIPVVPIGIGFGALFALAITALWIWQRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C92</accession>
    <name>Q32C92_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoenolpyruvate--protein phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ptsP</name>
        <name evidence="12" type="ordered locus">SDY_3046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000957899.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404554.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C92"/>
    <dbReference type="STRING" id="300267.SDY_3046"/>
    <dbReference type="EnsemblBacteria" id="ABB63063">
        <property type="protein sequence ID" value="ABB63063"/>
        <property type="gene ID" value="SDY_3046"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3046"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3651"/>
    <dbReference type="HOGENOM" id="CLU_007308_7_1_6"/>
    <dbReference type="OMA" id="MFPMISE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAF" evidence="11">
        <location>
            <begin position="17"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="748" mass="83795" checksum="CF95B550AE8022CF" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CC1</accession>
    <name>Q32CC1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sdaB</name>
        <name evidence="12" type="ordered locus">SDY_3014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000626418.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404525.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CC1"/>
    <dbReference type="STRING" id="300267.SDY_3014"/>
    <dbReference type="EnsemblBacteria" id="ABB63034">
        <property type="protein sequence ID" value="ABB63034"/>
        <property type="gene ID" value="SDY_3014"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3014"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3618"/>
    <dbReference type="HOGENOM" id="CLU_022305_0_1_6"/>
    <dbReference type="OMA" id="ELHRDTY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="3"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="184"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="455" mass="48753" checksum="17DB5614A48F2B39" modified="2005-12-06" version="1">MISVFDIFKIGIGPSSSHTVGPMKAGKQFTDDLIARNLLKDVTRVVVDVYGSLSLTGKGHHTDIAIIMGLAGNLPDTVDIDSIPGFIQDVNTHGRLMLANSQHEVEFPVDQCMNFHADNLSLHENGMRITALAGDKVVYSQTYYSIGGGFIVDEEHFGQQDSAPVEVPYPYSSAADLQKHCQETGLSLSGLMMKNELALHSKEELEQHLANVWEVMRGGIERGISTEGVLPGKLRVPRRAAALRRMLVSQDKTTTDPMAVVDWINMFALAVNEENAAGGRVVTAPTNGACGIIPAVLAYYDKFIREVNANSLARYLLVASAIGSLYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGASPAQVCIAAEIAMEHNLGLTCDPVAGQVQVPCIERNAIAAVKAVNAARMALRRTSEPRVCLDKVIETMYETGKDMNAKYRETSRGGLAMKIVACD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CG3</accession>
    <name>CYSJ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfite reductase [NADPH] flavoprotein alpha-component</fullName>
            <shortName evidence="1">SiR-FP</shortName>
            <ecNumber evidence="1">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysJ</name>
        <name type="ordered locus">SDY_2966</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -&gt; FAD -&gt; FMN to the hemoprotein component.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000211931.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404483.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CG3"/>
    <dbReference type="SMR" id="Q32CG3"/>
    <dbReference type="STRING" id="300267.SDY_2966"/>
    <dbReference type="PRIDE" id="Q32CG3"/>
    <dbReference type="EnsemblBacteria" id="ABB62992">
        <property type="protein sequence ID" value="ABB62992"/>
        <property type="gene ID" value="SDY_2966"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2966"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3558"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_7_6"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01541">
        <property type="entry name" value="CysJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010199">
        <property type="entry name" value="CysJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029758">
        <property type="entry name" value="CysJ_Proteobact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000207">
        <property type="entry name" value="SiR-FP_CysJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01931">
        <property type="entry name" value="cysJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000292974" description="Sulfite reductase [NADPH] flavoprotein alpha-component">
        <location>
            <begin position="1"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="64"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="234"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="70"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="386"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="404"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="419"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="519"/>
            <end position="520"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="525"/>
            <end position="529"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01541"/>
        </source>
    </evidence>
    <sequence length="599" mass="66413" checksum="F2BF96DC17A591C6" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CH7</accession>
    <name>Q32CH7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iap</name>
        <name evidence="3" type="ordered locus">SDY_2952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000490453.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404469.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CH7"/>
    <dbReference type="STRING" id="300267.SDY_2952"/>
    <dbReference type="MEROPS" id="M28.005"/>
    <dbReference type="EnsemblBacteria" id="ABB62978">
        <property type="protein sequence ID" value="ABB62978"/>
        <property type="gene ID" value="SDY_2952"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2952"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3544"/>
    <dbReference type="HOGENOM" id="CLU_049425_1_0_6"/>
    <dbReference type="OMA" id="EATNWSL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221009" evidence="1">
        <location>
            <begin position="25"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="100"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="345" mass="37849" checksum="70F6ACA665742D96" modified="2005-12-06" version="1">MFSALRHRTAALALGVCFIPPIHASSPKPGDFANTQARHIATFFPGRMTGTPAEMLSADYIRQQFQQMGYRSDIRTFNSRYIYTARDNRKSWHNVTGSTVIAAHEGKAPQQIIIMAHLDTYAPLSDADADANLGGLTLQGMDDNAAGLGVMLELAERLKNTPTEYGIRFVATSGEEEGKLGAENLLKRMSDTEKKNTLLVINLDNLIVGDKLYFNSGVKTPEAVRKLTRDRALAIARSHGIAATTNPGLNKNYPKGTGCCNDAEIFDKAGIAVLSVEATNWNLGNKDGYQQRAKTAALPAGNSWHDVRLDNQQHIDKALPGRIERRCRDVMRIMLPLVKELAKAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CI5</accession>
    <name>TRUD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase D</fullName>
            <ecNumber evidence="1">5.4.99.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(13) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truD</name>
        <name type="ordered locus">SDY_2944</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(13) in tRNA = pseudouridine(13) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42540"/>
            <dbReference type="Rhea" id="RHEA-COMP:10105"/>
            <dbReference type="Rhea" id="RHEA-COMP:10106"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.27" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000568924.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404461.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CI5"/>
    <dbReference type="SMR" id="Q32CI5"/>
    <dbReference type="STRING" id="300267.SDY_2944"/>
    <dbReference type="EnsemblBacteria" id="ABB62970">
        <property type="protein sequence ID" value="ABB62970"/>
        <property type="gene ID" value="SDY_2944"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2944"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3536"/>
    <dbReference type="HOGENOM" id="CLU_005281_4_0_6"/>
    <dbReference type="OMA" id="LWLWVEK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01082">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043165">
        <property type="entry name" value="TruD_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000230152" description="tRNA pseudouridine synthase D">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="TRUD" evidence="1">
        <location>
            <begin position="155"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01082"/>
        </source>
    </evidence>
    <sequence length="349" mass="39077" checksum="27DE52877418A393" modified="2005-12-06" version="1">MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGALRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQRRVNDKELMITAALPGSGEWGTQREALAFEQAAVAAETELQALLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIRFWLPAGSFATSVVRELINTTGDYAHIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D13</accession>
    <name>Q32D13_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yfhC</name>
        <name evidence="3" type="synonym">tadA</name>
        <name evidence="5" type="ordered locus">SDY_2749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001298403.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404283.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D13"/>
    <dbReference type="STRING" id="300267.SDY_2749"/>
    <dbReference type="EnsemblBacteria" id="ABB62792">
        <property type="protein sequence ID" value="ABB62792"/>
        <property type="gene ID" value="SDY_2749"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2749"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3314"/>
    <dbReference type="HOGENOM" id="CLU_025810_3_0_6"/>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="178" mass="20044" checksum="3BB843A4FD60BA9B" modified="2005-12-06" version="1">MRRAFITGVFFLSEVEFSHEYWMRHAMTLAKRAWDEREVPVGAVLVHNNRVIGEGWNRPIGRHDPTAHAEIMALRQGGLVMQNYRLIDATLYVTLEPCVMCAGAMIHSRIGRVVFGARDAKTGAAGSLMDVLHHPGMNHRVEITEGILADECAALLSDFFRMRRQEIKAQKKAQSSTD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D44</accession>
    <name>NDK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name type="ordered locus">SDY_2714</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000963837.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404252.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D44"/>
    <dbReference type="SMR" id="Q32D44"/>
    <dbReference type="STRING" id="300267.SDY_2714"/>
    <dbReference type="EnsemblBacteria" id="ABB62761">
        <property type="protein sequence ID" value="ABB62761"/>
        <property type="gene ID" value="SDY_2714"/>
    </dbReference>
    <dbReference type="GeneID" id="67416902"/>
    <dbReference type="KEGG" id="sdy:SDY_2714"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3272"/>
    <dbReference type="HOGENOM" id="CLU_060216_8_1_6"/>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000226578" description="Nucleoside diphosphate kinase">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <sequence length="143" mass="15463" checksum="8C069C10043532EC" modified="2005-12-06" version="1">MAIERTFSIIKPNAVAKNVIGNIFARFEAAGFKIVGTKMLHLTVEQARGFYAEHDGKPFFDGLVEFMTSGPIVVSVLEGENAVQRHRDLLGATNPANALAGTLRADYADSLTENGTHGSDSVESAAREIAYFFGEGEVCPRTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DB9</accession>
    <name>YPEA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyltransferase YpeA</fullName>
            <ecNumber evidence="1">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ypeA</name>
        <name type="ordered locus">SDY_2632</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. YpeA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000406000.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404177.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DB9"/>
    <dbReference type="SMR" id="Q32DB9"/>
    <dbReference type="STRING" id="300267.SDY_2632"/>
    <dbReference type="EnsemblBacteria" id="ABB62686">
        <property type="protein sequence ID" value="ABB62686"/>
        <property type="gene ID" value="SDY_2632"/>
    </dbReference>
    <dbReference type="GeneID" id="67416831"/>
    <dbReference type="KEGG" id="sdy:SDY_2632"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3170"/>
    <dbReference type="HOGENOM" id="CLU_013985_34_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01127">
        <property type="entry name" value="Acetyltransf_YpeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023072">
        <property type="entry name" value="Acetyltransferase_YpeA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000298446" description="Acetyltransferase YpeA">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01127"/>
        </source>
    </evidence>
    <sequence length="141" mass="16326" checksum="F0B8B0B23F36267F" modified="2007-08-21" version="2">MEIRVFRQEDFEEVITLWERCDLLRPWNDPEMDIERKMNHDVSLFLVAEVNGEVVGTVMGGYDGHRGSAYYLGVHPEFRGRGIANALLNRLEKKLIARGCPKIQINVPEDNDMVLGMYERLGYEHADVLSLGKRLIEDEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DG5</accession>
    <name>Q32DG5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipid A biosynthesis palmitoleoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.242</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Kdo(2)-lipid IV(A) palmitoleoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ddg</name>
        <name evidence="8" type="synonym">lpxP</name>
        <name evidence="9" type="ordered locus">SDY_2576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(palmitoleoyl)-lipid IV(A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2-&gt;4)-alpha-Kdo-(2-&gt;6)-lipid IVA = (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:44012"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="ChEBI" id="CHEBI:60365"/>
            <dbReference type="ChEBI" id="CHEBI:61520"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="EC" id="2.3.1.242"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.242" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DG5"/>
    <dbReference type="STRING" id="300267.SDY_2576"/>
    <dbReference type="EnsemblBacteria" id="ABB62640">
        <property type="protein sequence ID" value="ABB62640"/>
        <property type="gene ID" value="SDY_2576"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2576"/>
    <dbReference type="HOGENOM" id="CLU_049421_1_0_6"/>
    <dbReference type="OMA" id="FWFHRRF"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008951">
        <property type="term" value="F:palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036104">
        <property type="term" value="P:Kdo2-lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01942">
        <property type="entry name" value="Lipid_A_LpxL_LpxP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01943">
        <property type="entry name" value="Lipid_A_LpxP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011920">
        <property type="entry name" value="Lipid_A_LpxL_LpxP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030857">
        <property type="entry name" value="Lipid_A_LpxP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026649">
        <property type="entry name" value="MsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02207">
        <property type="entry name" value="lipid_A_htrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXXXXD motif" evidence="8">
        <location>
            <begin position="154"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="328" mass="38133" checksum="1A5AD5128D5F2077" modified="2005-12-06" version="1">MSVPLSTWNLLRYNNSYLQKVTMFPQCKFSREFLHPRYWLTWFGLGVLWLWVQLPYPVLCFLGTRIGAMARPFLKRRESIARKNLELCFPQHSAEEREKMIAENFRSLGMALVETGMAWFWPDSRVRKWFDVEGLDNLKRAQMQNRGVMVVGVHFMSLELGGRVMGLCQPMMATYRPHNNQLMEWVQTRGRMRSNKAMIGRNNLRGIVSALKKGEAVWFAPDQDYGRKGSSFAPFFAVENVATTNGTYVLSRLSGAAMLTVTMVRKADYSGYRLFITPEMEGYPTDENQAAAYMNKIIEKEIMRAPEQYLWIHRRFKTRPVGESSLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DV1</accession>
    <name>Q32DV1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">pH-inducible stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">inaA</name>
        <name evidence="1" type="ordered locus">SDY_2431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DV1"/>
    <dbReference type="STRING" id="300267.SDY_2431"/>
    <dbReference type="EnsemblBacteria" id="ABB62504">
        <property type="protein sequence ID" value="ABB62504"/>
        <property type="gene ID" value="SDY_2431"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2431"/>
    <dbReference type="HOGENOM" id="CLU_094468_0_0_6"/>
    <dbReference type="OMA" id="WVEEPNQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="186" mass="21619" checksum="C884B9B3D7D6C76C" modified="2005-12-06" version="1">MSGVQCVERNGKKLYVKRMTHHLFHSVRYPFGRPTIVREVAVIKELERAGVIVPKIVFGEAVKIEGEWRALLVTEDMAGFISIADWYAQHAVTPYSDEVRQAMLKAVALAFKKMHSVNRQHGCCYVRHIYVKTEGKAEAGFLDLEKSRRRLRRHKAINHDFRQLEKYLEPIPKADWGQVKAYYYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DV5</accession>
    <name>Q32DV5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_2427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DV5"/>
    <dbReference type="STRING" id="300267.SDY_2427"/>
    <dbReference type="EnsemblBacteria" id="ABB62500">
        <property type="protein sequence ID" value="ABB62500"/>
        <property type="gene ID" value="SDY_2427"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2427"/>
    <dbReference type="HOGENOM" id="CLU_067055_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003368">
        <property type="entry name" value="POMP_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02415">
        <property type="entry name" value="Chlam_PMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01376">
        <property type="entry name" value="POMP_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="176" mass="18391" checksum="7B378C6F8522E0FF" modified="2005-12-06" version="1">MIASLFSANGVAAAIDLCQGYDIKASCHASRQSLSGITQVWSIADGQWLVFSDMTNNASGGAVFLQQGAEFTLSPENETGMTLFANNTVSGEYNNGGAIFAKENSTLNLTDVIFSGNVAGGYGGAIYSSGTNDTGAIDLRVTNAVFRNNIANDGKGGAIYTINNDIYLSDDVFNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E05</accession>
    <name>Q32E05_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding component of cytochrome-related transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cydC</name>
        <name evidence="10" type="ordered locus">SDY_2375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001202234.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403941.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E05"/>
    <dbReference type="STRING" id="300267.SDY_2375"/>
    <dbReference type="EnsemblBacteria" id="ABB62450">
        <property type="protein sequence ID" value="ABB62450"/>
        <property type="gene ID" value="SDY_2375"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2375"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2869"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_6"/>
    <dbReference type="OMA" id="VYQEIYY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014223">
        <property type="entry name" value="ABC_CydC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02868">
        <property type="entry name" value="CydC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="339"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="573" mass="62907" checksum="7F11A7BDE7B48804" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E35</accession>
    <name>LPXK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tetraacyldisaccharide 4'-kinase</fullName>
            <ecNumber evidence="1">2.7.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid A 4'-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxK</name>
        <name type="ordered locus">SDY_2343</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-beta-D-glucosaminyl}-(1-&gt;6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate} = ADP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-beta-D-glucosaminyl}-(1-&gt;6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate}.</text>
            <dbReference type="EC" id="2.7.1.130"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LpxK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.130" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000570528.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403911.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E35"/>
    <dbReference type="SMR" id="Q32E35"/>
    <dbReference type="STRING" id="300267.SDY_2343"/>
    <dbReference type="EnsemblBacteria" id="ABB62420">
        <property type="protein sequence ID" value="ABB62420"/>
        <property type="gene ID" value="SDY_2343"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2343"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2827"/>
    <dbReference type="HOGENOM" id="CLU_038816_2_0_6"/>
    <dbReference type="OMA" id="MDDGFQN"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009029">
        <property type="term" value="F:tetraacyldisaccharide 4'-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00409">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003758">
        <property type="entry name" value="LpxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42724">
        <property type="entry name" value="PTHR42724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02606">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00682">
        <property type="entry name" value="lpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000229981" description="Tetraacyldisaccharide 4'-kinase">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00409"/>
        </source>
    </evidence>
    <sequence length="328" mass="35554" checksum="44B6F79356F10400" modified="2005-12-06" version="1">MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPVPVVVVGNLTAGGNGKTPVVVWLVEQLQQRGIRVGVVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTDAPVAVSPVRSDAVKAILAQHPDVQIIVTDDGLQHYCLARDVEIVVIDGVRRFGNGWWLPAGPMRERAGRLKSIDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVAMAGIGHPPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSTGQTLVMTEKDAVKCWAFAEENWWYLPVDAQLSGDEPAKLLAQLTSLASGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E47</accession>
    <name>Q32E47_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycbK</name>
        <name evidence="1" type="ordered locus">SDY_2331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295932.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403899.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E47"/>
    <dbReference type="STRING" id="300267.SDY_2331"/>
    <dbReference type="EnsemblBacteria" id="ABB62408">
        <property type="protein sequence ID" value="ABB62408"/>
        <property type="gene ID" value="SDY_2331"/>
    </dbReference>
    <dbReference type="GeneID" id="66670798"/>
    <dbReference type="KEGG" id="sdy:SDY_2331"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2814"/>
    <dbReference type="HOGENOM" id="CLU_080400_1_2_6"/>
    <dbReference type="OMA" id="KSYHMKG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010275">
        <property type="entry name" value="DUF882"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37425">
        <property type="entry name" value="PTHR37425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05951">
        <property type="entry name" value="Peptidase_M15_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="182" mass="20354" checksum="2900C1C707F81483" modified="2005-12-06" version="1">MDKFDANRRKLLALGGVALGAAILPTPAFATLSTPRPRILTLNNLHTGESIKAEFFDGRGYIQEELAKLNHFFRDYRANKIKSIDPGLFDQLYRLQGLLGTRKPVQLISGYRSIDTNNELRARSRGVAKKSYHTKGQAMDFHIEGIALSNIRKAALSMRAGGVGYYPRSNFVHIDTGPARHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E58</accession>
    <name>Q32E58_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PBPb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ycbO</name>
        <name evidence="6" type="ordered locus">SDY_2320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021579.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403888.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E58"/>
    <dbReference type="STRING" id="300267.SDY_2320"/>
    <dbReference type="EnsemblBacteria" id="ABB62397">
        <property type="protein sequence ID" value="ABB62397"/>
        <property type="gene ID" value="SDY_2320"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2320"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2800"/>
    <dbReference type="HOGENOM" id="CLU_028871_2_0_6"/>
    <dbReference type="OMA" id="KTADFQY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221060" description="PBPb domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="28"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="330" mass="35875" checksum="7DADFC4DADB9CF1A" modified="2005-12-06" version="1">MRNIIKLALVGLLSVSTLAVAAESSPEALRIGYQKSNISSVLAKNYQMLEKRYPQTKISWGKFPAGPQMLEALNVGSIDLGSTGDIPPIFSQAAGADLLYVSVEPPKPKAEVILVAENSPIKTVADLKGHKVAFQKGSSSHNLLLRALRQAGLKFTDIQPTYLTPADARAAFQQGNVDAWAIWDPYYSAALLQGGVRVLKDGTDLNQTGSFYLAARPYAEKNGAFIQGVLATFSEADALTRSQREQSIALLAKTMGLPAPVIASYLDHRPPTTIKPVNAEVAALQQQTADLFYENRLVPKKVDINASGSPLNWKENNYESEYVLVFTDPW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EB4</accession>
    <name>YEGS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable lipid kinase YegS</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yegS</name>
        <name type="ordered locus">SDY_2261</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably phosphorylates lipids; the in vivo substrate is unknown.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. Ca(2+) may be able to substitute.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000807364.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403832.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EB4"/>
    <dbReference type="SMR" id="Q32EB4"/>
    <dbReference type="STRING" id="300267.SDY_2261"/>
    <dbReference type="EnsemblBacteria" id="ABB62341">
        <property type="protein sequence ID" value="ABB62341"/>
        <property type="gene ID" value="SDY_2261"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2261"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2730"/>
    <dbReference type="HOGENOM" id="CLU_045532_1_1_6"/>
    <dbReference type="OMA" id="GFDSRVN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01377">
        <property type="entry name" value="YegS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022433">
        <property type="entry name" value="Lip_kinase_YegS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03702">
        <property type="entry name" value="lip_kinase_YegS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000292159" description="Probable lipid kinase YegS">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="66"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01377"/>
        </source>
    </evidence>
    <sequence length="299" mass="31974" checksum="7E033BA201D5CB56" modified="2005-12-06" version="1">MAEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIQCEGDDIPALGILPLGTANDFATSVGIPEALDKALKLAIAGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGGVSYIIHGLMRMDTLQPDRCEIRGENFHWQGDGLVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEILPALVSTLKSDEDNPNIIEGASSWFDIQAPHEITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EJ3</accession>
    <name>Q32EJ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EJ3"/>
    <dbReference type="STRING" id="300267.SDY_2176"/>
    <dbReference type="EnsemblBacteria" id="ABB62262">
        <property type="protein sequence ID" value="ABB62262"/>
        <property type="gene ID" value="SDY_2176"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2176"/>
    <dbReference type="HOGENOM" id="CLU_018531_1_0_6"/>
    <dbReference type="OMA" id="YHAGNDS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="535" mass="60658" checksum="79723F3A9AA807A3" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F38</accession>
    <name>MNTP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable manganese efflux pump MntP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mntP</name>
        <name type="synonym">yebN</name>
        <name type="ordered locus">SDY_1967</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably functions as a manganese efflux pump.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MntP (TC 9.B.29) family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62067" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62067.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001296134.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403558.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F38"/>
    <dbReference type="STRING" id="300267.SDY_1967"/>
    <dbReference type="EnsemblBacteria" id="ABB62067">
        <property type="protein sequence ID" value="ABB62067"/>
        <property type="gene ID" value="SDY_1967"/>
    </dbReference>
    <dbReference type="GeneID" id="66674290"/>
    <dbReference type="KEGG" id="sdy:SDY_1967"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2375"/>
    <dbReference type="HOGENOM" id="CLU_096410_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01521">
        <property type="entry name" value="MntP_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022929">
        <property type="entry name" value="Put_MntP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000292544" description="Probable manganese efflux pump MntP">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="188" mass="20117" checksum="09BBB5C3D6185A9B" modified="2007-06-26" version="2">MNITATVLLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAVETLTPLIGWGMGMLASRFVLEWNHWIAFVLLIFLGGRMIIEGFRGADDEDEEPRRRHGFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMVGRFIGSIIGKKAEILGGLVLIGIGVQILWTHFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F66</accession>
    <name>Q32F66_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage Kil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403530.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F66"/>
    <dbReference type="EnsemblBacteria" id="ABB62039">
        <property type="protein sequence ID" value="ABB62039"/>
        <property type="gene ID" value="SDY_1933"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1933"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2329"/>
    <dbReference type="HOGENOM" id="CLU_160564_3_0_6"/>
    <dbReference type="OMA" id="MMALHEG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="55" mass="6118" checksum="D6D2BFAEC2E0A7C0" modified="2005-12-06" version="1">MAKFSVPLHNGRYYMASANVNNALYAHSLIEKIRIISDAIEVYLNNKGQPLISPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FA3</accession>
    <name>Q32FA3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FA3"/>
    <dbReference type="STRING" id="300267.SDY_1896"/>
    <dbReference type="EnsemblBacteria" id="ABB62002">
        <property type="protein sequence ID" value="ABB62002"/>
        <property type="gene ID" value="SDY_1896"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1896"/>
    <dbReference type="HOGENOM" id="CLU_060526_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="385" mass="43912" checksum="0F8AFCCF134FC57A" modified="2005-12-06" version="1">MAVYESCQVTDLQITNAGVMLATNQDLPSETFDLAVIATGHVWPDEEEAIRTYFPSPWSGLMEAKVDACNVGIMGTSLSGLDAAMAVAIQHGSFIEDDKQHVVFHRDNASEKLNITLMSRTGILPEADFYCPIPYEPLHIVTDQALNAEIQKVEYGLLDQVFRLIVEEIKFADPDWSQRIALESLNVDSFAQAWFAERKQRDPFDWAEKNLQEVERNKREKHTVPWRYVILRLHEAVQEIVPHLNEHDHKRFSKGLARVFIDNYAAIPSESIRRLLALREAGIIHILALGEDYKMEINESRTVLKTEDNSYSFDVFIDARGQRPLKVKDLPFPGLREQLQKTGDEIPDVGEDYTLQQPEDIRGRVALVNARPAFRSGTYGMCRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FD1</accession>
    <name>Q32FD1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcriptional regulator SlyA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">slyA</name>
        <name evidence="3" type="ordered locus">SDY_1865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription regulator that can specifically activate or repress expression of target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FD1"/>
    <dbReference type="STRING" id="300267.SDY_1865"/>
    <dbReference type="EnsemblBacteria" id="ABB61974">
        <property type="protein sequence ID" value="ABB61974"/>
        <property type="gene ID" value="SDY_1865"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1865"/>
    <dbReference type="HOGENOM" id="CLU_083287_18_2_6"/>
    <dbReference type="OMA" id="CSNDRRA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01819">
        <property type="entry name" value="HTH_type_SlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023071">
        <property type="entry name" value="Tscrpt_reg_SlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="146" mass="16594" checksum="B166BC6DFADECDCF" modified="2005-12-06" version="1">MKLESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLITLIAKLEHNIIELQAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FF5</accession>
    <name>Q32FF5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Repressor of malX and Y genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">malI</name>
        <name evidence="5" type="ordered locus">SDY_1841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000179522.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403441.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FF5"/>
    <dbReference type="STRING" id="300267.SDY_1841"/>
    <dbReference type="EnsemblBacteria" id="ABB61950">
        <property type="protein sequence ID" value="ABB61950"/>
        <property type="gene ID" value="SDY_1841"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1841"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2220"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_6"/>
    <dbReference type="OMA" id="DGLIFCS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="342" mass="36655" checksum="18C387038D96861E" modified="2005-12-06" version="1">MATAKKITIHDVALAAGVSVSTVSLVLSGKGRISTATGERVNAAIEELGFVRNRQASALRGGQSGVIGLIVRDLSAPFYAELTAGLTEALEAQGRMVFLLHVGKDGEQLAQRFSLLLNQGVDGVVIAGAAGSSDDLRRMAEEKAIPVIFASRASYLDDVDTVRPDNMQAAQLLTEHLIRNGHQRIAWLGGQSSSLTRAERVGGYCATLLKFGLPFHSDWVLECTSSQKQAAEAITALLRHNPTISAVVCYNETIAMGAWFGLLKAGRQSGESGVDRYFEQQVSLAAFTDATPTTLDDIPVTWASTPARELGTTLADRMMQKITHEETHSRNLIIPARLIAAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FI2</accession>
    <name>RL35_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmI</name>
        <name type="ordered locus">SDY_1812</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001124225.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403414.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FI2"/>
    <dbReference type="SMR" id="Q32FI2"/>
    <dbReference type="STRING" id="300267.SDY_1812"/>
    <dbReference type="EnsemblBacteria" id="ABB61923">
        <property type="protein sequence ID" value="ABB61923"/>
        <property type="gene ID" value="SDY_1812"/>
    </dbReference>
    <dbReference type="GeneID" id="64336986"/>
    <dbReference type="GeneID" id="67415577"/>
    <dbReference type="KEGG" id="sdy:SDY_1812"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2183"/>
    <dbReference type="HOGENOM" id="CLU_169643_1_1_6"/>
    <dbReference type="OMA" id="PKIKTHR"/>
    <dbReference type="PRO" id="PR:Q32FI2"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000258752" description="50S ribosomal protein L35">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="65" mass="7289" checksum="98A72C0AD6CE0A07" modified="2005-12-06" version="1">MPKIKTVRGAAKRFKKTGKGGFKHKHANLRHILTKKATKRKRHLRPKAMVSKGDLGLVIACLPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FP0</accession>
    <name>Q32FP0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tellurite resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tehA</name>
        <name evidence="8" type="ordered locus">SDY_1748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022519.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403356.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FP0"/>
    <dbReference type="STRING" id="300267.SDY_1748"/>
    <dbReference type="EnsemblBacteria" id="ABB61865">
        <property type="protein sequence ID" value="ABB61865"/>
        <property type="gene ID" value="SDY_1748"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1748"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2107"/>
    <dbReference type="HOGENOM" id="CLU_044414_1_0_6"/>
    <dbReference type="OMA" id="EVRAEYH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09324">
        <property type="entry name" value="TDT_TehA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039264">
        <property type="entry name" value="TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011552">
        <property type="entry name" value="TehA/Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00816">
        <property type="entry name" value="tdt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="326" mass="35552" checksum="9B9B1E6887D99629" modified="2005-12-06" version="1">MQSDKVLNLPAGYFGIVLGTIGMGFAWRYASQVWQVSHWLGDGLVILAMIIWGLLTSAFITRLIRFPHSVLAEVRHPVLSSFVSLFPATTMLVAIGFVPWFRPLAVCLFSFGVVVQLAYAAWQTAGLWRGSHPEEATTPGLYLPTVANNFISAMACGALGYTDAGLVFLGAGVFSWLSLEPVILQRLRSSGELPTALRTSLGIQLAPALVACSAWLSVNGGEGDTLVKMLFGYGLLQLLFMLRLMPWYLSQPFNASFWSVSALATTGLHLGSGSDNGFFHTLAVPLFIFTNFIIAILLIRTFALLMQGKLLVRTERAVLMKAEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GA6</accession>
    <name>Q32GA6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GA6"/>
    <dbReference type="EnsemblBacteria" id="ABB61649">
        <property type="protein sequence ID" value="ABB61649"/>
        <property type="gene ID" value="SDY_1511"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1511"/>
    <dbReference type="HOGENOM" id="CLU_2144133_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="12924" checksum="4BEC7FE591AE6476" modified="2005-12-06" version="1">MTVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITEYFSHPGWFCNKTFFITFPVITYFRGDNFIHAKKYPTNFHDPLDISEYDSNSTKDSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GL8</accession>
    <name>Q32GL8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403028.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GL8"/>
    <dbReference type="EnsemblBacteria" id="ABB61537">
        <property type="protein sequence ID" value="ABB61537"/>
        <property type="gene ID" value="SDY_1392"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1392"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1653"/>
    <dbReference type="HOGENOM" id="CLU_1765129_0_0_6"/>
    <dbReference type="OMA" id="CCIFFWV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008544">
        <property type="entry name" value="DUF826"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05696">
        <property type="entry name" value="DUF826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="14404" checksum="C9EDC833FF297F86" modified="2005-12-06" version="1">MCCIFFWVGTGLCAISGAGRLIKGPLRKSAPVSQPEANPKSPLLLNNPFQRENPMSEITSLVTAEAVKEVLRSEEVRSALKQKLRQNLESRLDAEVDAILDELLGVPAVPEPEGIAGDGSASDGGEPTPDSDMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GM2</accession>
    <name>Q32GM2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GM2"/>
    <dbReference type="STRING" id="300267.SDY_1388"/>
    <dbReference type="EnsemblBacteria" id="ABB61533">
        <property type="protein sequence ID" value="ABB61533"/>
        <property type="gene ID" value="SDY_1388"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1388"/>
    <dbReference type="HOGENOM" id="CLU_027402_41_1_6"/>
    <dbReference type="OMA" id="NIGCHYY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="144" mass="16963" checksum="C2CFBD232C0F909A" modified="2005-12-06" version="1">MTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSTYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GM5</accession>
    <name>Q32GM5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403021.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GM5"/>
    <dbReference type="STRING" id="300267.SDY_1385"/>
    <dbReference type="EnsemblBacteria" id="ABB61530">
        <property type="protein sequence ID" value="ABB61530"/>
        <property type="gene ID" value="SDY_1385"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1385"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1645"/>
    <dbReference type="HOGENOM" id="CLU_118347_0_0_6"/>
    <dbReference type="OMA" id="MEQIAPE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="164" mass="17144" checksum="34DC5C57F827FE65" modified="2005-12-06" version="1">MEQIAPEAGQNSPDTQQNGPEEQQPAPVAQPELEKNCRVCGQTGGGNCPDCSAVMGDSTYTETFGENDAADGEDSAQTEEKIIQENSVDAAQEGETVVQNEPGSDTSGDDANSEPVTLDWKRQLVIAAVYGLCANPACIATAPAIPDIAIMIANRLENFGGDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GP2</accession>
    <name>Q32GP2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="8">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fabI</name>
        <name evidence="13" type="ordered locus">SDY_1368</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000506494.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403004.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GP2"/>
    <dbReference type="STRING" id="300267.SDY_1368"/>
    <dbReference type="EnsemblBacteria" id="ABB61513">
        <property type="protein sequence ID" value="ABB61513"/>
        <property type="gene ID" value="SDY_1368"/>
    </dbReference>
    <dbReference type="GeneID" id="60900456"/>
    <dbReference type="KEGG" id="sdy:SDY_1368"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1621"/>
    <dbReference type="HOGENOM" id="CLU_010194_10_1_6"/>
    <dbReference type="OMA" id="GILDMIH"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Involved in acyl-ACP binding" evidence="12">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="site" description="Involved in acyl-ACP binding" evidence="12">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="site" description="Involved in acyl-ACP binding" evidence="12">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB61513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="262" mass="27863" checksum="4E002EC25C3ADFA4" modified="2005-12-06" version="1">MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSNIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNELELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GX0</accession>
    <name>Q32GX0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 5">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">galU</name>
        <name evidence="7" type="ordered locus">SDY_1288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000718995.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402926.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GX0"/>
    <dbReference type="SMR" id="Q32GX0"/>
    <dbReference type="STRING" id="300267.SDY_1288"/>
    <dbReference type="EnsemblBacteria" id="ABB61435">
        <property type="protein sequence ID" value="ABB61435"/>
        <property type="gene ID" value="SDY_1288"/>
    </dbReference>
    <dbReference type="GeneID" id="66674942"/>
    <dbReference type="KEGG" id="sdy:SDY_1288"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1527"/>
    <dbReference type="HOGENOM" id="CLU_029499_1_1_6"/>
    <dbReference type="OMA" id="KRYDVGN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="302" mass="32942" checksum="ADEAEB3F6A1194CB" modified="2005-12-06" version="1">MAAINTKVKKAVIPVAGLGTRMLPATKAIPKEMLPLVDKPLIQYVVNECIAAGITEIVLVTHSSKNSIENHFDTSFELEAMLEKRVKRQLLDEVQSICPPHVTIMQVRQGLAKGLGHAVLCAHPVVGDEPVAVILPDVILDEYESDLSQDNLAEMIRRFDETGHSQIMVEPVADVTAYGVVDCKGVELAPGESVPMVGVVEKPKADVAPSNLAIVGRYVLSADIWPLLAKTPPGAGDEIQLTDAIDMLIEKETVEAYHMKGKSHDCGNKLGYMQAFVEYGIRHNTLGTEFKAWLEEEMGIKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GZ8</accession>
    <name>LOLB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Outer-membrane lipoprotein LolB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lolB</name>
        <name type="ordered locus">SDY_1258</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LolB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001130688.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402898.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GZ8"/>
    <dbReference type="SMR" id="Q32GZ8"/>
    <dbReference type="STRING" id="300267.SDY_1258"/>
    <dbReference type="EnsemblBacteria" id="ABB61407">
        <property type="protein sequence ID" value="ABB61407"/>
        <property type="gene ID" value="SDY_1258"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1258"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1495"/>
    <dbReference type="HOGENOM" id="CLU_092816_1_1_6"/>
    <dbReference type="OMA" id="YQTRGSF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044874">
        <property type="term" value="P:lipoprotein localization to outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16326">
        <property type="entry name" value="LolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00233">
        <property type="entry name" value="LolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004565">
        <property type="entry name" value="OM_lipoprot_LolB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03550">
        <property type="entry name" value="LolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00548">
        <property type="entry name" value="lolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_1000021686" description="Outer-membrane lipoprotein LolB">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00233"/>
        </source>
    </evidence>
    <sequence length="207" mass="23597" checksum="C5115A8DF53B8551" modified="2005-12-06" version="1" precursor="true">MPLPDFRLIRLLPLAALVLTACSVTTPKGPGKSPDSPQWRQHQQDVRNLNQYQTRGAFAYISDQQKVYARFFWQQTGQDRYRLLLTNPLGSTELELNAQPGNVQLVDNKGQRYTADDAEEMIGKLTGMPIPLNSLRQWILGLPGDATDYKLDDQYRLSEITYSQNGKNWKVVYCGYDTKTQPAMPANMELTDGGQRIKLKMDNWIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H15</accession>
    <name>Q32H15_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402881.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H15"/>
    <dbReference type="STRING" id="300267.SDY_1239"/>
    <dbReference type="EnsemblBacteria" id="ABB61390">
        <property type="protein sequence ID" value="ABB61390"/>
        <property type="gene ID" value="SDY_1239"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1239"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1470"/>
    <dbReference type="HOGENOM" id="CLU_1863813_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="61"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="137" mass="15470" checksum="80B27BAB8497E83C" modified="2005-12-06" version="1">MLIDDIDFADLYLQQLKLAHRTEKTPDHWDQRAEKMAENCASPTNSYLQQLIAKIDLQGAQTLFDMGCGPGTVSLALADKLTTIYGVDYSQGMLNVAARRAAALKADNVHWIQRAWEEDWSDLPRVMLPISRTCVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H32</accession>
    <name>Q32H32_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
            <ecNumber evidence="3">2.7.7.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">umuC</name>
        <name evidence="8" type="ordered locus">SDY_1221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24898"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="2.7.7.65"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000457640.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402864.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H32"/>
    <dbReference type="STRING" id="300267.SDY_1221"/>
    <dbReference type="EnsemblBacteria" id="ABB61373">
        <property type="protein sequence ID" value="ABB61373"/>
        <property type="gene ID" value="SDY_1221"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1221"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1449"/>
    <dbReference type="HOGENOM" id="CLU_012348_3_0_6"/>
    <dbReference type="OMA" id="YRYEPHR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025188">
        <property type="entry name" value="DUF4113"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13438">
        <property type="entry name" value="DUF4113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0741">SOS mutagenesis</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="UmuC" evidence="7">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="419" mass="47331" checksum="3DBB8FBD1A6D441E" modified="2005-12-06" version="1">MFALCDVNAFYASCETVFRPDLWGVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKDLFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGSAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALPVDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEFAPTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALNEPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQVGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLRVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H45</accession>
    <name>MINC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable septum site-determining protein MinC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">minC</name>
        <name type="ordered locus">SDY_1207</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with MinD and FtsZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MinC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000072536.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402851.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H45"/>
    <dbReference type="SMR" id="Q32H45"/>
    <dbReference type="STRING" id="300267.SDY_1207"/>
    <dbReference type="EnsemblBacteria" id="ABB61360">
        <property type="protein sequence ID" value="ABB61360"/>
        <property type="gene ID" value="SDY_1207"/>
    </dbReference>
    <dbReference type="GeneID" id="66675004"/>
    <dbReference type="KEGG" id="sdy:SDY_1207"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1430"/>
    <dbReference type="HOGENOM" id="CLU_067812_0_1_6"/>
    <dbReference type="OMA" id="RRDPLWG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901891">
        <property type="term" value="P:regulation of cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00267">
        <property type="entry name" value="MinC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013033">
        <property type="entry name" value="MinC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036145">
        <property type="entry name" value="MinC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007874">
        <property type="entry name" value="MinC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005526">
        <property type="entry name" value="Septum_form_inhib_MinC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34108">
        <property type="entry name" value="PTHR34108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03775">
        <property type="entry name" value="MinC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05209">
        <property type="entry name" value="MinC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63848">
        <property type="entry name" value="SSF63848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01222">
        <property type="entry name" value="minC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_1000047866" description="Probable septum site-determining protein MinC">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="231" mass="24745" checksum="ED582F6AD850CFD0" modified="2005-12-06" version="1">MSNTPIELKGSSFTLSVVHLHEAEPKVIHQALEDKIAQAPAFLKHAPVVLNVSALEDPVNWSAMHKAVSATGLRVIGVSGCKDAQLKAEIEKMGLPILTEGKEKAPRPAPAPQAPAQNTTPVTKTRLIDTPVRSGQRIYAPQCDLIVTSHVSAGAELIADGNIHVYGMMRGRALAGASGDRETQIFCTNLMAELVSIAGEYWLSDQIPAEFYGKAARLQLVENALTVQPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H59</accession>
    <name>Q32H59_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yecG</name>
        <name evidence="4" type="ordered locus">SDY_1192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for resistance to DNA-damaging agents.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000122432.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402837.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H59"/>
    <dbReference type="SMR" id="Q32H59"/>
    <dbReference type="STRING" id="300267.SDY_1192"/>
    <dbReference type="EnsemblBacteria" id="ABB61346">
        <property type="protein sequence ID" value="ABB61346"/>
        <property type="gene ID" value="SDY_1192"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1192"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1411"/>
    <dbReference type="HOGENOM" id="CLU_049301_18_1_6"/>
    <dbReference type="OMA" id="CGNHNQS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="142" mass="15669" checksum="956EECF2745A7AFC" modified="2005-12-06" version="1">MSYSNILVAVAVTPESQQLLAKAVSIARPVKGHISLITLASDPEMYNQLAAPMLEDLRSVMQEETQSFLDKLIQDAGYPVDKTFIAYGELSEHILEVCRKYHFDLVICGNHNHSFFSRASCSAKRVIASSEVDVLLVPLTGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HC7</accession>
    <name>ARAG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arabinose import ATP-binding protein AraG</fullName>
            <ecNumber evidence="1">7.5.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">araG</name>
        <name type="ordered locus">SDY_1121</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-arabinose(out) = ADP + H(+) + L-arabinose(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30007"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17535"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.5.2.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (AraG), two transmembrane proteins (AraH) and a solute-binding protein (AraF).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001187828.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402769.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HC7"/>
    <dbReference type="SMR" id="Q32HC7"/>
    <dbReference type="STRING" id="300267.SDY_1121"/>
    <dbReference type="EnsemblBacteria" id="ABB61278">
        <property type="protein sequence ID" value="ABB61278"/>
        <property type="gene ID" value="SDY_1121"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1121"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1321"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_6"/>
    <dbReference type="OMA" id="NVHLGHE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015612">
        <property type="term" value="F:ABC-type L-arabinose transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042882">
        <property type="term" value="P:L-arabinose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017917">
        <property type="entry name" value="ABC_transptr_Ara_ATP-bd_AraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF6">
        <property type="entry name" value="PTHR43790:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51268">
        <property type="entry name" value="ARAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000270479" description="Arabinose import ATP-binding protein AraG">
        <location>
            <begin position="1"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="1">
        <location>
            <begin position="256"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01721"/>
        </source>
    </evidence>
    <sequence length="504" mass="55046" checksum="0EB25F091E4229D7" modified="2005-12-06" version="1">MQQSTPYLSFRGIGKTFPGVKALTDISFDCYAGQVHALMGENGAGKSTLLKILSGNYAPTTGSVVINGQEMSFSDTTAALNAGVAIIYQELHLVPEMTVAENIYLGQLPHKGGIVNRSLLNYEAGLQLKHLGMDIDPDTPLKYLSIGQWQMVEIAKALARNAKIIAFDEPTSSLSAREIDNLFRVIRELRKEGRVILYVSHRMEEIFALSDAITVFKDGRYVRTFTDMQQVDHDALVQAMVGRDIGDIYGWQPRSYGEERLRLDAVKAPGVRTPISLAVRSGEIVGLFGLVGAGRSELMKGMFGGTQITAGQVYIDQQPIDIRKPSHAIAAGMMLCPEDRKAEGIIPVHSVRDNINISARRKHVLGGCVINNGWEENNADHHIRSLNIKTPGAEQLIMNLSGGNQQKAILGRWLSEEMKVILLDEPTRGIDVGAKHEIYNVIYALAAQGVAVLFASSDLPEVLGVADRIVVMREGEIAGELLHEQADERQALSLAMPKVSQAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HD8</accession>
    <name>Q32HD8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yecA</name>
        <name evidence="1" type="ordered locus">SDY_1110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000847882.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402758.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HD8"/>
    <dbReference type="SMR" id="Q32HD8"/>
    <dbReference type="STRING" id="300267.SDY_1110"/>
    <dbReference type="EnsemblBacteria" id="ABB61267">
        <property type="protein sequence ID" value="ABB61267"/>
        <property type="gene ID" value="SDY_1110"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1110"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1304"/>
    <dbReference type="HOGENOM" id="CLU_078487_0_1_6"/>
    <dbReference type="OMA" id="CFGYLRG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011978">
        <property type="entry name" value="UPF0149"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036255">
        <property type="entry name" value="YgfB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03695">
        <property type="entry name" value="UPF0149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101327">
        <property type="entry name" value="SSF101327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02292">
        <property type="entry name" value="ygfB_yecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="221" mass="24981" checksum="28EAE59E3851E866" modified="2005-12-06" version="1">MKTGPLNESELEWLDDILTKYNTDHAILDVAELDGLLTAVLSSPQEIEPAQWLVAVWGGADYVPRWASEKEMTRFMNLAFQHMADTAERLNEFPEQFEPLFGLREVDGSELTIVEEWCFGYMRGVALSDWSTLPDSLKPALEAIALHGTEENFERVEKMSPEAFEESVDAIRLAALDLHAYWMAHPQEKAVQQPIKAEEKPGRNDPCPCGSGKKFKQCCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HH1</accession>
    <name>Q32HH1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402725.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HH1"/>
    <dbReference type="EnsemblBacteria" id="ABB61234">
        <property type="protein sequence ID" value="ABB61234"/>
        <property type="gene ID" value="SDY_1069"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1069"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1257"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="LRINEGW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27440" checksum="17E77A034A8741F5" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTPKNESLGHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HJ2</accession>
    <name>Q32HJ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yedI</name>
        <name evidence="2" type="ordered locus">SDY_1048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000922683.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402704.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HJ2"/>
    <dbReference type="STRING" id="300267.SDY_1048"/>
    <dbReference type="EnsemblBacteria" id="ABB61213">
        <property type="protein sequence ID" value="ABB61213"/>
        <property type="gene ID" value="SDY_1048"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1048"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1224"/>
    <dbReference type="HOGENOM" id="CLU_059391_0_0_6"/>
    <dbReference type="OMA" id="LWAITKG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008526">
        <property type="entry name" value="YedI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30503">
        <property type="entry name" value="PTHR30503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05661">
        <property type="entry name" value="DUF808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016660">
        <property type="entry name" value="YedI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="305" mass="32133" checksum="264454A053A8CEB5" modified="2005-12-06" version="1">MLLAGSSLLTLLDDIATLLDDISVMGKLAAKKTAGVLGDDLSLNAQQVSGVRANRELPVVWGVAKGSLINKVILVPLALIISAFIPWAITPLLMIGGAFLCFEGVEKVLHMLEARKHKEDPAQSQQRLEKLAAQDPLKFEKDKIKGAIRTDFILSAEIVAITLGIVAEAPLLNQVLVLSGIALVVTVGVYGLVGVIVKIDDLGYWLAEKSSALMQALGKGLLIIAPWLMKALSIVGTLAMFLVGGGIVVHGIAPLHHAIEHFAGQQSAVVAMILPTVLNLILGFIIGGIVVLGVKAVAKMRGQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HL5</accession>
    <name>Q32HL5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">iroC</name>
        <name evidence="10" type="ordered locus">SDY_1025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378643.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402681.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HL5"/>
    <dbReference type="STRING" id="300267.SDY_1025"/>
    <dbReference type="EnsemblBacteria" id="ABB61190">
        <property type="protein sequence ID" value="ABB61190"/>
        <property type="gene ID" value="SDY_1025"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1025"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1198"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_6_6"/>
    <dbReference type="OMA" id="LFMLPMT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="869"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="29"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="341"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="650"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="963"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1004"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1219" mass="131749" checksum="73D8656D58C20F4D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HN6</accession>
    <name>YCDX_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable phosphatase YcdX</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycdX</name>
        <name type="ordered locus">SDY_1003</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 3 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHP family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000283663.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402660.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HN6"/>
    <dbReference type="SMR" id="Q32HN6"/>
    <dbReference type="STRING" id="300267.SDY_1003"/>
    <dbReference type="EnsemblBacteria" id="ABB61169">
        <property type="protein sequence ID" value="ABB61169"/>
        <property type="gene ID" value="SDY_1003"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1003"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1172"/>
    <dbReference type="HOGENOM" id="CLU_061999_0_1_6"/>
    <dbReference type="OMA" id="SEPNCRA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01561">
        <property type="entry name" value="YcdX_phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023710">
        <property type="entry name" value="Phosphatase_YcdX_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000228702" description="Probable phosphatase YcdX">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01561"/>
        </source>
    </evidence>
    <sequence length="245" mass="26818" checksum="5DA8D4AB462D4F13" modified="2005-12-06" version="1">MYPVDLHMHTVASTHAYSTLSDYIAQAKQKGIKLFAITDHGPDMEDAPHHWHFINMRIWPRVVDGVGILRGIEANIKNVDGEIDCSGKMFDSLDLIIAGFHEPVFAPHDKATNTQAMIATIASGNVHIISHPGNPKYEIDVKAVAEAAAKHQVALEINNSSFLHSRKGSEDNCRAVAAAVRDAGGWVALGSDSHTAFSMGEFEECLKILDAVDFPPERILNVSPRRLLNFLESRGMAPIAEFADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HN9</accession>
    <name>Q32HN9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402657.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HN9"/>
    <dbReference type="EnsemblBacteria" id="ABB61166">
        <property type="protein sequence ID" value="ABB61166"/>
        <property type="gene ID" value="SDY_1000"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1000"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1169"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15338" checksum="0CE065E19756451A" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HS8</accession>
    <name>Q32HS8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yccB</name>
        <name evidence="2" type="ordered locus">SDY_0955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378627.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402618.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HS8"/>
    <dbReference type="EnsemblBacteria" id="ABB61127">
        <property type="protein sequence ID" value="ABB61127"/>
        <property type="gene ID" value="SDY_0955"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0955"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1103"/>
    <dbReference type="HOGENOM" id="CLU_218326_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012994">
        <property type="entry name" value="YbgT_YccB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08173">
        <property type="entry name" value="YbgT_YccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="30" mass="3612" checksum="3127FCD53332806A" modified="2005-12-06" version="1">MWYLLWFIGILLMCSLSTLVLVWLDPRLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HT4</accession>
    <name>Q32HT4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydrogenase-1 large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hyaB</name>
        <name evidence="7" type="ordered locus">SDY_0948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HT4"/>
    <dbReference type="STRING" id="300267.SDY_0948"/>
    <dbReference type="EnsemblBacteria" id="ABB61121">
        <property type="protein sequence ID" value="ABB61121"/>
        <property type="gene ID" value="SDY_0948"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0948"/>
    <dbReference type="HOGENOM" id="CLU_030087_0_0_6"/>
    <dbReference type="OMA" id="LMAGRIC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="568" mass="63166" checksum="703A5E06CA32A3DD" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HT8</accession>
    <name>Q32HT8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 6">Acylphosphatase</fullName>
            <ecNumber evidence="3 5 6">3.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acylphosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yccX</name>
        <name evidence="10" type="ordered locus">SDY_0943</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6 7">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 8">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 5 6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000048252.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402608.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HT8"/>
    <dbReference type="SMR" id="Q32HT8"/>
    <dbReference type="STRING" id="300267.SDY_0943"/>
    <dbReference type="EnsemblBacteria" id="ABB61117">
        <property type="protein sequence ID" value="ABB61117"/>
        <property type="gene ID" value="SDY_0943"/>
    </dbReference>
    <dbReference type="GeneID" id="60899857"/>
    <dbReference type="KEGG" id="sdy:SDY_0943"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1091"/>
    <dbReference type="HOGENOM" id="CLU_141932_1_2_6"/>
    <dbReference type="OMA" id="VGFRWSM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01450">
        <property type="entry name" value="Acylphosphatase_entero"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028627">
        <property type="entry name" value="Acylphosphatase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="92" mass="10300" checksum="C39D3D145598D873" modified="2005-12-06" version="1">MSKVCIIAWVYGRVQGVGFRYTTQYEAKRLGLTGYAKNLDDGSVEVVACGEEGQVEKLMQWLKSGGPRSARVERVLSEPHHPSGELTDFRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HZ1</accession>
    <name>Q32HZ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_0887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HZ1"/>
    <dbReference type="EnsemblBacteria" id="ABB61064">
        <property type="protein sequence ID" value="ABB61064"/>
        <property type="gene ID" value="SDY_0887"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0887"/>
    <dbReference type="HOGENOM" id="CLU_076276_5_2_6"/>
    <dbReference type="OMA" id="CRCMNPA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7833" checksum="30C819D8A224F2F8" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGCRCMNPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I80</accession>
    <name>YBIX_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKHD-type hydroxylase YbiX</fullName>
            <ecNumber evidence="1">1.14.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybiX</name>
        <name type="ordered locus">SDY_0795</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60977" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60977.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000990186.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402466.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I80"/>
    <dbReference type="SMR" id="Q32I80"/>
    <dbReference type="STRING" id="300267.SDY_0795"/>
    <dbReference type="EnsemblBacteria" id="ABB60977">
        <property type="protein sequence ID" value="ABB60977"/>
        <property type="gene ID" value="SDY_0795"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0795"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.918"/>
    <dbReference type="HOGENOM" id="CLU_106663_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00657">
        <property type="entry name" value="Hydroxyl_YbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041097">
        <property type="entry name" value="PKHD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023550">
        <property type="entry name" value="PKHD_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41536">
        <property type="entry name" value="PTHR41536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18331">
        <property type="entry name" value="PKHD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0223">Dioxygenase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0847">Vitamin C</keyword>
    <feature type="chain" id="PRO_0000346521" description="PKHD-type hydroxylase YbiX">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="225" mass="25472" checksum="B12A300F163EBAAA" modified="2008-09-02" version="2">MMYHIPGVLSPQDVARFREQLGQAEWVDGRVTTGAQGAQVKNNQQVDTRSTLYAALQNEVLNAVNQHALFFAAALPRTLSTPLFNRYQNNETYGFHVDGAVRSHPQNGWMRTDLSATLFLSDPESYDGGELVVNDTFGQHRVKLPAGDLVLYPSSSLHCVTPVTRGVRVASFMWIQSMIRDDKKRAMLFELDKNIQSLKSRYGESEEILSLLNLYHNLLREWSEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IB6</accession>
    <name>GSIB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione-binding protein GsiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gsiB</name>
        <name type="ordered locus">SDY_0757</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000090187.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402430.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IB6"/>
    <dbReference type="SMR" id="Q32IB6"/>
    <dbReference type="STRING" id="300267.SDY_0757"/>
    <dbReference type="EnsemblBacteria" id="ABB60941">
        <property type="protein sequence ID" value="ABB60941"/>
        <property type="gene ID" value="SDY_0757"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0757"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.871"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_3_6"/>
    <dbReference type="OMA" id="KESPWVP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000279983" description="Glutathione-binding protein GsiB">
        <location>
            <begin position="27"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P75797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="512" mass="56373" checksum="8030259B88C585DB" modified="2005-12-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IE8</accession>
    <name>Q32IE8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001108110.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402398.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IE8"/>
    <dbReference type="STRING" id="300267.SDY_0725"/>
    <dbReference type="EnsemblBacteria" id="ABB60909">
        <property type="protein sequence ID" value="ABB60909"/>
        <property type="gene ID" value="SDY_0725"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0725"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.840"/>
    <dbReference type="HOGENOM" id="CLU_086683_0_0_6"/>
    <dbReference type="OMA" id="NIGRWIA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="254" mass="28059" checksum="C673B8D9F29BD999" modified="2005-12-06" version="1">MAKPDWEAIESAYRAGVLSLRDIGEKYGVTEGAIRKRAKKLGWARSGGTQVCKNGTQKRKVRTSRKPAITGLTQKSTQLKTESTPDTKPIRGMRTDPPTNPFQPGNQQALKHGGYACRLLLKDEVIEDAKALTLEDELFRLRANNLVAAENIGRWLVSLEDANGDQERKMLIENISAAEKAMMRNTVRIESIVGTLATVGKIFADTAYRKAATDKVSLEADRLRRDAGIDDGNGERDLNDFYSDIQTDAESGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IM9</accession>
    <name>Q32IM9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IM9"/>
    <dbReference type="EnsemblBacteria" id="ABB60828">
        <property type="protein sequence ID" value="ABB60828"/>
        <property type="gene ID" value="SDY_0638"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0638"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="78" mass="8953" checksum="FA82F945CE075A88" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITKLRYSSLPEAVFYCLYMFKYSLHN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-11-16" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IN7</accession>
    <name>SEQA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Negative modulator of initiation of replication</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">seqA</name>
        <name type="ordered locus">SDY_0627</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Polymerizes to form helical filaments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SeqA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019869.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402309.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IN7"/>
    <dbReference type="SMR" id="Q32IN7"/>
    <dbReference type="STRING" id="300267.SDY_0627"/>
    <dbReference type="EnsemblBacteria" id="ABB60820">
        <property type="protein sequence ID" value="ABB60820"/>
        <property type="gene ID" value="SDY_0627"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0627"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.728"/>
    <dbReference type="HOGENOM" id="CLU_099733_0_0_6"/>
    <dbReference type="OMA" id="RTRTYFA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032297">
        <property type="term" value="P:negative regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00908">
        <property type="entry name" value="SeqA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005621">
        <property type="entry name" value="SeqA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026577">
        <property type="entry name" value="SeqA_DNA-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036835">
        <property type="entry name" value="SeqA_DNA-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033761">
        <property type="entry name" value="SeqA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03925">
        <property type="entry name" value="SeqA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17206">
        <property type="entry name" value="SeqA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019401">
        <property type="entry name" value="SeqA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82808">
        <property type="entry name" value="SSF82808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0236">DNA replication inhibitor</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413941" description="Negative modulator of initiation of replication">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="1">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="1">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="1">
        <location>
            <begin position="150"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00908"/>
        </source>
    </evidence>
    <sequence length="181" mass="20290" checksum="21F0F8B3A3D7229B" modified="2005-12-06" version="1">MKTIEVDDELYSYIASHTKHIGESASDILRRMLKFSAASQPAAPVTKEVRVASPAIVEAKPVKTIKDKVRAMRELLLSDEYAEQKRAVNRFMLLLSTLYSLDAQAFAEATESLHGRTRVYFAADEQTLLKNGNQTKPKHVSGTPYWVITNTNTGRKCSMIEHIMLSMQFPAELIEKVCGTI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IU9</accession>
    <name>YBED_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0250 protein YbeD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybeD</name>
        <name type="ordered locus">SDY_0553</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0250 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000850550.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402247.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IU9"/>
    <dbReference type="SMR" id="Q32IU9"/>
    <dbReference type="STRING" id="300267.SDY_0553"/>
    <dbReference type="EnsemblBacteria" id="ABB60758">
        <property type="protein sequence ID" value="ABB60758"/>
        <property type="gene ID" value="SDY_0553"/>
    </dbReference>
    <dbReference type="GeneID" id="67416327"/>
    <dbReference type="KEGG" id="sdy:SDY_0553"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.654"/>
    <dbReference type="HOGENOM" id="CLU_161438_2_1_6"/>
    <dbReference type="OMA" id="MNTKFDE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00659">
        <property type="entry name" value="UPF0250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007454">
        <property type="entry name" value="UPF0250"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027471">
        <property type="entry name" value="YbeD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38036">
        <property type="entry name" value="PTHR38036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04359">
        <property type="entry name" value="DUF493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117991">
        <property type="entry name" value="SSF117991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000061900" description="UPF0250 protein YbeD">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00659"/>
        </source>
    </evidence>
    <sequence length="87" mass="9827" checksum="13B14D3B2A6E1F95" modified="2005-12-06" version="1">MKTKLNELLEFPTPFTYKVMGQALPELVDQVVEVVQRHAPGDYTPTVKPSSKGNYHSVSITINATHIEQVETLYEELGKIDIVRMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IV6</accession>
    <name>Q32IV6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspE</name>
        <name evidence="4" type="ordered locus">SDY_0546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000034825.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402240.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IV6"/>
    <dbReference type="SMR" id="Q32IV6"/>
    <dbReference type="STRING" id="300267.SDY_0546"/>
    <dbReference type="EnsemblBacteria" id="ABB60751">
        <property type="protein sequence ID" value="ABB60751"/>
        <property type="gene ID" value="SDY_0546"/>
    </dbReference>
    <dbReference type="GeneID" id="64171175"/>
    <dbReference type="GeneID" id="67516440"/>
    <dbReference type="KEGG" id="sdy:SDY_0546"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.646"/>
    <dbReference type="HOGENOM" id="CLU_117621_2_1_6"/>
    <dbReference type="OMA" id="IWQKERG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="7463" checksum="1C33C920AA82405C" modified="2005-12-06" version="1">MSKIKGNVKWFNESKGFGFITPEDGSKDVFVHFSAIQTNGFKTLAEGQRVEFEITNGAKGPSAANVIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J75</accession>
    <name>Q32J75_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J75"/>
    <dbReference type="STRING" id="300267.SDY_0421"/>
    <dbReference type="EnsemblBacteria" id="ABB60632">
        <property type="protein sequence ID" value="ABB60632"/>
        <property type="gene ID" value="SDY_0421"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0421"/>
    <dbReference type="HOGENOM" id="CLU_1199124_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="221" mass="23288" checksum="02320D6F90954614" modified="2005-12-06" version="1">MQSTDPLTWSKTALTLYQSGNNYATSSIADYDRNGTGDLFITRDDYGTGYINGFTNNGDGTFSSAIQVTVGTLTWYGSIVAFDKEGDGYLDFWIGDAGGPDSNTFLWNNAGTLVGNSTTSNSGGSATVGGAVTGYLSLNEGSGVDLNNDGRIDLVQHTYNLNNYYTLSSLINQGNGTLVWGQNTTNTFLSGADSGAMSSSVSMTWADFDGDGDMDLFLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JC9</accession>
    <name>Q32JC9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402067.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JC9"/>
    <dbReference type="STRING" id="300267.SDY_0364"/>
    <dbReference type="EnsemblBacteria" id="ABB60578">
        <property type="protein sequence ID" value="ABB60578"/>
        <property type="gene ID" value="SDY_0364"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0364"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.429"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15346" checksum="120532219751326A" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JH9</accession>
    <name>Q32JH9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Geranyltranstransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispA</name>
        <name evidence="4" type="ordered locus">SDY_0309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000347217.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402017.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JH9"/>
    <dbReference type="SMR" id="Q32JH9"/>
    <dbReference type="STRING" id="300267.SDY_0309"/>
    <dbReference type="EnsemblBacteria" id="ABB60528">
        <property type="protein sequence ID" value="ABB60528"/>
        <property type="gene ID" value="SDY_0309"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0309"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.355"/>
    <dbReference type="HOGENOM" id="CLU_014015_0_1_6"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="299" mass="32160" checksum="15BADD5E135060CA" modified="2005-12-06" version="1">MDFPQQLEACVKQANQALSRFIAPLPFQNTPVVETMQYGALLGGKRLRPFLVYATGHMFGVSTNTLDAPAAAVECIHAYSLIHDDLPAMDDDDLRRGLPTCHVKFGEANAILAGDALQTLAFSILSDADMPEVSDRDRISMISELASASGIAGMCGGQALDLDAEGKHVPLDALERIHRHKTGALIRAAVRLGALSAGDKGRRALPVLDKYAESIGLAFQVQDDILDVVGDTATLGKRQGADQQLGKSTYPALLGLEQARKKARDLIDDARQSLKQLAEQSLDTSALEALADYIIQRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JJ9</accession>
    <name>Q32JJ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JJ9"/>
    <dbReference type="EnsemblBacteria" id="ABB60508">
        <property type="protein sequence ID" value="ABB60508"/>
        <property type="gene ID" value="SDY_0289"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0289"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9688" checksum="C82078B8C33C0E14" modified="2005-12-06" version="1">MTVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITRCFYKNCYKYRGHNWYDLFSLAKNCHYAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JV4</accession>
    <name>GSA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="1">GSA</shortName>
            <ecNumber evidence="1">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="1">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemL</name>
        <name type="ordered locus">SDY_0170</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000045322.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401892.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JV4"/>
    <dbReference type="SMR" id="Q32JV4"/>
    <dbReference type="STRING" id="300267.SDY_0170"/>
    <dbReference type="EnsemblBacteria" id="ABB60403">
        <property type="protein sequence ID" value="ABB60403"/>
        <property type="gene ID" value="SDY_0170"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0170"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.196"/>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_6"/>
    <dbReference type="OMA" id="WGPLIFG"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000243616" description="Glutamate-1-semialdehyde 2,1-aminomutase">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <sequence length="426" mass="45392" checksum="B5B8EDE7071DA3AF" modified="2005-12-06" version="1">MSKSENLYSAARELIPSGVNSPVRAFTGVGGTPLFIEKADGAYLYDVDGKAYIDYVGSWGPMVLGHNHPAIRNAVIEAAERGLSFGAPTEMEVKMAQLVTELVPTMDMVRMVNSGTEATMSAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPADFAKHTLTCTYNDLASVRAAFEQYPQEIACIIVEPVAGNMNCVPPLPEFLPGLRALCDEFGALLIIDEVMTGFRVALAGAQDYYGVVPDLTCLGKIIGGGMPVGAFGGRRDVMDALAPTGPVYQAGTLSGNPIAMAAGFACLNEVAQPGVHETLHELTTRLAEGLLEAAEEAGIPLVVNHVGGMFGIFFTDAESVTCYQDVMACDVERFKRFFHMMLDEGVYLAPSAFEAGFMSVAHSMEDINNTIDAARRVFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JX8</accession>
    <name>Q32JX8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="7">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aceF</name>
        <name evidence="10" type="ordered locus">SDY_0145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="7">Binds 3 lipoyl cofactors covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Forms a 24-polypeptide structural core with octahedral symmetry.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000963530.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401868.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JX8"/>
    <dbReference type="STRING" id="300267.SDY_0145"/>
    <dbReference type="EnsemblBacteria" id="ABB60379">
        <property type="protein sequence ID" value="ABB60379"/>
        <property type="gene ID" value="SDY_0145"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0145"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.163"/>
    <dbReference type="HOGENOM" id="CLU_016733_10_0_6"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006256">
        <property type="entry name" value="AcTrfase_Pyrv_DH_cplx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF2">
        <property type="entry name" value="PTHR43178:SF2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01348">
        <property type="entry name" value="PDHac_trf_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="206"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="324"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="626" mass="65783" checksum="4EADFA36B5EAD8AB" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K05</accession>
    <name>MRAY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="1">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraY</name>
        <name type="ordered locus">SDY_0117</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000964134.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401841.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K05"/>
    <dbReference type="SMR" id="Q32K05"/>
    <dbReference type="STRING" id="300267.SDY_0117"/>
    <dbReference type="EnsemblBacteria" id="ABB60352">
        <property type="protein sequence ID" value="ABB60352"/>
        <property type="gene ID" value="SDY_0117"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0117"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.136"/>
    <dbReference type="HOGENOM" id="CLU_023982_0_0_6"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000235481" description="Phospho-N-acetylmuramoyl-pentapeptide-transferase">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="257"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="359"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <sequence length="360" mass="39903" checksum="922AB374BC9E8F2E" modified="2005-12-06" version="1">MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLVGKDTPATQLVVPFFKDVMPQLGLFYILLAYFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K54</accession>
    <name>Q32K54_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FixC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fixC</name>
        <name evidence="5" type="ordered locus">SDY_0065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of an electron transfer system.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K54"/>
    <dbReference type="STRING" id="300267.SDY_0065"/>
    <dbReference type="EnsemblBacteria" id="ABB60303">
        <property type="protein sequence ID" value="ABB60303"/>
        <property type="gene ID" value="SDY_0065"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0065"/>
    <dbReference type="HOGENOM" id="CLU_050977_0_0_6"/>
    <dbReference type="OMA" id="GEWAVRI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="PTHR43624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="4">
        <location>
            <begin position="30"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="349" mass="37727" checksum="214FE8BB42BD5AB3" modified="2005-12-06" version="1">MTEKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQVEEAGAQLITEIRVDNLVQRDGKVVGVEADGDVIEAKTVILADGVNSILAEKLGMAKRVKPTDVAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCGLHHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEEGINMLPELVGDGVLIAGDAAGMCMNLGFTIRGMDLAIAAGEAAAKTVLSAMKSDDFSKQKLAEYRQHLESGPLRDMRMYQKLPAFLDNPRMFSGYPELAVGVARDLFTIDGSAQELMRKKILRHGKKVGFINLIKDGMKGVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K73</accession>
    <name>Q32K73_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001300728.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401773.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K73"/>
    <dbReference type="STRING" id="300267.SDY_0046"/>
    <dbReference type="EnsemblBacteria" id="ABB60284">
        <property type="protein sequence ID" value="ABB60284"/>
        <property type="gene ID" value="SDY_0046"/>
    </dbReference>
    <dbReference type="GeneID" id="58390373"/>
    <dbReference type="KEGG" id="sdy:SDY_0046"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.50"/>
    <dbReference type="HOGENOM" id="CLU_2716372_0_0_6"/>
    <dbReference type="OMA" id="CICLIAM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="7890" checksum="57B487A8B57BFF78" modified="2005-12-06" version="1">MCRHSLRSDGAGFYQLAGCEYSFSAIKIAAGGQFLPVICAMAMKSHFFLISVLNRRLTLTAVQGILGRFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KA7</accession>
    <name>Q32KA7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_0011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0174 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001102350.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401739.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KA7"/>
    <dbReference type="STRING" id="300267.SDY_0011"/>
    <dbReference type="EnsemblBacteria" id="ABB60251">
        <property type="protein sequence ID" value="ABB60251"/>
        <property type="gene ID" value="SDY_0011"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0011"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.11"/>
    <dbReference type="HOGENOM" id="CLU_072312_0_1_6"/>
    <dbReference type="OMA" id="HIACLRQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025217">
        <property type="entry name" value="DUF3944"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13099">
        <property type="entry name" value="DUF3944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3944" evidence="3">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiq_cyt_C_chap" evidence="2">
        <location>
            <begin position="58"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="26609" checksum="DDE2958A15C77C33" modified="2005-12-06" version="1">MNVNYLNDSDLDFLQHCSEEQLANFAQLLTHNEKGKTRLSSVLMRNELFKSMEGHPEQHRRNWQLIAGELQHFGGDSIANKLRGHGKLYRAILLDVSKRLKLKADKEMSTFEIEQQLLEQFLRNTWKKMDEEHKQEFLHAVDAKVNELEELLPLLMKDKLLAKGVSHLLSSQLTRILRTHAAMSVLGHGLLRGAGLGGPVGAALNGVKAVSGSAYRVTIPAVLQIACLRRMVSATQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q326M1</accession>
    <name>Q326M1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">IcsP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">icsP</name>
        <name evidence="14" type="ordered locus">SDY_P224</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="14 15">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Sd197</strain>
            <plasmid evidence="15">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406225.2">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326M1"/>
    <dbReference type="MEROPS" id="A26.005"/>
    <dbReference type="EnsemblBacteria" id="ABB64737">
        <property type="protein sequence ID" value="ABB64737"/>
        <property type="gene ID" value="SDY_P224"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P224"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5777"/>
    <dbReference type="HOGENOM" id="CLU_063041_1_0_6"/>
    <dbReference type="OMA" id="HENFEFG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020080">
        <property type="entry name" value="OM_adhesin/peptidase_omptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020079">
        <property type="entry name" value="Peptidase_A26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000036">
        <property type="entry name" value="Peptidase_A26_omptin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01278">
        <property type="entry name" value="Omptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001522">
        <property type="entry name" value="Peptidase_A26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00482">
        <property type="entry name" value="OMPTIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69917">
        <property type="entry name" value="SSF69917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00834">
        <property type="entry name" value="OMPTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00835">
        <property type="entry name" value="OMPTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220900" evidence="13">
        <location>
            <begin position="32"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001522-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB64737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="326" mass="36967" checksum="67D214F07F47852F" modified="2005-12-06" version="1">MDISTKKVEFSMKLKFLVLALCVPAIFTTHATTNYPLFIPDNISTDISLGSLSGKTKERVYHPKEGGRKISQLDWKYSNATIVRGGIDWKLIPKVSFGVSGWTTLGNQKASMVDKDWNNSNTPQIWTDQSWHPNTHLRDANEFELNLKGWLLNNLDYRLGLIAGYQESRYSFNAMGGSYIYSENGGNRNKKGAHPSGERTIGYKQLFKIPYIGLTANYRHENFEFGAELKYSGWVRSSDTDKHYQTETIFKDEIKNQNYRSVAANIGYYVTPSAKFYIEGSRNYISNKKGDTSLYEQSTNISGTIKNSASIEYIGFLTSAGIKYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q326P4</accession>
    <name>Q326P4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406202.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326P4"/>
    <dbReference type="EnsemblBacteria" id="ABB64714">
        <property type="protein sequence ID" value="ABB64714"/>
        <property type="gene ID" value="SDY_P201"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P201"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5752"/>
    <dbReference type="HOGENOM" id="CLU_141050_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14769" checksum="F58EDBD0ED3D2726" modified="2005-12-06" version="1">MTESRQEKLIWLRAQMKLTSLCWALKELAKDIWSRPWSEERRNDWQRWLSLAANSDVPMMKNVAKTIGKRLYGILNTMRHGVSNGNAEALNSKIRLLRIKAKGYRNRERFKLGVMFHYGKLNMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q326V5</accession>
    <name>Q326V5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4021</name>
        <name evidence="2" type="ordered locus">SDY_P141</name>
        <name evidence="3" type="ordered locus">SDY_P148</name>
        <name evidence="4" type="ordered locus">SDY_PA07</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pSD197_spA</name>
    </geneLocation>
    <geneLocation type="plasmid" evidence="2 5">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">Sd197</strain>
            <plasmid evidence="5">Plasmid pSD197_spA</plasmid>
            <plasmid evidence="5">Plasmid pSD1_197</plasmid>
            <plasmid evidence="4">pSD197_spA</plasmid>
            <plasmid evidence="2">pSD1_197</plasmid>
            <plasmid evidence="2">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2007-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Yang F."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">pSD197_spA</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000640">
        <property type="protein sequence ID" value="ABO87501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000019161.1">
        <property type="nucleotide sequence ID" value="NC_009344.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001139950.1">
        <property type="nucleotide sequence ID" value="NC_009344.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405430.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406141.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406149.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63939">
        <property type="protein sequence ID" value="ABB63939"/>
        <property type="gene ID" value="SDY_4021"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64654">
        <property type="protein sequence ID" value="ABB64654"/>
        <property type="gene ID" value="SDY_P141"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64661">
        <property type="protein sequence ID" value="ABB64661"/>
        <property type="gene ID" value="SDY_P148"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABO87501">
        <property type="protein sequence ID" value="ABO87501"/>
        <property type="gene ID" value="SDY_PA07"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4021"/>
    <dbReference type="KEGG" id="sdy:SDY_P141"/>
    <dbReference type="KEGG" id="sdy:SDY_P148"/>
    <dbReference type="KEGG" id="sdy:SDY_PA07"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4734"/>
    <dbReference type="HOGENOM" id="CLU_2436307_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD197_spA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABO87501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="10740" checksum="2B4ECEBECD6EB504" modified="2005-12-06" version="1">MSHNLEHQKVHTRMVKEVLKAVARANNHPYQSVFTDFIAGHPSCTVCFWETFHKMSPDSPYEYVTFCHTCRRFDLYETEAEMKADDPKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q327C7</accession>
    <name>Q327C7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISSfl1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406069.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327C7"/>
    <dbReference type="EnsemblBacteria" id="ABB64581">
        <property type="protein sequence ID" value="ABB64581"/>
        <property type="gene ID" value="SDY_P068"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P068"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5616"/>
    <dbReference type="HOGENOM" id="CLU_055261_9_2_6"/>
    <dbReference type="OMA" id="VADIECA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13586">
        <property type="entry name" value="DDE_Tnp_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="129" mass="14941" checksum="98CAF40DFFB5FFD9" modified="2005-12-06" version="1">MLSPGQAHESQFAQRLLDGIGVQRQNGSMKRRGHAVLVDKAYSGRALRNELKNNGIKAVIPRKSNEKMASDGRAQLDRDAYRNRNVVERCFGRLKEYRRIATRYDKTARNYLAMVKLGCIRLFYQRLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q327D1</accession>
    <name>Q327D1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UshA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ushA</name>
        <name evidence="5" type="ordered locus">SDY_P064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Sd197</strain>
            <plasmid evidence="6">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406065.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327D1"/>
    <dbReference type="EnsemblBacteria" id="ABB64577">
        <property type="protein sequence ID" value="ABB64577"/>
        <property type="gene ID" value="SDY_P064"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P064"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5611"/>
    <dbReference type="HOGENOM" id="CLU_005854_7_0_6"/>
    <dbReference type="OMA" id="HYADGQN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="52"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="4">
        <location>
            <begin position="381"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="567" mass="63101" checksum="A1FC4325A9EE844A" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q327T4</accession>
    <name>Q327T4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Cyclic di-GMP-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cellulose synthase regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">yhjN</name>
        <name evidence="12" type="ordered locus">SDY_4552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Glycan metabolism; bacterial cellulose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Tightly associated with the cellulose synthase catalytic subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AcsB/BcsB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021118.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405912.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327T4"/>
    <dbReference type="STRING" id="300267.SDY_4552"/>
    <dbReference type="EnsemblBacteria" id="ABB64421">
        <property type="protein sequence ID" value="ABB64421"/>
        <property type="gene ID" value="SDY_4552"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4552"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5383"/>
    <dbReference type="HOGENOM" id="CLU_003556_1_1_6"/>
    <dbReference type="OMA" id="FQYMNPM"/>
    <dbReference type="UniPathway" id="UPA00694"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003920">
        <property type="entry name" value="Cell_synth_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018513">
        <property type="entry name" value="Cell_synthase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39083">
        <property type="entry name" value="PTHR39083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03170">
        <property type="entry name" value="BcsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01440">
        <property type="entry name" value="CELLSNTHASEB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0973">c-di-GMP</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0135">Cellulose biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015218270" description="Cyclic di-GMP-binding protein" evidence="11">
        <location>
            <begin position="26"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB64421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="779" mass="85924" checksum="27873A999597F10B" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q327U7</accession>
    <name>UBIA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxybenzoate octaprenyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-HB polyprenyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiA</name>
        <name type="ordered locus">SDY_4534</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27782"/>
            <dbReference type="ChEBI" id="CHEBI:1617"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57711"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000455227.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405899.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327U7"/>
    <dbReference type="SMR" id="Q327U7"/>
    <dbReference type="STRING" id="300267.SDY_4534"/>
    <dbReference type="EnsemblBacteria" id="ABB64408">
        <property type="protein sequence ID" value="ABB64408"/>
        <property type="gene ID" value="SDY_4534"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4534"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5358"/>
    <dbReference type="HOGENOM" id="CLU_034879_1_0_6"/>
    <dbReference type="OMA" id="MVVYPYG"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002083">
        <property type="term" value="F:4-hydroxybenzoate decaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047293">
        <property type="term" value="F:4-hydroxybenzoate nonaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="chain" id="PRO_0000262843" description="4-hydroxybenzoate octaprenyltransferase">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01635"/>
        </source>
    </evidence>
    <sequence length="290" mass="32512" checksum="F10FED1D7A30E115" modified="2005-12-06" version="1">MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYYWSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q327X1</accession>
    <name>Q327X1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">uvrA</name>
        <name evidence="16" type="ordered locus">SDY_4509</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000357751.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405875.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327X1"/>
    <dbReference type="STRING" id="300267.SDY_4509"/>
    <dbReference type="EnsemblBacteria" id="ABB64384">
        <property type="protein sequence ID" value="ABB64384"/>
        <property type="gene ID" value="SDY_4509"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4509"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5330"/>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_6"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="607"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="740"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="640"/>
            <end position="647"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB64384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="940" mass="103925" checksum="3C2569B6D21697B4" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Z7</accession>
    <name>Q327Z7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LZ_Tnp_IS66 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405849.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Z7"/>
    <dbReference type="STRING" id="300267.SDY_4482"/>
    <dbReference type="EnsemblBacteria" id="ABB64358">
        <property type="protein sequence ID" value="ABB64358"/>
        <property type="gene ID" value="SDY_4482"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4482"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5292"/>
    <dbReference type="HOGENOM" id="CLU_023034_7_4_6"/>
    <dbReference type="OMA" id="TIHPKLA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024463">
        <property type="entry name" value="Transposase_TnpC_homeodom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13007">
        <property type="entry name" value="LZ_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LZ_Tnp_IS66" evidence="2">
        <location>
            <begin position="40"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="136" mass="15039" checksum="33E1260AC21B4AC3" modified="2005-12-06" version="1">MNNTLPDDIEQLKALLIAQQAVIVRLSGEITGYAREISSLRALVAKLQRMLFGRSSEKSREKIEKKIARAETRITELQNRLGEAQLQLTSMAGETAPKTSDSPVRKALPATLPRDRQVISPAETECPVCSGKLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Z8</accession>
    <name>Q327Z8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ISSfl4 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000631696.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405848.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Z8"/>
    <dbReference type="STRING" id="300267.SDY_4481"/>
    <dbReference type="EnsemblBacteria" id="ABB64357">
        <property type="protein sequence ID" value="ABB64357"/>
        <property type="gene ID" value="SDY_4481"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4481"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5291"/>
    <dbReference type="HOGENOM" id="CLU_128110_1_0_6"/>
    <dbReference type="OMA" id="HDGQGSC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008878">
        <property type="entry name" value="Transposase_IS66_Orf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36455">
        <property type="entry name" value="PTHR36455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05717">
        <property type="entry name" value="TnpB_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="111" mass="12601" checksum="86EE9A142EA18B9B" modified="2005-12-06" version="1">MITLPTGTKIWIIAGITDMRCGFNGLASKVQNTLKDDPFSGHIFVFRGRSAKLWADRDGLCLFAKRLERGRFVWPVTREGKVHLTPAQLSMLLEGIAWQHPKRTERPGIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q328B2</accession>
    <name>Q328B2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ppa</name>
        <name evidence="6" type="ordered locus">SDY_4462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000055075.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405834.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328B2"/>
    <dbReference type="SMR" id="Q328B2"/>
    <dbReference type="STRING" id="300267.SDY_4462"/>
    <dbReference type="EnsemblBacteria" id="ABB64343">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
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            <position position="30"/>
        </location>
        <ligand>
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        </location>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="176" mass="19704" checksum="4C97E51F3BE650DE" modified="2005-12-06" version="1">MSLLNVPAGKDLPEDIYVVIEIPANADPIKYEIDKESGALFVDRFMSTAMFYPCNYGYINHTLSLDGDPVDVLVPTPYPLQPGSVIRCRPVGVLKMTDEAGEDAKLVAVPHSKLSKEYDHIKDVNDLPELLKAQIAHFFEHYKDLEKGKWVKVEGWENAEAAKAEIVASFERAKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q328B7</accession>
    <name>Q328B7_SHIDS</name>
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        <alternativeName>
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    </protein>
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    </gene>
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        <lineage>
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            <taxon>Enterobacteriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="577" mass="64750" checksum="D539236F392B9648" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q328B9</accession>
    <name>Q328B9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ytfL</name>
        <name evidence="12" type="ordered locus">SDY_4455</name>
    </gene>
    <organism evidence="12 13">
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Gammaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405827.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328B9"/>
    <dbReference type="STRING" id="300267.SDY_4455"/>
    <dbReference type="EnsemblBacteria" id="ABB64336">
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        <property type="gene ID" value="SDY_4455"/>
    </dbReference>
    <dbReference type="GeneID" id="58463646"/>
    <dbReference type="KEGG" id="sdy:SDY_4455"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5255"/>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_6"/>
    <dbReference type="OMA" id="YLTMEDV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
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    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="282"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB64336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="447" mass="49781" checksum="25C7AAFC4723066E" modified="2005-12-06" version="1">MLNSILVILCLIAVSAFFSMSEISLAASRKIKLKLLADEGNINAQRVLNMQENPGMFFTVVQIGLNAVAILGGIVGDAAFSPAFHSLFSRYMSAELSEQLSFILSFSLVTGMFILFADLTPKRIGMIAPEAVALRIINPMRFCLYVCTPLVWFFNGLANMIFRIFKLPMVRKDDITSDDIYAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTPRENVIWFDLHEDEQSLKNKVAEHPHSKFLVCNEDIDHIIGYVDSKDLLNRVLANQSLALNSGVQIRNTLIVPDTLTLSEALESFKTAGEDFAVIMNEYALVVGIITLNDVMTTLMGDLVGQGLEEQIVARDENSWLIDGGTPIDDVMRVLDIDEFPQSGNYETIGGFMMFMLRKIPKRTDSVKFAGYKFEVVDIDNYRIDQLLVTRIDSKATALSPKLPDAKDKEESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q328D0</accession>
    <name>Q328D0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anaerobic C4-dicarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dcuA</name>
        <name evidence="10" type="ordered locus">SDY_4443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 8">Cell inner membrane</location>
            <topology evidence="3 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000961953.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405816.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328D0"/>
    <dbReference type="STRING" id="300267.SDY_4443"/>
    <dbReference type="EnsemblBacteria" id="ABB64325">
        <property type="protein sequence ID" value="ABB64325"/>
        <property type="gene ID" value="SDY_4443"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4443"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5241"/>
    <dbReference type="HOGENOM" id="CLU_036056_1_1_6"/>
    <dbReference type="OMA" id="PKQINYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015556">
        <property type="term" value="F:C4-dicarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004668">
        <property type="entry name" value="Anaer_Dcu_memb_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36106">
        <property type="entry name" value="PTHR36106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03605">
        <property type="entry name" value="DcuA_DcuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004539">
        <property type="entry name" value="C4-dicrbxl_trns"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00770">
        <property type="entry name" value="Dcu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR004539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="433" mass="45708" checksum="2109B44BF9BD05BE" modified="2005-12-06" version="1">MLVVELIIVLLAIFLGARLGGIGIGFAGGLGVLVLAAIGVKPGNIPFDVISIIMAVIAAISAMQVAGGLDYLVHQTEKLLRRNPKYITILAPIVTYFLTIFAGTGNISLATLPVIAEVAKEQGVKPCRPLSTAVVSAQIAITASPISAAVVYMSSVMEGHGISYLHLLSVVIPSTLLAVLVMSFLVTMLFNSKLSDDPIYRKRLEEGLVELLGEKQIEIKSGAKTSVWLFLLGVVGVVIYAIINSPSMGLVEKPLMNTTNAILIIMLSVATLTTVICKVDTDNILNSSTFKAGMSACICILGVAWLGDTFVSNNIDWIKDTAGEVIQGHPWLLAVIFFFASALLYSQAATAKALMPMALALNVSPLTAVASFAAVSGLFILPTYPTLVAAVQMDDTGTTRIGKFVFNHPFFIPGTLGVALAVCFGFVLGSFML</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q328D2</accession>
    <name>DSBD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiol:disulfide interchange protein DsbD</fullName>
            <ecNumber evidence="1">1.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein-disulfide reductase</fullName>
            <shortName evidence="1">Disulfide reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dsbD</name>
        <name type="ordered locus">SDY_4441</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family. DsbD subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000068970.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405814.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="PDB" id="7AYE">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.95 A"/>
        <property type="chains" value="B=438-565"/>
    </dbReference>
    <dbReference type="PDBsum" id="7AYE"/>
    <dbReference type="AlphaFoldDB" id="Q328D2"/>
    <dbReference type="SMR" id="Q328D2"/>
    <dbReference type="STRING" id="300267.SDY_4441"/>
    <dbReference type="EnsemblBacteria" id="ABB64323">
        <property type="protein sequence ID" value="ABB64323"/>
        <property type="gene ID" value="SDY_4441"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4441"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5239"/>
    <dbReference type="HOGENOM" id="CLU_014657_3_0_6"/>
    <dbReference type="OMA" id="YYADWCV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase (NAD(P)) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02953">
        <property type="entry name" value="DsbDgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00399">
        <property type="entry name" value="DbsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035671">
        <property type="entry name" value="DsbD_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028250">
        <property type="entry name" value="DsbDN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036929">
        <property type="entry name" value="DsbDN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022910">
        <property type="entry name" value="Thiol_diS_interchange_DbsD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32234:SF0">
        <property type="entry name" value="PTHR32234:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11412">
        <property type="entry name" value="DsbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74863">
        <property type="entry name" value="SSF74863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000304397" description="Thiol:disulfide interchange protein DsbD">
        <location>
            <begin position="20"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="434"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="182"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="480"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="451"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="471"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="494"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="500"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="503"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="528"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="532"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="553"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00399"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="2">
        <source>
            <dbReference type="PDB" id="7AYE"/>
        </source>
    </evidence>
    <sequence length="565" mass="61696" checksum="FAB791B98B0B7540" modified="2005-12-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q328E2</accession>
    <name>Q328E2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oligoribonuclease</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yjeR</name>
        <name evidence="3" type="synonym">orn</name>
        <name evidence="5" type="ordered locus">SDY_4430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">3'-to-5' exoribonuclease specific for small oligoribonucleotides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328E2"/>
    <dbReference type="STRING" id="300267.SDY_4430"/>
    <dbReference type="EnsemblBacteria" id="ABB64313">
        <property type="protein sequence ID" value="ABB64313"/>
        <property type="gene ID" value="SDY_4430"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4430"/>
    <dbReference type="HOGENOM" id="CLU_064761_2_0_6"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00045">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="30"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="204" mass="23464" checksum="871388DDCC7529F2" modified="2005-12-06" version="1">MGKTSMIHAIVDQYSHCEWVENSMSANENNLIWIDLEMTGLDPERDRIIEIATLVTDANLNILAEGPTIAVHQSDEQLALMDDWNVRTHTASGLVERVKASTMGDREAELATLEFLKQWVPAGKSPICGNSIGQDRRFLFKYMPELEAYFHYRYLDVSTLKELARRWKPEILDGFTKQGTHQAMDDIRESVAELAYYREHFIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q328M7</accession>
    <name>Q328M7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405719.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328M7"/>
    <dbReference type="STRING" id="300267.SDY_4337"/>
    <dbReference type="EnsemblBacteria" id="ABB64228">
        <property type="protein sequence ID" value="ABB64228"/>
        <property type="gene ID" value="SDY_4337"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4337"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5121"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="115" mass="13472" checksum="C00A3AEF01E919BA" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTIWVMLPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q329E7</accession>
    <name>Q329E7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sensor histidine protein kinase phosphorylates UhpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">uhpB</name>
        <name evidence="10" type="ordered locus">SDY_4149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405549.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329E7"/>
    <dbReference type="STRING" id="300267.SDY_4149"/>
    <dbReference type="EnsemblBacteria" id="ABB64058">
        <property type="protein sequence ID" value="ABB64058"/>
        <property type="gene ID" value="SDY_4149"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4149"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4876"/>
    <dbReference type="HOGENOM" id="CLU_041023_0_0_6"/>
    <dbReference type="OMA" id="FCLWVIA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007895">
        <property type="entry name" value="MASE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05231">
        <property type="entry name" value="MASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="312"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="501" mass="56538" checksum="2FD75608E88EB283" modified="2005-12-06" version="1">MMKTLFSRLITVIACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLIYWLTQAVGLTHFVLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGATLTAAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWHYLANNTWLPLGPSLVSQPINWRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAIALIASQTWRDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNQHLAERLLETEESVRRDVARELHDDIGQTITAIRTQAGIVQRLAADNASVKQSGQLIEQLSLGVYDAVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVRHLEWRIDESALSENQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPGSGQQGFGLTGMRERVTALGGTLHISCLHGTRVSVSLPQRYV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q329N6</accession>
    <name>HLDD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ADP-L-glycero-D-manno-heptose-6-epimerase</fullName>
            <ecNumber evidence="1">5.1.3.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ADP-L-glycero-beta-D-manno-heptose-6-epimerase</fullName>
            <shortName evidence="1">ADP-glyceromanno-heptose 6-epimerase</shortName>
            <shortName evidence="1">ADP-hep 6-epimerase</shortName>
            <shortName evidence="1">AGME</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hldD</name>
        <name type="ordered locus">SDY_4051</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose</text>
            <dbReference type="Rhea" id="RHEA:17577"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61506"/>
            <dbReference type="EC" id="5.1.3.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
        <text evidence="1">Binds 1 NADP(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homopentamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000587758.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405460.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329N6"/>
    <dbReference type="SMR" id="Q329N6"/>
    <dbReference type="STRING" id="300267.SDY_4051"/>
    <dbReference type="EnsemblBacteria" id="ABB63969">
        <property type="protein sequence ID" value="ABB63969"/>
        <property type="gene ID" value="SDY_4051"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4051"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4767"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_3_6"/>
    <dbReference type="OMA" id="LRDFVYI"/>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008712">
        <property type="term" value="F:ADP-glyceromanno-heptose 6-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05248">
        <property type="entry name" value="ADP_GME_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01601">
        <property type="entry name" value="Heptose_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011912">
        <property type="entry name" value="Heptose_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02197">
        <property type="entry name" value="heptose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000255743" description="ADP-L-glycero-D-manno-heptose-6-epimerase">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="31"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="201"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01601"/>
        </source>
    </evidence>
    <sequence length="310" mass="34879" checksum="0B9338A879CB023E" modified="2005-12-06" version="1">MIIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNLVDLNIADYMDKEDFLIQIMAGEDFGDVEAIFHEGACSSTTEWDGKYMMDNNYQYSKELLHYCLEREIPFLYASSAATYGGRTSDFIESREYEKPLNVYGYSKFLFDEYVRQILPEANSQIVGFRYFNVYGPREGHKGSMASVAFHLNTQLNNGESPKLFEGSENFKRDFVYVGDVADVNLWFLENGVSGIFNLGTGRAESFQAVADATLAYHKKGQIEYIPFPDKLKGRYQAFTQADLTNLRAAGYDKPFKTVAEGVTEYMAWLNRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A09</accession>
    <name>Q32A09_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Uridine phosphorylase</fullName>
            <ecNumber evidence="5 10">2.4.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">udp</name>
        <name evidence="12" type="ordered locus">SDY_3912</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.3" evidence="5 10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000045180.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405337.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A09"/>
    <dbReference type="STRING" id="300267.SDY_3912"/>
    <dbReference type="EnsemblBacteria" id="ABB63846">
        <property type="protein sequence ID" value="ABB63846"/>
        <property type="gene ID" value="SDY_3912"/>
    </dbReference>
    <dbReference type="GeneID" id="66672261"/>
    <dbReference type="KEGG" id="sdy:SDY_3912"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4620"/>
    <dbReference type="HOGENOM" id="CLU_068457_0_0_6"/>
    <dbReference type="OMA" id="MSDVFHL"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010058">
        <property type="entry name" value="Uridine_phosphorylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01718">
        <property type="entry name" value="Uridine-psphlse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="11">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="253" mass="27150" checksum="7446DE45BA1BE58D" modified="2005-12-06" version="1">MSKSDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPVKLASHREFTTWRAELDGKPVIVCSTGIGGPSTSIAVEELAQLGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGASLHFAPLEFPAVADFECTTALVEAAKSIGATTHVGVTASSDTFYPGQERYDTYSGRVVRHFKGSMEEWQAMGVMNYEMESATLLTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESQAVKIVVEAARRLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A61</accession>
    <name>FDHE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein FdhE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fdhE</name>
        <name type="ordered locus">SDY_3852</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for formate dehydrogenase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FdhE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000027708.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405285.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A61"/>
    <dbReference type="SMR" id="Q32A61"/>
    <dbReference type="STRING" id="300267.SDY_3852"/>
    <dbReference type="EnsemblBacteria" id="ABB63794">
        <property type="protein sequence ID" value="ABB63794"/>
        <property type="gene ID" value="SDY_3852"/>
    </dbReference>
    <dbReference type="GeneID" id="67417238"/>
    <dbReference type="KEGG" id="sdy:SDY_3852"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4551"/>
    <dbReference type="HOGENOM" id="CLU_055275_0_0_6"/>
    <dbReference type="OMA" id="PKNLYQR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd16341">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00611">
        <property type="entry name" value="FdeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006452">
        <property type="entry name" value="Formate_DH_accessory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37689">
        <property type="entry name" value="PTHR37689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04216">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018296">
        <property type="entry name" value="Format_dh_formtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01562">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000056715" description="Protein FdhE">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00611"/>
        </source>
    </evidence>
    <sequence length="309" mass="34689" checksum="18E5A447B78C7D77" modified="2005-12-06" version="1">MSIRIIPQDELGSSEKRTADMIPPLLFPRLKNLYNRRAERLRELAENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTARIKEASAQGKPPLDIHVLPRDKHWQKLLMALIAELKPEMSGPALAVIENLEKASTQELEDMASALFASDFSSVSSDKAPFIWAALSLYWAQMANLIPGKARAEYGEQRQYCPVCGSMPVSSMVQIGTTQGLRYLHCNLCETEWHVVRVKCSNCEQSGKLHYWSLDDEQAAIKAESCDDCGTYLKILYQEKEPKVEAVADDLASLVLDARMEQEGYARSSINPFLFPGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A76</accession>
    <name>Q32A76_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cpxA</name>
        <name evidence="12" type="ordered locus">SDY_3835</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000580430.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405270.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A76"/>
    <dbReference type="STRING" id="300267.SDY_3835"/>
    <dbReference type="EnsemblBacteria" id="ABB63779">
        <property type="protein sequence ID" value="ABB63779"/>
        <property type="gene ID" value="SDY_3835"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3835"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4529"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_27_6"/>
    <dbReference type="OMA" id="ANDLLWW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032404">
        <property type="entry name" value="CpxA_peri"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038515">
        <property type="entry name" value="CpxA_peri_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16527">
        <property type="entry name" value="CpxA_peri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="184"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="245"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="457" mass="51600" checksum="3B222714BF8D7DDC" modified="2005-12-06" version="1">MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLVRPASSSQSDFINLLFDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETLKANQLWGEVLDNAAFEAEQMGKSFSVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AB7</accession>
    <name>Q32AB7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">argC</name>
        <name evidence="7" type="ordered locus">SDY_3793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000935386.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405229.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AB7"/>
    <dbReference type="STRING" id="300267.SDY_3793"/>
    <dbReference type="EnsemblBacteria" id="ABB63738">
        <property type="protein sequence ID" value="ABB63738"/>
        <property type="gene ID" value="SDY_3793"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3793"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4482"/>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_6"/>
    <dbReference type="OMA" id="PHLTPMI"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="334" mass="36008" checksum="9C20BE686E474DC1" modified="2005-12-06" version="1">MLNTLIVGASGYAGAELVTYVNRHPHMNITALTVSAQSNDAGKLISDLHPQLKGIVELPLQPMSDISEFSLGVDVVFLATAHEVSHDLAPQFLEAGCVVFDLSGAFRVNDATFYEKYYGFTHQYPELLEQAAYGLAEWSGNKLKEANLIAVPGCYPTAAQLALKPLIDADLLDLNQWPVINATSGVSGAGRKALISNSFCEVSLQPYGVFTHRHQPEIATHLGADVIFTPHLGNFPRGILETITCRLKSGVTQAQVAQVLQQAYAHKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHLIIVATEDNLLKGAAAQAVQCANIRFGYAETQSLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AF9</accession>
    <name>RPOB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="1">RNAP subunit beta</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoB</name>
        <name type="ordered locus">SDY_3741</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005015893.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405187.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AF9"/>
    <dbReference type="SMR" id="Q32AF9"/>
    <dbReference type="STRING" id="300267.SDY_3741"/>
    <dbReference type="EnsemblBacteria" id="ABB63696">
        <property type="protein sequence ID" value="ABB63696"/>
        <property type="gene ID" value="SDY_3741"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3741"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4436"/>
    <dbReference type="HOGENOM" id="CLU_000524_4_3_6"/>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000224106" description="DNA-directed RNA polymerase subunit beta">
        <location>
            <begin position="1"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="1022"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <sequence length="1342" mass="150646" checksum="928492F4C54AB10D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AH8</accession>
    <name>Q32AH8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">purD</name>
        <name evidence="11" type="ordered locus">SDY_3721</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000866815.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405168.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AH8"/>
    <dbReference type="STRING" id="300267.SDY_3721"/>
    <dbReference type="EnsemblBacteria" id="ABB63677">
        <property type="protein sequence ID" value="ABB63677"/>
        <property type="gene ID" value="SDY_3721"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3721"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4412"/>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_6"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="109"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="429" mass="45873" checksum="B8F01A7416940E00" modified="2005-12-06" version="1">MKVLVIGNGGREHALAWKAAQSPLVETVFVAPGNAGTALEPALQNVAIGVTDIPALLDFAQNEKIDLTIVGPEAPLVKGVVDTFRAAGLKIFGPTAGAAQLEGSKAFTKDFLARHKIPTAEYQNFTEVEPALAYLREKGAPIVIKADGLAAGKGVIVAMTLEEAEAAVHDMLAGNAFGDAGHRIVIEEFLDGEEASFIVMVDGEHVLPMATSQDHKRVGDKDTGPNTGGMGAYSPAPVVTDEVHQRTMERIIWPTVKGMAAEGNTYTGFLYAGLMIDKQGNPKVIEFNCRFGDPETQPIMLRMKSDLVELCLAACEGKLDEKTSEWDKRTSLGVVMAAGGYPGDYRTGDVIHGLPLEEVAGGKVFHAGTKLADDEQVVTSGGRVLCVTALGHTVAEAQKCAYALMTDIHWDDCFCRKDIGWRAIEREQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AJ8</accession>
    <name>Q32AJ8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ordered locus">SDY_3693</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000816270.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405148.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AJ8"/>
    <dbReference type="STRING" id="300267.SDY_3693"/>
    <dbReference type="EnsemblBacteria" id="ABB63657">
        <property type="protein sequence ID" value="ABB63657"/>
        <property type="gene ID" value="SDY_3693"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3693"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4381"/>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_6"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB63657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="225" mass="24501" checksum="C9229D2E0DC172BF" modified="2005-12-06" version="1">MKQYLIAPSILSADFARLGEDTAKALAAGADVVHFDVMDNHYVPNLTIGPMVLKSLCNYGITAPIDVHLMVKPVDRIVPDFAAAGASIITFHPEASEHVDRTLQLIKENGCKAGLVFNPATPLSYLDYVMDKLDVILLMSVNPGFGGQSFIPQTLDKLREVRRRIDESGFDIRLEVDGGVKVNNIGEIAAAGADMFVAGSAIFDQPDYKKVIDEMRSELAKVSHE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B02</accession>
    <name>TSGA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein TsgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsgA</name>
        <name type="ordered locus">SDY_3526</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. TsgA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000185230.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404994.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B02"/>
    <dbReference type="SMR" id="Q32B02"/>
    <dbReference type="STRING" id="300267.SDY_3526"/>
    <dbReference type="EnsemblBacteria" id="ABB63503">
        <property type="protein sequence ID" value="ABB63503"/>
        <property type="gene ID" value="SDY_3526"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3526"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4180"/>
    <dbReference type="HOGENOM" id="CLU_056916_0_0_6"/>
    <dbReference type="OMA" id="RFGFVLM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01044">
        <property type="entry name" value="MFS_TsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023528">
        <property type="entry name" value="MFS_TsgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000064253" description="Protein TsgA">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01044"/>
        </source>
    </evidence>
    <sequence length="393" mass="43152" checksum="682C1526AA1E2A14" modified="2005-12-06" version="1">MTNSNRIKLTWISFLSYALTGALVIVTGMVMGNIADYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFLLMVLAVAGLMFSHSLALFSAAMFILGVVSGITMSIGTFLITQMYEGRQRGSRLLFTDSFFSMAGMIFPMIAAFLLARSIEWYWVYACIGLVYVAIFILTFGCEFPALGKHAPKTDAPVAKEKWGIGVLFLSVAALCYILGQLGFISWVPEYAKGLGMSLNDAGTLVSNFWMSYMVGMWAFSFILRFFDLQRILTVLAGLAAILMYVFNTGTPAHMAWSILTLGFFSSAIYTTIITLGSQQTKVPSPKLVNFVLTCGTIGTMLTFVVTGPIVEHSGPQAALLTANGLYAVVFVMCFLLGFVSRHRQHNTLTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B58</accession>
    <name>Q32B58_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1992 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdN</name>
        <name evidence="2" type="ordered locus">SDY_3469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000266494.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404938.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B58"/>
    <dbReference type="STRING" id="300267.SDY_3469"/>
    <dbReference type="EnsemblBacteria" id="ABB63447">
        <property type="protein sequence ID" value="ABB63447"/>
        <property type="gene ID" value="SDY_3469"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3469"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4122"/>
    <dbReference type="HOGENOM" id="CLU_129296_0_0_6"/>
    <dbReference type="OMA" id="AQTKGEF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DUF1992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1992" evidence="1">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="122" mass="14000" checksum="E79896071342EDF3" modified="2005-12-06" version="1">MWLLDQWAERHIAEAQAKGEFDNLAGSGEPLILDDDSHVPPELRAGYRLLKNAGCLPPELEQRREAIQLLDILRGIRHDEPQYQEVSRRLSLLELKLRQAGLSTDFLRGDYADKLLNKINEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B71</accession>
    <name>Q32B71_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yhdY</name>
        <name evidence="11" type="ordered locus">SDY_3447</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404925.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B71"/>
    <dbReference type="STRING" id="300267.SDY_3447"/>
    <dbReference type="EnsemblBacteria" id="ABB63434">
        <property type="protein sequence ID" value="ABB63434"/>
        <property type="gene ID" value="SDY_3447"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3447"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4106"/>
    <dbReference type="HOGENOM" id="CLU_019602_16_1_6"/>
    <dbReference type="OMA" id="LVFWVFC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="160"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="368" mass="41608" checksum="E45E2B4D77B95085" modified="2005-12-06" version="1">MMTKVLLSHPSRPASHNSSRAMVWVRKNLFSSWSNSLLTIGCIWLMWELIPPLLNWAFLQANWVGSTRADCTKAGACWVFIHERFGQFMYGLYPHDQRWRINLALLIGLVSIAPMFWKILPHRGRYIALWAVIYPLIVWWLMYGGFFALDRVETRQWGGLTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVLFMSSVMLPLFMAEGTSIDKLIRALVGVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLFSSVQQATVDPAWLGMSTEGYVFAALIYWIFCFSMSRYSQHLEKRFNTGRTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B80</accession>
    <name>Q32B80_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/pantothenate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">panF</name>
        <name evidence="11" type="ordered locus">SDY_3435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B80"/>
    <dbReference type="STRING" id="300267.SDY_3435"/>
    <dbReference type="EnsemblBacteria" id="ABB63425">
        <property type="protein sequence ID" value="ABB63425"/>
        <property type="gene ID" value="SDY_3435"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3435"/>
    <dbReference type="HOGENOM" id="CLU_018808_15_1_6"/>
    <dbReference type="OMA" id="GWWGMRR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10327">
        <property type="entry name" value="SLC5sbd_PanF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011849">
        <property type="entry name" value="Na/pantothenate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02119">
        <property type="entry name" value="panF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="485" mass="51979" checksum="8A75D3B43D082AE8" modified="2005-12-06" version="1">MTMQLEVILPLVAYLVVVFGISVYAMRKRSTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLAMIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGTMTVQFIGGARLLETAAGIPYETGLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTVVLLIGVVHAAGGLSNAVQTLQTIDPQLVTPQGADDILSPAFMTSFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGLIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLVLGALLLLAAWKPPEMIIWLNLLAFGGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLATLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQATVLTTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BB9</accession>
    <name>Q32BB9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhcG</name>
        <name evidence="3" type="ordered locus">SDY_3395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000445143.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404877.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BB9"/>
    <dbReference type="STRING" id="300267.SDY_3395"/>
    <dbReference type="EnsemblBacteria" id="ABB63386">
        <property type="protein sequence ID" value="ABB63386"/>
        <property type="gene ID" value="SDY_3395"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3395"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4051"/>
    <dbReference type="HOGENOM" id="CLU_046640_1_1_6"/>
    <dbReference type="OMA" id="LTHQDVG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009362">
        <property type="entry name" value="YhcG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041527">
        <property type="entry name" value="YhcG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17761">
        <property type="entry name" value="DUF1016_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06250">
        <property type="entry name" value="YhcG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1016_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="YhcG_C" evidence="1">
        <location>
            <begin position="208"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="375" mass="43453" checksum="85175EA9DA7E5B21" modified="2005-12-06" version="1">MESLSERTSTGYQQIHDGIIHLVDSARTETVRSVNALMTATYWEIGRRIVEFEQGGEARAAYGAQLIKRLSKDLSLRYKRGFSAKNLRQMRLFYLFFQHVEIRQTVSGELTPLGIPQTPSAEFPSAKIWQTLSAKSFPLPWSTYVRLLSVKNADARSFYEKETLRCGWSVRQLERQIATQFYERTLLSHDKSAMLQQHAPAETHILPQQAIRDPFVLEFLELKDEYSESDFEEALINHLMDFMLELGDDFAFVGRQRRLRIDDNWFRVDLLFFHRRLRCLLIVDLKVGKFSYSDAGQMNMYLNYAKEHWTLPDENPPIGLVLCAEKGVGEAHYALAGLPNTVLASEYKMQLPDEKRLADELVRTQAVLEEGYRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BJ8</accession>
    <name>Q32BJ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Threonine dehydratase operon activator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tdcR</name>
        <name evidence="1" type="ordered locus">SDY_3311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000145851.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404798.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BJ8"/>
    <dbReference type="EnsemblBacteria" id="ABB63307">
        <property type="protein sequence ID" value="ABB63307"/>
        <property type="gene ID" value="SDY_3311"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3311"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3957"/>
    <dbReference type="HOGENOM" id="CLU_2069389_0_0_6"/>
    <dbReference type="OMA" id="HDRTSFC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="114" mass="13610" checksum="0B561D2520C6DB85" modified="2005-12-06" version="1">MTGITIFYGDNIIRYVVNTKKGLRPYFKQLPDNYQEKFELNLMSKFSNFIINKPFSAINNAARHIFSRYLLENKHLFYQYFKISNTGINHLEQLINVNFFSSDRTSFCECNRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BM9</accession>
    <name>Q32BM9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport of hexuronates</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">exuT</name>
        <name evidence="8" type="ordered locus">SDY_3278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404767.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BM9"/>
    <dbReference type="STRING" id="300267.SDY_3278"/>
    <dbReference type="EnsemblBacteria" id="ABB63276">
        <property type="protein sequence ID" value="ABB63276"/>
        <property type="gene ID" value="SDY_3278"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3278"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3920"/>
    <dbReference type="HOGENOM" id="CLU_001265_5_1_6"/>
    <dbReference type="OMA" id="FYKHPKD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="51"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="472" mass="51744" checksum="DA246323CF2788AC" modified="2005-12-06" version="1">MATFGACRFFFGYPVVTNIFSLWRDDGRASCRYNKTMRFYMRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSERFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISSALSFIWAMAWLIFYKHPRDQKHLTDEERDYIINGQEAQHQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNRKEIAMFAWMPMLFADLGCILGSYLPPLFQRWFGVNLIVSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIWTVLQNKPAIEVAQETHNDPAPQH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BN2</accession>
    <name>SSTT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine transporter SstT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Na(+)/serine-threonine symporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sstT</name>
        <name type="ordered locus">SDY_3274</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29575"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:29577"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69999"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:70001"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000211639.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404764.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BN2"/>
    <dbReference type="SMR" id="Q32BN2"/>
    <dbReference type="STRING" id="300267.SDY_3274"/>
    <dbReference type="EnsemblBacteria" id="ABB63273">
        <property type="protein sequence ID" value="ABB63273"/>
        <property type="gene ID" value="SDY_3274"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3274"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3915"/>
    <dbReference type="HOGENOM" id="CLU_044581_0_0_6"/>
    <dbReference type="OMA" id="PVNLQLC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032329">
        <property type="term" value="P:serine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015826">
        <property type="term" value="P:threonine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01582">
        <property type="entry name" value="Ser_Thr_transp_SstT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023025">
        <property type="entry name" value="Ser_Thr_transp_SstT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0769">Symport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000309130" description="Serine/threonine transporter SstT">
        <location>
            <begin position="2"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="2"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="37"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="353"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01582"/>
        </source>
    </evidence>
    <sequence length="414" mass="43435" checksum="4E0A956BEF72B9C0" modified="2005-12-06" version="1">MTTQRSPGLFRRLAHGSLVKQILVGLVLGILLAWISKPAAEAVGLLGTLFVGALKAVAPILVLMLVMASIANHQHGQKTNILPILFLYLLGTFSAALAAVVFSFAFPSTLHLSSSAGDISPPSGIVEVMRGLVMSMVSNPIDALLKGNYIGILVWAIGLGFALRHGNETTKNLVNDMSNAVTFMVKLVIRFAPIGIFGLVSSTLATTGFSTLWGYAQLLVVLVGCMLLVALVVNPLLVWWKIRRNPFPLVLLCLRESGVYAFFTRSSAANIPVNMALCEKLNLDRDTYSVSIPLGATINMAGAAITITVLTLAAVNTLGIPVDLPTALLLSVVASLCACGASGVAGGSLLLIPLACNMFGISNDIAMQVVAVGFIIGVLQDSCETALNSSTDVLFTAAACQAEDDRLANSALRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BP7</accession>
    <name>Q32BP7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yqjI</name>
        <name evidence="3" type="ordered locus">SDY_3255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000017998.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404749.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BP7"/>
    <dbReference type="STRING" id="300267.SDY_3255"/>
    <dbReference type="EnsemblBacteria" id="ABB63258">
        <property type="protein sequence ID" value="ABB63258"/>
        <property type="gene ID" value="SDY_3255"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3255"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3889"/>
    <dbReference type="HOGENOM" id="CLU_063440_1_0_6"/>
    <dbReference type="OMA" id="IADKPSH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="67"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="207" mass="23387" checksum="AA3EE342BCE082F7" modified="2005-12-06" version="1">MSHHHEGCCKHEGQPRHEGCCKGEKSEHEHCGHGHQHEHGQCCGGRHGRGGGRRQRFFGHGELRLVILDILSRDDSHGYELIKAIENLTQGNYTPSPGVIYPTLDFLQEQSLITIREEEGGKKQIALTEQGAQWLEENREQVEMIEERIKARCVGAALRQNPQMKQALDNFKAVLDLRVNQSDITDAQIKKIIAVIDRAAFDITQLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BQ8</accession>
    <name>CCA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Multifunctional CCA protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">CCA-adding enzyme</fullName>
                <ecNumber evidence="1">2.7.7.72</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">CCA tRNA nucleotidyltransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">tRNA CCA-pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">tRNA adenylyl-/cytidylyl-transferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">tRNA nucleotidyltransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">tRNA-NT</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">2'-nucleotidase</fullName>
                <ecNumber evidence="1">3.1.3.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">2',3'-cyclic phosphodiesterase</fullName>
                <ecNumber evidence="1">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Phosphatase</fullName>
                <ecNumber evidence="1">3.1.3.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">cca</name>
        <name type="ordered locus">SDY_3239</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Magnesium is required for nucleotidyltransferase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="1">Nickel for phosphatase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Can also form homodimers and oligomers.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="1"/>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000708467.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BQ8"/>
    <dbReference type="SMR" id="Q32BQ8"/>
    <dbReference type="STRING" id="300267.SDY_3239"/>
    <dbReference type="EnsemblBacteria" id="ABB63247">
        <property type="protein sequence ID" value="ABB63247"/>
        <property type="gene ID" value="SDY_3239"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3239"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3868"/>
    <dbReference type="HOGENOM" id="CLU_015961_1_1_6"/>
    <dbReference type="OMA" id="GWTFHGH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004112">
        <property type="term" value="F:cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01261">
        <property type="entry name" value="CCA_bact_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01262">
        <property type="entry name" value="CCA_bact_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012006">
        <property type="entry name" value="CCA_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000813">
        <property type="entry name" value="CCA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0692">RNA repair</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000054300" description="Multifunctional CCA protein">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="228"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01175"/>
        </source>
    </evidence>
    <sequence length="412" mass="46548" checksum="C64D86937391179D" modified="2005-12-06" version="1">MKIYLVGGAVRDALLGLPVKDRDWVVVGSTPQEMLDAGYHQVGRDFPVFLHPQTHEEYALARTERKSGSGYTGFTCYAAPDVTLEDDLKRRDLTINALAQDDNGEIIDPYNGLGDLQNRLLRHVSPAFGEDPLRVLRVARFAARYAHLVFRIADETLTLMREMTHAGELEHLTPERVWKETESALTTRNPQVFFQVLRDCGALRVLFPEIDALFGVPAPAKWHPEIDTGIHTLMTLSMAAMLSPQVDVRFATLCHDLGKGLTPPELWPRHHGHGPAGVKLVEQLCQRLRVPNEIRDLARLVAEFHDLIHTFPMLNPKTIVKLFDSIDAWRKPQRVEQLALTSEADVRGRTGFESADYPQGRWLREAWEVAQSVPTKAVVEAGFKGVEIREELTRRRIAAVASWKEQRCPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C23</accession>
    <name>Q32C23_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="7">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="7">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yggV</name>
        <name evidence="9" type="ordered locus">SDY_3118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001174741.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404623.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C23"/>
    <dbReference type="STRING" id="300267.SDY_3118"/>
    <dbReference type="EnsemblBacteria" id="ABB63132">
        <property type="protein sequence ID" value="ABB63132"/>
        <property type="gene ID" value="SDY_3118"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3118"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3728"/>
    <dbReference type="HOGENOM" id="CLU_082080_0_3_6"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="154"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="197" mass="20958" checksum="7BE8BECE11AB2BCA" modified="2005-12-06" version="1">MQKVVLATGNAGKVRELASLLSDFGLDIVAQTDLGVDSAEETGLTFIENAILKARHAAKVTGLPAIADDSGLAVDVLGGAPGIYSARYSGEDATDLKNLQKLLETLKDVPDDQRQARFHCVLVYLRHAEDPTPLVCHGSWPGVITREPAGTGGFGYDPIFFVPSEGKNAAELTHEEKSAISHRGQALKLLLDALRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CB0</accession>
    <name>Q32CB0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Positive regulator of gcv operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvA</name>
        <name evidence="3" type="ordered locus">SDY_3026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000044393.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404536.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CB0"/>
    <dbReference type="STRING" id="300267.SDY_3026"/>
    <dbReference type="EnsemblBacteria" id="ABB63045">
        <property type="protein sequence ID" value="ABB63045"/>
        <property type="gene ID" value="SDY_3026"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3026"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3632"/>
    <dbReference type="HOGENOM" id="CLU_039613_37_0_6"/>
    <dbReference type="OMA" id="IAIYYGK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="305" mass="34418" checksum="EA6A954791AB42B3" modified="2005-12-06" version="1">MSKRLPPLNALRVFDAAARHLSFTRAAEELFVTQAAVSHQIKSLEDFLGLKLFRRRNRSLLLTEEGQSYFLDIKEIFSQLTEATRKLQARSAKGALTVSLLPSFAIHWLVPRLSSFNSAYPGIDVRIQAVDRQEDKLADDVDVAIFYGRGNWLGLRVEKLYAEYLLPVCSPLLLTGEKPLKTPEDLAKHTLLHDASRRDWQTYTRQLGLNHINVQQGPIFSHSAMVLQAAIHGQGVALANNVMAQSEIEAGRLVCPFNDVLVSKNAFYLVCHDSQAELGKIAAFRQWILAKAAAEQEKFRFRYEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CD0</accession>
    <name>RLMD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD</fullName>
            <ecNumber evidence="2">2.1.1.190</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">23S rRNA(m5U1939)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rlmD</name>
        <name type="synonym">rumA</name>
        <name type="ordered locus">SDY_3002</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-adenosyl-L-methionine + uridine(1939) in 23S rRNA = 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10278"/>
            <dbReference type="Rhea" id="RHEA-COMP:10279"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.190"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.190" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000046834.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404516.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CD0"/>
    <dbReference type="SMR" id="Q32CD0"/>
    <dbReference type="STRING" id="300267.SDY_3002"/>
    <dbReference type="EnsemblBacteria" id="ABB63025">
        <property type="protein sequence ID" value="ABB63025"/>
        <property type="gene ID" value="SDY_3002"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3002"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3601"/>
    <dbReference type="HOGENOM" id="CLU_014689_8_2_6"/>
    <dbReference type="OMA" id="FYAGDMK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070041">
        <property type="term" value="F:rRNA (uridine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01010">
        <property type="entry name" value="23SrRNA_methyltr_RlmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001566">
        <property type="entry name" value="23S_rRNA_MeTrfase_RlmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000229884" description="23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD">
        <location>
            <begin position="2"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01010"/>
        </source>
    </evidence>
    <sequence length="433" mass="48118" checksum="941195B56697A45A" modified="2005-12-06" version="1">MAQFYSAKRRTTTRQIITVSVNDLDSFGQGVARHNGKTLFIPGLLSQENAEVTVTEDKKQYARAKVVRRLSDSPERETPRCPHFGVCGGCQQQHASVDLQQRSKSAALARLMKHEVSEVIADVPWGYRRRARLSLNYLPKTQQLQMGFRKAGSSDIVDVKQCPILVPQLEALLPKVRACLGSLQAMRHLGHVELVQATSGTLMILRHTAPLSSADREKLERFSHSEGLDLYLAPDSEIFETVSGEMPWYDSNGLRLTFSPRDFIQVNAGVNQKMVARALEWLDVQPEDRVLDLFCGMGNFTLPLATQAASVVGVEGVPALVEKGQQNARLNGLQNVTFYHENLEEDVTKQPWAKNGFDKVLLDPARAGAAGVMQQIIKLEPIRIVYVSCNPATLARDSEALLKAGYTIARLAMLDMFPHTGHLESMVLFSRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CD2</accession>
    <name>Q32CD2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PemI-like suppressor of inhibitory function of ChpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">chpR</name>
        <name evidence="3" type="ordered locus">SDY_3000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000581937.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404514.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CD2"/>
    <dbReference type="SMR" id="Q32CD2"/>
    <dbReference type="STRING" id="300267.SDY_3000"/>
    <dbReference type="EnsemblBacteria" id="ABB63023">
        <property type="protein sequence ID" value="ABB63023"/>
        <property type="gene ID" value="SDY_3000"/>
    </dbReference>
    <dbReference type="GeneID" id="66673350"/>
    <dbReference type="KEGG" id="sdy:SDY_3000"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3599"/>
    <dbReference type="HOGENOM" id="CLU_150554_1_0_6"/>
    <dbReference type="OMA" id="WGNSPSV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="9356" checksum="CD452A9AA4FB362E" modified="2005-12-06" version="1">MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKEVW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CD6</accession>
    <name>ENO_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enolase</fullName>
            <ecNumber evidence="2">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eno</name>
        <name type="ordered locus">SDY_2996</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <text evidence="2">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000036723.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404510.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CD6"/>
    <dbReference type="SMR" id="Q32CD6"/>
    <dbReference type="STRING" id="300267.SDY_2996"/>
    <dbReference type="EnsemblBacteria" id="ABB63019">
        <property type="protein sequence ID" value="ABB63019"/>
        <property type="gene ID" value="SDY_2996"/>
    </dbReference>
    <dbReference type="GeneID" id="67413943"/>
    <dbReference type="KEGG" id="sdy:SDY_2996"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3595"/>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_6"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000267105" description="Enolase">
        <location>
            <begin position="2"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="2">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="369"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <sequence length="432" mass="45655" checksum="0569036E87471B91" modified="2005-12-06" version="1">MSKIVKIIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVAAVNGPIAQALIGKDAKDQAGIDKIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYEHIAELNGTPGKYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTVKEAIRMGSEVFHHLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEELTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CH4</accession>
    <name>Q32CH4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000281401.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404472.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CH4"/>
    <dbReference type="STRING" id="300267.SDY_2955"/>
    <dbReference type="EnsemblBacteria" id="ABB62981">
        <property type="protein sequence ID" value="ABB62981"/>
        <property type="gene ID" value="SDY_2955"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2955"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3547"/>
    <dbReference type="HOGENOM" id="CLU_080982_0_0_6"/>
    <dbReference type="OMA" id="HDVVMDA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010179">
        <property type="entry name" value="CRISPR-assoc_prot_Cse3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08798">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01101">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01907">
        <property type="entry name" value="casE_Cse3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="199" mass="22348" checksum="6B876A7DDEACE715" modified="2005-12-06" version="1">MYLSKVIIARAWSRDLYQLHQGLWHLFPNRPDAARDFLFHVEKRNTPEGCHVLLQSAQMPVSTAVATVIKTKQVEFQLQVGVPLYFRLRANPIKTILDNQKRLDSKGNIKRCRVPLIKEAEQIAWLQRKLGNAARVEDVHPISERPQYFSGEGKNGKIQTVCFEGVLTINDAPALIDLLQQGIGPAKSMGCGLLSLAPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CI0</accession>
    <name>CYSC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysC</name>
        <name type="ordered locus">SDY_2949</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001173673.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404466.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CI0"/>
    <dbReference type="SMR" id="Q32CI0"/>
    <dbReference type="STRING" id="300267.SDY_2949"/>
    <dbReference type="EnsemblBacteria" id="ABB62975">
        <property type="protein sequence ID" value="ABB62975"/>
        <property type="gene ID" value="SDY_2949"/>
    </dbReference>
    <dbReference type="GeneID" id="66673376"/>
    <dbReference type="KEGG" id="sdy:SDY_2949"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3541"/>
    <dbReference type="HOGENOM" id="CLU_046932_1_0_6"/>
    <dbReference type="OMA" id="GVTIWFT"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000009032" description="Adenylyl-sulfate kinase">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <sequence length="201" mass="22321" checksum="11E15BB8F9D2FD4B" modified="2005-12-06" version="1">MALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTYLLDGDNVRHGLCSDLGFSDADRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRERVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFTGIDSVYEAPESAEIHLNGEQLVTNLVQQLLDLLRQNDIIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CS7</accession>
    <name>Q32CS7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS4 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0793</name>
        <name evidence="4" type="ordered locus">SDY_2839</name>
        <name evidence="5" type="ordered locus">SDY_4335</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000483776.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402464.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404369.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405718.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0793"/>
    <dbReference type="EnsemblBacteria" id="ABB60975">
        <property type="protein sequence ID" value="ABB60975"/>
        <property type="gene ID" value="SDY_0793"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62878">
        <property type="protein sequence ID" value="ABB62878"/>
        <property type="gene ID" value="SDY_2839"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64227">
        <property type="protein sequence ID" value="ABB64227"/>
        <property type="gene ID" value="SDY_4335"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0793"/>
    <dbReference type="KEGG" id="sdy:SDY_2839"/>
    <dbReference type="KEGG" id="sdy:SDY_4335"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3412"/>
    <dbReference type="HOGENOM" id="CLU_028400_1_1_6"/>
    <dbReference type="OMA" id="TWGSERY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024473">
        <property type="entry name" value="Transposases_IS4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13006">
        <property type="entry name" value="Nterm_IS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nterm_IS4" evidence="2">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="448" mass="51156" checksum="6CC125C4569C49EB" modified="2005-12-06" version="1">MFPDFFMHIGQALDLVSRYDSLRNPLTSLGDYLDPELISRCLAESGTVTLRKRRLPLEMMVWCIVGMVLERKEPLHQIVNRLDIMLPGNRPFVAPSAVIQARQRLGSEAVRRVFTKTAQLWHNATPHPHWCGLTLLAIDGVFWRTPDTPENDAAFPRQTHAGNPALYPQVKMVCQMELTSHLLTAAAFGTMKNSENELAEQLIEQTGDNTLTLMDKGYYSLGLLNGWSLAGEHRHWMIPLRKGAQYEELRKLGKGDHLVKLKTSPQARKKWPGLGNEVTARLLTVTRKGKVCHLLTSMTDAMRFPGGEMADLYSHRWEIELGYREIKQTMQLSRLTLRSKKPELVEQELWGVLLAYNLVRYQMIKMAEHLKGYWPNQLSFSESCGMVMRMLMTLQGASPGRIPELMRDLASMGQLVKLPTRRERAFPRVVKERPWKYPTAPKKSQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CV0</accession>
    <name>Q32CV0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulates activity of sigma-E factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rseB</name>
        <name evidence="8" type="ordered locus">SDY_2812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RseB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000812053.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404346.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CV0"/>
    <dbReference type="SMR" id="Q32CV0"/>
    <dbReference type="STRING" id="300267.SDY_2812"/>
    <dbReference type="EnsemblBacteria" id="ABB62855">
        <property type="protein sequence ID" value="ABB62855"/>
        <property type="gene ID" value="SDY_2812"/>
    </dbReference>
    <dbReference type="GeneID" id="66673540"/>
    <dbReference type="KEGG" id="sdy:SDY_2812"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3387"/>
    <dbReference type="HOGENOM" id="CLU_054710_1_0_6"/>
    <dbReference type="OMA" id="DDFRYQY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd16327">
        <property type="entry name" value="RseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033436">
        <property type="entry name" value="MucB/RseB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038484">
        <property type="entry name" value="MucB/RseB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033434">
        <property type="entry name" value="MucB/RseB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005588">
        <property type="entry name" value="MucB_RseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38782">
        <property type="entry name" value="PTHR38782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03888">
        <property type="entry name" value="MucB_RseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17188">
        <property type="entry name" value="MucB_RseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005427">
        <property type="entry name" value="RseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220899" evidence="5">
        <location>
            <begin position="24"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="MucB_RseB" evidence="6">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="MucB_RseB_C" evidence="7">
        <location>
            <begin position="217"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="318" mass="35750" checksum="3F8C34DD85600B54" modified="2005-12-06" version="1">MKQLWFAMSLVTGSLLFSANASATPASGALLQQMNLASQSLNYELSFISINKQGVESLRYRHARLDNRPLAQLLQMDGPRREVVQRGNEISYFEPGLEPFTLNGDYIVDSLPSLIYTDFKRLSPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYIVWMDTESKLPMRVDLLDRDGETLEQFRVIAFNVNQDISSSMQTLAKANLPPLLSVPVGEKAKFSWTPTWLPQGFSEVSSSRRPLPTMDNMPIESRLYSDGLFSFSVNVNRATPSSTDQMLRTGRRTVSTSVRDNAEITIVGELPPQTAKRIAENIKFGAAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CV7</accession>
    <name>PDXJ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxine 5'-phosphate synthase</fullName>
            <shortName evidence="1">PNP synthase</shortName>
            <ecNumber evidence="1">2.6.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxJ</name>
        <name type="ordered locus">SDY_2805</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="EC" id="2.6.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.99.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005017178.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404339.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CV7"/>
    <dbReference type="SMR" id="Q32CV7"/>
    <dbReference type="STRING" id="300267.SDY_2805"/>
    <dbReference type="EnsemblBacteria" id="ABB62848">
        <property type="protein sequence ID" value="ABB62848"/>
        <property type="gene ID" value="SDY_2805"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2805"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3380"/>
    <dbReference type="HOGENOM" id="CLU_074563_0_0_6"/>
    <dbReference type="OMA" id="SNAGWDT"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033856">
        <property type="term" value="F:pyridoxine 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00003">
        <property type="entry name" value="PNPsynthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00279">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004569">
        <property type="entry name" value="PyrdxlP_synth_PdxJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036130">
        <property type="entry name" value="Pyridoxine-5'_phos_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456">
        <property type="entry name" value="PTHR30456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03740">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63892">
        <property type="entry name" value="SSF63892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00559">
        <property type="entry name" value="pdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000231846" description="Pyridoxine 5'-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00279"/>
        </source>
    </evidence>
    <sequence length="243" mass="26399" checksum="B0A21072844E969B" modified="2005-12-06" version="1">MAELLLGVNIDHIATLRNARGTAYPDPVQAAFIAEQAGADGITVHLREDRRHITDRDVRILRQTLDTRMNLEMAVTEEMLAIAVETKPHFCCLVPEKRQEVTTEGGQDVAGQRDKMRDACKRLADAGIQVSLFIDADEEQIKAAAEVGAPFIEIHTGCYADAKTDAEQAQELARIAKAATFAASLGLKVNAGHGLTYHNVKAIAAIPEMHELNIGHAIIGRAVMTGLKDAVAEMKRLMLEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CW3</accession>
    <name>Q32CW3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CW3"/>
    <dbReference type="EnsemblBacteria" id="ABB62842">
        <property type="protein sequence ID" value="ABB62842"/>
        <property type="gene ID" value="SDY_2799"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2799"/>
    <dbReference type="HOGENOM" id="CLU_1638923_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="170" mass="19708" checksum="5402BD36E2CDA66A" modified="2005-12-06" version="1">MRGAMKTQKAFRLPITPEIRRIIDEQKAWRDSVPECNRDYVFLQPRDPMQPFSKRSLDKLVKTYSPDGAVKGIKHDGTVKGKDGAFNTMCRKFLKSNVIALMKERGYSRSDRREISLLCLHHTSKSDDPMAEHYDFSDEILQEEIALKREAFEAHERSILAQVALLRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D83</accession>
    <name>Q32D83_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase 4 membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hyfB</name>
        <name evidence="4" type="ordered locus">SDY_2671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000339453.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404213.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D83"/>
    <dbReference type="STRING" id="300267.SDY_2671"/>
    <dbReference type="EnsemblBacteria" id="ABB62722">
        <property type="protein sequence ID" value="ABB62722"/>
        <property type="gene ID" value="SDY_2671"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2671"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3222"/>
    <dbReference type="HOGENOM" id="CLU_007100_8_1_6"/>
    <dbReference type="OMA" id="AMCFVKV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="136"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="672" mass="72569" checksum="34A4BD14DF86875B" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DA8</accession>
    <name>Q32DA8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404188.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DA8"/>
    <dbReference type="EnsemblBacteria" id="ABB62697">
        <property type="protein sequence ID" value="ABB62697"/>
        <property type="gene ID" value="SDY_2644"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2644"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="76" mass="8080" checksum="52C530CBBFADD04A" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITASSSPGCAMRCASVTCLPGTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DN3</accession>
    <name>Q32DN3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yfcI</name>
        <name evidence="3" type="ordered locus">SDY_2502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404063.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DN3"/>
    <dbReference type="EnsemblBacteria" id="ABB62572">
        <property type="protein sequence ID" value="ABB62572"/>
        <property type="gene ID" value="SDY_2502"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2502"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3014"/>
    <dbReference type="HOGENOM" id="CLU_059548_7_0_6"/>
    <dbReference type="OMA" id="ERVPQHK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="206" mass="23801" checksum="363FF38E06803E42" modified="2005-12-06" version="1">MAFRMMRYSIAAMQKHLDAGYKELPLVIPMLFYHGCRSPYPYSLCWLDEFAEPAIARKIYSSAFPLVDITVVPDDEIMQHRKMALLELIQKHIRQRDLLGLVDQIVSLLVTGNTNDRQLKALFNYVLQTGDARRFRAFIGEITERAPQEKEKLMTIADRLREEGAMQGKHEEALRIAQEMLEKGFDHEVILTLTRLSPDDLIAQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DN6</accession>
    <name>Q32DN6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yfcG</name>
        <name evidence="4" type="ordered locus">SDY_2499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000566506.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404060.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DN6"/>
    <dbReference type="STRING" id="300267.SDY_2499"/>
    <dbReference type="EnsemblBacteria" id="ABB62569">
        <property type="protein sequence ID" value="ABB62569"/>
        <property type="gene ID" value="SDY_2499"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2499"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3011"/>
    <dbReference type="HOGENOM" id="CLU_011226_14_4_6"/>
    <dbReference type="OMA" id="SGSIMQY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="90"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="215" mass="24372" checksum="5E658A476C723051" modified="2005-12-06" version="1">MIDLYFAPTPNGHKITLFLEEAGLDYRLIKVDLGKGGQFRPEFLRISPNNKIPAIVDHSPADGGEPLSLFESGAILLYLAEKTGLFLSHGTRERAATLQWLFWQVGGLGPMLGQNHHFNHAAPQTIPYAIERYQVETQRLYHVLNKRLENSPWLGGENYSIADIACWPWVNAWTRQRIDLAMYPAVKNWHERIRSRPATGQALLKAQLGDERSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DN7</accession>
    <name>Q32DN7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfcF</name>
        <name evidence="2" type="ordered locus">SDY_2498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DN7"/>
    <dbReference type="STRING" id="300267.SDY_2498"/>
    <dbReference type="EnsemblBacteria" id="ABB62568">
        <property type="protein sequence ID" value="ABB62568"/>
        <property type="gene ID" value="SDY_2498"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2498"/>
    <dbReference type="HOGENOM" id="CLU_011226_17_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="107" mass="12465" checksum="8A712B12760E1467" modified="2005-12-06" version="1">MSKPAITLWSDAHFFSPYVLSAWVALQEKGLSFHIKTIDLDSGEHLQPTWQGYDQTRRVPLLQIDDFELSESSTIAEYLEDRFAPPTWERIYPLDLENRARARQIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DR1</accession>
    <name>Q32DR1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase I chain L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nuoL</name>
        <name evidence="9" type="ordered locus">SDY_2474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404035.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DR1"/>
    <dbReference type="STRING" id="300267.SDY_2474"/>
    <dbReference type="EnsemblBacteria" id="ABB62544">
        <property type="protein sequence ID" value="ABB62544"/>
        <property type="gene ID" value="SDY_2474"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2474"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2985"/>
    <dbReference type="HOGENOM" id="CLU_007100_6_2_6"/>
    <dbReference type="OMA" id="LIGFWQH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="133"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="613" mass="66381" checksum="2AE165A5F4731926" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DS3</accession>
    <name>Q32DS3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">menF</name>
        <name evidence="6" type="ordered locus">SDY_2461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABB62532">
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        <property type="gene ID" value="SDY_2461"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2461"/>
    <dbReference type="HOGENOM" id="CLU_006493_8_4_6"/>
    <dbReference type="OMA" id="TGHGQSI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044250">
        <property type="entry name" value="MenF-like"/>
    </dbReference>
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        <property type="entry name" value="PTHR47253"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="94"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="356" mass="40316" checksum="86B60B6BEABC5DC9" modified="2005-12-06" version="1">MDQAQRFLRQHPEHADLRIWGLNAFDPSQGNLLLPRLEWRRCGGKATLRLTLFSESSLQHDAINAREFIATLVSIKPLPGLHLTTTREQHWPDKTGWTQLIELATKTIAEGELNKVVLARATDLHFASPVNATAMMAASRRLNLNCYHFYMAFDGENAFLGSSPERLWRRRDKALRTEALAGTVANHPDDKQAQQLGEWLMAADKNQRENMLVVEDICQRLQADTQTLDVLPPQVLRLRKVQHLRRCIWTSLNKADDVICLHQLQPTAAVAGLPRDLARQFIARHEPFTREWYAGSAGYLSLQQSEFCVSLRSAKISGNVVRLYAGAGIVRGSDPEQEWQEIDNKAAGLRTLLQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E26</accession>
    <name>Q32E26_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS4 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378800.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403920.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E26"/>
    <dbReference type="STRING" id="300267.SDY_2352"/>
    <dbReference type="EnsemblBacteria" id="ABB62429">
        <property type="protein sequence ID" value="ABB62429"/>
        <property type="gene ID" value="SDY_2352"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2352"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2837"/>
    <dbReference type="HOGENOM" id="CLU_028400_1_1_6"/>
    <dbReference type="OMA" id="PAEQVVW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024473">
        <property type="entry name" value="Transposases_IS4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13006">
        <property type="entry name" value="Nterm_IS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nterm_IS4" evidence="2">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="448" mass="51098" checksum="381E1DD5A3652B1D" modified="2005-12-06" version="1">MFPDFFMHIGQALDLVSRYDSLRNPLTSLGDYLDPELISRCLAESGTVTLRKRRLPLEMMVWCIVGMALERKEPLHQIVNRLDIMLPGNRPFVAPSAVIQARQRLGSEAVRRVFTKTAQLWHNATPHPHWCGLTLLAIDGVFWRTPDTPENDAAFPRQTHAGNPALYPQVKMVCQMELTSHLLTAAAFGAMKNSENELAEQLIEQTGDNTLSLMDKGYYSLGLLNAWSLAGEHRHWMIPLRKGAQYEEIRKLGKGDHLVKLKTSPQARKKWPGLGNEVTARLLTVTRKGKVCHLLTSMTDAMRFPGGEMADLYSHRWEIELGYREIKQTMQLSRLTLRSKKPELVEQELWGVLLAYNLVRYQMIKMAEHLKGYWPNQLSFSESCGMVMRMLMTLQGASPGRIPELMRDLASMGQLVKLPTRRERAFPRVVKERPWKYPTAPKKSQSVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E73</accession>
    <name>YMDB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">O-acetyl-ADP-ribose deacetylase</fullName>
            <ecNumber evidence="1">3.1.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Regulator of RNase III activity</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ymdB</name>
        <name type="ordered locus">SDY_2305</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59244"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:142723"/>
            <dbReference type="EC" id="3.1.1.106"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)</text>
            <dbReference type="Rhea" id="RHEA:57060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="3.1.1.106"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Interacts with RNase III.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YmdB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.106" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000857417.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403873.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E73"/>
    <dbReference type="SMR" id="Q32E73"/>
    <dbReference type="STRING" id="300267.SDY_2305"/>
    <dbReference type="EnsemblBacteria" id="ABB62382">
        <property type="protein sequence ID" value="ABB62382"/>
        <property type="gene ID" value="SDY_2305"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2305"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2782"/>
    <dbReference type="HOGENOM" id="CLU_046550_5_1_6"/>
    <dbReference type="OMA" id="HYGKGLP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001883">
        <property type="term" value="F:purine nucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008428">
        <property type="term" value="F:ribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060701">
        <property type="term" value="P:negative regulation of ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01205">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024900">
        <property type="entry name" value="O-Ac-ADP-ribose_deAcase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000409486" description="O-acetyl-ADP-ribose deacetylase">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="177" mass="18938" checksum="077C63DE7FA5ADBB" modified="2005-12-06" version="1">MKTRIHVVQGDITKLAVDVIVNVTNPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDCPTGHAVITLAGDLPAKAVVHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPAISTGVYGYPRAAAAEIAVKTVSEFITRHALPEQVYFVCYDEENAHLYERLLTQQGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EE0</accession>
    <name>Q32EE0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Exodeoxyribonuclease I</fullName>
            <ecNumber evidence="2 12">3.1.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">sbcB</name>
        <name evidence="18" type="ordered locus">SDY_2231</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 Mg(2+) ions per monomer.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.1" evidence="2 12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000980578.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403806.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EE0"/>
    <dbReference type="STRING" id="300267.SDY_2231"/>
    <dbReference type="EnsemblBacteria" id="ABB62315">
        <property type="protein sequence ID" value="ABB62315"/>
        <property type="gene ID" value="SDY_2231"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2231"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2696"/>
    <dbReference type="HOGENOM" id="CLU_043508_1_1_6"/>
    <dbReference type="OMA" id="RDRPAQF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008852">
        <property type="term" value="F:exodeoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023607">
        <property type="entry name" value="Exodeoxyribonuclease_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034748">
        <property type="entry name" value="EXOI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034747">
        <property type="entry name" value="EXOI_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038649">
        <property type="entry name" value="EXOI_SH3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013620">
        <property type="entry name" value="Exonuc_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08411">
        <property type="entry name" value="Exonuc_X-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000977">
        <property type="entry name" value="Exodeoxyribonuclease_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51785">
        <property type="entry name" value="EXOI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51784">
        <property type="entry name" value="EXOI_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ExoI SH3-like" evidence="16">
        <location>
            <begin position="202"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="ExoI C-terminal" evidence="17">
        <location>
            <begin position="358"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Important for interaction with ssb" evidence="15">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="15">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Important for interaction with ssb" evidence="15">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="site" description="Important for interaction with ssb" evidence="15">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="site" description="Important for interaction with ssb" evidence="15">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000977-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000977-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000977-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB62315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="475" mass="54503" checksum="963F90F88BB38AA8" modified="2005-12-06" version="1">MMNDGKQQSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNLIGEPEVFYCKPADDYLPQPGAVLITGITPQEARAKGENEAAFAARIHSLFTVPKTCILGYNNVRFDDEVTRNIFYRNFYDPYAWSWQHDNSRWDLLDVMRACYTLRPEGINWPENDDGLPSFRLEHLTKANGIEHSNAHDAMADVYATIAMAKLVKTRQPRLFDYLFTHRNKHKLMALIDVPQMNPLVHVSGMFGAWRGNTSWVAPLAWHPENRNAVIMVDLAGDISPLLELDSDTLRERLYTAKTDLGDNAAVPVKLVHINKCPVLAQANTLRPEDADRLGINRQHCLDNLKILRENPQVREKVVAIFAEAEPFTPSDNVDAQLYNGFFSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRARNFPGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLAQQYADDKEKVALLKALWQYAEEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EM7</accession>
    <name>Q32EM7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EM7"/>
    <dbReference type="STRING" id="300267.SDY_2140"/>
    <dbReference type="EnsemblBacteria" id="ABB62228">
        <property type="protein sequence ID" value="ABB62228"/>
        <property type="gene ID" value="SDY_2140"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2140"/>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_6"/>
    <dbReference type="OMA" id="ETKMGVR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="2">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="126"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="365" mass="39240" checksum="D854B51FB216D854" modified="2005-12-06" version="1">MPQQNYLDELTPAFTPLLAIKEASRCLLCHDAPCSQACPAQTDPGKFIRSIYFRNFKGAAETIRENNALGAVCARVCPTEKLCQSGCTRAGVDAPIDIGRLQRFVTDFEQQTGMEIYQPGTKTLGKVAIIGAGPAGLQASVTLTNQGYDVTIYEKEAHPGGRLRNGIPQFRLPQSVLDAEIARIEKMGVTIKCNNEVGKTLTLEQLKAENRAVLVTVGLSSGSGLPQFEHSDVEIAVDFLLRARQAQGDISIPQSALIIGGGDVAMDVASTLKVLGCQAVTCIAREELDEFPASEKEFASARELGVSIIDGFTPVAVEGNKVTFKHVRLSGELTMAADKIILAVGQHARLDAFAKLEPQRNTIKT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FB8</accession>
    <name>RNT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease T</fullName>
            <ecNumber evidence="1">3.1.13.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exoribonuclease T</fullName>
            <shortName evidence="1">RNase T</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnt</name>
        <name type="ordered locus">SDY_1878</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase T family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001282281.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403478.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FB8"/>
    <dbReference type="SMR" id="Q32FB8"/>
    <dbReference type="STRING" id="300267.SDY_1878"/>
    <dbReference type="EnsemblBacteria" id="ABB61987">
        <property type="protein sequence ID" value="ABB61987"/>
        <property type="gene ID" value="SDY_1878"/>
    </dbReference>
    <dbReference type="GeneID" id="67415644"/>
    <dbReference type="KEGG" id="sdy:SDY_1878"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2257"/>
    <dbReference type="HOGENOM" id="CLU_082724_0_0_6"/>
    <dbReference type="OMA" id="CYMVNHL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016896">
        <property type="term" value="F:exoribonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06134">
        <property type="entry name" value="RNaseT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00157">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005987">
        <property type="entry name" value="RNase_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30231:SF2">
        <property type="entry name" value="PTHR30231:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01298">
        <property type="entry name" value="RNaseT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000011422" description="Ribonuclease T">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate binding and specificity" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate binding and specificity" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate binding and specificity" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate binding and specificity" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00157"/>
        </source>
    </evidence>
    <sequence length="215" mass="23533" checksum="502C1CCEFABD9B05" modified="2005-12-06" version="1">MSDNAQLTGLCDRFRGFYPVVIDVETAGFNAKTDALLEIAAITLKMDEQGWLMPDTTLHFHVEPFVGANLQPEALAFNGIDPNDPDRGAVSEYEALHEIFKVVRKGIKASGCNRAIMVAHNANFDHSFMMAAAERASLKRNPFHPFATFDTAALAGLALGQTVLSKACQTAGMDFDSTQAHSALYDTERTAVLFCEIVNRWKRLGGWPLPAAEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FC5</accession>
    <name>Q32FC5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000250632.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403471.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FC5"/>
    <dbReference type="STRING" id="300267.SDY_1871"/>
    <dbReference type="EnsemblBacteria" id="ABB61980">
        <property type="protein sequence ID" value="ABB61980"/>
        <property type="gene ID" value="SDY_1871"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1871"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2250"/>
    <dbReference type="HOGENOM" id="CLU_023205_8_0_6"/>
    <dbReference type="OMA" id="VVYAWVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="18"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="298" mass="33704" checksum="02131238EA4C4D17" modified="2005-12-06" version="1">MVQRITIAPEGPEFSRFVMGYWRLMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALKLAPHLRERMEIVSKCGIATTAREENVIGHYITDRNHIIKSAEQSLINLATDHLDLLLIHRPDPLMDADEVADAFKHLHQSGKVRHFGVSNFTPAQFALLQSRLPFTLATNQVEISPVHQPLLLDGTLDQLQQLRVRPMAWSCLGGGRLFNDDYFQPLRDELAVVAEELNAGSIEQVVYAWVLRLPSQPLPIIGSGKIERVRAAVEAETLKMTRQQWFRIRRAALGYDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FL1</accession>
    <name>Q32FL1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000431831.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403385.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FL1"/>
    <dbReference type="STRING" id="300267.SDY_1779"/>
    <dbReference type="ESTHER" id="shifl-SF1808">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="MEROPS" id="S33.A54"/>
    <dbReference type="EnsemblBacteria" id="ABB61894">
        <property type="protein sequence ID" value="ABB61894"/>
        <property type="gene ID" value="SDY_1779"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1779"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2144"/>
    <dbReference type="HOGENOM" id="CLU_038914_0_0_6"/>
    <dbReference type="OMA" id="TWAHDYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022744">
        <property type="entry name" value="MeTrfase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12147">
        <property type="entry name" value="Methyltransf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="32"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_20" evidence="2">
        <location>
            <begin position="275"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="585" mass="65552" checksum="38E3D12190DCF097" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FR0</accession>
    <name>Q32FR0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000027563.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403336.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FR0"/>
    <dbReference type="STRING" id="300267.SDY_1725"/>
    <dbReference type="EnsemblBacteria" id="ABB61845">
        <property type="protein sequence ID" value="ABB61845"/>
        <property type="gene ID" value="SDY_1725"/>
    </dbReference>
    <dbReference type="GeneID" id="58460449"/>
    <dbReference type="KEGG" id="sdy:SDY_1725"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2080"/>
    <dbReference type="HOGENOM" id="CLU_013985_4_4_6"/>
    <dbReference type="OMA" id="IFAHNQP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="172" mass="19249" checksum="EDADBC63C0916807" modified="2005-12-06" version="1">MSIRFARKADCAAIAEIYNHAVLYTAAIWNDQTVDADNRIAWFEARTIAGYPVLVSEEDGVVTGYASFGDWRSFDGFRHTVEHSVYVHPDHQGKGLGRKLLSRLIDEARDCGKHVMVAGIESQNQASLHLHQSLGFVVTAQMPQVGTKFGRWLDLTFMQLQLDERTEPDAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FT8</accession>
    <name>Q32FT8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yoaG</name>
        <name evidence="1" type="ordered locus">SDY_1696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000513737.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403308.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FT8"/>
    <dbReference type="SMR" id="Q32FT8"/>
    <dbReference type="STRING" id="300267.SDY_1696"/>
    <dbReference type="EnsemblBacteria" id="ABB61817">
        <property type="protein sequence ID" value="ABB61817"/>
        <property type="gene ID" value="SDY_1696"/>
    </dbReference>
    <dbReference type="GeneID" id="60668262"/>
    <dbReference type="KEGG" id="sdy:SDY_1696"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2045"/>
    <dbReference type="HOGENOM" id="CLU_211215_0_0_6"/>
    <dbReference type="OMA" id="MAFYVPD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015051">
        <property type="entry name" value="YoaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036489">
        <property type="entry name" value="YoaG_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08956">
        <property type="entry name" value="DUF1869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103063">
        <property type="entry name" value="SSF103063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="60" mass="6608" checksum="39B37ADEDB319DB9" modified="2005-12-06" version="1">MGKATYTVTVTNNSNGVSVDYETETPMTLLVPEVAAEVIKDLVNTVRSYDTENEHDVCGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FZ8</accession>
    <name>Q32FZ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator LYSR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yneJ</name>
        <name evidence="3" type="ordered locus">SDY_1633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000366509.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403248.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FZ8"/>
    <dbReference type="STRING" id="300267.SDY_1633"/>
    <dbReference type="EnsemblBacteria" id="ABB61757">
        <property type="protein sequence ID" value="ABB61757"/>
        <property type="gene ID" value="SDY_1633"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1633"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1966"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_6"/>
    <dbReference type="OMA" id="AFERGCT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="293" mass="32429" checksum="EAAE57E7DBF7283C" modified="2005-12-06" version="1">MDLTQLEMFNAVAEAGSITQAAAKVHRVPSNLTTRLRQLETELGVDLFIRENQRLRLSPAGHNFLRYSQQILALVDEARSVVAGDEPQGLFSLGSLESTAAVRIPATLAEFNRRYPKIQFSLSTGPSGTMLEGVLEGKLNAAFIDGPVNHTAIDGIPVYREELMIVTPQGHAAVIRASQVNGSNIYAFRANCSYRRHFESWFHADGAAPGTIHEMESYHGMLACVVAGAGIALIPRSMLESMPGHHQVEAWPLAEQWRWLTTWLVWRRGAKTRPLEAFIQLLDVPDSARQGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G23</accession>
    <name>Q32G23_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Formate dehydrogenase iron-sulfur subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">fdnH</name>
        <name evidence="16" type="ordered locus">SDY_1605</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12 13">Binds 4 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001240591.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403223.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G23"/>
    <dbReference type="STRING" id="300267.SDY_1605"/>
    <dbReference type="EnsemblBacteria" id="ABB61732">
        <property type="protein sequence ID" value="ABB61732"/>
        <property type="gene ID" value="SDY_1605"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1605"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1929"/>
    <dbReference type="HOGENOM" id="CLU_043374_0_3_6"/>
    <dbReference type="OMA" id="FCVDRIQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:formate oxidation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Form-deh_trans"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
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        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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            <label>4</label>
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        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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            <label>4</label>
        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
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        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
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            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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            <label>2</label>
        </ligand>
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        <location>
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        </location>
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            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036298-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB61732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="294" mass="32157" checksum="454361F4AF09EF35" modified="2005-12-06" version="1">MAMETQDIIKRSATNSITPPSQVRDYKAEVAKLIDVSTCIGCKACQVACSEWNDIRDEVGHCVGVYDNPADLSAKSWTVMRFSETEQNGKLEWLIRKDGCMHCEDPGCLKACPSAGAIIQYANGIVDFQSENCIGCGYCIAGCPFNIPRLNKEDNRVYKCTLCVDRVSVGQEPACVKTCPTGAIHFGTKKEMLELAEQRVAKLKARGYEHAGVYNPEGVGGTHVMYVLHHADQSELYHGLPKDPKIDTSVSLWKGALKPLAAAGFIATFAGLIFHYIGIGPNKEVDDDEEDHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G36</accession>
    <name>Q32G36_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
            <ecNumber evidence="2">2.7.7.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ydeH</name>
        <name evidence="4" type="ordered locus">SDY_1590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24898"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="2.7.7.65"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000592774.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403210.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G36"/>
    <dbReference type="STRING" id="300267.SDY_1590"/>
    <dbReference type="EnsemblBacteria" id="ABB61719">
        <property type="protein sequence ID" value="ABB61719"/>
        <property type="gene ID" value="SDY_1590"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1590"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1909"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_5_6"/>
    <dbReference type="OMA" id="NIRSNMD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="157"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="296" mass="33908" checksum="89982B7B09722586" modified="2005-12-06" version="1">MIKKTMEIDVILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDHLGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDYKIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAISHSEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G69</accession>
    <name>Q32G69_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NAD(P) transhydrogenase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pntA</name>
        <name evidence="14" type="ordered locus">SDY_1550</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378711.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403177.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G69"/>
    <dbReference type="STRING" id="300267.SDY_1550"/>
    <dbReference type="EnsemblBacteria" id="ABB61686">
        <property type="protein sequence ID" value="ABB61686"/>
        <property type="gene ID" value="SDY_1550"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1550"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1859"/>
    <dbReference type="HOGENOM" id="CLU_003376_2_1_6"/>
    <dbReference type="OMA" id="YFPMLMT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008746">
        <property type="term" value="F:NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000203">
        <property type="entry name" value="NADP_transhydrogenase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_N" evidence="13">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="12">
        <location>
            <begin position="146"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB61686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="510" mass="54584" checksum="9936B82F615A776F" modified="2005-12-06" version="1">MRIGIPRERLTNETRVAATPKTVEQLLKLGFTVAVESGAGQLASFDDKAFVQAGAEIVEGNSVWQSEIILKVNAPLDDEIALLNPGTTLVSFIWPAQNPELMQKLAERNVTVMAMDSVPRISRAQSLDALSSMANIAGYRAIVEAAHEFGRFFTGQITAAGKVPPAKVMVIGAGVAGLAAIGAANSLGAIVRAFDTRPEVKEQVQSMGAEFLELDFKEEAGSGDGYAKVMSDAFIKAEMELFAAQAKEVDIIVTTALIPGKPAPKLITREMVDSMKAGSVIVDLAAQNGGNCEYTVPGEIFTTENGVKVIGYTDLPGRLPTQSSQLYGTNLVNLLKLLCKEKDGNITVDFDDVVIRGVTVIRAGEITWPAPPIHVSAQPQAAQKAAPEVKTEEKCACSPWRKYALMALAIILFGWLASVAPKEFLGHFTVFALACVVGYYVVWNVSHALHTPLMSVTNAISGIIVVGALLQIGQGGWVSFLSFIAVLIASINIFGGFTVTQRMLKMFRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GB8</accession>
    <name>Q32GB8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DEOR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000719095.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403128.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GB8"/>
    <dbReference type="STRING" id="300267.SDY_1498"/>
    <dbReference type="EnsemblBacteria" id="ABB61637">
        <property type="protein sequence ID" value="ABB61637"/>
        <property type="gene ID" value="SDY_1498"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1498"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1787"/>
    <dbReference type="HOGENOM" id="CLU_060699_1_4_6"/>
    <dbReference type="OMA" id="IMAMLNE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="252" mass="28266" checksum="7D9893661715F911" modified="2005-12-06" version="1">MAAKDRIQAIKQMVANDKKVTVSNLSGIFQVTEETIRRDLEKLEDEGFLTRTYGGAVLNTAMLTENIHFYKRASSFYEEKQLIARKALPFIDNKTTMAADSSSTVMELLKLLQDRSDLTLLTNSAEAIHVLAQSEIKVVSTGGELNKNTLSLQGRITKEIISRYHVDIMVMSCKGLDINSGALDSNEAEAETKKTMIRQATEVVLLVDHSKFDRKAFVQLADFSHINYIITDKSPGAEWIAFCKDNNIQLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GC5</accession>
    <name>Q32GC5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000645219.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403121.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GC5"/>
    <dbReference type="STRING" id="300267.SDY_1491"/>
    <dbReference type="EnsemblBacteria" id="ABB61630">
        <property type="protein sequence ID" value="ABB61630"/>
        <property type="gene ID" value="SDY_1491"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1491"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1779"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_6"/>
    <dbReference type="OMA" id="RSAACKV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="185"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="358" mass="38702" checksum="B286269F170ED24D" modified="2005-12-06" version="1">MKALARFGKAFGGYKMIDVPQPMCGPEDVVIEIKAAAICGADMKHYNVDSGSDEFNSIRGHEFAGCIAQVGEKVKDWKVGQRVVSDNSGHVCGVCPACEQGDFLCCTEKVNLGLDNNAWGGGFSKYCLVPGEILKIHRHALWEIPDGVDYEDAAVLDPICNAYKSIAQQSKFLPGQDVVVIGTGPLGLFSVQMARIMGAVNIVVVGLQEDVAVRFPVAKELGATAVVNGSTEDVVARCQQICGKDNLGLVIECSGANIALKQAIEMLRPNGEVVRVGMGFKPLDFSINDITAWNKSIIGHMAYDSTSWRNAIRLLASGAIKVKPMITHRIGLSQWREGFDAMVDKTAIKVIMTYDFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GG4</accession>
    <name>Q32GG4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GG4"/>
    <dbReference type="EnsemblBacteria" id="ABB61591">
        <property type="protein sequence ID" value="ABB61591"/>
        <property type="gene ID" value="SDY_1450"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1450"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32043" checksum="D1E38F16FDA7C804" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAGTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKRIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GL7</accession>
    <name>Q32GL7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysis protein S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000284488.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403029.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GL7"/>
    <dbReference type="EnsemblBacteria" id="ABB61538">
        <property type="protein sequence ID" value="ABB61538"/>
        <property type="gene ID" value="SDY_1393"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1393"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1654"/>
    <dbReference type="HOGENOM" id="CLU_180637_0_0_6"/>
    <dbReference type="OMA" id="GFSSEQW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007054">
        <property type="entry name" value="Lysis_S"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04971">
        <property type="entry name" value="Phage_holin_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030786">
        <property type="entry name" value="Lysis_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8118" checksum="DBEC9C39F2DAA348" modified="2005-12-06" version="1">MYQMEKITTGVSYTTSAVGMGYWFLQFLDRVSPSQWAAIGVLGSLLFGLLTYLTNLYFKIREDRRKAARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GU5</accession>
    <name>Q32GU5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402951.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GU5"/>
    <dbReference type="STRING" id="300267.SDY_1313"/>
    <dbReference type="EnsemblBacteria" id="ABB61460">
        <property type="protein sequence ID" value="ABB61460"/>
        <property type="gene ID" value="SDY_1313"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1313"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1560"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_9_6"/>
    <dbReference type="OMA" id="MRWHTKF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11510" checksum="7EB16CCBBF0ACBCA" modified="2005-12-06" version="1">MKKRNFSAEFKRESAQLVVDQNYTVADAAKAMDVGLSTMTRWVKQLRDERQGKTPKASPITPEQIEIRELRKKLQRIEMENEILKKASALLMSDSLNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GY5</accession>
    <name>Q32GY5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ychN</name>
        <name evidence="1" type="ordered locus">SDY_1271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001169669.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402911.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GY5"/>
    <dbReference type="SMR" id="Q32GY5"/>
    <dbReference type="STRING" id="300267.SDY_1271"/>
    <dbReference type="EnsemblBacteria" id="ABB61420">
        <property type="protein sequence ID" value="ABB61420"/>
        <property type="gene ID" value="SDY_1271"/>
    </dbReference>
    <dbReference type="GeneID" id="66674958"/>
    <dbReference type="KEGG" id="sdy:SDY_1271"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1508"/>
    <dbReference type="HOGENOM" id="CLU_151801_2_0_6"/>
    <dbReference type="OMA" id="VKACGPC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="117" mass="12693" checksum="49D1E3550CFDEFAC" modified="2005-12-06" version="1">MQKIVIVANGAPYGSESLFNSLRLAIALREQESNLDLRLFLMSDAVTAGLRGQKPGEGYNIQQMLEILTAQNVPVKLCKTCTDGRGISTLPLIDGVEIGTLVELAQWTLSADKVLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H72</accession>
    <name>Q32H72_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H72"/>
    <dbReference type="EnsemblBacteria" id="ABB61333">
        <property type="protein sequence ID" value="ABB61333"/>
        <property type="gene ID" value="SDY_1177"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1177"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7451" checksum="BA8C80957B6DDF11" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITRFLYCSGIKKGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HB1</accession>
    <name>Q32HB1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphogluconate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">edd</name>
        <name evidence="7" type="ordered locus">SDY_1137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="4.2.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; Entner-Doudoroff pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.12" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001069439.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402785.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HB1"/>
    <dbReference type="STRING" id="300267.SDY_1137"/>
    <dbReference type="EnsemblBacteria" id="ABB61294">
        <property type="protein sequence ID" value="ABB61294"/>
        <property type="gene ID" value="SDY_1137"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1137"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1339"/>
    <dbReference type="HOGENOM" id="CLU_014271_1_2_6"/>
    <dbReference type="OMA" id="CANIAHV"/>
    <dbReference type="UniPathway" id="UPA00226"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004456">
        <property type="term" value="F:phosphogluconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046177">
        <property type="term" value="P:D-gluconate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009255">
        <property type="term" value="P:Entner-Doudoroff pathway through 6-phosphogluconate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02094">
        <property type="entry name" value="Edd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004786">
        <property type="entry name" value="6-phosphgluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43661:SF1">
        <property type="entry name" value="PTHR43661:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01196">
        <property type="entry name" value="edd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="603" mass="64629" checksum="DCF9ED5D243DB64A" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HH2</accession>
    <name>Q32HH2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_0535</name>
        <name evidence="5" type="ordered locus">SDY_1068</name>
        <name evidence="6" type="ordered locus">SDY_1186</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402230.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402724.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402832.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0535"/>
    <dbReference type="EnsemblBacteria" id="ABB60741">
        <property type="protein sequence ID" value="ABB60741"/>
        <property type="gene ID" value="SDY_0535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61233">
        <property type="protein sequence ID" value="ABB61233"/>
        <property type="gene ID" value="SDY_1068"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61341">
        <property type="protein sequence ID" value="ABB61341"/>
        <property type="gene ID" value="SDY_1186"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0535"/>
    <dbReference type="KEGG" id="sdy:SDY_1068"/>
    <dbReference type="KEGG" id="sdy:SDY_1186"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1256"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="OMA" id="DYKLESA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11189" checksum="D447183B2EF4D61E" modified="2005-12-06" version="1">MSRKNQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGPLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKATAYFAQESLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HN2</accession>
    <name>Q32HN2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000976859.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402664.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HN2"/>
    <dbReference type="STRING" id="300267.SDY_1008"/>
    <dbReference type="EnsemblBacteria" id="ABB61173">
        <property type="protein sequence ID" value="ABB61173"/>
        <property type="gene ID" value="SDY_1008"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1008"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1176"/>
    <dbReference type="HOGENOM" id="CLU_114884_0_0_6"/>
    <dbReference type="OMA" id="KDSAWLY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046025">
        <property type="entry name" value="DUF5983"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19419">
        <property type="entry name" value="DUF5983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="163" mass="18063" checksum="00D0CE187CFAAA62" modified="2005-12-06" version="1">MMKLALTLEADSVNVQALNMGRIVVDVDGIELAELINVVCDNGHSLRVVDESDRASTDCTPPFAALTGIRCSTAHITAKDNAWLYSLSHQTNDTGESEWIHFTGSGYLLRTDAWSYPVLRLKRLGLSKTFRRLVVTLIRRYGVSLIHLDASAECLPGLPTFDW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-11-16" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HW0</accession>
    <name>ZAPC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein ZapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">zapC</name>
        <name type="ordered locus">SDY_0919</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts directly with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZapC family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB61095" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61095.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020285.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402586.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HW0"/>
    <dbReference type="SMR" id="Q32HW0"/>
    <dbReference type="STRING" id="300267.SDY_0919"/>
    <dbReference type="EnsemblBacteria" id="ABB61095">
        <property type="protein sequence ID" value="ABB61095"/>
        <property type="gene ID" value="SDY_0919"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0919"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1065"/>
    <dbReference type="HOGENOM" id="CLU_128248_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00906">
        <property type="entry name" value="ZapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009809">
        <property type="entry name" value="ZapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07126">
        <property type="entry name" value="ZapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010252">
        <property type="entry name" value="ZapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000413790" description="Cell division protein ZapC">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="180" mass="20582" checksum="0594F43385D4CEA7" modified="2011-11-16" version="2">MRIKPDDNWRWYYDKEHDRMMLDLADGMLFRSRFARKMLTPDAFSPAGFCVDDASLYFSFEEKCRDFNLSKEQKAELVLNALVAIRYLKPQMPKSWHFVSHGEMWVPMPGDAACVWLSDTNEQVNLLVVESGENAALCLLAQPCVVIAGRAMQLGDAIKIMNDRLKPQVNVDSFSLEQAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HY5</accession>
    <name>RL25_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplY</name>
        <name type="ordered locus">SDY_0894</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000494183.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402561.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HY5"/>
    <dbReference type="SMR" id="Q32HY5"/>
    <dbReference type="STRING" id="300267.SDY_0894"/>
    <dbReference type="EnsemblBacteria" id="ABB61070">
        <property type="protein sequence ID" value="ABB61070"/>
        <property type="gene ID" value="SDY_0894"/>
    </dbReference>
    <dbReference type="GeneID" id="67414531"/>
    <dbReference type="KEGG" id="sdy:SDY_0894"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1035"/>
    <dbReference type="HOGENOM" id="CLU_137946_0_0_6"/>
    <dbReference type="OMA" id="HAGKFPA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01336">
        <property type="entry name" value="Ribosomal_L25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020055">
        <property type="entry name" value="Ribosomal_L25_short"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000243107" description="50S ribosomal protein L25">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01336"/>
        </source>
    </evidence>
    <sequence length="94" mass="10693" checksum="85DAF5ACBA1C5F86" modified="2005-12-06" version="1">MFTINAEVRKEQGKGASRRLRAANKFPAIIYGGKEAPLAIELDHDKVMNMQAKAEFYSEVLTIVVDGKEIKVKAQDVQRHPYKPKLQHIDFVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I63</accession>
    <name>Q32I63_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybhQ</name>
        <name evidence="2" type="ordered locus">SDY_0812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000871981.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402483.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I63"/>
    <dbReference type="STRING" id="300267.SDY_0812"/>
    <dbReference type="EnsemblBacteria" id="ABB60994">
        <property type="protein sequence ID" value="ABB60994"/>
        <property type="gene ID" value="SDY_0812"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0812"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.936"/>
    <dbReference type="HOGENOM" id="CLU_147415_0_0_6"/>
    <dbReference type="OMA" id="HDFASKH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021303">
        <property type="entry name" value="Uncharacterised_YbhQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11076">
        <property type="entry name" value="YbhQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="136" mass="15435" checksum="DF497B0FD664AB4A" modified="2005-12-06" version="1">MKWQQRVRVATGLSCWQIMLHLLVVALLVVGWMSKTLVHVGVGLCALYCVTVVMMLVFQRHPEQRWREVADVLEELTTTWYFGAALIVLWLLSRVLENNFLLAIAGLAILAGPAVVSLLAKDKKLHHLASKHRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I81</accession>
    <name>Q32I81_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative outer membrane receptor for iron transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_0794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402465.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I81"/>
    <dbReference type="STRING" id="300267.SDY_0794"/>
    <dbReference type="EnsemblBacteria" id="ABB60976">
        <property type="protein sequence ID" value="ABB60976"/>
        <property type="gene ID" value="SDY_0794"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0794"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.917"/>
    <dbReference type="HOGENOM" id="CLU_008287_9_1_6"/>
    <dbReference type="OMA" id="TWGSDQT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015891">
        <property type="term" value="P:siderophore transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB_dep_Rec" evidence="3">
        <location>
            <begin position="111"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="609" mass="66057" checksum="A14C7CDC590FCDAB" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IB9</accession>
    <name>Q32IB9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_0754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402427.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IB9"/>
    <dbReference type="STRING" id="300267.SDY_0754"/>
    <dbReference type="EnsemblBacteria" id="ABB60938">
        <property type="protein sequence ID" value="ABB60938"/>
        <property type="gene ID" value="SDY_0754"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0754"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.868"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="OMA" id="IIDMAMD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="9899" checksum="E889588966B3BF7E" modified="2005-12-06" version="1">MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMDGVGCRATARIMGVSLNTILRHLKNSGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IC1</accession>
    <name>Q32IC1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402425.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IC1"/>
    <dbReference type="STRING" id="300267.SDY_0752"/>
    <dbReference type="EnsemblBacteria" id="ABB60936">
        <property type="protein sequence ID" value="ABB60936"/>
        <property type="gene ID" value="SDY_0752"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0752"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.866"/>
    <dbReference type="HOGENOM" id="CLU_044146_6_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9756" checksum="DE88A8F37D0A11A2" modified="2005-12-06" version="1">MSIKLIAVGMDGTFLSDQKTYNRERFMAQYQQMKAQGIRFVVASGNQYYQLISFFPEIANEIAFVAENGGWVVSEGKDVLVMTLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IC3</accession>
    <name>Q32IC3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DEOR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020071.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402423.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IC3"/>
    <dbReference type="STRING" id="300267.SDY_0750"/>
    <dbReference type="EnsemblBacteria" id="ABB60934">
        <property type="protein sequence ID" value="ABB60934"/>
        <property type="gene ID" value="SDY_0750"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0750"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.864"/>
    <dbReference type="HOGENOM" id="CLU_069356_21_2_6"/>
    <dbReference type="OMA" id="SMTYHFD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="178" mass="20337" checksum="B7F1C3F1C38EEF7B" modified="2005-12-06" version="1">MRRANDPQRREKIIQATLEAVKLYGIHAVTHRKIATLAGVPLGSMTYYFSGIDELLLEAFSSFTEIMSRQYQAFFSDVSDAQGACQAITDMIYSSQVATPDNMELMYQLYALASRKPLLKTVMQNWMQRSQQTLEQWFEPGTARALDAFIEGMTLHFVTDRKPLSREEILRMVKRVAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IC5</accession>
    <name>YBJL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative transport protein YbjL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybjL</name>
        <name type="ordered locus">SDY_0748</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001024869.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402421.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IC5"/>
    <dbReference type="STRING" id="300267.SDY_0748"/>
    <dbReference type="EnsemblBacteria" id="ABB60932">
        <property type="protein sequence ID" value="ABB60932"/>
        <property type="gene ID" value="SDY_0748"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0748"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.862"/>
    <dbReference type="HOGENOM" id="CLU_035023_2_2_6"/>
    <dbReference type="OMA" id="RDGKNYF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01015">
        <property type="entry name" value="YbjL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023017">
        <property type="entry name" value="Transp_YbjL_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006512">
        <property type="entry name" value="YidE_YbjL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06826">
        <property type="entry name" value="Asp-Al_Ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01625">
        <property type="entry name" value="YidE_YbjL_dupl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000226888" description="Putative transport protein YbjL">
        <location>
            <begin position="1"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal 1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal 2" evidence="1">
        <location>
            <begin position="292"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01015"/>
        </source>
    </evidence>
    <sequence length="561" mass="60215" checksum="CFD6F8CD7C8F323F" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IQ1</accession>
    <name>Q32IQ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system, N-acetylglucosamine-specific enzyme IIABC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">nagE</name>
        <name evidence="16" type="ordered locus">SDY_0613</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_001023088.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
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    <dbReference type="RefSeq" id="YP_402295.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
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    <dbReference type="AlphaFoldDB" id="Q32IQ1"/>
    <dbReference type="STRING" id="300267.SDY_0613"/>
    <dbReference type="EnsemblBacteria" id="ABB60806">
        <property type="protein sequence ID" value="ABB60806"/>
        <property type="gene ID" value="SDY_0613"/>
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    <dbReference type="KEGG" id="sdy:SDY_0613"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.709"/>
    <dbReference type="HOGENOM" id="CLU_012312_1_3_6"/>
    <dbReference type="OMA" id="IVHCARP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0019866">
        <property type="term" value="C:organelle inner membrane"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
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    <dbReference type="GO" id="GO:0015572">
        <property type="term" value="F:N-acetylglucosamine transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
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        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:phosphorylation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Dup_hybrid_motif"/>
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        <property type="entry name" value="Glu_permease_IIB"/>
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        <property type="entry name" value="PTrfase_EIIB_Cys"/>
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        <property type="entry name" value="PTS_EIIA_1_perm"/>
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        <property type="entry name" value="PTS_EIIC"/>
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        <property type="entry name" value="PTS_EIIC_1"/>
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        <property type="entry name" value="PTS_IIB_1"/>
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        <property type="entry name" value="PTS_IIBC_nag"/>
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        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PTS_EIIC"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
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    <dbReference type="TIGRFAMs" id="TIGR01998">
        <property type="entry name" value="PTS-II-BC-nag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="185"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="252"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="276"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="390"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="517"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB60806.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="648" mass="68314" checksum="CDC76F7B6C67C250" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IR1</accession>
    <name>MIAB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="1">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaB</name>
        <name type="ordered locus">SDY_0597</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000162740.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402285.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IR1"/>
    <dbReference type="SMR" id="Q32IR1"/>
    <dbReference type="STRING" id="300267.SDY_0597"/>
    <dbReference type="EnsemblBacteria" id="ABB60796">
        <property type="protein sequence ID" value="ABB60796"/>
        <property type="gene ID" value="SDY_0597"/>
    </dbReference>
    <dbReference type="GeneID" id="66671065"/>
    <dbReference type="KEGG" id="sdy:SDY_0597"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.701"/>
    <dbReference type="HOGENOM" id="CLU_018697_2_0_6"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000374552" description="tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase">
        <location>
            <begin position="1"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="143"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="378"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="474" mass="53663" checksum="49CBCB93888F7F9D" modified="2005-12-06" version="1">MTKKLHIKTWGCQMNEYDSSKMADLLDATHGYQLTDVAEEADVLLLNTCSIREKAQEKVFHQLGRWKLLKEKNPDLIIGVGGCVASQEGEHIRQRAHYVDIIFGPQTLHRLPEMINSVRGDRSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTYCVVPYTRGEEVSRPSDDILFEIAQLAAQGVREVNLLGQNVNAWRGENYDGTTGSFADLLRLVAAIDGIDRIRFTTSHPIEFTDDIIEVYRDTPELVSFLHLPVQSGSDRILNLMGRTHTALEYKAIIRKLRAARPDIQISSDFIVGFPGETTEDFEKTMKLIADVNFDMSYSFIFSARPGTPAADMVDDVPEEEKKQRLYILQERINQQAMAWSRRMLGTTQRILVEGTSRKSIMELSGRTENNRVVNFEGTPDMIGKFVDVEITDVYPNSLRGKVVRTEDEMGLRVAETPESVIARTRKENDLGVGYYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J91</accession>
    <name>Q32J91_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioesterase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tesA</name>
        <name evidence="2" type="ordered locus">SDY_0404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402105.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J91"/>
    <dbReference type="SMR" id="Q32J91"/>
    <dbReference type="STRING" id="300267.SDY_0404"/>
    <dbReference type="EnsemblBacteria" id="ABB60615">
        <property type="protein sequence ID" value="ABB60615"/>
        <property type="gene ID" value="SDY_0404"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0404"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.482"/>
    <dbReference type="HOGENOM" id="CLU_051180_3_0_6"/>
    <dbReference type="OMA" id="MRIPPNY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008265">
        <property type="entry name" value="Lipase_GDSL_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01098">
        <property type="entry name" value="LIPASE_GDSL_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="33"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="208" mass="23696" checksum="22DC6CA074614747" modified="2005-12-06" version="1">MMNFNNVFRWHLPFLFLVLLTFRAAAADTLLILGDSLSAGYRMSASAAWPALLNDKWQSKTSVVNASISSDTSQQGLARLPALLKQHQPRWVLVELGGNDGLRGFQPQQTEQTLRQILQDVKADNAEPLLMQIRLPANYGRRYNEAFSAIYPKLAKEFDVPLLPFFMEEVYLKPQWMQDDGIHPNRDAQPFIADWMAKQLQPLVNHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JG5</accession>
    <name>Q32JG5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside-specific channel-forming protein Tsx</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tsx</name>
        <name evidence="9" type="ordered locus">SDY_0323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295328.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402031.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JG5"/>
    <dbReference type="SMR" id="Q32JG5"/>
    <dbReference type="STRING" id="300267.SDY_0323"/>
    <dbReference type="EnsemblBacteria" id="ABB60542">
        <property type="protein sequence ID" value="ABB60542"/>
        <property type="gene ID" value="SDY_0323"/>
    </dbReference>
    <dbReference type="GeneID" id="67416514"/>
    <dbReference type="KEGG" id="sdy:SDY_0323"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.372"/>
    <dbReference type="HOGENOM" id="CLU_073836_0_0_6"/>
    <dbReference type="OMA" id="KSTGWGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003055">
        <property type="entry name" value="Channel_Tsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018013">
        <property type="entry name" value="Channel_Tsx-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036777">
        <property type="entry name" value="Channel_Tsx-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03502">
        <property type="entry name" value="Channel_Tsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01277">
        <property type="entry name" value="CHANNELTSX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111364">
        <property type="entry name" value="SSF111364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221139" description="Nucleoside-specific channel-forming protein Tsx" evidence="8">
        <location>
            <begin position="23"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="294" mass="33589" checksum="AB801DC563552A5C" modified="2005-12-06" version="1">MKKTLLAAGAVLALSSSFTVNAAENDKPQYLSDWWHQSVNVVGSYHTRFGPQIRNDTYLEYEAFAKKDWFDFYGYADAPVFFGGNSDAKGIWNHGSPLFMEIEPRFSIDKLTNTDLSFGPFKEWYFANNYIYDMGRNKDGRQSTWYMGLGTDIDTGLPMSLSMNVYAKYQWQNYGAANENEWDGYRFKIKYFVPITDLWGGQLSYIGFTNFDWGSDLGDDSGNAINGIKTRTNNSIASSHILALNYDHWHYSVVARYWHDGGQWNDDAELNFGNGNFNVRSTGWGGYLVVGYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JJ0</accession>
    <name>Q32JJ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible regulator of murein genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bolA</name>
        <name evidence="4" type="ordered locus">SDY_0298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JJ0"/>
    <dbReference type="STRING" id="300267.SDY_0298"/>
    <dbReference type="EnsemblBacteria" id="ABB60517">
        <property type="protein sequence ID" value="ABB60517"/>
        <property type="gene ID" value="SDY_0298"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0298"/>
    <dbReference type="HOGENOM" id="CLU_109462_3_1_6"/>
    <dbReference type="OMA" id="CLGGFGK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="SSF82657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="116" mass="13479" checksum="6240DCF4B66500B9" modified="2005-12-06" version="1">MTSQRCRRRYFMMIRERIEEKLRAAFQPVFLEVVDESYRHNVPAGSESHFKVVLVSDRFTGERFLNRHRMIYSTLAEELSTTVHALALHTYTIKEWEGLQDTVFASPPCRGAGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JK1</accession>
    <name>Q32JK1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybaW</name>
        <name evidence="2" type="ordered locus">SDY_0287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001194525.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401995.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JK1"/>
    <dbReference type="STRING" id="300267.SDY_0287"/>
    <dbReference type="EnsemblBacteria" id="ABB60506">
        <property type="protein sequence ID" value="ABB60506"/>
        <property type="gene ID" value="SDY_0287"/>
    </dbReference>
    <dbReference type="GeneID" id="58463326"/>
    <dbReference type="KEGG" id="sdy:SDY_0287"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.332"/>
    <dbReference type="HOGENOM" id="CLU_101141_4_2_6"/>
    <dbReference type="OMA" id="HIDLFQH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="132" mass="15097" checksum="3F834B185132FA9B" modified="2005-12-06" version="1">MQTQIKVRGYHLDVYQHVNNARYLEFLEEARWDGLENSDSFHWMTAHNIAFVVVNININYRRPAVLSDLLTITSQLQQLNGKSGILSQVITLEPEGQVVADALITFVCIDLKTQKALALEGELREKLEQMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JT5</accession>
    <name>Q32JT5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)</fullName>
            <ecNumber evidence="5">2.5.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ditrans,polycis-undecaprenylcistransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="5">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="5">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yaeS</name>
        <name evidence="5" type="synonym">uppS</name>
        <name evidence="6" type="ordered locus">SDY_0190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.31" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401911.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JT5"/>
    <dbReference type="SMR" id="Q32JT5"/>
    <dbReference type="STRING" id="300267.SDY_0190"/>
    <dbReference type="EnsemblBacteria" id="ABB60422">
        <property type="protein sequence ID" value="ABB60422"/>
        <property type="gene ID" value="SDY_0190"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0190"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.220"/>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_6"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008834">
        <property type="term" value="F:di-trans,poly-cis-decaprenylcistransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="4 5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="27"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="253" mass="28444" checksum="73DC9534C14CA7B9" modified="2005-12-06" version="1">MMLSATQPLSEKLPAHGCRHVAIIMDGNGRWAKKQGKIRAFGHKAGAKSVRRAVSFAANNGIEALTLYAFSSENWNRPAQEVSALMELFVWALDSEVKSLHRHNVRLRIIGDTSRFNSRLQERIRKSEALTAGNTGLTLNIAANYGGRWDIVQGVRQLAEKVQQGNLQPDQIDEEMLNQHVCMHELAPVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDEQDFEGALNAFANRERRFGGTEPGDETA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JT7</accession>
    <name>RRF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-recycling factor</fullName>
            <shortName evidence="1">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frr</name>
        <name type="ordered locus">SDY_0188</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000622418.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401909.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JT7"/>
    <dbReference type="SMR" id="Q32JT7"/>
    <dbReference type="STRING" id="300267.SDY_0188"/>
    <dbReference type="EnsemblBacteria" id="ABB60420">
        <property type="protein sequence ID" value="ABB60420"/>
        <property type="gene ID" value="SDY_0188"/>
    </dbReference>
    <dbReference type="GeneID" id="67416248"/>
    <dbReference type="KEGG" id="sdy:SDY_0188"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.218"/>
    <dbReference type="HOGENOM" id="CLU_073981_2_1_6"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000003267" description="Ribosome-recycling factor">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <sequence length="185" mass="20639" checksum="CBFB9675AAD0CFD8" modified="2005-12-06" version="1">MISDIRKDAEVRMDKCVEAFKTQISKIRTGRASPSLLDGIVVEYYGTPTPLRQLASVTVEDSRTLKINVFDRSMSPAVEKAIMASDLGLNPNSAGSDIRVPLPPLTEERRKDLTKIVRGEAEQARVAVRNVRRDANDKVKALLKDKEISEDDDRRSQDDVQKLTDAAIKKIEAALADKEAELMQF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JZ6</accession>
    <name>LPXC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
            <shortName evidence="1">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
            <ecNumber evidence="1">3.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxC</name>
        <name type="ordered locus">SDY_0126</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LpxC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.108" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000595482.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401850.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JZ6"/>
    <dbReference type="SMR" id="Q32JZ6"/>
    <dbReference type="STRING" id="300267.SDY_0126"/>
    <dbReference type="EnsemblBacteria" id="ABB60361">
        <property type="protein sequence ID" value="ABB60361"/>
        <property type="gene ID" value="SDY_0126"/>
    </dbReference>
    <dbReference type="GeneID" id="67416169"/>
    <dbReference type="KEGG" id="sdy:SDY_0126"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.145"/>
    <dbReference type="HOGENOM" id="CLU_046528_1_0_6"/>
    <dbReference type="OMA" id="IVFYRSD"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000253695" description="UDP-3-O-acyl-N-acetylglucosamine deacetylase">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <sequence length="305" mass="33956" checksum="CA439A00813463AB" modified="2005-12-06" version="1">MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K06</accession>
    <name>Q32K06_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">murF</name>
        <name evidence="11" type="ordered locus">SDY_0116</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000626691.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401840.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K06"/>
    <dbReference type="STRING" id="300267.SDY_0116"/>
    <dbReference type="EnsemblBacteria" id="ABB60351">
        <property type="protein sequence ID" value="ABB60351"/>
        <property type="gene ID" value="SDY_0116"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0116"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.135"/>
    <dbReference type="HOGENOM" id="CLU_031507_4_0_6"/>
    <dbReference type="OMA" id="VEMGANH"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="106"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="313"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="107"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="452" mass="47349" checksum="629D966EA531C7FA" modified="2005-12-06" version="1">MISVTLSQLTDILNGELQGADITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLDIDLPQLIVKDTRLAFGELAAWVRQQVPARVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTPEYDYAVIELGANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVWRFSPNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRLFPIQLAENQLLLDDSYNANVGSMTAAVQVLAEMPGYRVLVVGDMAELGAESEACHVQVGGAAKAAGIDRVLSVGKQSHAISTASGVGEHFADKTALITRLKSLIAEQQVITILVKGSRSAAMEEVVRALQENGTC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K31</accession>
    <name>ARAA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-arabinose isomerase</fullName>
            <ecNumber evidence="1">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">araA</name>
        <name type="ordered locus">SDY_0089</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arabinose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000151756.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401815.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K31"/>
    <dbReference type="SMR" id="Q32K31"/>
    <dbReference type="STRING" id="300267.SDY_0089"/>
    <dbReference type="EnsemblBacteria" id="ABB60326">
        <property type="protein sequence ID" value="ABB60326"/>
        <property type="gene ID" value="SDY_0089"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0089"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.104"/>
    <dbReference type="HOGENOM" id="CLU_045663_0_0_6"/>
    <dbReference type="OMA" id="HMLEICP"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0054">Arabinose catabolism</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000259344" description="L-arabinose isomerase">
        <location>
            <begin position="1"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <sequence length="500" mass="56105" checksum="18077C85A9335FDA" modified="2005-12-06" version="1">MTIFDNYEVWFVIGSQHLYGPETLRQVTQHAEHVVNALNTEAKLPCKLVLKPLGTTPDEITAICRDANYDDRCAGLVVWLHTFSPAKMWINGLTMLNKPLLQFHTQFNAALPWDSIDMDFMNLNQTAHGGREFSFIGARMRQQHAVVTGHWQDKQAHERIGSWMRQAVSKQDTRHLKVCRFGDNMREVAVTDGDKVAAQIKFGFSVNTWAVGDLVQVVNSISDGDVNALVDEYESCYTMTPATQIHGEKRQNVLEAARIELGMKRFLEQGGFHAFTTTFEDLHGLKQLPGLAVQRLMQQGYGFAGEGDWKTAALLRIMKVMSTGLQGGTSFMEDYTYHFEKGNDLVLGSHMLEVCPSIAAEEKPILDVQHLGIGGKDDPARLIFNTQTGPAIVASLIDLGDRYRLLVNCIDTVKTPHSLPKLPVANALWKAQPDLPTASEAWILAGGAHHTVFSHALNLNDMRQFAEMHDIEITVIDNDTRLPAFKDALRWNEVYYGFRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K44</accession>
    <name>APAG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein ApaG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">apaG</name>
        <name type="ordered locus">SDY_0075</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000610901.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401802.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K44"/>
    <dbReference type="SMR" id="Q32K44"/>
    <dbReference type="STRING" id="300267.SDY_0075"/>
    <dbReference type="EnsemblBacteria" id="ABB60313">
        <property type="protein sequence ID" value="ABB60313"/>
        <property type="gene ID" value="SDY_0075"/>
    </dbReference>
    <dbReference type="GeneID" id="66671660"/>
    <dbReference type="KEGG" id="sdy:SDY_0075"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.85"/>
    <dbReference type="HOGENOM" id="CLU_128074_0_0_6"/>
    <dbReference type="OMA" id="YVSGCNL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00791">
        <property type="entry name" value="ApaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023065">
        <property type="entry name" value="Uncharacterised_ApaG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="SSF110069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000083660" description="Protein ApaG">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="ApaG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00791"/>
        </source>
    </evidence>
    <sequence length="125" mass="13867" checksum="1D31BE408E748120" modified="2005-12-06" version="1">MINSPRVCIQVQSVYIEAQSSPDNERYVFAYTVTIRNLGRAPVQLLGRYWLITNGNGRETEVQGEGVVGVQPLIAPGEEYQYTSGAIIETPLGTMQGHYEMIDENGVPFSIDIPVFRLAVPTLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K49</accession>
    <name>Q32K49_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">K+ efflux antiporter, glutathione-regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">kefC</name>
        <name evidence="13" type="ordered locus">SDY_0070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
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    <dbReference type="AlphaFoldDB" id="Q32K49"/>
    <dbReference type="STRING" id="300267.SDY_0070"/>
    <dbReference type="EnsemblBacteria" id="ABB60308">
        <property type="protein sequence ID" value="ABB60308"/>
        <property type="gene ID" value="SDY_0070"/>
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    <dbReference type="KEGG" id="sdy:SDY_0070"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.80"/>
    <dbReference type="HOGENOM" id="CLU_005126_9_3_6"/>
    <dbReference type="OMA" id="PYLWFAK"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015503">
        <property type="term" value="F:glutathione-regulated potassium exporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051595">
        <property type="term" value="P:response to methylglyoxal"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="K_H_efflux_KefC"/>
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        <property type="entry name" value="Na+/solute_symporter_sf"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="PTHR46157:SF3"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
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        <property type="entry name" value="KUPTAKETRKA"/>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0050">Antiport</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="49"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="72"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="111"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="193"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="225"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="295"/>
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    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="12">
        <location>
            <begin position="336"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB60308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="555" mass="60943" checksum="F7E4A93C09A6C6E5" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KA4</accession>
    <name>DNAJ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaJ</name>
        <name type="ordered locus">SDY_0014</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaJ family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABB60254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001118468.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401742.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KA4"/>
    <dbReference type="SMR" id="Q32KA4"/>
    <dbReference type="STRING" id="300267.SDY_0014"/>
    <dbReference type="EnsemblBacteria" id="ABB60254">
        <property type="protein sequence ID" value="ABB60254"/>
        <property type="gene ID" value="SDY_0014"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0014"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.14"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_6"/>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_1000085302" description="Chaperone protein DnaJ">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="197"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="1">
        <location>
            <begin position="131"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <sequence length="376" mass="41072" checksum="E4CD8C3143C93576" modified="2005-12-06" version="1">MAKQDYYEILGVSKTAEEREIKKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEVLTDSQKRAAYDQYGHAAFEQGGMGGGGFGGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMELTLEEAVRGVTKEIRIPTLEECDVCHGSGAKPGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCNKCHGHGRVERSKTLSVKIPAGVDTGDRIRLAGEGEVGEHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNEKQKQLLQELQESFGGPTGEHNSPRSKSFFDGVKKFFDDLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Q9</accession>
    <name>Q326Q9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spa15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spa15</name>
        <name evidence="1" type="ordered locus">SDY_P186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378994.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406187.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Q9"/>
    <dbReference type="EnsemblBacteria" id="ABB64699">
        <property type="protein sequence ID" value="ABB64699"/>
        <property type="gene ID" value="SDY_P186"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P186"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5738"/>
    <dbReference type="HOGENOM" id="CLU_125441_0_0_6"/>
    <dbReference type="OMA" id="TIMEGCQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003065">
        <property type="entry name" value="Invas_SpaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03519">
        <property type="entry name" value="Invas_SpaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01305">
        <property type="entry name" value="SSPAKPROTEIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="133" mass="15215" checksum="FA6119DA7B501E7C" modified="2005-12-06" version="1">MSNINLVQLVRDSLFTIGCPPSIITDLDSHSAITISLDNMPAINIALVNEQVMLWANFDAPSDVKLQSSAYNILNLMLMNFSYSINELVELHRSDEYLQLRVVIKDDYVHDGIVFAEILHEFYQRMEILNEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q326S7</accession>
    <name>Q326S7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IpgB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ipgB1</name>
        <name evidence="1" type="ordered locus">SDY_P168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001166524.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406169.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326S7"/>
    <dbReference type="EnsemblBacteria" id="ABB64681">
        <property type="protein sequence ID" value="ABB64681"/>
        <property type="gene ID" value="SDY_P168"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P168"/>
    <dbReference type="HOGENOM" id="CLU_1320171_0_0_6"/>
    <dbReference type="OMA" id="IDEMAIH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004959">
        <property type="entry name" value="Bac_effector_IpgB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03278">
        <property type="entry name" value="IpaB_EvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="208" mass="23632" checksum="A06C3422021E2A29" modified="2005-12-06" version="1">MQILNKILPQVEFAIPRPSFNSLSHNKLVKKILSVFNLKQRFPHKNFGCPVNINKIRDSVIDKIKDSNSGDQLFCWMSQERTSYVSSMINRSIDEMAIHNGVVLTSDNKKNIFAAIEKKFPDIKLDEKSAQTSISHTALNEIASSGLRAKILKRYSSDMDLFNTQMKDLTNLVSSSVYDKIFNESTKVLQIEISAEVLKAVYRQSNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q326V9</accession>
    <name>Q326V9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein CopB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">repB</name>
        <name evidence="7" type="ordered locus">SDY_P136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Sd197</strain>
            <plasmid evidence="8">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000083819.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406137.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326V9"/>
    <dbReference type="SMR" id="Q326V9"/>
    <dbReference type="EnsemblBacteria" id="ABB64649">
        <property type="protein sequence ID" value="ABB64649"/>
        <property type="gene ID" value="SDY_P136"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P136"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5692"/>
    <dbReference type="HOGENOM" id="CLU_180887_0_0_6"/>
    <dbReference type="OMA" id="RERKMRS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006276">
        <property type="term" value="P:plasmid maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019661">
        <property type="entry name" value="RepA2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10723">
        <property type="entry name" value="RepB-RCR_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="1" id="KW-0615">Plasmid copy control</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="10038" checksum="F7AD85B2C211CBF8" modified="2005-12-06" version="1">MSQTENAVTSSLSQKRFVRRGKPMTDSEKQMAAVARKRLTHKEIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQRLDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q326W9</accession>
    <name>Q326W9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yigA</name>
        <name evidence="1" type="ordered locus">SDY_P126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004971339.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406127.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326W9"/>
    <dbReference type="EnsemblBacteria" id="ABB64639">
        <property type="protein sequence ID" value="ABB64639"/>
        <property type="gene ID" value="SDY_P126"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P126"/>
    <dbReference type="HOGENOM" id="CLU_185145_0_0_6"/>
    <dbReference type="OMA" id="NGQVWRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="70" mass="8258" checksum="E130255911E2A832" modified="2005-12-06" version="1">MNGFRNSSRNGQVWRYQRAGGRAVILEVSGRWMEAAEAWRRAACVAPRTDWQQFARKRAEHCHRRCRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Y1</accession>
    <name>Q326Y1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS186 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406115.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Y1"/>
    <dbReference type="EnsemblBacteria" id="ABB64627">
        <property type="protein sequence ID" value="ABB64627"/>
        <property type="gene ID" value="SDY_P114"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P114"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5669"/>
    <dbReference type="HOGENOM" id="CLU_049434_1_0_6"/>
    <dbReference type="OMA" id="IVRVYWR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="230" mass="26069" checksum="E6324E512C5F9FFA" modified="2005-12-06" version="1">MGYDPHTCQFTDFELTDSRDAERLDRFAQTADEIRIADRGFGSRPECIRSLAFGEADYIVRVYWRGLRWLTAEGMRFDMMDFLRGLDCGKNGETTVMIGNSGNKKAGAPFPARLIAVSLPPEKALISKTRLLSENRRKGRVVQAETLEAAGHVLLLTSLSEDEYSAEQVADCYRLRWQIELAFKRLKSLLHLDALRAKEPELAKAWIFANLLAAFLIDDIIQPSLDFPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q327A8</accession>
    <name>Q327A8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001178088.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406088.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327A8"/>
    <dbReference type="EnsemblBacteria" id="ABB64600">
        <property type="protein sequence ID" value="ABB64600"/>
        <property type="gene ID" value="SDY_P087"/>
    </dbReference>
    <dbReference type="GeneID" id="58463398"/>
    <dbReference type="KEGG" id="sdy:SDY_P087"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5637"/>
    <dbReference type="HOGENOM" id="CLU_155311_4_1_6"/>
    <dbReference type="OMA" id="QALTAWI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="94" mass="10498" checksum="1737A8ACB94CB086" modified="2005-12-06" version="1">MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAWADSLSTDHPLPVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q327G9</accession>
    <name>Q327G9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS3 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406027.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327G9"/>
    <dbReference type="EnsemblBacteria" id="ABB64539">
        <property type="protein sequence ID" value="ABB64539"/>
        <property type="gene ID" value="SDY_P026"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P026"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5563"/>
    <dbReference type="HOGENOM" id="CLU_027402_18_0_6"/>
    <dbReference type="OMA" id="YFAREPR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="50"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="99" mass="11262" checksum="67B1B85A9DC32B74" modified="2005-12-06" version="1">MTKTVSTSKKTRKQHSPEFCSEALKLAERIGVAAAARELSLYESQLYAWRSKLQQQMTSSERESELAAENARLKRQLAEQAEELAILQKAATYFAKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q327H0</accession>
    <name>Q327H0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IpgB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ipgB2</name>
        <name evidence="1" type="ordered locus">SDY_P025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406026.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327H0"/>
    <dbReference type="EnsemblBacteria" id="ABB64538">
        <property type="protein sequence ID" value="ABB64538"/>
        <property type="gene ID" value="SDY_P025"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P025"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5562"/>
    <dbReference type="HOGENOM" id="CLU_123902_0_0_6"/>
    <dbReference type="OMA" id="NITNNDR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004959">
        <property type="entry name" value="Bac_effector_IpgB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03278">
        <property type="entry name" value="IpaB_EvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="191" mass="21916" checksum="22B9DF0D6AF8FD5F" modified="2005-12-06" version="1">MIIMLGTSFNNFGISLSHKRYFSGKVDEIIRCTMGKRIVKISSTKINTSILSSVSEQIGENITDWKNDEKKVYVSRVVNQCIDKFCAEHSREIGDNLRKQIFKQVEKDYRISLDINAAQSSINHLVSGSSYFKKKMDELCEGMNRSVKNDTTSNVVNLISDQFFEKNVQYIDLKKLRGNMSDYITNLESPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q327K3</accession>
    <name>Q327K3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidoglycan lytic exotransglycosylase</fullName>
            <ecNumber evidence="3">4.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">slt</name>
        <name evidence="9" type="ordered locus">SDY_4653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exolytic cleavage of the (1-&gt;4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.</text>
            <dbReference type="EC" id="4.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.n1" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327K3"/>
    <dbReference type="STRING" id="300267.SDY_4653"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64502">
        <property type="protein sequence ID" value="ABB64502"/>
        <property type="gene ID" value="SDY_4653"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4653"/>
    <dbReference type="HOGENOM" id="CLU_019016_1_1_6"/>
    <dbReference type="OMA" id="RQESAFM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037061">
        <property type="entry name" value="Lytic_TGlycoase_superhlx_L_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012289">
        <property type="entry name" value="Lytic_TGlycosylase_superhlx_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008939">
        <property type="entry name" value="Lytic_TGlycosylase_superhlx_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14718">
        <property type="entry name" value="SLT_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48435">
        <property type="entry name" value="SSF48435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLT_L" evidence="8">
        <location>
            <begin position="416"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="7">
        <location>
            <begin position="492"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="654" mass="74407" checksum="307192191F70844D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q327P9</accession>
    <name>Q327P9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yjiL</name>
        <name evidence="4" type="ordered locus">SDY_4596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405947.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327P9"/>
    <dbReference type="STRING" id="300267.SDY_4596"/>
    <dbReference type="EnsemblBacteria" id="ABB64456">
        <property type="protein sequence ID" value="ABB64456"/>
        <property type="gene ID" value="SDY_4596"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4596"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5444"/>
    <dbReference type="HOGENOM" id="CLU_066597_0_0_6"/>
    <dbReference type="OMA" id="GKGANYF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="7"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="257" mass="27433" checksum="C86CAE020342F811" modified="2005-12-06" version="1">MAVAYSIGIDSGSTATKGILLADGVITRRFLVPTPFRPATAITEAWETLREGLETTPFLTLTGYGRQLVDFADKQVTEISCHGLGARFLAPATRAVIDIGGQDSKVIQLDDDGNLCDFLMNDKCAAGTGRFLEVISRTLGTSVEQLDSITENVRPHAITSMCTVFAESEVISLRSAGVAPEAILAGVINAMARRSANFIARLSCEAPILFTGGVSHCQRFTHMLESHLGMPVQTHPDAQFAGAIGAAVIGQRQRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Q5</accession>
    <name>Q327Q5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_4590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021075.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405941.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Q5"/>
    <dbReference type="STRING" id="300267.SDY_4590"/>
    <dbReference type="EnsemblBacteria" id="ABB64450">
        <property type="protein sequence ID" value="ABB64450"/>
        <property type="gene ID" value="SDY_4590"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4590"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5431"/>
    <dbReference type="HOGENOM" id="CLU_073529_3_1_6"/>
    <dbReference type="OMA" id="MLLDNQH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="158" mass="17684" checksum="664A2446A5C93381" modified="2005-12-06" version="1">MQQLSFLPGNMTPGERSLIQRALKTLDRHLHEPGVAFTSTHAAREWLILNMAGLEREEFRVLYLNNQNQLIAGETLFTGTINRTEVHPREVIKRSLYHNAAAVVLAHNHPSGEVTPSKADRLITERLVQALALVDIRVPDHLIVGGNQVFSFAEHGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q328B0</accession>
    <name>Q328B0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yjdL</name>
        <name evidence="11" type="ordered locus">SDY_4467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000856800.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405836.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328B0"/>
    <dbReference type="STRING" id="300267.SDY_4467"/>
    <dbReference type="EnsemblBacteria" id="ABB64345">
        <property type="protein sequence ID" value="ABB64345"/>
        <property type="gene ID" value="SDY_4467"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4467"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5270"/>
    <dbReference type="HOGENOM" id="CLU_004790_0_0_6"/>
    <dbReference type="OMA" id="CMIFAIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="9"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB64345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="485" mass="53050" checksum="80B157F9FB2F4E69" modified="2005-12-06" version="1">MKTPSQPRAIYYIVAIQIWEYFSFYGMHALLILYLTHQLGFDDNHAISLFSAYASLVYVTPILGGWLADRLLGNRTAVIAGALLMTLGHVVLGIDTNSTFSLYLALAIIICGYGLFKSNISCLLGELYDENDHRRDGGFSLLYAAGNIGSIAAPIACGLAAQWYGWHVGFALAGGGMFIGLLIFLSGHRHFQSTRSMDKKALTSVKFALPVWSWLVVMLCLAPVFFTLLLENDWSGYLLAIVCLIAAQIIARMMIKFPEHRRALWQIVLLMFVGTLFWVLAQQGGSTISLFIDRFMNRQAFNIEVPTALFQSVNAIAVMLAGVVLAWLASPESRGNSTLRVWLKFAFGLLLMTCGFMLLAFDARHAAADGQASMGVMISGLALMGFAELFIDPVAIAQITRLKISGVLTGIYMLATGAVANWLAGVVAQQTTESQISGMAIAAYQRFFSQMGEWTLACVAIIVVLAFAARFLFSTPTNMIQESND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q328H7</accession>
    <name>Q328H7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative antitoxin of osmotically regulated toxin-antitoxin system associated with programmed cell death</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_4391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EcnA/EcnB lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000977757.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405769.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328H7"/>
    <dbReference type="STRING" id="300267.SDY_4391"/>
    <dbReference type="EnsemblBacteria" id="ABB64278">
        <property type="protein sequence ID" value="ABB64278"/>
        <property type="gene ID" value="SDY_4391"/>
    </dbReference>
    <dbReference type="GeneID" id="67414766"/>
    <dbReference type="KEGG" id="sdy:SDY_4391"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5186"/>
    <dbReference type="HOGENOM" id="CLU_193827_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012556">
        <property type="entry name" value="Entericidin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08085">
        <property type="entry name" value="Entericidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220820" evidence="5">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="41" mass="4359" checksum="35FD3CE6B025743C" modified="2005-12-06" version="1">MMKRLIVLVLLASTLLTGCNTARGFGEDIKHLGNSISRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q328V1</accession>
    <name>Q328V1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PmbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pmbA</name>
        <name evidence="6" type="ordered locus">SDY_4253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001162174.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405645.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328V1"/>
    <dbReference type="STRING" id="300267.SDY_4253"/>
    <dbReference type="EnsemblBacteria" id="ABB64154">
        <property type="protein sequence ID" value="ABB64154"/>
        <property type="gene ID" value="SDY_4253"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4253"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5014"/>
    <dbReference type="HOGENOM" id="CLU_026425_0_0_6"/>
    <dbReference type="OMA" id="LYRKSTF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="128"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="242"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="450" mass="48356" checksum="A0628E329D8639CE" modified="2005-12-06" version="1">MALAMKVISQVEAQRKILEEAVSTALELASGKSDGAEVAVSKTTGISVSTRYGEVENVEFNSDGALGITVYHQNRKGSASSTDLSPQAIARTVQAALDIARYTSPDPCAGVADKELLAFDAPDLDLFHPAEVSPDEAIELAARAEQAALQADKRITNTEGGSFNSHYGVKVFGNSHGMLQGYCSTRHSLSSCVIAEENGDMERDYAYTIGRAMSDLQTPEWVGADCARRTLSRLSPRKLSTMKAPVIFANEVATGLFGHLVGAIAGGSVYRKSTFLLDSLGKQILPDWLTIEEHPHLLKGLASTPFDSEGVRTERRDVIKDGILTQWLLTSYSARKLGLKSTGHAGGIHNWRIAGQGLSFEQMLKEMGTGLVVTELMGQGVSAITGDYSRGAAGFWVENGEIQYPVSEITIAGNLKDMWRNIVTVGNDIETRSNIQCGSVLLPEMKIAGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Z9</accession>
    <name>YIDZ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional regulator YidZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidZ</name>
        <name type="ordered locus">SDY_4202</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in anaerobic NO protection.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016439.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405597.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Z9"/>
    <dbReference type="SMR" id="Q328Z9"/>
    <dbReference type="STRING" id="300267.SDY_4202"/>
    <dbReference type="EnsemblBacteria" id="ABB64106">
        <property type="protein sequence ID" value="ABB64106"/>
        <property type="gene ID" value="SDY_4202"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4202"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4942"/>
    <dbReference type="HOGENOM" id="CLU_039613_39_2_6"/>
    <dbReference type="OMA" id="QDNDPGE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08417">
        <property type="entry name" value="PBP2_Nitroaromatics_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01607">
        <property type="entry name" value="HTH_type_YidZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023746">
        <property type="entry name" value="Tscrpt_reg_YidZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037402">
        <property type="entry name" value="YidZ_PBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000291707" description="HTH-type transcriptional regulator YidZ">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="319" mass="36941" checksum="8431B3E21BA36CB8" modified="2005-12-06" version="1">MKKSITTLDLNLLLCLQLLMQERSVTKAAKRMNVTPSAVSKSLAKLRAWFDDPLFVNSPLGLTPTPLMVSMEQNLAEWMQMSNLLLDKPHHQTPRGLKFELAAESPLMMIMLNALSKRLYQRYPQATIKLRNWDYDSLDAITRGEVDIGFSGRESHPRSRELLSSLPLAIDYEVLFSDVPCVWLRKDHPALHEKWDLDTFLRYPHISICWEQSDTWALDNVLQELGRERTIAMSLPEFEQSLFMAAQPDNLLLATAPRYCQYYNQLHQLPLVALPLPFDVSQQKKLEVPFTLLWHKRNSHNPKIVWLRETIKNLYASMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q329F7</accession>
    <name>Q329F7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IAT_beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intimin/invasin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329F7"/>
    <dbReference type="STRING" id="300267.SDY_4138"/>
    <dbReference type="EnsemblBacteria" id="ABB64048">
        <property type="protein sequence ID" value="ABB64048"/>
        <property type="gene ID" value="SDY_4138"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4138"/>
    <dbReference type="HOGENOM" id="CLU_1795177_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024519">
        <property type="entry name" value="IAT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038177">
        <property type="entry name" value="IAT_beta_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11924">
        <property type="entry name" value="IAT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IAT_beta" evidence="2">
        <location>
            <begin position="33"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="160" mass="18185" checksum="CEC4211CC297CA23" modified="2005-12-06" version="1">MPLINSNSLEARNLKAMQMERDGKDPQMQVAEVAQQSGTLLARDMDSEQAASMARGWVASSASAQSTYWLSRWGTARVSLGVDEDFSLKSSSFEFLHPWYETPDNLVFSQHTLHRTDDRTQTNHGIGWRYFTPSWMSGVNMFIDHDLTRYHTRTGMGVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q329G8</accession>
    <name>Q329G8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">SDY_4127</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000940963.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405528.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329G8"/>
    <dbReference type="STRING" id="300267.SDY_4127"/>
    <dbReference type="EnsemblBacteria" id="ABB64037">
        <property type="protein sequence ID" value="ABB64037"/>
        <property type="gene ID" value="SDY_4127"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4127"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4851"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_51_6"/>
    <dbReference type="OMA" id="ANKMEVF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="310"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="404"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="639"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB64037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="754" mass="82148" checksum="8559EE9306A0A026" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q329I2</accession>
    <name>Q329I2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic binding protein component of Pn transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phnD</name>
        <name evidence="4" type="ordered locus">SDY_4112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate/phosphite/phosphonate binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000992010.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405514.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329I2"/>
    <dbReference type="STRING" id="300267.SDY_4112"/>
    <dbReference type="EnsemblBacteria" id="ABB64023">
        <property type="protein sequence ID" value="ABB64023"/>
        <property type="gene ID" value="SDY_4112"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4112"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4836"/>
    <dbReference type="HOGENOM" id="CLU_051472_2_0_6"/>
    <dbReference type="OMA" id="QGMRFDK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015716">
        <property type="term" value="P:organic phosphonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005770">
        <property type="entry name" value="PhnD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017797">
        <property type="entry name" value="Phosphnate-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30043:SF1">
        <property type="entry name" value="PTHR30043:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01098">
        <property type="entry name" value="3A0109s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03431">
        <property type="entry name" value="PhnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220966" evidence="3">
        <location>
            <begin position="27"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="338" mass="37297" checksum="4CF87F4D77B72DD6" modified="2005-12-06" version="1">MNAKIIASLAFTSMFSLSTLLSPAHAEEQEKALNFGIISTESQQNLKPQWTPFLQDMEKKLGVKVNAFFAPDYAGIIQGMRFNKVDIAWYGNLSAMEAVDRANGQVFAQTVAADGSPGYWSVLIVNKDSPINNLSDLLAKRKDLTFGNGDPNSTSGFLVPGYYVFAKNNISASDFKRTVNAGHETNALAVANKQVDVATNNTENLDKLKTSAPEKLKELKVIWKSPLIPGAPIVWRKNLSETTKDKIYDFFMNYGKTPEEKAVLERLGWAPFRASSDLQLVPIRQLALFKEMQGVKSNKGLNGQDKLAKTTEIQAQLDDLDRLNNALRAMSSVSKAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q329P7</accession>
    <name>Q329P7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cysE</name>
        <name evidence="10" type="ordered locus">SDY_4040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001277565.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405449.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329P7"/>
    <dbReference type="STRING" id="300267.SDY_4040"/>
    <dbReference type="EnsemblBacteria" id="ABB63958">
        <property type="protein sequence ID" value="ABB63958"/>
        <property type="gene ID" value="SDY_4040"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4040"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4755"/>
    <dbReference type="HOGENOM" id="CLU_051638_0_1_6"/>
    <dbReference type="OMA" id="HPKIRHG"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010493">
        <property type="entry name" value="Ser_AcTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06426">
        <property type="entry name" value="SATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00971">
        <property type="entry name" value="SATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SATase_N" evidence="9">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="273" mass="29361" checksum="820CEBEF6FCBE883" modified="2005-12-06" version="1">MSCEELEIVWNNIKAEARTLADCEPMLASFYHATLLKHENLGSALSYMLANKLSSPIMPAIAIREVVEEAYAADPEMIASAACDIQAVRTRDPAVDKYSTPLLYLKGFHALQAYRIGHWLWNQGRRALAIFLQNQVSVTFQVDIHPAAKIGRGIMLDHATGIVVGETAVIENDVSILQSVTLGGTGKTSGDRHPKIREGVMIGAGAKILGNIEVGRGAKIGAGSVVLQPVPPHTTAAGVPARIVGKPDSDKPSMDMDQHFNGINHTFEYGDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Q4</accession>
    <name>Q329Q4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_4033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405442.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Q4"/>
    <dbReference type="STRING" id="300267.SDY_4033"/>
    <dbReference type="EnsemblBacteria" id="ABB63951">
        <property type="protein sequence ID" value="ABB63951"/>
        <property type="gene ID" value="SDY_4033"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4033"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4748"/>
    <dbReference type="HOGENOM" id="CLU_015587_1_0_6"/>
    <dbReference type="OMA" id="YKETPQS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008640">
        <property type="entry name" value="Adhesin_Head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008635">
        <property type="entry name" value="Coiled_stalk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024973">
        <property type="entry name" value="ESPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13018">
        <property type="entry name" value="ESPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05658">
        <property type="entry name" value="YadA_head"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05662">
        <property type="entry name" value="YadA_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESPR" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="1">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="2">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="399" mass="38706" checksum="172E5F0757950CE7" modified="2005-12-06" version="1">MNKIFKVIWNPATGSYSVASETAKSRGKKSGRSKLLISALVAGGMFSSFAYADNADGTPVVPAGHNSGNGWVAIGEGSTASQHTGPDGASTAIGNLASALGKYSTSIGARSSAGGDASTALGVKASASGDRGIALGASSISEGNYSMALGVVAVAHGNYASALGVESEADGEKSLALGFKSKSGGIYSIALGAAANASATDAFAVGRESAASGTDSLALGRKSVASAANSIAIGAETEAAENATAVGNNAKAKGTNSMAMGLGSLADKVNTIALGNGSQALADNAIAIGQGNKADGVDAIALGNGSQSRGLNTIALGTASNATGDKSLALGSNSSANGINSVALGADSIADLDNTVSVGNSSLKRKIVNVKNGAIKSDSYDAINGSQLYAISDSVAKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q329R8</accession>
    <name>Q329R8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ordered locus">SDY_4019</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000334094.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405428.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329R8"/>
    <dbReference type="STRING" id="300267.SDY_4019"/>
    <dbReference type="EnsemblBacteria" id="ABB63937">
        <property type="protein sequence ID" value="ABB63937"/>
        <property type="gene ID" value="SDY_4019"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4019"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4732"/>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_6"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="286"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="458"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="609" mass="66904" checksum="6373301513227484" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A11</accession>
    <name>UBIE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE</fullName>
            <ecNumber evidence="1">2.1.1.163</ecNumber>
            <ecNumber evidence="1">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Demethylmenaquinone methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiE</name>
        <name type="ordered locus">SDY_3910</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="1"/>
    <dbReference type="EC" id="2.1.1.201" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000227958.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405335.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A11"/>
    <dbReference type="SMR" id="Q32A11"/>
    <dbReference type="STRING" id="300267.SDY_3910"/>
    <dbReference type="EnsemblBacteria" id="ABB63844">
        <property type="protein sequence ID" value="ABB63844"/>
        <property type="gene ID" value="SDY_3910"/>
    </dbReference>
    <dbReference type="GeneID" id="67414381"/>
    <dbReference type="KEGG" id="sdy:SDY_3910"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4618"/>
    <dbReference type="HOGENOM" id="CLU_037990_0_0_6"/>
    <dbReference type="OMA" id="VRNFENL"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043333">
        <property type="term" value="F:2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="chain" id="PRO_1000056304" description="Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="123"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <sequence length="251" mass="28073" checksum="B1EEE209BDC68F5E" modified="2005-12-06" version="1">MVDKSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRLVGETGKVVLADINESMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTDKDKALRSMYRVLKPGGRLLVLEFSKPIIEPLSKAYDAYSFHVLPRIGSLVANDADSYRYLAESIRMHPDQDTLKAMMQDAGFESVDYYNLTAGVVALHRGYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A15</accession>
    <name>Q32A15_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A15"/>
    <dbReference type="STRING" id="300267.SDY_3906"/>
    <dbReference type="EnsemblBacteria" id="ABB63840">
        <property type="protein sequence ID" value="ABB63840"/>
        <property type="gene ID" value="SDY_3906"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3906"/>
    <dbReference type="HOGENOM" id="CLU_086034_1_0_6"/>
    <dbReference type="OMA" id="MDMRERM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="145" mass="15599" checksum="6DD014BF596ED220" modified="2005-12-06" version="1">MAVKTVAGWIRALRSLATTVQNELTQELKLQEFQDSLKKVEKASLTNLTPELKASMDELRQAAESMKRSYVANDPEKASDEAHTIHNLVVKDNEAAHEGVTPAAAQTQASSPEQKPETTPEPVVKPAADAEPKTAAPSPSSSDKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A57</accession>
    <name>DTD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name type="ordered locus">SDY_3856</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000560980.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405289.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A57"/>
    <dbReference type="SMR" id="Q32A57"/>
    <dbReference type="STRING" id="300267.SDY_3856"/>
    <dbReference type="EnsemblBacteria" id="ABB63798">
        <property type="protein sequence ID" value="ABB63798"/>
        <property type="gene ID" value="SDY_3856"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3856"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4556"/>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_6"/>
    <dbReference type="OMA" id="GVFQAHM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000259312" description="D-aminoacyl-tRNA deacylase">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <sequence length="145" mass="15897" checksum="464170DB0819EC8B" modified="2005-12-06" version="1">MIALIQRVTRASVTVEGEVTGEIGAGLLVLLGVEKDDDEQKANRLCERVLGYRIFSDAEGKMNLNVQQAGGSVLVVSQFTLAADTERGMRPSFSKGASPDRAEALYDYFVERCCQQEMNTQTGRFAADMQVSLVNDGPVTFWLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AC2</accession>
    <name>Q32AC2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS system fructose-like IIB component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">frwD</name>
        <name evidence="5" type="ordered locus">SDY_3788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000323848.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405224.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AC2"/>
    <dbReference type="STRING" id="300267.SDY_3788"/>
    <dbReference type="EnsemblBacteria" id="ABB63733">
        <property type="protein sequence ID" value="ABB63733"/>
        <property type="gene ID" value="SDY_3788"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3788"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4477"/>
    <dbReference type="HOGENOM" id="CLU_013155_2_2_6"/>
    <dbReference type="OMA" id="CISGVAH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="113" mass="12666" checksum="67FF9D0ED814FB72" modified="2005-12-06" version="1">MAYLVAVTACVSGVAHTYMAAERLEKLCQLEKWGISIETQGALGTENRLADEDIRRADVALLITDIELAGAERFEHCRYVQCSIYAFLREPQRVMSAVRKVLSAPQQTHLILE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AE6</accession>
    <name>BTUB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vitamin B12 transporter BtuB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cobalamin receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Outer membrane cobalamin translocator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">btuB</name>
        <name type="ordered locus">SDY_3762</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000591381.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405200.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AE6"/>
    <dbReference type="SMR" id="Q32AE6"/>
    <dbReference type="STRING" id="300267.SDY_3762"/>
    <dbReference type="EnsemblBacteria" id="ABB63709">
        <property type="protein sequence ID" value="ABB63709"/>
        <property type="gene ID" value="SDY_3762"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3762"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4449"/>
    <dbReference type="HOGENOM" id="CLU_008287_18_5_6"/>
    <dbReference type="OMA" id="SYELQWR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01531">
        <property type="entry name" value="BtuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010101">
        <property type="entry name" value="B12_transptr_BtuB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01779">
        <property type="entry name" value="TonB-B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0626">Porin</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0798">TonB box</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1134">Transmembrane beta strand</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000292760" description="Vitamin B12 transporter BtuB">
        <location>
            <begin position="21"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="158"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded" evidence="1">
        <location>
            <begin position="558"/>
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                <person name="Yang J."/>
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                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
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                <person name="Xiong Z."/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="425" mass="46331" checksum="5A7D51F55D2C4C68" modified="2005-12-06" version="1">MKPMHIAMALLSAAMFFVLAGVFMGVQLELDGTKLVVDTASDIRWQWVFIGTAVVFFFQLLRPAFQKGLKSVSGPKFILPAIDGSTVRQKLFLVALLVLAVAWPFMVSRGTVDIATLTMIYIILGLGLNVVVGLSGLLVLGYGGFYAIGAYTFALLNHYYGLGFWTCLPIAGLMAAAAGFLLGFPVLRLRGDYLAIVTLGFGEIVRILLLNNTEITGGPNGISQIPKPTFFGLEFSRTAREGGWDTFSNFFGLKYDPSDRVIFLYLVALLLVVLSLFVINRLLRMPLGRAWEALREDEIACRSLGLSPRRIKLTAFTISAAFAGFAGTLFAARQGFVSPESFTFAESAFVLAIVVLGGMGSQFAVILAAVLLVVSRELMRDFNEYSMLMLGGLMVLMMIWRPQGLLPMTRPQLKLKNGAAKGEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AX4</accession>
    <name>Q32AX4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer membrane protein induced after carbon starvation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">slp</name>
        <name evidence="1" type="ordered locus">SDY_3557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405022.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AX4"/>
    <dbReference type="STRING" id="300267.SDY_3557"/>
    <dbReference type="EnsemblBacteria" id="ABB63531">
        <property type="protein sequence ID" value="ABB63531"/>
        <property type="gene ID" value="SDY_3557"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3557"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4220"/>
    <dbReference type="HOGENOM" id="CLU_100924_0_0_6"/>
    <dbReference type="OMA" id="FIACRAG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004658">
        <property type="entry name" value="OMP_Slp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37530">
        <property type="entry name" value="PTHR37530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03843">
        <property type="entry name" value="Slp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004982">
        <property type="entry name" value="SlP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00752">
        <property type="entry name" value="slp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="199" mass="22240" checksum="9F6D37331CE0E039" modified="2005-12-06" version="1">MVLIFVDKDSNMNMTKGALILSLSFLLAACSSIPQNIKGNNQPDIQKSFVAVHNQPGLYVGQQARFGGKVINVINGKTDTLLEIAVLPLDSYAKPDIEANYQGRLLARQSGFLDPVNYRNHFVTILGTIQGEQPSFINKVPYNFLEVNMQGIQVWHLREVVNTTYNLWDYGYGAFWPEPGWGAPYYTNAVSQVTPELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AX9</accession>
    <name>Q32AX9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">shuT</name>
        <name evidence="3" type="ordered locus">SDY_3552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405017.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AX9"/>
    <dbReference type="STRING" id="300267.SDY_3552"/>
    <dbReference type="TCDB" id="3.A.1.14.18">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63526">
        <property type="protein sequence ID" value="ABB63526"/>
        <property type="gene ID" value="SDY_3552"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3552"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4215"/>
    <dbReference type="HOGENOM" id="CLU_038034_6_0_6"/>
    <dbReference type="OMA" id="PNVGYMR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="78"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="330" mass="36030" checksum="7CEFBDC4D885F991" modified="2005-12-06" version="1">MNRRLYFIYNSNDNHDHSQFDKSSHIMPRIITRPFLFTPLTLCISAVASASKSTVKRKKLFTAVLALSWAFSVTAAERIVVAGGSLTELIYAMGAGERVVGVDETTSYPPETAKLPHIGYWKQLSSEGILSLRPDSVITWQDAGPQIVLDQLRAQKVNVVTLPRVPATLEQMYANIRQLAKTLQVPEQGDALVTQINQRLERVQQNVAAKKAPVKAMFILSAGGSAPQVAGKGSVADAILSLAGAENVATHQQYKSYSAESLIAANPEVIVVTSQMVDGDINRLRSIAGITHTAAWKNQRIITVDQNLILGMGPRIADVVESLHQQLWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B04</accession>
    <name>Q32B04_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yhfG</name>
        <name evidence="1" type="ordered locus">SDY_3524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000736862.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404992.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B04"/>
    <dbReference type="SMR" id="Q32B04"/>
    <dbReference type="STRING" id="300267.SDY_3524"/>
    <dbReference type="EnsemblBacteria" id="ABB63501">
        <property type="protein sequence ID" value="ABB63501"/>
        <property type="gene ID" value="SDY_3524"/>
    </dbReference>
    <dbReference type="GeneID" id="66672757"/>
    <dbReference type="KEGG" id="sdy:SDY_3524"/>
    <dbReference type="HOGENOM" id="CLU_188462_1_0_6"/>
    <dbReference type="OMA" id="RNANFQA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022541">
        <property type="entry name" value="YhfG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10832">
        <property type="entry name" value="DUF2559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="55" mass="6599" checksum="A362E118B012951A" modified="2005-12-06" version="1">MKKLTDKQKSRLWELQRNRNFQASRRLEGVEMPLVTLTAAEALARLEELRSHYER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B32</accession>
    <name>RL4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplD</name>
        <name type="ordered locus">SDY_3495</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000424395.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404964.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B32"/>
    <dbReference type="SMR" id="Q32B32"/>
    <dbReference type="STRING" id="300267.SDY_3495"/>
    <dbReference type="EnsemblBacteria" id="ABB63473">
        <property type="protein sequence ID" value="ABB63473"/>
        <property type="gene ID" value="SDY_3495"/>
    </dbReference>
    <dbReference type="GeneID" id="67463983"/>
    <dbReference type="KEGG" id="sdy:SDY_3495"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4148"/>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_6"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="PRO" id="PR:Q32B32"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000242437" description="50S ribosomal protein L4">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="201" mass="22087" checksum="3A953206B0F083B5" modified="2005-12-06" version="1">MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B37</accession>
    <name>RS3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsC</name>
        <name type="ordered locus">SDY_3490</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000529945.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404959.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B37"/>
    <dbReference type="SMR" id="Q32B37"/>
    <dbReference type="STRING" id="300267.SDY_3490"/>
    <dbReference type="EnsemblBacteria" id="ABB63468">
        <property type="protein sequence ID" value="ABB63468"/>
        <property type="gene ID" value="SDY_3490"/>
    </dbReference>
    <dbReference type="GeneID" id="64727509"/>
    <dbReference type="GeneID" id="67515075"/>
    <dbReference type="KEGG" id="sdy:SDY_3490"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4143"/>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_6"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="PRO" id="PR:Q32B37"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000230727" description="30S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <sequence length="233" mass="25983" checksum="6D0131A285B7AAB3" modified="2005-12-06" version="1">MGQKVHPNGIRLGIVKPWNSTWFANTKEFADNLDSDFKVRQYLTKELAKASVSRIVIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSITSQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRADIDYNTSEAHTTYGVIGVKVWIFKGEILGGMAAVEQPEKPAAQPKKQQRKGRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B65</accession>
    <name>SMG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein Smg</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smg</name>
        <name type="ordered locus">SDY_3461</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Smg family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000460671.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404931.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B65"/>
    <dbReference type="STRING" id="300267.SDY_3461"/>
    <dbReference type="EnsemblBacteria" id="ABB63440">
        <property type="protein sequence ID" value="ABB63440"/>
        <property type="gene ID" value="SDY_3461"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3461"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4114"/>
    <dbReference type="HOGENOM" id="CLU_133242_0_0_6"/>
    <dbReference type="OMA" id="IHNETEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00598">
        <property type="entry name" value="Smg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007456">
        <property type="entry name" value="Smg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38692">
        <property type="entry name" value="PTHR38692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04361">
        <property type="entry name" value="DUF494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000025674" description="Protein Smg">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00598"/>
        </source>
    </evidence>
    <sequence length="157" mass="18457" checksum="A138921B401A03CB" modified="2005-12-06" version="1">MFDVLMYLFETYIHTEAELRVDQDKLEQDLTDAGFDREDIYNALLWLEKLADYQEGLAEPMQLASDPLSMRIYTPEECERLDASCRGFLLFLEQIQVLNLETREMVIERVLALDTAEFDLEDLKWVILMVLFNIPGCENAHQQMEELLFEVNEGMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B83</accession>
    <name>Q32B83_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">accB</name>
        <name evidence="7" type="ordered locus">SDY_3432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000354621.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404913.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B83"/>
    <dbReference type="STRING" id="300267.SDY_3432"/>
    <dbReference type="EnsemblBacteria" id="ABB63422">
        <property type="protein sequence ID" value="ABB63422"/>
        <property type="gene ID" value="SDY_3432"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3432"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4088"/>
    <dbReference type="HOGENOM" id="CLU_016733_3_1_6"/>
    <dbReference type="OMA" id="IKSPIIG"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="73"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="156" mass="16683" checksum="05FFD9FC06F283A3" modified="2005-12-06" version="1">MDIRKIKKLIELVEESGISELEISEGEESVRISRAAPAASFPVMQQAYAAPMMQQPAQSNAAAPATVPSMEAPAAAEISGHIVRSPMVGTFYRTPSPDAKAFIEVGQKVNVGDPLCIVEAMKMMNQIEADKSGTVKAILVESGQPVEFDEPLVVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BA1</accession>
    <name>Q32BA1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1471 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yhcN</name>
        <name evidence="4" type="ordered locus">SDY_3414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000695691.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404895.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BA1"/>
    <dbReference type="STRING" id="300267.SDY_3414"/>
    <dbReference type="EnsemblBacteria" id="ABB63404">
        <property type="protein sequence ID" value="ABB63404"/>
        <property type="gene ID" value="SDY_3414"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3414"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4072"/>
    <dbReference type="HOGENOM" id="CLU_158602_2_2_6"/>
    <dbReference type="OMA" id="NGNYHAT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036275">
        <property type="entry name" value="YdgH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010854">
        <property type="entry name" value="YdgH/BhsA/McbA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07338">
        <property type="entry name" value="DUF1471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159871">
        <property type="entry name" value="SSF159871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220985" description="DUF1471 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1471" evidence="3">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="9162" checksum="B1CC968CFC7896CB" modified="2005-12-06" version="1">MKIKTTVAALSVLSVLSFGALAADSIDAAQAQNREAIGTVSVSGVASSPMDMREMLNKKAEEKGATAYQITEARSGDTWHATAELYK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-24" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BG8</accession>
    <name>RS15_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsO</name>
        <name type="ordered locus">SDY_3344</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000059466.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404828.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BG8"/>
    <dbReference type="SMR" id="Q32BG8"/>
    <dbReference type="STRING" id="300267.SDY_3344"/>
    <dbReference type="EnsemblBacteria" id="ABB63337">
        <property type="protein sequence ID" value="ABB63337"/>
        <property type="gene ID" value="SDY_3344"/>
    </dbReference>
    <dbReference type="GeneID" id="66672933"/>
    <dbReference type="KEGG" id="sdy:SDY_3344"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3998"/>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_6"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000115535" description="30S ribosomal protein S15">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <sequence length="89" mass="10269" checksum="AABDDA6674B99B1C" modified="2005-12-06" version="1">MSLSTEATAKIVSEFGRDANDTGSTEVQVALLTAQINHLQGHFAEHKKDHHSRRGLLRMVSQRRKLLDYLKRKDVARYTQLIERLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BH2</accession>
    <name>Q32BH2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aromatic amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mtr</name>
        <name evidence="11" type="ordered locus">SDY_3340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in transporting aromatic amino acids across the cytoplasmic membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell inner membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000224334.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404824.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BH2"/>
    <dbReference type="EnsemblBacteria" id="ABB63333">
        <property type="protein sequence ID" value="ABB63333"/>
        <property type="gene ID" value="SDY_3340"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3340"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3994"/>
    <dbReference type="HOGENOM" id="CLU_038102_2_1_6"/>
    <dbReference type="OMA" id="LVKYYDR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015173">
        <property type="term" value="F:aromatic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018227">
        <property type="entry name" value="Amino_acid_transport_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013061">
        <property type="entry name" value="Trp/try_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013059">
        <property type="entry name" value="Trp_tyr_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46997">
        <property type="entry name" value="PTHR46997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03222">
        <property type="entry name" value="Trp_Tyr_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00166">
        <property type="entry name" value="AROAAPRMEASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00837">
        <property type="entry name" value="araaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00594">
        <property type="entry name" value="AROMATIC_AA_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="414" mass="44421" checksum="A87B11EC267FE230" modified="2005-12-06" version="1">MATLTTTQTSPSLLGGVVIIGGTIIGAGMFSLPVVMSGAWFFWSMAALIFTWFCMLHSGLMILEANLNYRIGSSFDTITKDLLGKGWNVVNGISIAFVLYILTYAYISASGSILHHTFAEMSLNVPARAAGFGFALLVAFVVWLSTKAVSRMTAIVLGAKVITFFLTFGSLLGHVQPATLFNVAESNASYAPYLLMTLPFCLASFGYHGNVPSLMKYYGKDPKTIVKCLVYGTLMALALYTIWLLATMGNIPRPEFIDIAEKGGNIDVLVQALSGVLNSRSLDLLLVVFSNFAVASSFLGVTLGLFDYLADLFGFDDSAVGRLKTALLTFAPPVVGGLLFPNGFLYAIGYAGLAATIWAAIVPALLARASRKRFGSPKFRVWGGKPMITLILVFGVGNALVHILSSFNLLPVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BI2</accession>
    <name>Q32BI2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yraP</name>
        <name evidence="3" type="ordered locus">SDY_3329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000646039.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404814.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BI2"/>
    <dbReference type="STRING" id="300267.SDY_3329"/>
    <dbReference type="EnsemblBacteria" id="ABB63323">
        <property type="protein sequence ID" value="ABB63323"/>
        <property type="gene ID" value="SDY_3329"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3329"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3982"/>
    <dbReference type="HOGENOM" id="CLU_083606_3_0_6"/>
    <dbReference type="OMA" id="RVKKVHN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221006" evidence="1">
        <location>
            <begin position="23"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="124"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="191" mass="20058" checksum="6DB2A36633B79724" modified="2005-12-06" version="1">MKALSPIAVLISALLLQGCVAAAVVGTAAVGTKAATDPRSVGTQVDDGTLEVRVNSALSKDEQIKKEARINVTTYQGKVLLVGQSPNAELSARAKQIAMGVDGANEVYNEIRQGQPIGLGEASNDTWITTKVRSQLLTSDLVKSSNVKVTTENGEVFLMGLVTEREAKAAADIASRVSGVKRVTTAFTFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BK0</accession>
    <name>Q32BK0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-threonine dehydratase catabolic TdcB</fullName>
            <ecNumber evidence="7">4.3.1.17</ecNumber>
            <ecNumber evidence="7">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">L-serine dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tdcB</name>
        <name evidence="9" type="ordered locus">SDY_3309</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine to yield pyruvate via analogous enamine/imine intermediates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">In the native structure, TdcB is in a dimeric form, whereas in the TdcB-AMP complex, it exists in a tetrameric form (dimer of dimers).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="7"/>
    <dbReference type="EC" id="4.3.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000548347.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404796.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BK0"/>
    <dbReference type="SMR" id="Q32BK0"/>
    <dbReference type="STRING" id="300267.SDY_3309"/>
    <dbReference type="EnsemblBacteria" id="ABB63305">
        <property type="protein sequence ID" value="ABB63305"/>
        <property type="gene ID" value="SDY_3309"/>
    </dbReference>
    <dbReference type="GeneID" id="66672982"/>
    <dbReference type="KEGG" id="sdy:SDY_3309"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3955"/>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_6"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="UniPathway" id="UPA00052">
        <property type="reaction ID" value="UER00507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070689">
        <property type="term" value="P:L-threonine catabolic process to propionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="25"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="329" mass="35232" checksum="E7DF018FCCF743B1" modified="2005-12-06" version="1">MHITYDLPVAIDDIIEAKQRLAGRIYKTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIRGAFNKLSSLTDAEKRKGVVACSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDNFNDTIAKVSEIVEMEGRIFIPPYDDPKVIAGQGTIGLEIMEDLYDVDNVIVPIGGGGLIAGIAVAIKSINPTIRVIGVQSENVHGMAASFHSGEITTHRTTGTLADGCDVSRPGNLTYEIVRELVDDIVLVSEDEIRNSMIALIQRNKVVTEGAGALACAALLSGKLDQYIQNRKTVSIISGGNIDLSRVSQITGFVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BT6</accession>
    <name>Q32BT6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase 4 subunit B</fullName>
            <ecNumber evidence="6">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Topoisomerase IV subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">parE</name>
        <name evidence="8" type="ordered locus">SDY_3210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer composed of ParC and ParE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type II topoisomerase family. ParE type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000195274.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404710.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BT6"/>
    <dbReference type="SMR" id="Q32BT6"/>
    <dbReference type="STRING" id="300267.SDY_3210"/>
    <dbReference type="EnsemblBacteria" id="ABB63219">
        <property type="protein sequence ID" value="ABB63219"/>
        <property type="gene ID" value="SDY_3210"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3210"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3835"/>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_6"/>
    <dbReference type="OMA" id="ASEDIWE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00938">
        <property type="entry name" value="ParE_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005737">
        <property type="entry name" value="TopoIV_B_Gneg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01055">
        <property type="entry name" value="parE_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="7">
        <location>
            <begin position="412"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="110"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="6">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="6">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="6">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="630" mass="70258" checksum="AE44CD797B001F98" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BW9</accession>
    <name>Q32BW9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UbiH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ubiH</name>
        <name evidence="9" type="ordered locus">SDY_3174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000111180.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404677.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BW9"/>
    <dbReference type="STRING" id="300267.SDY_3174"/>
    <dbReference type="EnsemblBacteria" id="ABB63186">
        <property type="protein sequence ID" value="ABB63186"/>
        <property type="gene ID" value="SDY_3174"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3174"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3792"/>
    <dbReference type="HOGENOM" id="CLU_009665_8_1_6"/>
    <dbReference type="OMA" id="KRWFARQ"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008681">
        <property type="term" value="F:2-octaprenyl-6-methoxyphenol hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011295">
        <property type="entry name" value="UbiH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01984">
        <property type="entry name" value="UbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="8">
        <location>
            <begin position="2"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="392" mass="42409" checksum="378EA3D7F89964D8" modified="2005-12-06" version="1">MSVIIVGGGMAGATLALAISRLSHGALPVHLIEATAPESHAHPGFDGRAIALAAGTCQQLARIGVWQSLADCATAITTVHVSDRGHAGFVTLAAEDYQLAALGQVVELHNVGQRLFALLRKAPGVTLHCPDRVANVARTQSHVEVTLECGETLTGRVLVAADGTHSALATVCCVDWQQEPYEQLAVIANVATSVAHEGRAFERFTQHGPLAMLPMSDGRCSLVWCHPLERREEVLSWSDEKFCRELQSAFGWRLGKITHAGKRSAYPLALTHAARSITHRTVLVGNAAQTLHPIAGQGFNLGMRDVMSLAETLTQAQERGEDMGDYGVLCRYQQRRQSDREATIGVTDSLVHLFANRWTPLVVGRNIGLMTMELFTPARDVLAQRTLGWVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BZ2</accession>
    <name>Q32BZ2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BZ2"/>
    <dbReference type="STRING" id="300267.SDY_3150"/>
    <dbReference type="EnsemblBacteria" id="ABB63163">
        <property type="protein sequence ID" value="ABB63163"/>
        <property type="gene ID" value="SDY_3150"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3150"/>
    <dbReference type="HOGENOM" id="CLU_2425298_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="10438" checksum="BED129D7AE2A624B" modified="2005-12-06" version="1">MRHRHPATLSGGETQRVVIACAIAMQPKLLILDEAFSRLTPQASEMLLQRLQHWAFARGSLIILFERHRTPFLNYCQQAWQLQNGALQPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C00</accession>
    <name>Q32C00_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Transketolase</fullName>
            <ecNumber evidence="5 10">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">tktA</name>
        <name evidence="12" type="ordered locus">SDY_3141</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5 10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000098596.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404646.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C00"/>
    <dbReference type="STRING" id="300267.SDY_3141"/>
    <dbReference type="EnsemblBacteria" id="ABB63155">
        <property type="protein sequence ID" value="ABB63155"/>
        <property type="gene ID" value="SDY_3141"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3141"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3750"/>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_6"/>
    <dbReference type="OMA" id="HHTEGIE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="663" mass="72225" checksum="3D7E947841EA0A6E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C13</accession>
    <name>SPRT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein SprT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sprT</name>
        <name type="ordered locus">SDY_3128</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SprT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000858391.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404633.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C13"/>
    <dbReference type="STRING" id="300267.SDY_3128"/>
    <dbReference type="EnsemblBacteria" id="ABB63142">
        <property type="protein sequence ID" value="ABB63142"/>
        <property type="gene ID" value="SDY_3128"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3128"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3738"/>
    <dbReference type="HOGENOM" id="CLU_113336_0_1_6"/>
    <dbReference type="OMA" id="QPHGEEW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00746">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023483">
        <property type="entry name" value="Uncharacterised_SprT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000046541" description="Protein SprT">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="SprT-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00746"/>
        </source>
    </evidence>
    <sequence length="165" mass="19268" checksum="F101A39925D89E0C" modified="2005-12-06" version="1">MKTSRLPIAIQQAVMRRLREKLAQANLKLGCNYPEPKLSYTQRGTSAGTAWLESYEIRLNPVLLLENSEAFIEEVVPHELAHLLVWKHFGRVAPHGKEWKWMMESVLGVPARRTHQFELQSVRRNTFPYRCKCQEHQLTVRRHNRVVRGEAVYRCVHCGEQLVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C52</accession>
    <name>Q32C52_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yghT</name>
        <name evidence="1" type="ordered locus">SDY_3087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000741450.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404594.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C52"/>
    <dbReference type="STRING" id="300267.SDY_3087"/>
    <dbReference type="EnsemblBacteria" id="ABB63103">
        <property type="protein sequence ID" value="ABB63103"/>
        <property type="gene ID" value="SDY_3087"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3087"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3694"/>
    <dbReference type="HOGENOM" id="CLU_102178_0_0_6"/>
    <dbReference type="OMA" id="DVACARK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="234" mass="25808" checksum="A98318D826E719CF" modified="2005-12-06" version="1">MAASPQSITPPLIAVIGIDGSGKSTVCEHLITVVEKYGAAERVHLGKQAGNVGRAVTKLPLMGKSLHKTIERNQVKTAKKLPGPVPALVITAFVARRLLRFRHMLACRRRGLIVLTDRYPQDQIPGAYDGTVFPPNVEGGRFVSWLASQQRKAFHWMASHKPDLVIKLNVDLEVACMRKPDHKRQSLARKIAITPQLTFGGAQLVDIDANRPLEQVLIDAEKAITDFMTARGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C76</accession>
    <name>Q32C76_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yqhD</name>
        <name evidence="4" type="ordered locus">SDY_3063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001058822.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404570.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C76"/>
    <dbReference type="STRING" id="300267.SDY_3063"/>
    <dbReference type="EnsemblBacteria" id="ABB63080">
        <property type="protein sequence ID" value="ABB63080"/>
        <property type="gene ID" value="SDY_3063"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3063"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3668"/>
    <dbReference type="HOGENOM" id="CLU_007207_0_4_6"/>
    <dbReference type="OMA" id="CTMALNG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990362">
        <property type="term" value="F:butanol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08187">
        <property type="entry name" value="BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044731">
        <property type="entry name" value="BDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43633">
        <property type="entry name" value="PTHR43633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="9"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="387" mass="42057" checksum="45EB60011F72C821" modified="2005-12-06" version="1">MNNFNLHTPTRILFGKGAIAGLREQIPHDARVLITYGGGSVKKTGVLDQVLDALKGMDVLEFGGIEPNPAYETLMNAVKLVREQKVTFLLAVGGGSVLDGTKFIAAAANYPENIDPWHILQTGGKEIKSAIPMGCVLTLPATGSESNAGAVISRKTTGDKQAFHSAPVQPVFAVLDPVYTYTLPPRQVANGVVDAFVHTVEQYVTKPVDAKIQDRFAEGILLTLIEDGPKALKEPENYDVRANVMWAATQALNGLIGAGVPQDWATHMLGHELTAMHGLDHAQTLAIVLPALWNEKRDTKRAKLLQYAERVWNITEGSDDERIDAAIAATRNFFEQLGVPTHLSDYGLDGSSIPALLKKLEEHGMTQLGENHDITLDVSRRIYEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CJ2</accession>
    <name>Q32CJ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CJ2"/>
    <dbReference type="STRING" id="300267.SDY_2937"/>
    <dbReference type="EnsemblBacteria" id="ABB62963">
        <property type="protein sequence ID" value="ABB62963"/>
        <property type="gene ID" value="SDY_2937"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2937"/>
    <dbReference type="HOGENOM" id="CLU_023348_3_2_6"/>
    <dbReference type="OMA" id="TEGGCCW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="414" mass="45882" checksum="FA055F27A6517A0C" modified="2005-12-06" version="1">MAMNTIGSWQNHAISLGLPPNTPVKKQIDEFIRRWDNFPIAPERRANPAWAQNTVDGDEINLFDILPLFRLNDGDGGFYLDKACVVSRDPLDPDNFGKQNVGIYRMEVKGKRKLGLQPVPMHDIALHLHKAEERGEDLPIAITLGNDPIITLMGATPLKYDQSEYEMAGALRESSYPSATAPLTCFDVPWGSEVILEGVIESRKREIEGPFGEFTGHYSGGRNMTVVRIDKVSYRTRPIFESLYLGMPWTEIDYLMGPATCVPLYQQLKAEFPEVQAVNAMYTHGLLAIISTKKRYGGFARAVGLRAMTTPHGLGYVKMVIMVDEDVDPFNLPQVMWALSSKVNPSGDLVQLPNMSVLELDPGSSPAGITDKLIIDATTPVAPDNRGHYSQPVVDLPETKAWAEKLTAMLAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CK1</accession>
    <name>Q32CK1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypE</name>
        <name evidence="4" type="ordered locus">SDY_2927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404445.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CK1"/>
    <dbReference type="STRING" id="300267.SDY_2927"/>
    <dbReference type="EnsemblBacteria" id="ABB62954">
        <property type="protein sequence ID" value="ABB62954"/>
        <property type="gene ID" value="SDY_2927"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2927"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3515"/>
    <dbReference type="HOGENOM" id="CLU_049733_0_0_6"/>
    <dbReference type="OMA" id="CGNGGKE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="152"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="322" mass="33731" checksum="73422511E1B10163" modified="2005-12-06" version="1">MQQLINSLFMEAFANPWLAEQEDQARLDLAQLVAEGDRLAFSTDSYVIDPLFFPGGNIGKLAICGTANDVAVSGAIPRYLSCGFILEEGLPMETLKAVVTSMAETARTAGIAIVTGDTKVVQRGAADKLFINTAGMGAIPANIHWGAQTLTAGDVLLVSGTLGDHGATILNLREQLGLDGELVSDCAVLTPLIQTLRDIPGVKALRDATRGGVNAVVHEFAAACGCGIEISESALPVKPAVRGVCELLGLDALNFANEGKLVIAVERNAAEQVLAALHSHPLGKDAALIGEVVERKGVRLAGLYGVKRTLDLPHAEPLPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CM6</accession>
    <name>Q32CM6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system, glucitol/sorbitol-specific IIC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">srlA</name>
        <name evidence="2" type="ordered locus">SDY_2898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000573321.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404420.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CM6"/>
    <dbReference type="STRING" id="300267.SDY_2898"/>
    <dbReference type="EnsemblBacteria" id="ABB62929">
        <property type="protein sequence ID" value="ABB62929"/>
        <property type="gene ID" value="SDY_2898"/>
    </dbReference>
    <dbReference type="GeneID" id="66673429"/>
    <dbReference type="KEGG" id="sdy:SDY_2898"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3481"/>
    <dbReference type="HOGENOM" id="CLU_093147_0_0_6"/>
    <dbReference type="OMA" id="HINPGEY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004699">
        <property type="entry name" value="PTS_IID_sorb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40399">
        <property type="entry name" value="PTHR40399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03608">
        <property type="entry name" value="EII-GUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038321">
        <property type="entry name" value="PTS_glc_srb_IIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00821">
        <property type="entry name" value="EII-GUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51107">
        <property type="entry name" value="PTS_EIIC_TYPE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="187" mass="20580" checksum="86A10715BD9DE287" modified="2005-12-06" version="1">MIETITHGAEWFIGLFQKGGEVFTGMVTGILPLLISLLVIMNALINFIGQHRIERFAQRCAGNPVSRYLLLPCIGTFVFCNPMTLSLGRFMPEKYKPSYYAAASYSCHSMNGLFPHINPGELFVYLGIASGLTTLNLPLGPLAVSYLLVGLVTNFFRGWVTDLTTAIFEKKMGIQLEQKVHLAGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CQ6</accession>
    <name>Q32CQ6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ygaC</name>
        <name evidence="1" type="ordered locus">SDY_2862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000281322.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404390.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CQ6"/>
    <dbReference type="STRING" id="300267.SDY_2862"/>
    <dbReference type="EnsemblBacteria" id="ABB62899">
        <property type="protein sequence ID" value="ABB62899"/>
        <property type="gene ID" value="SDY_2862"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2862"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3440"/>
    <dbReference type="HOGENOM" id="CLU_2095143_0_0_6"/>
    <dbReference type="OMA" id="GICHGFS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018994">
        <property type="entry name" value="DUF2002"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09400">
        <property type="entry name" value="DUF2002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="121" mass="13950" checksum="1DF2BEC79104DA80" modified="2005-12-06" version="1">MYLRPDEVARVLEKVGFTVDVVTQKAYGYRRGENYVYVNREARMGRTALVIHPTLKERSSTLAEPASDIKTCDHYQQFPLYLAGERHEHYGIPHGFSSRVALERYLNGLVMLPISRTCVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CQ8</accession>
    <name>Q32CQ8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-alanine exporter AlaE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">alaE</name>
        <name evidence="6" type="ordered locus">SDY_2860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exports L-alanine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AlaE exporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000492655.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404388.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CQ8"/>
    <dbReference type="STRING" id="300267.SDY_2860"/>
    <dbReference type="EnsemblBacteria" id="ABB62897">
        <property type="protein sequence ID" value="ABB62897"/>
        <property type="gene ID" value="SDY_2860"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2860"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3435"/>
    <dbReference type="HOGENOM" id="CLU_126493_0_0_6"/>
    <dbReference type="OMA" id="ADWHQIA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034639">
        <property type="term" value="F:L-amino acid efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032973">
        <property type="term" value="P:amino acid export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00914">
        <property type="entry name" value="L_Ala_exporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010574">
        <property type="entry name" value="Ala_export_AlaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06610">
        <property type="entry name" value="AlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="149" mass="16930" checksum="0B1D31F498DBF15C" modified="2005-12-06" version="1">MFSPQSRLRHAVADTFAMVVYCSVVNMCIEVFLSGMSFEQSFYSRLVAIPVNILIAWPYGMYRDLFMRAARKVSPSGWIKNLADILAYVTFQSPVYVAILLVVGADWHQIMAAVSSNIVVSMLMGAVYGYFLDYCRRLFKVSHYQQVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D24</accession>
    <name>Q32D24_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yphG</name>
        <name evidence="1" type="ordered locus">SDY_2738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D24"/>
    <dbReference type="STRING" id="300267.SDY_2738"/>
    <dbReference type="EnsemblBacteria" id="ABB62781">
        <property type="protein sequence ID" value="ABB62781"/>
        <property type="gene ID" value="SDY_2738"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2738"/>
    <dbReference type="HOGENOM" id="CLU_010402_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033396">
        <property type="entry name" value="DUF5107"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17128">
        <property type="entry name" value="DUF5107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="638" mass="71908" checksum="C114A81ADCB3D01B" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DB4</accession>
    <name>Q32DB4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_2637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001111025.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404182.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DB4"/>
    <dbReference type="STRING" id="300267.SDY_2637"/>
    <dbReference type="EnsemblBacteria" id="ABB62691">
        <property type="protein sequence ID" value="ABB62691"/>
        <property type="gene ID" value="SDY_2637"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2637"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3175"/>
    <dbReference type="HOGENOM" id="CLU_1270774_0_0_6"/>
    <dbReference type="OMA" id="ACFYSAN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044870">
        <property type="entry name" value="BMC_CP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030983">
        <property type="entry name" value="EutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009193">
        <property type="entry name" value="EutL_PduB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012290">
        <property type="entry name" value="EutL_PduB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04502">
        <property type="entry name" value="microcomp_EutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51931">
        <property type="entry name" value="BMC_CP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC circularly permuted" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="BMC circularly permuted" evidence="3">
        <location>
            <begin position="114"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="22828" checksum="C808AF65DE235DD9" modified="2005-12-06" version="1">MPALDLIRPSVTAMRVIASVNADFARELKLPPHIRSLGLISADSDDVTYIAADEATKQAMVEVVYGRSLYAGAAHGPSPTAGEVLIMLGGPNPAEVRAGLDAMVAHIENGAAFQWANDAQDTAFLAHVVSRTGSYLSSTAGITLGDPMAYLVAPPLEATYGIDAALKSADVQLVTYVPPPSETNYLAAFLTGSQAACKAACNAFTDAVLEIARNPIQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DD6</accession>
    <name>Q32DD6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS system, glucose-specific IIA component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">crr</name>
        <name evidence="4" type="ordered locus">SDY_2614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000522248.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404160.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DD6"/>
    <dbReference type="STRING" id="300267.SDY_2614"/>
    <dbReference type="EnsemblBacteria" id="ABB62669">
        <property type="protein sequence ID" value="ABB62669"/>
        <property type="gene ID" value="SDY_2614"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2614"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3151"/>
    <dbReference type="HOGENOM" id="CLU_012312_5_1_6"/>
    <dbReference type="OMA" id="HTKHAVG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="3">
        <location>
            <begin position="39"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="169" mass="18250" checksum="E7AE020745531215" modified="2005-12-06" version="1">MGLFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVGKTPVIRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EG4</accession>
    <name>Q32EG4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbA</name>
        <name evidence="7" type="ordered locus">SDY_2206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000857520.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403782.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EG4"/>
    <dbReference type="STRING" id="300267.SDY_2206"/>
    <dbReference type="EnsemblBacteria" id="ABB62291">
        <property type="protein sequence ID" value="ABB62291"/>
        <property type="gene ID" value="SDY_2206"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2206"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2669"/>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_6"/>
    <dbReference type="OMA" id="PFIMYLG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="292" mass="32496" checksum="E2F3CFA0F5DC4BF8" modified="2005-12-06" version="1">MKTRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFQQLLGDGSQWGLNLQYKVQPSPDGLAQAFIIGEEFIGGDDCALVLGDNIFYGHDLPKLMDVAVNKESGATVFAYHVNDPERYGVVEFDKNGTAISLEEKPLQPKSNYAVTGLYFYDNDVVEMAKNLKPSARGELEITDINRIYMEQGRLSVAMMGRGYAWLDTGTHQSLIEASNFIATIEERQGLKVSCLEEIAYRKGFIDAEQVNVLAEPLKKNAYGQYLLKMIKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EH7</accession>
    <name>Q32EH7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase</fullName>
            <ecNumber evidence="1">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable serine/threonine kinase.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378788.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403769.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EH7"/>
    <dbReference type="STRING" id="300267.SDY_2192"/>
    <dbReference type="EnsemblBacteria" id="ABB62278">
        <property type="protein sequence ID" value="ABB62278"/>
        <property type="gene ID" value="SDY_2192"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2192"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2650"/>
    <dbReference type="HOGENOM" id="CLU_022304_0_0_6"/>
    <dbReference type="OMA" id="LADCPWC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016960">
        <property type="entry name" value="YegI-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030823">
        <property type="entry name" value="UCP030823_PK_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR030823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="646" mass="71175" checksum="03A25EA67441F2FC" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EH8</accession>
    <name>Q32EH8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000119076.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403768.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EH8"/>
    <dbReference type="STRING" id="300267.SDY_2191"/>
    <dbReference type="EnsemblBacteria" id="ABB62277">
        <property type="protein sequence ID" value="ABB62277"/>
        <property type="gene ID" value="SDY_2191"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2191"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2649"/>
    <dbReference type="HOGENOM" id="CLU_066842_1_1_6"/>
    <dbReference type="OMA" id="CQDAHHW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="253" mass="27209" checksum="DD1D9DC95E95D726" modified="2005-12-06" version="1">MSWRLVYASAVGTSHISADLPCQDACQMQVVCLNDQQPLLSVFVADGAGSVSQGGEGAMLAINEAMAYVSQKVQHGELGLNDVLATDIVLTIRQRLFAEAEAKALAVRDFACTFMGLISSPNGTLIMQIGDGGVVVDLGHGLQLPLTPMVGEYANMTHFITDEDAVSRLETFASTERAHKVAAFTDGIQRLALNMLDNSPHVPFFTPFFNGLASATQEQLDLLPELLKQFLSSPAVNERTDDDKTLALALWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EL3</accession>
    <name>Q32EL3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Penicillin-binding protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pbpG</name>
        <name evidence="11" type="ordered locus">SDY_2154</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403733.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EL3"/>
    <dbReference type="SMR" id="Q32EL3"/>
    <dbReference type="STRING" id="300267.SDY_2154"/>
    <dbReference type="MEROPS" id="S11.002"/>
    <dbReference type="EnsemblBacteria" id="ABB62242">
        <property type="protein sequence ID" value="ABB62242"/>
        <property type="gene ID" value="SDY_2154"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2154"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2604"/>
    <dbReference type="HOGENOM" id="CLU_027070_0_3_6"/>
    <dbReference type="OMA" id="WDIKLTK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220683" evidence="9">
        <location>
            <begin position="29"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="33"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="313" mass="34245" checksum="E1544EF352FEFA97" modified="2005-12-06" version="1">MLIMPKFRVSLFSLALMLAVPFAPQAVAKTAAATTASQPEIASGSAMIVDLNTNKVIYSNHPDLVRPIASISKLMTAMVVLDARLPLDEKLKVDISQTPEMKGVYSRVRLNSEISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMNAKAKSLGMNNTRFVEPTGLSVHNVSTARDLTKLLIASKQYPLIGQLSTTREDMATFSNPTYTLPFRNTNHLVYRDNWNIQLTKTGFTNAAGHCLVMRTVINNKPVALVVMDAFGKYTHFADASRLRTWIETGKVMPVPAAALSYKKQKAAQMAAAGQTAQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EM2</accession>
    <name>Q32EM2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative seritonin transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yohK</name>
        <name evidence="6" type="ordered locus">SDY_2145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000968198.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403724.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EM2"/>
    <dbReference type="STRING" id="300267.SDY_2145"/>
    <dbReference type="EnsemblBacteria" id="ABB62233">
        <property type="protein sequence ID" value="ABB62233"/>
        <property type="gene ID" value="SDY_2145"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2145"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2592"/>
    <dbReference type="HOGENOM" id="CLU_082099_3_0_6"/>
    <dbReference type="OMA" id="AQFVHFM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005261">
        <property type="entry name" value="CHP00659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PTHR30249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00659">
        <property type="entry name" value="TIGR00659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="231" mass="24483" checksum="02622750E33607D0" modified="2005-12-06" version="1">MMANIWWSLPLTLIVFFAARKLAARYKFPLLNPLLVAMVVIIPFLMLTGISYDSYFKGSEVLNDLLQPAVVALAYPLYEQLHQIRARWKSIITICFIGSMVAMVTGTSVALLMGASPEIAASILPKSVTTPIAMAVGGSIGGIPAISAVCVIFVGILGAVFGHTLLNAMHIRTKAARGLAMGTASHALGTARCAELDYQEGAFSSLALVLCGIITSLIAPFLFPIILAVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EN2</accession>
    <name>Q32EN2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_0465</name>
        <name evidence="4" type="ordered locus">SDY_2134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402162.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403714.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60673">
        <property type="protein sequence ID" value="ABB60673"/>
        <property type="gene ID" value="SDY_0465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62223">
        <property type="protein sequence ID" value="ABB62223"/>
        <property type="gene ID" value="SDY_2134"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0465"/>
    <dbReference type="KEGG" id="sdy:SDY_2134"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2575"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="GHYLSIK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14956" checksum="F0657ACD6C754B56" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EP9</accession>
    <name>Q32EP9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000627470.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403697.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EP9"/>
    <dbReference type="STRING" id="300267.SDY_2116"/>
    <dbReference type="EnsemblBacteria" id="ABB62206">
        <property type="protein sequence ID" value="ABB62206"/>
        <property type="gene ID" value="SDY_2116"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2116"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2548"/>
    <dbReference type="HOGENOM" id="CLU_064455_0_0_6"/>
    <dbReference type="OMA" id="MQIGWTI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020049">
        <property type="entry name" value="DUF2184"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09950">
        <property type="entry name" value="DUF2184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029202">
        <property type="entry name" value="UCP029202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="313" mass="34285" checksum="D9ACEB6D52B6239A" modified="2005-12-06" version="1">MITFDQATVDSSGAFLIGELERLDQTLNLPLVGYTWSRDIQLREDVSIADDISSWTNTSFAAAGTGANPNGKNWVGKDSTAIAGVNVDIGKSGNPLNLWGMELGWTVIELQAAQQVGRPIDTQKYDGMQLKWQMDNDEQVYVGDSALNLKGLVTLDGVPVNNAAKTWATSTPDEIRASINQVLSDAWAASGYSVVPRDLLILPEQFALLSSIIVSSAGNQSLLTYLQTNTISYHQNGVPLNIRAVKWLKGRGVGNKDRMVAYTNDKKYVRYPLVPLQSVPVQYRGLYQIVTYYGKLGAVEPVYKETISYVDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ER7</accession>
    <name>Q32ER7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yceO</name>
        <name evidence="2" type="ordered locus">SDY_2097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403679.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ER7"/>
    <dbReference type="EnsemblBacteria" id="ABB62188">
        <property type="protein sequence ID" value="ABB62188"/>
        <property type="gene ID" value="SDY_2097"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2097"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2522"/>
    <dbReference type="HOGENOM" id="CLU_212603_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF2770"/>
    </dbReference>
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        <property type="entry name" value="DUF2770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="46" mass="5897" checksum="A421E92048BA8AD1" modified="2005-12-06" version="1">MRPFLQEYLMRRLLHYLINNIREHLMLYLFLWGLLAIMDLIYVFYF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F31</accession>
    <name>YOBH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein YobH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">yobH</name>
        <name type="ordered locus">SDY_1974</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001211011.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403565.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F31"/>
    <dbReference type="STRING" id="300267.SDY_1974"/>
    <dbReference type="EnsemblBacteria" id="ABB62074">
        <property type="protein sequence ID" value="ABB62074"/>
        <property type="gene ID" value="SDY_1974"/>
    </dbReference>
    <dbReference type="GeneID" id="66674284"/>
    <dbReference type="KEGG" id="sdy:SDY_1974"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2383"/>
    <dbReference type="HOGENOM" id="CLU_179882_0_0_6"/>
    <dbReference type="OMA" id="TAQYVHS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025611">
        <property type="entry name" value="YobH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13996">
        <property type="entry name" value="YobH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000259712" description="Uncharacterized protein YobH">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="79" mass="8514" checksum="C0ED523F42DC145E" modified="2005-12-06" version="1" precursor="true">MRFIIRTVMLIALVWIGLLLSGYGVLIGSKENAAGLGLQCTYLTARGTSTVQYLHTKSGFLGITDCPLLRKSNIVVDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F52</accession>
    <name>Q32F52_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-asparagine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ansP</name>
        <name evidence="8" type="ordered locus">SDY_1952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403544.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F52"/>
    <dbReference type="STRING" id="300267.SDY_1952"/>
    <dbReference type="EnsemblBacteria" id="ABB62053">
        <property type="protein sequence ID" value="ABB62053"/>
        <property type="gene ID" value="SDY_1952"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1952"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2357"/>
    <dbReference type="HOGENOM" id="CLU_007946_9_0_6"/>
    <dbReference type="OMA" id="QVPYAGI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="52"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="516" mass="56245" checksum="711EF4890D72BC29" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F59</accession>
    <name>Q32F59_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Psp operon transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pspF</name>
        <name evidence="7" type="ordered locus">SDY_1941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F59"/>
    <dbReference type="STRING" id="300267.SDY_1941"/>
    <dbReference type="EnsemblBacteria" id="ABB62046">
        <property type="protein sequence ID" value="ABB62046"/>
        <property type="gene ID" value="SDY_1941"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1941"/>
    <dbReference type="HOGENOM" id="CLU_000445_0_7_6"/>
    <dbReference type="OMA" id="YHQFRGL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014317">
        <property type="entry name" value="Transcription_activator_PspF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02974">
        <property type="entry name" value="phageshock_pspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="13"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="330" mass="37562" checksum="1642CF800E6E3249" modified="2005-12-06" version="1">MANFIMAEYKDNLLGEANSFLEVLEQVSHLAPLDKPVLIIGERGTGKELIASRLHYLSSRWQGPFISLNCAALNENLLDSELFGHEAGAFTGAQKRHPGRFERADGGTLFLDELATAPMMVQEKLLRVIEYGELERVGGSQPLQVNVRLVCATNADLPAMVNEGTFRADLLDRLAFDVVQLPPLRERESDIMLMAEHFSIQMCREIKLPLFPGFTERARETLLNYRWPGNIRELKNVVERSVYRHGTSDYPLDDIIIDPFKRRPPEEANAVSENTSLPTLPLDLREFQMQQEKELLQLSLQQGKYNQKHAAELLGLTYHQFRALLKKHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FC8</accession>
    <name>Q32FC8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FC8"/>
    <dbReference type="STRING" id="300267.SDY_1868"/>
    <dbReference type="EnsemblBacteria" id="ABB61977">
        <property type="protein sequence ID" value="ABB61977"/>
        <property type="gene ID" value="SDY_1868"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1868"/>
    <dbReference type="HOGENOM" id="CLU_2195148_0_0_6"/>
    <dbReference type="OMA" id="IALCVMR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006726">
        <property type="entry name" value="PHBA_efflux_AaeB/fusaric-R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04632">
        <property type="entry name" value="FUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="108" mass="11528" checksum="C357F6439F9EEF16" modified="2005-12-06" version="1">MVLAQFALVQGHADAIALCVMRYALRNTIAMCLALTVAYYLNLDEPYWAMTSAAVVSFPTVGGVISKSLGRIAGSLLGAIAALLLAGHTLNEPWFFLLSMSAWLGFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FD2</accession>
    <name>Q32FD2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">slyB</name>
        <name evidence="2" type="ordered locus">SDY_1864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000597196.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403464.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FD2"/>
    <dbReference type="SMR" id="Q32FD2"/>
    <dbReference type="STRING" id="300267.SDY_1864"/>
    <dbReference type="EnsemblBacteria" id="ABB61973">
        <property type="protein sequence ID" value="ABB61973"/>
        <property type="gene ID" value="SDY_1864"/>
    </dbReference>
    <dbReference type="GeneID" id="66674467"/>
    <dbReference type="KEGG" id="sdy:SDY_1864"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2243"/>
    <dbReference type="HOGENOM" id="CLU_090265_3_1_6"/>
    <dbReference type="OMA" id="GCAYNSS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rick_17kDa_Anti" evidence="1">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="155" mass="15602" checksum="543EB8A4069A5FA3" modified="2005-12-06" version="1">MIKRVLVVSMVGLSLVGCVNNDTLSGDVYTASEAKQVQNVSYGTIVNVRPVQIQGGDDSNVIGAIGGAVLGGFLGNTVGGGTGRSLATAAGAVAGGVAGQGVQSAMNKTQGVELEIRKDDGNTIMVVQKQGNTRFSPGQRVVLASNGSQVTVSPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FI7</accession>
    <name>IHFA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integration host factor subunit alpha</fullName>
            <shortName evidence="1">IHF-alpha</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ihfA</name>
        <name evidence="1" type="synonym">himA</name>
        <name type="ordered locus">SDY_1807</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001229265.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403409.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FI7"/>
    <dbReference type="SMR" id="Q32FI7"/>
    <dbReference type="STRING" id="300267.SDY_1807"/>
    <dbReference type="EnsemblBacteria" id="ABB61918">
        <property type="protein sequence ID" value="ABB61918"/>
        <property type="gene ID" value="SDY_1807"/>
    </dbReference>
    <dbReference type="GeneID" id="67415582"/>
    <dbReference type="KEGG" id="sdy:SDY_1807"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2179"/>
    <dbReference type="HOGENOM" id="CLU_105066_1_3_6"/>
    <dbReference type="OMA" id="IYVRGFG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13835">
        <property type="entry name" value="IHF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00380">
        <property type="entry name" value="IHF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005684">
        <property type="entry name" value="IHF_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00987">
        <property type="entry name" value="himA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000277779" description="Integration host factor subunit alpha">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="99" mass="11354" checksum="278AC82BCD79D754" modified="2005-12-06" version="1">MALTKAEMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENASPKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FN0</accession>
    <name>Q32FN0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator LYSR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403366.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FN0"/>
    <dbReference type="STRING" id="300267.SDY_1758"/>
    <dbReference type="EnsemblBacteria" id="ABB61875">
        <property type="protein sequence ID" value="ABB61875"/>
        <property type="gene ID" value="SDY_1758"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1758"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2117"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_0_6"/>
    <dbReference type="OMA" id="HLYSEQV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="58"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="351" mass="38295" checksum="BC4FFC43F5BFD7C8" modified="2005-12-06" version="1">MISPRKHQYYPFCCNMIALIVNNILQSSYHNQTTSLVSDTASFLTSLMEKNSLFSQRIRLRHLHTFVAVAQQGTLGRAAETLNLSQPALSKTLNELEQLTGARLFERGRQGAQLTLPGEQFLTHAVRVLDAINTAGQSLNRKEGPNNDVVRVGALPTAALGILPSVIGQFHQQQKETTLQVATMSNPMILAGLKTGEIDIGIGRMSDPELMTGLNYELLFLESLKLVVCPNHPLLQENVTLSRVLEWPVVVSPEGTAPRQHSDALVQSQGCIETLSASLSRQLTVEYDYVWFVPSGAVKDDLRHATLVALPVPGHGAGEPIGILTRVDATFSSGCQLMINAIRKSVMPLIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FR6</accession>
    <name>NUDL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uncharacterized Nudix hydrolase NudL</fullName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nudL</name>
        <name type="ordered locus">SDY_1719</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. PCD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000456725.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403330.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FR6"/>
    <dbReference type="SMR" id="Q32FR6"/>
    <dbReference type="STRING" id="300267.SDY_1719"/>
    <dbReference type="EnsemblBacteria" id="ABB61839">
        <property type="protein sequence ID" value="ABB61839"/>
        <property type="gene ID" value="SDY_1719"/>
    </dbReference>
    <dbReference type="GeneID" id="66674298"/>
    <dbReference type="KEGG" id="sdy:SDY_1719"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2073"/>
    <dbReference type="HOGENOM" id="CLU_040940_5_2_6"/>
    <dbReference type="OMA" id="YYIWGAT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009132">
        <property type="term" value="P:nucleoside diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01592">
        <property type="entry name" value="Nudix_NudL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000059">
        <property type="entry name" value="NUDIX_hydrolase_NudL_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023735">
        <property type="entry name" value="Nudix_NudL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01293">
        <property type="entry name" value="NUDIX_COA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000315584" description="Uncharacterized Nudix hydrolase NudL">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nudix box">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01592"/>
        </source>
    </evidence>
    <sequence length="192" mass="21464" checksum="54CAFB50BF52F5A2" modified="2005-12-06" version="1">MEYRSLTLDDFLSRFQLLRPQINRETLNHRQAAVLIPIVRRPQPGLLLTQRSIHLRKHAGQVAFPGGAVDDTDASVIAAALREAEEEVAIPPSAVEVIGVLPPVDSVTGYQVTPVVGIIPPDLPYRASEDEVSAVFEMPLAQALHLGRYHPLDIYRRGDSHRVWLSWYEQYFVWGMTAGIIRELALQIGVKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-24" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FU7</accession>
    <name>YEAL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0756 membrane protein YeaL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yeaL</name>
        <name type="ordered locus">SDY_1687</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0756 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000460711.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403299.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FU7"/>
    <dbReference type="STRING" id="300267.SDY_1687"/>
    <dbReference type="EnsemblBacteria" id="ABB61808">
        <property type="protein sequence ID" value="ABB61808"/>
        <property type="gene ID" value="SDY_1687"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1687"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2034"/>
    <dbReference type="HOGENOM" id="CLU_125889_0_0_6"/>
    <dbReference type="OMA" id="SKGINWG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01874">
        <property type="entry name" value="UPF0756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007382">
        <property type="entry name" value="UPF0756_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38452">
        <property type="entry name" value="PTHR38452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04284">
        <property type="entry name" value="DUF441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000388937" description="UPF0756 membrane protein YeaL">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01874"/>
        </source>
    </evidence>
    <sequence length="148" mass="15348" checksum="85E291E1B7EA826D" modified="2005-12-06" version="1">MFDVTLLILLGLAALGFISHNTTVAVSILVLIIVRVTPLSTFFPWIEKQGLSIGIIILTIGVMAPIASGTLPPSTLIHSFLNWKSLVAIAVGVIVYWLGGRGVTLMGSQLQLVAGLLVGTVLGVALFRGVPVGPLIAAGLVSLIVGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G28</accession>
    <name>Q32G28_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative resistance / regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydeA</name>
        <name evidence="8" type="ordered locus">SDY_1599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403218.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G28"/>
    <dbReference type="STRING" id="300267.SDY_1599"/>
    <dbReference type="EnsemblBacteria" id="ABB61727">
        <property type="protein sequence ID" value="ABB61727"/>
        <property type="gene ID" value="SDY_1599"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1599"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1921"/>
    <dbReference type="HOGENOM" id="CLU_001265_61_1_6"/>
    <dbReference type="OMA" id="SAHFTAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="352" mass="37651" checksum="8E4E4E2A91F3C319" modified="2005-12-06" version="1">MQTAQVGIMLTIYAWVVALMSLPFMLMTSQVERRKLLICLFVVFIASHVLSFLSWSFTVLVISRIGVAFAHAIFWSITASLAICMAPAGKRAQALSLIATGTALAMVLGLPLGRIVGQYFGWRMTFFAIGIGALITLLCLIKLLPLLPSEHSGSLKSLPLLFRRPALMSIYLLTVVVVTAHYTAYSYIEPFVQNIAGFSANFATALLLLLGGAGIIGSVIFGKLGNQYASALVSTAIALLLVCLALLLPAANSEIHLGVLSIFWGIAMMIIGLGMQVKVLALAPDATDVAMALFSGIFNIGIGAGALVGNQVSLHWSMSMIGYVGAVPAFAALIWSIIIFRRWPVTLEEQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G50</accession>
    <name>Q32G50_SHIDS</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">SDY_1572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        <lineage>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G50"/>
    <dbReference type="EnsemblBacteria" id="ABB61705">
        <property type="protein sequence ID" value="ABB61705"/>
        <property type="gene ID" value="SDY_1572"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_197140_0_0_6"/>
    <dbReference type="OMA" id="LMLEYTH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="70" mass="8184" checksum="37D6DEC0DF9CF2B0" modified="2005-12-06" version="1">MLLCGRLQESLTRYFVLCQILMLEYTHANGITILTINKELMHQFTFNRKAKLAVNVNSFFILFMVMPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G96</accession>
    <name>Q32G96_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">SDY_1522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        <lineage>
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            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G96"/>
    <dbReference type="STRING" id="300267.SDY_1522"/>
    <dbReference type="EnsemblBacteria" id="ABB61659">
        <property type="protein sequence ID" value="ABB61659"/>
        <property type="gene ID" value="SDY_1522"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1522"/>
    <dbReference type="HOGENOM" id="CLU_100821_0_0_6"/>
    <dbReference type="OMA" id="TIWFNAW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221094" evidence="1">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="148" mass="16705" checksum="21A10102A6E3E6AA" modified="2005-12-06" version="1">MMRHCGWLLGLLSLFSLATHASDWQEIKNEAKGQTIWFNAWGGDTAINRYLDWVSGEMKTHYAINLKIVRLADAADAVKRIQTEAAAGRKTGGSVDLLWVNGENFRTLKEPNLLQTDWAETLPNWRYVDTQLPVREDFSVPTEGAESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GA2</accession>
    <name>Q32GA2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000085233.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403144.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GA2"/>
    <dbReference type="STRING" id="300267.SDY_1515"/>
    <dbReference type="EnsemblBacteria" id="ABB61653">
        <property type="protein sequence ID" value="ABB61653"/>
        <property type="gene ID" value="SDY_1515"/>
    </dbReference>
    <dbReference type="GeneID" id="66674345"/>
    <dbReference type="KEGG" id="sdy:SDY_1515"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1813"/>
    <dbReference type="HOGENOM" id="CLU_170184_0_0_6"/>
    <dbReference type="OMA" id="CCIYQDQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009971">
        <property type="entry name" value="DUF1496"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07383">
        <property type="entry name" value="DUF1496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221102" evidence="1">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="9947" checksum="A59386395C507267" modified="2005-12-06" version="1">MSRALFAVVLAFPLIALANPHYRPDVEVNVPPEVFSSGGQSAQPCTQCCVYQDKNYSEGAVIKAEGILLQCQRDDKTLSTNPLVWRRVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GJ1</accession>
    <name>Q32GJ1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
            <ecNumber evidence="2">2.7.7.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24898"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="2.7.7.65"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403055.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GJ1"/>
    <dbReference type="STRING" id="300267.SDY_1420"/>
    <dbReference type="EnsemblBacteria" id="ABB61564">
        <property type="protein sequence ID" value="ABB61564"/>
        <property type="gene ID" value="SDY_1420"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1420"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1690"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_16_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="99" mass="10969" checksum="E8061682EA19E478" modified="2005-12-06" version="1">MSVKLRLPHCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GT9</accession>
    <name>YCIC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0259 membrane protein YciC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yciC</name>
        <name type="ordered locus">SDY_1319</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0259 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000028547.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402957.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GT9"/>
    <dbReference type="STRING" id="300267.SDY_1319"/>
    <dbReference type="EnsemblBacteria" id="ABB61466">
        <property type="protein sequence ID" value="ABB61466"/>
        <property type="gene ID" value="SDY_1319"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1319"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1566"/>
    <dbReference type="HOGENOM" id="CLU_073287_0_0_6"/>
    <dbReference type="OMA" id="FFRNQFV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01067">
        <property type="entry name" value="UPF0259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009627">
        <property type="entry name" value="UPF0259"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000064533" description="UPF0259 membrane protein YciC">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01067"/>
        </source>
    </evidence>
    <sequence length="247" mass="26389" checksum="DE68CA2FB530E8DE" modified="2005-12-06" version="1">MSITAQSVYRDTGNFFRNQFMTILLVSLLCAFITVVLGHVFSPSDAQLAQLNDGVPVSGSSGLFDLVQNMSPEQQQILLQASAASTFSGLIGNAILAGGVILIIQLVSAGQRVSALRAIGASAPILPKLFILIFLTTLLVQIGIMLVVVPGIIMAILLAPAPVMLVQDKMGVFASMRSSMRLTWANMRLVAPAVLSWLLAKTLLLLFASSFAALTPEIGAVLANTLSNLISAVLLIYLFRLYMLIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H19</accession>
    <name>Q32H19_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative outer membrane receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prrA</name>
        <name evidence="9" type="ordered locus">SDY_1235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378673.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402877.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H19"/>
    <dbReference type="STRING" id="300267.SDY_1235"/>
    <dbReference type="EnsemblBacteria" id="ABB61386">
        <property type="protein sequence ID" value="ABB61386"/>
        <property type="gene ID" value="SDY_1235"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1235"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1465"/>
    <dbReference type="HOGENOM" id="CLU_008287_8_2_6"/>
    <dbReference type="OMA" id="VPYDGYV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221104" evidence="6">
        <location>
            <begin position="23"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="38"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="242"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="656" mass="73655" checksum="183EBA837F3DA959" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H51</accession>
    <name>Q32H51_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402845.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H51"/>
    <dbReference type="EnsemblBacteria" id="ABB61354">
        <property type="protein sequence ID" value="ABB61354"/>
        <property type="gene ID" value="SDY_1201"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1201"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1422"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15306" checksum="1652B5E04755451A" modified="2005-12-06" version="1">MALICELGEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H56</accession>
    <name>Q32H56_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402840.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H56"/>
    <dbReference type="STRING" id="300267.SDY_1196"/>
    <dbReference type="EnsemblBacteria" id="ABB61349">
        <property type="protein sequence ID" value="ABB61349"/>
        <property type="gene ID" value="SDY_1196"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1196"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1415"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_9_6"/>
    <dbReference type="OMA" id="FMSIKIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="108" mass="12357" checksum="239DAC0784DD059E" modified="2005-12-06" version="1">MPVHLSAPMKKRNFSAEFKRESAQLVVDQNYTVADAAKAMDVGLSTMTRWVKQLRDERQGKTPKASPITPEQIEIRELRKKLQRIEMENEILKKATALLMSDSLNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H94</accession>
    <name>Q32H94_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isochorismatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000891605.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402802.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H94"/>
    <dbReference type="STRING" id="300267.SDY_1154"/>
    <dbReference type="EnsemblBacteria" id="ABB61311">
        <property type="protein sequence ID" value="ABB61311"/>
        <property type="gene ID" value="SDY_1154"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1154"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1358"/>
    <dbReference type="HOGENOM" id="CLU_2450101_0_0_6"/>
    <dbReference type="OMA" id="IGWSADY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="8919" checksum="C232601D4B2C3623" modified="2005-12-06" version="1">MLELNAKTTALVVIDLQEGILPFAGGPHTADEVVNRAGKLAAKFRASGQPVFLVRIGWSADYAEALKQPVDAPVTLFVPLIMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HF3</accession>
    <name>Q32HF3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flagellar secretion chaperone FliS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fliS</name>
        <name evidence="7" type="ordered locus">SDY_1090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FliS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000270670.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402743.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HF3"/>
    <dbReference type="STRING" id="300267.SDY_1090"/>
    <dbReference type="EnsemblBacteria" id="ABB61252">
        <property type="protein sequence ID" value="ABB61252"/>
        <property type="gene ID" value="SDY_1090"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1090"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1280"/>
    <dbReference type="HOGENOM" id="CLU_080373_1_0_6"/>
    <dbReference type="OMA" id="EFRDTWK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039090">
        <property type="entry name" value="Flis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="136" mass="14961" checksum="9D8FA686195A8C8A" modified="2005-12-06" version="1">MYAAKGTQAYAQIGVESAVMSASQQQLVTMLFDGVLSALVRARLFMQGNNQQGKGVSLSKAINIIENGLRVSLDEESKDELTQNLIALYSYMVRRLLQANLRNDVSAVEEVEALMRNIADAWKESLLSPSLIQDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HK1</accession>
    <name>Q32HK1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 2-component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yedW</name>
        <name evidence="6" type="ordered locus">SDY_1039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HK1"/>
    <dbReference type="STRING" id="300267.SDY_1039"/>
    <dbReference type="EnsemblBacteria" id="ABB61204">
        <property type="protein sequence ID" value="ABB61204"/>
        <property type="gene ID" value="SDY_1039"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1039"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_6"/>
    <dbReference type="OMA" id="GHVVECS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006291">
        <property type="entry name" value="PcoR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01387">
        <property type="entry name" value="cztR_silR_copR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="232" mass="26224" checksum="FF0AA2091E2B5509" modified="2005-12-06" version="1">MNQAVSITYDLWHIIFMKILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRTAKQTPVICLTARDSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHALNSTLEISGLRMDSVSQSVSRDNISITLTRKEFQLLWLLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKVDDPFPVMLPISRTCVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HU5</accession>
    <name>Q32HU5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inner membrane protein YccF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yccF</name>
        <name evidence="3" type="ordered locus">SDY_0936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001261242.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402601.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HU5"/>
    <dbReference type="STRING" id="300267.SDY_0936"/>
    <dbReference type="EnsemblBacteria" id="ABB61110">
        <property type="protein sequence ID" value="ABB61110"/>
        <property type="gene ID" value="SDY_0936"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0936"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1084"/>
    <dbReference type="HOGENOM" id="CLU_120384_0_0_6"/>
    <dbReference type="OMA" id="GVYALWP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="148" mass="16274" checksum="D32F968ABF679126" modified="2005-12-06" version="1">MRTVLNILNFVLGGFATTLGWLLATLVSIVLIFTLPLTRSCWEITKLSLVPYGNEAIHVNELNPAGKNVLLNTGGTVLNIFWLIFFGWWLCLMHIATGIAQCISIIGIPVGIANFKIAAIALWPVGRRVVSVETAQAAREANARRRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I14</accession>
    <name>Q32I14_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">O6-methylguanine-DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ada</name>
        <name evidence="14" type="ordered locus">SDY_0863</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000786384.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402532.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I14"/>
    <dbReference type="STRING" id="300267.SDY_0863"/>
    <dbReference type="EnsemblBacteria" id="ABB61041">
        <property type="protein sequence ID" value="ABB61041"/>
        <property type="gene ID" value="SDY_0863"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0863"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.997"/>
    <dbReference type="HOGENOM" id="CLU_000445_52_0_6"/>
    <dbReference type="OMA" id="RFAIGQC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006304">
        <property type="term" value="P:DNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016221">
        <property type="entry name" value="Bifunct_regulatory_prot_Ada"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000409">
        <property type="entry name" value="Ada"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="13">
        <location>
            <begin position="85"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor from methylphosphotriester" evidence="10">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine" evidence="10">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000409-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000409-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000409-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB61041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="354" mass="39223" checksum="4DB85C6E25E88DE5" modified="2005-12-06" version="1">MKNATCLTDDQRWQSVLARDPNADGEFVFAVRTTGIFCRPSCRARHALRENVSFYVNASEALAAGFRPCKRCQPDKANAQQHRLDKITHACRLLEQETPVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLRESLAKGESVTTSILNAGFPDSSSYYRKADETLGMTAKQFRHGGENLAVRYALADCELGRCLVAESERGICAILLGDDDATLISELQLMFPAADNAPADLTFQQHVREVIASLNQRDTPLTLPLDIRGTAFQQQVWQALRTIPCGETVSYQQLANAIGKPKAVRAVASACAANKLAIVIPCHRVVRGDGSLSGYRWGASRKAQLLRREAENEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IA5</accession>
    <name>Q32IA5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH Mu-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IA5"/>
    <dbReference type="STRING" id="300267.SDY_0768"/>
    <dbReference type="EnsemblBacteria" id="ABB60952">
        <property type="protein sequence ID" value="ABB60952"/>
        <property type="gene ID" value="SDY_0768"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0768"/>
    <dbReference type="HOGENOM" id="CLU_155919_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003314">
        <property type="entry name" value="Mu-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02316">
        <property type="entry name" value="HTH_Tnp_Mu_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51702">
        <property type="entry name" value="HTH_MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH Mu-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="15320" checksum="D77ADF50D57969C4" modified="2005-12-06" version="1">MFVSVNELVGLPGMPGTAQGVRYSIKKRASSEHFRRKRAGSKTIEYSIDCLPPITQQALRERHVAQLMATDPQEITTQPPVKRERKQNVVQPVEAYRGSPQLVEERLNALTENQRKVAEALRCTGNSGHYHLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IJ7</accession>
    <name>Q32IJ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000124253.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402349.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IJ7"/>
    <dbReference type="STRING" id="300267.SDY_0672"/>
    <dbReference type="EnsemblBacteria" id="ABB60860">
        <property type="protein sequence ID" value="ABB60860"/>
        <property type="gene ID" value="SDY_0672"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0672"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.785"/>
    <dbReference type="HOGENOM" id="CLU_028036_0_0_6"/>
    <dbReference type="OMA" id="DPGPYYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="456" mass="49030" checksum="437F97F10BCF6E63" modified="2005-12-06" version="1">MARSFKVLSPTAILGYGFPEESFRKAMAESPDLIAVDAGSSDPGPHYLGAGKPFTDRAGVKRDLRYMITAGVQNNIPVVIGTAGGSGAAPHLEWCREIIHEIAQEEHLSFSMALIPADVDKAIVHQALDNGKITALDFVPPLTHDAIDESTYIVAQMGIDPFQRALKEGAQVVLGGRAYDPACFAALPIMQDFDEGLALHCGKILECAAIAATPGSGSDCAMGIIDDNGFTLKTFNPKRKFTETSAAAHTLYEKSDPYFLPGPGGVLNLKGCTFKAVNDGEVYVSGSKHEETPYALKLEGARRVGFRCLTIAGTRDPIMIAGIDKIIDEVKTSVSRNLSLDDDSIRINFHLYGKNGGMGDHEPMQTAGHELGIVLDVVAPTQEIANSVCSLVRSTMLHYGYENRIATAGNLAFPFSPSDIQGGPVYEFSIYHLIEANDALRFDFHIEQVTPEGVQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IN4</accession>
    <name>KDPC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kdpC</name>
        <name type="ordered locus">SDY_0631</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KdpC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019883.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402312.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IN4"/>
    <dbReference type="SMR" id="Q32IN4"/>
    <dbReference type="STRING" id="300267.SDY_0631"/>
    <dbReference type="EnsemblBacteria" id="ABB60823">
        <property type="protein sequence ID" value="ABB60823"/>
        <property type="gene ID" value="SDY_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0631"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.735"/>
    <dbReference type="HOGENOM" id="CLU_077094_2_0_6"/>
    <dbReference type="OMA" id="KYFWPRP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000022314" description="Potassium-transporting ATPase KdpC subunit">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <sequence length="190" mass="20363" checksum="ED0E35D22E057F98" modified="2005-12-06" version="1">MSGLRPAISTFIFLLLITGGVYPLLTTVLGQWWFPWQANGSLIREGDTVRGSALIGQNFTDNGYFQGRPSATAEMPYNPQASGGSNLAVSNPELDKQIAARVAALRAANPDTSTSVPAELVTASASGLDNNITPQAAAWQIPRVAKARNLSVEQLTQLIAKYSQQPLVKYIGQPVVNIVELNLALDKLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IR6</accession>
    <name>Q32IR6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative periplasmic binding transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybeJ</name>
        <name evidence="4" type="ordered locus">SDY_0592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001177084.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402280.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IR6"/>
    <dbReference type="SMR" id="Q32IR6"/>
    <dbReference type="STRING" id="300267.SDY_0592"/>
    <dbReference type="EnsemblBacteria" id="ABB60791">
        <property type="protein sequence ID" value="ABB60791"/>
        <property type="gene ID" value="SDY_0592"/>
    </dbReference>
    <dbReference type="GeneID" id="58389122"/>
    <dbReference type="KEGG" id="sdy:SDY_0592"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.695"/>
    <dbReference type="HOGENOM" id="CLU_019602_0_0_6"/>
    <dbReference type="OMA" id="PNQLDCL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221125" evidence="2">
        <location>
            <begin position="23"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="41"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="302" mass="33349" checksum="B12A02B8354305EC" modified="2005-12-06" version="1">MQLRKPATAILALALSAGLAQADDAAPAAGSTLDKIAKNGVIVVGHRESSVPFSYYDNQQKVVGYSQDYSNAIVEAVKKKLNKPDLQVKLIPITSQNRIPLLQNGTFDFECGSTTNNVERQKQAAFSDTIFVVGTRLLTKKGGDIKDFADLKGKAVVVTSGTTSEVLLNKLNEEQKMNMRIISAKDHGDSFRTLESGRAVAFMMDDALLAGERAKAKKPDNWDIVGKPQSQEAYGCMLRKDDPQFKKLMDDTIAQVQTSGEAEKWFDKWFKNPIPPKNLNMNFELSDEMKALFKEPNDKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J28</accession>
    <name>Q32J28_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J28"/>
    <dbReference type="STRING" id="300267.SDY_0471"/>
    <dbReference type="EnsemblBacteria" id="ABB60679">
        <property type="protein sequence ID" value="ABB60679"/>
        <property type="gene ID" value="SDY_0471"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0471"/>
    <dbReference type="HOGENOM" id="CLU_044571_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="265" mass="29889" checksum="4D3C7062A699DCCE" modified="2005-12-06" version="1">MAQRLLDTNIPLFWLADGRPAYYVEDLSLVDKDDPEASGFIIDSAINIGIRGSLNGYIQPLVTSRILRQIIAGEPLDAETAFKSSEASSKAAWFVDFPGVEISPGSLMIHRVQAERLRLFWLSYSPSLSPATPEKPKAISTAILSPSLPENEYVNLKYYSVKMSELCEKYIRYKRGGKFTGKAENRVREGFSLLVEVMGDSKLVKVDRDYLREYESLLRSIPARRDLAKIRYKINDIHELMVKAKENGDPLMSDNTVRKYGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J44</accession>
    <name>Q32J44_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrAB operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acrR</name>
        <name evidence="3" type="ordered locus">SDY_0455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000101737.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402152.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J44"/>
    <dbReference type="SMR" id="Q32J44"/>
    <dbReference type="STRING" id="300267.SDY_0455"/>
    <dbReference type="EnsemblBacteria" id="ABB60663">
        <property type="protein sequence ID" value="ABB60663"/>
        <property type="gene ID" value="SDY_0455"/>
    </dbReference>
    <dbReference type="GeneID" id="66671234"/>
    <dbReference type="KEGG" id="sdy:SDY_0455"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.538"/>
    <dbReference type="HOGENOM" id="CLU_069356_12_3_6"/>
    <dbReference type="OMA" id="MMEIIFH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013572">
        <property type="entry name" value="Tscrpt_reg_MAATS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08361">
        <property type="entry name" value="TetR_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="215" mass="24767" checksum="CB002F8DC1F682BB" modified="2005-12-06" version="1">MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSFDLKKEARDYVAILLEMYLLCPTLRNPATNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J58</accession>
    <name>Q32J58_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS4 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019467.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402138.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J58"/>
    <dbReference type="STRING" id="300267.SDY_0440"/>
    <dbReference type="EnsemblBacteria" id="ABB60649">
        <property type="protein sequence ID" value="ABB60649"/>
        <property type="gene ID" value="SDY_0440"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0440"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.521"/>
    <dbReference type="HOGENOM" id="CLU_028400_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024473">
        <property type="entry name" value="Transposases_IS4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13006">
        <property type="entry name" value="Nterm_IS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nterm_IS4" evidence="2">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="448" mass="51231" checksum="1C875C452E88FA6E" modified="2005-12-06" version="1">MFPDFFMHIGQALDLVSRYDSLRNPLTSLGDYLDPELISRCLAESGTVTLRKRRLPLEMMVWCIVGMVLERKEPLHQIVNRLDIMLPGNCPFVAPSAVIQARQRLGSEAVRRVFTKTVQLWHNATPHPHWCGLTLLAIDGVFWRTPDTPENNAAFPRQTHAGNPALYPQVKMVCQMELTSHLLTAAAFGTMKNSENELAEQLIEQTGDNTLTLMDKGYYSLGLLNAWSLAGEHRHWMIPLRKRAQYEEIRKLGKGDHLVKLKTSPQARKKWPGLGNEVTARLLTVTRKGKVCHLLTSMTDAMRFPGGEMADLYSHRWEIELGYREIKQTMQLSRLTLRSKKPELVEQELWGVLLAYNLVRYQMIKMAEHLKGYWPNQLSFSESCGMVMRMLMTLQGASPGRIPELMRDLASMGQLVKLPTRRERAFPRAVKERLWKYPTAPKKSQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J88</accession>
    <name>Q32J88_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metal resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybbM</name>
        <name evidence="7" type="ordered locus">SDY_0408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402108.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J88"/>
    <dbReference type="STRING" id="300267.SDY_0408"/>
    <dbReference type="EnsemblBacteria" id="ABB60619">
        <property type="protein sequence ID" value="ABB60619"/>
        <property type="gene ID" value="SDY_0408"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0408"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.485"/>
    <dbReference type="HOGENOM" id="CLU_076147_1_0_6"/>
    <dbReference type="OMA" id="PWYEPQY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="PTHR30028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00245">
        <property type="entry name" value="TIGR00245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="268" mass="29278" checksum="3AB38E192A42E632" modified="2005-12-06" version="1">MPEKCRKHAMNSHNITNESLALALMLVVVAILISHKEKLALEKDILWSVGRAIIQLIIVGYVLKYIFSVDDASLTLLMMLFICFNAAWNAQKRSKYIAKAFISSFIAITVGAGITLAVLILSGSIEFIPMQVIPIAGMIAGNAMVAVGLCYNNLGQRVISEQQQIQEKLSLGATPKQASAILIRDSIRAALIPTVDSAKTVGLVSLPGMMSGLIFAGIDPVKAIKYQIMVTFMLLSTASLSTIIACYLTYRKFYNSRHQLVVTQLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JG4</accession>
    <name>Q32JG4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yajD</name>
        <name evidence="2" type="ordered locus">SDY_0324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000974813.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402032.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JG4"/>
    <dbReference type="STRING" id="300267.SDY_0324"/>
    <dbReference type="EnsemblBacteria" id="ABB60543">
        <property type="protein sequence ID" value="ABB60543"/>
        <property type="gene ID" value="SDY_0324"/>
    </dbReference>
    <dbReference type="GeneID" id="66671291"/>
    <dbReference type="KEGG" id="sdy:SDY_0324"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.373"/>
    <dbReference type="HOGENOM" id="CLU_136125_1_0_6"/>
    <dbReference type="OMA" id="CHDNEHQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="115" mass="13364" checksum="04D99E2E3FBAA0C7" modified="2005-12-06" version="1">MAIIPKNYARLESGYREKALKIYPWVCGRCSREFVYSNLRELTVHHIDHDHTNNPEDGSNWELLCLYCHDHEHSKYTEADQYGTTVIAGEDAQKDVGEAKYNPFADLKAMMNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JS5</accession>
    <name>Q32JS5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dnaE</name>
        <name evidence="11" type="ordered locus">SDY_0200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001294745.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401921.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JS5"/>
    <dbReference type="STRING" id="300267.SDY_0200"/>
    <dbReference type="EnsemblBacteria" id="ABB60432">
        <property type="protein sequence ID" value="ABB60432"/>
        <property type="gene ID" value="SDY_0200"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0200"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.231"/>
    <dbReference type="HOGENOM" id="CLU_001600_0_2_6"/>
    <dbReference type="OMA" id="NECRRMG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="10">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1160" mass="129907" checksum="41D13D785A9C2B9A" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JZ7</accession>
    <name>Q32JZ7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">ftsZ</name>
        <name evidence="8" type="ordered locus">SDY_0125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000462776.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401849.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JZ7"/>
    <dbReference type="SMR" id="Q32JZ7"/>
    <dbReference type="STRING" id="300267.SDY_0125"/>
    <dbReference type="EnsemblBacteria" id="ABB60360">
        <property type="protein sequence ID" value="ABB60360"/>
        <property type="gene ID" value="SDY_0125"/>
    </dbReference>
    <dbReference type="GeneID" id="66671615"/>
    <dbReference type="KEGG" id="sdy:SDY_0125"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.144"/>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_6"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="12"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="206"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="20"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="383" mass="40324" checksum="B3A53340367DBBA0" modified="2005-12-06" version="1">MFEPMELTNDAVIKVIGVGGGGGNAVEHMVRERIEGVEFFAVNTDAQALRKTAVGQTIQIGSGITKGLGAGANPEVGRNAADEDRDALRAALEGADMVFIAAGMGGGTGTGAAPVVAEVAKDLGILTVAVVTKPFNFEGKKRMAFAEQGITELSKHVDSLITIPNDKLLKVLGRGISLLDAFGAANDVLKGAVQGIAELITRPGLMNVDFADVRTVMSEMGYAMMGSGVASGEDRAEEAAEMAISSPLLEDIDLSGARGVLVNITAGFDLRLDEFETVGNTIRAFASDNATVVIGTSLDPDMNDELRVTVVATGIGMDKRPEITLVTNKQVQQPVMDRYQQHGMAPLTQEQKPVAKVVNDNAPQTAKEPDYLDIPAFLRKQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K13</accession>
    <name>Q32K13_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FruR leader peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fruL</name>
        <name evidence="1" type="ordered locus">SDY_0109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001303787.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K13"/>
    <dbReference type="EnsemblBacteria" id="ABB60344">
        <property type="protein sequence ID" value="ABB60344"/>
        <property type="gene ID" value="SDY_0109"/>
    </dbReference>
    <dbReference type="GeneID" id="66671631"/>
    <dbReference type="KEGG" id="sdy:SDY_0109"/>
    <dbReference type="HOGENOM" id="CLU_3412513_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="28" mass="3291" checksum="43719B4B1C84E07A" modified="2005-12-06" version="1">MRNLQPNMSRWAFFAKSVGTWNKSSCRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K20</accession>
    <name>LEU1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="1">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuA</name>
        <name type="ordered locus">SDY_0101</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000082853.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401826.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K20"/>
    <dbReference type="SMR" id="Q32K20"/>
    <dbReference type="STRING" id="300267.SDY_0101"/>
    <dbReference type="EnsemblBacteria" id="ABB60337">
        <property type="protein sequence ID" value="ABB60337"/>
        <property type="gene ID" value="SDY_0101"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0101"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.120"/>
    <dbReference type="HOGENOM" id="CLU_022158_0_1_6"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000149297" description="2-isopropylmalate synthase">
        <location>
            <begin position="1"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01151"/>
        </source>
    </evidence>
    <sequence length="523" mass="57314" checksum="C3ADE0DAB889851A" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K26</accession>
    <name>Q32K26_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiamine-binding periplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tbpA</name>
        <name evidence="8" type="ordered locus">SDY_0095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020873.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401820.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K26"/>
    <dbReference type="STRING" id="300267.SDY_0095"/>
    <dbReference type="EnsemblBacteria" id="ABB60331">
        <property type="protein sequence ID" value="ABB60331"/>
        <property type="gene ID" value="SDY_0095"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0095"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.111"/>
    <dbReference type="HOGENOM" id="CLU_026974_6_0_6"/>
    <dbReference type="OMA" id="PTTNWMY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13545">
        <property type="entry name" value="PBP2_TbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005967">
        <property type="entry name" value="ThiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01276">
        <property type="entry name" value="thiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220901" description="Thiamine-binding periplasmic protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="327" mass="36177" checksum="354C8DDE10E17082" modified="2005-12-06" version="1">MLKKCLPLLLLCTAPVFAKPVLTVYTYDSFAADWGPGPVVKKAFEADCNCELKLVALEDGVSLLNRLRMEGKNSKADVVLGLDNNLLDAASKTGLFAKSGVAADAVNVPGGWNNDTFVPFDYGYFAFVYDKNKLKNPPQSLKELVESDQNWRVIYQEPRTSTPGLGLLLWMQKVYGDDAPQAWQKLAKKTVTVTKGWSEAYGLFLKGESDLVLSYTTSPAYHILEEKKDNYAAANFSEGHYLQVEVAARTAASKQPELAQKFLQFMVSPAFQNAIPTGNWMYPVANVTLPAGFEKLTKPATTLEFTPAEVAAQRQAWISEWQRAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q326N7</accession>
    <name>Q326N7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS629 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406209.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326N7"/>
    <dbReference type="EnsemblBacteria" id="ABB64721">
        <property type="protein sequence ID" value="ABB64721"/>
        <property type="gene ID" value="SDY_P208"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P208"/>
    <dbReference type="HOGENOM" id="CLU_2208273_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="107" mass="11574" checksum="E7DB816E29891860" modified="2005-12-06" version="1">MARCTVARLMAVMGLAGVLRGKKVRTTISRKAVAAGDRVNRHQGNVPRTPGGPQRLVYVVSAADKDKHTSAVPSALRQRCPQGFYPVQRYGSPRLTDELCALVTTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Q0</accession>
    <name>Q326Q0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406196.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Q0"/>
    <dbReference type="EnsemblBacteria" id="ABB64708">
        <property type="protein sequence ID" value="ABB64708"/>
        <property type="gene ID" value="SDY_P195"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P195"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5747"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_1_6"/>
    <dbReference type="OMA" id="VQISMTE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="206" mass="23642" checksum="46D7A0B6AA999FB2" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELADNGIIVGRDRLARLRKELRLHCKQKRKFRATTSSDHNLPVTPNLLNQNFTPTAPNQVWVADITYIATREGWLYLAGVKDVYTCEIVGYAMGERMTKELTGKALFMALRSQHPPAGLIHHSDRGSQYCAYDYRVMQEQSGLKTSMSRKGNCYDNAPMEIFWGTLKNESLSHYRFKSRDISSAYGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q326R2</accession>
    <name>Q326R2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type 3 secretion system secretin</fullName>
            <shortName evidence="7">T3SS secretin</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mxiD</name>
        <name evidence="7" type="synonym">sctC</name>
        <name evidence="10" type="ordered locus">SDY_P183</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Sd197</strain>
            <plasmid evidence="11">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle. This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope. Forms a stable homooligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7 8">Cell outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the bacterial secretin family. T3SS SctC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000714402.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406184.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326R2"/>
    <dbReference type="EnsemblBacteria" id="ABB64696">
        <property type="protein sequence ID" value="ABB64696"/>
        <property type="gene ID" value="SDY_P183"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P183"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5735"/>
    <dbReference type="HOGENOM" id="CLU_022474_4_0_6"/>
    <dbReference type="OMA" id="VWYDDGA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02219">
        <property type="entry name" value="Type_III_secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004845">
        <property type="entry name" value="T2SS_GspD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003522">
        <property type="entry name" value="T3SS_OM_pore_YscC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01337">
        <property type="entry name" value="TYPE3OMGPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02516">
        <property type="entry name" value="type_III_yscC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00875">
        <property type="entry name" value="T2SP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="7 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026397102" description="Type 3 secretion system secretin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="9">
        <location>
            <begin position="185"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="566" mass="63106" checksum="DBFF1B4C011E6340" modified="2005-12-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Y2</accession>
    <name>Q326Y2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406114.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Y2"/>
    <dbReference type="EnsemblBacteria" id="ABB64626">
        <property type="protein sequence ID" value="ABB64626"/>
        <property type="gene ID" value="SDY_P113"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P113"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5668"/>
    <dbReference type="HOGENOM" id="CLU_2810064_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7767" checksum="24A316DA8C5C036E" modified="2005-12-06" version="1">MRVSELPDYLRHHWPELKAQLLSGRYRPSPVRRVSILKPGGGERLLGIQMVVDRFIQQAMMQVLQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q327A4</accession>
    <name>Q327A4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative plasmid stable inheritance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406092.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327A4"/>
    <dbReference type="EnsemblBacteria" id="ABB64605">
        <property type="protein sequence ID" value="ABB64605"/>
        <property type="gene ID" value="SDY_P092"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P092"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5641"/>
    <dbReference type="HOGENOM" id="CLU_074773_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009440">
        <property type="entry name" value="Plasmid_segregation_ParM/StbA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06406">
        <property type="entry name" value="StbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="StbA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="165" mass="18178" checksum="4401C3BD6A543BE7" modified="2005-12-06" version="1">MPESIPAGYEVLQELDELDSLLIIDLGGTTLDISQVMGKLSGISKIYGDSSLGVSLVTSAVKDTLSLARTKGSSYLADDIIIHKKDNNYLKQRINDENKISIVTEAMNEALRKLEQRVLNTLNEFSSYTHVMVIGGGAELICDTVKKTHRFVMNVFSKPITLNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q327G8</accession>
    <name>Q327G8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS3 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406028.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327G8"/>
    <dbReference type="EnsemblBacteria" id="ABB64540">
        <property type="protein sequence ID" value="ABB64540"/>
        <property type="gene ID" value="SDY_P027"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P027"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5564"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="MYSPMER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038965">
        <property type="entry name" value="InsF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46889:SF1">
        <property type="entry name" value="PTHR46889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="125"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="289" mass="33524" checksum="249B9B0FB8F96A77" modified="2005-12-06" version="1">MKYVFIEKHQAEFSIKAMCRVLRVARSGWYTWCQRRTGISPRQQFCQHCDSVVLAAAFTRSKQRYGAPRLTDELRAQGYHFNVKTVAASLRRQGLRAKGSRKFSPVSYRAHGLPVSENLLEQDFYASGPNQKWAGDITYLRTDEGWLYLAVVIDLWSRAVIGWSMSPRLTAQLACDALQMALWRRKRPRNVIVHSDRGSQYCSADYQALLKWHNLRGSMSAKGCCYDNACVESFFHSLKVECLHGEHFISREIMWATVFNYIECDYNRWRRHSWCGGLSPEQFENQNLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q327K9</accession>
    <name>LPLA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoate-protein ligase A</fullName>
            <ecNumber evidence="1">6.3.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipoate--protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lplA</name>
        <name type="ordered locus">SDY_4647</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000105898.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405987.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327K9"/>
    <dbReference type="SMR" id="Q327K9"/>
    <dbReference type="STRING" id="300267.SDY_4647"/>
    <dbReference type="EnsemblBacteria" id="ABB64496">
        <property type="protein sequence ID" value="ABB64496"/>
        <property type="gene ID" value="SDY_4647"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4647"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5509"/>
    <dbReference type="HOGENOM" id="CLU_022986_0_1_6"/>
    <dbReference type="OMA" id="RTCPEDD"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01602">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023741">
        <property type="entry name" value="Lipoate_ligase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000069389" description="Lipoate-protein ligase A">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01067"/>
        </source>
    </evidence>
    <sequence length="338" mass="37914" checksum="7384D92F636920B1" modified="2005-12-06" version="1">MSTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEVDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTSIVLNALNALGVSAEASGRNDLVVKTVEGDRKVSGSAYRETKDRGFHHGTLLLNADLSRLANYLNPDKKKLAAKGITSVRSRVTNLTELLPGITHEQVCEAITKAFFAHYGERVEAEIISPDKTPDLPNFAETFARQSSWEWNFGQAPAFSHLLDERFSWGGVELHFDVEKGHITRAQVFTDSLNPAPLEAFAGRLQGCLYRADMLQQECEALLVDFPDQEKELRELSTWIAGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q327N6</accession>
    <name>Q327N6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycoprotein/receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjjA</name>
        <name evidence="2" type="ordered locus">SDY_4614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405960.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327N6"/>
    <dbReference type="STRING" id="300267.SDY_4614"/>
    <dbReference type="EnsemblBacteria" id="ABB64469">
        <property type="protein sequence ID" value="ABB64469"/>
        <property type="gene ID" value="SDY_4614"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4614"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5469"/>
    <dbReference type="HOGENOM" id="CLU_112342_0_0_6"/>
    <dbReference type="OMA" id="AASWQDQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019637">
        <property type="entry name" value="DUF2501"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10696">
        <property type="entry name" value="DUF2501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220799" evidence="1">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="165" mass="17511" checksum="A24BE55A9B34D8F8" modified="2005-12-06" version="1">MMMKTVKHLLCCAIAASALISTGVHAASWKDALSSAASELGNQNNTTQEGGWSLASLTNLLSSGNQALSADNMNNAAGILQYCAKQKLASVTDAENIKNQVLEKLGLNSEEQKEDTNYLDGIQGLLKTKDGQQLNLDNIGTTPLAEKVKTKACDLVLKQGLNFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q327V3</accession>
    <name>Q327V3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjbK</name>
        <name evidence="3" type="ordered locus">SDY_4528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327V3"/>
    <dbReference type="STRING" id="300267.SDY_4528"/>
    <dbReference type="EnsemblBacteria" id="ABB64402">
        <property type="protein sequence ID" value="ABB64402"/>
        <property type="gene ID" value="SDY_4528"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4528"/>
    <dbReference type="HOGENOM" id="CLU_096072_2_1_6"/>
    <dbReference type="OMA" id="DHSHCVH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="191" mass="21620" checksum="C00A68AC4FF68EDA" modified="2005-12-06" version="1">MFFLEHGKVRTFLTPTLRCPMEKTTTQELLAQAEKICAQRNVRLTPQRLEVLRLMSLQDGAISAYDLLDLLREAEPQAKPPTVYRALDFLLEQGFVHKVESTNSYVLCHLFDQPTHTSAMFICDRCGAVKEECAEGVEDIMHTLAAKMGFALRHNVIEAHGLCAACVEVEACRHPEQCQHDHSVQVKKKSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q328J8</accession>
    <name>PRIB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Primosomal replication protein N</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">priB</name>
        <name type="ordered locus">SDY_4370</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds single-stranded DNA at the primosome assembly site (PAS). During primosome assembly it facilitates the complex formation between PriA and DnaT.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the preprimosomal complex composed of one monomer of PriC and DnaT, two monomers of PriA, two dimers of PriB and one hexamer of DnaB. Upon transient interaction with DnaG it forms the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PriB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378947.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405748.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328J8"/>
    <dbReference type="SMR" id="Q328J8"/>
    <dbReference type="STRING" id="300267.SDY_4370"/>
    <dbReference type="EnsemblBacteria" id="ABB64257">
        <property type="protein sequence ID" value="ABB64257"/>
        <property type="gene ID" value="SDY_4370"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4370"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5159"/>
    <dbReference type="HOGENOM" id="CLU_166075_0_0_6"/>
    <dbReference type="OMA" id="CQMPVII"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00720">
        <property type="entry name" value="PriB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023646">
        <property type="entry name" value="Prisomal_replication_PriB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003135">
        <property type="entry name" value="Primosomal_n"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04418">
        <property type="entry name" value="PriB_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0639">Primosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000083300" description="Primosomal replication protein N">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="SSB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00720"/>
        </source>
    </evidence>
    <sequence length="104" mass="11429" checksum="3722468925C2F1A4" modified="2005-12-06" version="1">MTNRLVLSGTVCRTPLRKVSPSGIPHCQFVLEHRSVQEEAGFHRQAWCQMPVIVSGHENQAITHSITVGSSITVQGFISCYKAKNGLSKMVLHAEQIELIDSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q328X6</accession>
    <name>Q328X6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartokinase</fullName>
            <ecNumber evidence="10">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lysC</name>
        <name evidence="13" type="ordered locus">SDY_4227</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001290339.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405620.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328X6"/>
    <dbReference type="STRING" id="300267.SDY_4227"/>
    <dbReference type="EnsemblBacteria" id="ABB64129">
        <property type="protein sequence ID" value="ABB64129"/>
        <property type="gene ID" value="SDY_4227"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4227"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4978"/>
    <dbReference type="HOGENOM" id="CLU_009116_6_0_6"/>
    <dbReference type="OMA" id="LMSCGEV"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04258">
        <property type="entry name" value="AAK_AKiii-LysC-EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041745">
        <property type="entry name" value="AKiii-LysC-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Asp_kin"/>
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    </dbReference>
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        <property type="entry name" value="SSF53633"/>
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    </dbReference>
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        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="12">
        <location>
            <begin position="313"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
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            <position position="119"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="9">
        <location>
            <begin position="221"/>
            <end position="222"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB64129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="449" mass="48726" checksum="3A4F6ACCFE1DB8C7" modified="2005-12-06" version="1">MSEIVVSKFGGTSVADFDAMNRSADIVLSDANVRLVVLSASAGITNLLVALAEGLEPSERFEKLDAIRNIQFAILERLRYPNVIREEIERLLENITVLTEAAALATSPALTDELVSHGELMSTLLFVEILRERDVQAQWFDVRKVMRTNDRFGRAEPDVAALAELAALQLLPRLNEGLVITQGFIGSENKGRTTTLGRGGSDYTAALLAEALHASRVDIWTDVPGIYTTDPRVVSAAKRIDEIAFAEAAEMATFGAKVLHPATLLPTVRSDIPVFVGSSKDPRAGGTLVCNKTENPPLFRALALRRNQTLLTLHSLNMLHSRGFLAEVFGILARHNISVDLITTSEVSVALTLDTTGSTSTDDTLLTQSLLMELSALCRVEVEEGLALVALIGNDLSKACGVGKEVFGVLEPFNIRMICYGASSHNLCFLVPGEDAEQVVQKLHFNLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Z0</accession>
    <name>Q328Z0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yibF</name>
        <name evidence="3" type="ordered locus">SDY_4211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_000779791.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Z0"/>
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    <dbReference type="EnsemblBacteria" id="ABB64115">
        <property type="protein sequence ID" value="ABB64115"/>
        <property type="gene ID" value="SDY_4211"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4211"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4951"/>
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    <dbReference type="OMA" id="VDIGTIA"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
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        <property type="entry name" value="GST_C"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034343">
        <property type="entry name" value="YibF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF12">
        <property type="entry name" value="PTHR42673:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="83"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="202" mass="22502" checksum="BFEA179262249D67" modified="2005-12-06" version="1">MKLVGSYTSPFVRKLSILLLEKGITFEFINELPYNADNGVAQFNPLGKVPVLVTEEGECWFDSPIIAEYIELMNVAPAMLPRDPLESLRVRKIEALADGIMDAGLVSVREQARPAAQQSEDELLRQREKINRSLDVLEGYLVDGTLKTDTVNLATIAIACAVGYLNFLRVAPGWCVDRPHLVKLVENLFSRESFARTEPPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Z7</accession>
    <name>Q328Z7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aromatic amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tnaB</name>
        <name evidence="9" type="ordered locus">SDY_4204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in transporting aromatic amino acids across the cytoplasmic membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell inner membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405599.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Z7"/>
    <dbReference type="EnsemblBacteria" id="ABB64108">
        <property type="protein sequence ID" value="ABB64108"/>
        <property type="gene ID" value="SDY_4204"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4204"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4944"/>
    <dbReference type="HOGENOM" id="CLU_038102_2_1_6"/>
    <dbReference type="OMA" id="FAYVSHM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015173">
        <property type="term" value="F:aromatic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018227">
        <property type="entry name" value="Amino_acid_transport_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013059">
        <property type="entry name" value="Trp_tyr_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46997">
        <property type="entry name" value="PTHR46997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03222">
        <property type="entry name" value="Trp_Tyr_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00166">
        <property type="entry name" value="AROAAPRMEASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00837">
        <property type="entry name" value="araaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="395" mass="43356" checksum="60B2D14E14A5C886" modified="2005-12-06" version="1">MITDVWKYRGKSTVDLAGAWFFWGAFILIIAWFSMLHSGLLLLEANLNYPVGSSFNTITKDLIGNTWNIISGITVAFVLYILTYAYISANGAIISETISMNLGYHANPRIVGICTAIFVASVLWISSLAASRITSLFLGLKIISFVIVFGSFFFQVDYSILRDATSTAAGTSYFPYIFMALPVCLASFGFHGNIPSLIYGKRKDKLIKSVVFGSLLALVIYLFWLYCTMGNIPRESFKAIISSGGNVDSLVKSFLGTKQHGIIEFCLLVFSNLAVASSFFGVTLGLFDYLADLFKIDNSHAGRFKTVLLTFLPPALLYLIFPNGFIYGIGGAGLCATIWAVIIPAVLAIKARKKFPNQMFTVWGSNLIPAIVILFGITVILCWFGNVFNVLPKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q329M5</accession>
    <name>Q329M5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide core biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">waaQ</name>
        <name evidence="2" type="ordered locus">SDY_4062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000360402.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405471.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329M5"/>
    <dbReference type="STRING" id="300267.SDY_4062"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63980">
        <property type="protein sequence ID" value="ABB63980"/>
        <property type="gene ID" value="SDY_4062"/>
    </dbReference>
    <dbReference type="GeneID" id="66672473"/>
    <dbReference type="KEGG" id="sdy:SDY_4062"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4778"/>
    <dbReference type="HOGENOM" id="CLU_038371_3_2_6"/>
    <dbReference type="OMA" id="HMAVTQG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011916">
        <property type="entry name" value="LipoPS_heptosylTferase-III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02201">
        <property type="entry name" value="heptsyl_trn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="352" mass="39447" checksum="FF7623AD1BB9306B" modified="2005-12-06" version="1">MDKPFRRILLIKMRFHGDMLLTTPVISSLKKNYPDAKIDVLLYQDTIPILSENPEINALYGIKNKKAKASEKIANFFHLIKVLRANKYDLIVNLTDQWMVAILVRLLNARVKISQDYHHRQSAFWRKSFTHLVPLQGGNVVESNLSVLTPLGLDSLVKQTTMSYPPASWKRMRRELDHAGVGQNYVVIQPTARQIFKCWDNAKFSAVIDALHARGYEVVLTSGPDKDDLACVNEIAQGCQTPPVTALAGKVTFPELGALIDHAQLFIGVDSAPAHIAAAVNTPLISLFGATDHIFWRPWSNNMIQFWAGDYREMPTRDQRDRNEMYLSVIPAADVIAAVDKLLPSSTTGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q329P4</accession>
    <name>Q329P4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutaredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">grxC</name>
        <name evidence="6" type="ordered locus">SDY_4043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000024392.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405452.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329P4"/>
    <dbReference type="SMR" id="Q329P4"/>
    <dbReference type="STRING" id="300267.SDY_4043"/>
    <dbReference type="EnsemblBacteria" id="ABB63961">
        <property type="protein sequence ID" value="ABB63961"/>
        <property type="gene ID" value="SDY_4043"/>
    </dbReference>
    <dbReference type="GeneID" id="67417613"/>
    <dbReference type="KEGG" id="sdy:SDY_4043"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4758"/>
    <dbReference type="HOGENOM" id="CLU_026126_7_3_6"/>
    <dbReference type="OMA" id="GRTTFPQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03418">
        <property type="entry name" value="GRX_GRXb_1_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011900">
        <property type="entry name" value="GRX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02181">
        <property type="entry name" value="GRX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9137" checksum="5B19A85BB0C9FBEF" modified="2005-12-06" version="1">MANVEIYTKETCPYCHRAKALLSSKGVSFQELPIDGNAAKREEMIKRSGRTTVPQIFIDAQHIGGCDDLYALDARGGLDPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q329R3</accession>
    <name>Q329R3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstA</name>
        <name evidence="11" type="ordered locus">SDY_4024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001251992.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405433.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329R3"/>
    <dbReference type="STRING" id="300267.SDY_4024"/>
    <dbReference type="EnsemblBacteria" id="ABB63942">
        <property type="protein sequence ID" value="ABB63942"/>
        <property type="gene ID" value="SDY_4024"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4024"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4738"/>
    <dbReference type="HOGENOM" id="CLU_033621_2_0_6"/>
    <dbReference type="OMA" id="GIARWKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="83"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="296" mass="32302" checksum="EFF7DEC92BC7BB1C" modified="2005-12-06" version="1">MAMVEMQTTAALAESRRKMQARRRLKNRIALTLSMATMAFGLFWLIWILMSTITRGIDGMSLALFTEMTPPPNTEGGGLANALAGSGLLILWATVFGTPLGIMAGIYLAEYGRKSWLAEVIRFINDILLSAPSIVVGLFVYTIVVAQMEHFSGWAGVIALALLQVPIVIRTTENMLKLVPDSLREAAYALGTPKWKMISAITLKASVSGIMTGILLAIARIAGETAPLLFTALSNQFWSTDMMQPIANLPVTIFKFAMSPFAEWQQLAWAGVLIITLCVLLLNILARVVFVKNKHG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q329S5</accession>
    <name>ATPF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit b</fullName>
            <shortName evidence="1">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpF</name>
        <name type="ordered locus">SDY_4012</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001052219.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405421.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329S5"/>
    <dbReference type="SMR" id="Q329S5"/>
    <dbReference type="STRING" id="300267.SDY_4012"/>
    <dbReference type="EnsemblBacteria" id="ABB63930">
        <property type="protein sequence ID" value="ABB63930"/>
        <property type="gene ID" value="SDY_4012"/>
    </dbReference>
    <dbReference type="GeneID" id="67417723"/>
    <dbReference type="KEGG" id="sdy:SDY_4012"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4725"/>
    <dbReference type="HOGENOM" id="CLU_079215_4_5_6"/>
    <dbReference type="OMA" id="FAWKPIL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000368772" description="ATP synthase subunit b">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <sequence length="156" mass="17264" checksum="51A93C8BEE9AD9DF" modified="2005-12-06" version="1">MNLNATILGQAIAFVLFVLFCMKYVWPPLMAAIEKRQKEIADGLASAERAHKDLDLAKASATDQLKKAKAEAQVIIEQANKRRSQILDEAKAEAEQERTKIVAQAQAEIEAERKRAREELRKQVAILAVAGAEKIIERSVDEAANSDIVDKLVAEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q329T0</accession>
    <name>MNMG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmG</name>
        <name evidence="1" type="synonym">gidA</name>
        <name type="ordered locus">SDY_4007</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000499797.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405416.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329T0"/>
    <dbReference type="SMR" id="Q329T0"/>
    <dbReference type="STRING" id="300267.SDY_4007"/>
    <dbReference type="EnsemblBacteria" id="ABB63925">
        <property type="protein sequence ID" value="ABB63925"/>
        <property type="gene ID" value="SDY_4007"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4007"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4719"/>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_6"/>
    <dbReference type="OMA" id="FRPGYAI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000016680" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG">
        <location>
            <begin position="1"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <sequence length="629" mass="69491" checksum="224E9F62C9751720" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AE3</accession>
    <name>FABR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional repressor FabR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabR</name>
        <name type="ordered locus">SDY_3765</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63712" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63712.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405203.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AE3"/>
    <dbReference type="SMR" id="Q32AE3"/>
    <dbReference type="STRING" id="300267.SDY_3765"/>
    <dbReference type="PRIDE" id="Q32AE3"/>
    <dbReference type="EnsemblBacteria" id="ABB63712">
        <property type="protein sequence ID" value="ABB63712"/>
        <property type="gene ID" value="SDY_3765"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3765"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4452"/>
    <dbReference type="HOGENOM" id="CLU_081861_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01190">
        <property type="entry name" value="HTH_type_FabR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023764">
        <property type="entry name" value="Tscrpt_reg_HTH_FabR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000293575" description="HTH-type transcriptional repressor FabR">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="215" mass="24404" checksum="ACA9739EA947E256" modified="2007-07-10" version="2">MGVRAQQKEKTRRSLVEAAFSQLSAERSFASLSLREVAREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRAFTEAQAEAMVTIVFSAGAEALDVGVEQRRQLEERLVLQLRMISKGAYYWYRREQEKTAIIPGNVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AJ2</accession>
    <name>Q32AJ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhfW</name>
        <name evidence="6" type="ordered locus">SDY_3701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphopentomutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000090626.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405154.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AJ2"/>
    <dbReference type="STRING" id="300267.SDY_3701"/>
    <dbReference type="EnsemblBacteria" id="ABB63663">
        <property type="protein sequence ID" value="ABB63663"/>
        <property type="gene ID" value="SDY_3701"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3701"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4391"/>
    <dbReference type="HOGENOM" id="CLU_053861_1_0_6"/>
    <dbReference type="OMA" id="HQEIMGT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043094">
        <property type="term" value="P:cellular metabolic compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16009">
        <property type="entry name" value="PPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010045">
        <property type="entry name" value="DeoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024052">
        <property type="entry name" value="Phosphopentomutase_DeoB_cap_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21110">
        <property type="entry name" value="PTHR21110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001491">
        <property type="entry name" value="Ppentomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="3"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="408" mass="44550" checksum="237D65B58882041F" modified="2005-12-06" version="1">MARFVVLVIDSFGVGAMKDVTLVRPQDAGANTCGHILSQLPHLQLPTLEKLGLINALGYAPGDMQPSDSATWGVAELQHEGGDTFMGHQEILGTRPLPPLRMPFRDVIYRVEQALVSAGWQVERRGDELQFLWVNQAVAIGDNLEADLGQVYNITANLSVISFDDAIKIGRIVRDQVQVGRVITFGGLLTDSQRILNAAESKEGRFIGINAPRSGAYDNGFQVVHMGYGVDEKVQVPQKLYEAGVPTVLVGKVADIVNNPYGVSWQNLVDSQRIMDITLDEFTTHQTAFICTNIQETDLAGHAEDVARYAERLQVVDRNLALLVEAMQPDDCLVVMADHGNDPTIGHSHHTREVVPVLVYQQGLAATQLGVRTTLSDVGATVCEFFRAPPPQNGRSFLSSLRFAGDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B66</accession>
    <name>Q32B66_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA topoisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yrdD</name>
        <name evidence="2" type="ordered locus">SDY_3460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001129726.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404930.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B66"/>
    <dbReference type="STRING" id="300267.SDY_3460"/>
    <dbReference type="EnsemblBacteria" id="ABB63439">
        <property type="protein sequence ID" value="ABB63439"/>
        <property type="gene ID" value="SDY_3460"/>
    </dbReference>
    <dbReference type="GeneID" id="67415324"/>
    <dbReference type="KEGG" id="sdy:SDY_3460"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4113"/>
    <dbReference type="HOGENOM" id="CLU_104661_0_0_6"/>
    <dbReference type="OMA" id="HYPECDY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-C4_Topoisom" evidence="1">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="zf-C4_Topoisom" evidence="1">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="zf-C4_Topoisom" evidence="1">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="zf-C4_Topoisom" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="180" mass="19873" checksum="E1277748AFDFF9F1" modified="2005-12-06" version="1">MAKSALFTVRNNESCPKCGAELVIRSGKHGPFLGCSQYPACDYVRPLKSSADGHIVKVLEGQVCPVCGANLVLRQGRFGMFIGCSNYPECEHTELIDKPDETAITCPQCRTGHLVQRRSRYGKTFHSCDRYPECQFAINFKPIAGECPECHYPLLIEKKTAQGVKHFCASKQCGKPVSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BD7</accession>
    <name>Q32BD7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yrbG</name>
        <name evidence="7" type="ordered locus">SDY_3377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000922888.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404859.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BD7"/>
    <dbReference type="STRING" id="300267.SDY_3377"/>
    <dbReference type="EnsemblBacteria" id="ABB63368">
        <property type="protein sequence ID" value="ABB63368"/>
        <property type="gene ID" value="SDY_3377"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3377"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4031"/>
    <dbReference type="HOGENOM" id="CLU_007948_0_2_6"/>
    <dbReference type="OMA" id="TRDYGVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00367">
        <property type="entry name" value="TIGR00367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="171"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="321" mass="34316" checksum="7940274EA5303B84" modified="2005-12-06" version="1">MLLATALLIVGLLLVVYSADRLVFAASILCRTFGIPPLIIGMTVVSIGTSLPEIIVSLAASLHEQRDLAVGTALGSNIINILLILGLAALVRPFTVHSDVLRRELPLMLLVSVVAGSVLYDGQLSRSDGIFLLFLAVLWLLFIVKLARQGTDSLTREQLAELPRDGGLPVAFLWLGIALIIMPVATRMVVDNATVLANYFAISELTMGLTAIAIGTSLPELATAIAGVRKGENDIAVGNIIGANIFNIVIVLGLPALITPGEIDPLAYSRDYSVMLLVSIIFALLCWRRSPQPCRGVGVLLTGGFIVWLAMLYWLSPILVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BE1</accession>
    <name>Q32BE1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yrbC</name>
        <name evidence="2" type="ordered locus">SDY_3373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000476484.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404855.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BE1"/>
    <dbReference type="STRING" id="300267.SDY_3373"/>
    <dbReference type="EnsemblBacteria" id="ABB63364">
        <property type="protein sequence ID" value="ABB63364"/>
        <property type="gene ID" value="SDY_3373"/>
    </dbReference>
    <dbReference type="GeneID" id="67415974"/>
    <dbReference type="KEGG" id="sdy:SDY_3373"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4027"/>
    <dbReference type="HOGENOM" id="CLU_094502_3_0_6"/>
    <dbReference type="OMA" id="ISKSIMT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008869">
        <property type="entry name" value="MlaC/ttg2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042245">
        <property type="entry name" value="Tgt2/MlaC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36573">
        <property type="entry name" value="PTHR36573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05494">
        <property type="entry name" value="MlaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004649">
        <property type="entry name" value="MlaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220737" evidence="1">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="211" mass="23949" checksum="A8422FDFB0830663" modified="2005-12-06" version="1">MFKRLMMVALLVIAPLSAATAADQTNPYKLMDEAAQKTFDRLKNEQPQIRANPDYLRTIVDQELLPYVQVKYAGALVLGQYYKSATPAQRDAYFAAFREYLKQAYGQALAMYHGQTYQIAPEQPLGDKTIVPIRVTIIDPNGRPPVRLDFQWRKNSQTGNWQAYDMIAEGVSMITTKQNEWGTLLRTKGIDGLTAQLKSISQQKITLEEKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BG3</accession>
    <name>RIMP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimP</name>
        <name type="ordered locus">SDY_3349</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BG3"/>
    <dbReference type="SMR" id="Q32BG3"/>
    <dbReference type="STRING" id="300267.SDY_3349"/>
    <dbReference type="EnsemblBacteria" id="ABB63342">
        <property type="protein sequence ID" value="ABB63342"/>
        <property type="gene ID" value="SDY_3349"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3349"/>
    <dbReference type="HOGENOM" id="CLU_070525_1_1_6"/>
    <dbReference type="OMA" id="YIHVSLY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000229277" description="Ribosome maturation factor RimP">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <sequence length="152" mass="16821" checksum="1F44620B08688AC9" modified="2005-12-06" version="1">MGLSTLEQKLTEMITAPVEALGFELVGIEFIRGRTSTLRIYIDSEDGINVDDCADVSHQVSAVLDVEDPITVAYNLEVSSPGLDRPLFTAEHYARFVGEEVTLVLRMAVQNRRKWQGVIKAVDGEMITVTVEGKDEVFALSNIQKANLVPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BP5</accession>
    <name>Q32BP5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ygjH</name>
        <name evidence="5" type="ordered locus">SDY_3258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000450585.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404751.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BP5"/>
    <dbReference type="STRING" id="300267.SDY_3258"/>
    <dbReference type="EnsemblBacteria" id="ABB63260">
        <property type="protein sequence ID" value="ABB63260"/>
        <property type="gene ID" value="SDY_3258"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3258"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3893"/>
    <dbReference type="HOGENOM" id="CLU_065946_3_2_6"/>
    <dbReference type="OMA" id="CDKPVLL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="110" mass="12277" checksum="F9A79762B2434755" modified="2005-12-06" version="1">METVAYADFARLEMCVGKIVEVKRHENADKLYIVQVDVGEKTLQTVTSLVPYYSEEELMGKTVVVLCNLQKAKMRGETSECMLLCAETDDGSESVLLTPERMMPAGVRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BU4</accession>
    <name>Q32BU4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative synthetase/amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygiC</name>
        <name evidence="2" type="ordered locus">SDY_3202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000442866.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404702.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BU4"/>
    <dbReference type="STRING" id="300267.SDY_3202"/>
    <dbReference type="EnsemblBacteria" id="ABB63211">
        <property type="protein sequence ID" value="ABB63211"/>
        <property type="gene ID" value="SDY_3202"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3202"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3827"/>
    <dbReference type="HOGENOM" id="CLU_059175_0_0_6"/>
    <dbReference type="OMA" id="QWNSLHE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSP_synth" evidence="1">
        <location>
            <begin position="12"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="386" mass="45025" checksum="53BF7C0AF31E4D29" modified="2005-12-06" version="1">MERVSITERPDWREKAHEYGFNFHTMYGEPYWCEDAYYKLTLAQVEKLEEVTAELHQMCLKVVEKVIASDELMTKFRIPKHTWSFVRQSWLTHQPSLYSRLDLAWDGTGEPKLLENNADTPTSLYEAAFFQWIWLEDQLNAGNLPEGSDQFNSLQEKLIDRFVELREQYGFQLLHLTCCRDTVEDRGTIQYLQDCATEAEIATEFLYIDDIGLGEKGQFTDLQDQVISNLFKLYPWEFMLREMFSTKLEDAGVRWLEPAWKSIISNKALLPLLWEMFPNHPNLLPAYFAEDNHPQMEKYVVKPIFSREGANVSIIENGKTIEAAEGPYGEEGMIVQQFHPLPKFGDSYMLIGSWLVNDQPAGIGIREDRALITQDMSRFYPHIFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BV8</accession>
    <name>Q32BV8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavodoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fldB</name>
        <name evidence="7" type="ordered locus">SDY_3187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Low-potential electron donor to a number of redox enzymes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flavodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001055874.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404688.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BV8"/>
    <dbReference type="SMR" id="Q32BV8"/>
    <dbReference type="STRING" id="300267.SDY_3187"/>
    <dbReference type="EnsemblBacteria" id="ABB63197">
        <property type="protein sequence ID" value="ABB63197"/>
        <property type="gene ID" value="SDY_3187"/>
    </dbReference>
    <dbReference type="GeneID" id="67415220"/>
    <dbReference type="KEGG" id="sdy:SDY_3187"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3809"/>
    <dbReference type="HOGENOM" id="CLU_051402_1_0_6"/>
    <dbReference type="OMA" id="ILGISTW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010086">
        <property type="entry name" value="Flavodoxin_lc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038996">
        <property type="entry name" value="FldA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01752">
        <property type="entry name" value="flav_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="6">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="173" mass="19700" checksum="89338715D106A68C" modified="2005-12-06" version="1">MNMGLFYGSSTCYTEMAAEKIRDIIGPELVTLHNLKDDSPKLMEQYDVLILGIPTWDFGEIQEDWEAVWDQLDDLNLEGKIVALYGLGDQLGYGEWFLDALGMLHDKLSTKGVKFVGYWPTEGYEFTSPKPVIADGQLFVGLALDETNQYDLSDERIQSWCEQILNEMAEHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BX3</accession>
    <name>Q32BX3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ygfA</name>
        <name evidence="5" type="ordered locus">SDY_3170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404673.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BX3"/>
    <dbReference type="STRING" id="300267.SDY_3170"/>
    <dbReference type="EnsemblBacteria" id="ABB63182">
        <property type="protein sequence ID" value="ABB63182"/>
        <property type="gene ID" value="SDY_3170"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3170"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3788"/>
    <dbReference type="HOGENOM" id="CLU_066245_0_0_6"/>
    <dbReference type="OMA" id="GIVFDFA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="126"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="182" mass="21156" checksum="F939A9F30AA0D32B" modified="2005-12-06" version="1">MIRQRRRTLTPEQQQEMGQQAATRMMTYPSVVMAHTVAVFLSFDGELDTQPLIEQLWRAGKRVYLPVLHPFSAGNLLFLNYHPQSELVMNRLKIHEPKLDVRDVLPLSRLDVLITPLVAFDEYGQRLGMGGGFYDRTLQNWQHYKMQPVGYAHDCQLVEKLPVEEWDIPLPAVVTPSKVWEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C01</accession>
    <name>Q32C01_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yggG</name>
        <name evidence="9" type="ordered locus">SDY_3140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000701840.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404645.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C01"/>
    <dbReference type="MEROPS" id="M48.022"/>
    <dbReference type="EnsemblBacteria" id="ABB63154">
        <property type="protein sequence ID" value="ABB63154"/>
        <property type="gene ID" value="SDY_3140"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3140"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3749"/>
    <dbReference type="HOGENOM" id="CLU_074068_0_0_6"/>
    <dbReference type="OMA" id="LNYKVYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="77"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="252" mass="26855" checksum="580330A63107E639" modified="2005-12-06" version="1">MKIRALLVAMSVATVLTGCQNMDSNGLLLSGAEAFQAYSLSDAQVKTLSDQACQEMDSKATIAPANSEYAKRLTTIANALGNNINGQPVNYKVYMAKDVNAFAMANGCIRVYSGLMDMMTDNEVEAVIGHEMGHVALGHVKKGMQVALGTNAVRVAAASAGGIVGSLSQSQLGDLGEKLVNSQFSQRQEAEADDYSYDLLRQRGISPAGLATSFEKLAKLEEGRQSSMFDDHPASAERAQHIRDRMSADGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C58</accession>
    <name>Q32C58_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Member of hyb operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hybE</name>
        <name evidence="2" type="ordered locus">SDY_3081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000134017.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404588.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C58"/>
    <dbReference type="STRING" id="300267.SDY_3081"/>
    <dbReference type="EnsemblBacteria" id="ABB63097">
        <property type="protein sequence ID" value="ABB63097"/>
        <property type="gene ID" value="SDY_3081"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3081"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3688"/>
    <dbReference type="HOGENOM" id="CLU_091699_2_0_6"/>
    <dbReference type="OMA" id="LTPWMIS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023994">
        <property type="entry name" value="NiFe-hyd_HybE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038530">
        <property type="entry name" value="NiFe-hyd_HybE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11939">
        <property type="entry name" value="NiFe-hyd_HybE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03993">
        <property type="entry name" value="hydrog_HybE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="162" mass="17964" checksum="CFDAEA3D42EEC016" modified="2005-12-06" version="1">MTEEIAGFQTSPKAQVQAAFEEIARRSMHDLSFLHPSMPVYVSDFTLFEGQWTGCVITPWMLSAVIFPGPDQLWPLRKVSEKIGLQLPYGTMTFTVGELDGVSQYLSCSLMSPLSHSMSIEEGQRLTDDCARMLLSLPVTNPDVPHAGRRALLFGRRSGENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C77</accession>
    <name>Q32C77_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yqhE</name>
        <name evidence="7" type="ordered locus">SDY_3061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C77"/>
    <dbReference type="STRING" id="300267.SDY_3061"/>
    <dbReference type="EnsemblBacteria" id="ABB63078">
        <property type="protein sequence ID" value="ABB63078"/>
        <property type="gene ID" value="SDY_3061"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3061"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_6"/>
    <dbReference type="OMA" id="AFKPGNE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0060">Ascorbate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="6">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="236" mass="26986" checksum="2229BB5766A55666" modified="2005-12-06" version="1">MGYRSIDTAAAYKNEEGVGKALKNASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVLAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPMMQQRQLHAWNATHKIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C80</accession>
    <name>Q32C80_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Low-affinity L-arabinose transport system proton symport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">araE</name>
        <name evidence="11" type="ordered locus">SDY_3058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404566.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C80"/>
    <dbReference type="STRING" id="300267.SDY_3058"/>
    <dbReference type="EnsemblBacteria" id="ABB63075">
        <property type="protein sequence ID" value="ABB63075"/>
        <property type="gene ID" value="SDY_3058"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3058"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3663"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_6"/>
    <dbReference type="OMA" id="WAITASF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="409" mass="44946" checksum="F10782CC33359713" modified="2005-12-06" version="1">MVSSMMLGAAIGALFNGWLSFRQGRKYSLMAGAILFVLGSIGSAFVTSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTSEKAREELNEIRESLKLKQGGWALFKINRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGYCLMQFDNGTASSGLFWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIGAAGTFWLYTALNIAFVGITFWLIPETKNVTLEHIERKLMAGEKLRNIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C81</accession>
    <name>Q32C81_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative resistance proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ygeA</name>
        <name evidence="3" type="ordered locus">SDY_3057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000848658.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404565.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C81"/>
    <dbReference type="STRING" id="300267.SDY_3057"/>
    <dbReference type="EnsemblBacteria" id="ABB63074">
        <property type="protein sequence ID" value="ABB63074"/>
        <property type="gene ID" value="SDY_3057"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3057"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3662"/>
    <dbReference type="HOGENOM" id="CLU_055360_1_0_6"/>
    <dbReference type="OMA" id="TNTMHLI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="PTHR21198:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="227" mass="25036" checksum="2DC6FD2EB4DA1A0A" modified="2005-12-06" version="1">MKTIGLLGGMSWESTIPYYRLINEGIKQRLGGLHSAQVLLHSVDFHEIEECQRRGEWDKTGDILAEAALGLQRAGAEGIVLCTNTMHKVADAIESRCTLPFLHIADATGRAITGAGMTRVALLGTRYTMEQDFYRGRLTEQFAINCLIPEADERAKINQIIFEELCLGQFTEASRAYYAQVIARLAEQGVIFGCTEIGLLVPEERSVLPVFDTAAIHAEDAVAFMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C89</accession>
    <name>Q32C89_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000895624.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404557.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C89"/>
    <dbReference type="STRING" id="300267.SDY_3049"/>
    <dbReference type="EnsemblBacteria" id="ABB63066">
        <property type="protein sequence ID" value="ABB63066"/>
        <property type="gene ID" value="SDY_3049"/>
    </dbReference>
    <dbReference type="GeneID" id="66673301"/>
    <dbReference type="KEGG" id="sdy:SDY_3049"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3654"/>
    <dbReference type="HOGENOM" id="CLU_064910_0_0_6"/>
    <dbReference type="OMA" id="IMFLDIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="26157" checksum="E5680AB2054A0D8D" modified="2005-12-06" version="1">MLFAWITDPNAWLALGTLTLLEIVLGIDNIIFLSLVVAKLPTAQRAHARRLGLAGAMVMRLALLASIAWVTRLTNPLFTIFSQEISARDLILLLGGLFLIWKASKEIHESIEGEEEGLKTRVSSFLGAIVQIMLLDIIFSLDSVITAVGLSDHLFIMMAAVVIAVGVMMFAARSIGDFVERHPSVKMLALSFLILVGFTLILESFDIHVPKGYIYFAMFFSIAVESLNLIRNKKNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C99</accession>
    <name>Q32C99_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RecBCD enzyme subunit RecC</fullName>
            <ecNumber evidence="6">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Exonuclease V subunit RecC</fullName>
            <shortName evidence="6">ExoV subunit RecC</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Helicase/nuclease RecBCD subunit RecC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">recC</name>
        <name evidence="8" type="ordered locus">SDY_3039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RecC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000946854.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404547.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C99"/>
    <dbReference type="STRING" id="300267.SDY_3039"/>
    <dbReference type="EnsemblBacteria" id="ABB63056">
        <property type="protein sequence ID" value="ABB63056"/>
        <property type="gene ID" value="SDY_3039"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3039"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3644"/>
    <dbReference type="HOGENOM" id="CLU_007513_0_0_6"/>
    <dbReference type="OMA" id="LMQLNLW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009338">
        <property type="term" value="C:exodeoxyribonuclease V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01486">
        <property type="entry name" value="RecC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006697">
        <property type="entry name" value="RecC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041500">
        <property type="entry name" value="RecC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17946">
        <property type="entry name" value="RecC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000980">
        <property type="entry name" value="RecC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01450">
        <property type="entry name" value="recC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecC_C" evidence="7">
        <location>
            <begin position="829"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1122" mass="128881" checksum="DD667350ED348EF7" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CF7</accession>
    <name>Q32CF7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000059303.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CF7"/>
    <dbReference type="STRING" id="300267.SDY_2974"/>
    <dbReference type="EnsemblBacteria" id="ABB62998">
        <property type="protein sequence ID" value="ABB62998"/>
        <property type="gene ID" value="SDY_2974"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2974"/>
    <dbReference type="HOGENOM" id="CLU_017779_2_3_6"/>
    <dbReference type="OMA" id="PRCHDEV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="47"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="457" mass="50649" checksum="A84ABEF24DDF8EC9" modified="2005-12-06" version="1">MSLSRAAIVDQLKEIVGADRVITDETVLKKNSIDRFRKFPDIHGIYTLPIPAAVVKLGSTEQVSRVLNFMNAHKINGVPRTGASATEGGLETVVENSVVLDGSAMNQIINIDIENMQATAQCGVPLEVLENALREKGYTTGHSPQSKPLAQMGGLVATRSIGQFSTLYGAIEDMVVGLEAVLADGTVTRIKNVPRRAAGPDIRHIIIGNEGALCYITEVTVKIFKFTPENNLFYGYILEDMKTGFNILREIMVEGYRPSIARLYDAEDGTQHFTHFADGKCVLIFMAEGNPRIAKATGEGIAEIVARYPQCQRVDSKLIETWFNNLNWGPDKVAAERVQILKTGNMGFTTEVSGCWSCIHEIYESVINRIRTEFPHADDITMLGGHSSHSYQNGTNMYFVYDYNVVNCKPEEEIDKYHNPLNKIICEETIRLGGSMVHHHGIGKHRVHWSKLEHGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CH5</accession>
    <name>Q32CH5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_2954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CH5"/>
    <dbReference type="STRING" id="300267.SDY_2954"/>
    <dbReference type="EnsemblBacteria" id="ABB62980">
        <property type="protein sequence ID" value="ABB62980"/>
        <property type="gene ID" value="SDY_2954"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2954"/>
    <dbReference type="HOGENOM" id="CLU_077904_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019851">
        <property type="entry name" value="CRISPR-assoc_Cas1_ECOLI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03638">
        <property type="entry name" value="cas1_ECOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="228" mass="24886" checksum="9EFD7299FB1CC09A" modified="2005-12-06" version="1">MGEAGVRVYASGQPGGARSDKLLYQAKLALDEDLRLKVVRKMFELRFGEPAPARRSVEQLRCIEGSRVRATYAFLAKKYGVTWNGRRYDPKDWEKGDTVNQCISAATSCLYGVTEAAILAAGYAPAIGFVHTGKPLSFVYDIADIIKFDTVVPKAFEIARRNPGEPDREVRLACRDIFRSSKTLAKLIPLIEDVLAAGEIQPPAPPEDAQPVAIPLPVSLGDAGHRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CT2</accession>
    <name>Q32CT2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha-ketoglutarate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kgtP</name>
        <name evidence="10" type="ordered locus">SDY_2830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000841103.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404364.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CT2"/>
    <dbReference type="SMR" id="Q32CT2"/>
    <dbReference type="STRING" id="300267.SDY_2830"/>
    <dbReference type="EnsemblBacteria" id="ABB62873">
        <property type="protein sequence ID" value="ABB62873"/>
        <property type="gene ID" value="SDY_2830"/>
    </dbReference>
    <dbReference type="GeneID" id="66673523"/>
    <dbReference type="KEGG" id="sdy:SDY_2830"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3407"/>
    <dbReference type="HOGENOM" id="CLU_001265_39_0_6"/>
    <dbReference type="OMA" id="THTNDPT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004736">
        <property type="entry name" value="MHS_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00883">
        <property type="entry name" value="2A0106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="23"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="432" mass="47052" checksum="264B8473195765DB" modified="2005-12-06" version="1">MAESTVTADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQHTMEDAALREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALKEAGSLKGLWRNRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKGKGMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D22</accession>
    <name>Q32D22_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAGC-like transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yphH</name>
        <name evidence="2" type="ordered locus">SDY_2740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404274.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D22"/>
    <dbReference type="STRING" id="300267.SDY_2740"/>
    <dbReference type="EnsemblBacteria" id="ABB62783">
        <property type="protein sequence ID" value="ABB62783"/>
        <property type="gene ID" value="SDY_2740"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2740"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3304"/>
    <dbReference type="HOGENOM" id="CLU_036604_13_5_6"/>
    <dbReference type="OMA" id="MGIGYLY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="399" mass="44928" checksum="EFC45E35948B2E35" modified="2005-12-06" version="1">MKMRACINNQQIRHHNKCVILELLYRQKRANKSTLARLAQISIPAVSNILQELESEKRVVNIDDESQTRGHSSGTWLIAPEGDWTLCLNVTPTSIECQVANACLSPKGEFEYLQIDAPTPQALLSEIEKCWHRHRKLWPDRTINLALAIHGQVNPVTGVSQTMPQAPWTTPVEVKYLLEEKLGIRVMVDNDCVMLALAEKWQNNSQKRDFCVINVDYGIGSSFVINEQIYRGSLYGSGQIGHTIVNPDGVVCDCGRYGCLETVASLSALKKQARVWLKSQPVSTQLDPEKLTTAQLIAAWQSGEPWITSWVYRSANAIGLSLYNFLNILNINQIWLYGRSCAFGEHWLNTIIRQTGFNPFDRDEGPSVKATQIGFGQLSRAQQVLGISYLYVETQLRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DD3</accession>
    <name>Q32DD3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Cysteine synthase</fullName>
            <ecNumber evidence="5 11">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysM</name>
        <name evidence="13" type="ordered locus">SDY_2617</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 11"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001358955.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404163.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DD3"/>
    <dbReference type="STRING" id="300267.SDY_2617"/>
    <dbReference type="EnsemblBacteria" id="ABB62672">
        <property type="protein sequence ID" value="ABB62672"/>
        <property type="gene ID" value="SDY_2617"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2617"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3154"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_6"/>
    <dbReference type="OMA" id="GIRRWPE"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005858">
        <property type="entry name" value="CysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314:SF100">
        <property type="entry name" value="PTHR10314:SF100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01138">
        <property type="entry name" value="cysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="5"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="174"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB62672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="303" mass="32576" checksum="04FDCC1EF895E324" modified="2005-12-06" version="1">MSTLEQTIGNTPLVKLQRMGPNNGSEVWLKLEGNNPAGSVKDRAALSMIVEAEKRGEIKPGDVLIEATSGNTGIALAMIAALKGYRMKLLMPDNMSQERRAAMRAYGAELILVTKEQGMEGARDLALEMADRGEGKLLDQFNNPDNPYAHYTTTGPEIWQQTGGRITHFVSSMGTTGTITGVSRFMREQSKPVTIVGLQPEEGSSIPGIRRWPAEYLPGIFNASLVDEVLDIHQRDAENTMRELAVREGIFCGVSSGGAVAGALRVAKANPGAVVVAIICDRGDRYLSTGVFGEEHFSQGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DG3</accession>
    <name>Q32DG3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404133.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DG3"/>
    <dbReference type="EnsemblBacteria" id="ABB62642">
        <property type="protein sequence ID" value="ABB62642"/>
        <property type="gene ID" value="SDY_2578"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2578"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3108"/>
    <dbReference type="HOGENOM" id="CLU_2571967_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="9643" checksum="559D4FDEF801A045" modified="2005-12-06" version="1">MTSRLFLRKNHNFKRGLKDKWCISNASLDNALLVSKFIEIIMLIKWVVIFLLAQINFLFLKQSSSFNVINKNVLKRWTDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DG7</accession>
    <name>Q32DG7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000867644.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404129.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DG7"/>
    <dbReference type="EnsemblBacteria" id="ABB62638">
        <property type="protein sequence ID" value="ABB62638"/>
        <property type="gene ID" value="SDY_2574"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2574"/>
    <dbReference type="HOGENOM" id="CLU_2422485_0_0_6"/>
    <dbReference type="OMA" id="TEKTSMM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221038" evidence="2">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="10091" checksum="9918E5709048939A" modified="2005-12-06" version="1">MKVNLIVFSLFLLVSIMACNVFAFSNSGGGSETSYKEPEKTSAMTTTHSTKFQPSQAILFKMREDAPPLNLTEETTPTYPTKASYLIHPVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DJ3</accession>
    <name>FADI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="1">2.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ACSs</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acetyl-CoA acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-ketothiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Fatty acid oxidation complex subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fadI</name>
        <name type="ordered locus">SDY_2543</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000531962.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404103.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DJ3"/>
    <dbReference type="SMR" id="Q32DJ3"/>
    <dbReference type="STRING" id="300267.SDY_2543"/>
    <dbReference type="EnsemblBacteria" id="ABB62612">
        <property type="protein sequence ID" value="ABB62612"/>
        <property type="gene ID" value="SDY_2543"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2543"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3061"/>
    <dbReference type="HOGENOM" id="CLU_031026_2_0_6"/>
    <dbReference type="OMA" id="MTAFPEP"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01618">
        <property type="entry name" value="FadI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012806">
        <property type="entry name" value="Ac-CoA_C-AcTrfase_FadI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02446">
        <property type="entry name" value="FadI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000069518" description="3-ketoacyl-CoA thiolase">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01618"/>
        </source>
    </evidence>
    <sequence length="436" mass="46451" checksum="2715E80FA0578107" modified="2005-12-06" version="1">MGQVLPLVTRQGDRIAIVSGLRTPFARQATAFHGIPAVDLGKMVVGELLARSEIPAEVIEQLVFGQVVQMPEAPNIAREIVLGTGMNVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKKLARVLVDVNKARTMSQRLKLFSRLRLRDLMPVPPAVAEYSTGLRMGDTAEQMAKTYGITREQQDALAHRSHQRAAQSWSEGKLKEEVMTAFIPPYKQLLAEDNNICGNSSLADYAKLRPAFDRKHGTVTAANSTPLTDGAAAVILMTESRTKELGLVPLGYLRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTMADLTLIDMHEAFAAQTLANIQLLGSERFACNVLGRAHATGEVDDSKFNVLGGSIAYGHPFAATGARIITQTLHELRRRGGGFGLVTACAAGGLGAAMVLEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DK5</accession>
    <name>Q32DK5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DK5"/>
    <dbReference type="STRING" id="300267.SDY_2531"/>
    <dbReference type="EnsemblBacteria" id="ABB62600">
        <property type="protein sequence ID" value="ABB62600"/>
        <property type="gene ID" value="SDY_2531"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2531"/>
    <dbReference type="HOGENOM" id="CLU_095265_0_0_6"/>
    <dbReference type="OMA" id="DEGAYCR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021407">
        <property type="entry name" value="DUF2544"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11245">
        <property type="entry name" value="DUF2544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="169" mass="18600" checksum="5E708AE52F4321B3" modified="2005-12-06" version="1">MGCDSLPVKFTVTGEVSGCPWLVTVRVISHSATVPPETYIGPQTPVSTCPAQSLTPYDISWDQNYVVKNKVIRLQSTGGMIEKTLPTFLMKDGKLCDGGQASDEGAYCRFVTQMLTFSSSGCDNGKVTVTPNRHPITDKEVHDMVVHVDTTERQPIDSTCRFTYVLNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DX4</accession>
    <name>Q32DX4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arginine 3rd transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">artM</name>
        <name evidence="11" type="ordered locus">SDY_2407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000464490.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403972.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DX4"/>
    <dbReference type="STRING" id="300267.SDY_2407"/>
    <dbReference type="EnsemblBacteria" id="ABB62481">
        <property type="protein sequence ID" value="ABB62481"/>
        <property type="gene ID" value="SDY_2407"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2407"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2904"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_4_6"/>
    <dbReference type="OMA" id="YYILPRQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="12"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="222" mass="24958" checksum="B841F4221C7A5EC8" modified="2005-12-06" version="1">MFEYLPELMKGLHTSLTLTVASLIVALILALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGPGQFPTLQEYPALWHLLSEPWLCALIALSLNSAAYTTQLFYGAIRAIPEGQWQSCSALGMSKKDTLAILLPYAFKRSLSSYSNEVVLVFKSTSLAYTITLMEVMGYSQLLYGRTYDVMVFGAAGIIYLIVNGLLTLMMRLIERKALTFERRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E48</accession>
    <name>Q32E48_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycbL</name>
        <name evidence="2" type="ordered locus">SDY_2330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001109448.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403898.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E48"/>
    <dbReference type="STRING" id="300267.SDY_2330"/>
    <dbReference type="EnsemblBacteria" id="ABB62407">
        <property type="protein sequence ID" value="ABB62407"/>
        <property type="gene ID" value="SDY_2330"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2330"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2813"/>
    <dbReference type="HOGENOM" id="CLU_030571_5_0_6"/>
    <dbReference type="OMA" id="GAWGTNC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="215" mass="23730" checksum="33E849259ED35630" modified="2005-12-06" version="1">MNYRIIPVTAFSQNCSLIWCEQTRLAALVDPGGDAEKIKQEVDASGLTLMQILLTHGHLDHVGAAAELAQHYGMPVFGPEKEDEFWLQGLPAQSRMFGLEECQPLTPDRWLNEGDTISIGNVALQVLHCPGHTPGHVVFFDDRAKLLISGDVIFKGGVGRSDFPRGDHNQLISSIKDKLLPLGDDVTFIPGHGPLSTLGYERLHNPFLQDEMPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E66</accession>
    <name>Q32E66_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_2312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000011095.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403880.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E66"/>
    <dbReference type="STRING" id="300267.SDY_2312"/>
    <dbReference type="EnsemblBacteria" id="ABB62389">
        <property type="protein sequence ID" value="ABB62389"/>
        <property type="gene ID" value="SDY_2312"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2312"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2790"/>
    <dbReference type="HOGENOM" id="CLU_095321_4_1_6"/>
    <dbReference type="OMA" id="WYKTAPH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="188" mass="20810" checksum="517981471550446A" modified="2005-12-06" version="1">MSFTNTPERYDVISAAFHWLSAIIFYGMFALGLWMVTLSYYDGWYHKAPELHKSIGILLMMGLVIRVLWRVISPPPGPLPSYSPMTRLAAKAGHLALYLLLFAIGISGYLISTADGKPISVFGWFDVPAPLADAGAQADFAGALHFWLAWSVVVLSVMHGFMALKHHFIDKDDTLKRMLGKSSSDYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EE4</accession>
    <name>Q32EE4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amino acid/amine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yeeF</name>
        <name evidence="6" type="ordered locus">SDY_2226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403802.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EE4"/>
    <dbReference type="STRING" id="300267.SDY_2226"/>
    <dbReference type="EnsemblBacteria" id="ABB62311">
        <property type="protein sequence ID" value="ABB62311"/>
        <property type="gene ID" value="SDY_2226"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2226"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2690"/>
    <dbReference type="HOGENOM" id="CLU_007946_6_0_6"/>
    <dbReference type="OMA" id="PDNWRIP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="454" mass="49770" checksum="E9185C0527043663" modified="2005-12-06" version="1">MTMSHNVTPNTSRVELRKTLTLVPVVMMGLAYMQPMTLFDTFGIVSGLTDGHVPTAYAFALIAILFTALSYGKLVRRYPSAGSAYTYAQKSISPTVGFMVGWSSLLDYLFAPMINILLAKIYFEALVPSIPSWMFVVALVAFMTAFNLRSLKSVANFNTVIVVLQVVLIAVILGMVVYGVFEGEGAGTLASTRPFWSGDAHVIPMITGATILCFSFTGFDGISNLSEETKDAERVIPRAIFLTALIGGMIFIFATYFLQLYFPDISRFKDPDASQPEIMLYVAGKAFQVGALIFSTITVLASGMAAHAGVARLMYVMGRDGVFPKSFFGYVHPKWRTPAMNIILVGAIALLAINFDLVMATALINFGALVAFTFVNLSVISQFWIREKRNKTLKDHFQYLFLPMCGALTVGALWVNLEESSMVLGLIWAAIGLIYLACVTKSFRNPVPQYEDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EI6</accession>
    <name>Q32EI6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yehE</name>
        <name evidence="2" type="ordered locus">SDY_2183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378787.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403760.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EI6"/>
    <dbReference type="STRING" id="300267.SDY_2183"/>
    <dbReference type="EnsemblBacteria" id="ABB62269">
        <property type="protein sequence ID" value="ABB62269"/>
        <property type="gene ID" value="SDY_2183"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2183"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2639"/>
    <dbReference type="HOGENOM" id="CLU_164781_0_0_6"/>
    <dbReference type="OMA" id="QRCGKNT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020386">
        <property type="entry name" value="Uncharacterised_YehE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10836">
        <property type="entry name" value="DUF2574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220807" evidence="1">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="9338" checksum="8A4AF62FD127DF52" modified="2005-12-06" version="1">MNKYWLSGIIFLAYGLASPAFSSETATLTINGRISPPTCSMAMVNNQPQQHCGQLTYNVDTRHQFSSPVKGVTTEVVVAGSDSNEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EQ6</accession>
    <name>Q32EQ6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yeiH</name>
        <name evidence="8" type="ordered locus">SDY_2108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000182057.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403690.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EQ6"/>
    <dbReference type="STRING" id="300267.SDY_2108"/>
    <dbReference type="EnsemblBacteria" id="ABB62199">
        <property type="protein sequence ID" value="ABB62199"/>
        <property type="gene ID" value="SDY_2108"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2108"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2538"/>
    <dbReference type="HOGENOM" id="CLU_033541_0_0_6"/>
    <dbReference type="OMA" id="FGLWCAI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004630">
        <property type="entry name" value="UPF0324_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00698">
        <property type="entry name" value="TIGR00698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="349" mass="36912" checksum="8AEDD3C7F8F0A704" modified="2005-12-06" version="1">MTNITLQKQHRTLWHFIPGLALSAVITGVALWGGSIPAVAGAGFSALTLAILLGMVLGNTIYPHIWKSCDGGVLFAKQYLLRLGIILYGFRLTFSQIADVGISGIIIDVLTLSSTFLLACFLGQKVFGLDKHTSWLIGAGSSICGAAAVLATEPVVKAEASKVTVAVATVVIFGTVAIFLYPAIYPLMSQWFSPETFGIYIGSTVHEVAQVVAAGHAISPDAENTAVISKMLRVMMLAPFLILLAARVKQLSGANSGEKSKITIPWFAILFIVVAIFNSFHLLPQSVVNMLVTLDTFLLAMAMAALGLTTHVSALKKAGAKPLLMALVLFAWLIVGGGAINYVIQSVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ES0</accession>
    <name>Q32ES0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ES0"/>
    <dbReference type="EnsemblBacteria" id="ABB62185">
        <property type="protein sequence ID" value="ABB62185"/>
        <property type="gene ID" value="SDY_2094"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2094"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8511" checksum="1FE5287B545DDB01" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITRILSTKFLHFLKIIAQYAKKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EV4</accession>
    <name>ACP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name type="ordered locus">SDY_2056</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000103754.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403642.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EV4"/>
    <dbReference type="SMR" id="Q32EV4"/>
    <dbReference type="STRING" id="300267.SDY_2056"/>
    <dbReference type="EnsemblBacteria" id="ABB62151">
        <property type="protein sequence ID" value="ABB62151"/>
        <property type="gene ID" value="SDY_2056"/>
    </dbReference>
    <dbReference type="GeneID" id="60373896"/>
    <dbReference type="GeneID" id="64337897"/>
    <dbReference type="GeneID" id="67515820"/>
    <dbReference type="KEGG" id="sdy:SDY_2056"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2471"/>
    <dbReference type="HOGENOM" id="CLU_108696_5_1_6"/>
    <dbReference type="OMA" id="CEIPDEQ"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="PRO" id="PR:Q32EV4"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000066690" description="Acyl carrier protein">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <sequence length="78" mass="8640" checksum="41FCFC39D45BFEA1" modified="2005-12-06" version="1">MSTIEERVKKIIGEQLGVKQEEVTNNASFVEDLGADSLDTVELVMALEEEFDTEIPDEEAEKITTVQAAIDYINGHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EW4</accession>
    <name>Q32EW4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycfL</name>
        <name evidence="2" type="ordered locus">SDY_2046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001225280.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403632.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EW4"/>
    <dbReference type="STRING" id="300267.SDY_2046"/>
    <dbReference type="EnsemblBacteria" id="ABB62141">
        <property type="protein sequence ID" value="ABB62141"/>
        <property type="gene ID" value="SDY_2046"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2046"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2460"/>
    <dbReference type="HOGENOM" id="CLU_145387_1_0_6"/>
    <dbReference type="OMA" id="TLHYRFY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09030">
        <property type="entry name" value="DUF1425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010824">
        <property type="entry name" value="DUF1425"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038483">
        <property type="entry name" value="YcfL-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07233">
        <property type="entry name" value="DUF1425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220687" evidence="1">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="13939" checksum="0C46282F9148BD49" modified="2005-12-06" version="1">MRKGCFGLVSLALLLLVGCRSHPEIPVNDEQSLVMESSLLAAGISAEKPVLSTSDIQPSASSTLYNERQEPVTVHYRFYWYDARGLEMHPLERPRSVTIPAHSAVTLYGSANFLGAHKVRFYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EY3</accession>
    <name>Q32EY3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Spermidine/putrescine transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potB</name>
        <name evidence="8" type="ordered locus">SDY_2027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403613.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EY3"/>
    <dbReference type="SMR" id="Q32EY3"/>
    <dbReference type="STRING" id="300267.SDY_2027"/>
    <dbReference type="EnsemblBacteria" id="ABB62122">
        <property type="protein sequence ID" value="ABB62122"/>
        <property type="gene ID" value="SDY_2027"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2027"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2440"/>
    <dbReference type="HOGENOM" id="CLU_016047_18_3_6"/>
    <dbReference type="OMA" id="RIYAWMI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="55"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="275" mass="31062" checksum="39D83EF14531D657" modified="2005-12-06" version="1">MIVTIVGWLVLFVFLPNLMIIGTSFLTRDDASFVKMVFTLDNYTRLLDPLYFEVLLHSLNMALIATLACLVLGYPFAWFLAKLPHKVRPLLLFLLIVPFWTNSLIRIYGLKIFLSTKGYLNEFLLWLGVIDTPIRIMFTPSAVIIGLVYILLPFMVMPLYSSIEKLDKPLLEAARDLGASKLQTFIRIIIPLTMPGIIAGCLLVMLPAMGLFYVSDLMGGAKNLLIGNVIKVQFLNIRDWPFGAATSITLTIVMGLMLLVYWRASRLLNKKVELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F40</accession>
    <name>Q32F40_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTS enzyme IID, mannose-specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">manZ</name>
        <name evidence="10" type="ordered locus">SDY_1965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403556.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F40"/>
    <dbReference type="SMR" id="Q32F40"/>
    <dbReference type="STRING" id="300267.SDY_1965"/>
    <dbReference type="EnsemblBacteria" id="ABB62065">
        <property type="protein sequence ID" value="ABB62065"/>
        <property type="gene ID" value="SDY_1965"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1965"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2373"/>
    <dbReference type="HOGENOM" id="CLU_060742_2_0_6"/>
    <dbReference type="OMA" id="TLLCMWL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004704">
        <property type="entry name" value="PTS_IID_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03613">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00828">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51108">
        <property type="entry name" value="PTS_EIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="286" mass="31303" checksum="F460050C589B44DF" modified="2005-12-06" version="1">MSEMVDTTQTTTEKKLTQSDIRGVFLRSNLFQGSWNFERMQALGFCFSMVPAIRRLYPENNEARKQAIRRHLEFFNTQPFVAAPILGVTLALEEQRANGAEIDDGAINGIKVGLMGPLAGVGDPIFWGTVRPVFAALGAGIAMSGSLLGPLLFFILFNLVRLATRYYGVAYGYSKGIDIVKDMGGGFLQKLTEGASILGLFVMGALVNKWTHVNIPLVVSRITDQTGKEHVTTVQTILDQLMPGLVPLLLTFACMWLLRKKVNPLWIIVGFFVIGIAGYACGLLGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FD6</accession>
    <name>SYY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="2">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tyrS</name>
        <name type="ordered locus">SDY_1860</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378747.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403460.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FD6"/>
    <dbReference type="SMR" id="Q32FD6"/>
    <dbReference type="STRING" id="300267.SDY_1860"/>
    <dbReference type="EnsemblBacteria" id="ABB61969">
        <property type="protein sequence ID" value="ABB61969"/>
        <property type="gene ID" value="SDY_1860"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1860"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2239"/>
    <dbReference type="HOGENOM" id="CLU_024003_0_3_6"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000234767" description="Tyrosine--tRNA ligase">
        <location>
            <begin position="2"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="2">
        <location>
            <begin position="357"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="235"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <sequence length="424" mass="47539" checksum="98ECD10D85B47FA2" modified="2007-01-23" version="3">MASSNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENSAIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFIEFSYNLLQGYDFACLNKQYGVVLQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDKNSGKAPRAQYVLAEQVTRLVHGEEGLQAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLMQALVDSELQPSRGQARKTIASNAITINGEKQSDPEYFFKEEDRLFGRFTLLRRGKKNYCLICWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FP7</accession>
    <name>Q32FP7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative collagenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydcP</name>
        <name evidence="2" type="ordered locus">SDY_1740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403349.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FP7"/>
    <dbReference type="STRING" id="300267.SDY_1740"/>
    <dbReference type="MEROPS" id="U32.003"/>
    <dbReference type="EnsemblBacteria" id="ABB61858">
        <property type="protein sequence ID" value="ABB61858"/>
        <property type="gene ID" value="SDY_1740"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1740"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2098"/>
    <dbReference type="HOGENOM" id="CLU_011540_5_0_6"/>
    <dbReference type="OMA" id="MKDNNQS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020988">
        <property type="entry name" value="Pept_U32_collagenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12392">
        <property type="entry name" value="DUF3656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3656" evidence="1">
        <location>
            <begin position="405"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="545" mass="60979" checksum="7FEE00CD2790AFC1" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FQ0</accession>
    <name>Q32FQ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FQ0"/>
    <dbReference type="EnsemblBacteria" id="ABB61855">
        <property type="protein sequence ID" value="ABB61855"/>
        <property type="gene ID" value="SDY_1737"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1737"/>
    <dbReference type="HOGENOM" id="CLU_2843221_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="65" mass="7452" checksum="37BFF514191AEE3A" modified="2005-12-06" version="1">MFQDCFTQWFFNLIAGVTRHDTAPPMKPEFQMVAAIRYIDALRFESTSELALFHIASLPLSISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FX3</accession>
    <name>Q32FX3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403273.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FX3"/>
    <dbReference type="STRING" id="300267.SDY_1661"/>
    <dbReference type="EnsemblBacteria" id="ABB61782">
        <property type="protein sequence ID" value="ABB61782"/>
        <property type="gene ID" value="SDY_1661"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1661"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2001"/>
    <dbReference type="HOGENOM" id="CLU_139190_0_0_6"/>
    <dbReference type="OMA" id="TDAQDGM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220704" description="Sulfatase domain-containing protein" evidence="4">
        <location>
            <begin position="30"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="58"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Ser)" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="161" mass="17115" checksum="676C4540FB57B7A8" modified="2005-12-06" version="1">MKSALKKSVVSTSISLILASGMAAFAAHAADDVKLKATKTNVASSDFTPTEYSTKGKPNIIVLTMDDLGYGQLPFDKGSFDPKTMENREVVDTYKIGIDKAIEAAQKSTPTLLSLMDEGVRFTNGYVAHGVSGPSRAAIMTGRAPARFGVYSNTDAQDGMR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G00</accession>
    <name>GLSA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaminase</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glsA</name>
        <name type="ordered locus">SDY_1631</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000257407.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403246.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G00"/>
    <dbReference type="SMR" id="Q32G00"/>
    <dbReference type="STRING" id="300267.SDY_1631"/>
    <dbReference type="EnsemblBacteria" id="ABB61755">
        <property type="protein sequence ID" value="ABB61755"/>
        <property type="gene ID" value="SDY_1631"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1631"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1964"/>
    <dbReference type="HOGENOM" id="CLU_027932_1_1_6"/>
    <dbReference type="OMA" id="RPRNPFI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000048365" description="Glutaminase">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <sequence length="308" mass="33498" checksum="DDC55B5DC61E6651" modified="2005-12-06" version="1">MAVAMDNAILENILRQVRPLIGQGKVADYIPALATVDGSRLGIAICTVDGQLFQAGDAQERFSIQSISKVLSLVVAMRHYSEEEIWQRVGKDPSGSPFNSLVQLEMEQGIPRNPFINAGALVVCDMLQGRLSAPRQRMLEVVRGLSGVSDISYDTVVARSEFEHSARNAAIAWLMKSFGNFHHDVTTVLQNYFHYCALKMSCVELARTFVFLANQGKAIHIDEPVVTPMQARQINALMATSGIYQNAGEFAWRVGLPAKSGVGGGIVAIVPHEMAIAVWSPELDDAGNSLAGIAVLEQLTKQLGRSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G04</accession>
    <name>Q32G04_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_1626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0187 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G04"/>
    <dbReference type="EnsemblBacteria" id="ABB61751">
        <property type="protein sequence ID" value="ABB61751"/>
        <property type="gene ID" value="SDY_1626"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1626"/>
    <dbReference type="HOGENOM" id="CLU_029790_4_2_6"/>
    <dbReference type="OMA" id="TDICGAC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="PTHR33281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="215" mass="24449" checksum="F5CC01CC4C3C364A" modified="2005-12-06" version="1">MIASRSLLREVKTTLPDSASVREFARLQIAFAHCLRMTLRKQPQAEVLAHYLKTEDLQRVLASNSPANRILLIMGEWLAVQRRNGQLSDILFISLNDRLNDISAVLAGCERIAYTPIPFAYTLILHRTVYLFCIMLPFALVVDLHYMTPFISVLISYTFISLDCLAEELEDPFGTENNDLPLDAICNAIEIDLLQMNDEAEIPAKILPDRHYQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G70</accession>
    <name>Q32G70_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000769322.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403176.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G70"/>
    <dbReference type="SMR" id="Q32G70"/>
    <dbReference type="STRING" id="300267.SDY_1549"/>
    <dbReference type="EnsemblBacteria" id="ABB61685">
        <property type="protein sequence ID" value="ABB61685"/>
        <property type="gene ID" value="SDY_1549"/>
    </dbReference>
    <dbReference type="GeneID" id="66674505"/>
    <dbReference type="KEGG" id="sdy:SDY_1549"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1858"/>
    <dbReference type="HOGENOM" id="CLU_876761_0_0_6"/>
    <dbReference type="OMA" id="AKFYHIT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025539">
        <property type="entry name" value="YdgH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036275">
        <property type="entry name" value="YdgH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010854">
        <property type="entry name" value="YdgH/BhsA/McbA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07338">
        <property type="entry name" value="DUF1471"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014774">
        <property type="entry name" value="YdgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159871">
        <property type="entry name" value="SSF159871"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220711" evidence="2">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1471" evidence="3">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1471" evidence="3">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1471" evidence="3">
        <location>
            <begin position="259"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="314" mass="33873" checksum="7906666FF0B58348" modified="2005-12-06" version="1">MKLKNTLLASALLSATAFSVNAATELTPEQAAAVKPFDRVVVTGRFNAIGEAVKAVSRRADKEGAASFYVVDTSDFGNSGNWRVVADLYKADAEKAEETSNRVINGVVELPKDQAVLIEPFDTVTVQGFYRSQPEVNDAITKAAKAKGAYSFYIVRQIDANQGGNQRITAFIYKKDAKKRIVQSPDVIPADSEAGRAALAAGGEAAKKVEIPGVATTASPSSEVGRFFETQSSKGGRYTVTLPDGTKVEELNKATAAMMVPFDSIKFSGNYGNMTEVSYQVAKRAAKKGAKYYHITRQWQERGNNLTVSADLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GC3</accession>
    <name>Q32GC3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ydjJ</name>
        <name evidence="9" type="ordered locus">SDY_1493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403123.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GC3"/>
    <dbReference type="STRING" id="300267.SDY_1493"/>
    <dbReference type="EnsemblBacteria" id="ABB61632">
        <property type="protein sequence ID" value="ABB61632"/>
        <property type="gene ID" value="SDY_1493"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1493"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1781"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_6"/>
    <dbReference type="OMA" id="QFGVADY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="7">
        <location>
            <begin position="167"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="335" mass="36584" checksum="598757D30D338226" modified="2005-12-06" version="1">MKIISAEIPVPKEDEVLIKVEYVGICGSDVHGFESGPFIPPKDPNQEIGLGHECAGTVVAVGSRVRKFKPGDRVNIEPGVPCGHCRYCLEGKYNICPDVDFMATQPNYRGALTHYLCHPESFTYKLPDNMDTMEGALVEPAAVGMHAAMLADVKPGKKIIILGAGCIGLMTLQACKCLGATEIAVVDVLEKRLAMAELLGATVVINGAKEDTIARCQQFTEDMGADIVFETAGSAVTVKQAPYLVMRGGKIMIVGTVPGDSAINFLKINREVTIQTVFRYANRYPVTIEAISSGRFDVKSMVTHIYDYRGNDSNLLIVFYVQIMPDDFVMQLHRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GE1</accession>
    <name>YDIB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Quinate/shikimate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD-dependent shikimate 5-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ydiB</name>
        <name type="ordered locus">SDY_1475</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-quinate + NAD(+) = 3-dehydroquinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29751"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.282"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-quinate + NADP(+) = 3-dehydroquinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29751"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.282"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.282"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + shikimate = 3-dehydroshikimate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:17741"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.282"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.282" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000798754.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403105.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GE1"/>
    <dbReference type="SMR" id="Q32GE1"/>
    <dbReference type="STRING" id="300267.SDY_1475"/>
    <dbReference type="EnsemblBacteria" id="ABB61614">
        <property type="protein sequence ID" value="ABB61614"/>
        <property type="gene ID" value="SDY_1475"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1475"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1759"/>
    <dbReference type="HOGENOM" id="CLU_044063_4_4_6"/>
    <dbReference type="OMA" id="SIFARND"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030266">
        <property type="term" value="F:quinate 3-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052733">
        <property type="term" value="F:quinate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052734">
        <property type="term" value="F:shikimate 3-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01578">
        <property type="entry name" value="Shikimate_DH_YdiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022872">
        <property type="entry name" value="Quinate/Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000280776" description="Quinate/shikimate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="164"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="241"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01578"/>
        </source>
    </evidence>
    <sequence length="297" mass="32390" checksum="88B8547CFBFE6D5B" modified="2005-12-06" version="1">MKNTCSTNWKHHPAKYELIGLMAYPIRHSLSPEMQNKALEKAGLPFTYMAFEVDNDSFPGAIEGLKALKMRGTGVSMPNKQLACEYVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIKGKTMVLLGAGGASTAIGAQGAIEGLKEIKLFNRRDEFFDKALAFAQRVNENTDCVVTVTDLADQQAFAEALASDDILTNGTKVGMKPLENKSLVNDISLLHPGLLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFTLWTGKDFPLEYVKQVMGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GG7</accession>
    <name>Q32GG7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GG7"/>
    <dbReference type="EnsemblBacteria" id="ABB61588">
        <property type="protein sequence ID" value="ABB61588"/>
        <property type="gene ID" value="SDY_1447"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1447"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7261" checksum="681A2D0E5BBF0C4D" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITSYFSDGGKNHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GG9</accession>
    <name>Q32GG9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1445</name>
        <name evidence="3" type="ordered locus">SDY_1451</name>
        <name evidence="4" type="ordered locus">SDY_1767</name>
        <name evidence="5" type="ordered locus">SDY_2989</name>
        <name evidence="6" type="ordered locus">SDY_4090</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61586">
        <property type="protein sequence ID" value="ABB61586"/>
        <property type="gene ID" value="SDY_1445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61592">
        <property type="protein sequence ID" value="ABB61592"/>
        <property type="gene ID" value="SDY_1451"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61882">
        <property type="protein sequence ID" value="ABB61882"/>
        <property type="gene ID" value="SDY_1767"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63012">
        <property type="protein sequence ID" value="ABB63012"/>
        <property type="gene ID" value="SDY_2989"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64006">
        <property type="protein sequence ID" value="ABB64006"/>
        <property type="gene ID" value="SDY_4090"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1445"/>
    <dbReference type="KEGG" id="sdy:SDY_1451"/>
    <dbReference type="KEGG" id="sdy:SDY_1767"/>
    <dbReference type="KEGG" id="sdy:SDY_2989"/>
    <dbReference type="KEGG" id="sdy:SDY_4090"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="IHRRHGL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27426" checksum="163C166F3B3754A5" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQSGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GI0</accession>
    <name>Q32GI0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polypeptide destructive to membrane potential</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">relF</name>
        <name evidence="3" type="ordered locus">SDY_1432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hok/gef family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000813254.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403066.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GI0"/>
    <dbReference type="SMR" id="Q32GI0"/>
    <dbReference type="STRING" id="300267.SDY_1432"/>
    <dbReference type="EnsemblBacteria" id="ABB61575">
        <property type="protein sequence ID" value="ABB61575"/>
        <property type="gene ID" value="SDY_1432"/>
    </dbReference>
    <dbReference type="GeneID" id="60668608"/>
    <dbReference type="GeneID" id="67415730"/>
    <dbReference type="KEGG" id="sdy:SDY_1432"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1706"/>
    <dbReference type="HOGENOM" id="CLU_177638_2_0_6"/>
    <dbReference type="OMA" id="CEVRIRS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000021">
        <property type="entry name" value="Hok/gef_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018084">
        <property type="entry name" value="Hok/gef_toxin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01848">
        <property type="entry name" value="HOK_GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00281">
        <property type="entry name" value="HOKGEFTOXIC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00556">
        <property type="entry name" value="HOK_GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU221113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="51" mass="5737" checksum="927EDBDE60B61A27" modified="2005-12-06" version="1">MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GI1</accession>
    <name>Q32GI1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403065.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GI1"/>
    <dbReference type="STRING" id="300267.SDY_1431"/>
    <dbReference type="EnsemblBacteria" id="ABB61574">
        <property type="protein sequence ID" value="ABB61574"/>
        <property type="gene ID" value="SDY_1431"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1431"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1705"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15392" checksum="120534E194A2FD55" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTRRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GL2</accession>
    <name>Q32GL2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative YcjX</fullName>
            <ecNumber evidence="1">2.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycjX</name>
        <name evidence="1" type="ordered locus">SDY_1399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000825812.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403034.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GL2"/>
    <dbReference type="STRING" id="300267.SDY_1399"/>
    <dbReference type="EnsemblBacteria" id="ABB61543">
        <property type="protein sequence ID" value="ABB61543"/>
        <property type="gene ID" value="SDY_1399"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1399"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1660"/>
    <dbReference type="HOGENOM" id="CLU_043657_0_0_6"/>
    <dbReference type="OMA" id="FDYPGEW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007413">
        <property type="entry name" value="DUF463_YcjX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38605">
        <property type="entry name" value="PTHR38605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04317">
        <property type="entry name" value="DUF463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019381">
        <property type="entry name" value="YcjX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="465" mass="52621" checksum="E7F2470D80C85318" modified="2005-12-06" version="1">MKRLKNELNALVNRGVDRHLRLAVTGLSRSGKTAFITAMVNQLLNIHVGARLPLLSAVREERLLGVKRIPQRDFGIPRFTYDEGLAQLYGDPPAWPTPTRGVSEIRLALRFKSNDSLLRHFKDTSTLYLEIVDYPGEWLLDLPMLAQDYLSWSRQMTGLLNGQRGEWSAKWQMMCEGLDPLAPADENRLADIAAAWTDYLHYCKQQGLHFIQPGRFVLPGDMAGAPALQFFPWPDVDAWGESKLAQADKHTNAGMLRERFNYYCEKVVKGFYKNHFLRFDRQIVLVDCLQPLNSGPQAFNDMRLALTQLMQSFHYGQRTLFRRLFSPVIDKLLFAATKADHVTIDQHANMVSLLQQLIQDAWQNAAFEGISMDCLGLASVQATTSGIIDVNGEKIPALRGNRLSDGAPLTVYPGEVPARLPGQAFWDKQGFQFEAFRPQVMDVDKPLPHIRLDAALEFLIGDKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GN1</accession>
    <name>Q32GN1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SapC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sapC</name>
        <name evidence="9" type="ordered locus">SDY_1379</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001146142.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403015.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GN1"/>
    <dbReference type="STRING" id="300267.SDY_1379"/>
    <dbReference type="EnsemblBacteria" id="ABB61524">
        <property type="protein sequence ID" value="ABB61524"/>
        <property type="gene ID" value="SDY_1379"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1379"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1636"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_6"/>
    <dbReference type="OMA" id="WFAVLPN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="99"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="296" mass="31529" checksum="193CFF85E594EB77" modified="2005-12-06" version="1">MPYDSVYSEKRPPGTLRTAWHKFYSDASAMVGLYGCAGLAVLCIFGGWFAPYGIDQQFLGYQLLPPSWSRYGEVSFFLGTDDLGRDVLSRLLSGAAPTVGGAFVVTLAATICGLVLGTFAGATHGLRSAVLNHILDTLLAIPSLLLAIIVVAFAGPSLSHAMFAVWLALLPRMVRSIYSMVHDELEKEYVIAARLDGASTLNILWFAVMPNITAGLVTEITRALSMAILDIAALGFLDLGAQLPSPEWGAMLGDALELIYVAPWTVMLPGAAIMISVLLVNLLGDGVRRAIIAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GR0</accession>
    <name>Q32GR0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000908596.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402986.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GR0"/>
    <dbReference type="EnsemblBacteria" id="ABB61495">
        <property type="protein sequence ID" value="ABB61495"/>
        <property type="gene ID" value="SDY_1348"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1348"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1597"/>
    <dbReference type="HOGENOM" id="CLU_209003_0_0_6"/>
    <dbReference type="OMA" id="FGVEMIR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="54" mass="6232" checksum="40A969682811711D" modified="2005-12-06" version="1">MLISDGDYMRLAMPSGNQEPRRDPELKRKAWLAVFLGSALFWVVVALLIWKVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GR6</accession>
    <name>Q32GR6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sohB</name>
        <name evidence="10" type="ordered locus">SDY_1342</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000422072.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402980.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GR6"/>
    <dbReference type="STRING" id="300267.SDY_1342"/>
    <dbReference type="EnsemblBacteria" id="ABB61489">
        <property type="protein sequence ID" value="ABB61489"/>
        <property type="gene ID" value="SDY_1342"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1342"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1591"/>
    <dbReference type="HOGENOM" id="CLU_070316_0_0_6"/>
    <dbReference type="OMA" id="FLYEYGL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013703">
        <property type="entry name" value="Peptidase_S49_N_proteobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08496">
        <property type="entry name" value="Peptidase_S49_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="8">
        <location>
            <begin position="158"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="346" mass="39185" checksum="80D419AC3CEF4E59" modified="2005-12-06" version="1">MELLSEYGLFLAKIVTVVLAIAAIIVNVAQRNKRQRGELRVNNLSEQYKEMKEELAEALMDSHQQKQWHKAQKKKHKQEAKAAKAKAKLGEVATDSKPRVWVLDFKGSMDAHEVNSLREEITAVLAAFKPQDQVVLRLESPGGMVHGYGLASSQLQRLRDKNIPLTVTVDKVAASGGYMMACVADKIVSAPFAIVGSIGVVAQMPNFNRFLKSKDIDIELHTAGQYKRTLTLLGENTEEGREKFREELNETHQLFKDFVKRMRPSLDIEQVATGEHWYGQQAVEKGLVDEINTSDEVILSLMEGREVVNVRYMQRKRLIDRFTGSAAESADRLLLRWWQRGQKPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GT3</accession>
    <name>Q32GT3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GT3"/>
    <dbReference type="EnsemblBacteria" id="ABB61472">
        <property type="protein sequence ID" value="ABB61472"/>
        <property type="gene ID" value="SDY_1325"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1325"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="115" mass="13389" checksum="754C582C32D4D9CC" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GV4</accession>
    <name>Q32GV4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oppD</name>
        <name evidence="6" type="ordered locus">SDY_1304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000538199.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402942.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GV4"/>
    <dbReference type="STRING" id="300267.SDY_1304"/>
    <dbReference type="EnsemblBacteria" id="ABB61451">
        <property type="protein sequence ID" value="ABB61451"/>
        <property type="gene ID" value="SDY_1304"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1304"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1550"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_6"/>
    <dbReference type="OMA" id="YEPAHPY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="337" mass="37135" checksum="381A515A25C736B0" modified="2005-12-06" version="1">MGVIETATVPLAQQQADALLNVKDLRVTFSTPDGDVTAVNDLNFSLRAGETLGIVGESGSGKSQTAFALMGLLAANGRIGGSATFNGREILNLPERELNKLRAEQISMIFQDPMTSLNPYMRVGEQLMEVLMLHKNMSKAEAFEESVRMLDAVKMPEARKRMKMYPHEFSGGMRQRVMIAMALLCRPKLLIADEPTTALDVTVQAQIMTLLNELKREFNTAIIMITHDLGVVAGICDKVLVMYAGRTMEYGNARDVFYQPVHPYSIGLLNAVPRLDAEGETMLTIPGNPPNLLRLPKGCPFQPRCPHAMEICSSAPPLEEFTPGRLRACFKPVEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GX2</accession>
    <name>Q32GX2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ychK</name>
        <name evidence="6" type="ordered locus">SDY_1286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GX2"/>
    <dbReference type="STRING" id="300267.SDY_1286"/>
    <dbReference type="EnsemblBacteria" id="ABB61433">
        <property type="protein sequence ID" value="ABB61433"/>
        <property type="gene ID" value="SDY_1286"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1286"/>
    <dbReference type="HOGENOM" id="CLU_047251_2_0_6"/>
    <dbReference type="OMA" id="MNNFPLE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2 3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="3">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="3">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="246" mass="26901" checksum="01D9A9D11EDA5A20" modified="2005-12-06" version="1">MRKIKIGLALGSGAARGWSHIGVINALKKVGIEIDIVAGCSIGSLVGAAYACDRLSALEDWVTSFSYWDVLRLMDLSWQRGGLLLGECVFNQYREIMPETEIENCSRRFAAVATNLSTGRELWFTEGDLHLAIRASCSIPGLMAPVAHNGYWLVDGAVVNPIPISLTRALGADIVIAVDLQHDAHLMQQDLLSFNVSEENSENGDSLPWHARLKEKVRQYNDTSGGDSTNGNRDYDHFYPGAGEPP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GZ7</accession>
    <name>HEM1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="1">GluTR</shortName>
            <ecNumber evidence="1">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemA</name>
        <name type="ordered locus">SDY_1259</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005023559.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402899.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GZ7"/>
    <dbReference type="SMR" id="Q32GZ7"/>
    <dbReference type="STRING" id="300267.SDY_1259"/>
    <dbReference type="EnsemblBacteria" id="ABB61408">
        <property type="protein sequence ID" value="ABB61408"/>
        <property type="gene ID" value="SDY_1259"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1259"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1496"/>
    <dbReference type="HOGENOM" id="CLU_035113_2_2_6"/>
    <dbReference type="OMA" id="FAFKCAA"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000004697" description="Glutamyl-tRNA reductase">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <sequence length="418" mass="46319" checksum="3083C423537E0295" modified="2005-12-06" version="1">MTLLALGINHKTAPVSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVEEQDNLQEALIRWLCDYHNLNEEDLRKSLYWHQDNDAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLARQIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALSDVDERLREADIIISSTASPLPIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSVDDLQSIISHNLAQRKAAAVEAETIVAQETSEFMAWLRAQSASETIREYRSQAEQVRDELTAKALAALEQGGDAQAIMQDLAWKLTNRLIHAPTKLLQQAARDGDNERLNILRDSLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H25</accession>
    <name>Q32H25_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H25"/>
    <dbReference type="EnsemblBacteria" id="ABB61380">
        <property type="protein sequence ID" value="ABB61380"/>
        <property type="gene ID" value="SDY_1229"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1229"/>
    <dbReference type="HOGENOM" id="CLU_2616709_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="95" mass="10692" checksum="C60E509FB1370F40" modified="2005-12-06" version="1">MHPVLQADETPLQILSTLKRVLRGLRQRGRLRGGICSGDVRLGPLMVDGDTGNAGLVILHLLQSEEVITLTFLSRCFEFISQSLQWFVIHNLTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H35</accession>
    <name>Q32H35_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H35"/>
    <dbReference type="EnsemblBacteria" id="ABB61370">
        <property type="protein sequence ID" value="ABB61370"/>
        <property type="gene ID" value="SDY_1217"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1217"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="7775" checksum="42631E582F17F5A3" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITQKRHGKKTLFEVPEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H71</accession>
    <name>CUTC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PF03932 family protein CutC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cutC</name>
        <name type="ordered locus">SDY_1178</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001185749.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402825.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H71"/>
    <dbReference type="SMR" id="Q32H71"/>
    <dbReference type="STRING" id="300267.SDY_1178"/>
    <dbReference type="EnsemblBacteria" id="ABB61334">
        <property type="protein sequence ID" value="ABB61334"/>
        <property type="gene ID" value="SDY_1178"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1178"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1392"/>
    <dbReference type="HOGENOM" id="CLU_050555_3_1_6"/>
    <dbReference type="OMA" id="FHRAFDQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000046941" description="PF03932 family protein CutC">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00795"/>
        </source>
    </evidence>
    <sequence length="248" mass="26617" checksum="B176F2DAE414D8A6" modified="2005-12-06" version="1">MALLEICCYSMECALTAQQNGADRVELCAAPKEGGLTPSLGVLKSVRQRVTIPVHPIIRPRGGDFCYSDGEFAAILEDVRTVRELGFPGLVTGVLDVDGNVDMSRMEKIMAAAGPLAVTFHRAFDMCANPLNTLNNLAELGITRVLTSGQKSDALQGLSKIMELIAHRDAPIIMAGAGVRAENLHHFLAAGVLEVHSSAGAWQASPMRYRNQGLSMSSDAHADEYSRYVVDGAAVAEMKGIIERHQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HF5</accession>
    <name>Q32HF5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yedD</name>
        <name evidence="2" type="ordered locus">SDY_1087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295642.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402741.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HF5"/>
    <dbReference type="STRING" id="300267.SDY_1087"/>
    <dbReference type="EnsemblBacteria" id="ABB61250">
        <property type="protein sequence ID" value="ABB61250"/>
        <property type="gene ID" value="SDY_1087"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1087"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1277"/>
    <dbReference type="HOGENOM" id="CLU_139754_0_0_6"/>
    <dbReference type="OMA" id="QRVDRPT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025596">
        <property type="entry name" value="YedD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038624">
        <property type="entry name" value="YedD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13987">
        <property type="entry name" value="YedD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221107" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="137" mass="15001" checksum="4C21CA40030D3231" modified="2005-12-06" version="1">MKKLAIAGALMLLAGCAEVENYNNVVKTPAPDWLAGYWQTKGPQRALVSPEAIGSLIVTKEGDTLDCRQWQRVIAVPGKLTLMSDDLTNVTVKRELYEVERDGNTIEYDGMTMERVDRPTAECAAALDKAPLPTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HI1</accession>
    <name>Q32HI1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HI1"/>
    <dbReference type="STRING" id="300267.SDY_1059"/>
    <dbReference type="EnsemblBacteria" id="ABB61224">
        <property type="protein sequence ID" value="ABB61224"/>
        <property type="gene ID" value="SDY_1059"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1059"/>
    <dbReference type="HOGENOM" id="CLU_089892_1_0_6"/>
    <dbReference type="OMA" id="CLARQTD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="241" mass="27349" checksum="42AD2554BE046C51" modified="2005-12-06" version="1">MKADNIKPAHVRLYMDKRGLKSKTQANHEKASMSRVFRWGYERGYVKGNPCQGVSKFSLKPRDYYFTDEEYIAIYQEASPVLQCAMEIAYLCATRIGDIRKLTWDQVMSKGLFIQQGKTGKKQLKQYSERLTFALEQAKSLGGQHFVVCNKYGGQYSYTGFNDIWRKARAAASEKLGYPITGTFHDLKAKGISDYDGSSKEKQLFSGHKTEAQVLTYDRKPAVTPTLDIPVLDVTVLSRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HQ5</accession>
    <name>Q32HQ5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ycdG</name>
        <name evidence="8" type="ordered locus">SDY_0981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402641.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HQ5"/>
    <dbReference type="STRING" id="300267.SDY_0981"/>
    <dbReference type="EnsemblBacteria" id="ABB61150">
        <property type="protein sequence ID" value="ABB61150"/>
        <property type="gene ID" value="SDY_0981"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0981"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1141"/>
    <dbReference type="HOGENOM" id="CLU_017959_1_1_6"/>
    <dbReference type="OMA" id="FGLCPKF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019918">
        <property type="entry name" value="Pyrimidine_permease_RutG_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03616">
        <property type="entry name" value="RutG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="464" mass="48012" checksum="39DBE18258A9B352" modified="2005-12-06" version="1">MVRSQLSRADAPCLLTSLRRQLMAMFGFPHWQLKSTSTESGVVAPDERLPFAQTAVMGVQHAVAMFGATVLMPILMGLDPNLSILMSGIGTLLFFFITGGRVPSYLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACGLVYTVIGLVVVKIGTRWIERLMPPVVTGAVVMAIGLNLAPIAVKSVSASGFDSWMAVMTVPCIGLVAVFTRGMIQRLLILVGLIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFSTPGFNGQAMMLIAPVAVILVAENLGHLKAVAGMTGRNMDPYMGRAFVGDGLATMLSGSVGGSGVTTYAENSGVMAVTKVYSTLVFVAAAIIAMLLGFSPKFGALIHTIPAAVIGGASIVVFGLIAVAGARMWVQNRVDLSQNGNLIMVAVTLVLGAGDFALTLGGFTLGGIGTATFGAILLNALLSRRLVDVPPPEVVHQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I07</accession>
    <name>Q32I07_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chaperone NapD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NapA signal peptide-binding chaperone NapD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">napD</name>
        <name evidence="5" type="ordered locus">SDY_0871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the cytoplasmic NapA precursor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NapD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000557376.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402539.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I07"/>
    <dbReference type="STRING" id="300267.SDY_0871"/>
    <dbReference type="EnsemblBacteria" id="ABB61048">
        <property type="protein sequence ID" value="ABB61048"/>
        <property type="gene ID" value="SDY_0871"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0871"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1006"/>
    <dbReference type="HOGENOM" id="CLU_155794_1_0_6"/>
    <dbReference type="OMA" id="ENQGFIT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051224">
        <property type="term" value="P:negative regulation of protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02200">
        <property type="entry name" value="NapD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005623">
        <property type="entry name" value="Chaperone_NapD_NO3_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38603">
        <property type="entry name" value="PTHR38603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03927">
        <property type="entry name" value="NapD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="9527" checksum="EE59DF4EF3AF650D" modified="2005-12-06" version="1">MHTNWQVCSLVVQAKSERISDISTQLNAFPGCEVAVSDAPSGQLIVVVEAEDSETLIQTIESVRNVEGVLAVSLVYHQQEEQDEETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I34</accession>
    <name>Q32I34_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dacC</name>
        <name evidence="17" type="ordered locus">SDY_0841</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378637.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402512.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I34"/>
    <dbReference type="STRING" id="300267.SDY_0841"/>
    <dbReference type="MEROPS" id="S11.003"/>
    <dbReference type="EnsemblBacteria" id="ABB61023">
        <property type="protein sequence ID" value="ABB61023"/>
        <property type="gene ID" value="SDY_0841"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0841"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.968"/>
    <dbReference type="HOGENOM" id="CLU_027070_8_1_6"/>
    <dbReference type="OMA" id="TNEAKYC"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221141" description="Serine-type D-Ala-D-Ala carboxypeptidase" evidence="15">
        <location>
            <begin position="28"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="PBP5_C" evidence="16">
        <location>
            <begin position="285"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB61023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="400" mass="43638" checksum="7E389E6F352DD240" modified="2005-12-06" version="1">MTQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWVTGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLAWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGKAGSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFGRMWDFVMMKFHQWFGSWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I78</accession>
    <name>Q32I78_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1471 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybiJ</name>
        <name evidence="4" type="ordered locus">SDY_0797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000849305.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402468.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I78"/>
    <dbReference type="STRING" id="300267.SDY_0797"/>
    <dbReference type="EnsemblBacteria" id="ABB60979">
        <property type="protein sequence ID" value="ABB60979"/>
        <property type="gene ID" value="SDY_0797"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0797"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.920"/>
    <dbReference type="HOGENOM" id="CLU_158602_2_2_6"/>
    <dbReference type="OMA" id="LMHATAV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036275">
        <property type="entry name" value="YdgH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010854">
        <property type="entry name" value="YdgH/BhsA/McbA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07338">
        <property type="entry name" value="DUF1471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159871">
        <property type="entry name" value="SSF159871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221116" description="DUF1471 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1471" evidence="3">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="8616" checksum="6039229B645F16ED" modified="2005-12-06" version="1">MKTINTVVAAMALSTLSFGVFAAEPVTASQAQNMNKIGVVSADGASTLYALEAKLAEKAAAAGASGYSITSATNNNKLSGTAVIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I92</accession>
    <name>Q32I92_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Outer membrane protein X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ompX</name>
        <name evidence="6" type="ordered locus">SDY_0781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295296.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402454.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I92"/>
    <dbReference type="SMR" id="Q32I92"/>
    <dbReference type="STRING" id="300267.SDY_0781"/>
    <dbReference type="EnsemblBacteria" id="ABB60965">
        <property type="protein sequence ID" value="ABB60965"/>
        <property type="gene ID" value="SDY_0781"/>
    </dbReference>
    <dbReference type="GeneID" id="66670913"/>
    <dbReference type="KEGG" id="sdy:SDY_0781"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.900"/>
    <dbReference type="HOGENOM" id="CLU_099385_1_0_6"/>
    <dbReference type="OMA" id="RFNDWAS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044384">
        <property type="term" value="C:host outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000758">
        <property type="entry name" value="Enterovir_OMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00316">
        <property type="entry name" value="ENTEROVIROMP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00694">
        <property type="entry name" value="ENT_VIR_OMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00695">
        <property type="entry name" value="ENT_VIR_OMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221119" description="Outer membrane protein X" evidence="4">
        <location>
            <begin position="24"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="5">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="171" mass="18603" checksum="77CE1245DAE81462" modified="2005-12-06" version="1">MKKIACLSALAAVLAFTAGTSVAATSTVTGGYAQSDAQGQMNKMGGFNLKYRYEEDNSPLGVIGSFTYTEKSRTASSGDYNKNQYYGITAGPAYRINDWASIYGVVGVGYGKFQTTEYPTYKHDTSDYGFSYGAGLQFNPMENVALDFSYEQSRIRSVDVGTWIAGVGYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IC0</accession>
    <name>Q32IC0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_0156</name>
        <name evidence="4" type="ordered locus">SDY_0753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401879.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402426.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60390">
        <property type="protein sequence ID" value="ABB60390"/>
        <property type="gene ID" value="SDY_0156"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60937">
        <property type="protein sequence ID" value="ABB60937"/>
        <property type="gene ID" value="SDY_0753"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0156"/>
    <dbReference type="KEGG" id="sdy:SDY_0753"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.178"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="15030" checksum="F075617D6C754B56" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIRHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ID6</accession>
    <name>Q32ID6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybjO</name>
        <name evidence="2" type="ordered locus">SDY_0737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000389260.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402410.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ID6"/>
    <dbReference type="STRING" id="300267.SDY_0737"/>
    <dbReference type="EnsemblBacteria" id="ABB60921">
        <property type="protein sequence ID" value="ABB60921"/>
        <property type="gene ID" value="SDY_0737"/>
    </dbReference>
    <dbReference type="GeneID" id="66670868"/>
    <dbReference type="KEGG" id="sdy:SDY_0737"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.851"/>
    <dbReference type="HOGENOM" id="CLU_142271_0_0_6"/>
    <dbReference type="OMA" id="TGYLWAA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019703">
        <property type="entry name" value="YbjO_DH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10767">
        <property type="entry name" value="DUF2593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="162" mass="18518" checksum="C618B11524CB0DCB" modified="2005-12-06" version="1">MEDETLGFFKKTSSSHARLNVPALVQVAALAIIMIRGLDVLMIFNTLGVRGIGEFIHRSVQTWSLTLVFLSSLVLVFIEIWCAFSLVKGRRWARWLYLLTQITAASYLWAASLGYGYPELFSIPGESKREIFHSLMLQKLPDMLILMLLFVPSTSRRFFQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IK6</accession>
    <name>Q32IK6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402340.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IK6"/>
    <dbReference type="EnsemblBacteria" id="ABB60851">
        <property type="protein sequence ID" value="ABB60851"/>
        <property type="gene ID" value="SDY_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0663"/>
    <dbReference type="HOGENOM" id="CLU_2493169_0_0_6"/>
    <dbReference type="OMA" id="SFASHYI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9343" checksum="B2E7D1C5B81A3619" modified="2005-12-06" version="1">MNALSGLQVITRRPDKRSASGVTKKCRKSLKTAPDTKTVFKGSFASHYVDKSSQVNPGTHITVRGSIHGEVSIKKMLKGSRCRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IS5</accession>
    <name>Q32IS5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402271.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IS5"/>
    <dbReference type="STRING" id="300267.SDY_0582"/>
    <dbReference type="EnsemblBacteria" id="ABB60782">
        <property type="protein sequence ID" value="ABB60782"/>
        <property type="gene ID" value="SDY_0582"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0582"/>
    <dbReference type="HOGENOM" id="CLU_2571965_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="9290" checksum="DA7F67DD1DA0A2AD" modified="2005-12-06" version="1">MRFSTIVSVVTLVWGISPRQPSGKNIIRWLLKKRTNGSVRYCQYTSHITSVQVAKFSVPLQLFISGEFDLRTFADRIDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IT8</accession>
    <name>Q32IT8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS911 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0467</name>
        <name evidence="3" type="ordered locus">SDY_0565</name>
        <name evidence="4" type="ordered locus">SDY_0720</name>
        <name evidence="5" type="ordered locus">SDY_0845</name>
        <name evidence="6" type="ordered locus">SDY_1030</name>
        <name evidence="7" type="ordered locus">SDY_1158</name>
        <name evidence="8" type="ordered locus">SDY_1932</name>
        <name evidence="9" type="ordered locus">SDY_1991</name>
        <name evidence="10" type="ordered locus">SDY_2845</name>
        <name evidence="11" type="ordered locus">SDY_3862</name>
        <name evidence="12" type="ordered locus">SDY_4292</name>
        <name evidence="13" type="ordered locus">SDY_4495</name>
    </gene>
    <organism evidence="3 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 14">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402164.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402258.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402393.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402515.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402686.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402806.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403529.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403581.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404375.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405295.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405681.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405862.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0467"/>
    <dbReference type="EnsemblBacteria" id="ABB60675">
        <property type="protein sequence ID" value="ABB60675"/>
        <property type="gene ID" value="SDY_0467"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60769">
        <property type="protein sequence ID" value="ABB60769"/>
        <property type="gene ID" value="SDY_0565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60904">
        <property type="protein sequence ID" value="ABB60904"/>
        <property type="gene ID" value="SDY_0720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61026">
        <property type="protein sequence ID" value="ABB61026"/>
        <property type="gene ID" value="SDY_0845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61195">
        <property type="protein sequence ID" value="ABB61195"/>
        <property type="gene ID" value="SDY_1030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61315">
        <property type="protein sequence ID" value="ABB61315"/>
        <property type="gene ID" value="SDY_1158"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62038">
        <property type="protein sequence ID" value="ABB62038"/>
        <property type="gene ID" value="SDY_1932"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62090">
        <property type="protein sequence ID" value="ABB62090"/>
        <property type="gene ID" value="SDY_1991"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62884">
        <property type="protein sequence ID" value="ABB62884"/>
        <property type="gene ID" value="SDY_2845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63804">
        <property type="protein sequence ID" value="ABB63804"/>
        <property type="gene ID" value="SDY_3862"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64190">
        <property type="protein sequence ID" value="ABB64190"/>
        <property type="gene ID" value="SDY_4292"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64371">
        <property type="protein sequence ID" value="ABB64371"/>
        <property type="gene ID" value="SDY_4495"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0467"/>
    <dbReference type="KEGG" id="sdy:SDY_0565"/>
    <dbReference type="KEGG" id="sdy:SDY_0720"/>
    <dbReference type="KEGG" id="sdy:SDY_0845"/>
    <dbReference type="KEGG" id="sdy:SDY_1030"/>
    <dbReference type="KEGG" id="sdy:SDY_1158"/>
    <dbReference type="KEGG" id="sdy:SDY_1932"/>
    <dbReference type="KEGG" id="sdy:SDY_1991"/>
    <dbReference type="KEGG" id="sdy:SDY_2845"/>
    <dbReference type="KEGG" id="sdy:SDY_3862"/>
    <dbReference type="KEGG" id="sdy:SDY_4292"/>
    <dbReference type="KEGG" id="sdy:SDY_4495"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1203"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_9_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB64190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB64371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11524" checksum="7EB16CCBB9D1CBCA" modified="2005-12-06" version="1">MKKRNFSAEFKRESAQLVVDQNYTVADAAKAMDVGLSTMTRWVKQLRDERQGKTPKASPITPEQIEIRELRKKLQRIEMENEILKKATALLMSDSLNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IX3</accession>
    <name>Q32IX3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">entA</name>
        <name evidence="1" type="ordered locus">SDY_0527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000347670.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402223.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IX3"/>
    <dbReference type="STRING" id="300267.SDY_0527"/>
    <dbReference type="EnsemblBacteria" id="ABB60734">
        <property type="protein sequence ID" value="ABB60734"/>
        <property type="gene ID" value="SDY_0527"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0527"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.620"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_6"/>
    <dbReference type="OMA" id="PYDDFPE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008667">
        <property type="term" value="F:2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05331">
        <property type="entry name" value="DH-DHB-DH_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003560">
        <property type="entry name" value="DHB_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01397">
        <property type="entry name" value="DHBDHDRGNASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04316">
        <property type="entry name" value="dhbA_paeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="248" mass="26249" checksum="3634CFCB4129F7D9" modified="2005-12-06" version="1">MDFSGKNVWVTGAGKGIGYATALAFVKAGAKVTGFDQAFTQEQYPFATEVMDVADAAQVAQVCQRLLAETERLDALVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGLELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVVDGGSTLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J16</accession>
    <name>Q32J16_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mbhA</name>
        <name evidence="4" type="ordered locus">SDY_0484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402180.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J16"/>
    <dbReference type="STRING" id="300267.SDY_0484"/>
    <dbReference type="EnsemblBacteria" id="ABB60691">
        <property type="protein sequence ID" value="ABB60691"/>
        <property type="gene ID" value="SDY_0484"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0484"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.571"/>
    <dbReference type="HOGENOM" id="CLU_016890_3_2_6"/>
    <dbReference type="OMA" id="FMVLWIM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="106"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="259" mass="28798" checksum="CCFBDB3AE41C34E3" modified="2005-12-06" version="1">MTLWIVNSVSKSERESIIAALHGQSIFNGGGLSPLNKISPSHPPKPATVAVPEETEKKSRDVNEKTALLKKKSATELGELATSINTIARDAHMEANLEMEIVPQGLRVLIKDDQNRNMFERGSAQIMPFFKTLLVELAPVFDSLDNKIIITGHTDAMAYKNNIYNNWNLSGDRALSARRVLEEAGMPEDKVMQVSAMADQMLLDAKNPQSAGNRRIEIMVLTKSASDTLYQYFGQHGDKVVQPLVQKLDKQQVLSQRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J45</accession>
    <name>Q32J45_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative alpha helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aefA</name>
        <name evidence="12" type="ordered locus">SDY_0454</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000177743.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402151.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J45"/>
    <dbReference type="STRING" id="300267.SDY_0454"/>
    <dbReference type="EnsemblBacteria" id="ABB60662">
        <property type="protein sequence ID" value="ABB60662"/>
        <property type="gene ID" value="SDY_0454"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0454"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.537"/>
    <dbReference type="HOGENOM" id="CLU_007829_3_0_6"/>
    <dbReference type="OMA" id="YWVWSDL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006686">
        <property type="entry name" value="MscS_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025692">
        <property type="entry name" value="MscS_IM_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024393">
        <property type="entry name" value="MscS_porin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12795">
        <property type="entry name" value="MscS_porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12794">
        <property type="entry name" value="MscS_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01246">
        <property type="entry name" value="UPF0003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220785" evidence="9">
        <location>
            <begin position="34"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="796"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="914"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="MscS_porin" evidence="11">
        <location>
            <begin position="50"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="MscS_TM" evidence="10">
        <location>
            <begin position="509"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB60662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1120" mass="127107" checksum="7BA648A60AD36D50" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JJ6</accession>
    <name>Q32JJ6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein HU-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hupB</name>
        <name evidence="4" type="ordered locus">SDY_0292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001043542.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402000.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JJ6"/>
    <dbReference type="SMR" id="Q32JJ6"/>
    <dbReference type="STRING" id="300267.SDY_0292"/>
    <dbReference type="EnsemblBacteria" id="ABB60511">
        <property type="protein sequence ID" value="ABB60511"/>
        <property type="gene ID" value="SDY_0292"/>
    </dbReference>
    <dbReference type="GeneID" id="67416485"/>
    <dbReference type="KEGG" id="sdy:SDY_0292"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.337"/>
    <dbReference type="HOGENOM" id="CLU_105066_3_2_6"/>
    <dbReference type="OMA" id="PAHEGIN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="9226" checksum="C56A3C766D53BB96" modified="2005-12-06" version="1">MNKSQLIDKIAAGADISKAAAGRALDAIIASVTESLKEGDDVALVGFGTFAVKERAARTGRNPQTGKEITIAAAKVPSFRAGKALKDAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JL4</accession>
    <name>Q32JL4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5 7" type="primary">purK</name>
        <name evidence="7" type="ordered locus">SDY_0274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000815558.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401982.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JL4"/>
    <dbReference type="STRING" id="300267.SDY_0274"/>
    <dbReference type="EnsemblBacteria" id="ABB60493">
        <property type="protein sequence ID" value="ABB60493"/>
        <property type="gene ID" value="SDY_0274"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0274"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.314"/>
    <dbReference type="HOGENOM" id="CLU_011534_0_0_6"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="125"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="355" mass="39430" checksum="34CA11C0EA867FBD" modified="2005-12-06" version="1">MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVPFQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADRLTQKQLFDKLHLPTAPWQLLAERSEWPAVFDRLGELAIVKRRTGGYDGRGQWCLRADETEQLPAECYGECIVEQGINFSGEVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANAQQQAQAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHNSGHWTQNGASISQFELHLRAITDLPLPQPVVNSPSVMINLIGSDVNYDWLKLPLVHLHWYDKEVRPGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVMWAQSKFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JQ8</accession>
    <name>METN_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine import ATP-binding protein MetN</fullName>
            <ecNumber evidence="1">7.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metN</name>
        <name type="ordered locus">SDY_0218</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine(out) = ADP + H(+) + L-methionine(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.4.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-methionine(out) + H2O = ADP + D-methionine(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29767"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57932"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.4.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000594003.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401938.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JQ8"/>
    <dbReference type="SMR" id="Q32JQ8"/>
    <dbReference type="STRING" id="300267.SDY_0218"/>
    <dbReference type="EnsemblBacteria" id="ABB60449">
        <property type="protein sequence ID" value="ABB60449"/>
        <property type="gene ID" value="SDY_0218"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0218"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.252"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_3_6"/>
    <dbReference type="OMA" id="VFITHEI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009276">
        <property type="term" value="C:Gram-negative-bacterium-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012692">
        <property type="entry name" value="ABC_MetN_proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02314">
        <property type="entry name" value="ABC_MetN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51264">
        <property type="entry name" value="METN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000270383" description="Methionine import ATP-binding protein MetN">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01719"/>
        </source>
    </evidence>
    <sequence length="343" mass="37820" checksum="C23E5CFC1D80EF31" modified="2005-12-06" version="1">MIKLSNITKVFHQGTRTIQALNNVSLHVPAGQIYGVIGASGAGKSTLIRCVNLLERPTEGSVLVDGQELTTLSESELTKARRQIGMIFQHFNLLSSRTVFGNVALPLELDNTPKDEIKRRVTELLSMVGLGDKHDSYPSNLSGGQKQRVAIARALASNPKVLLCDEATSALDPATTRSILELLKDINRRLGLTILLITHEMDVVKRICDCVAVISNGELIEQDTVSEVFSHPKTPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEVLGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K27</accession>
    <name>Q32K27_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiamine transport system permease protein ThiP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">yabK</name>
        <name evidence="14" type="ordered locus">SDY_0094</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000235616.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401819.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K27"/>
    <dbReference type="STRING" id="300267.SDY_0094"/>
    <dbReference type="EnsemblBacteria" id="ABB60330">
        <property type="protein sequence ID" value="ABB60330"/>
        <property type="gene ID" value="SDY_0094"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0094"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.110"/>
    <dbReference type="HOGENOM" id="CLU_021838_5_3_6"/>
    <dbReference type="OMA" id="PLYLFQL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005947">
        <property type="entry name" value="ThiP_ABC_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01253">
        <property type="entry name" value="thiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="56"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="331"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB60330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="536" mass="59467" checksum="9E64EB18F0A12519" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-05-15" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A4SH24</accession>
    <name>A4SH24_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">repA</name>
        <name evidence="2" type="ordered locus">SDY_PA01</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD197_spA</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD197_spA</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000640">
        <property type="protein sequence ID" value="ABO87495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001293214.1">
        <property type="nucleotide sequence ID" value="NC_009344.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001139944.1">
        <property type="nucleotide sequence ID" value="NC_009344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A4SH24"/>
    <dbReference type="EnsemblBacteria" id="ABO87495">
        <property type="protein sequence ID" value="ABO87495"/>
        <property type="gene ID" value="SDY_PA01"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_PA01"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5779"/>
    <dbReference type="HOGENOM" id="CLU_075770_0_0_6"/>
    <dbReference type="OMA" id="GEWARRC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD197_spA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000525">
        <property type="entry name" value="Initiator_Rep_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01051">
        <property type="entry name" value="Rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rep_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABO87495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="318" mass="37358" checksum="8B11534A94CB3E23" modified="2007-05-15" version="1">MSELVVFKANELAVSRYDLTEHETKLILFCVAKLNPTIENPTRDELTVKFSCSEYARTMGLSYENAWGRLNSATSDLFKRSVELIYPTGAVSKRIFNWTEYAEFNREEQTVTLVFSSYIQPLLFHLKKFIKYNLEHVKAFENKYSMRIYEWLLKELSQRKTHRGNIEISIKEFKFMLMLEKNYPLYAELNRWILKPVTNDLNTYSNMKLTIEKRGRPADTLIFQVELDKQIDLVTELAKDPASKKEDKTIRLTPENRLHEGLKTTLHDALTAKIQLTSFEAKFLSDMQSKYDLNGSFTWLTQKQRTTLEKILAKYGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q326R4</accession>
    <name>Q326R4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MxiM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mxiM</name>
        <name evidence="2" type="ordered locus">SDY_P181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378996.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406182.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326R4"/>
    <dbReference type="EnsemblBacteria" id="ABB64694">
        <property type="protein sequence ID" value="ABB64694"/>
        <property type="gene ID" value="SDY_P181"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P181"/>
    <dbReference type="HOGENOM" id="CLU_1814512_0_0_6"/>
    <dbReference type="OMA" id="GERQMIR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021546">
        <property type="entry name" value="MxiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038517">
        <property type="entry name" value="MxiM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11441">
        <property type="entry name" value="MxiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220903" evidence="1">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="142" mass="15887" checksum="31ADBF93F05191BC" modified="2005-12-06" version="1">MIRHGSNKLKIFILSILLLSLSGCALKASSNSEKEWHIVPVSKDYFSIPNDLFWSFNTTNKSINVYSKCISGKAVYSFNAGKFMSNFNVKEVDGCFMDAQKIAIDKLFSMLKDGVVLKGNKINDTILIEKDGEVKLKLIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q326X1</accession>
    <name>Q326X1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F pilin acetylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">traX</name>
        <name evidence="2" type="ordered locus">SDY_P124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000205723.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406125.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326X1"/>
    <dbReference type="EnsemblBacteria" id="ABB64637">
        <property type="protein sequence ID" value="ABB64637"/>
        <property type="gene ID" value="SDY_P124"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P124"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5679"/>
    <dbReference type="HOGENOM" id="CLU_069784_0_0_6"/>
    <dbReference type="OMA" id="ILMMALW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008875">
        <property type="entry name" value="TraX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014125">
        <property type="entry name" value="TraX_Ftype"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05857">
        <property type="entry name" value="TraX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02755">
        <property type="entry name" value="TraX_Ftype"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="248" mass="27314" checksum="922A51C00E402CEA" modified="2005-12-06" version="1">MTTDNTNTTRNDSLAARTDTWLQSFLVWSPGQRDIIKTVALVLMVLDHINLIFQLKQEWMFLAGRGAFPLFALVWGLNLSRHAHIRQPAINRLWGWGIIAQFAYYLAGFPWYEGNILFAFAVAAQVLTWCETRSGWRTAAAILLMALWGPLSGTSYGIAGLLMLAVSNRLYRAEDRAERLALVACLLAVIPALNLATSDAAAVAGLVMTVLTVGLVLCAGKSLPRFWPGDFFPTFYACHLAVLGVLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q327B5</accession>
    <name>Q327B5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406081.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327B5"/>
    <dbReference type="EnsemblBacteria" id="ABB64593">
        <property type="protein sequence ID" value="ABB64593"/>
        <property type="gene ID" value="SDY_P080"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P080"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5630"/>
    <dbReference type="HOGENOM" id="CLU_3103773_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="51" mass="5936" checksum="A130AA9600A0F57F" modified="2005-12-06" version="1">MLRAQLAQRMKTSGNKPNKRRRRCDEAADAEVLARILDIISDMPTYGYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q327R4</accession>
    <name>Q327R4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arm-DNA-bind_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405932.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327R4"/>
    <dbReference type="STRING" id="300267.SDY_4580"/>
    <dbReference type="EnsemblBacteria" id="ABB64441">
        <property type="protein sequence ID" value="ABB64441"/>
        <property type="gene ID" value="SDY_4580"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4580"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5420"/>
    <dbReference type="HOGENOM" id="CLU_027562_45_6_6"/>
    <dbReference type="OMA" id="SRFRYKI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arm-DNA-bind_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="117" mass="13237" checksum="DB5A81DE6476C450" modified="2005-12-06" version="1">MALTDIKVKTAKPKDKPYKLADGGGMYLLINTNGSKYWRMKYRFAGKEKMLSIGVYPDVTLADAREKRSEARKLLAAGGDPGEAKKEEKIAQQMSLKNTFEAIAREWHQSKADRWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q328A5</accession>
    <name>Q328A5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_4474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405841.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328A5"/>
    <dbReference type="EnsemblBacteria" id="ABB64350">
        <property type="protein sequence ID" value="ABB64350"/>
        <property type="gene ID" value="SDY_4474"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4474"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5281"/>
    <dbReference type="HOGENOM" id="CLU_036805_2_1_6"/>
    <dbReference type="OMA" id="RDRENIF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="236" mass="26414" checksum="55144DFE74089DD6" modified="2005-12-06" version="1">MDEKKLKALAAELVKGLKTEADLNQFSRMLTKLTVETVLNAELTDHLGHEKNAPKSGSNTRNGYSLKTVLYDDGEIELNTPRDRENIFEPQLIKKHQTRITQMDSQILSLYAKGMTTREIVATFKEMYDADVSPTLISKVADAVKEQVSEWQNRPLDALYPIVYLDCIVVKVRHGGSVINKAVFLALGINTDGQKELLGMWLAENEGAKFWLGVLSGLKNRPHPLTVKHRGVDTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q328N9</accession>
    <name>Q328N9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Methionine synthase</fullName>
            <ecNumber evidence="6 20">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 20">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">metH</name>
        <name evidence="30" type="ordered locus">SDY_4322</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20 22">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="20">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6 20"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000095944.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405707.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328N9"/>
    <dbReference type="STRING" id="300267.SDY_4322"/>
    <dbReference type="EnsemblBacteria" id="ABB64216">
        <property type="protein sequence ID" value="ABB64216"/>
        <property type="gene ID" value="SDY_4322"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4322"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5101"/>
    <dbReference type="HOGENOM" id="CLU_004914_2_0_6"/>
    <dbReference type="OMA" id="ADCIAMS"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 20 22" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="17 20 21" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 20 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 20 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 20 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="15 20 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="25">
        <location>
            <begin position="5"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="26">
        <location>
            <begin position="356"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="29">
        <location>
            <begin position="650"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="28">
        <location>
            <begin position="746"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="27">
        <location>
            <begin position="897"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="22">
        <location>
            <begin position="756"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="22">
        <location>
            <begin position="1189"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="804"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="808"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="860"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="946"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="ABB64216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1232" mass="136502" checksum="956C0DFD196C270E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q328U8</accession>
    <name>Q328U8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Anaerobic ribonucleoside-triphosphate reductase-activating protein</fullName>
            <ecNumber evidence="12">1.97.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nrdG</name>
        <name evidence="13" type="ordered locus">SDY_4256</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001106233.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405648.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328U8"/>
    <dbReference type="SMR" id="Q328U8"/>
    <dbReference type="STRING" id="300267.SDY_4256"/>
    <dbReference type="EnsemblBacteria" id="ABB64157">
        <property type="protein sequence ID" value="ABB64157"/>
        <property type="gene ID" value="SDY_4256"/>
    </dbReference>
    <dbReference type="GeneID" id="67414860"/>
    <dbReference type="KEGG" id="sdy:SDY_4256"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5017"/>
    <dbReference type="HOGENOM" id="CLU_089926_2_1_6"/>
    <dbReference type="OMA" id="NQVIHYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000368">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02491">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB64157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="154" mass="17446" checksum="3BB3E9FACC782FD5" modified="2005-12-06" version="1">MNYHQYYPVDIVNGPGTRCTLFVSGCVHECPGCYNKSTWRVNSGQPFTKAMEDQIINDLNDTRIKRQGISLSGGDPLHPQNVPDILKLVQRIRAECPGKDIWVWTGYKLDELNAAQMQVVDLINVLVDGKFVQDLKDPSLIWRGSSNQVVHHLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q328V2</accession>
    <name>YJGA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0307 protein YjgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjgA</name>
        <name type="ordered locus">SDY_4252</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0307 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000166263.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405644.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328V2"/>
    <dbReference type="SMR" id="Q328V2"/>
    <dbReference type="STRING" id="300267.SDY_4252"/>
    <dbReference type="EnsemblBacteria" id="ABB64153">
        <property type="protein sequence ID" value="ABB64153"/>
        <property type="gene ID" value="SDY_4252"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4252"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5013"/>
    <dbReference type="HOGENOM" id="CLU_106757_2_0_6"/>
    <dbReference type="OMA" id="NLWPNAD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16331">
        <property type="entry name" value="YjgA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00765">
        <property type="entry name" value="UPF0307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023153">
        <property type="entry name" value="PSPTO4464-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006839">
        <property type="entry name" value="Ribosome-assoc_YjgA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38101">
        <property type="entry name" value="PTHR38101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04751">
        <property type="entry name" value="DUF615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016183">
        <property type="entry name" value="UCP016183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158710">
        <property type="entry name" value="SSF158710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000257641" description="UPF0307 protein YjgA">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00765"/>
        </source>
    </evidence>
    <sequence length="181" mass="21101" checksum="F4C914378B4B968E" modified="2005-12-06" version="1">MTKQPEDWLDDVPGDDIEDDEIIWVSKSEIKRDTEELKRLGAEIVDLGKNALDKIPLDADLRAAIELAQRIKMEGRRRQLQLIGKMLRQRDVEPIRQALDKLKNRHNQQVVLFHKLENLRDRLIAQGDDAIAEVLNLWPDADRQQLRTLIRNAKKEKEGNKPPKSARQIFQYLRELAENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q329J3</accession>
    <name>Q329J3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amino acid/amine transport protein, cryptic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yjdE</name>
        <name evidence="6" type="ordered locus">SDY_4098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000093167.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405503.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329J3"/>
    <dbReference type="STRING" id="300267.SDY_4098"/>
    <dbReference type="EnsemblBacteria" id="ABB64012">
        <property type="protein sequence ID" value="ABB64012"/>
        <property type="gene ID" value="SDY_4098"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4098"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4821"/>
    <dbReference type="HOGENOM" id="CLU_007946_1_0_6"/>
    <dbReference type="OMA" id="YDGWILI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="445" mass="46873" checksum="78F20CA584CF767F" modified="2005-12-06" version="1">MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVYAKMSFLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIPIVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYVLSTTAIMGMIPNTALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKAGTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWAVVGSGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDAPISKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q329J8</accession>
    <name>Q329J8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">melA</name>
        <name evidence="8" type="ordered locus">SDY_4092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000986598.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405498.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329J8"/>
    <dbReference type="STRING" id="300267.SDY_4092"/>
    <dbReference type="CAZy" id="GH4">
        <property type="family name" value="Glycoside Hydrolase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64007">
        <property type="protein sequence ID" value="ABB64007"/>
        <property type="gene ID" value="SDY_4092"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4092"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4813"/>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_6"/>
    <dbReference type="OMA" id="EHIYHAA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="198"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="451" mass="50659" checksum="2FDF55AE15F50725" modified="2005-12-06" version="1">MMSAPKITFIGAGSTIFVKNILGDVFHREALKTAHIALMDIDPTRLEESHIVVRKLMDSAGASGKITCHTQQKEALEDADFVVVAFQIGGYEPCTVTDFEVCKRHGLEQTIADTLGPGGIMRALRTIPHLWQICEDMMEVCPDATMLNYVNPMAMNTWAMYARYPHIKQVGLCHSVQGTAEELARDLNIDPATLRYRCAGINHMAFYLELERKTADGSYVNLYPELLAAYDAGQAPKPNIHGNTRCQNIVRYEMFKKLGYFVTESSEHFAEYTPWFIKPGREDLIERYKVPLDEYPKRCVEQLANWHKELEEYKNASRIDIKPSREYASTIMNAIWTGEPSVIYGNVRNDGLIDNLPQGCCVEVACLVDANGIQPTKVGTLPSHLAALMQTNINVQTLLTEAILTENRDRVYHAAMMDPHTAAVLGIDEIYALVDDLIAAHGDWLPGWLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q329K3</accession>
    <name>Q329K3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sodium/glutamate symporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">gltS</name>
        <name evidence="2" type="ordered locus">SDY_4085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the sodium-dependent transport of glutamate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000468833.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405493.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329K3"/>
    <dbReference type="STRING" id="300267.SDY_4085"/>
    <dbReference type="EnsemblBacteria" id="ABB64002">
        <property type="protein sequence ID" value="ABB64002"/>
        <property type="gene ID" value="SDY_4085"/>
    </dbReference>
    <dbReference type="GeneID" id="58389951"/>
    <dbReference type="KEGG" id="sdy:SDY_4085"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4806"/>
    <dbReference type="HOGENOM" id="CLU_040907_0_0_6"/>
    <dbReference type="OMA" id="PTAMVNM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015813">
        <property type="term" value="P:L-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02062">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004445">
        <property type="entry name" value="GltS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36178">
        <property type="entry name" value="PTHR36178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03616">
        <property type="entry name" value="Glt_symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00210">
        <property type="entry name" value="gltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0915">Sodium</keyword>
    <keyword evidence="1" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1" id="KW-0769">Symport</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="401" mass="42425" checksum="9569AE0AF75634EC" modified="2005-12-06" version="1">MFHLDTLATLVAATLTLLLGRKLVHSVSFLKKYTIPEPVAGGLLVALALLVLKKSMGWEVNFDMSLRDPLMLAFFATIGLNANIASLRAGGRVVGIFLIVVVGLLVMQNAIGIGMASLLGLDPLMGLLAGSITLSGGHGTGAAWSKLFIERYGFTNATEVAMACATFGLVLGGLIGGPVARYLVKHSTTPNGIPDDQEVPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLLAGTAFELPTFVCVLFVGVILSNGLSIMGFYRVFERAVSVLGNVSLSLFLAMALMGLKLWELASLALPMLAILVVQTIFMALYAIFVTWRMMGKNYDAAVLAAGHCGFGLGATPTAIANMQAITERFGPSHMAFLVVPMVGAFFIDIVNALVIKLYLMLPIFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q329T9</accession>
    <name>Q329T9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">rbsK</name>
        <name evidence="13" type="ordered locus">SDY_3995</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378919.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405407.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329T9"/>
    <dbReference type="STRING" id="300267.SDY_3995"/>
    <dbReference type="EnsemblBacteria" id="ABB63916">
        <property type="protein sequence ID" value="ABB63916"/>
        <property type="gene ID" value="SDY_3995"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3995"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4703"/>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_6"/>
    <dbReference type="OMA" id="IPWRDEL"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="12">
        <location>
            <begin position="6"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="223"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="309" mass="32307" checksum="F1E2DDB55107BD66" modified="2005-12-06" version="1">MQNAGSLVVLGSINADHILNLQSFPTPGETVTGNHYQVAFGGKGANQAVAAGRSGANIAFIACTGDDSIGESVRQQLATDNIDITPVSVIKGESTGVALIFVNGEGENVIGIHAGANAALSPALVEAQRERIANASALLMQLESPLESVMAAAKIAHQNKTIVALNPALARELPDELLALVNIITPNETEAEKLTGIRVENDEDAAKAAQVLHEKGIRTVLITLGSRGVWASVNGEGQRVPGFRVQAVDTIAAGDTFNGALITALLEEKPLPEAIRFAHAAAAIAVTRKGAQPSVPWREENDAFLDRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AC3</accession>
    <name>Q32AC3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable pyruvate formate lyase activating enzyme 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pflC</name>
        <name evidence="11" type="ordered locus">SDY_3787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000204153.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405223.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AC3"/>
    <dbReference type="STRING" id="300267.SDY_3787"/>
    <dbReference type="EnsemblBacteria" id="ABB63732">
        <property type="protein sequence ID" value="ABB63732"/>
        <property type="gene ID" value="SDY_3787"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3787"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4476"/>
    <dbReference type="HOGENOM" id="CLU_058969_0_0_6"/>
    <dbReference type="OMA" id="HRCPWCA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040074">
        <property type="entry name" value="BssD/PflA/YjjW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01118">
        <property type="entry name" value="activating_enzymes__group_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="33"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="292" mass="32523" checksum="F7EB70B53153B8F8" modified="2005-12-06" version="1">MTSSAGQRISCNVVETRRNDVARIFNIQRYSLNDGEGIRTVVFFKGCPHLCPWCANPESISGKIQTVRREAKCLHCAKCLRDADECPSGAFERIGRDISLDALEREVMKDDIFFRTSGGGVTLSGGEVLMQAEFATRFLQRLRLWGVSCAIETAGDAPVSKLLPLAKLCDEVLFDLKIMDATQARDVVKMNLPRVMENLRLLVSEGVNVIPRLPLIPGFTLSRENMQQALDVLIPLKIRQIHLLPFHQYGEPKYRLLGKTWSMKEVPAPSSADVATMREMAERAGFQVTVGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AH1</accession>
    <name>NFI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease V</fullName>
            <ecNumber evidence="1">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyribonuclease V</fullName>
            <shortName evidence="1">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfi</name>
        <name type="ordered locus">SDY_3728</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endonuclease V family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000362382.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405175.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AH1"/>
    <dbReference type="SMR" id="Q32AH1"/>
    <dbReference type="STRING" id="300267.SDY_3728"/>
    <dbReference type="EnsemblBacteria" id="ABB63684">
        <property type="protein sequence ID" value="ABB63684"/>
        <property type="gene ID" value="SDY_3728"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3728"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4420"/>
    <dbReference type="HOGENOM" id="CLU_047631_1_0_6"/>
    <dbReference type="OMA" id="RIHFRQA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000047001" description="Endonuclease V">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <sequence length="223" mass="24614" checksum="AA19237F3145D954" modified="2005-12-06" version="1">MDLASLRAQQIELASSVIREDRLDKDPPDLIAGADVGFEQGGEVTRAAMVLLKYPSLELVEYKVARIATTMPYIPGFLSFREYPALLAAWEMLSQKPDLVFVDGHGISHPRRLGVASHFGLLVDVPTIGVAKKRLCGKFEPLPSEPGALAPLMDKGEQLAWVWRSKARCNPLFIATGHRVSVDSALAWVQRCMKGYRLPEPTRWADAVASERPAFVSYTANQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AJ6</accession>
    <name>Q32AJ6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpS</name>
        <name evidence="10" type="ordered locus">SDY_3695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000165543.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405150.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AJ6"/>
    <dbReference type="SMR" id="Q32AJ6"/>
    <dbReference type="STRING" id="300267.SDY_3695"/>
    <dbReference type="EnsemblBacteria" id="ABB63659">
        <property type="protein sequence ID" value="ABB63659"/>
        <property type="gene ID" value="SDY_3695"/>
    </dbReference>
    <dbReference type="GeneID" id="60902159"/>
    <dbReference type="KEGG" id="sdy:SDY_3695"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4383"/>
    <dbReference type="HOGENOM" id="CLU_029244_1_1_6"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="334" mass="37424" checksum="DEB972FAFDAF3E28" modified="2005-12-06" version="1">MTKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDAQKLRKATLDTLALYLACGIDPEKSTIFVQSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAENINAGLFDYPVLMAADILLYQTNLVPVGEDQKQHLELSRDIAQRFNALYGDIFKVPEPFIPKSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDVQNKAGVSNLLDILSAVTGQSIPELEKQFEGKMYGHLKGEVADAVSGMLTELQERYHRFRNDEAFLQQVMKDGAEKASAHASRTLKAVYEAIGFVAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AU4</accession>
    <name>Q32AU4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">H+/gluconate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gntU</name>
        <name evidence="2" type="ordered locus">SDY_3587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000210111.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405052.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AU4"/>
    <dbReference type="STRING" id="300267.SDY_3587"/>
    <dbReference type="EnsemblBacteria" id="ABB63561">
        <property type="protein sequence ID" value="ABB63561"/>
        <property type="gene ID" value="SDY_3587"/>
    </dbReference>
    <dbReference type="GeneID" id="66672681"/>
    <dbReference type="KEGG" id="sdy:SDY_3587"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4260"/>
    <dbReference type="HOGENOM" id="CLU_027949_0_2_6"/>
    <dbReference type="OMA" id="MGGILGH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="446" mass="46416" checksum="9BC51A785FF80A5F" modified="2005-12-06" version="1">MTTLTLVLTAVGSVLLLLFLVMKARMHAFLALMVVSMGAGLFSGMPLDKIAATMEKGMGGTLGFLAVVVALGAMFGKILHETGAVDQIAVKMLKSFGHSRAHYAIGLAGLVCALPLFFEVAIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLVPGPAPMLLASQMNADFGWMILIGLCAAIPGMIIAGPLWGNFISRYVELHIPDDISEPHLGEGKMPSFGFSLSLILLPLVLVGLKTIAARFVPEGSTAYEWFEFIGHPFTAILVACLVAIYGLAMRQGMPKDKVMEICGHALQPAGIILLVIGAGGVFKQVLVDSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATVACLTAVGLVMPVIEQLNYSGAQMAALSICIAGGSIVVSHVNDAGFWLFGKFTGATEAETLKTWTMMETILGTVGAIVGMIAFQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AU5</accession>
    <name>Q32AU5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_3586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405051.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AU5"/>
    <dbReference type="STRING" id="300267.SDY_3586"/>
    <dbReference type="EnsemblBacteria" id="ABB63560">
        <property type="protein sequence ID" value="ABB63560"/>
        <property type="gene ID" value="SDY_3586"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3586"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4259"/>
    <dbReference type="HOGENOM" id="CLU_001103_9_7_6"/>
    <dbReference type="OMA" id="LCNENTR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="227"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="385" mass="42621" checksum="F4FF5F485061357E" modified="2005-12-06" version="1">MEKHAAELLLPRMLGNTTATFREGQWEAIDAVVNQRRKLLVVQRTGWGKSAVYFIASKIFRDRGAGPTIIISPLLALMRNQVAAAERLGITAETLNSTNREEWQRISDKLLQGEVDCLLVSPERLANQDFIETVLYPIADRIGLLVVDEAHCISDWGHDFRPDYRRILDILRQLPANTPVLGTTATANNRVVEDIRQQLGDIVIQRGTLARESLALDALVLGEQSSRLAWLATVIPQFSKSGIVYTLTTRDAELVAEWLRKNGISAFAYYSGVTCEGAEDSNTAREYLEQALLANKIKVLVATTALGMGFDKPDLGFVIHYQMPGSIVGYYQQVGRAGRGIDSAVGILLCGSEDRAIHKFFRESAFPAEAQIHEILNVLSVNDGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B23</accession>
    <name>TUSB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein TusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA 2-thiouridine synthesizing protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tusB</name>
        <name type="ordered locus">SDY_3504</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DsrH/TusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000903371.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404973.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B23"/>
    <dbReference type="SMR" id="Q32B23"/>
    <dbReference type="STRING" id="300267.SDY_3504"/>
    <dbReference type="EnsemblBacteria" id="ABB63482">
        <property type="protein sequence ID" value="ABB63482"/>
        <property type="gene ID" value="SDY_3504"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3504"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4158"/>
    <dbReference type="HOGENOM" id="CLU_166087_2_1_6"/>
    <dbReference type="OMA" id="MLHTINK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01564">
        <property type="entry name" value="Thiourid_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023526">
        <property type="entry name" value="Sulphur_relay_TusB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007215">
        <property type="entry name" value="Sulphur_relay_TusB/DsrH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37526">
        <property type="entry name" value="PTHR37526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04077">
        <property type="entry name" value="DsrH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03011">
        <property type="entry name" value="sulf_tusB_dsrH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000234521" description="Protein TusB">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01564"/>
        </source>
    </evidence>
    <sequence length="95" mass="10704" checksum="0EEF7574D127CB08" modified="2005-12-06" version="1">MLHTLHRSPWLTDFAALLRLLSEGDELLLLQDGVTAAVDGNRYLESLRNAPIKVYALNEDLIARGLIGQISNDIIPIDYTDFVRLTVKHSSQMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B29</accession>
    <name>Q32B29_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">Bacterioferritin</fullName>
            <ecNumber evidence="5">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bfr</name>
        <name evidence="9" type="ordered locus">SDY_3498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 7">Belongs to the bacterioferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000675526.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404967.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B29"/>
    <dbReference type="STRING" id="300267.SDY_3498"/>
    <dbReference type="EnsemblBacteria" id="ABB63476">
        <property type="protein sequence ID" value="ABB63476"/>
        <property type="gene ID" value="SDY_3498"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3498"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4152"/>
    <dbReference type="HOGENOM" id="CLU_104506_2_0_6"/>
    <dbReference type="OMA" id="TPEMLKC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00754">
        <property type="entry name" value="bfr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00549">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0409">Iron storage</keyword>
    <keyword evidence="5 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="158" mass="18338" checksum="43EB3E704071699C" modified="2005-12-06" version="1">MKGDVKIINYLNKLLGNELVAINQYFLHARMFKNWGLMRLNDVEYHESIDEMKHADKYIERILFLEGVPNLQDLGKLGIGEDVEEMLQSDLRLELEGAKDLREAIAYADSVHDYVSRDMMIEILADEEGHIDWLETELDLIGKIGLQNYLQSQIKVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BN0</accession>
    <name>Q32BN0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altronate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">uxaA</name>
        <name evidence="4" type="ordered locus">SDY_3276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001199354.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404766.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BN0"/>
    <dbReference type="STRING" id="300267.SDY_3276"/>
    <dbReference type="EnsemblBacteria" id="ABB63275">
        <property type="protein sequence ID" value="ABB63275"/>
        <property type="gene ID" value="SDY_3276"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3276"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3917"/>
    <dbReference type="HOGENOM" id="CLU_029189_0_0_6"/>
    <dbReference type="OMA" id="MRHDKRE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="3">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="495" mass="54237" checksum="8F58CB97B3F9971E" modified="2005-12-06" version="1">MQYIKIHALDNVAVALADLAEGTEVSVDNQTVRLRQDVARGHKFALTNIAKGANVIKYGLPIGYALADIAAGEHVHAHNTRTNLSDLDQYRYQPDFQDLPAQAADREVQIYRRANGDVGVRNELWLLPTVGCVNGIARQIQNRFLKETNNTEGTDGVFLFSHTYGCSQLGDDHINTRTMLQNMVRHPNAGAVLVIGLGCENNQVAAFRETLGDIDPERVHFMICQQQDDEIEAGIEHLHQLYNVMRNDKREPGKLSELKFGLECGGSDGLSGITANPMLGRFSDYVIANGGTTVLTEVPEMFGAEQLLMDHCRDEATFEKLVTMVNDFKQYFITHDQPIYENPSPGNKAGGITTLEDKSLGCTQKAGSSVVVDVLRYGERLKTPGLNLLSAPGNDAVATSALAGAGCHMVLFSTGRGTPYGGFVPTVKIATNSELAAKKKHWIDFDAGQLIHGKAMPQLLEEFIDTIVEFANGKQTCNERNDFRELAIFKSGVTL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BP9</accession>
    <name>MUG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G/U mismatch-specific DNA glycosylase</fullName>
            <ecNumber evidence="1">3.2.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Double-strand-specific uracil glycosylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Mismatch-specific uracil DNA-glycosylase</fullName>
            <shortName evidence="1">MUG</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mug</name>
        <name type="ordered locus">SDY_3252</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.28"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds DNA as a monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.28" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000228931.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404747.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BP9"/>
    <dbReference type="SMR" id="Q32BP9"/>
    <dbReference type="STRING" id="300267.SDY_3252"/>
    <dbReference type="EnsemblBacteria" id="ABB63256">
        <property type="protein sequence ID" value="ABB63256"/>
        <property type="gene ID" value="SDY_3252"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3252"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3887"/>
    <dbReference type="HOGENOM" id="CLU_042829_3_1_6"/>
    <dbReference type="OMA" id="FWPVLHL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01956">
        <property type="entry name" value="MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023502">
        <property type="entry name" value="MUG_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="PTHR12159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000238686" description="G/U mismatch-specific DNA glycosylase">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01956"/>
        </source>
    </evidence>
    <sequence length="168" mass="18659" checksum="9CA9BBDA9A2E3F13" modified="2005-12-06" version="1">MVEDILAPGLRVVFCGINPGLSSAGTGFPFAHPANRFWKVIYQAGFTDRQLKPQEAQHLLDYRCGVTKLVDRPTVQANEISNQELHAGGRKLIEKIEDYQPQALAILGKQAYEQGFSQRGAQWGKQTLSIGSTQIWVLPNPSGLSRVSLEKLVEAYRELDQALVVRGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BR2</accession>
    <name>HLDE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein HldE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">D-beta-D-heptose 7-phosphate kinase</fullName>
                <ecNumber evidence="1">2.7.1.167</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">D-beta-D-heptose 7-phosphotransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">D-glycero-beta-D-manno-heptose-7-phosphate kinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">D-beta-D-heptose 1-phosphate adenylyltransferase</fullName>
                <ecNumber evidence="1">2.7.7.70</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">hldE</name>
        <name type="ordered locus">SDY_3235</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="ChEBI" id="CHEBI:60208"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.167"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.167" evidence="1"/>
    <dbReference type="EC" id="2.7.7.70" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000869201.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404734.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BR2"/>
    <dbReference type="SMR" id="Q32BR2"/>
    <dbReference type="STRING" id="300267.SDY_3235"/>
    <dbReference type="EnsemblBacteria" id="ABB63243">
        <property type="protein sequence ID" value="ABB63243"/>
        <property type="gene ID" value="SDY_3235"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3235"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3864"/>
    <dbReference type="HOGENOM" id="CLU_021150_2_1_6"/>
    <dbReference type="OMA" id="CEFANAA"/>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00437"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033785">
        <property type="term" value="F:heptose 7-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033786">
        <property type="term" value="F:heptose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01172">
        <property type="entry name" value="RfaE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01603">
        <property type="entry name" value="HldE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023030">
        <property type="entry name" value="Bifunc_HldE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011913">
        <property type="entry name" value="RfaE_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02198">
        <property type="entry name" value="rfaE_dom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000255783" description="Bifunctional protein HldE">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribokinase">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cytidylyltransferase">
        <location>
            <begin position="344"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01603"/>
        </source>
    </evidence>
    <sequence length="477" mass="51095" checksum="ECF0E737036E82F8" modified="2005-12-06" version="1">MKVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNITSLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQPGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTSTVSPIELENAVRGRAETGFGVMTEEELKLAVAAARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGDSRPVNPLEQRMIVLGALEAVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSKEVWANGGEVLVLNFEDGCSTTNIIKKIQQDKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BS4</accession>
    <name>Q32BS4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404722.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BS4"/>
    <dbReference type="STRING" id="300267.SDY_3223"/>
    <dbReference type="EnsemblBacteria" id="ABB63231">
        <property type="protein sequence ID" value="ABB63231"/>
        <property type="gene ID" value="SDY_3223"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3223"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3849"/>
    <dbReference type="HOGENOM" id="CLU_079314_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024289">
        <property type="entry name" value="DUF3828"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12883">
        <property type="entry name" value="DUF3828"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3828" evidence="1">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3828" evidence="1">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="199" mass="23165" checksum="5B6C4EA310B5FBDB" modified="2005-12-06" version="1">MRFRIFKDDKEKTTQTLKMVAENGRWVIDDIVSNHGSVLQAVNSENEKTLAALASLQKEQPEAFVAELFEHIADYSWPWTWVVSDSYRQAVNAFYKTTFKAANNPDEDMQIERQFIYDNPICFGEESLFSRVDEIRVLEKTADSARIHIRFTLTNGNNEEQELVLQRREDKWEITDFIRPNSGSLLKQIEAKTAARLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BW0</accession>
    <name>Q32BW0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD assembly factor SdhE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ygfY</name>
        <name evidence="4" type="ordered locus">SDY_3185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SdhE FAD assembly factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000354046.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404686.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BW0"/>
    <dbReference type="SMR" id="Q32BW0"/>
    <dbReference type="STRING" id="300267.SDY_3185"/>
    <dbReference type="EnsemblBacteria" id="ABB63195">
        <property type="protein sequence ID" value="ABB63195"/>
        <property type="gene ID" value="SDY_3185"/>
    </dbReference>
    <dbReference type="GeneID" id="67415218"/>
    <dbReference type="KEGG" id="sdy:SDY_3185"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3807"/>
    <dbReference type="HOGENOM" id="CLU_103054_2_2_6"/>
    <dbReference type="OMA" id="FEHEYDT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="SSF109910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="88" mass="10547" checksum="B7047D93220989DE" modified="2005-12-06" version="1">MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRNRERGPVAI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BW7</accession>
    <name>GCST_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminomethyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gcvT</name>
        <name type="ordered locus">SDY_3176</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000068707.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404679.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BW7"/>
    <dbReference type="SMR" id="Q32BW7"/>
    <dbReference type="STRING" id="300267.SDY_3176"/>
    <dbReference type="EnsemblBacteria" id="ABB63188">
        <property type="protein sequence ID" value="ABB63188"/>
        <property type="gene ID" value="SDY_3176"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3176"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3794"/>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_6"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000047709" description="Aminomethyltransferase">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <sequence length="364" mass="40177" checksum="EA44EBB25295E33A" modified="2005-12-06" version="1">MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQIDEHHAVRTDAGMFDVSHMTIVDLRGSRTREFLRYLLANDVAKLTKSGKALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNSATREKDLSWITQHAEPFGIEITVRDDLSMIAVQGPNAQAKAATLFNDAQRQAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIALPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYSQEMDETISPLAANMGWTIAWEPADRDFIGREALEAQREHGTEKLVGLVMTEKGVLRNELPVRFTDVQGNQHEGIITSGTFSPTLGYSIALARVPEGIGETAIVQIRNREMPVKVTKPVFVRNGKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BZ3</accession>
    <name>Q32BZ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-binding protein of ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_3149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000956896.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404653.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BZ3"/>
    <dbReference type="STRING" id="300267.SDY_3149"/>
    <dbReference type="EnsemblBacteria" id="ABB63162">
        <property type="protein sequence ID" value="ABB63162"/>
        <property type="gene ID" value="SDY_3149"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3149"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3761"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="EVMFGPL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="225" mass="25003" checksum="C790363822EC8D96" modified="2005-12-06" version="1">MLTLNQISYRWPGAATDCLCDISLQLKQGEWLALTGNNGAGKSTLLRVMAGLLTPTAGTVMLQQQAMKNLKNRQRAAKIGVLFQEAENQLFHSTVADEIAFGLKLQKCPADEITQRPHAALQCCQLADTANAHPLDLHSAQRRMVAVACLEALSPPLLLLDEPSRDFDENWLSVFESWLEKCRQRGTSVVAINHDAAFTRRHFSRVVRLEDGLIRNVNPPDDIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BZ4</accession>
    <name>Q32BZ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yggC</name>
        <name evidence="1" type="ordered locus">SDY_3148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000687772.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404652.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BZ4"/>
    <dbReference type="STRING" id="300267.SDY_3148"/>
    <dbReference type="EnsemblBacteria" id="ABB63161">
        <property type="protein sequence ID" value="ABB63161"/>
        <property type="gene ID" value="SDY_3148"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3148"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3760"/>
    <dbReference type="HOGENOM" id="CLU_067202_2_0_6"/>
    <dbReference type="OMA" id="WRIEYND"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="26849" checksum="5B6A06F2D4C7A942" modified="2005-12-06" version="1">MKIELTVNGLNVQAQYHDEEIKRVHKPLLRMLAALQTVNPQRRMVVFLCAPPGTGKSTLTTFWEYLAQQDPELPAIQTLPMDGFHHYNSWLDAHQLRPFKGAPETFDVAKLAENLRQVVEGDCTWPQYDRQKHDPVEDALHVTAPLVIVEGNWLLLDDEKWCQLAQFCDFSIFINAPATALRERLVGRKLAGGVSLADAEAFYDRTDGPNVRRVLEESLPANLTLMMTATGEYHLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C25</accession>
    <name>Q32C25_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alpha helix chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yggM</name>
        <name evidence="3" type="ordered locus">SDY_3116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000737723.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404621.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C25"/>
    <dbReference type="EnsemblBacteria" id="ABB63130">
        <property type="protein sequence ID" value="ABB63130"/>
        <property type="gene ID" value="SDY_3116"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3116"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3726"/>
    <dbReference type="HOGENOM" id="CLU_074320_0_0_6"/>
    <dbReference type="OMA" id="KVTILMK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009592">
        <property type="entry name" value="DUF1202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06717">
        <property type="entry name" value="DUF1202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221001" evidence="2">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="335" mass="38520" checksum="BFF751D77A01C27F" modified="2005-12-06" version="1">MKKLWIVGTALLMLMTGNVWADGEPPTENILKDQFKKQYHSILKLDAITLKNLDAKGNQATWSAEGDVSSSDELYTWVGQLADYELLEQTWTKDKPVKFSAMLTSKGTPASGWSVNFYSFQAAASDRGRVVDDIKTNNKYLIVNSEDFNYRFSQLKSALNTQKNSISALEKEVKALDKQMVAAQKAADAYWGKDANGKQMTREDAFKKIHQQRDEFNKQNDSEAFAVKYDKEVYQPAIAACHKQSEECYEVPIQQKRDFDINEQRRQTFLKSQKLSRKLQDDWITIEKGQYPLTMKVSEINSKKVAILMKIDDINQANERWKKDTEQLRRNGVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C43</accession>
    <name>Q32C43_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Type II secretion system core protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gspG</name>
        <name evidence="13" type="ordered locus">SDY_3096</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Type II secretion system is composed of four main components: the outer membrane complex, the inner membrane complex, the cytoplasmic secretion ATPase and the periplasm-spanning pseudopilus. Forms homomultimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP G family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001087302.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404603.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C43"/>
    <dbReference type="STRING" id="300267.SDY_3096"/>
    <dbReference type="EnsemblBacteria" id="ABB63112">
        <property type="protein sequence ID" value="ABB63112"/>
        <property type="gene ID" value="SDY_3096"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3096"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3705"/>
    <dbReference type="HOGENOM" id="CLU_091705_2_1_6"/>
    <dbReference type="OMA" id="PWRNDYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010054">
        <property type="entry name" value="Type2_sec_GspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01710">
        <property type="entry name" value="typeII_sec_gspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="12">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="151" mass="16693" checksum="8C417D365EA35918" modified="2005-12-06" version="1">MNSLSRTQKPRTGFTLLEVMVVIVILGVLASLVVPNLLGNKEKADRQKAISDIVALENALDMYRLDNGRYPTTEQGLEALIQQPANMADSRNYRTGGYIKRLPKDPWGNDYQYLSPGEKGLFDVYTLGADGQENGEGAGADIGNWNLQEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C56</accession>
    <name>Q32C56_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase-2 operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hybG</name>
        <name evidence="3" type="ordered locus">SDY_3083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000334896.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404590.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C56"/>
    <dbReference type="SMR" id="Q32C56"/>
    <dbReference type="STRING" id="300267.SDY_3083"/>
    <dbReference type="EnsemblBacteria" id="ABB63099">
        <property type="protein sequence ID" value="ABB63099"/>
        <property type="gene ID" value="SDY_3083"/>
    </dbReference>
    <dbReference type="GeneID" id="67415062"/>
    <dbReference type="KEGG" id="sdy:SDY_3083"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3690"/>
    <dbReference type="HOGENOM" id="CLU_159381_1_1_6"/>
    <dbReference type="OMA" id="HYPARVD"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="8808" checksum="8E9736BFC4EFD626" modified="2005-12-06" version="1">MCIGVPGQVLAVGEDIHQLAQVEVCGIKRDVNIALICEGNPADLLGQWVLVHVGFAMSIIDEDEAKATLDALRQMDYDITSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C69</accession>
    <name>Q32C69_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yghA</name>
        <name evidence="1" type="ordered locus">SDY_3069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000018744.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404577.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C69"/>
    <dbReference type="STRING" id="300267.SDY_3069"/>
    <dbReference type="EnsemblBacteria" id="ABB63086">
        <property type="protein sequence ID" value="ABB63086"/>
        <property type="gene ID" value="SDY_3069"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3069"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3674"/>
    <dbReference type="HOGENOM" id="CLU_010194_4_0_6"/>
    <dbReference type="OMA" id="WEVANVI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="294" mass="31534" checksum="90F87DF91791464C" modified="2005-12-06" version="1">MSHLKDPTTQYYTGEYPKQKQPTLGIQAKMTPVPDCGEKTYVGSGRLKDRKALVTGGDSGIGRAAAIAYAREGADVAISYLPVEEEDAQDVKKIIEECGRKAVLLPGDLSDEKFARSLVHEAHKALGGLDIMALVAGKQVAIPDIADLTSEQFQKTFAINVFALFWLTQEAIPLLPKGASIITTSSIQAYQPSPHLLDYAATKAAILNYSRGLAKQVAEKGIRVNIVAPGPIWTALQISGGQMQDKIPQFGQQTPMKRAGQPAELAPVYVYLASQESSYVTAEVHGVCGGEHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C87</accession>
    <name>Q32C87_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001199299.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404559.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C87"/>
    <dbReference type="STRING" id="300267.SDY_3051"/>
    <dbReference type="EnsemblBacteria" id="ABB63068">
        <property type="protein sequence ID" value="ABB63068"/>
        <property type="gene ID" value="SDY_3051"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3051"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3656"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_6"/>
    <dbReference type="OMA" id="PPYSLFW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="346" mass="38500" checksum="111739D42D4F7CD7" modified="2005-12-06" version="1">MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQPFVASTLLGATTMEQLKTNVESLHLELSEDVLAEIEAVHQVYTYPAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C91</accession>
    <name>RPPH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA pyrophosphohydrolase</fullName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(Di)nucleoside polyphosphate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rppH</name>
        <name evidence="1" type="synonym">nudH</name>
        <name type="ordered locus">SDY_3047</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. RppH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000564489.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404555.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C91"/>
    <dbReference type="SMR" id="Q32C91"/>
    <dbReference type="STRING" id="300267.SDY_3047"/>
    <dbReference type="EnsemblBacteria" id="ABB63064">
        <property type="protein sequence ID" value="ABB63064"/>
        <property type="gene ID" value="SDY_3047"/>
    </dbReference>
    <dbReference type="GeneID" id="66673303"/>
    <dbReference type="KEGG" id="sdy:SDY_3047"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3652"/>
    <dbReference type="HOGENOM" id="CLU_087195_3_2_6"/>
    <dbReference type="OMA" id="PCVGIML"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03671">
        <property type="entry name" value="Ap4A_hydrolase_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00298">
        <property type="entry name" value="Nudix_RppH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022927">
        <property type="entry name" value="RppH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000231937" description="RNA pyrophosphohydrolase">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nudix box">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00298"/>
        </source>
    </evidence>
    <sequence length="176" mass="20795" checksum="AF701FE93450C6D4" modified="2005-12-06" version="1">MIDDDGYRPNVGIVICNRQGQVMWARRFGQHSWQFPQGGINPGESAEQAMYRELFEEVGLSRKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQKWFLLQLVSGDAEINMQTSSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFASVVMSLQENTPKPQNASAYRRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CA8</accession>
    <name>Q32CA8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_3028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018164.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404538.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CA8"/>
    <dbReference type="STRING" id="300267.SDY_3028"/>
    <dbReference type="EnsemblBacteria" id="ABB63047">
        <property type="protein sequence ID" value="ABB63047"/>
        <property type="gene ID" value="SDY_3028"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3028"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3634"/>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_6"/>
    <dbReference type="OMA" id="PVCLRYG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022471">
        <property type="entry name" value="Cys_desulphurase_CdsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03392">
        <property type="entry name" value="FeS_syn_CsdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="21"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="401" mass="43286" checksum="EBEA2EF211EACFA9" modified="2005-12-06" version="1">MNVFNPAQFRAQFPALQDAGVYLDSAATALKPEAVVEATRQFYSLSAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAPDDKTIVWTRGTTESINMVAQCYARPRLQPGDEIIVSVAEHHANLVPWLMVAQQTGAKVVKLPPNAQRLPDVDLLPKLITPRSRILALGQMSNVTGGCPDLARAITFAHSAGMVVMVDGAQGAVHFPADVQQLDIDFYAFSGHKLYGPTGIGVLYGKSELLEAMSPWLGGGKMIHEVSFDGFTTQSAPWKLEAGTPNVAGVIGLSAALEWLADYDINQAENWSRSLATLAEDALAKRPGFRSFRCQDSSLLAFDFAGVHHSDMVTLLAEYGIALRAGQHCAQPLLAELGVTGTLRASFAPYNTKSDVDALVNAVDRALELLVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CL9</accession>
    <name>NORR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaerobic nitric oxide reductase transcription regulator NorR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">norR</name>
        <name type="ordered locus">SDY_2906</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; nitric oxide reduction.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62936" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62936.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000010706.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404427.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CL9"/>
    <dbReference type="SMR" id="Q32CL9"/>
    <dbReference type="STRING" id="300267.SDY_2906"/>
    <dbReference type="EnsemblBacteria" id="ABB62936">
        <property type="protein sequence ID" value="ABB62936"/>
        <property type="gene ID" value="SDY_2906"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2906"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3491"/>
    <dbReference type="HOGENOM" id="CLU_000445_125_0_6"/>
    <dbReference type="UniPathway" id="UPA00638"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01314">
        <property type="entry name" value="NorR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023944">
        <property type="entry name" value="NorR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000305625" description="Anaerobic nitric oxide reductase transcription regulator NorR">
        <location>
            <begin position="1"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="187"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="215"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="504" mass="55139" checksum="B161227F9A26B1E0" modified="2007-10-02" version="2">MSFSVDVLANIAIELQRGIGHQDRFQRLITTLRQVLECDASALLRYDLRQFIPLAIDGLAKDVLGRRFALEGHPRLEAIARAGDVVRFPADSGLPDPYDGLIPGQESLKVHACVGLPLFAGQNLIGALTLDGMQPDQFDVFSDEELRLIAALAAGALSNALLIEQLESQNMLPGDAAPFEAVKQTQMIGLSPGMTQLKKEIEIVAASDLNVLISGETGTGKELVAKAIHEASPRAVNPLVYLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLLRVLQYGDIQRVGDDRSLRVDVRVLAATNRDLREEVLAGRFRADLFHRLSVFPLSVPPLRERGDDVILLAGYFCEQCRLRQGLSRVVLSAGARNLLQHYSFPGNVRELEHAIHRAVVLARATRNGDEVILEAQHFAFPEVTLPPPEAAAVPVVKQNLREATEAFQRETIRQALAQNHHNWAACARMLETDVANLHRLAKRLGLKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CN6</accession>
    <name>LUXS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-ribosylhomocysteine lyase</fullName>
            <ecNumber evidence="1">4.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AI-2 synthesis protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Autoinducer-2 production protein LuxS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">luxS</name>
        <name type="ordered locus">SDY_2884</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17753"/>
            <dbReference type="ChEBI" id="CHEBI:29484"/>
            <dbReference type="ChEBI" id="CHEBI:58195"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.4.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LuxS family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001130211.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404410.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CN6"/>
    <dbReference type="SMR" id="Q32CN6"/>
    <dbReference type="STRING" id="300267.SDY_2884"/>
    <dbReference type="EnsemblBacteria" id="ABB62919">
        <property type="protein sequence ID" value="ABB62919"/>
        <property type="gene ID" value="SDY_2884"/>
    </dbReference>
    <dbReference type="GeneID" id="66673444"/>
    <dbReference type="KEGG" id="sdy:SDY_2884"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3468"/>
    <dbReference type="HOGENOM" id="CLU_107531_2_0_6"/>
    <dbReference type="OMA" id="GPMGCLT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043768">
        <property type="term" value="F:S-ribosylhomocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00091">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037005">
        <property type="entry name" value="LuxS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003815">
        <property type="entry name" value="S-ribosylhomocysteinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35799">
        <property type="entry name" value="PTHR35799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02664">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006160">
        <property type="entry name" value="AI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01487">
        <property type="entry name" value="LUXSPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0071">Autoinducer synthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0673">Quorum sensing</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000298031" description="S-ribosylhomocysteine lyase">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00091"/>
        </source>
    </evidence>
    <sequence length="171" mass="19416" checksum="131F57F1866DA105" modified="2005-12-06" version="1">MPLLDSFTVDHTRMEAPAVRVAKTMNTPHGDAITVFDLRFCVPNKEVMPERGIHTLEHLFAGFMRNHLNGNGVEIIDISPMGCRTGFYMSLIGTPDEQRVADAWKAAMEDVLKVQDQNQIPELNVYQCGTYQMHSLQEAQDIARSILERDVRINSNEELALPKEKLQELHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CP3</accession>
    <name>Q32CP3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_2876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000165721.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404403.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CP3"/>
    <dbReference type="STRING" id="300267.SDY_2876"/>
    <dbReference type="EnsemblBacteria" id="ABB62912">
        <property type="protein sequence ID" value="ABB62912"/>
        <property type="gene ID" value="SDY_2876"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2876"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3458"/>
    <dbReference type="HOGENOM" id="CLU_001265_23_0_6"/>
    <dbReference type="OMA" id="VQTTVAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="12"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="394" mass="41650" checksum="18DB630CAF204AA6" modified="2005-12-06" version="1">MTKPNHELSPALIVLMSIATGLAVASNYYAQPLLDTIARNFSLSASSAGFIVTAAQLGYAAGLLFLVPLGDMFERRRLIVSMTLLAAGGMLITASSQSLAMMILSTALTGLFSVVAQILVPLAATLASPDKRGKVVGTIMSGLLLGILLARTVAGLLANLGGWRTVFWVASVLMALMALALWRGLPQMKSETHLNYPQLLGSVFSMFISNKILRTRALLGSLTFANFSILWTSIAFLLAAPPFNYSDGVIGLFGLAGAAGALGARPAGGFADKGKSHHTTTFGLLLLLLSWLAIWFGHTSVLALIIGILVLDLTVQGVHITNQTVIYRIHPDARNRLTAGYMTSYFIGGAAGSLISASAWQHGGWAGVCLAGATIALVNLLVWWRGFHRQEAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CU9</accession>
    <name>Q32CU9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anti-sigma-E factor RseA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Regulator of SigE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sigma-E anti-sigma factor RseA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sigma-E factor negative regulatory protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rseA</name>
        <name evidence="10" type="ordered locus">SDY_2813</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts 1:1 with ECF RNA polymerase sigma-E (RpoE); this inhibits the interaction of sigma-E with the RNA polymerase catalytic core and leads to a decreased expression of sigma-E-regulated genes. Interacts with RseB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RseA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001168459.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404347.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CU9"/>
    <dbReference type="SMR" id="Q32CU9"/>
    <dbReference type="STRING" id="300267.SDY_2813"/>
    <dbReference type="EnsemblBacteria" id="ABB62856">
        <property type="protein sequence ID" value="ABB62856"/>
        <property type="gene ID" value="SDY_2813"/>
    </dbReference>
    <dbReference type="GeneID" id="66673539"/>
    <dbReference type="KEGG" id="sdy:SDY_2813"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3388"/>
    <dbReference type="HOGENOM" id="CLU_108851_1_0_6"/>
    <dbReference type="OMA" id="PEWNIAE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016989">
        <property type="term" value="F:sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16328">
        <property type="entry name" value="RseA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005573">
        <property type="entry name" value="Anti-sigma_E_RseA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005572">
        <property type="entry name" value="Anti-sigma_E_RseA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036147">
        <property type="entry name" value="Anti-sigma_E_RseA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026279">
        <property type="entry name" value="RseA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03873">
        <property type="entry name" value="RseA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03872">
        <property type="entry name" value="RseA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016938">
        <property type="entry name" value="RseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89069">
        <property type="entry name" value="SSF89069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RseA_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RseA_C" evidence="9">
        <location>
            <begin position="132"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="216" mass="24321" checksum="63BD12131C611C32" modified="2005-12-06" version="1">MQKEQLSALMDGETLDSELLNELAHNPEMQKTWESYHLIRDSMRGDTPEVLHFDISSRVMAAIEEEPVRQPATLIPEAQPAPHQWQKMPFWQKVRPWAAQLTQMGVAACVSLAVIVGVQHYNGQSETSQQPETPVFNTLPMMGKASPVSLGVPSEATANNGQQQQVQEQRRRINAMLQDYELQRRLHSEQLQFEQAQTQQAAVQVPGIQTLGTQSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D15</accession>
    <name>PUR4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <shortName evidence="1">FGAMS</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase</fullName>
            <shortName evidence="1">FGAR amidotransferase</shortName>
            <shortName evidence="1">FGAR-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purL</name>
        <name type="ordered locus">SDY_2747</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000970066.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404281.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D15"/>
    <dbReference type="SMR" id="Q32D15"/>
    <dbReference type="STRING" id="300267.SDY_2747"/>
    <dbReference type="EnsemblBacteria" id="ABB62790">
        <property type="protein sequence ID" value="ABB62790"/>
        <property type="gene ID" value="SDY_2747"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2747"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3312"/>
    <dbReference type="HOGENOM" id="CLU_001031_0_2_6"/>
    <dbReference type="OMA" id="LSANWMW"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264598" description="Phosphoribosylformylglycinamidine synthase">
        <location>
            <begin position="1"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="1135"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="1260"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="1262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="718"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="722"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="884"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="886"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1295" mass="141431" checksum="4901EB84F812CE69" modified="2007-12-04" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D70</accession>
    <name>Q32D70_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">upp</name>
        <name evidence="12" type="ordered locus">SDY_2687</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D70"/>
    <dbReference type="STRING" id="300267.SDY_2687"/>
    <dbReference type="EnsemblBacteria" id="ABB62735">
        <property type="protein sequence ID" value="ABB62735"/>
        <property type="gene ID" value="SDY_2687"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2687"/>
    <dbReference type="HOGENOM" id="CLU_067096_2_2_6"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="139"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="217" mass="23559" checksum="E52A0B7529E2D867" modified="2005-12-06" version="1">MAAPQRRKSMKIVEVKHPLVKHKLGLMREQDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAGLGMMDGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DC2</accession>
    <name>Q32DC2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404174.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DC2"/>
    <dbReference type="STRING" id="300267.SDY_2629"/>
    <dbReference type="EnsemblBacteria" id="ABB62683">
        <property type="protein sequence ID" value="ABB62683"/>
        <property type="gene ID" value="SDY_2629"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2629"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3167"/>
    <dbReference type="HOGENOM" id="CLU_044178_2_0_6"/>
    <dbReference type="OMA" id="CAEPNLH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="308" mass="33902" checksum="CDB5D202280EA4F9" modified="2005-12-06" version="1">MALLFSGGTMSQVQSGILPEHCRAAIWIEANVKGEVDALRAASKTFADKLATSEAKFPDAHLGAVVAFGNNTWRALSGGVGAEELKDFPGYGKGLAPTTQFDVLIHILSLRHDVNFSVAQAAMEAFGDCIEVKEEIHGFRWVEERDLSGFVDGTENPAGEETRREVAVIKDGVDAGGSYVFVQRWEHNLKQLNRMSVHDQEMMIGRTKEANEEIDGDERPETSHLTRVDLKEDGKGLKIVRQSLPYGTASGTHGLYFCAYCARLHNIEQQLLSMFGDTDGKRDAMLRFTKPVTGGYYFAPSLDKLMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DL1</accession>
    <name>Q32DL1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000559764.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404085.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DL1"/>
    <dbReference type="STRING" id="300267.SDY_2524"/>
    <dbReference type="EnsemblBacteria" id="ABB62594">
        <property type="protein sequence ID" value="ABB62594"/>
        <property type="gene ID" value="SDY_2524"/>
    </dbReference>
    <dbReference type="GeneID" id="67416755"/>
    <dbReference type="KEGG" id="sdy:SDY_2524"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3039"/>
    <dbReference type="HOGENOM" id="CLU_183014_0_0_6"/>
    <dbReference type="OMA" id="GMWENLY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014987">
        <property type="entry name" value="UPF_YfcL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08891">
        <property type="entry name" value="YfcL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="92" mass="10000" checksum="2B74338422926826" modified="2005-12-06" version="1">MIAEFESRILALIDGMVDHASDDELFASGYLRGHLTLAIAELESGDDHSAQAVHTTVSQSLEKAIGAGELSPRDQALVTDMWENLFQQASQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DP2</accession>
    <name>Q32DP2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="6 12">2.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Phosphotransacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pta</name>
        <name evidence="15" type="ordered locus">SDY_2493</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in acetate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + phosphate = acetyl phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19521"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">In the N-terminal section; belongs to the CobB/CobQ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.8" evidence="6 12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000086735.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404054.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DP2"/>
    <dbReference type="STRING" id="300267.SDY_2493"/>
    <dbReference type="EnsemblBacteria" id="ABB62563">
        <property type="protein sequence ID" value="ABB62563"/>
        <property type="gene ID" value="SDY_2493"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2493"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3005"/>
    <dbReference type="HOGENOM" id="CLU_019723_2_2_6"/>
    <dbReference type="OMA" id="FFMCLAD"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
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        </source>
    </evidence>
    <sequence length="714" mass="77186" checksum="8B8AEBCB3DC26C4A" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <sequence length="610" mass="65914" checksum="21CB61D6E1B058CE" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
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                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
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            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
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        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="5" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="68"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="169"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="351" mass="39554" checksum="5C2E9CA519347ADD" modified="2005-12-06" version="1">MSISPLFRWPNSVCHFNYCYRDPRTGKEFGLGRDRRIAITEAIQANIELLSDSGRESLIDRIKGADSITLHAWLDRYETILSERGIRPKTLLDYASKIRAIRRKLPDKPLTDISTKEVAAMLNTYVAEGKAASAKLIRSTLVDVFREAIAEGHVATNPVTATRTAKSEVRRSRLTANEYVEIYHAAEPLPIWLRLAMDLAVITGQRVGDLCRMKWSDINDNHLHIEQGKTGAKLAIPLTLTIDALNISLVDTLQKCREASSSETIIASKHHDPLSPKTVSKYFTKARNASGLSFDGDPPTFHELRSLSARLYRNQIGDKFAQRLLGHKSDSMAARYRDSRGREWDKIEINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DW5</accession>
    <name>Q32DW5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative recombination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ninB</name>
        <name evidence="1" type="ordered locus">SDY_2417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000814621.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403981.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DW5"/>
    <dbReference type="EnsemblBacteria" id="ABB62490">
        <property type="protein sequence ID" value="ABB62490"/>
        <property type="gene ID" value="SDY_2417"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2417"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2915"/>
    <dbReference type="HOGENOM" id="CLU_127009_0_0_6"/>
    <dbReference type="OMA" id="TAWAIGH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036619">
        <property type="entry name" value="NinB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008711">
        <property type="entry name" value="Recombinase_NinB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05772">
        <property type="entry name" value="NinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103370">
        <property type="entry name" value="SSF103370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="136" mass="15546" checksum="A64099794C664D1E" modified="2005-12-06" version="1">MKQTIFLRTKQQQQAAINAILSTPLDKDKPVTIRITDYKRNLDQNAKFHAMLADIARQVQWCGKWLKPEQWKVLLISGHAVATKQEADVLPGLEGECVNIRESSAQMSVKRMASLIEYTTAWAIGQGVRFTDRRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DY5</accession>
    <name>Q32DY5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001255151.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403961.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DY5"/>
    <dbReference type="STRING" id="300267.SDY_2396"/>
    <dbReference type="EnsemblBacteria" id="ABB62470">
        <property type="protein sequence ID" value="ABB62470"/>
        <property type="gene ID" value="SDY_2396"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2396"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2889"/>
    <dbReference type="HOGENOM" id="CLU_049290_2_1_6"/>
    <dbReference type="OMA" id="DTRHPAQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="276" mass="31097" checksum="820F66B8D704BDE4" modified="2005-12-06" version="1">MRRVFWLIAVALLLAGCAGEKGIVEKEGYQLDTRRQAQAAYPRIKVLVIHYTADDFDSSLATLTDKQVSSHYLVPAVPPRYNGKPRIWQLVPEQELAWHAGISAWRGATRLNDTSIGIELENRGWQKSAGVKYFAPFEPAQIQALIPLAKDIIARYHIKPENVVAHADIAPQRKDDPGPLFPWQQLAQQGIGAWPDAQRVNFYLAGRAPHTPVDTTSLLELLARYGYDVKPDMTPREQRRVIMAFQMHFRPTLYNGEADAETQAIAEALLEKYGQD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E01</accession>
    <name>CLPS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name type="ordered locus">SDY_2380</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000520781.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403945.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E01"/>
    <dbReference type="SMR" id="Q32E01"/>
    <dbReference type="STRING" id="300267.SDY_2380"/>
    <dbReference type="EnsemblBacteria" id="ABB62454">
        <property type="protein sequence ID" value="ABB62454"/>
        <property type="gene ID" value="SDY_2380"/>
    </dbReference>
    <dbReference type="GeneID" id="58462759"/>
    <dbReference type="KEGG" id="sdy:SDY_2380"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2873"/>
    <dbReference type="HOGENOM" id="CLU_134358_2_1_6"/>
    <dbReference type="OMA" id="NDDYTSM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000300726" description="ATP-dependent Clp protease adapter protein ClpS">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <sequence length="106" mass="12179" checksum="2E9DC8000EA3CE86" modified="2005-12-06" version="1">MGKTNDWLDFDQLAEEKVRDALKPPSMYKVILVNDDYTPMEFVIDVLQKFFSYDVERATQLMLAVHYQGKAICGVFTAEVAETKVAMVNKYARENEHPLLCTLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ED7</accession>
    <name>Q32ED7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403809.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ED7"/>
    <dbReference type="STRING" id="300267.SDY_2235"/>
    <dbReference type="EnsemblBacteria" id="ABB62318">
        <property type="protein sequence ID" value="ABB62318"/>
        <property type="gene ID" value="SDY_2235"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2235"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2703"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15405" checksum="7253B7DA14FD1BF4" modified="2005-12-06" version="1">MALICELDEQWGFVGSKARQHWLWYVYNTKTGGVRAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EF0</accession>
    <name>HIS8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisC</name>
        <name type="ordered locus">SDY_2220</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000108929.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403796.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EF0"/>
    <dbReference type="SMR" id="Q32EF0"/>
    <dbReference type="STRING" id="300267.SDY_2220"/>
    <dbReference type="EnsemblBacteria" id="ABB62305">
        <property type="protein sequence ID" value="ABB62305"/>
        <property type="gene ID" value="SDY_2220"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2220"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2684"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_6"/>
    <dbReference type="OMA" id="IWLNANE"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000153447" description="Histidinol-phosphate aminotransferase">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <sequence length="356" mass="39311" checksum="BB24CDAB7D98CD73" modified="2005-12-06" version="1">MSTVTITDLARENVRNLTPYQSARRLGGNGDVWLNANEYPTAVEFQLTQQTLNRYPECQPKAVIENYAQYAGVKPEQVLVSCGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSAETIGVECRTVPTLENWQLDLQGISDKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELTRGKAIVVADEAYIEFCPQASLAGWLAEYPHLAILRTLSKAFALAGLRCGFTLANEEVINLLMKVIAPYPLSTPVADIAAQALSPQGIVAMRERVAQIIAEREYLIAALKEISCVEQVFDSETNYILARFKASSAVFKSLWDQGIILRDQNKQPSLSGCLRITVGTREESQRVIDALRAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EJ0</accession>
    <name>Q32EJ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403756.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EJ0"/>
    <dbReference type="STRING" id="300267.SDY_2179"/>
    <dbReference type="EnsemblBacteria" id="ABB62265">
        <property type="protein sequence ID" value="ABB62265"/>
        <property type="gene ID" value="SDY_2179"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2179"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2634"/>
    <dbReference type="HOGENOM" id="CLU_1824013_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="141" mass="15908" checksum="3266F89C9A44B0E7" modified="2005-12-06" version="1">MPLMLLCWQYMKRKALVKLITATPELVCDVIPWVNAKAAGILSECRPQPVAEECEYATVDMLPELLVAPPWVINKKKNVIPVFDLPVLPIPAVTDITPRITELISHTDISRFSEIAQYQASQQTLFTDLPLIEKEVMHLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EJ1</accession>
    <name>Q32EJ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403755.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EJ1"/>
    <dbReference type="EnsemblBacteria" id="ABB62264">
        <property type="protein sequence ID" value="ABB62264"/>
        <property type="gene ID" value="SDY_2178"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2178"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2632"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="132" mass="15409" checksum="8A7112EE99DA5E11" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQWIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EX4</accession>
    <name>Q32EX4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ordered locus">SDY_2036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022103.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403622.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EX4"/>
    <dbReference type="STRING" id="300267.SDY_2036"/>
    <dbReference type="EnsemblBacteria" id="ABB62131">
        <property type="protein sequence ID" value="ABB62131"/>
        <property type="gene ID" value="SDY_2036"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2036"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2450"/>
    <dbReference type="HOGENOM" id="CLU_005122_0_2_6"/>
    <dbReference type="OMA" id="WAPPCRE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="615"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="798"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1148" mass="130091" checksum="119C5A916A87785C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EZ5</accession>
    <name>IRAM_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anti-adapter protein IraM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iraM</name>
        <name type="ordered locus">SDY_2015</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IraM/RssC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000872356.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403601.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EZ5"/>
    <dbReference type="SMR" id="Q32EZ5"/>
    <dbReference type="STRING" id="300267.SDY_2015"/>
    <dbReference type="EnsemblBacteria" id="ABB62110">
        <property type="protein sequence ID" value="ABB62110"/>
        <property type="gene ID" value="SDY_2015"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2015"/>
    <dbReference type="HOGENOM" id="CLU_143527_1_0_6"/>
    <dbReference type="OMA" id="FSAIWGD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01199">
        <property type="entry name" value="Anti_adapt_IraM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014448">
        <property type="entry name" value="Anti-adapter_IraM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038679">
        <property type="entry name" value="PmrD_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007036">
        <property type="entry name" value="Elb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000337887" description="Anti-adapter protein IraM">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01199"/>
        </source>
    </evidence>
    <sequence length="107" mass="12121" checksum="4ED8806AAF25446A" modified="2005-12-06" version="1">MKWVVIDTVIQPTCGISFSAIWGDMKMIIWYQSTIFLPPGSIFTPVKPGIILKDKEYPITIYNIAPFNKNLWSLLKSSQECPPGESEITNKCLHKSCIIKICPYGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F11</accession>
    <name>Q32F11_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403585.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F11"/>
    <dbReference type="STRING" id="300267.SDY_1999"/>
    <dbReference type="EnsemblBacteria" id="ABB62094">
        <property type="protein sequence ID" value="ABB62094"/>
        <property type="gene ID" value="SDY_1999"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1999"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2407"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="OMA" id="YFAAQQH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11206" checksum="2FB3A770DA4F3705" modified="2005-12-06" version="1">MSRKTQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGPLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKTTAYFAQESLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F12</accession>
    <name>Q32F12_SHIDS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
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            <authorList>
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                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
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                <person name="Peng J."/>
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                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
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            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="protein sequence ID" value="ABB62093"/>
        <property type="gene ID" value="SDY_1998"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_180637_0_0_6"/>
    <dbReference type="OMA" id="DQWNAIG"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007054">
        <property type="entry name" value="Lysis_S"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04971">
        <property type="entry name" value="Phage_holin_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="7859" checksum="F18B08191721AE98" modified="2005-12-06" version="1">MKSMDKISTGIAYGTSAGSAGYWFLQWLEQVSPSQWAAIGVLGSLLLGLLTYLTNLYFKIREDKRKAARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F17</accession>
    <name>Q32F17_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABB62088">
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    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1988"/>
    <dbReference type="HOGENOM" id="CLU_187539_0_0_6"/>
    <dbReference type="OMA" id="TEQQCLH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009954">
        <property type="entry name" value="DUF1482"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07358">
        <property type="entry name" value="DUF1482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="10416" checksum="4C2764D5A31F3AED" modified="2005-12-06" version="1">MAGYLSWLFPRCKISPKLNGTAPHFGDEMFALVLFVCYLDGGCEDIVVDVYNTEQQCLHSMSDQRIRHGGCFPIENFIDGFWRPAQEYGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F20</accession>
    <name>Q32F20_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F20"/>
    <dbReference type="STRING" id="300267.SDY_1985"/>
    <dbReference type="EnsemblBacteria" id="ABB62085">
        <property type="protein sequence ID" value="ABB62085"/>
        <property type="gene ID" value="SDY_1985"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1985"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2396"/>
    <dbReference type="HOGENOM" id="CLU_015836_0_0_6"/>
    <dbReference type="OMA" id="RFWNISG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
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        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
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            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="396"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
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            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="749"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="875" mass="94835" checksum="7AF9FD5024364E89" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F37</accession>
    <name>Q32F37_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yebH</name>
        <name evidence="5" type="ordered locus">SDY_1968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Gammaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000010115.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403559.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F37"/>
    <dbReference type="SMR" id="Q32F37"/>
    <dbReference type="STRING" id="300267.SDY_1968"/>
    <dbReference type="EnsemblBacteria" id="ABB62068">
        <property type="protein sequence ID" value="ABB62068"/>
        <property type="gene ID" value="SDY_1968"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1968"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2376"/>
    <dbReference type="HOGENOM" id="CLU_050931_0_0_6"/>
    <dbReference type="OMA" id="MTPHGWR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016718">
        <property type="entry name" value="rRNA_m1G-MeTrfase_A_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018249">
        <property type="entry name" value="MyrA_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="4">
        <location>
            <begin position="89"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="96"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018249-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018249-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="269" mass="30419" checksum="F4A154A6EC3FB6D6" modified="2005-12-06" version="1">MSFSCPLCHQPLSREKNSYICPQRHQFDMAKEGYVNLLPVQHKRSRDPGDSAEMMQARRAFLDAGHYQPLRDAIVAQLRERLDDKATAVLDIGCGEGYYTHAFADALPEITTFGLDVSKVAIKAAAKRYPQVTFCVASSHRLPFSDTSMDAIIRIYAPCKAEELARVVKPGGWVITATPGPRHLMELKGLIYNEVHLHAPHAEQLEGFTLQQSAELCYPMRLRGDEAVALLQMTPFAWRAKPEVWQTLAAKEVFDCQTDFNIHLWQRSY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FE5</accession>
    <name>RSXB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ion-translocating oxidoreductase complex subunit B</fullName>
            <ecNumber evidence="1">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Rsx electron transport complex subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsxB</name>
        <name type="ordered locus">SDY_1851</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 3 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000991798.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403451.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FE5"/>
    <dbReference type="STRING" id="300267.SDY_1851"/>
    <dbReference type="EnsemblBacteria" id="ABB61960">
        <property type="protein sequence ID" value="ABB61960"/>
        <property type="gene ID" value="SDY_1851"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1851"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2230"/>
    <dbReference type="HOGENOM" id="CLU_063448_2_0_6"/>
    <dbReference type="OMA" id="DEENCIG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00463">
        <property type="entry name" value="RsxB_RnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010207">
        <property type="entry name" value="Elect_transpt_cplx_RnfB/RsxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016463">
        <property type="entry name" value="RnfB/RsxB_Proteobac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42859:SF3">
        <property type="entry name" value="PTHR42859:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005784">
        <property type="entry name" value="Elect_transpt_RnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01944">
        <property type="entry name" value="rnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000013659" description="Ion-translocating oxidoreductase complex subunit B">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S" evidence="1">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 1" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 2" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hydrophobic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00463"/>
        </source>
    </evidence>
    <sequence length="192" mass="20518" checksum="88B844477F52A850" modified="2005-12-06" version="1">MNAIWIAVAAVSLLGLAFGAILGYASRRFAVEDDPVVEKIDEILPQSQCGQCGYPGCRPYAEAISCNGEKINRCAPGGEAVMLKIAELLNVEAQPLDGEAQELTPARMVAVIDENNCIGCTKCIQACPVDAIVGATRAMHTVMSDLCTGCNLCVDPCPTHCISLQPVAETPDSWKWDLNTIPVRIIPVEHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FH7</accession>
    <name>Q32FH7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000146159.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403419.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FH7"/>
    <dbReference type="SMR" id="Q32FH7"/>
    <dbReference type="STRING" id="300267.SDY_1817"/>
    <dbReference type="EnsemblBacteria" id="ABB61928">
        <property type="protein sequence ID" value="ABB61928"/>
        <property type="gene ID" value="SDY_1817"/>
    </dbReference>
    <dbReference type="GeneID" id="58389711"/>
    <dbReference type="KEGG" id="sdy:SDY_1817"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2190"/>
    <dbReference type="HOGENOM" id="CLU_166689_0_0_6"/>
    <dbReference type="OMA" id="GHPHELG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022597">
        <property type="entry name" value="GhoS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038241">
        <property type="entry name" value="GhoS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11080">
        <property type="entry name" value="GhoS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="96" mass="10865" checksum="722C0F845B91A855" modified="2005-12-06" version="1">MASGDLVRYVITVMLHEDTLTEINELNNYLTRDGFLLTMTDDEGNIHELGTNTFGLISTQSEEEIRELVSGLTQSATGKDPEITITTWEEWNSNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FZ5</accession>
    <name>Q32FZ5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403251.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FZ5"/>
    <dbReference type="STRING" id="300267.SDY_1636"/>
    <dbReference type="EnsemblBacteria" id="ABB61760">
        <property type="protein sequence ID" value="ABB61760"/>
        <property type="gene ID" value="SDY_1636"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1636"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1972"/>
    <dbReference type="HOGENOM" id="CLU_124197_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="163" mass="18362" checksum="16FDECD79FD56620" modified="2005-12-06" version="1">MNTLASGLASHASVSRLLYVMGRDNVFPERVFGYVHPKWRTPALNVIMVGIVALSALFFDLVTATALINFGALVALTFVNLSVFNHFWRRKGMNKSWKDHFHYLLMPLVGALTVGVLWVNLESTSLTLGLVWASLGGAYLWYLIRRYRKVPLYEGDRTPVSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FZ9</accession>
    <name>Q32FZ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403247.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FZ9"/>
    <dbReference type="STRING" id="300267.SDY_1632"/>
    <dbReference type="EnsemblBacteria" id="ABB61756">
        <property type="protein sequence ID" value="ABB61756"/>
        <property type="gene ID" value="SDY_1632"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1632"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1965"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_3_6"/>
    <dbReference type="OMA" id="KAMRWYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="470" mass="50612" checksum="B87674B830258F97" modified="2005-12-06" version="1">MTHKGDTPMTITPATHAISINPATGEQLSVLPWAGADDIENALQLVAAGFRDWRETNIDYRAEKLRDIGKALRARSEEMAQMITREMGKPINQARAEVAKSANLCDWYAEHGPAMLKAEPTLVENQQAVIEYRPLGTILAIMPWNFPLWQVMRGAVPIILAGNGYLLKHAPNVMGCAQLIAQVFKDAGIPQGVYGWLNAHNDGVSQMIKDSRIAAVTVTGSVRAGAAIGAQAGAALKKCVLELGGSDPFIVLNDADLELAVKAAIAGRYQNTGQVCAAAKRFIIEEGIASAFTERFVAAAAALKMGDPHDEDNALGPMARFDLRDKLHHQVEKTLAQGARLLLGGEKMAGAGNYYPPTVLANVTPEMTVFREEVFGPVAAITIAKDAEHALELANDSEFGLSATIFTTDETQARQMAARLECGGVFINGYCASDARVAFGGVKKSGFGRELSHFGLHEFCNIQTVWKDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G19</accession>
    <name>Q32G19_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osmotically inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">osmC</name>
        <name evidence="2" type="ordered locus">SDY_1610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000152315.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403227.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G19"/>
    <dbReference type="STRING" id="300267.SDY_1610"/>
    <dbReference type="EnsemblBacteria" id="ABB61736">
        <property type="protein sequence ID" value="ABB61736"/>
        <property type="gene ID" value="SDY_1610"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1610"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1936"/>
    <dbReference type="HOGENOM" id="CLU_106355_1_0_6"/>
    <dbReference type="OMA" id="ANCPVSQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019904">
        <property type="entry name" value="Peroxiredoxin_OsmC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03562">
        <property type="entry name" value="osmo_induc_OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="143" mass="15101" checksum="FB797DD3B7FB93A7" modified="2005-12-06" version="1">MTIHKKGQAHWEGDIKRGKGTVSTESGVRNQQPYGFNTRFEGEKGTNPEELIGAAHAACFSMALSLMLGEAGFTPTSIDATADVSLDKVDAGFAITKIALKSEVAVPGIDASTFDGIIQKAKAGCPVSQVLKAEITLDYQLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G63</accession>
    <name>Q32G63_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acid shock protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">asr</name>
        <name evidence="7" type="ordered locus">SDY_1556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for growth and/or survival at acidic conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Proteolytic processing gives rise to the active protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Asr family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000743951.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G63"/>
    <dbReference type="STRING" id="300267.SDY_1556"/>
    <dbReference type="EnsemblBacteria" id="ABB61692">
        <property type="protein sequence ID" value="ABB61692"/>
        <property type="gene ID" value="SDY_1556"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1556"/>
    <dbReference type="HOGENOM" id="CLU_102486_2_0_6"/>
    <dbReference type="OMA" id="TTHVKKH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00546">
        <property type="entry name" value="Asr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023497">
        <property type="entry name" value="Acid_shock"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008969461" description="Acid shock protein" evidence="6">
        <location>
            <begin position="31"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_5005078193" evidence="4">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023527401" description="Acid shock protein" evidence="4">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="111" mass="11537" checksum="94CC369175F0F699" modified="2005-12-06" version="1">MKKQIEGMTMKKVLALVVAAAMGLSSAAFAAETATTPAPTATTTKAAPAKTTHHKKQHKAAPAQKAQAAKKHHKNTKAEQKAPEQKAQAAKKHAGKHSHQQPAKPAAQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G67</accession>
    <name>Q32G67_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_1552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001118210.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403179.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G67"/>
    <dbReference type="STRING" id="300267.SDY_1552"/>
    <dbReference type="EnsemblBacteria" id="ABB61688">
        <property type="protein sequence ID" value="ABB61688"/>
        <property type="gene ID" value="SDY_1552"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1552"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1861"/>
    <dbReference type="HOGENOM" id="CLU_031275_0_3_6"/>
    <dbReference type="OMA" id="QEDPTDA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="344" mass="37471" checksum="B61769D11EE0D480" modified="2005-12-06" version="1">MAKPIITLNGLKIVIMLGMLVIILCGIRFAAEIIVPFILALFIAVILNPLVQHMVRWRVPRVLAASILMTIILMAMVLLLAYLGSALNELTRTLPQYRNSIMTPLQALEPLLQRVGIDVSVDQLAHYIDPNAAMTLLTNLLTQLSNAMSSIFLLLLTVLFMLLEVPQLPGKFQQMMARPVEGMAAIQRAIGSVSHYLVLKTAISIITGLVAWAMLAALDVRFAFVWGLLAFALNYIPNIGSVLAAIPPIAQVLVFNGFYEALLVLAGYLLINLVFGNILEPRIMGRGLGLSTLVVFLSLIFWGWLLGPVGMLLSVPLTIIVKIALEQTAGGQSIAVLLSDLNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GK9</accession>
    <name>Q32GK9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiol peroxidase</fullName>
            <shortName evidence="2">Tpx</shortName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peroxiredoxin tpx</fullName>
            <shortName evidence="2">Prx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">tpx</name>
        <name evidence="4" type="ordered locus">SDY_1402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. Tpx subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000084387.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403037.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GK9"/>
    <dbReference type="SMR" id="Q32GK9"/>
    <dbReference type="STRING" id="300267.SDY_1402"/>
    <dbReference type="PeroxiBase" id="6004">
        <property type="entry name" value="SdyTPx01"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61546">
        <property type="protein sequence ID" value="ABB61546"/>
        <property type="gene ID" value="SDY_1402"/>
    </dbReference>
    <dbReference type="GeneID" id="58461552"/>
    <dbReference type="KEGG" id="sdy:SDY_1402"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1663"/>
    <dbReference type="HOGENOM" id="CLU_042529_12_2_6"/>
    <dbReference type="OMA" id="ITQEPNY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00269">
        <property type="entry name" value="Tpx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="168" mass="17835" checksum="F95F39094A07DBB2" modified="2005-12-06" version="1">MSQTVHFQGNPVTVANSIPQAGSKAQTFTLVAKDLSDVTLGQFAGKRKVLNIFPSIDTGVCAASVRKFNQLATEIDNTVVLCISADLPFAQSRFCGAEGLNNVITLSTFRNAEFLQAYGVAIADGPLKGLAARAVVVIDENDNVIFSQLVDEITTEPDYEAALAVLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GM3</accession>
    <name>Q32GM3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GM3"/>
    <dbReference type="STRING" id="300267.SDY_1387"/>
    <dbReference type="EnsemblBacteria" id="ABB61532">
        <property type="protein sequence ID" value="ABB61532"/>
        <property type="gene ID" value="SDY_1387"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1387"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_2_6"/>
    <dbReference type="OMA" id="NEDNSPA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="138" mass="16087" checksum="1B1B194A49267C0F" modified="2005-12-06" version="1">MCQVFGVSRSGYYNWVQHEPSDRKQSDERLKLEIKVAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQDGWLYLAGIKRCLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GV0</accession>
    <name>Q32GV0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative potassium channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">kch</name>
        <name evidence="4" type="ordered locus">SDY_1308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378679.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402946.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GV0"/>
    <dbReference type="STRING" id="300267.SDY_1308"/>
    <dbReference type="EnsemblBacteria" id="ABB61455">
        <property type="protein sequence ID" value="ABB61455"/>
        <property type="gene ID" value="SDY_1308"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1308"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1555"/>
    <dbReference type="HOGENOM" id="CLU_057267_1_0_6"/>
    <dbReference type="OMA" id="YGELTEP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0407">Ion channel</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="245"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="417" mass="46107" checksum="A65CB259E088FCA9" modified="2005-12-06" version="1">MSHWATFKQTATNLWVTLRHDILALAVFLNGLLIFKTIYGMSVNLLDIFHIKAFSELDLSLLANAPLFMLGVFLVLNSIGLLFRAKLAWAISIILLLIALIYTLHFYPWLKFSIGFCIFTLVFLLILRKDFSHSSAAAGTIFAFISFTTLLFYSTYGALYLSEGFNPRIESLMTAFYFSIETMSTVGYGDIVPVSESARLFTISVIISGITVFATSMTSIFGPLIRGGFNKLVKGNNHTMHREDHFIVCGHSILAINTILQLNQRGQNVTVISNLPEDDIKQLEQRLGDNADVIPGDSNDSSVLKKAGIDRCRAILALSDNDADNAFVVLSAKDMSSDVKTVLAVSDSKNLNKIKMVHPDIILSPQLFGSEILARVLNGEEINNDMLVSMLLNSGHGIFSDNDEQETKADSKESVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GX5</accession>
    <name>Q32GX5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nitrate reductase 1, cytochrome b(NR), gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">narI</name>
        <name evidence="15" type="ordered locus">SDY_1282</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001160113.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402921.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GX5"/>
    <dbReference type="STRING" id="300267.SDY_1282"/>
    <dbReference type="EnsemblBacteria" id="ABB61430">
        <property type="protein sequence ID" value="ABB61430"/>
        <property type="gene ID" value="SDY_1282"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1282"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1521"/>
    <dbReference type="HOGENOM" id="CLU_092378_1_0_6"/>
    <dbReference type="OMA" id="LFHWGIW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB61430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="225" mass="25499" checksum="8CB143F0B60A466B" modified="2005-12-06" version="1">MQFLNMFFFDIYPYIAGAVFLIGSWLRYDYGQYTWRAASSQMLDRKGMNLASNLFHIGILGIFVGHFFGMLTPHWMYEAWLPIEVKQKMAMFAGGASGVLCLIGGVLLLKRRLYSPRVRATTTGADILILSLLVIQCALGLLTIPFSAQHMDGSEMMKLVGWAQSVVTFHGGASQHLDGVAFIFRLHLVLGMTLFLLFPFSRLVHIWSVPVEYLTRKYQLVRARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GZ3</accession>
    <name>Q32GZ3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglut_core2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ychA</name>
        <name evidence="3" type="ordered locus">SDY_1263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0162 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001257060.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402903.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GZ3"/>
    <dbReference type="STRING" id="300267.SDY_1263"/>
    <dbReference type="EnsemblBacteria" id="ABB61412">
        <property type="protein sequence ID" value="ABB61412"/>
        <property type="gene ID" value="SDY_1263"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1263"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1500"/>
    <dbReference type="HOGENOM" id="CLU_063810_0_0_6"/>
    <dbReference type="OMA" id="LWIAAEH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="269" mass="30804" checksum="B092BAC4839C0C02" modified="2005-12-06" version="1">MRSLADFEFNKAPLCEGMILACEAIRRDVPSQDVYDELERLVSLAKEEISQLLPLEEQLEKLIALFYGDWGFKASRGVYRLSDALWLDQVLKNRQGSAVSLGAVLLWVANRLDLPLLPVIFPTQLILRIECPDGEIWLINPFNGESLSEYMLDVWLKGNISPSAELFYEDLDEADNIEVIRKLLDTLKASLMEENQMELALRTSEALLQFNPEDPYEIRDRGLIYAQLDCEHVALNDLSYFVELCPEDPISEMIRAQINNIAHKHIVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H23</accession>
    <name>Q32H23_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1232</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000051550.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402873.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H23"/>
    <dbReference type="STRING" id="300267.SDY_1232"/>
    <dbReference type="MEROPS" id="S66.002"/>
    <dbReference type="EnsemblBacteria" id="ABB61383">
        <property type="protein sequence ID" value="ABB61383"/>
        <property type="gene ID" value="SDY_1232"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1232"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1461"/>
    <dbReference type="HOGENOM" id="CLU_034346_0_1_6"/>
    <dbReference type="OMA" id="MLTQWRL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="169"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="304" mass="33575" checksum="EA404E37F37D501F" modified="2005-12-06" version="1">MSLFHLIAPSGYCIKQHAALRGIQRLTDAGHQVNNVEVIARRCERFAGTETERLEDLNSLARLPPPNTIVLAVRGGYGASRLLADIDWQALVARQQYDPLLICGHSDFTAIQCGLLAQGNVITFSGPMLVANFGADELNAFTEHHFWLALRNETFTIEWQGEGPTCRAEGTLWGGNLAMLISLIGTPWMPQIENGILVLEDINEHPFRVERMLLQLYHAGILPRQKAIILGSFSGSTPNDYDAGYNLESVYAFLRSRLSIPLITGLDFGHEQRTVTLPLGAHAMLNNTHEGTQLTISGHPVLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HM9</accession>
    <name>Q32HM9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000086764.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402667.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HM9"/>
    <dbReference type="EnsemblBacteria" id="ABB61176">
        <property type="protein sequence ID" value="ABB61176"/>
        <property type="gene ID" value="SDY_1011"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1011"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1179"/>
    <dbReference type="HOGENOM" id="CLU_111986_0_0_6"/>
    <dbReference type="OMA" id="DFERICM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="214" mass="25142" checksum="F72AD46CB1771522" modified="2005-12-06" version="1">MSRIITTTVYTLHELSSTAQEKARDWYRVHHSDSNWYENVYEDFREVCDIFGIDLRQRVFRLSNGKFMEEPCIWFSGFCSQGDGACFEGRWHWQSATARRIREHAPQERELHRIADTQQAVQKRNFWQLQAEISHRGRYCHPYSMDITVTRNSPTGQAMTTDAEAAVNEALHDLAFWLYRQLENEYDWLTSDTAVDEALLINEYTFTEAGLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HP1</accession>
    <name>Q32HP1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Curli production assembly/transport component CsgF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">csgF</name>
        <name evidence="5" type="ordered locus">SDY_0998</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the biogenesis of curli organelles.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001264087.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402655.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HP1"/>
    <dbReference type="STRING" id="300267.SDY_0998"/>
    <dbReference type="EnsemblBacteria" id="ABB61164">
        <property type="protein sequence ID" value="ABB61164"/>
        <property type="gene ID" value="SDY_0998"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0998"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1166"/>
    <dbReference type="HOGENOM" id="CLU_136740_0_0_6"/>
    <dbReference type="OMA" id="TFNYQWL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018893">
        <property type="entry name" value="T8SS_CsgF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10614">
        <property type="entry name" value="CsgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220754" description="Curli production assembly/transport component CsgF" evidence="4">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="138" mass="15088" checksum="7928FB19D13CBC28" modified="2005-12-06" version="1">MRVKHAVVLLMLISPLSWAGTMTFQFRNPNFGGNPNNGAFLLNSAQAQNSYKDPSYNDDFGIETPSALDNFTQAIQSQILGGLLSNINTGKPGRMVTNDYIVDIANRDGQLQLNMTDRKTGQTSTIQVSGLQNNSTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HW8</accession>
    <name>Q32HW8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HW8"/>
    <dbReference type="STRING" id="300267.SDY_0911"/>
    <dbReference type="EnsemblBacteria" id="ABB61087">
        <property type="protein sequence ID" value="ABB61087"/>
        <property type="gene ID" value="SDY_0911"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0911"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="52"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="108" mass="12564" checksum="A81CA33DD369A516" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HY6</accession>
    <name>NDPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein YejK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yejK</name>
        <name type="ordered locus">SDY_0893</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YejK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000050789.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402560.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HY6"/>
    <dbReference type="SMR" id="Q32HY6"/>
    <dbReference type="STRING" id="300267.SDY_0893"/>
    <dbReference type="EnsemblBacteria" id="ABB61069">
        <property type="protein sequence ID" value="ABB61069"/>
        <property type="gene ID" value="SDY_0893"/>
    </dbReference>
    <dbReference type="GeneID" id="66673917"/>
    <dbReference type="KEGG" id="sdy:SDY_0893"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1034"/>
    <dbReference type="HOGENOM" id="CLU_063050_0_1_6"/>
    <dbReference type="OMA" id="FFMDFLA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00730">
        <property type="entry name" value="NdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007358">
        <property type="entry name" value="Nucleoid_associated_NdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38772">
        <property type="entry name" value="PTHR38772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04245">
        <property type="entry name" value="NA37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000045952" description="Nucleoid-associated protein YejK">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00730"/>
        </source>
    </evidence>
    <sequence length="335" mass="37823" checksum="B4B42927767CA9E6" modified="2005-12-06" version="1">MSLDINQIALHQLIKRDEQNLELVLRDSLLEPTETVVEMVAELHRVYSAKNKAYGLFSEESELAQTLRLQRQGEEDFLAFSRAATGRLRDELAKYPFADGGFVLFCHYRYLAVEYLLVAVLSNLSSMRVNENLDINPTHYLDINHADIVARIDLTEWETNPESTRYLTFLKGRVGRKVADFFMDFLGASEGLNAKAQNRGLLQAVDDFTAEAQLDKAERQNVRQQVYSYCNEQLQAGEEIELESLSKELAGVSEVSFTEFAAEKGYELEESFPADRSTLRQLTKFAGSGGGLTINFDAMLLGERIFWDPATDTLTIKGTPPNLRDQLQRRTSGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I26</accession>
    <name>Q32I26_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402520.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I26"/>
    <dbReference type="STRING" id="300267.SDY_0850"/>
    <dbReference type="EnsemblBacteria" id="ABB64513">
        <property type="protein sequence ID" value="ABB64513"/>
        <property type="gene ID" value="SDY_0850"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0850"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.983"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="WENTAIK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="267" mass="31038" checksum="D88C98DD868C8882" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSGLAECESTMDCYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I32</accession>
    <name>Q32I32_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybjG</name>
        <name evidence="3" type="ordered locus">SDY_0843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000892317.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402514.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I32"/>
    <dbReference type="SMR" id="Q32I32"/>
    <dbReference type="STRING" id="300267.SDY_0843"/>
    <dbReference type="EnsemblBacteria" id="ABB61025">
        <property type="protein sequence ID" value="ABB61025"/>
        <property type="gene ID" value="SDY_0843"/>
    </dbReference>
    <dbReference type="GeneID" id="66670885"/>
    <dbReference type="KEGG" id="sdy:SDY_0843"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.970"/>
    <dbReference type="HOGENOM" id="CLU_072573_8_2_6"/>
    <dbReference type="OMA" id="FLFWHRV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03385">
        <property type="entry name" value="PAP2_BcrC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033879">
        <property type="entry name" value="UPP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="57"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="198" mass="22419" checksum="A1F39A75CEF3903A" modified="2005-12-06" version="1">MLENLNLSLFSLINATPDSAPWMISLAIFIAKDLITVVPLLAAVLWLWGLTAQRQLVIKIAIALAVSLFVSWTMGHLFPHDRPFVENIGYNFLHHAADDSFPSDHGTVIFTFALAFLCWHRLWSGSLLMVLAVVIAWSRVYLGVHWPLDMLGGLLAGMIGCLSAQIIWQAMGHKLYQRLQSWYRFCFALPIRKGWVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I41</accession>
    <name>Q32I41_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ipaH_1</name>
        <name evidence="13" type="ordered locus">SDY_0834</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LRR-containing bacterial E3 ligase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000801157.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402505.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I41"/>
    <dbReference type="STRING" id="300267.SDY_0834"/>
    <dbReference type="EnsemblBacteria" id="ABB61016">
        <property type="protein sequence ID" value="ABB61016"/>
        <property type="gene ID" value="SDY_0834"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0834"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.961"/>
    <dbReference type="HOGENOM" id="CLU_018533_2_0_6"/>
    <dbReference type="OMA" id="TQFPQNL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032674">
        <property type="entry name" value="LRR_E3_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029487">
        <property type="entry name" value="NEL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14496">
        <property type="entry name" value="NEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12468">
        <property type="entry name" value="TTSSLRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="TTSSLRR" evidence="11">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="NEL" evidence="12">
        <location>
            <begin position="303"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB61016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="587" mass="66473" checksum="79FE09C13F679780" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I91</accession>
    <name>DPS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA protection during starvation protein</fullName>
            <ecNumber evidence="2">1.16.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dps</name>
        <name type="ordered locus">SDY_0783</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:48712"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EC" id="1.16.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000100800.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402455.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I91"/>
    <dbReference type="SMR" id="Q32I91"/>
    <dbReference type="STRING" id="300267.SDY_0783"/>
    <dbReference type="EnsemblBacteria" id="ABB60966">
        <property type="protein sequence ID" value="ABB60966"/>
        <property type="gene ID" value="SDY_0783"/>
    </dbReference>
    <dbReference type="GeneID" id="67413850"/>
    <dbReference type="KEGG" id="sdy:SDY_0783"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.902"/>
    <dbReference type="HOGENOM" id="CLU_098183_1_2_6"/>
    <dbReference type="OMA" id="DDYSIGR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01441">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023067">
        <property type="entry name" value="Dps_gammaproteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00819">
        <property type="entry name" value="DPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0226">DNA condensation</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0409">Iron storage</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000271595" description="DNA protection during starvation protein">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
            <note>ligand shared between two dodecameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
            <note>ligand shared between two dodecameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
            <note>ligand shared between two dodecameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01441"/>
        </source>
    </evidence>
    <sequence length="167" mass="18695" checksum="596A79B1C6A5E60B" modified="2007-01-23" version="3">MSTAKLVKSKATNLLYTRNDVSDSEKKATVELLNRQVIQFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTALIDHLDTMAERAVQLGGVALGTTQVINSKTPLKSYPLDIHNVQDHLKELADRYAIVANDVRKAIGEAKDDDTADILTAASRDLDKFLWFIESNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IL0</accession>
    <name>Q32IL0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase cytochrome b556 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">sdhC</name>
        <name evidence="14" type="ordered locus">SDY_0659</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Membrane-anchoring subunit of succinate dehydrogenase (SDH).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="12">The heme is bound between the two transmembrane subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome b560 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402336.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IL0"/>
    <dbReference type="SMR" id="Q32IL0"/>
    <dbReference type="STRING" id="300267.SDY_0659"/>
    <dbReference type="EnsemblBacteria" id="ABB60847">
        <property type="protein sequence ID" value="ABB60847"/>
        <property type="gene ID" value="SDY_0659"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0659"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.770"/>
    <dbReference type="HOGENOM" id="CLU_094691_2_1_6"/>
    <dbReference type="OMA" id="YHLVAGI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045281">
        <property type="term" value="C:succinate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="PTHR10978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000178">
        <property type="entry name" value="SDH_cyt_b560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared with second transmembrane subunit</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000178-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB60847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="129" mass="14299" checksum="57485D25D2535818" modified="2005-12-06" version="1">MIRNVKKQRPVNLDLQTIRFPITAIASILHRVSGVITFVAVGILLWLLGTSLSSPEGFEQASAIMGSFFVKFIMWGILTALAYHVVVGIRHMMMDFGYLEETFEAGKRSAKISFVITVVLSLLAGVLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IP6</accession>
    <name>Q32IP6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402300.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IP6"/>
    <dbReference type="STRING" id="300267.SDY_0618"/>
    <dbReference type="EnsemblBacteria" id="ABB60811">
        <property type="protein sequence ID" value="ABB60811"/>
        <property type="gene ID" value="SDY_0618"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0618"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.717"/>
    <dbReference type="HOGENOM" id="CLU_140259_0_0_6"/>
    <dbReference type="OMA" id="WRGQVIF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005318">
        <property type="entry name" value="OM_porin_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34596">
        <property type="entry name" value="PTHR34596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220778" evidence="2">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="120" mass="13220" checksum="EA2AF9ECB8C57D56" modified="2005-12-06" version="1">MRTFSGKRSTLALAIAGVTAMSGFMAMPEARAEGFIDDSTLTGGIYYWQRERDRKDVTDGDKYKTNLSHSTWNANLDFQSGYAADMFGLDIAAFTAIEMAENGDSSHPNEIAFSKSNKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IU1</accession>
    <name>Q32IU1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">holA</name>
        <name evidence="7" type="ordered locus">SDY_0562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000620526.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402255.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IU1"/>
    <dbReference type="STRING" id="300267.SDY_0562"/>
    <dbReference type="EnsemblBacteria" id="ABB60766">
        <property type="protein sequence ID" value="ABB60766"/>
        <property type="gene ID" value="SDY_0562"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0562"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.664"/>
    <dbReference type="HOGENOM" id="CLU_044694_0_2_6"/>
    <dbReference type="OMA" id="RIPTGKP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032780">
        <property type="entry name" value="DNA_pol3_delt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14840">
        <property type="entry name" value="DNA_pol3_delt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="5">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_delt_C" evidence="6">
        <location>
            <begin position="214"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="343" mass="38709" checksum="72B741D6389D5EE8" modified="2005-12-06" version="1">MIRLYPEQLRAQLNEGLRAAYLLLGNDPLLLQESQDAVRQVAAAQGFEEHHTFSIDPNTDWNAIFSLCQAMSLFASRQTLLLLLPENGPNAAINEQLLTLTGLLHDDLLLIVRGNKLSKAQENAAWFTALANRSVQVTCQTPEQAQLPRWVAAHAKQLNLELDDAANQVLCYCYEGNLLALAQALERLSLLWPDGKLTLPRVERAVNDAAHFTPFHWVDALLMGKSKRALHILQQLRLEGSEPVILLRTLQRELLLLVNLKRQSAHTPLRALFDKHRVWQNRRGMMGEALNRLSQPQLRQAVQLLTRTELTLKQDYGQSVWAELEGLSLLLCHKPLADVFIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IZ5</accession>
    <name>Q32IZ5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine transport system periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tauA</name>
        <name evidence="4" type="ordered locus">SDY_0505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001018407.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402201.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IZ5"/>
    <dbReference type="STRING" id="300267.SDY_0505"/>
    <dbReference type="EnsemblBacteria" id="ABB60712">
        <property type="protein sequence ID" value="ABB60712"/>
        <property type="gene ID" value="SDY_0505"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0505"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.596"/>
    <dbReference type="HOGENOM" id="CLU_028871_3_1_6"/>
    <dbReference type="OMA" id="FIWDPVL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13560">
        <property type="entry name" value="PBP2_taurine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010068">
        <property type="entry name" value="Peri-bd_TauA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF38">
        <property type="entry name" value="PTHR30024:SF38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01729">
        <property type="entry name" value="taurine_ABC_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220872" evidence="2">
        <location>
            <begin position="23"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="24"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="320" mass="34251" checksum="962893BE35D50456" modified="2005-12-06" version="1">MAISSRNTLLAALAFIAFQAQAVNVTVAYQTSAEPAKVAQADNTFAKESGANVDWRKFDSGASIVRALASGDVQIGNLGSSPLAVAASQQVPIEVFLLASKLGNSEALVVKKTISKPEDLIGKRIAVPFISTTHYSLLAALKHWGIKPGQVEIVNLQPPAIIAAWQQGDIDGAYVWAPAVNALEKDGKVLTDSEQVGQWGAPTLDVWVVRKDFAEKHPEVVKAFAKSAIDAQQPYIANPDVWLKQPENISKLARLSGVPEGDVPGLVKGNTYLTPQQQTAELTGPVNKAIIDTAQFLKEQGKVPAVANDYSQYVTSRFVQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J22</accession>
    <name>FRSA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Esterase FrsA</fullName>
            <ecNumber evidence="1">3.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frsA</name>
        <name type="ordered locus">SDY_0478</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of esters.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a carboxylic ester + H2O = a carboxylate + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:33308"/>
            <dbReference type="EC" id="3.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FrsA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000189527.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402174.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J22"/>
    <dbReference type="SMR" id="Q32J22"/>
    <dbReference type="STRING" id="300267.SDY_0478"/>
    <dbReference type="ESTHER" id="shifl-yafa">
        <property type="family name" value="Duf_1100-R"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60685">
        <property type="protein sequence ID" value="ABB60685"/>
        <property type="gene ID" value="SDY_0478"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0478"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.563"/>
    <dbReference type="HOGENOM" id="CLU_036819_0_0_6"/>
    <dbReference type="OMA" id="NIPWVDH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01063">
        <property type="entry name" value="FrsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043423">
        <property type="entry name" value="FrsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <feature type="chain" id="PRO_1000064489" description="Esterase FrsA">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01063"/>
        </source>
    </evidence>
    <sequence length="414" mass="46990" checksum="0F004B39991938AC" modified="2005-12-06" version="1">MTQANLSETLFKPRFKHPETSTLVHRFNHGAQPPVQSALDGKTIPHWYRMINRLMWIWRGIDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWATQAMVWQQKACAEEDPQLGGRHWLHAATLYNIAAYPHLKGDDLAEQAQALSNRAYEEAAQRLPGTMRQMEFTVPGGAPITGFLHMPKGDGPFPTVLMCGGLDAMQTDYYSLYERYFAPRGIAMLTIDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLESPRLKAVACLGPVVHTLLSDFKCQQQVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGYWKNDPFSLEEDSRLITSSSADGKLLEIPFNPVYRNFDKGLQEITDWIEKRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J76</accession>
    <name>Q32J76_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J76"/>
    <dbReference type="STRING" id="300267.SDY_0420"/>
    <dbReference type="EnsemblBacteria" id="ABB60631">
        <property type="protein sequence ID" value="ABB60631"/>
        <property type="gene ID" value="SDY_0420"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0420"/>
    <dbReference type="HOGENOM" id="CLU_015520_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019960">
        <property type="entry name" value="T1SS_VCA0849"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03661">
        <property type="entry name" value="T1SS_VCA0849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="444" mass="45764" checksum="EF6D03C461E6375E" modified="2005-12-06" version="1">MGATATTYASQFSLAVDWNHDGLMDIARIAQTGQSYLYTNVGGASNWTQSALGGSQSGTTSGVAAMDYDWDGAVDVLVTKQSGSVFLIRNTNTVSYGTSLHLRITDPNGINVYYGNTVKLYNSAGVLVATQIINPQSGMGVNDTSALVNFYGLNAGETYSAVLIKSTGTTASNIDQTVNTSWGGLQATDATHAYDLSAEAGTASNNGKFVGTGYNDTFFATAGTDTYDGSGGWVYSSGTGTWLANGGMDVVYFRLSTVGVTANLSITAVQATGFNTSTFTNIEGISGSNFNDTLTGSSGDNQLEGRGGNDTLNIGNGGNDTLLYKLLNASDATGGNGSDVVNGFTVGTWEGTADTDRIDIRELLQGSGYTGNGKASYVNGVATLDAQAGNIGDFVKVTQSGSDTIVQIDRDGTGGTFATTNVVTLTGVHTDLATLPANHQLMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JA4</accession>
    <name>Q32JA4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybaZ</name>
        <name evidence="2" type="ordered locus">SDY_0391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402092.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JA4"/>
    <dbReference type="STRING" id="300267.SDY_0391"/>
    <dbReference type="EnsemblBacteria" id="ABB60603">
        <property type="protein sequence ID" value="ABB60603"/>
        <property type="gene ID" value="SDY_0391"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0391"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.464"/>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_6"/>
    <dbReference type="OMA" id="PRHSRHV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="129" mass="14407" checksum="584EA2BB657919D4" modified="2005-12-06" version="1">MLVSCAMLLHSGVFPDYAEKLPQEEKMEKEDSFPQRVWQIVAAIPEGYVTTYGDVAKLAGSPRAARQVGGVLKRLPEGSTLPWHRVVNRHGTISLTGPDLQRQRQALLAEGVMVSGSGQIDLQRYRWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JA6</accession>
    <name>Q32JA6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">amtB</name>
        <name evidence="11" type="ordered locus">SDY_0388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000685038.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402090.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JA6"/>
    <dbReference type="STRING" id="300267.SDY_0388"/>
    <dbReference type="EnsemblBacteria" id="ABB60601">
        <property type="protein sequence ID" value="ABB60601"/>
        <property type="gene ID" value="SDY_0388"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0388"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.460"/>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_6"/>
    <dbReference type="OMA" id="MACWNSN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221136" description="Ammonium transporter" evidence="9">
        <location>
            <begin position="23"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="10">
        <location>
            <begin position="33"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="428" mass="44522" checksum="0DD72A21FF01803D" modified="2005-12-06" version="1">MKIATIKTGLASLAMLPGLVMAAPAVADKADNAFMMICTALVLFMTIPGIALFYGGLIRGKNVLSMLTQVTVTFALVCILWVVYGYSLAFGEGNNFFGNINWLMLKNIELTAVMGSIYQYIHVAFQGSFACITVGLIVGALAERIRFSAVLIFVVVWLTLSYIPIAHMVWGGGLLASHGALDFAGGTVVHINAAITGLVGAYLIGKRVGFGKEAFKPHNLPMVFTGTAILYIGWFGFNAGSAGTANEIAALAFVNTVVATAAAILGWIFGEWALRGKPSLLGACSGAIAGLVGVTPACGYIGVGGALIIGVVAGLAGLWGVTMLKRLLRVDDPCDVFGVHGVCGIVGCIMPGIFAASSLGGVGFAEGVTMGHQLLVQLESIAITIVWSGVVAFIGYKLADLTVGLHVPEEQEREGLDVNSHGENAYNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JI4</accession>
    <name>YAJQ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0234 protein YajQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yajQ</name>
        <name type="ordered locus">SDY_0304</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0234 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60523" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60523.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001138898.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402012.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JI4"/>
    <dbReference type="SMR" id="Q32JI4"/>
    <dbReference type="STRING" id="300267.SDY_0304"/>
    <dbReference type="EnsemblBacteria" id="ABB60523">
        <property type="protein sequence ID" value="ABB60523"/>
        <property type="gene ID" value="SDY_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0304"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.349"/>
    <dbReference type="HOGENOM" id="CLU_099839_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000261977" description="UPF0234 protein YajQ">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="163" mass="18413" checksum="CDBD1D4EB06301D6" modified="2008-01-15" version="2">MPSFDIVSEVDLQEARNAVDNASREVESRFDFRNVEASFELNDARKTIKVLSESDFQVNQLLDILRAKLLKRGIEGSSLDVPENIVHSGKTWFVEAKLKQGIESATQKKIVKMIKDSKLKVQAQIQGDEIRVTGKSRDDLQAVMAMVRGGDLGQPFQFKNFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JI6</accession>
    <name>Q32JI6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JI6"/>
    <dbReference type="EnsemblBacteria" id="ABB60521">
        <property type="protein sequence ID" value="ABB60521"/>
        <property type="gene ID" value="SDY_0302"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0302"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8038" checksum="8C403CE1DFB7B8E0" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITRSALHYVGIFLRGGNERL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JL0</accession>
    <name>SYC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="1">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysS</name>
        <name type="ordered locus">SDY_0278</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000912364.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401986.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JL0"/>
    <dbReference type="SMR" id="Q32JL0"/>
    <dbReference type="STRING" id="300267.SDY_0278"/>
    <dbReference type="EnsemblBacteria" id="ABB60497">
        <property type="protein sequence ID" value="ABB60497"/>
        <property type="gene ID" value="SDY_0278"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0278"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.318"/>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_6"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000240955" description="Cysteine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <sequence length="461" mass="52200" checksum="B72F6E5B1F570152" modified="2005-12-06" version="1">MLKIFNTLTRQKEEFKPIHAGEVGMYVCGITVYDLCHIGHGRTFVAFDVVARYLRFLGYKLKYVRNITDIDDKIIKRANENGESFVALVDRMIAEMHKDFNALNILRPDMEPRATHHIAEIIELTEQLIAKGHAYVVDNGDVMFDVPTDPTYGVLSRQDLDQLLAGARVDVVDDKRNTMDFVLWKMSKEGEPSWPSPWGAGRPGWHIECSAMNCKQLGNHFDIHGGGSDLMFPHHENEIAQSTCAHDGQYVNYWMHSGMVMVDREKMSKSLGNFFTVRDVLKYYDAETVRYFLMSGHYRSQLNYSEENLKQARAALERLYTALRGTDKTVAPAGGEAFEARFIEAMDDDFNTPEAYSVLFDMAREVNRLKAEDMAAANAMASHLRKLSAVLGLLEQEPEAFLQSGAQADDSEVAEIEALIQQRLDARKAKDWAAADAARDRLNEMGIVLEDGPQGTTWRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JR5</accession>
    <name>Q32JR5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper homeostasis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cutF</name>
        <name evidence="3" type="ordered locus">SDY_0211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000239185.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401931.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JR5"/>
    <dbReference type="STRING" id="300267.SDY_0211"/>
    <dbReference type="EnsemblBacteria" id="ABB60442">
        <property type="protein sequence ID" value="ABB60442"/>
        <property type="gene ID" value="SDY_0211"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0211"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.245"/>
    <dbReference type="HOGENOM" id="CLU_1219320_0_0_6"/>
    <dbReference type="OMA" id="GTWVMNQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007298">
        <property type="entry name" value="Cu-R_lipoprotein_NlpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033450">
        <property type="entry name" value="NlpE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038139">
        <property type="entry name" value="NlpE_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043176">
        <property type="entry name" value="NlpE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04170">
        <property type="entry name" value="NlpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17185">
        <property type="entry name" value="NlpE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221144" evidence="1">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="NlpE_C" evidence="2">
        <location>
            <begin position="144"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="236" mass="25816" checksum="0AA39569EA1531D9" modified="2005-12-06" version="1">MVKKAIVTAMAVISLFTLMGCNNRAEVDTLSPAQAAELKPMPQSWRGVLPCADCEGIETSLFLEKDGTWVMNERYLGAREEPSSFASYGTWARTADKLVLTDSKGEKSYYRAKGDALEMLDREGNPIESQFNYTLEPAQSSLPMTPMTLRGMYFYMADAATFTDCATGKRFMVANNAELERGYLAARGNSEKPVLLSVEGHFTLEANPDTGAPTKVLAPDTAGKFYPNKDCSSLGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JR8</accession>
    <name>YAEP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0253 protein YaeP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yaeP</name>
        <name type="ordered locus">SDY_0208</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0253 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60439" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60439.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000417058.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401928.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JR8"/>
    <dbReference type="SMR" id="Q32JR8"/>
    <dbReference type="STRING" id="300267.SDY_0208"/>
    <dbReference type="EnsemblBacteria" id="ABB60439">
        <property type="protein sequence ID" value="ABB60439"/>
        <property type="gene ID" value="SDY_0208"/>
    </dbReference>
    <dbReference type="GeneID" id="67416266"/>
    <dbReference type="KEGG" id="sdy:SDY_0208"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.242"/>
    <dbReference type="HOGENOM" id="CLU_190008_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01064">
        <property type="entry name" value="UPF0253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009624">
        <property type="entry name" value="UPF0253"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06786">
        <property type="entry name" value="UPF0253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000277524" description="UPF0253 protein YaeP">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="66" mass="7214" checksum="98AC59C7178E2D9E" modified="2007-02-06" version="2">MEKYCELIRKRYAEIASGDLGYVPDALGCVLKVLNEMAADDALSEAVREKAAYAAANLLVSDYVNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JW1</accession>
    <name>SFSA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sugar fermentation stimulation protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sfsA</name>
        <name type="ordered locus">SDY_0162</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SfsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000396021.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401885.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JW1"/>
    <dbReference type="SMR" id="Q32JW1"/>
    <dbReference type="STRING" id="300267.SDY_0162"/>
    <dbReference type="EnsemblBacteria" id="ABB60396">
        <property type="protein sequence ID" value="ABB60396"/>
        <property type="gene ID" value="SDY_0162"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0162"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.185"/>
    <dbReference type="HOGENOM" id="CLU_052299_2_0_6"/>
    <dbReference type="OMA" id="VTAHCPN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00095">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="PTHR30545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000008033" description="Sugar fermentation stimulation protein A">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00095"/>
        </source>
    </evidence>
    <sequence length="234" mass="26186" checksum="4EA0B7C16A72B49E" modified="2005-12-06" version="1">MEFSPPLQLATLIQRYKRFLADVITPDGRELTLHCPNTGAMTGCATPGDTVWYSTSDNTKRKYPHTWELTQSQSGAFICVNTLWANRLTKEAILNESISELSGYSSLKSEVKYGAERSRIDFMLQADSRPDCYIEVKSVTLAENEQGYFPDAVTERGQKHLRELMSVAAEGQRAVIFFAVLHSAITRFSPARHIDEKYAQLLSEAQQRGVEILAYKAEISAEGMALKKSLPVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JW2</accession>
    <name>Q32JW2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase-binding transcription factor DksA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">dksA</name>
        <name evidence="9" type="ordered locus">SDY_0161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts directly with the RNA polymerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DksA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001155227.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401884.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JW2"/>
    <dbReference type="SMR" id="Q32JW2"/>
    <dbReference type="STRING" id="300267.SDY_0161"/>
    <dbReference type="EnsemblBacteria" id="ABB60395">
        <property type="protein sequence ID" value="ABB60395"/>
        <property type="gene ID" value="SDY_0161"/>
    </dbReference>
    <dbReference type="GeneID" id="60371850"/>
    <dbReference type="GeneID" id="67416218"/>
    <dbReference type="KEGG" id="sdy:SDY_0161"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.184"/>
    <dbReference type="HOGENOM" id="CLU_043144_2_0_6"/>
    <dbReference type="OMA" id="KKGEEYM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00926">
        <property type="entry name" value="DksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012784">
        <property type="entry name" value="DksA_RNA_pol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02420">
        <property type="entry name" value="dksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="8">
        <location>
            <begin position="71"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="7">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="151" mass="17528" checksum="620842DB15E066A9" modified="2005-12-06" version="1">MQEGQNRKTSSLSILAIAGVEPYQEKPGEEYMNEAQLAHFRRILEAWRNQLRDEVDRTVTHMQDEAANFPDPVDRAAQEEEFSLELRNRDRERKLIKKIEKTLKKVEDEDFGYCESCGVEIGIRRLEARPTADLCIDCKTLAEIREKQMAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JY8</accession>
    <name>GUAC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GMP reductase</fullName>
            <ecNumber evidence="1">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="1">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">guaC</name>
        <name type="ordered locus">SDY_0134</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001217371.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401858.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JY8"/>
    <dbReference type="SMR" id="Q32JY8"/>
    <dbReference type="STRING" id="300267.SDY_0134"/>
    <dbReference type="EnsemblBacteria" id="ABB60369">
        <property type="protein sequence ID" value="ABB60369"/>
        <property type="gene ID" value="SDY_0134"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0134"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.152"/>
    <dbReference type="HOGENOM" id="CLU_022552_5_3_6"/>
    <dbReference type="OMA" id="AYKEYFG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000025619" description="GMP reductase">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00596"/>
        </source>
    </evidence>
    <sequence length="347" mass="37398" checksum="B8E5900B0F01CFBE" modified="2005-12-06" version="1">MRIEEDLKLGFKEVLIRPKRSTLKSRSDVELERQFTFKHSGQSWSGVPIIAANMDTVGTFSMASALASFDILTAVHKHYSVEEWQAFINNSSADVLKHVMVSTGTSDADFEKTKQILDLNPALNFVCIDVANGYSEHFVQFVAKAREAWPTKTICAGNVVTGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTTPGDVAKAFGGGADFVMLGGMLAGHEESGGRIVEENGEKFMLFYGMSSESAMKRHVGGVAEYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVGASRLKELTKRTTFIRVQEQENRIFNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K56</accession>
    <name>Q32K56_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FixA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">fixA</name>
        <name evidence="5" type="ordered locus">SDY_0063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for anaerobic carnitine reduction. May bring reductant to CaiA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine metabolism; carnitine metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of FixA and FixB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K56"/>
    <dbReference type="STRING" id="300267.SDY_0063"/>
    <dbReference type="EnsemblBacteria" id="ABB60301">
        <property type="protein sequence ID" value="ABB60301"/>
        <property type="gene ID" value="SDY_0063"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0063"/>
    <dbReference type="HOGENOM" id="CLU_060196_2_2_6"/>
    <dbReference type="OMA" id="ADLNEWD"/>
    <dbReference type="UniPathway" id="UPA00117"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01055">
        <property type="entry name" value="FixA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023463">
        <property type="entry name" value="FixA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="4">
        <location>
            <begin position="34"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="268" mass="28411" checksum="6B279C3A02B6F0F3" modified="2005-12-06" version="1">MNDVSFMISGDAMKIITCYKCVPDEQDIAVNNADGSLDFSKADAKISQYDLNAIEAACQLKQQAAEAQVTALSVGGKALTNAKGRKDVLSRGPDKLIVVIDDQFEQALPQQTASALAAAAQKAGFDLILCGDGSSDLYAQQVGLLVGEILNIPAVNGVSKIISLTADTLTVERELEDETETLSIPLPAVVAVSTDINSPQIPSMKAILGAAKKPVQVWSAADIGFNAEAAWSEQQVAAPKQRERQRIVIEGDGEEQIAAFAENLRKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K82</accession>
    <name>Q32K82_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yadH</name>
        <name evidence="9" type="ordered locus">SDY_0037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000972203.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401764.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K82"/>
    <dbReference type="SMR" id="Q32K82"/>
    <dbReference type="STRING" id="300267.SDY_0037"/>
    <dbReference type="EnsemblBacteria" id="ABB60275">
        <property type="protein sequence ID" value="ABB60275"/>
        <property type="gene ID" value="SDY_0037"/>
    </dbReference>
    <dbReference type="GeneID" id="66671583"/>
    <dbReference type="KEGG" id="sdy:SDY_0037"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.41"/>
    <dbReference type="HOGENOM" id="CLU_039483_3_0_6"/>
    <dbReference type="OMA" id="HSLPPFW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="9"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="256" mass="28516" checksum="2AE10E6CB143F708" modified="2005-12-06" version="1">MMHLYWVALKSIWAKEIHRFMRIWVQTLVPPVITMTLYFIIFGNLIGSRIGDMHGFSYMQFIVPGLIMMSVITNAYANVASSFFGAKFQRNIEELLVAPVPTHVIIAGYVGGGVARGLFVGILVTAISLFFVPFQVHSWVFVALTLVLTAVLFSLAGLLNGVFAKTFDDISLVPTFVLTPLTYLGGVFYSLTLLPPFWQGLSHLNPIVYMISGFRYGFLGINDVPLVTTFGVLVVFIVAFYLICWSLIQRGRGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q326T1</accession>
    <name>Q326T1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IpaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ipaD</name>
        <name evidence="6" type="ordered locus">SDY_P164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Sd197</strain>
            <plasmid evidence="7">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the invasin protein D family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001028028.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406165.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326T1"/>
    <dbReference type="EnsemblBacteria" id="ABB64677">
        <property type="protein sequence ID" value="ABB64677"/>
        <property type="gene ID" value="SDY_P164"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P164"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5723"/>
    <dbReference type="HOGENOM" id="CLU_069613_0_0_6"/>
    <dbReference type="OMA" id="YVVNINM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036708">
        <property type="entry name" value="BipD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009483">
        <property type="entry name" value="IpaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06511">
        <property type="entry name" value="T3SS_TC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140693">
        <property type="entry name" value="SSF140693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02553">
        <property type="entry name" value="SipD_IpaD_SspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="332" mass="36704" checksum="F18FDCE7F856F03D" modified="2005-12-06" version="1">MNITTLTNSISTSSFSPNNTNGSSTETVNSDIKTTTSSHPVSSLTMLNDTLHNIRTTNQALKKDLSQKTLTKTSLEEIALHSSQISMDVNKSAQLLDILSKKEYPINKDARELLHSAPEEAELDGYQMISHRELWDKIAKSINNINEQYLKVYEHAVSSYTQMYQDFSAVLSSLAGWISPGGNDGNSVKLQVNSLKAELTKLKEKYEDKPLYPANNTVSKEQADKWLTELGGTIGTVSRKNGGYVVNINMSPIDNMLKSLNNLGGNGEVVLDNAKYQAWNAGFSAEDETMKNNLQTLVQKYSNANSIFDNLVKVLSSTISSCTDTDKLFLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q326W4</accession>
    <name>Q326W4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hmo</name>
        <name evidence="3" type="ordered locus">SDY_P131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Hha/YmoA/Cnu family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406132.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326W4"/>
    <dbReference type="EnsemblBacteria" id="ABB64644">
        <property type="protein sequence ID" value="ABB64644"/>
        <property type="gene ID" value="SDY_P131"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P131"/>
    <dbReference type="HOGENOM" id="CLU_190629_1_0_6"/>
    <dbReference type="OMA" id="XSERESF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007985">
        <property type="entry name" value="Hemolysn_expr_modulating_HHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036666">
        <property type="entry name" value="HHA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05321">
        <property type="entry name" value="HHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68989">
        <property type="entry name" value="SSF68989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="62" mass="7157" checksum="83E32AA05D511B67" modified="2005-12-06" version="1">MAVSVTAMFISQYAGKIIHKNRDSLSNSERESFNSAADHRLAELITGKLYDRIPKEIWKYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Z5</accession>
    <name>Q326Z5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yacA</name>
        <name evidence="1" type="ordered locus">SDY_P100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000079957.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406101.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Z5"/>
    <dbReference type="EnsemblBacteria" id="ABB64613">
        <property type="protein sequence ID" value="ABB64613"/>
        <property type="gene ID" value="SDY_P100"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P100"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5652"/>
    <dbReference type="HOGENOM" id="CLU_166926_1_0_6"/>
    <dbReference type="OMA" id="FTFRVDE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="89" mass="10127" checksum="7CC730C5B274753D" modified="2005-12-06" version="1">MAQVNMSVRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNSWFRDQVAAGRQQLECGDVLPHDMVESSAAAWRDEMSRKIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q327G7</accession>
    <name>Q327G7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iso-IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_P028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Sd197</strain>
            <plasmid evidence="9">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406029.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327G7"/>
    <dbReference type="EnsemblBacteria" id="ABB64541">
        <property type="protein sequence ID" value="ABB64541"/>
        <property type="gene ID" value="SDY_P028"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P028"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5565"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_0_6"/>
    <dbReference type="OMA" id="AEMAFNG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="10246" checksum="CBE6A78D42EF9DC8" modified="2005-12-06" version="1">MVTVNLHCPRCQSVQVYRHGQNPKGHDRFRCRDCHRVFQLTYCYEARKPGVKNQITEMAFNGAGVRDTARTLKIGINTVIRTLKSSRPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q327K4</accession>
    <name>Q327K4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yjjK</name>
        <name evidence="7" type="synonym">ettA</name>
        <name evidence="10" type="ordered locus">SDY_4652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000046749.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405992.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327K4"/>
    <dbReference type="SMR" id="Q327K4"/>
    <dbReference type="STRING" id="300267.SDY_4652"/>
    <dbReference type="EnsemblBacteria" id="ABB64501">
        <property type="protein sequence ID" value="ABB64501"/>
        <property type="gene ID" value="SDY_4652"/>
    </dbReference>
    <dbReference type="GeneID" id="66671721"/>
    <dbReference type="KEGG" id="sdy:SDY_4652"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5514"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_6"/>
    <dbReference type="OMA" id="ISYKPQY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="324"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Arm" evidence="7">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="PtIM" evidence="7">
        <location>
            <begin position="242"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="555" mass="62443" checksum="444C7A3E2492D978" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q327M6</accession>
    <name>RSMC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase C</fullName>
            <ecNumber evidence="1">2.1.1.172</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m2G1207 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (guanine-N(2)-)-methyltransferase RsmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmC</name>
        <name type="ordered locus">SDY_4630</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42736"/>
            <dbReference type="Rhea" id="RHEA-COMP:10213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10214"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.172"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmC family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.172" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001272330.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405970.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327M6"/>
    <dbReference type="SMR" id="Q327M6"/>
    <dbReference type="STRING" id="300267.SDY_4630"/>
    <dbReference type="EnsemblBacteria" id="ABB64479">
        <property type="protein sequence ID" value="ABB64479"/>
        <property type="gene ID" value="SDY_4630"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4630"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5488"/>
    <dbReference type="HOGENOM" id="CLU_049581_0_1_6"/>
    <dbReference type="OMA" id="RHCQLWQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052914">
        <property type="term" value="F:16S rRNA (guanine(1207)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01862">
        <property type="entry name" value="16SrRNA_methyltr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013675">
        <property type="entry name" value="Mtase_sm_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023543">
        <property type="entry name" value="rRNA_ssu_MeTfrase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08468">
        <property type="entry name" value="MTS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000369786" description="Ribosomal RNA small subunit methyltransferase C">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01862"/>
        </source>
    </evidence>
    <sequence length="343" mass="37625" checksum="81E190CB86E4BAC2" modified="2005-12-06" version="1">MSAFTPASEVLLRHSDDFEQSRILFAGDLQDDLPARLDTAASRAHTQQFHHWQVLSRQMGDNARFSLVATADDVADCDTLIYYWPKNKPEAQFQLMNLLSLLPVGTDIFVVGENRSGVRSAEQMLADYAPLNKVDSARRCGLYFGRLEKQPVFDAEKFWGEYSVDGLTVKTLPGVFSRDGLDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSVAFARHSPKIRLTLCDVSAPAVEASRATLAANGVEGEVFASNVFSEVKGRFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELRIVANAFLPYPDVLDETFGFHEVIAQTGRFKVYRAIMTRQAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q327X7</accession>
    <name>Q327X7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yjcD</name>
        <name evidence="7" type="ordered locus">SDY_4503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000106882.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405869.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327X7"/>
    <dbReference type="STRING" id="300267.SDY_4503"/>
    <dbReference type="EnsemblBacteria" id="ABB64378">
        <property type="protein sequence ID" value="ABB64378"/>
        <property type="gene ID" value="SDY_4503"/>
    </dbReference>
    <dbReference type="GeneID" id="66672020"/>
    <dbReference type="KEGG" id="sdy:SDY_4503"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5319"/>
    <dbReference type="HOGENOM" id="CLU_024508_0_1_6"/>
    <dbReference type="OMA" id="WVLTNLP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="449" mass="45711" checksum="BDBFE2F057E45910" modified="2005-12-06" version="1">MSTPSARTGGSLDAWFKISQRGSTVRQEVVAGLTTFLAMVYSVIVVPGMLGKAGFPPAAVFVATCLVAGLGSIVMGLWANLPLAIGCAISLTAFTAFSLVLGQHISVPVALGAVFLMGVLFTVISATGIRSWILRNLPHGVAHGTGIGIGLFLLLIAANGVGLVIKNPLDGLPVALGDFATFPVIMSLVGLAVIIGLEKLKVPGGILLTIIGISIVGLIFDPNVHFSGVFAMPSLSDENGNSLIGSLDIMGALNPVVLPSVLALVMTAVFDATGTIRAVAGQANLLDKDGQIIDGGKALTTDSMSSVFSGLVGAAPAAVYIESAAGTAAGGKTGLTAITVGVLFLLILFLSPLSYLVPGYATAPALMYVGLLMLSNVAKIDFADFVDAMAGLVTAVFIVLTCNIVTGIMIGFATLVIGRLVSGEWRKLNIGTVVIAVALVTFYAGGWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q328E1</accession>
    <name>Q328E1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yjeQ</name>
        <name evidence="3" type="synonym">rsgA</name>
        <name evidence="7" type="ordered locus">SDY_4431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328E1"/>
    <dbReference type="STRING" id="300267.SDY_4431"/>
    <dbReference type="EnsemblBacteria" id="ABB64314">
        <property type="protein sequence ID" value="ABB64314"/>
        <property type="gene ID" value="SDY_4431"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4431"/>
    <dbReference type="HOGENOM" id="CLU_033617_2_0_6"/>
    <dbReference type="OMA" id="CLVAAYD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="91"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="5">
        <location>
            <begin position="108"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="201"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="337" mass="37654" checksum="12DFF45AC69831A4" modified="2005-12-06" version="1">MNANHQRRLKTSKEKPDYDDNLFGEPDEGIVISRFGMHADVESADGDVHRCNIRRTIRSLVTGDRVVWRPGKPAAEGVNVKGIVEAVHERTSVLTRPDFYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVACETLQIEPIIVLNKIDLLDDEGMAFVNEQMDIYRNIGYRVLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLGLQKEILTNDVSDNSGLGQHTTTAARLYHFPHGGDVIDSPGVREFGLWHLDPEQITQGFVEFHDYLGLCKYRDCKHDTDPGCAIREAVEEGKIAETRFENYHRILESMAQVKTRKNFSDTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q328N4</accession>
    <name>Q328N4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isocitrate lyase</fullName>
            <ecNumber evidence="1">4.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Isocitrase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isocitratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aceA</name>
        <name evidence="9" type="ordered locus">SDY_4328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Can also use Mn(2+) ion.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000857856.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405712.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328N4"/>
    <dbReference type="SMR" id="Q328N4"/>
    <dbReference type="STRING" id="300267.SDY_4328"/>
    <dbReference type="EnsemblBacteria" id="ABB64221">
        <property type="protein sequence ID" value="ABB64221"/>
        <property type="gene ID" value="SDY_4328"/>
    </dbReference>
    <dbReference type="GeneID" id="66672074"/>
    <dbReference type="KEGG" id="sdy:SDY_4328"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5109"/>
    <dbReference type="HOGENOM" id="CLU_019214_2_0_6"/>
    <dbReference type="OMA" id="LEKDWAE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="PTHR21631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="196"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="317"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="434" mass="47522" checksum="F66449CCD1E168E9" modified="2005-12-06" version="1">MKTRTQQIEELQKEWTQPRWEGITRPYSAEDVVKLRGSVNPECTLAQLGAAKMWRLLHGESKKGYINSLGALTGGQALQQAKAGIEAVYLSGWQVAADANLAASMYPDQSLYPANSVPAVVERINNTFRRADQIQWSAGIEPGDPRYVDYFLPIVADAEAGFGGVLNAFELMKAMIEAGAAAVHFEDQLASVKKCGHMGGKVLVPTQEAIQKLVAARLAADVTGVPTLLVARTDADAADLITSDCDPYDSEFITGERTSEGFFRTHAGIEQAISRGLAYAPYADLVWCETSTPDLELARRFAQAIHAKYPGKLLAYNCSPSFNWQKNLDDKTIASFQQQLSDMGYKFQFITLAGIHSMWFNMFDLANAYAQGEGMKHYVEKVQQPEFAAAKDGYTFVSHQQEVGTGYFDKVTTIIQGGTSSVTALTGSTEESQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Q0</accession>
    <name>Q328Q0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjbD</name>
        <name evidence="2" type="ordered locus">SDY_4309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001207638.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405696.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Q0"/>
    <dbReference type="STRING" id="300267.SDY_4309"/>
    <dbReference type="EnsemblBacteria" id="ABB64205">
        <property type="protein sequence ID" value="ABB64205"/>
        <property type="gene ID" value="SDY_4309"/>
    </dbReference>
    <dbReference type="GeneID" id="66672066"/>
    <dbReference type="KEGG" id="sdy:SDY_4309"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5085"/>
    <dbReference type="HOGENOM" id="CLU_166878_1_0_6"/>
    <dbReference type="OMA" id="AYKPDAE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020317">
        <property type="entry name" value="Uncharacterised_YjbD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11656">
        <property type="entry name" value="DUF3811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="10546" checksum="F21D52B1932B88B4" modified="2005-12-06" version="1">MALPRITQKEMTEREQRELKTLLDRARIAHGRVLTNSETNSIKKEYIDKLMVEREAEAKKARQLKKKQAYKPDPEASFSWSANTSTRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q328S7</accession>
    <name>Q328S7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulator of ribonuclease activity B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yjgD</name>
        <name evidence="2" type="synonym">rraB</name>
        <name evidence="5" type="ordered locus">SDY_4277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with the C-terminal region of Rne.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RraB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000002953.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405669.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328S7"/>
    <dbReference type="SMR" id="Q328S7"/>
    <dbReference type="STRING" id="300267.SDY_4277"/>
    <dbReference type="EnsemblBacteria" id="ABB64178">
        <property type="protein sequence ID" value="ABB64178"/>
        <property type="gene ID" value="SDY_4277"/>
    </dbReference>
    <dbReference type="GeneID" id="66671826"/>
    <dbReference type="KEGG" id="sdy:SDY_4277"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5039"/>
    <dbReference type="HOGENOM" id="CLU_128640_0_0_6"/>
    <dbReference type="OMA" id="FCFDAIA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060698">
        <property type="term" value="F:endoribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01888">
        <property type="entry name" value="RraB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016716">
        <property type="entry name" value="RraB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036701">
        <property type="entry name" value="RraB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009671">
        <property type="entry name" value="RraB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06877">
        <property type="entry name" value="RraB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018193">
        <property type="entry name" value="UCP018193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89946">
        <property type="entry name" value="SSF89946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RraB" evidence="4">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="138" mass="15603" checksum="E23D6DBE6547FD0F" modified="2005-12-06" version="1">MANPEQLEEQREETRLIIEELLEDGSDPDALYTIEHHLSADDLETLEKAAVEAFKLGYEVTDPEELEVEDGDIVICCDILSECALNADLIDAQVEQLMTLAEKFDVEYDGWGTYFEDPNGEDGDDEDFVDEDDDGVRH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q329C8</accession>
    <name>YIDE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative transport protein YidE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidE</name>
        <name type="ordered locus">SDY_4171</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB64077" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64077.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001279745.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405568.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329C8"/>
    <dbReference type="STRING" id="300267.SDY_4171"/>
    <dbReference type="EnsemblBacteria" id="ABB64077">
        <property type="protein sequence ID" value="ABB64077"/>
        <property type="gene ID" value="SDY_4171"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4171"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4904"/>
    <dbReference type="HOGENOM" id="CLU_035023_3_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01016">
        <property type="entry name" value="YidE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023018">
        <property type="entry name" value="Transpt_YidE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006512">
        <property type="entry name" value="YidE_YbjL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06826">
        <property type="entry name" value="Asp-Al_Ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01625">
        <property type="entry name" value="YidE_YbjL_dupl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000226894" description="Putative transport protein YidE">
        <location>
            <begin position="1"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal 1" evidence="1">
        <location>
            <begin position="191"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal 2" evidence="1">
        <location>
            <begin position="279"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="553" mass="59036" checksum="677A090009C49545" modified="2006-03-07" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q329E2</accession>
    <name>Q329E2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetolactate synthase</fullName>
            <ecNumber evidence="6">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvN</name>
        <name evidence="10" type="ordered locus">SDY_4154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001181707.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405554.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329E2"/>
    <dbReference type="STRING" id="300267.SDY_4154"/>
    <dbReference type="EnsemblBacteria" id="ABB64063">
        <property type="protein sequence ID" value="ABB64063"/>
        <property type="gene ID" value="SDY_4154"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4154"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4884"/>
    <dbReference type="HOGENOM" id="CLU_165363_0_0_6"/>
    <dbReference type="OMA" id="NEQSRIW"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="96" mass="11132" checksum="1447DD421EC97D16" modified="2005-12-06" version="1">MQNTTHDNVILELTVRNHPGVMTHVCGLFARRAFNVEGILCLPIQDSDKSYIWLLVNDDQRLEQMISQIDKLEDVVKVQRNQSDPTMFNKIAVFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q329M7</accession>
    <name>Q329M7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipopolysaccharide core heptose(I) kinase</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">waaP</name>
        <name evidence="3" type="ordered locus">SDY_4060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS core biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. KdkA/rfaP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405469.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329M7"/>
    <dbReference type="STRING" id="300267.SDY_4060"/>
    <dbReference type="EnsemblBacteria" id="ABB63978">
        <property type="protein sequence ID" value="ABB63978"/>
        <property type="gene ID" value="SDY_4060"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4060"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4776"/>
    <dbReference type="HOGENOM" id="CLU_081267_0_0_6"/>
    <dbReference type="OMA" id="GWGEIFK"/>
    <dbReference type="UniPathway" id="UPA00958"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017172">
        <property type="entry name" value="Lsacc_core_hep_kinase_RfaP"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037318">
        <property type="entry name" value="RfaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037318-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="268" mass="31468" checksum="FE04D6B37776F4B2" modified="2005-12-06" version="1">MVWMVELKEPFATLWRGKDPFEEVKTLQGEVFRELETRRTLRFEMAGKSYFLKWHRGTTLKEIIKNLLSLRMPVLGADREWNAIHRLRDVGVDTMYGVAFGEKGMNPLTRTSFIITEDLTPTISLEDYCADWATNPPDVRVKRMLIKRVATMVRDMHAAGINHRDCYICHFLLHLPFSGKEEELKISVIDLHRAQLRTRVPRRWRDKDLIGLYFSSMNIGLTQRDIWRFMKVYFAAPLKDILKQEQGLLSQAEAKATKIRERTIRKSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q329T6</accession>
    <name>KUP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Low affinity potassium transport system protein kup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Kup system potassium uptake protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kup</name>
        <name type="ordered locus">SDY_4001</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Responsible for the low-affinity transport of potassium into the cell, with the probable concomitant uptake of protons (symport system).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000102298.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405410.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329T6"/>
    <dbReference type="STRING" id="300267.SDY_4001"/>
    <dbReference type="EnsemblBacteria" id="ABB63919">
        <property type="protein sequence ID" value="ABB63919"/>
        <property type="gene ID" value="SDY_4001"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4001"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4713"/>
    <dbReference type="HOGENOM" id="CLU_008142_4_2_6"/>
    <dbReference type="OMA" id="AADQFEI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01522">
        <property type="entry name" value="Kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023051">
        <property type="entry name" value="K+_uptake_low_affin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0769">Symport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000279829" description="Low affinity potassium transport system protein kup">
        <location>
            <begin position="1"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="158"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="358"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="419"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="442"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01522"/>
        </source>
    </evidence>
    <sequence length="624" mass="69573" checksum="5B0DCA3916AEC3C6" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A00</accession>
    <name>Q32A00_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">recQ</name>
        <name evidence="12" type="ordered locus">SDY_3921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405346.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A00"/>
    <dbReference type="STRING" id="300267.SDY_3921"/>
    <dbReference type="EnsemblBacteria" id="ABB63855">
        <property type="protein sequence ID" value="ABB63855"/>
        <property type="gene ID" value="SDY_3921"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3921"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4629"/>
    <dbReference type="HOGENOM" id="CLU_001103_14_3_6"/>
    <dbReference type="OMA" id="HHDIPKS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006293">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01389">
        <property type="entry name" value="recQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="225"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="9">
        <location>
            <begin position="531"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="611" mass="68606" checksum="21F800C372BC1146" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A08</accession>
    <name>Q32A08_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405338.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A08"/>
    <dbReference type="STRING" id="300267.SDY_3913"/>
    <dbReference type="ESTHER" id="shifl-SF3908">
        <property type="family name" value="Dienelactone_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63847">
        <property type="protein sequence ID" value="ABB63847"/>
        <property type="gene ID" value="SDY_3913"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3913"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4621"/>
    <dbReference type="HOGENOM" id="CLU_054590_7_0_6"/>
    <dbReference type="OMA" id="HIKAYVV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="60"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="289" mass="31504" checksum="D65068ED8440A95C" modified="2005-12-06" version="1">MLTIVNIAQHFYKGTENTMATTQQSGFAPAASPLASTIVQTPDDAIVAGFTSIPSQGDNMPAYHARPKQSDGPLPVVIVVQEIFGVHEHIRDICRRLALEGYLAIAPELYFREGDPNDFADIPTLLSGLVAKVPDSQVLADLDHVASWASRNGGDVHRLMITGFCWGGRITWLYAAHNPQLKAAVAWYGKLTGDKSLNSPKQPVDIATDLNAPVLGLYGGQDNSIPQESVETMRQALRAANAKAEIIVYPDAGHAFNADYRPSYHAESAKDGWQRMLEWFKQYGGKTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A37</accession>
    <name>Q32A37_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Der GTPase-activating protein YihI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">yihI</name>
        <name evidence="4" type="ordered locus">SDY_3877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with Der.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YihI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005015593.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405309.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A37"/>
    <dbReference type="STRING" id="300267.SDY_3877"/>
    <dbReference type="EnsemblBacteria" id="ABB63818">
        <property type="protein sequence ID" value="ABB63818"/>
        <property type="gene ID" value="SDY_3877"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3877"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4587"/>
    <dbReference type="HOGENOM" id="CLU_094104_2_0_6"/>
    <dbReference type="OMA" id="ENNECLN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01058">
        <property type="entry name" value="GAP_YihI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007336">
        <property type="entry name" value="YihI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04220">
        <property type="entry name" value="YihI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="168" mass="18970" checksum="EBC27042F578349E" modified="2005-12-06" version="1">MKPSSPSRSKGHAKARRKTREELNQEARDRKRQKKRRGHAPGSRAAGGNTTSGCKGQNAPKDPRIGSKTPIPLGVTEKVTKQHKPKSEKPMLSPQAELELLETDERLDALLERLEAGETLSAEEQSWVDAKLDRIDELMQKLGLSYDDDEEEEEDEKQEDMMRLLRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A63</accession>
    <name>Q32A63_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Formate dehydrogenase iron-sulfur subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">fdoH</name>
        <name evidence="15" type="ordered locus">SDY_3850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12 13">Binds 4 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000331370.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405283.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A63"/>
    <dbReference type="STRING" id="300267.SDY_3850"/>
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<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
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        </source>
    </evidence>
    <sequence length="359" mass="37074" checksum="D0460AF9FA0E8489" modified="2005-12-06" version="1">MNELVQILKNTRQHLMTGVSHMIPFVVSGGILLAVSVMLYGKGAVPDAVADPNLKKLFDIGVAGLTLMVPFLAAYIGYSIAERSALAPCAIGAWVGNSFGAGFFGALIAGIIGGTVVHYLKKIPVHKVLRSVMPIFIIPIVGTLITAGIMMWGLGEPVGALTNSLTQWLQGMQQGSIVMLAVIMGLMLAFDMGGPVNKVAYAFMLICVAQGVYTVVAIAAVGICIPPLGMGLATLIGRKNFSAEERETGKAALVMGCVGVTEGAIPFAAADPLRVIPSIMVGSVCGAVTAALVGAQCYAGWGGLIVLPVVEGKLGYIAAVAVGAVVTAVCVNVLKSLARKNGSSTDEKEDDLDLDFEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AG4</accession>
    <name>Q32AG4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur transfer protein involved in thiamine biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiS</name>
        <name evidence="1" type="ordered locus">SDY_3735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001166243.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405182.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AG4"/>
    <dbReference type="STRING" id="300267.SDY_3735"/>
    <dbReference type="EnsemblBacteria" id="ABB63691">
        <property type="protein sequence ID" value="ABB63691"/>
        <property type="gene ID" value="SDY_3735"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3735"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4427"/>
    <dbReference type="HOGENOM" id="CLU_174611_2_1_6"/>
    <dbReference type="OMA" id="MRILFND"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7425" checksum="6FA2C783D1748B5A" modified="2005-12-06" version="1">MQILFNDQPMQCATGQTVHELLEQLDQRQAGVALAINQQIVPREQWTQHIVQDGDQILLFQVIAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AH3</accession>
    <name>Q32AH3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein HU-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hupA</name>
        <name evidence="4" type="ordered locus">SDY_3726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001044513.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405173.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AH3"/>
    <dbReference type="SMR" id="Q32AH3"/>
    <dbReference type="STRING" id="300267.SDY_3726"/>
    <dbReference type="EnsemblBacteria" id="ABB63682">
        <property type="protein sequence ID" value="ABB63682"/>
        <property type="gene ID" value="SDY_3726"/>
    </dbReference>
    <dbReference type="GeneID" id="67415298"/>
    <dbReference type="KEGG" id="sdy:SDY_3726"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4418"/>
    <dbReference type="HOGENOM" id="CLU_105066_3_1_6"/>
    <dbReference type="OMA" id="ISQEKQC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="9535" checksum="6B5B8536FDBD13DC" modified="2005-12-06" version="1">MNKTQLIDVIAEKAELSKTQAKAALESTLAAITESLKEGDAVQLVGFGTFKVNHRAERTGRNPQTGKEIKIAAANVPAFVSGKALKDAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AK3</accession>
    <name>Q32AK3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yrfA</name>
        <name evidence="2" type="ordered locus">SDY_3687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405143.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AK3"/>
    <dbReference type="STRING" id="300267.SDY_3687"/>
    <dbReference type="EnsemblBacteria" id="ABB63652">
        <property type="protein sequence ID" value="ABB63652"/>
        <property type="gene ID" value="SDY_3687"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3687"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4374"/>
    <dbReference type="HOGENOM" id="CLU_128670_0_0_6"/>
    <dbReference type="OMA" id="QWRYQGI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019684">
        <property type="entry name" value="HofP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10748">
        <property type="entry name" value="HofP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="147" mass="16899" checksum="6C1917897808C592" modified="2005-12-06" version="1">MMIFCSRYNWRRRMRVKRWLLAGIALCLLTGMRDPFKPPEDLCRISELSQWRYQGMVGRGERIIGVIKDGQKKWRRVQQNDVLENGWTILQLTPDVLTLGTGTNCEPPQWLWQRQGDTNEAMDSRTTVDADTRRTGGKAAKSDADGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AS0</accession>
    <name>Q32AS0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ftsE</name>
        <name evidence="9" type="ordered locus">SDY_3614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000617723.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405076.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AS0"/>
    <dbReference type="SMR" id="Q32AS0"/>
    <dbReference type="STRING" id="300267.SDY_3614"/>
    <dbReference type="EnsemblBacteria" id="ABB63585">
        <property type="protein sequence ID" value="ABB63585"/>
        <property type="gene ID" value="SDY_3614"/>
    </dbReference>
    <dbReference type="GeneID" id="67417092"/>
    <dbReference type="KEGG" id="sdy:SDY_3614"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4290"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="PTRGHID"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="222" mass="24439" checksum="13CFCDECD8FE7590" modified="2005-12-06" version="1">MIRFEHVSKAYLGGRQALQGVTFHMQPGEMAFLTGHSGAGKSTLLKLICGIERPSAGKIWFSGHDITRLKNREVPFLRRQIGMIFQDHHLLMDRTVYDNVAIPLIIAGASGDDIRRRVSAALDKVGLLDKAKNFPIQLSGGEQQRVGIARAVVNKPAVLLADEPTGNLDDALSEGILRLFEEFNRVGVTVLMATHDINLISRRSYRMLTLSDGHLHGGVGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AT1</accession>
    <name>Q32AT1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">High-affinity branched-chain amino acid transport ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">livF</name>
        <name evidence="6" type="ordered locus">SDY_3603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AT1"/>
    <dbReference type="STRING" id="300267.SDY_3603"/>
    <dbReference type="EnsemblBacteria" id="ABB63574">
        <property type="protein sequence ID" value="ABB63574"/>
        <property type="gene ID" value="SDY_3603"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3603"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_6"/>
    <dbReference type="OMA" id="IMMQKIM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR039137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="241" mass="26806" checksum="A4DF406A692D8F0A" modified="2005-12-06" version="1">MRHKMEKVMLSFDKVSAHYGKIQALHEVSLHINQGEIVTLIGANGAGKTTLLGTLCGDPRATSGRIVFDDKDITDWQTAKIMREAVAIVPEGRRVFSRMTVEENLAMGGFFAERDQFQERIKWVYELFPRLHERRVQRAGTMSGGEQQMLAIGLALMSNPRLLLLDEPSLGLAPIIIQQIFDTIEQLREQGMTIFLVEQNANQALKLADRGYVLENGHVVLSDTGDALLANEAVRSAYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AW7</accession>
    <name>Q32AW7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">prlC</name>
        <name evidence="12" type="ordered locus">SDY_3564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019030.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405029.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AW7"/>
    <dbReference type="STRING" id="300267.SDY_3564"/>
    <dbReference type="MEROPS" id="M03.004"/>
    <dbReference type="EnsemblBacteria" id="ABB63538">
        <property type="protein sequence ID" value="ABB63538"/>
        <property type="gene ID" value="SDY_3564"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3564"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4231"/>
    <dbReference type="HOGENOM" id="CLU_001805_4_1_6"/>
    <dbReference type="OMA" id="KNFQSAM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TOP_N" evidence="11">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="10">
        <location>
            <begin position="222"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="680" mass="77311" checksum="B7D379758BD4722D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B08</accession>
    <name>Q32B08_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FUSC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhfK</name>
        <name evidence="3" type="ordered locus">SDY_3520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018973.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404988.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B08"/>
    <dbReference type="STRING" id="300267.SDY_3520"/>
    <dbReference type="EnsemblBacteria" id="ABB63497">
        <property type="protein sequence ID" value="ABB63497"/>
        <property type="gene ID" value="SDY_3520"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3520"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4175"/>
    <dbReference type="HOGENOM" id="CLU_025192_0_0_6"/>
    <dbReference type="OMA" id="MRLWVTH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010020">
        <property type="entry name" value="Integral_membrane_YCCS_YHJK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032692">
        <property type="entry name" value="YccS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12805">
        <property type="entry name" value="FUSC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01667">
        <property type="entry name" value="YCCS_YHJK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="FUSC-like" evidence="2">
        <location>
            <begin position="63"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="696" mass="79511" checksum="6F5732A87A69D688" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B27</accession>
    <name>EFTU_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor Tu</fullName>
            <shortName evidence="2">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuf1</name>
        <name type="synonym">tufA</name>
        <name type="ordered locus">SDY_3500</name>
    </gene>
    <gene>
        <name evidence="2" type="primary">tuf2</name>
        <name type="synonym">tufB</name>
        <name type="ordered locus">SDY_3748</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000031783.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404969.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405194.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B27"/>
    <dbReference type="SMR" id="Q32B27"/>
    <dbReference type="STRING" id="300267.SDY_3500"/>
    <dbReference type="EnsemblBacteria" id="ABB63478">
        <property type="protein sequence ID" value="ABB63478"/>
        <property type="gene ID" value="SDY_3500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63703">
        <property type="protein sequence ID" value="ABB63703"/>
        <property type="gene ID" value="SDY_3748"/>
    </dbReference>
    <dbReference type="GeneID" id="66672781"/>
    <dbReference type="KEGG" id="sdy:SDY_3500"/>
    <dbReference type="KEGG" id="sdy:SDY_3748"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4154"/>
    <dbReference type="HOGENOM" id="CLU_007265_0_2_6"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000337539" description="Elongation factor Tu">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <sequence length="394" mass="43284" checksum="731A60255F43358F" modified="2005-12-06" version="1">MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B42</accession>
    <name>RL24_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplX</name>
        <name type="ordered locus">SDY_3485</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000729181.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404954.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B42"/>
    <dbReference type="SMR" id="Q32B42"/>
    <dbReference type="STRING" id="300267.SDY_3485"/>
    <dbReference type="EnsemblBacteria" id="ABB63463">
        <property type="protein sequence ID" value="ABB63463"/>
        <property type="gene ID" value="SDY_3485"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3485"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4138"/>
    <dbReference type="HOGENOM" id="CLU_093315_2_2_6"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000241661" description="50S ribosomal protein L24">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <sequence length="104" mass="11290" checksum="1BAE7DC214FA07F5" modified="2005-12-06" version="1">MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKAVPALNQPGGIVEKEAAIQVSNVAIFNAATGKADRVGFRFEDGKKVRFFKSNSETIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B78</accession>
    <name>Q32B78_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase B</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">yhdG</name>
        <name evidence="10" type="synonym">dusB</name>
        <name evidence="14" type="ordered locus">SDY_3437</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10 11">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Dus family. DusB subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001219652.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404918.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B78"/>
    <dbReference type="SMR" id="Q32B78"/>
    <dbReference type="STRING" id="300267.SDY_3437"/>
    <dbReference type="EnsemblBacteria" id="ABB63427">
        <property type="protein sequence ID" value="ABB63427"/>
        <property type="gene ID" value="SDY_3437"/>
    </dbReference>
    <dbReference type="GeneID" id="67415907"/>
    <dbReference type="KEGG" id="sdy:SDY_3437"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4093"/>
    <dbReference type="HOGENOM" id="CLU_013299_0_1_6"/>
    <dbReference type="OMA" id="RPWLFAD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02042">
        <property type="entry name" value="DusB_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032887">
        <property type="entry name" value="DusB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Dus" evidence="13">
        <location>
            <begin position="14"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB63427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="321" mass="35866" checksum="B9A31AB459825DE5" modified="2005-12-06" version="1">MRIGQYQLRNRLIAAPMAGITDRPFRTLCYEMGAGLTVSEMMSSNPQVWESDKSRLRMVHIDEPGIRTVQIAGSDPKEMADAARINVESGAQIIDINMGCPAKKVNRKLAGSALLQYPDVVKSILTEVVNAVDVPVTLKIRTGWAPEHRNCEEIAQLAEDCGIQALTIHGRTRACLFNGEAEYDSIRAVKQKVSIPVIANGDITDPLKARAVLDYTGADALMIGRAAQGRPWIFREIQHYLDTGELLPPLPLAEVKRLLCAHVRELHDFYGPAKGYRIARKHVSWYLQEHAPNDQFRRTFNAIEDASEQLEALEAYFENFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BE0</accession>
    <name>Q32BE0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yrbD</name>
        <name evidence="3" type="ordered locus">SDY_3374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018829.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404856.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BE0"/>
    <dbReference type="STRING" id="300267.SDY_3374"/>
    <dbReference type="EnsemblBacteria" id="ABB63365">
        <property type="protein sequence ID" value="ABB63365"/>
        <property type="gene ID" value="SDY_3374"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3374"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4028"/>
    <dbReference type="HOGENOM" id="CLU_107027_0_0_6"/>
    <dbReference type="OMA" id="QYQFPKD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030970">
        <property type="entry name" value="ABC_MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04430">
        <property type="entry name" value="OM_asym_MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="183" mass="19606" checksum="6BD8B922116AFD28" modified="2005-12-06" version="1">MQTKKNEIWVGIFLLAALLAALFVCLKAANVTSIRTEPTYTLYATFDNIGGLKARSPVSIGGVVVGRVADITLDPKTYLPRVTLEIEQRYNHIPDTSSLSIRTSGLLGEQYLALNVGFEDPELGTAILKDGDTIQDTKSAMVLEDLIGQFLYGSKGDDNKNSGDAPAAAPSNNETTEPVGTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BF8</accession>
    <name>Q32BF8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">secG</name>
        <name evidence="12" type="ordered locus">SDY_3356</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018811.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404838.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BF8"/>
    <dbReference type="STRING" id="300267.SDY_3356"/>
    <dbReference type="EnsemblBacteria" id="ABB63347">
        <property type="protein sequence ID" value="ABB63347"/>
        <property type="gene ID" value="SDY_3356"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3356"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4010"/>
    <dbReference type="HOGENOM" id="CLU_094156_2_2_6"/>
    <dbReference type="OMA" id="MYEVLMV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="110" mass="11378" checksum="15F2057A04CDC031" modified="2005-12-06" version="1">MYEALLVVFLIVAIGLIGLIMLQQGKGADMGASFGAGASATLFGSSGSGNFMTRMTALLATLFFIISLVLGNINSNKTNKGSEWKNLSAPAKTEQTQPAAPAKPTSDIPN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BG7</accession>
    <name>TRUB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="1">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truB</name>
        <name type="ordered locus">SDY_3345</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000089690.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404829.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BG7"/>
    <dbReference type="SMR" id="Q32BG7"/>
    <dbReference type="STRING" id="300267.SDY_3345"/>
    <dbReference type="EnsemblBacteria" id="ABB63338">
        <property type="protein sequence ID" value="ABB63338"/>
        <property type="gene ID" value="SDY_3345"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3345"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3999"/>
    <dbReference type="HOGENOM" id="CLU_032087_0_3_6"/>
    <dbReference type="OMA" id="ELQFIRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015240">
        <property type="entry name" value="tRNA_sdUridine_synth_fam1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09157">
        <property type="entry name" value="TruB-C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000229382" description="tRNA pseudouridine synthase B">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <sequence length="314" mass="35044" checksum="05C9DAD256338A15" modified="2005-12-06" version="1">MSRPRRRGRDINGVLLLDKPQGMSSNDALQKVKRIYNANRAGHTGALDPLATGMLPICLGEATKFSQYLLDSDKLYRVIARLGQRTDTSDADGQIVEERPVTFSAEQLAAALDTFRGDIEQIPSMYSALKYQGKKLYEYARQGIEVPREARPITVYELLFIRHEGNELELEIHCSKGTYIRTIIDDLGEKLGCGAHVIYLRRLAVSKYPVERMVTLEHLRELVEQAEQQDIPAAELLDPLLMPMDSPASDYPVVNLPLTSSVYFKNGNPVRTSGAPLEGLVRVTEGENGKFIGMGEIDDEGRVAPRRLVVEYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BK2</accession>
    <name>Q32BK2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Propionate kinase</fullName>
            <ecNumber evidence="5">2.7.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">tdcD</name>
        <name evidence="6" type="ordered locus">SDY_3307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + propanoate = ADP + propanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:23148"/>
            <dbReference type="ChEBI" id="CHEBI:17272"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58933"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family. TdcD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.15" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404794.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BK2"/>
    <dbReference type="STRING" id="300267.SDY_3307"/>
    <dbReference type="EnsemblBacteria" id="ABB63303">
        <property type="protein sequence ID" value="ABB63303"/>
        <property type="gene ID" value="SDY_3307"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3307"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3953"/>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_6"/>
    <dbReference type="OMA" id="IHYLYSI"/>
    <dbReference type="UniPathway" id="UPA00052">
        <property type="reaction ID" value="UER00510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008980">
        <property type="term" value="F:propionate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070689">
        <property type="term" value="P:L-threonine catabolic process to propionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01881">
        <property type="entry name" value="Propion_kin_subfam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024917">
        <property type="entry name" value="Propionate_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF17">
        <property type="entry name" value="PTHR21060:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="282"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="330"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="406" mass="43941" checksum="107802FFE1BFFB03" modified="2005-12-06" version="1">MRKEMNEFPVVLVINCGSSSIKFSVLDASDCEVLMSGIADGINSENAFLSVNGGEPAPLAHHSYEGALKAIAFELEKRNLNDSVALIGHRIAHGGSIFTESAIITDEVIDNIRRVSPLAPLHNYANLSGIESAQQLFPGVTQVAVFDTSFHQTMAPEAYLYGLPWKYYEELGVRRYGFHGTSHRYVSQRAHSLLNLAEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDVDFGAMSWVASQTNQSLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHAASLRRLDGIIFTGGIGENSSLIRRLVIEHLAVLGVEIDTEMNNRSNSFGERIVSSENARVICAVIPTNEEKMIALDAIHLGKVNAPAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BN6</accession>
    <name>Q32BN6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BN6"/>
    <dbReference type="EnsemblBacteria" id="ABB63269">
        <property type="protein sequence ID" value="ABB63269"/>
        <property type="gene ID" value="SDY_3269"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3269"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7582" checksum="52B36A200C829F10" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITVILNERGEVDFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BQ0</accession>
    <name>Q32BQ0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor RpoD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sigma-70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpoD</name>
        <name evidence="10" type="ordered locus">SDY_3251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000437383.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404746.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BQ0"/>
    <dbReference type="STRING" id="300267.SDY_3251"/>
    <dbReference type="EnsemblBacteria" id="ABB63255">
        <property type="protein sequence ID" value="ABB63255"/>
        <property type="gene ID" value="SDY_3251"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3251"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3886"/>
    <dbReference type="HOGENOM" id="CLU_014793_7_2_6"/>
    <dbReference type="OMA" id="RDAKKEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007631">
        <property type="entry name" value="RNA_pol_sigma_70_non-ess"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04546">
        <property type="entry name" value="Sigma70_ner"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="9">
        <location>
            <begin position="572"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="379"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="458"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="547"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="613" mass="70179" checksum="E9C6FE6D45B5CA72" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BT4</accession>
    <name>Q32BT4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Modulator of drug activity B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdaB</name>
        <name evidence="2" type="ordered locus">SDY_3212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000065426.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404712.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BT4"/>
    <dbReference type="STRING" id="300267.SDY_3212"/>
    <dbReference type="EnsemblBacteria" id="ABB63221">
        <property type="protein sequence ID" value="ABB63221"/>
        <property type="gene ID" value="SDY_3212"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3212"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3837"/>
    <dbReference type="HOGENOM" id="CLU_083846_0_0_6"/>
    <dbReference type="OMA" id="DATIWQM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="193" mass="21923" checksum="0EF3A4D13C272FA7" modified="2005-12-06" version="1">MSNILIINGAKKFAHSNGQLNDTLTEVADGTLRDLGHDVRIVRADSDYDVKAEVQNFLWADVVIWQMPGWWMGAPWTVKKYIDDVFTEGHGTLYASDGRTRKDPSKKYGSGGLVQGKKYMLSLTWNAPMEAFTEKDQFFHGVGVDGMYLPFHKANQFLGMEPLPTFIANDVIKMPDVPRYTEEYRKHLVEIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BU9</accession>
    <name>Q32BU9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404697.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BU9"/>
    <dbReference type="STRING" id="300267.SDY_3196"/>
    <dbReference type="EnsemblBacteria" id="ABB63206">
        <property type="protein sequence ID" value="ABB63206"/>
        <property type="gene ID" value="SDY_3196"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3196"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3819"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="CEWALSI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="255" mass="29654" checksum="9E12A9051F33461A" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BX2</accession>
    <name>ZAPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein ZapA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Z ring-associated protein ZapA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">zapA</name>
        <name type="ordered locus">SDY_3171</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Localizes at mid-cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZapA family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001276009.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404674.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BX2"/>
    <dbReference type="SMR" id="Q32BX2"/>
    <dbReference type="STRING" id="300267.SDY_3171"/>
    <dbReference type="EnsemblBacteria" id="ABB63183">
        <property type="protein sequence ID" value="ABB63183"/>
        <property type="gene ID" value="SDY_3171"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3171"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3789"/>
    <dbReference type="HOGENOM" id="CLU_116623_3_0_6"/>
    <dbReference type="OMA" id="NICYELH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02012">
        <property type="entry name" value="ZapA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023771">
        <property type="entry name" value="Cell_div_ZapA_eubact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042233">
        <property type="entry name" value="Cell_div_ZapA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34981">
        <property type="entry name" value="PTHR34981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000345661" description="Cell division protein ZapA">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02012"/>
        </source>
    </evidence>
    <sequence length="109" mass="12622" checksum="26777CC2B1781148" modified="2005-12-06" version="1">MSAQPVDIQIFGRSLRVNCPPDQRDALNQAADDLNQRLQDLKERTRVTNTEQLVFIAALNISYELAQEKAKTRDYAASMEQRIRMLQQTIEQALLERGRITEKTNQNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BZ5</accession>
    <name>Q32BZ5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yggD</name>
        <name evidence="1" type="ordered locus">SDY_3147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000224152.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404651.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BZ5"/>
    <dbReference type="STRING" id="300267.SDY_3147"/>
    <dbReference type="EnsemblBacteria" id="ABB63160">
        <property type="protein sequence ID" value="ABB63160"/>
        <property type="gene ID" value="SDY_3147"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3147"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3759"/>
    <dbReference type="HOGENOM" id="CLU_132701_0_0_6"/>
    <dbReference type="OMA" id="VSKLMFA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007761">
        <property type="entry name" value="MtlR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038026">
        <property type="entry name" value="MtlR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37941">
        <property type="entry name" value="PTHR37941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05068">
        <property type="entry name" value="MtlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158668">
        <property type="entry name" value="SSF158668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="169" mass="19173" checksum="7905E85499ADA175" modified="2005-12-06" version="1">MATLTEDDVLEQLDAQDNLFSFMNTAHSILLQGIRQFLPSLFVDNDEEIVEYAVKPLLAQSGPLDDIDVALRLIYALGKMDKWLYADITHFSQFWHYLNEQDETPGFADDMTWDFISNVNSITCNATLYDALKAMKFADFAVWSEARFSGMVKTALTLVVTTTLKELTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C18</accession>
    <name>YQGF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqgF</name>
        <name type="ordered locus">SDY_3123</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YqgF nuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000017103.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404628.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C18"/>
    <dbReference type="SMR" id="Q32C18"/>
    <dbReference type="STRING" id="300267.SDY_3123"/>
    <dbReference type="EnsemblBacteria" id="ABB63137">
        <property type="protein sequence ID" value="ABB63137"/>
        <property type="gene ID" value="SDY_3123"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3123"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3733"/>
    <dbReference type="HOGENOM" id="CLU_098240_3_0_6"/>
    <dbReference type="OMA" id="PMGWTAQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000257589" description="Putative pre-16S rRNA nuclease">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <sequence length="138" mass="15172" checksum="88A3DD09DA5C1E50" modified="2005-12-06" version="1">MSGTLLAFDFGTKSIGVAVGQRITGTARPLPAIKAQDGTPDWNIIERLLKEWQPDEIIVGLPLNMDGTEQPLTARARKFANRIHGRFGVDVKLHDERLSTVEARSGLFEQGGYRALNKGKVDSASAVIILESYFEQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C75</accession>
    <name>Q32C75_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ARAC-type regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yqhC</name>
        <name evidence="2" type="ordered locus">SDY_3062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404571.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C75"/>
    <dbReference type="STRING" id="300267.SDY_3062"/>
    <dbReference type="EnsemblBacteria" id="ABB63079">
        <property type="protein sequence ID" value="ABB63079"/>
        <property type="gene ID" value="SDY_3062"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3062"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3669"/>
    <dbReference type="HOGENOM" id="CLU_000445_100_2_6"/>
    <dbReference type="OMA" id="LHKARML"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="270"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="375" mass="42550" checksum="3341EC7D42E3721D" modified="2005-12-06" version="1">MRVGVCRLKLFITCSLCWANMRAENDLPDVFHCDRQRPDSQCSFLPMSCLFLQSAGEMLQNCAQSNCRIIPKKLRDMKREEICRLLANKVNKLKNKENSLSELLPDVRLLYGETPFARTPVMYEPGIIILFSGHKIGYINERVFRYDANEYLLLTVPLPFECETYATSEVPLAGLRLNVDILQLQELLMDIGEDEHFQPSMAASGINSATLSEEILCAAERLLDVMERPLDARILGKQIIREILYYVLTGPCGGALLALVSRQTHFSLISRVLKRIENKYTENLSVEQLAAEANMSVSAFHHNFKSVTSTSPLQYLKNYRLHKARMMIIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGEDAARMRAMQGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C90</accession>
    <name>MUTH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein MutH</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Methyl-directed mismatch repair protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mutH</name>
        <name type="ordered locus">SDY_3048</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MutH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000082188.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404556.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C90"/>
    <dbReference type="SMR" id="Q32C90"/>
    <dbReference type="STRING" id="300267.SDY_3048"/>
    <dbReference type="EnsemblBacteria" id="ABB63065">
        <property type="protein sequence ID" value="ABB63065"/>
        <property type="gene ID" value="SDY_3048"/>
    </dbReference>
    <dbReference type="GeneID" id="66673302"/>
    <dbReference type="KEGG" id="sdy:SDY_3048"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3653"/>
    <dbReference type="HOGENOM" id="CLU_086669_0_0_6"/>
    <dbReference type="OMA" id="EVMQLRP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006304">
        <property type="term" value="P:DNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00583">
        <property type="entry name" value="MutH_Sau3AI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00759">
        <property type="entry name" value="MutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004230">
        <property type="entry name" value="DNA_mismatch_repair_MutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011337">
        <property type="entry name" value="DNA_rep_MutH/RE_typeII_Sau3AI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037057">
        <property type="entry name" value="DNA_rep_MutH/T2_RE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02976">
        <property type="entry name" value="MutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00927">
        <property type="entry name" value="MutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02248">
        <property type="entry name" value="mutH_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000046714" description="DNA mismatch repair protein MutH">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00759"/>
        </source>
    </evidence>
    <sequence length="229" mass="25499" checksum="20D2BD945E962CED" modified="2005-12-06" version="1">MSQPRPLLSPPETEEQLLAQAQQLSGYTLGELAALAGLVTPENLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLREDWEELMDMIVLGQVERITARHGEYLQIRPKAANAKALTEAIGARGERILTLPRGFYLKKNFTSALLARHFLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CH6</accession>
    <name>Q32CH6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ygbF</name>
        <name evidence="1" type="ordered locus">SDY_2953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CH6"/>
    <dbReference type="STRING" id="300267.SDY_2953"/>
    <dbReference type="EnsemblBacteria" id="ABB62979">
        <property type="protein sequence ID" value="ABB62979"/>
        <property type="gene ID" value="SDY_2953"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2953"/>
    <dbReference type="HOGENOM" id="CLU_151313_1_0_6"/>
    <dbReference type="OMA" id="TNNEQGF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010152">
        <property type="entry name" value="CRISPR-assoc_prot_Cas2_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09707">
        <property type="entry name" value="Cas_Cas2CT1978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01873">
        <property type="entry name" value="cas_CT1978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="116" mass="13104" checksum="DF2AFA6A0614ED3A" modified="2005-12-06" version="1">MHSLLPFRFLFHWEMQAIGVAEMSMLVVVTENVPPRLRGRLAIWLLEVRAGVYVGDVSAKIREMIWEQIAGLAEEGNVVMAWATNTESGFEFQTFGVNRRTPVDLDGLRLVSFLPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CJ6</accession>
    <name>MUTS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mutS</name>
        <name type="ordered locus">SDY_2933</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001272908.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404450.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CJ6"/>
    <dbReference type="SMR" id="Q32CJ6"/>
    <dbReference type="STRING" id="300267.SDY_2933"/>
    <dbReference type="PRIDE" id="Q32CJ6"/>
    <dbReference type="EnsemblBacteria" id="ABB62959">
        <property type="protein sequence ID" value="ABB62959"/>
        <property type="gene ID" value="SDY_2933"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2933"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3524"/>
    <dbReference type="HOGENOM" id="CLU_002472_4_0_6"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000224404" description="DNA mismatch repair protein MutS">
        <location>
            <begin position="1"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="614"/>
            <end position="621"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <sequence length="853" mass="95319" checksum="663EC55AD139A17C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CN4</accession>
    <name>Q32CN4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CN4"/>
    <dbReference type="STRING" id="300267.SDY_2886"/>
    <dbReference type="EnsemblBacteria" id="ABB62921">
        <property type="protein sequence ID" value="ABB62921"/>
        <property type="gene ID" value="SDY_2886"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2886"/>
    <dbReference type="HOGENOM" id="CLU_125997_1_0_6"/>
    <dbReference type="OMA" id="WSLLFAW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="110" mass="11997" checksum="A37875CA4AB5BF0F" modified="2005-12-06" version="1">MSEALSLFSLFASSFLSATLLPGNSEVVLVAMLLSGISHPWVLVLTATMGNSLGGLTNVILGRFFPLRKTSRWQEKATGWLKRYGAVTLLLSWMPVVGDLLCLLAGWMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CW7</accession>
    <name>Q32CW7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CW7"/>
    <dbReference type="STRING" id="300267.SDY_2795"/>
    <dbReference type="EnsemblBacteria" id="ABB62838">
        <property type="protein sequence ID" value="ABB62838"/>
        <property type="gene ID" value="SDY_2795"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2795"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="87" mass="9668" checksum="499015565D50505E" modified="2005-12-06" version="1">MSRKNQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGTLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D48</accession>
    <name>SYH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="1">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisS</name>
        <name type="ordered locus">SDY_2710</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001107194.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404248.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D48"/>
    <dbReference type="SMR" id="Q32D48"/>
    <dbReference type="STRING" id="300267.SDY_2710"/>
    <dbReference type="EnsemblBacteria" id="ABB62757">
        <property type="protein sequence ID" value="ABB62757"/>
        <property type="gene ID" value="SDY_2710"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2710"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3268"/>
    <dbReference type="HOGENOM" id="CLU_025113_1_1_6"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000016454" description="Histidine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <sequence length="424" mass="47013" checksum="FB58A89AF9C2A76D" modified="2005-12-06" version="1">MAKNIQAIRGMNDYLPSETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQHLWYIGPMFRHERPQKGRYRQFHQLGCEVFGLQGPDIDAELIMLTARWWRALGISEHVTLELNSIGSLEARANYRDALVAFLEQHKEKLDEDCKRRMYTSPLRVLDSKNPEVQALLNDAPALGDYLDEESREHFAGLCKLLESAGIAYTVNQRLVRGLDYYNRTVFEWVTNSLGSQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNPEFKADPVVDIYLVASGADTQSAAMALAERLRDELPGVKLMTNHGGGNFKKQFARADKWGARVAVVLGESEVANGTAVVKDLRSGEQTAVAQDSVAAHLRTLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D92</accession>
    <name>Q32D92_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_2662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D92"/>
    <dbReference type="STRING" id="300267.SDY_2662"/>
    <dbReference type="EnsemblBacteria" id="ABB62713">
        <property type="protein sequence ID" value="ABB62713"/>
        <property type="gene ID" value="SDY_2662"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2662"/>
    <dbReference type="HOGENOM" id="CLU_182070_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="7833" checksum="B0219FAEE5E2EAF2" modified="2005-12-06" version="1">MQQQGVLETGDLEEALNAAQAIGDDRLQQQSQGRVVPDSFTHGTSQQRYSWFKRGFDSGDPAQCNTFGKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DB0</accession>
    <name>Q32DB0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BMC circularly permuted domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_2642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DB0"/>
    <dbReference type="STRING" id="300267.SDY_2642"/>
    <dbReference type="EnsemblBacteria" id="ABB62695">
        <property type="protein sequence ID" value="ABB62695"/>
        <property type="gene ID" value="SDY_2642"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2642"/>
    <dbReference type="HOGENOM" id="CLU_2788664_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044870">
        <property type="entry name" value="BMC_CP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009307">
        <property type="entry name" value="EutS/PduU/CutR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40449">
        <property type="entry name" value="PTHR40449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51931">
        <property type="entry name" value="BMC_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC circularly permuted" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="68" mass="7076" checksum="DD2F8799BB1437A2" modified="2005-12-06" version="1">MTLTPGETAMIAGDLALKAADVHIGFLDRFSGALVIYGSVGAVEEALSQTVSGLGRLLNYTLCEMTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DE9</accession>
    <name>Q32DE9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfeD</name>
        <name evidence="1" type="ordered locus">SDY_2597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000826501.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404147.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DE9"/>
    <dbReference type="STRING" id="300267.SDY_2597"/>
    <dbReference type="EnsemblBacteria" id="ABB62656">
        <property type="protein sequence ID" value="ABB62656"/>
        <property type="gene ID" value="SDY_2597"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2597"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3134"/>
    <dbReference type="HOGENOM" id="CLU_168146_0_0_6"/>
    <dbReference type="OMA" id="LIHIDAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010749">
        <property type="entry name" value="DUF1323"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07037">
        <property type="entry name" value="DUF1323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="130" mass="14901" checksum="6A5BF3931BF04163" modified="2005-12-06" version="1">MKRLRNKMTTEELAECLGVAKQTVNRWIREKGWKTEKFPGVKGGRARLILVDTQVCEFIQNTPAFHNTPMLLEAEEPLAEYAPGIRTPAYRQIISAIDNMTHSEQEKVVQFLSREGIRNFLARLNIDESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DL3</accession>
    <name>Q32DL3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabB</name>
        <name evidence="7" type="ordered locus">SDY_2522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000817192.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404083.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DL3"/>
    <dbReference type="STRING" id="300267.SDY_2522"/>
    <dbReference type="EnsemblBacteria" id="ABB62592">
        <property type="protein sequence ID" value="ABB62592"/>
        <property type="gene ID" value="SDY_2522"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2522"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3037"/>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_6"/>
    <dbReference type="OMA" id="YAYLSMQ"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="406" mass="42629" checksum="43C9E7C199EB243B" modified="2005-12-06" version="1">MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLIDRKVVRFMSDSSIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMQMAMHGVDTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-12-15" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DR0</accession>
    <name>NUOK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoK</name>
        <name type="ordered locus">SDY_2475</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000612644.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404036.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DR0"/>
    <dbReference type="SMR" id="Q32DR0"/>
    <dbReference type="STRING" id="300267.SDY_2475"/>
    <dbReference type="EnsemblBacteria" id="ABB62545">
        <property type="protein sequence ID" value="ABB62545"/>
        <property type="gene ID" value="SDY_2475"/>
    </dbReference>
    <dbReference type="GeneID" id="67516046"/>
    <dbReference type="KEGG" id="sdy:SDY_2475"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2986"/>
    <dbReference type="HOGENOM" id="CLU_144724_0_1_6"/>
    <dbReference type="OMA" id="NFVAFSY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000390238" description="NADH-quinone oxidoreductase subunit K">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <sequence length="100" mass="10845" checksum="CC5AF3946A879383" modified="2005-12-06" version="1">MIPLQHGLILAAILFVLGLTGLVIRRNLLFMLIGLEIMINASALAFVVAGSYWGQTDGQVMYILAISLAAAEASIGLALLLQLHRRRQNLNIDSVSEMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DT6</accession>
    <name>Q32DT6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404010.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DT6"/>
    <dbReference type="EnsemblBacteria" id="ABB62519">
        <property type="protein sequence ID" value="ABB62519"/>
        <property type="gene ID" value="SDY_2448"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2448"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2952"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15333" checksum="F823354A8DFB38D1" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKHLARKTICFSRSVEIHEKVIGMFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DY8</accession>
    <name>Q32DY8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ybjU</name>
        <name evidence="6" type="ordered locus">SDY_2393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000566392.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403958.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DY8"/>
    <dbReference type="STRING" id="300267.SDY_2393"/>
    <dbReference type="EnsemblBacteria" id="ABB62467">
        <property type="protein sequence ID" value="ABB62467"/>
        <property type="gene ID" value="SDY_2393"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2393"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2886"/>
    <dbReference type="HOGENOM" id="CLU_029381_0_3_6"/>
    <dbReference type="OMA" id="NKGGGAC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="333" mass="36514" checksum="35F95D921DCB1C0C" modified="2005-12-06" version="1">MIDLRSDTVTRPSRAMLEAMMAAPVGDDVYGDDPTVNALQDYAAELSGKEAAIFLPTGTQANLVALLSHCERGEEYIVGQAAHNYLFEAGGAAVLGSIQPQPIDAAADGTLPLDKVAMKIKPDDIHFARTKLLSLENTHNGKVLPREYLKEAWKFTRERNLALHVDGARIFNAVMAYGCELKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRAIRWRKMAGGGMRQSGILAAAGMYALKNNVARLKEDHDNAAWMAEQLREAGADVMRQDTNMLFVRVGEENAAALGEYMKARNVLINASPIVRLVTHLDVSREQLAEVAAHWRAFLAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DZ1</accession>
    <name>HCP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydroxylamine reductase</fullName>
            <ecNumber evidence="1">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hybrid-cluster protein</fullName>
            <shortName evidence="1">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hcp</name>
        <name type="ordered locus">SDY_2390</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="1">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HCP family.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DZ1"/>
    <dbReference type="SMR" id="Q32DZ1"/>
    <dbReference type="STRING" id="300267.SDY_2390"/>
    <dbReference type="EnsemblBacteria" id="ABB62464">
        <property type="protein sequence ID" value="ABB62464"/>
        <property type="gene ID" value="SDY_2390"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2390"/>
    <dbReference type="HOGENOM" id="CLU_038344_2_0_6"/>
    <dbReference type="OMA" id="CAYAQGM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01914">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00069">
        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010048">
        <property type="entry name" value="Hydroxylam_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016100">
        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000076">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000009173" description="Hydroxylamine reductase">
        <location>
            <begin position="1"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="1">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <sequence length="552" mass="60334" checksum="308D3ED236A0809E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E32</accession>
    <name>IHFB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integration host factor subunit beta</fullName>
            <shortName evidence="1">IHF-beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ihfB</name>
        <name evidence="1" type="synonym">himD</name>
        <name type="ordered locus">SDY_2346</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000167336.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403914.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E32"/>
    <dbReference type="SMR" id="Q32E32"/>
    <dbReference type="STRING" id="300267.SDY_2346"/>
    <dbReference type="EnsemblBacteria" id="ABB62423">
        <property type="protein sequence ID" value="ABB62423"/>
        <property type="gene ID" value="SDY_2346"/>
    </dbReference>
    <dbReference type="GeneID" id="67414200"/>
    <dbReference type="KEGG" id="sdy:SDY_2346"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2830"/>
    <dbReference type="HOGENOM" id="CLU_105066_2_0_6"/>
    <dbReference type="OMA" id="RDRVNIY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00381">
        <property type="entry name" value="IHF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005685">
        <property type="entry name" value="IHF_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00988">
        <property type="entry name" value="hip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_1000060666" description="Integration host factor subunit beta">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00381"/>
        </source>
    </evidence>
    <sequence length="94" mass="10651" checksum="7558D89EF469EA26" modified="2005-12-06" version="1">MTKSELIERLATQQSHIPAKTVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E36</accession>
    <name>Q32E36_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycaQ</name>
        <name evidence="1" type="ordered locus">SDY_2342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000056533.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403910.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E36"/>
    <dbReference type="STRING" id="300267.SDY_2342"/>
    <dbReference type="EnsemblBacteria" id="ABB62419">
        <property type="protein sequence ID" value="ABB62419"/>
        <property type="gene ID" value="SDY_2342"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2342"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2826"/>
    <dbReference type="HOGENOM" id="CLU_043035_2_0_6"/>
    <dbReference type="OMA" id="FEYWAHE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="410" mass="47618" checksum="837E6E5A82C736CB" modified="2005-12-06" version="1">MSLPHLSLADARNLHLAAQGLLNKPRRRASLEDIPATISRMSLLQIDTINIVARSPYLVLFSRLGNYPAQWLDESLARGELMEYWAHEACFMPRSDFRLIRHRMLAPEKMGWKYKDAWMQEHEAEIAQLIQHIHDKGPVRSADFEHPRKGASGWWEWKPHKRHLEGLFTAGKVMVIERRNFQRVYDLTHRVMPDWDDERDLVSQTEAEIIMLDNSARSLGIFREQWLADYYRLKRPALAAWREARAEQQQIIAVHVEKLGNLWLHADLLPLLERALAGKLTATHSAVLSPFDPVVWDRKRAEQLFDFSYRLECYTPAPKRQYGYFVLPLLHRGQLVGRMDAKMHRQTGILEVISLWLQEGIKPTTTLQKGLRQAITDFANWQQATQVTLGHCPQGLFTDCRTGWEIDPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E68</accession>
    <name>Q32E68_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E68"/>
    <dbReference type="STRING" id="300267.SDY_2310"/>
    <dbReference type="EnsemblBacteria" id="ABB62387">
        <property type="protein sequence ID" value="ABB62387"/>
        <property type="gene ID" value="SDY_2310"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2310"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="MNTNTRN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27557" checksum="28141B28C4FA4239" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELVENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EA6</accession>
    <name>Q32EA6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000846240.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403840.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EA6"/>
    <dbReference type="STRING" id="300267.SDY_2272"/>
    <dbReference type="EnsemblBacteria" id="ABB62349">
        <property type="protein sequence ID" value="ABB62349"/>
        <property type="gene ID" value="SDY_2272"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2272"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2745"/>
    <dbReference type="HOGENOM" id="CLU_024566_3_0_6"/>
    <dbReference type="OMA" id="IPPSWEQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="334" mass="35590" checksum="24B4A72E4170E2C1" modified="2005-12-06" version="1">MKTERILGALYGQALGDAMGMPSELWPRSRVKAHFGWIDRFLPGPKENNAACYFNRAEFTDDTSMALCLADALLEREGKIDPNLIGRNILDWALRFDAFSKNVLGPTSKIALNAIRDGKLVAELENNGVTNGAAMRVSPLGCLLPAHDVDSFIDDVALASSPTHKSDLAVAGAVVIAWAISRAIDGESWSAIVDSLPSIARHAQQKRITTFSASLAARLEIALKIVRNADGTESASEQLYQVVGAGTSTIESVPCAIALVELAQTDPNRCAVLCANLGGDTDTIGAMATAICGALHGVNAIDPALKAELDAVNQLDFNRYATALAKYRQQREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EB6</accession>
    <name>Q32EB6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_U32_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yegQ</name>
        <name evidence="2" type="ordered locus">SDY_2259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000475997.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403830.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EB6"/>
    <dbReference type="STRING" id="300267.SDY_2259"/>
    <dbReference type="MEROPS" id="U32.002"/>
    <dbReference type="EnsemblBacteria" id="ABB62339">
        <property type="protein sequence ID" value="ABB62339"/>
        <property type="gene ID" value="SDY_2259"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2259"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2728"/>
    <dbReference type="HOGENOM" id="CLU_011540_0_2_6"/>
    <dbReference type="OMA" id="YGGVSHF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032525">
        <property type="entry name" value="Peptidase_U32_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16325">
        <property type="entry name" value="Peptidase_U32_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_U32_C" evidence="1">
        <location>
            <begin position="359"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="453" mass="51160" checksum="2A38C44AF4D5B220" modified="2005-12-06" version="1">MFKPELLSPAGTLKNMRYAFAYGADAVYAGQPRYSLRVRNNEFNHENLQLGINEAHALGKKFYVVVNIAPHNAKLKTFIRDLKPVVEMGPDALIMSDPGLIMLVREHFPEMPIHLSVQANAVNWATVKFWQQMGLTRVILSRELSLEEIEEIRHQVPDMEIEIFVHGALCMAYSGRCLLSGYINKRDPNQGTCTNACRWEYNVQEGKEDDVGNIVHKYEPIPVQNVEPTLGIGAPTDKVFMIEEAQRPGEYMTAFEDEHGTYIMNSKDLRAIAHVERLTKMGVHSLKIEGRTKSFYYCARTAQVYRKAIDDAAAGKPFDTSLLETLEGLAHRGYTEGFLRRHTHDDYQNYEYGYSVSDRQQFVGEFTGERKGDLAAVAVKNKFSVGDSLELMTPQGNINFTLEHMENAKGEAMPVALGDGYTVWLPVPQGLELNYALLMRNFSGETTRNPHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EG3</accession>
    <name>Q32EG3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3 7">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rfbC</name>
        <name evidence="8" type="ordered locus">SDY_2207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3 7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001100803.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403783.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EG3"/>
    <dbReference type="STRING" id="300267.SDY_2207"/>
    <dbReference type="EnsemblBacteria" id="ABB62292">
        <property type="protein sequence ID" value="ABB62292"/>
        <property type="gene ID" value="SDY_2207"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2207"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2670"/>
    <dbReference type="HOGENOM" id="CLU_090940_1_1_6"/>
    <dbReference type="OMA" id="RGVFLEW"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="6">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="185" mass="21342" checksum="7DB1E9CD758E8E01" modified="2005-12-06" version="1">MNVIKTEIPDVLIFEPKVFGDERGFFMESFNQKVFEEAVGRKVEFVQDNHSKSTKGVLRGLHYQLEPYAQGKLVRCVVGEVFDVAVDIRKSSPTFGKWIGVNLSAENKRQLWIPEGFAHGFLVLSETAEFVYKTTNYYNPSFEKSISYSDPTIKIQWPNLQDMHFKLSNKDLNAKNFFNNNSLMQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EI8</accession>
    <name>SYM_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="1">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metG</name>
        <name type="ordered locus">SDY_2181</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378786.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403758.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EI8"/>
    <dbReference type="SMR" id="Q32EI8"/>
    <dbReference type="STRING" id="300267.SDY_2181"/>
    <dbReference type="EnsemblBacteria" id="ABB62267">
        <property type="protein sequence ID" value="ABB62267"/>
        <property type="gene ID" value="SDY_2181"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2181"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2637"/>
    <dbReference type="HOGENOM" id="CLU_009710_7_0_6"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000331914" description="Methionine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-binding" evidence="1">
        <location>
            <begin position="575"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="333"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <sequence length="677" mass="76272" checksum="CE8E464300A34296" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EP4</accession>
    <name>Q32EP4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403702.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EP4"/>
    <dbReference type="STRING" id="300267.SDY_2121"/>
    <dbReference type="EnsemblBacteria" id="ABB62211">
        <property type="protein sequence ID" value="ABB62211"/>
        <property type="gene ID" value="SDY_2121"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2121"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2554"/>
    <dbReference type="HOGENOM" id="CLU_027488_0_0_6"/>
    <dbReference type="OMA" id="GWRHRKW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024459">
        <property type="entry name" value="DUF1073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06381">
        <property type="entry name" value="DUF1073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="360" mass="40446" checksum="9438F4C08B2FEA17" modified="2005-12-06" version="1">MTPLRPETIGKGKFKGILPLDRWMVDPALTRRIKDMGPDLGKPEFYDVVTTATGIPARRIHHSRLIRFDGVTLPFQQKMTENEWGMSVVERIWDRLTAFDSATVGAAQLVYKAHLRTYSVEKLRELIALGGPAYEALLKNIDLIRQFQSNEGMTLMDSRDKFETHQYSFSGLDDILSQFAEQISGAVGILLVRLFGQSPKGFSTGDADLANYYDRISSLQERRLRLPVRRILDIMHRSELGKPLPDDFTFEFNPLWQMSDVDRSTVALNTTNAISTALGDGLMTLKAAMTDLRENSDVTGIGASITDEDIENAEDEAPPGIGEPDDEPQELSGGNPVSNQPTQDSEGGWRHRKWSLRWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ER3</accession>
    <name>Q32ER3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ER3"/>
    <dbReference type="EnsemblBacteria" id="ABB62192">
        <property type="protein sequence ID" value="ABB62192"/>
        <property type="gene ID" value="SDY_2101"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2101"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="77" mass="8826" checksum="7FA03C6C66E499D9" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITNCCLRSLLWISFTMFIRYEISHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F48</accession>
    <name>Q32F48_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1949</name>
        <name evidence="4" type="ordered locus">SDY_1956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403541.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403548.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62050">
        <property type="protein sequence ID" value="ABB62050"/>
        <property type="gene ID" value="SDY_1949"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62057">
        <property type="protein sequence ID" value="ABB62057"/>
        <property type="gene ID" value="SDY_1956"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1949"/>
    <dbReference type="KEGG" id="sdy:SDY_1956"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2354"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15352" checksum="425A241FC9E09976" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNISMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F90</accession>
    <name>Q32F90_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ynhG</name>
        <name evidence="10" type="ordered locus">SDY_1909</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000817117.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403506.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F90"/>
    <dbReference type="STRING" id="300267.SDY_1909"/>
    <dbReference type="MEROPS" id="C82.A03"/>
    <dbReference type="EnsemblBacteria" id="ABB62015">
        <property type="protein sequence ID" value="ABB62015"/>
        <property type="gene ID" value="SDY_1909"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1909"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2298"/>
    <dbReference type="HOGENOM" id="CLU_046834_0_0_6"/>
    <dbReference type="OMA" id="LAEYRMY"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041597">
        <property type="entry name" value="Ldt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17969">
        <property type="entry name" value="Ldt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221090" description="LysM domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="9">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="334" mass="36084" checksum="9A4B107F5A19A27F" modified="2005-12-06" version="1">MKRASLLTLTLIGAFSAIQAAWAVDYPLPPTGSRLVGQNQTYTVQEGDKNLQAIARRFDTAAMLILEANNTIAPVPKPGTTITIPSQLLLPDAPRQGIIVNLAELRLYYYPPGENIVQVYPIGIGLQGLETPVMETRVGQKIPNPTWTPTAGIRQRSLERGIKLPPVVPAGPNNPLGRYALRLSHGNGEYLIHGTSAPDSVGLRVSSGCIRMNAPDIKALFSSVRTGTPVKVINEPVKYSVEPNGMRYVEVHRPLSAEEQQNVQTMPYTLPAGFTQFKDNKAVDQKLVDKALYRRAGYPVAVSSGATPTASNAPSVESAQNGEPEQGNMLRATQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FD7</accession>
    <name>PDXY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal kinase PdxY</fullName>
            <shortName evidence="1">PL kinase</shortName>
            <ecNumber evidence="1">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxY</name>
        <name type="ordered locus">SDY_1859</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17310"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family. PdxY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403459.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FD7"/>
    <dbReference type="SMR" id="Q32FD7"/>
    <dbReference type="STRING" id="300267.SDY_1859"/>
    <dbReference type="EnsemblBacteria" id="ABB61968">
        <property type="protein sequence ID" value="ABB61968"/>
        <property type="gene ID" value="SDY_1859"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1859"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2238"/>
    <dbReference type="HOGENOM" id="CLU_046496_3_0_6"/>
    <dbReference type="OMA" id="CPNQLEL"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01639">
        <property type="entry name" value="PdxY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023685">
        <property type="entry name" value="Pyridoxal_kinase_PdxY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PTHR10534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000269831" description="Pyridoxal kinase PdxY">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01639"/>
        </source>
    </evidence>
    <sequence length="287" mass="31348" checksum="4BCDDF7BADC69618" modified="2008-01-15" version="3">MMKNILAIQSHVVYGHAGNSAVEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLTEIVQGIAAIDKLHTCDAVLSGYLGSAEQGEHILGIVRQVKAANPQAKYFCDPVMGHPEKGCIVAPGVAEFHVRHGLPASDIIAPNLVELEILCEHPVNNVEEAVLAARELIAQGPQIVLVKHLAQAGYSRDRFEMLLVTADEAWHISRPLVDFGMRQPVGVGDVTSGLLLVKLLQGATLQEALEHVTAAVYEIMVTTKAMQEYELQVVAAQDRIAKPEHYFSATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FK9</accession>
    <name>Q32FK9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FK9"/>
    <dbReference type="EnsemblBacteria" id="ABB61896">
        <property type="protein sequence ID" value="ABB61896"/>
        <property type="gene ID" value="SDY_1782"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1782"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="9245" checksum="B9297B2409861BF1" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITEEIYSGTTGNYFQRKNRSRARAGCSLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FL7</accession>
    <name>Q32FL7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FL7"/>
    <dbReference type="EnsemblBacteria" id="ABB61888">
        <property type="protein sequence ID" value="ABB61888"/>
        <property type="gene ID" value="SDY_1773"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1773"/>
    <dbReference type="HOGENOM" id="CLU_2452950_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="89" mass="10648" checksum="A2EFBF26C84BF3D4" modified="2005-12-06" version="1">MVTYLRIVNSMKNVENIIWHDGVLVETRMECHHTEYNFILTAELYVDEFTAGRERKRFEFTGVGNDSNLLIVFYVQIMPDDFVMQLHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FP8</accession>
    <name>Q32FP8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FP8"/>
    <dbReference type="EnsemblBacteria" id="ABB61857">
        <property type="protein sequence ID" value="ABB61857"/>
        <property type="gene ID" value="SDY_1739"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1739"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="85" mass="9625" checksum="1D984ED3B2EC4791" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITENSTKSPQRQNAMQNQEGRFQNFFALICKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FU6</accession>
    <name>Q32FU6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ARAC-type regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yeaM</name>
        <name evidence="5" type="ordered locus">SDY_1688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000990348.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403300.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FU6"/>
    <dbReference type="STRING" id="300267.SDY_1688"/>
    <dbReference type="EnsemblBacteria" id="ABB61809">
        <property type="protein sequence ID" value="ABB61809"/>
        <property type="gene ID" value="SDY_1688"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1688"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2035"/>
    <dbReference type="HOGENOM" id="CLU_000445_87_0_6"/>
    <dbReference type="OMA" id="AHRHDDH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="158"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="273" mass="30538" checksum="6126B8686BA685C8" modified="2005-12-06" version="1">MMYRLNLNGYEPDRHHEAAVAFCIHAGTDELTSPVHQHRKGQLILALHGAITCTVENALWMVPPQYAVWIPGGVEHSNQVTANAELCFLFIEPSAVTMPTTCCTLKISPLCRELILTLANRTTTQRAEPMTRRLIQVLFDELPQQPQQQLHLPVSSHPKIRAMVEMMAKEPVEWGSLGQWAGFFAMSERNLARLIVKETGLSFRQWRQQLQLIMALQGLVKGDTVQKVAHTLGYDSTTAFITMFKKGLGQTPGRYIAGLTTVSPQSAKPDPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FU9</accession>
    <name>Q32FU9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yeaK</name>
        <name evidence="2" type="ordered locus">SDY_1685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000138043.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403297.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FU9"/>
    <dbReference type="SMR" id="Q32FU9"/>
    <dbReference type="STRING" id="300267.SDY_1685"/>
    <dbReference type="EnsemblBacteria" id="ABB61806">
        <property type="protein sequence ID" value="ABB61806"/>
        <property type="gene ID" value="SDY_1685"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1685"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2032"/>
    <dbReference type="HOGENOM" id="CLU_094875_2_2_6"/>
    <dbReference type="OMA" id="AKAMLCT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04336">
        <property type="entry name" value="YeaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044786">
        <property type="entry name" value="YeaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="167" mass="17851" checksum="F9B02F76C478174D" modified="2005-12-06" version="1">MTEMAKGSVTHQRLIALLSQEGADFRVVTHEAVGKCEAVSEIRGTALGQGAKALVCKVKGNGVNQHVLAILAADQQADLSQLASHIGGLRASLASPAEVDELTGCVFGAIPPFSFHPKLKLVADPLLFERFDEIAFNAGMLDKSVILKTADYLRIAQPELVNFRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GA1</accession>
    <name>Q32GA1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000781880.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403145.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GA1"/>
    <dbReference type="STRING" id="300267.SDY_1516"/>
    <dbReference type="EnsemblBacteria" id="ABB61654">
        <property type="protein sequence ID" value="ABB61654"/>
        <property type="gene ID" value="SDY_1516"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1516"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1814"/>
    <dbReference type="HOGENOM" id="CLU_037162_19_1_6"/>
    <dbReference type="OMA" id="HADQPGM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="15007" checksum="C91368E45554952D" modified="2005-12-06" version="1">MKMIEVVAAIIERDGKILLAQRPAQSDQAGLWEFAGGKVELDESQQQALVRELNEELGIEATVGEYVASHQREVSGRIIHLHAWHVPDFHGTLQAHEHQALVWCSPEEAQQYPLAPADIPLLEAFMALRAARPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GA3</accession>
    <name>Q32GA3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gdhA</name>
        <name evidence="11" type="ordered locus">SDY_1514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 9">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000373050.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403143.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GA3"/>
    <dbReference type="SMR" id="Q32GA3"/>
    <dbReference type="STRING" id="300267.SDY_1514"/>
    <dbReference type="EnsemblBacteria" id="ABB61652">
        <property type="protein sequence ID" value="ABB61652"/>
        <property type="gene ID" value="SDY_1514"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1514"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1811"/>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_6"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="10">
        <location>
            <begin position="204"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB61652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="447" mass="48569" checksum="05669E2533550C4A" modified="2005-12-06" version="1">MDQTYSLESFLNHVQKRDPNQTEFAQAVREVMTTLWPFLEQNPKYRQMSLLERLVEPERVIQFRVVWVDDRNQVQVNRAWRVQFSSAIGPYKGGMRFHPSVNLSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSEGEVMRFCQALMTELYRHLGADTDVPAGDIGVGGREVGFMAGMMKKLSNNTACVFTGKGLSFGGSLIRPEATGYGLVYFTEAMLKRHGMGFEGMRVSVSGSGNVAQYAIEKAMEFGARVITASDSSGTVVDESGFTKEKLARLIEIKSSRDGRVADYAKEFGLVYLEGQQPWSVPVDIALPCATQNELDVDAAHQLIANGVKAVAEGANMPTTIEATELFQQAGVLFAPGKAANAGGVATSGLEMAQNAARLGWKAEKVDARLHHIMLDIHHACVEHGGEGEQTNYVQGANIAGFVKVADAMLAQGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GF1</accession>
    <name>Q32GF1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DctA-YdbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydbH</name>
        <name evidence="2" type="ordered locus">SDY_1465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000900953.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403095.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GF1"/>
    <dbReference type="STRING" id="300267.SDY_1465"/>
    <dbReference type="EnsemblBacteria" id="ABB61604">
        <property type="protein sequence ID" value="ABB61604"/>
        <property type="gene ID" value="SDY_1465"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1465"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1745"/>
    <dbReference type="HOGENOM" id="CLU_016453_0_0_6"/>
    <dbReference type="OMA" id="ENIFQLW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021730">
        <property type="entry name" value="DctA-YdbH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11739">
        <property type="entry name" value="DctA-YdbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DctA-YdbH" evidence="1">
        <location>
            <begin position="657"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="879" mass="96899" checksum="117A5DC6DE34268D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GJ2</accession>
    <name>Q32GJ2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydaL</name>
        <name evidence="2" type="ordered locus">SDY_1419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001046828.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403054.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GJ2"/>
    <dbReference type="STRING" id="300267.SDY_1419"/>
    <dbReference type="EnsemblBacteria" id="ABB61563">
        <property type="protein sequence ID" value="ABB61563"/>
        <property type="gene ID" value="SDY_1419"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1419"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1689"/>
    <dbReference type="HOGENOM" id="CLU_055978_1_2_6"/>
    <dbReference type="OMA" id="MIKSHVN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="88"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="187" mass="21459" checksum="5FC4ECC116D92129" modified="2005-12-06" version="1">MNLDDKSLFLDAMEDVQPLKRATDVHWHPTRNQRAPQRIDTLQLDNFLTTGFLDIIPLSQPLEFRREGLQHGVLDKLRSGKYPQQASLNLLRQPVEECRKMVFSFIQQALADGLRNVLIIHGKGRDDKSHANIVRSYVARWLTEFDDVQAYCTALPHHGGSGACYVALRKTAQAKQENWERHAKCSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GP4</accession>
    <name>RNB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exoribonuclease 2</fullName>
            <ecNumber evidence="1">3.1.13.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exoribonuclease II</fullName>
            <shortName evidence="1">RNase II</shortName>
            <shortName evidence="1">Ribonuclease II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnb</name>
        <name type="ordered locus">SDY_1366</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family. RNase II subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000484963.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403002.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GP4"/>
    <dbReference type="SMR" id="Q32GP4"/>
    <dbReference type="STRING" id="300267.SDY_1366"/>
    <dbReference type="EnsemblBacteria" id="ABB61511">
        <property type="protein sequence ID" value="ABB61511"/>
        <property type="gene ID" value="SDY_1366"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1366"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1619"/>
    <dbReference type="HOGENOM" id="CLU_002333_7_3_6"/>
    <dbReference type="OMA" id="CFTNYLP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01036">
        <property type="entry name" value="RNase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011804">
        <property type="entry name" value="RNase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02062">
        <property type="entry name" value="RNase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_1000063899" description="Exoribonuclease 2">
        <location>
            <begin position="1"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="561"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01036"/>
        </source>
    </evidence>
    <sequence length="644" mass="72452" checksum="D604EB630AE529EF" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GS9</accession>
    <name>TRPB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="1">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpB</name>
        <name type="ordered locus">SDY_1329</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000209513.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402967.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GS9"/>
    <dbReference type="SMR" id="Q32GS9"/>
    <dbReference type="STRING" id="300267.SDY_1329"/>
    <dbReference type="EnsemblBacteria" id="ABB61476">
        <property type="protein sequence ID" value="ABB61476"/>
        <property type="gene ID" value="SDY_1329"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1329"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1579"/>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_6"/>
    <dbReference type="OMA" id="HGMKSYF"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_1000018397" description="Tryptophan synthase beta chain">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <sequence length="397" mass="42998" checksum="567F435B7AF53612" modified="2005-12-06" version="1">MTTLLNPYFGEFGGMYVPQILMPALRQLEEAFVSAQKDPEFQAQFNDLLKNYAGRPTALTKCQNITAGTNTTLYLKREDLLHGGAHKTNQVLGQALLAKRMGKTEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHSGSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQILEREGRLPDAVIACVGGGSNAIGMFADFINETDVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFGMKAPMMQTEDGQIEESYSISAGLDFPSVGPQHAYLNSTGRADYVSITDDEALEAFKTLCLHEGIIPALESSHALAHALKMMRENPEKEQLLVVNLSGRGDKDIFTVHDILKARGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GZ0</accession>
    <name>Q32GZ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium-calcium/proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">chaA</name>
        <name evidence="7" type="ordered locus">SDY_1266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005023555.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402906.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GZ0"/>
    <dbReference type="STRING" id="300267.SDY_1266"/>
    <dbReference type="EnsemblBacteria" id="ABB61415">
        <property type="protein sequence ID" value="ABB61415"/>
        <property type="gene ID" value="SDY_1266"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1266"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1503"/>
    <dbReference type="HOGENOM" id="CLU_050648_0_0_6"/>
    <dbReference type="OMA" id="AAVMITC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="40"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="224"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="366" mass="39182" checksum="22EB33B618FE9836" modified="2005-12-06" version="1">MSNAQEAVKTRHKETSLIFPVLALVVLFLWGSSQTLPVVIAINLLALIGILSSAFSVVRHADVLAHRLGEPYGSLILSLSVVILEVSLISALMATGDAAPTLMRDTLYSIIMIVTGGLVGFSLLLGGRKFATQYMNLFGIKQYLIALFPLAIIVLVFPMALPAANFSTGQALLVALISAAMYGVFLLIQTKTHQSLFIYEHEDDSDDDDPHHGKPSAHSSLWHAIWLIIHLIAVIAVTKMNASSLETLLDSMNAPVAFTGFLVALLILSPEGLGALKAVLNNQVQRAMNLFFGSVLATISLTVPVVTLIAFMTGNELQFALGAPEMVVMVASLVLCHISFSTGRTNVLNGAAHLALFAAYLMTIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HB9</accession>
    <name>Q32HB9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000896381.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402777.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HB9"/>
    <dbReference type="STRING" id="300267.SDY_1129"/>
    <dbReference type="EnsemblBacteria" id="ABB61286">
        <property type="protein sequence ID" value="ABB61286"/>
        <property type="gene ID" value="SDY_1129"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1129"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1331"/>
    <dbReference type="HOGENOM" id="CLU_030130_8_0_6"/>
    <dbReference type="OMA" id="LWDETGQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="218" mass="24320" checksum="A28F52E9FB5EB890" modified="2005-12-06" version="1">MAFWKVAAAQYEPRKTSLTEQVAHHLEFVRAAARQQCQLLVFPSLSLLGCDYSRRALPAPPDLSLLDPLCYAATTWRMTIIAGLPVEYNAHFIRGIAVFAPWRKTPGIYHQSHGACLGRRSRTITVVDEQPQGMDMDPTCSLFTTGQCLGEPDLLASTRRLQFFSHQYSIAVLMANARGNSALWDEHGRLIVRADRGSLLLVGQRSSQGWQGDIIPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HD1</accession>
    <name>Q32HD1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000082127.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402765.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HD1"/>
    <dbReference type="STRING" id="300267.SDY_1117"/>
    <dbReference type="EnsemblBacteria" id="ABB61274">
        <property type="protein sequence ID" value="ABB61274"/>
        <property type="gene ID" value="SDY_1117"/>
    </dbReference>
    <dbReference type="GeneID" id="66674209"/>
    <dbReference type="KEGG" id="sdy:SDY_1117"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1315"/>
    <dbReference type="HOGENOM" id="CLU_196838_0_0_6"/>
    <dbReference type="OMA" id="RDKMASQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020262">
        <property type="entry name" value="Uncharacterised_YecJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10964">
        <property type="entry name" value="DUF2766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9123" checksum="734060B19BABF6CF" modified="2005-12-06" version="1">MSQPLNADQELVSDVVACQLVIKQILDVLDVIAPVEVREKMSSQLKNIDFTNHPAAADPVTMRAIQKAIALIELKFTPQGESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HS5</accession>
    <name>Q32HS5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yccY</name>
        <name evidence="7" type="ordered locus">SDY_0958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HS5"/>
    <dbReference type="SMR" id="Q32HS5"/>
    <dbReference type="STRING" id="300267.SDY_0958"/>
    <dbReference type="EnsemblBacteria" id="ABB61130">
        <property type="protein sequence ID" value="ABB61130"/>
        <property type="gene ID" value="SDY_0958"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0958"/>
    <dbReference type="HOGENOM" id="CLU_071415_1_1_6"/>
    <dbReference type="OMA" id="AFFPQKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="6">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="152" mass="16833" checksum="5757CD811BC72F15" modified="2005-12-06" version="1">MDSNMAQLKFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLILAMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HT0</accession>
    <name>Q32HT0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable third cytochrome oxidase, subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">appC</name>
        <name evidence="13" type="ordered locus">SDY_0953</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000263588.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402616.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HT0"/>
    <dbReference type="STRING" id="300267.SDY_0953"/>
    <dbReference type="EnsemblBacteria" id="ABB61125">
        <property type="protein sequence ID" value="ABB61125"/>
        <property type="gene ID" value="SDY_0953"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0953"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1101"/>
    <dbReference type="HOGENOM" id="CLU_030555_3_1_6"/>
    <dbReference type="OMA" id="MAIAFWS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB61125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="514" mass="57935" checksum="E07835D55BA23594" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HU2</accession>
    <name>YCCT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0319 protein YccT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yccT</name>
        <name type="ordered locus">SDY_0939</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0319 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000847791.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402604.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HU2"/>
    <dbReference type="STRING" id="300267.SDY_0939"/>
    <dbReference type="EnsemblBacteria" id="ABB61113">
        <property type="protein sequence ID" value="ABB61113"/>
        <property type="gene ID" value="SDY_0939"/>
    </dbReference>
    <dbReference type="GeneID" id="66670760"/>
    <dbReference type="KEGG" id="sdy:SDY_0939"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1087"/>
    <dbReference type="HOGENOM" id="CLU_073782_2_0_6"/>
    <dbReference type="OMA" id="MQIGRDY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00789">
        <property type="entry name" value="UPF0319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018635">
        <property type="entry name" value="UPF0319"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38108">
        <property type="entry name" value="PTHR38108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09829">
        <property type="entry name" value="DUF2057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_1000046908" description="UPF0319 protein YccT">
        <location>
            <begin position="21"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00789"/>
        </source>
    </evidence>
    <sequence length="220" mass="24594" checksum="591A3FA67E0941CA" modified="2005-12-06" version="1" precursor="true">MKTGIVTTLIALCLPVSVFATTLRLSTDVDLLVLDGKKVSSSLLRGADSIELDNGPHQLVFRVEKTIHLSNSEERLYISPPLVVSFNTQLINQVNFRLPRLENEREANHFDAAPRLELLDGDATPIPVKLDILAITSTAKTIDYEVEVERYNKSAKRASLPQFATMMADDSTLLSGVSELDAIPPQSQVLTEQRLKYWFKLADPQTRNTFLQWAEKQPSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I48</accession>
    <name>UVRB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein B</fullName>
            <shortName evidence="1">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrB</name>
        <name type="ordered locus">SDY_0827</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000042529.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402498.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I48"/>
    <dbReference type="SMR" id="Q32I48"/>
    <dbReference type="STRING" id="300267.SDY_0827"/>
    <dbReference type="EnsemblBacteria" id="ABB61009">
        <property type="protein sequence ID" value="ABB61009"/>
        <property type="gene ID" value="SDY_0827"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0827"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.953"/>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_6"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000227360" description="UvrABC system protein B">
        <location>
            <begin position="1"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="431"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="633"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <sequence length="673" mass="76211" checksum="349D08FC344FDAD7" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I58</accession>
    <name>Q32I58_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ybhL</name>
        <name evidence="6" type="ordered locus">SDY_0817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402488.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I58"/>
    <dbReference type="STRING" id="300267.SDY_0817"/>
    <dbReference type="EnsemblBacteria" id="ABB60999">
        <property type="protein sequence ID" value="ABB60999"/>
        <property type="gene ID" value="SDY_0817"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0817"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.941"/>
    <dbReference type="HOGENOM" id="CLU_058671_1_0_6"/>
    <dbReference type="OMA" id="SHNAYAE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="PTHR23291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="184" mass="20425" checksum="B421DF79FDFFF95C" modified="2005-12-06" version="1">MFTNRVFLIGLIIAQLALVIVLSAMIQKLSAGVTTMLFMLYSALTGLTLSSIFIVYTAASIASTFVVTAGMFGAMSLYGYTTKRDLSGFGNMLFMALIGIVLASLVNFWLKSEALMWAVTYIGVIVFVGLTAYDTQKLKNMGEQIDTRDTSNLRKYSILGALTLYLDFINLFLMLLRIFGNRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IC2</accession>
    <name>Q32IC2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative DEOR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_0751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000217875.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402424.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IC2"/>
    <dbReference type="STRING" id="300267.SDY_0751"/>
    <dbReference type="EnsemblBacteria" id="ABB60935">
        <property type="protein sequence ID" value="ABB60935"/>
        <property type="gene ID" value="SDY_0751"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0751"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.865"/>
    <dbReference type="HOGENOM" id="CLU_035309_0_0_6"/>
    <dbReference type="OMA" id="RSPALWM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="13"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="402" mass="41711" checksum="74E4ADF576F91787" modified="2005-12-06" version="1">MTVNSSRNALKRRTWALFMFFFLPGLLMASWATRTPAIRDILSVSIAEMGGVLFGLSIGSMSGILCSAWLVKRFGTRNVILVTMSCALVGMMILSLALWLTSPLLFAVGLGVFGASFGSAEVAINVEGAAVEQEMNKTVLPMMHGFYSLGTLAGAGVGMALTAFGVPATVHILLAALVGIAPIYIAIQAIPDGTGKNAADGTQHGEKGVPFYRDIQLLLIGVVVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTVGRFTGGSFIDRYSRVAVVRASALMGALGIGLIIFVDSAWVAGVSVVLWGLGASLGFPLTISAASDTGPDAPTRVSVVATTGYLAFLVGPPLLGYLGEHYGLRSAMLVVLALVILAAIVAKAVAKPDTKTQTAMENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IE6</accession>
    <name>Q32IE6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402400.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IE6"/>
    <dbReference type="EnsemblBacteria" id="ABB60911">
        <property type="protein sequence ID" value="ABB60911"/>
        <property type="gene ID" value="SDY_0727"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0727"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.841"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="SALICTT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="277" mass="31861" checksum="FF8C90A78A2E8263" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSVSALICTTVSHVKANTLSSTGFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IG2</accession>
    <name>Q32IG2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdate-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">modA</name>
        <name evidence="5" type="ordered locus">SDY_0710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000101990.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402384.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IG2"/>
    <dbReference type="STRING" id="300267.SDY_0710"/>
    <dbReference type="EnsemblBacteria" id="ABB60895">
        <property type="protein sequence ID" value="ABB60895"/>
        <property type="gene ID" value="SDY_0710"/>
    </dbReference>
    <dbReference type="GeneID" id="66670966"/>
    <dbReference type="KEGG" id="sdy:SDY_0710"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.821"/>
    <dbReference type="HOGENOM" id="CLU_065520_3_0_6"/>
    <dbReference type="OMA" id="VCAPQVP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220771" evidence="4">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="257" mass="27410" checksum="2FA3F983E26D946D" modified="2005-12-06" version="1">MARKWLNLFAGAALSFAVAGNALADEGKITVFAAASLTNAMQDIATQYKKEKGVDVVSSFASSSTLARQIEAGAPADLFISADQKWMDYAVDKKAIDTATRQTLLGNSLVVVAPKASEQKDFIIDSKTNWTSLLNGGRLAVGDPEHVPAGIYAKEALQKLGAWDTLSPKLAPAEDVRGALALVERNEAPLGIVYGSDAVASKGVKVVATFPEDSHKKVEYPVAVVEGHNNATVKAFYDYLKGPQAAEIFKRYGFTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IL7</accession>
    <name>Q32IL7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybgO</name>
        <name evidence="2" type="ordered locus">SDY_0651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001209724.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402329.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IL7"/>
    <dbReference type="STRING" id="300267.SDY_0651"/>
    <dbReference type="EnsemblBacteria" id="ABB60840">
        <property type="protein sequence ID" value="ABB60840"/>
        <property type="gene ID" value="SDY_0651"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0651"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.759"/>
    <dbReference type="HOGENOM" id="CLU_064082_2_0_6"/>
    <dbReference type="OMA" id="TTGYCYK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220776" evidence="1">
        <location>
            <begin position="21"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="353" mass="39722" checksum="3FDB9A9C7591A196" modified="2005-12-06" version="1">MRFAKGVLLAICLIFLPLKAALALNCYFGTENGAVEKSEAIMPFAVPANSKPGDKIWESDDIKIPVYCDNNTNGNFESEHVYAWVNPYPGIQDPYYQLGVTYEGVDYDASLGKSRIDTNQCIDSKNIDIYTPEQIIAMGWQNKLCSGDPTVMHKSRTFVARMRLYVKVRAMPPHDYQSKLSDYIVVQFDGAGSVNEDPTAKNLKYHITGLENIRVLDCSVNFAISPETQVVDFGRFNVLDIRRHTMSQQFKITTTKSQNDQCTDGFKVSSSFYTDETLIDEDKSLLIGNGLKLRLLDENASPYTFNKYSEYADFTSDLLVYEKTYTAELSSTPGTPIDVGPFDTVVLFKINYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IM8</accession>
    <name>Q32IM8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IM8"/>
    <dbReference type="STRING" id="300267.SDY_0639"/>
    <dbReference type="EnsemblBacteria" id="ABB60829">
        <property type="protein sequence ID" value="ABB60829"/>
        <property type="gene ID" value="SDY_0639"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0639"/>
    <dbReference type="HOGENOM" id="CLU_046404_5_0_6"/>
    <dbReference type="OMA" id="GNSKYEW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032806">
        <property type="entry name" value="YbfD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13808">
        <property type="entry name" value="DDE_Tnp_1_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1_assoc" evidence="2">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="81"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="167" mass="18577" checksum="F38E58BE408F3DB1" modified="2005-12-06" version="1">MEHKLSDILLLTICAVISGAEGWEDIEDFGETHLDFLKQYGDFENGIPVHDTIARVVSCVSPAKFHECFINWMRDCHSSNDKDVIAIDGKTLRHSYDKSRRKGAIHVISAFSTMHSLVIGQIKTDEKSNEITAIPELLNMLDIKGKIITTDAMGCQKDIAEKGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IQ9</accession>
    <name>Q32IQ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IQ9"/>
    <dbReference type="EnsemblBacteria" id="ABB60798">
        <property type="protein sequence ID" value="ABB60798"/>
        <property type="gene ID" value="SDY_0599"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0599"/>
    <dbReference type="HOGENOM" id="CLU_2685827_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="74" mass="8603" checksum="0F102CFF6F0DF852" modified="2005-12-06" version="1">MSTSHSTLNERRKAKSSPKRAFLMWLGYEDSNLGMPESESGALPLGDTPTNWFLNLPNIFDTFRIWWLRRDSNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J55</accession>
    <name>HEMH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferrochelatase</fullName>
            <ecNumber evidence="1">4.99.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heme synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protoheme ferro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemH</name>
        <name type="ordered locus">SDY_0444</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001250132.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402141.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J55"/>
    <dbReference type="SMR" id="Q32J55"/>
    <dbReference type="STRING" id="300267.SDY_0444"/>
    <dbReference type="EnsemblBacteria" id="ABB60652">
        <property type="protein sequence ID" value="ABB60652"/>
        <property type="gene ID" value="SDY_0444"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0444"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.527"/>
    <dbReference type="HOGENOM" id="CLU_018884_0_0_6"/>
    <dbReference type="OMA" id="LGDPYHC"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0350">Heme biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000019369" description="Ferrochelatase">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <sequence length="320" mass="35870" checksum="584B19DE02FE0582" modified="2005-12-06" version="1">MRQTKTGILLANLGTPDSPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPETPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGREPWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J89</accession>
    <name>Q32J89_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybbN</name>
        <name evidence="2" type="ordered locus">SDY_0407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402107.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J89"/>
    <dbReference type="STRING" id="300267.SDY_0407"/>
    <dbReference type="EnsemblBacteria" id="ABB60618">
        <property type="protein sequence ID" value="ABB60618"/>
        <property type="gene ID" value="SDY_0407"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0407"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.484"/>
    <dbReference type="HOGENOM" id="CLU_046120_1_0_6"/>
    <dbReference type="OMA" id="QPRNMSM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="296" mass="33056" checksum="D523B1C32E78A554" modified="2005-12-06" version="1">MSKKISTTESDSMSVENIVNINESNLQQVLEQSMTTPVLFYFWSERSQHCLQLTPILESLAAQYNGQFILAKLDCDAEQMIAAQFGLRAIPTVYLFQNGQPVDGFQGPQPEEAIRALLDKVLPREEELKAQQAMQLMQEGNYTDALPLLKDAWQLSNQNGEIGLLLAETLIALNRSEDAEAVLKTIPLQDQDTRYQGLVAQIELLKQAADTPEIQQLQQQVAENPEDAALATQLALQLHQVGRNEEALELLFGHLRKDLTAADGQTRKTFQEILAALGTGDALASKYRRQLYALLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J98</accession>
    <name>ALLA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="1">4.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ureidoglycolatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">allA</name>
        <name type="ordered locus">SDY_0397</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-ureidoglycolate = glyoxylate + urea</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; (S)-allantoin degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ureidoglycolate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000776388.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402098.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J98"/>
    <dbReference type="SMR" id="Q32J98"/>
    <dbReference type="STRING" id="300267.SDY_0397"/>
    <dbReference type="EnsemblBacteria" id="ABB60609">
        <property type="protein sequence ID" value="ABB60609"/>
        <property type="gene ID" value="SDY_0397"/>
    </dbReference>
    <dbReference type="GeneID" id="58462776"/>
    <dbReference type="KEGG" id="sdy:SDY_0397"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.471"/>
    <dbReference type="HOGENOM" id="CLU_070848_1_1_6"/>
    <dbReference type="OMA" id="WNIFRCS"/>
    <dbReference type="UniPathway" id="UPA00395"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00616">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023525">
        <property type="entry name" value="Ureidogly_lyase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="PTHR21221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017306">
        <property type="entry name" value="Ureidogly_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0659">Purine metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000061370" description="Ureidoglycolate lyase">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00616"/>
        </source>
    </evidence>
    <sequence length="160" mass="18223" checksum="E39014610FE93FC6" modified="2005-12-06" version="1">MKLQVLPLSQEAFSAYGDVIETQQRDFFHINNGLVERYHDLALVEILEQDRTLISINRAQPANLPLTIHELERHPLGTQAFIPMKGEVFVVVVALGDDKPDLSTLRAFITNGEQGVNYHRNVWHHPLFAWQRVTDFLTIDRGGSDNCDVESIPEQELCFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JA9</accession>
    <name>Q32JA9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mdlA</name>
        <name evidence="10" type="ordered locus">SDY_0385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001235614.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402087.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JA9"/>
    <dbReference type="STRING" id="300267.SDY_0385"/>
    <dbReference type="EnsemblBacteria" id="ABB60598">
        <property type="protein sequence ID" value="ABB60598"/>
        <property type="gene ID" value="SDY_0385"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0385"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.456"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_6_6"/>
    <dbReference type="OMA" id="RVMHDLR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="590" mass="66027" checksum="856D61AEA51968DC" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JE6</accession>
    <name>Q32JE6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000194191.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402050.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JE6"/>
    <dbReference type="EnsemblBacteria" id="ABB60561">
        <property type="protein sequence ID" value="ABB60561"/>
        <property type="gene ID" value="SDY_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0346"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.404"/>
    <dbReference type="HOGENOM" id="CLU_153124_0_0_6"/>
    <dbReference type="OMA" id="PRYWITI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="151" mass="17861" checksum="C4563D349706A6F7" modified="2005-12-06" version="1">MTQRPWSKLQREIYDLLTPTINLQIHCTRYPMRNQNGGSTDLPRYWITLDKNVIWDYPKDFIAGNGGVRNFHGETCWYPYLTDICSISDLLREYIDTPKAEFLTKQFTSDKWGLVNILRAADRRIGMRRLDQLRRKTHNIAALKIIARRSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JS9</accession>
    <name>FABZ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="1">4.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            <shortName evidence="1">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabZ</name>
        <name type="ordered locus">SDY_0196</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">The N-terminus is blocked.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000210739.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401917.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JS9"/>
    <dbReference type="SMR" id="Q32JS9"/>
    <dbReference type="STRING" id="300267.SDY_0196"/>
    <dbReference type="EnsemblBacteria" id="ABB60428">
        <property type="protein sequence ID" value="ABB60428"/>
        <property type="gene ID" value="SDY_0196"/>
    </dbReference>
    <dbReference type="GeneID" id="67416256"/>
    <dbReference type="KEGG" id="sdy:SDY_0196"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.227"/>
    <dbReference type="HOGENOM" id="CLU_078912_1_0_6"/>
    <dbReference type="OMA" id="FPGRPLM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000230836" description="3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <sequence length="151" mass="17033" checksum="91F514A7319C2FB1" modified="2005-12-06" version="1">MTTNTHTLQIEEILELLPHRFPFLLVDRVLDFEEGRFLRAVKNVSVNEPFFQGHFPGKPIFPGVLILEAMAQATGILAFKSVGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVTFEKTRRGLTRFKGVALVDGKVVCEATMMCARSREA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JW9</accession>
    <name>PANB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="1">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">panB</name>
        <name type="ordered locus">SDY_0154</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000805467.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401877.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JW9"/>
    <dbReference type="SMR" id="Q32JW9"/>
    <dbReference type="STRING" id="300267.SDY_0154"/>
    <dbReference type="EnsemblBacteria" id="ABB60388">
        <property type="protein sequence ID" value="ABB60388"/>
        <property type="gene ID" value="SDY_0154"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0154"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.174"/>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_6"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000297376" description="3-methyl-2-oxobutanoate hydroxymethyltransferase">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <sequence length="264" mass="28184" checksum="246A577B8159256E" modified="2005-12-06" version="1">MKPTTIASLQKCKQEKKRFATITAYDYSFAKLFADEGLNVILVGDSLGMTVQGHDSTLPVTVADIAYHTTAVRRGAPNGLLLADLPFMAYATPEQAFENAATVMRAGANMVKIEGGEWLVETVKMLTERAVPVCGHLGLTPQSVNIFGGYKVQGRGDEASDRLLSDALALEAAGAQLLVLECVPVELAKRITEALVIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAETGDIRAAVRQYKAEVESGVYPGEEHSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q326M6</accession>
    <name>Q326M6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein CopB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">repB</name>
        <name evidence="7" type="ordered locus">SDY_P219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Sd197</strain>
            <plasmid evidence="8">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000078111.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406220.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326M6"/>
    <dbReference type="EnsemblBacteria" id="ABB64732">
        <property type="protein sequence ID" value="ABB64732"/>
        <property type="gene ID" value="SDY_P219"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P219"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5773"/>
    <dbReference type="HOGENOM" id="CLU_180887_0_0_6"/>
    <dbReference type="OMA" id="QLQEMCE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006276">
        <property type="term" value="P:plasmid maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019661">
        <property type="entry name" value="RepA2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10723">
        <property type="entry name" value="RepB-RCR_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="1" id="KW-0615">Plasmid copy control</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9780" checksum="F286DEE94794E745" modified="2005-12-06" version="1">MSQIENAVTSSPKRIYRKGNPLTGAEKQRISVSRKKGTHKAINVFIQSELKDDLTQLCKDSGLTQKEMIEHWILKEKAAVDDANRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q326S2</accession>
    <name>Q326S2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IpgF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ipgF</name>
        <name evidence="2" type="ordered locus">SDY_P173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000086107.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406174.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326S2"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64686">
        <property type="protein sequence ID" value="ABB64686"/>
        <property type="gene ID" value="SDY_P173"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P173"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5730"/>
    <dbReference type="HOGENOM" id="CLU_094905_1_0_6"/>
    <dbReference type="OMA" id="HGNTWRA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="1">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="152" mass="17548" checksum="52DF55D6795EFD50" modified="2005-12-06" version="1">MSRFVFILLCFIPHLGRADCWDKAGERYNIPSSLLKAIAEKESGFNKSAVNVNNNGSKDYGIMQINDFHSKRLREMGYTEEMLISHPCLSVHYAAKLLNEFMLMYGRGWEAVGAYNAGTSPKKKKERLKYAEDIYKRYLRIAAESKQNNRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q327I5</accession>
    <name>Q327I5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OspD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ospD2</name>
        <name evidence="2" type="ordered locus">SDY_P010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406011.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327I5"/>
    <dbReference type="EnsemblBacteria" id="ABB64523">
        <property type="protein sequence ID" value="ABB64523"/>
        <property type="gene ID" value="SDY_P010"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P010"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5540"/>
    <dbReference type="HOGENOM" id="CLU_495867_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012927">
        <property type="entry name" value="Toxin_15_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07906">
        <property type="entry name" value="Toxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toxin_15" evidence="1">
        <location>
            <begin position="27"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="572" mass="65285" checksum="E803D456B9EF0F99" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q327K6</accession>
    <name>Q327K6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sms</name>
        <name evidence="5" type="synonym">radA</name>
        <name evidence="8" type="ordered locus">SDY_4650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001029698.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405990.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327K6"/>
    <dbReference type="SMR" id="Q327K6"/>
    <dbReference type="STRING" id="300267.SDY_4650"/>
    <dbReference type="MEROPS" id="S16.A04"/>
    <dbReference type="EnsemblBacteria" id="ABB64499">
        <property type="protein sequence ID" value="ABB64499"/>
        <property type="gene ID" value="SDY_4650"/>
    </dbReference>
    <dbReference type="GeneID" id="67416066"/>
    <dbReference type="KEGG" id="sdy:SDY_4650"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5512"/>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_6"/>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="73"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="357"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="460" mass="49442" checksum="8DE48464827CA455" modified="2005-12-06" version="1">MAKAPKRAFVCNECGADYPRWQGQCSACHAWNTITEVRLAASPTVARNERLSGYAGSAGVAKVQKLSDISLEELPRFSTGFKEFDRVLGGGVVPGSAILIGGNPGAGKSTLLLQTLCKLAQQMKTLYVTGEESLQQVAMRAHRLGLPTDNLNMLSETSIEQICLIAEEEQPKLMVIDSIQVMHMADVQSSPGSVAQVRETAAYLTRFAKTRGVAIVMVGHVTKDGSLAGPKVLEHCIDCSVLLDGDADSRFRTLRSHKNRFGAVNELGVFAMTEQGLREVSNPSAIFLSRGDEVTSGSSVMVVWEGTRPLLVEIQALVDHSMMANPRRVAVGLEQNRLAILLAVLHRHGGLQMADQDVFVNVVGGVKVTETSADLALLLAMVSSLRDRPLPQDLVVFGEVGLAGEIRPVPSGQERISEAAKHGFRRAIVPAANVPKKAPEGMQIFGVKKLSDALSVFDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q327K8</accession>
    <name>Q327K8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">smp</name>
        <name evidence="6" type="ordered locus">SDY_4648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Smp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000090060.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405988.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327K8"/>
    <dbReference type="STRING" id="300267.SDY_4648"/>
    <dbReference type="EnsemblBacteria" id="ABB64497">
        <property type="protein sequence ID" value="ABB64497"/>
        <property type="gene ID" value="SDY_4648"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4648"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5510"/>
    <dbReference type="HOGENOM" id="CLU_093836_0_0_6"/>
    <dbReference type="OMA" id="RQVDNTT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019305">
        <property type="entry name" value="Uncharacterised_Smp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10144">
        <property type="entry name" value="SMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="214" mass="24053" checksum="27F33FFC2A4B9B40" modified="2005-12-06" version="1">MARAKLKFRLHRAVIVLFCLALLVALMQGASWFSQNHQRQRNPQLEELARTLARQVTLNVAPLMRTDSPDEKRIQAILDQLTDESRILDAGVYDEQGDLIARSGESVEVRDRLALDGKKAGGYFNQQIVEPIAGKNGPLGYLRLTLDTHTLATEAQQVDNTTNILRLMLLLSLAIGVVLTRTLLQGKRTRWQQSPFLLTASKPVPEEEESEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q327M7</accession>
    <name>Q327M7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327M7"/>
    <dbReference type="STRING" id="300267.SDY_4626"/>
    <dbReference type="EnsemblBacteria" id="ABB64478">
        <property type="protein sequence ID" value="ABB64478"/>
        <property type="gene ID" value="SDY_4626"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4626"/>
    <dbReference type="HOGENOM" id="CLU_157102_0_0_6"/>
    <dbReference type="OMA" id="SAAMIWH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009885">
        <property type="entry name" value="DUF1435"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07256">
        <property type="entry name" value="DUF1435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="115" mass="12972" checksum="305AD8C29FDD0E67" modified="2005-12-06" version="1">MLILTIGLPDSKGFLWLANDKNYHMILVIIINERDETMLQRTLGSGWGVLLPGLLIAGLMYADLSPDQWRIIILMGLVLTPVMLYHKQLRHYVLLPSCLALIAGIMLMIMNLKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q327U2</accession>
    <name>Q327U2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator LYSR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhjC</name>
        <name evidence="3" type="ordered locus">SDY_4541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405904.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327U2"/>
    <dbReference type="STRING" id="300267.SDY_4541"/>
    <dbReference type="EnsemblBacteria" id="ABB64413">
        <property type="protein sequence ID" value="ABB64413"/>
        <property type="gene ID" value="SDY_4541"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4541"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5369"/>
    <dbReference type="HOGENOM" id="CLU_039613_16_3_6"/>
    <dbReference type="OMA" id="HALIHYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="291" mass="32348" checksum="633A269CD9BB4E71" modified="2005-12-06" version="1">MFIKVAELESFSRAADFFALPKGSVSRQIQALEHQLGTQLLQRTTRRVKLTPEGMTYYQRAKDVLSNLSELDGLFQQDATSISGKLRIDIPPGIAKSLLLPRLSEFLYLHPGIELELSSHDRPVDILHDGFDCVIRTGALPEDGVIARPLGNLTMVNCASPHYLTRFGYPQSPDDLTSHAIVRYTPHLGVHPLGFEVASVNGVQWFKSGGMLTVNSSENYLAAGLAGLGIIQIPRIAVREALRAGRLIEVLPGYRAEPLSLSLVYPQRRELSRRVNLFMQWLAGVMKEYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q327X5</accession>
    <name>Q327X5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulation of superoxide response regulon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">soxS</name>
        <name evidence="3" type="ordered locus">SDY_4505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000019351.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405871.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327X5"/>
    <dbReference type="STRING" id="300267.SDY_4505"/>
    <dbReference type="EnsemblBacteria" id="ABB64380">
        <property type="protein sequence ID" value="ABB64380"/>
        <property type="gene ID" value="SDY_4505"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4505"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5322"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_14_6"/>
    <dbReference type="OMA" id="FTMAWTR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="107" mass="12867" checksum="0336321FBFED1C86" modified="2005-12-06" version="1">MSHQKIIQDLIAWIAEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q327X6</accession>
    <name>Q327X6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Redox-sensitive transcriptional activator SoxR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">soxR</name>
        <name evidence="10" type="ordered locus">SDY_4504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000412428.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405870.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327X6"/>
    <dbReference type="SMR" id="Q327X6"/>
    <dbReference type="STRING" id="300267.SDY_4504"/>
    <dbReference type="EnsemblBacteria" id="ABB64379">
        <property type="protein sequence ID" value="ABB64379"/>
        <property type="gene ID" value="SDY_4504"/>
    </dbReference>
    <dbReference type="GeneID" id="67414700"/>
    <dbReference type="KEGG" id="sdy:SDY_4504"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5321"/>
    <dbReference type="HOGENOM" id="CLU_060077_5_1_6"/>
    <dbReference type="OMA" id="IHFYEAK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01110">
        <property type="entry name" value="HTH_SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010211">
        <property type="entry name" value="Redox-sen_tscrpt-act_SoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30204:SF0">
        <property type="entry name" value="PTHR30204:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01950">
        <property type="entry name" value="SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="9">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="154" mass="17150" checksum="9A715120860EEC9B" modified="2005-12-06" version="1">MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIGEAFGVLPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q328D3</accession>
    <name>Q328D3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjdC</name>
        <name evidence="3" type="ordered locus">SDY_4440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328D3"/>
    <dbReference type="STRING" id="300267.SDY_4440"/>
    <dbReference type="EnsemblBacteria" id="ABB64322">
        <property type="protein sequence ID" value="ABB64322"/>
        <property type="gene ID" value="SDY_4440"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4440"/>
    <dbReference type="HOGENOM" id="CLU_1389758_0_0_6"/>
    <dbReference type="OMA" id="IWRRQLM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="172" mass="19810" checksum="D454D2C2D2E20DCC" modified="2005-12-06" version="1">MGKTEENSVQREDVLGEALKLLELQGIANTTLEMVAERVDYPLDELRRFWPDKEAILYDALRYLSQQIDVWRRQLMLDETQTAEQKLLARYQALSECVKNNRYPGCLFIAACTFYPDPGHPIHQLADQQKSAAYDFTHELLTTLEVDDPAMVAKQMELVLEGCLSRMLVNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q328E7</accession>
    <name>Q328E7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yjeE</name>
        <name evidence="5" type="ordered locus">SDY_4421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000981977.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405799.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328E7"/>
    <dbReference type="SMR" id="Q328E7"/>
    <dbReference type="STRING" id="300267.SDY_4421"/>
    <dbReference type="EnsemblBacteria" id="ABB64308">
        <property type="protein sequence ID" value="ABB64308"/>
        <property type="gene ID" value="SDY_4421"/>
    </dbReference>
    <dbReference type="GeneID" id="60902986"/>
    <dbReference type="KEGG" id="sdy:SDY_4421"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5219"/>
    <dbReference type="HOGENOM" id="CLU_087829_2_2_6"/>
    <dbReference type="OMA" id="FTDDAIC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="153" mass="16853" checksum="49F8C7AA5965EC55" modified="2005-12-06" version="1">MMNRVIPLPDEQATLDLGERVAKACDGATVIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYTLDNLMVYHFDLYRLADPEELEFMGIRDYFANDAICLVEWPQQGTGVLPDPDVEIHIDYQAQGREARVSAVSSAGELLLARLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q328P8</accession>
    <name>Q328P8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator of sorbose uptake and utilization genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_4311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000431652.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405698.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328P8"/>
    <dbReference type="STRING" id="300267.SDY_4311"/>
    <dbReference type="EnsemblBacteria" id="ABB64207">
        <property type="protein sequence ID" value="ABB64207"/>
        <property type="gene ID" value="SDY_4311"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4311"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5087"/>
    <dbReference type="HOGENOM" id="CLU_054506_1_1_6"/>
    <dbReference type="OMA" id="WGPETVA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_38" evidence="3">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="58"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="315" mass="35003" checksum="4797C8D289C13232" modified="2005-12-06" version="1">MENSDDIRLIVKIAQLYYEQDMTQAQIARELGIYRTTISRLLKRGRDQGIVTIAINYDYNENLWLEQQLKQKFGLKDIVVVLGNDEDEETQLAMMGLHGAQLLDRLLEPSDIVGFSWGRAVSALVENLPQAGQSRQLICVPIIGGPSGKLESRYHVNTLTYSAAAKLKGESHLADFPALLDNPLIRNGIMQSQHFKTISAYWDNLDVALVGIGSPAIRDGANWHAFYGGEESDDLNARQVAGDICSRFFDIHGAMVETNMSEKTLSIEMNKLKQARYSIGIAMSEEKYSGTIGALRGKYINCLVTNSSTAELLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q328R7</accession>
    <name>Q328R7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yjgB</name>
        <name evidence="5" type="ordered locus">SDY_4288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405679.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328R7"/>
    <dbReference type="STRING" id="300267.SDY_4288"/>
    <dbReference type="EnsemblBacteria" id="ABB64188">
        <property type="protein sequence ID" value="ABB64188"/>
        <property type="gene ID" value="SDY_4288"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4288"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5055"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_6"/>
    <dbReference type="OMA" id="FARNEHK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="27"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="353" mass="38156" checksum="E9470D0DC8BD62F5" modified="2005-12-06" version="1">MLYTSQTTPEKDQKMSMIKSYAAKEAGGELEVYEYDPGELKPQDVEVQVDYCGICHSDLSMIDNEWGFSQYPLVAGHEVIGRVVALGSAAQDKGLQVGQRVGIGWTARSCGHCDACISGNQINCEQGAVPTIMNRGGFAEKLRADWQWVIPLPENIDIESAGPLLCGGITVFKPLLMHHITATSRVGVIGIGGLGHIAIKLLHAMGCEVTAFSSNPAKEQEVLAMGADKVVNSRDPQALKALAGQFDLIINTVNVSLDWQPYFEALTYGGNFHTVGAVLTPLSVPAFTLIAGDRSVSGSATGTPYELRKLMRFAARSKVAPTTELFPMSKINDTIKHVRDGKARYRVVLKADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q329C5</accession>
    <name>Q329C5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yidQ</name>
        <name evidence="3" type="ordered locus">SDY_4174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329C5"/>
    <dbReference type="STRING" id="300267.SDY_4174"/>
    <dbReference type="EnsemblBacteria" id="ABB64080">
        <property type="protein sequence ID" value="ABB64080"/>
        <property type="gene ID" value="SDY_4174"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4174"/>
    <dbReference type="HOGENOM" id="CLU_129878_0_0_6"/>
    <dbReference type="OMA" id="SSVMTHT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010780">
        <property type="entry name" value="DUF1375"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07119">
        <property type="entry name" value="DUF1375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="14697" checksum="7404FF2D1A78DC01" modified="2005-12-06" version="1">MMMLFSARDRYNSSGQHPRSTDEFIMIRNVLLAFMICSGMALLGGCSSVMSHTGGKEGTYPGTRASATMIGDDETNWGTKSLAILDMPFTAVMDTLLLPWGVFRKDSSVRSRVEKSEANAQATNAVIPPARMPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q329H4</accession>
    <name>Q329H4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphonate metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phnM</name>
        <name evidence="3" type="ordered locus">SDY_4121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000586323.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405522.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329H4"/>
    <dbReference type="STRING" id="300267.SDY_4121"/>
    <dbReference type="EnsemblBacteria" id="ABB64031">
        <property type="protein sequence ID" value="ABB64031"/>
        <property type="gene ID" value="SDY_4121"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4121"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4845"/>
    <dbReference type="HOGENOM" id="CLU_060303_0_0_6"/>
    <dbReference type="OMA" id="MSLMDHT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01306">
        <property type="entry name" value="PhnM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012696">
        <property type="entry name" value="PhnM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038971">
        <property type="entry name" value="PhnM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="2">
        <location>
            <begin position="194"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="350" mass="38862" checksum="5FA2767320E8018D" modified="2005-12-06" version="1">MIINNVKLVLENEVVSGSLEVQDGEIRAFAESQSRLPEAMDGEGGWLLPGLIELHTDNLDKFFTPRPKVDWPAHSAMSSHDALMVASGITTVLDAVAIGDVRDGGDRLENLEKMINAIEETQKRGVNRAEHRLHLRCELPHHTTLPLFEKLVQREPVTLVSLMDHSPGQRQFANREKYREYYQGKYSLTDAQIQQYEEEQLALASHAHVTESHQLGSVIAEFPTTFEAAEASRKHGMNVLMGAPNIVRGGSHSGNVAASELAQLGLLDILSSDYYPASLLDAAFRVADDQSNRFTLPQAVKLVTKNPAQALNLQDRGVIGEGKRADLVLAHRKGNHIHIDHVWRQGKRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q329J0</accession>
    <name>Q329J0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Proline permease II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">proP</name>
        <name evidence="11" type="ordered locus">SDY_4102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001298520.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405506.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329J0"/>
    <dbReference type="SMR" id="Q329J0"/>
    <dbReference type="STRING" id="300267.SDY_4102"/>
    <dbReference type="EnsemblBacteria" id="ABB64015">
        <property type="protein sequence ID" value="ABB64015"/>
        <property type="gene ID" value="SDY_4102"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4102"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4825"/>
    <dbReference type="HOGENOM" id="CLU_001265_39_0_6"/>
    <dbReference type="OMA" id="FLVEMFP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004736">
        <property type="entry name" value="MHS_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015041">
        <property type="entry name" value="Osmo_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036292">
        <property type="entry name" value="ProP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08946">
        <property type="entry name" value="Osmo_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103661">
        <property type="entry name" value="SSF103661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00883">
        <property type="entry name" value="2A0106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="26"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB64015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="500" mass="54846" checksum="60EDDBF61190DDFC" modified="2005-12-06" version="1">MLKRKKVKPITLRDVTIIDDGKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYDTIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQGDREGLQDGPKVSFKEIATKYWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVLLGSVALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESSQNLMMPAYYLMVVAVVGLITGVTMKETANRPLKGATPAASDIQEAKEILVEHYDNIEQKIDDIDHEIADLQAKRTRLVQQHPRIDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q329K8</accession>
    <name>KGUA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gmk</name>
        <name type="ordered locus">SDY_4080</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016672.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405488.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329K8"/>
    <dbReference type="SMR" id="Q329K8"/>
    <dbReference type="STRING" id="300267.SDY_4080"/>
    <dbReference type="EnsemblBacteria" id="ABB63997">
        <property type="protein sequence ID" value="ABB63997"/>
        <property type="gene ID" value="SDY_4080"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4080"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4801"/>
    <dbReference type="HOGENOM" id="CLU_001715_1_0_6"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000266401" description="Guanylate kinase">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <sequence length="207" mass="23651" checksum="63B69F6406365334" modified="2005-12-06" version="1">MAQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSVSHTTRQPRPGEVHGEHYFFVNHDEFKEMISRDAFLEHAEVFDNYYGTSREAIEQVLATGVDVFLDIDWQGAQQIRQKMPHARSIFILPPSKIELDRRLRGRGQDSEEVIAKRMAQAVAEMSHYAEYDYLIVNDDFDTALTDLKTIIRAERLRMSRQKQRHDALISKLLAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q329S0</accession>
    <name>ATPE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpC</name>
        <name type="ordered locus">SDY_4017</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text>F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001251965.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405426.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329S0"/>
    <dbReference type="SMR" id="Q329S0"/>
    <dbReference type="STRING" id="300267.SDY_4017"/>
    <dbReference type="EnsemblBacteria" id="ABB63935">
        <property type="protein sequence ID" value="ABB63935"/>
        <property type="gene ID" value="SDY_4017"/>
    </dbReference>
    <dbReference type="GeneID" id="67417718"/>
    <dbReference type="KEGG" id="sdy:SDY_4017"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4730"/>
    <dbReference type="HOGENOM" id="CLU_084338_2_0_6"/>
    <dbReference type="OMA" id="MGGFAEI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="SSF46604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000265893" description="ATP synthase epsilon chain">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <sequence length="139" mass="15068" checksum="5EFF7DE911745A62" modified="2005-12-06" version="1">MAMTYHLDVVSAEQQMFSGLVEKIQVTGSEGELGIYPGHAPLLTAIKPGMIRIVKQHGHEEFIYLSGGILEVQPGNVTVLADTAIRGQDLDEARAMEAKRKAEEHISSSHGDVDYAQASAELAKAIAQLRVIELTKKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A14</accession>
    <name>Q32A14_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ordered locus">SDY_3907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405332.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A14"/>
    <dbReference type="STRING" id="300267.SDY_3907"/>
    <dbReference type="EnsemblBacteria" id="ABB63841">
        <property type="protein sequence ID" value="ABB63841"/>
        <property type="gene ID" value="SDY_3907"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3907"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4615"/>
    <dbReference type="HOGENOM" id="CLU_086034_5_1_6"/>
    <dbReference type="OMA" id="GGISIWN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="103" mass="11338" checksum="537812862EE436FA" modified="2005-12-06" version="1">MRLCLIIIYHRGTCMGGISIWQLLIIAVIVVLLFGTKKLGSIGSDLGASIKGFKKAMSDDEPKQDKTSQDADFTAKTIADKQADTNQEQAKTEDAKRHDKEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AA8</accession>
    <name>Q32AA8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">priA</name>
        <name evidence="12" type="ordered locus">SDY_3802</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005015808.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405238.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AA8"/>
    <dbReference type="STRING" id="300267.SDY_3802"/>
    <dbReference type="EnsemblBacteria" id="ABB63747">
        <property type="protein sequence ID" value="ABB63747"/>
        <property type="gene ID" value="SDY_3802"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3802"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4492"/>
    <dbReference type="HOGENOM" id="CLU_013353_3_1_6"/>
    <dbReference type="OMA" id="RCHYCGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="211"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="456"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="732" mass="81655" checksum="F2322B4C1469D069" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AK7</accession>
    <name>Q32AK7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AK7"/>
    <dbReference type="STRING" id="300267.SDY_3683"/>
    <dbReference type="EnsemblBacteria" id="ABB63648">
        <property type="protein sequence ID" value="ABB63648"/>
        <property type="gene ID" value="SDY_3683"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3683"/>
    <dbReference type="HOGENOM" id="CLU_2304107_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11738" checksum="F3BE0C1BDAB306E2" modified="2005-12-06" version="1">MAFKIWQIGLHLQQQEAVAVAIVRDAKECFLQRWWRLPLAHDIIKDGRIVDAQRLAKTLLPWSRELPQRHHIMLAFPASRTLQRSFPRPSMSLGEREQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AK9</accession>
    <name>Q32AK9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yrfE</name>
        <name evidence="4" type="ordered locus">SDY_3681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000045740.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405137.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AK9"/>
    <dbReference type="STRING" id="300267.SDY_3681"/>
    <dbReference type="EnsemblBacteria" id="ABB63646">
        <property type="protein sequence ID" value="ABB63646"/>
        <property type="gene ID" value="SDY_3681"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3681"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4368"/>
    <dbReference type="HOGENOM" id="CLU_062658_4_0_6"/>
    <dbReference type="OMA" id="PGYFASK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="186" mass="21167" checksum="D959AD94D573E6DE" modified="2005-12-06" version="1">MSKSLQKPTILNVETVARSRLFTVESVDLEFSNGVRRVYERMRPTNREAVMIVPIVDDHLILIREYAVGTESYELGFSKGLIDPGESVYEAANRELKEEVGFGANDLTFLKKLSMAPSYFSSKMNILVAQDLYPESLEGDEPEPLPQVRWPLAHMMDLLEDPDFNEARNVSALFLVREWLKGQGRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AN7</accession>
    <name>GLPE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiosulfate sulfurtransferase GlpE</fullName>
            <ecNumber evidence="1">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glpE</name>
        <name type="ordered locus">SDY_3650</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GlpE family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000371932.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405109.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AN7"/>
    <dbReference type="SMR" id="Q32AN7"/>
    <dbReference type="STRING" id="300267.SDY_3650"/>
    <dbReference type="EnsemblBacteria" id="ABB63618">
        <property type="protein sequence ID" value="ABB63618"/>
        <property type="gene ID" value="SDY_3650"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3650"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4332"/>
    <dbReference type="HOGENOM" id="CLU_089574_14_0_6"/>
    <dbReference type="OMA" id="VCYHGIS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01444">
        <property type="entry name" value="GlpE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01009">
        <property type="entry name" value="Thiosulf_sulfurtr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023695">
        <property type="entry name" value="Thiosulf_sulfurTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000062978" description="Thiosulfate sulfurtransferase GlpE">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01009"/>
        </source>
    </evidence>
    <sequence length="108" mass="12112" checksum="49D4B461DEC49F05" modified="2005-12-06" version="1">MDQFECINVADAHQKLQEKEAVLVDIRDPQSFAMGHAVQTFHLTNDTLGAFMRDNDFDTPVMVMCYHGNSSKGAAQYLLQQGYDVVYSIDGGFEAWQRQFPAEVAYGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AQ1</accession>
    <name>NIKE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nickel import ATP-binding protein NikE</fullName>
            <ecNumber evidence="1">7.2.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nikE</name>
        <name type="ordered locus">SDY_3635</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000173685.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405095.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AQ1"/>
    <dbReference type="SMR" id="Q32AQ1"/>
    <dbReference type="STRING" id="300267.SDY_3635"/>
    <dbReference type="EnsemblBacteria" id="ABB63604">
        <property type="protein sequence ID" value="ABB63604"/>
        <property type="gene ID" value="SDY_3635"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3635"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4314"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_6"/>
    <dbReference type="OMA" id="LVERFCH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015413">
        <property type="term" value="F:ABC-type nickel transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014137">
        <property type="entry name" value="Nickel_NikE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02769">
        <property type="entry name" value="nickel_nikE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51248">
        <property type="entry name" value="NIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-0921">Nickel transport</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000274124" description="Nickel import ATP-binding protein NikE">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01712"/>
        </source>
    </evidence>
    <sequence length="268" mass="29713" checksum="BD3206E923399C0C" modified="2005-12-06" version="1">MTLLNVSDLSHHYAHGGFSGKHQHQAVLNNVSLTLKSGETVALLGRSGCGKSTLARLLIGLESPSQGNISWRGEPLAKLNRAQRKAFRRDIQMVFQDSISAVNPRKTVREILREPMRHLLSLKKSEQLARASEMLKAVDLDDSVLDKRPPQLSGGQLQRVCLARALAVEPKLLILDEAVSNLDLVLQAGVIRLLKKLQQQFGTACLFITHDLRLVERFCQRVMVMDNGQIVETQAVGDKLTFSSDAGRVLQNAVLPAFPVRRRTSEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AX0</accession>
    <name>Q32AX0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor of chromosomal ars operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arsR</name>
        <name evidence="2" type="ordered locus">SDY_3561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000008950.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405026.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AX0"/>
    <dbReference type="STRING" id="300267.SDY_3561"/>
    <dbReference type="EnsemblBacteria" id="ABB63535">
        <property type="protein sequence ID" value="ABB63535"/>
        <property type="gene ID" value="SDY_3561"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3561"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4226"/>
    <dbReference type="HOGENOM" id="CLU_097806_3_1_6"/>
    <dbReference type="OMA" id="DGREHCV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="117" mass="13267" checksum="81BC3F6F856D08A2" modified="2005-12-06" version="1">MSFLLPIQLFKILADETRLGIVLLLSELGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKKGKWVHYRLSPHIPAWAAKIIDEAWRCEQEKVQAIVRNLARQNCSADSKNICS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B39</accession>
    <name>RL29_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmC</name>
        <name type="ordered locus">SDY_3488</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000644743.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404957.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B39"/>
    <dbReference type="SMR" id="Q32B39"/>
    <dbReference type="STRING" id="300267.SDY_3488"/>
    <dbReference type="EnsemblBacteria" id="ABB63466">
        <property type="protein sequence ID" value="ABB63466"/>
        <property type="gene ID" value="SDY_3488"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3488"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4141"/>
    <dbReference type="HOGENOM" id="CLU_158491_1_2_6"/>
    <dbReference type="OMA" id="RFQMATS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000007607" description="50S ribosomal protein L29">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <sequence length="63" mass="7302" checksum="9A019F126B0AA061" modified="2005-12-06" version="1">MKAKELREKSVEELNTELLNLLREQFNLRMQVASGQLQQSHLLKQVRRDVARVKTLLNEKAGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B68</accession>
    <name>AROE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="1">SDH</shortName>
            <ecNumber evidence="1">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroE</name>
        <name type="ordered locus">SDY_3458</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000451221.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404928.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B68"/>
    <dbReference type="SMR" id="Q32B68"/>
    <dbReference type="STRING" id="300267.SDY_3458"/>
    <dbReference type="EnsemblBacteria" id="ABB63437">
        <property type="protein sequence ID" value="ABB63437"/>
        <property type="gene ID" value="SDY_3458"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3458"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4111"/>
    <dbReference type="HOGENOM" id="CLU_044063_2_1_6"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000021332" description="Shikimate dehydrogenase (NADP(+))">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="126"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <sequence length="272" mass="29495" checksum="CBB16F18A1BAF6AE" modified="2005-12-06" version="1">METYAVFGNPIAHSKSPFIHQQFAQQLNIEHPYGRVLAPINDFINTLNAFFRAGGKGANVTVPFKEEAFARADELTERAALAGAVNTLMRLEDGRLLGDNTDGVGLLSDLERLSFIRPGLRILLIGAGGASRGVLLPLLSLDCAVTITNRTVSRAEELAKLFEHTGSIQALGMDELEGHEFDLIINATSSGISGDIPAIPSSLIHPGIYCYDMFYQKGKTPFLAWCEQRGSKRNADGLGMLVAQAAHAFLLWHGVLPDVEPVIKLLQQELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B96</accession>
    <name>Q32B96_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quorum sensing regulator A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">qseA</name>
        <name evidence="3" type="ordered locus">SDY_3419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000440320.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404900.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B96"/>
    <dbReference type="STRING" id="300267.SDY_3419"/>
    <dbReference type="EnsemblBacteria" id="ABB63409">
        <property type="protein sequence ID" value="ABB63409"/>
        <property type="gene ID" value="SDY_3419"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3419"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4077"/>
    <dbReference type="HOGENOM" id="CLU_039613_16_2_6"/>
    <dbReference type="OMA" id="KHRYITH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="309" mass="34516" checksum="22DB31343EA1EF2F" modified="2005-12-06" version="1">MERLKRMSVFAKVVEFGSFTAAARQLQMSVSSISQTVSKLEDELQVKLLNRSTRSIGLTEAGRIYYQGCRRMLHEVQDVHEQLYAFNNTPIGTLRIGCSSTMAQNVLAGLTAKMLKEYPGLSVNLVTGIPAPDLIADGLDVVIRVGALQDSSLFSRRLGAMPMVVCAAKSYLTQYGIPEKPADLSSHSWLEYSVRPDNEFELIAPEGISTRLIPQGRFVTNDPMTLVRWLTAGAGLAYVPLMWVINEINRGELEILLPRYQSDPRPVYALYTEKDKLPLKVQVVINSLTDYFVEVGKLFQEMHGRGKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BG4</accession>
    <name>Q32BG4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">nusA</name>
        <name evidence="9" type="ordered locus">SDY_3348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001031056.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404832.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BG4"/>
    <dbReference type="STRING" id="300267.SDY_3348"/>
    <dbReference type="EnsemblBacteria" id="ABB63341">
        <property type="protein sequence ID" value="ABB63341"/>
        <property type="gene ID" value="SDY_3348"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3348"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4002"/>
    <dbReference type="HOGENOM" id="CLU_029242_0_0_6"/>
    <dbReference type="OMA" id="MDIDMSA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010214">
        <property type="entry name" value="Tscrpt_termin_fac_NusA_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01954">
        <property type="entry name" value="nusA_Cterm_rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="495" mass="54915" checksum="724DD5B617350AC7" modified="2005-12-06" version="1">MNKEILAVVEAVSNEKALPREKIFEALESALATATKKKYEQEIDVRVQIDRKSGDFDTFRRWLVVDEVTQPTKEITLEAARYEDESLNLGDYVEDQIESVTFDRITTQTAKQVIVQKVREAERAMVVDQFREHEGEIITGVVKKVNRDNISLDLGNNAEAVILREDMLPRENFRPGDRVRGVLYSVRPEARGAQLFVTRSKPEMLIELFRIEVPEIGEEVIEIKAAARDPGSRAKIAVKTNDKRIDPVGACVGMRGARVQAVSTELGGERIDIVLWDDNPAQFVINAMAPADVASIVVDEDKHTMDIAVEAGNLAQAIGRNGQNVRLASQLSGWELNVMTVDDLQAKHQAEAHAAIDTFTKYLDIDEDFATVLVEEGFSTLEELAYVPMKELLEIEGLDEPTVEALRERAKNALATIAQAQEESLGDNKPADDLLNLEGIDRDLTFKLAARGVCTLEDLAEQGIDDLADIEGLTDEKAGALIMAARNICWFGDEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BK1</accession>
    <name>TDCC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Threonine/serine transporter TdcC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">H(+)/threonine-serine symporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tdcC</name>
        <name type="ordered locus">SDY_3308</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) + L-threonine(in) = H(+)(out) + L-threonine(out)</text>
            <dbReference type="Rhea" id="RHEA:28883"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:28885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:28887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:28889"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000107728.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404795.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BK1"/>
    <dbReference type="SMR" id="Q32BK1"/>
    <dbReference type="STRING" id="300267.SDY_3308"/>
    <dbReference type="EnsemblBacteria" id="ABB63304">
        <property type="protein sequence ID" value="ABB63304"/>
        <property type="gene ID" value="SDY_3308"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3308"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3954"/>
    <dbReference type="HOGENOM" id="CLU_052043_1_1_6"/>
    <dbReference type="OMA" id="SPQNMAE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022889">
        <property type="term" value="F:serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015565">
        <property type="term" value="F:threonine efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01583">
        <property type="entry name" value="Thr_Ser_transp_TdcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018227">
        <property type="entry name" value="Amino_acid_transport_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004694">
        <property type="entry name" value="Hydroxy_aa_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023726">
        <property type="entry name" value="Thr/Ser_transpt_TdcC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35334:SF1">
        <property type="entry name" value="PTHR35334:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03222">
        <property type="entry name" value="Trp_Tyr_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00814">
        <property type="entry name" value="stp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0769">Symport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000309172" description="Threonine/serine transporter TdcC">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01583"/>
        </source>
    </evidence>
    <sequence length="443" mass="48879" checksum="C7566F71C94DF0AA" modified="2005-12-06" version="1">MSTSDSIVSSQTKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFVASLVLISLSLIPYWNSAVIDQVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYEKDFGRDFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANHFASMTGTKTTFAITLEYAASIIALVAIFKSFFGHYLGTLEGLNGLILKFGYKGDKTKVSLGKLNTLSMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRGRLDNVFVTVIGLLTILNIVYKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BL1</accession>
    <name>Q32BL1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator LYSR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhaJ</name>
        <name evidence="3" type="ordered locus">SDY_3297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001041017.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404785.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BL1"/>
    <dbReference type="STRING" id="300267.SDY_3297"/>
    <dbReference type="EnsemblBacteria" id="ABB63294">
        <property type="protein sequence ID" value="ABB63294"/>
        <property type="gene ID" value="SDY_3297"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3297"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3942"/>
    <dbReference type="HOGENOM" id="CLU_039613_35_1_6"/>
    <dbReference type="OMA" id="YVHKRSG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="301" mass="33627" checksum="2CC7A46196604FF2" modified="2005-12-06" version="1">MAKERALTLEALRVMDAIDRRGSFAAAADELGRVPSALSYTMQKLEEELDVVLFDRSGHRTKFTNVGRMLLERGRVLLEAADKLTTDAEALARGWETHLTIVTEALVPTPAFFPLIDKLAAKANTQLAIITEVLAGAWERLEQLEQGRADIVIAPDMHFRSSSEINSRKLYTLMNVYVAAPDHPIHQEPEPLSEVTRVKYRGIAVADTARERPVLTVQLLDKQPRLTVSTIEDKRQALLAGLGVATMPYPMVEKDIAEGRLRVVSPESTSEIDIIMAWRRDSMGEAKSWCLREIPKLFNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BZ9</accession>
    <name>Q32BZ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404647.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BZ9"/>
    <dbReference type="STRING" id="300267.SDY_3142"/>
    <dbReference type="EnsemblBacteria" id="ABB63156">
        <property type="protein sequence ID" value="ABB63156"/>
        <property type="gene ID" value="SDY_3142"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3142"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3751"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15380" checksum="434534FAE03D291D" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTLFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C06</accession>
    <name>Q32C06_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000758919.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404640.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C06"/>
    <dbReference type="STRING" id="300267.SDY_3135"/>
    <dbReference type="EnsemblBacteria" id="ABB63149">
        <property type="protein sequence ID" value="ABB63149"/>
        <property type="gene ID" value="SDY_3135"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3135"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3744"/>
    <dbReference type="HOGENOM" id="CLU_163394_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220749" evidence="1">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="9606" checksum="E9B58B4B8CAAEE80" modified="2005-12-06" version="1">MKKWKVRSALVALIVLLAGCSSNAQYNSSASGNVGTAWGGDVHSTVQGVSAERAWRDPAEMIVISYSTNVPSGYDRVYSIRINELGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C12</accession>
    <name>Q32C12_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Galactose-proton symport of transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galP</name>
        <name evidence="10" type="ordered locus">SDY_3129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001112301.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404634.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C12"/>
    <dbReference type="SMR" id="Q32C12"/>
    <dbReference type="STRING" id="300267.SDY_3129"/>
    <dbReference type="EnsemblBacteria" id="ABB63143">
        <property type="protein sequence ID" value="ABB63143"/>
        <property type="gene ID" value="SDY_3129"/>
    </dbReference>
    <dbReference type="GeneID" id="67415165"/>
    <dbReference type="KEGG" id="sdy:SDY_3129"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3739"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_6"/>
    <dbReference type="OMA" id="SCHEQEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="18"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="464" mass="50983" checksum="07E08935BD8E3F8E" modified="2005-12-06" version="1">MPDAKKQGRSNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIRESLQVKQSGWALFKENSNFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTMMHIGIHSPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNANTFWVYAALNVLFILLTLWLVPETKHVSLEHIERNLMKGRKLREIGAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C39</accession>
    <name>Q32C39_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Type II secretion system protein K</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gspK</name>
        <name evidence="12" type="ordered locus">SDY_3100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GSP K family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000633233.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404607.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C39"/>
    <dbReference type="STRING" id="300267.SDY_3100"/>
    <dbReference type="EnsemblBacteria" id="ABB63116">
        <property type="protein sequence ID" value="ABB63116"/>
        <property type="gene ID" value="SDY_3100"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3100"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3709"/>
    <dbReference type="HOGENOM" id="CLU_057294_0_0_6"/>
    <dbReference type="OMA" id="AYWYSIG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005628">
        <property type="entry name" value="GspK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038072">
        <property type="entry name" value="GspK_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38831">
        <property type="entry name" value="PTHR38831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03934">
        <property type="entry name" value="T2SSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002786">
        <property type="entry name" value="XcpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158544">
        <property type="entry name" value="SSF158544"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="325" mass="36561" checksum="D575AB91F1EA69DB" modified="2005-12-06" version="1">MITSPPKRGMALVVVLVLLAVMMLVTITLSGRMQQQLGRTRSQQEYQQALWYSASAESLALSALSLSLKNEKRVHLAQSWASGPRFFPLPQGQIAVTLRDAQACFNLNDLAQPTTASRPIAVQQLIALISRLNVPAYRAELIAESLWEFIDEDRSVQTRLGREDSEYLARSVPFYAANQPLADISEMRVVQGMDAGLYQKLKPLVCALPMTRQQININTLDVTQSVILEALFDPWLSPVQARALLQQRPAKGWEDVDQFLAQPLLADVDERTKKQLKTVLSVDSNYFWLRSDITVNEIELTMNSLIVRMGPQHFSVLWHQTGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C65</accession>
    <name>Q32C65_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404581.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C65"/>
    <dbReference type="STRING" id="300267.SDY_3073"/>
    <dbReference type="EnsemblBacteria" id="ABB63090">
        <property type="protein sequence ID" value="ABB63090"/>
        <property type="gene ID" value="SDY_3073"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3073"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3679"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_6"/>
    <dbReference type="OMA" id="YSMINRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="31"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="269" mass="30249" checksum="41CEBEB652594567" modified="2005-12-06" version="1">MVWLANPERYGQMQYCYCGKSGLRLPALSPGLWHNFGHINALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGRLLREDFAAYRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSYSPERTQKMVELLHEWKIPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLNGIPEDSRMHREGNKVRGLTPKMLTEANLNSLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C73</accession>
    <name>Q32C73_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cystathionine beta-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">metC</name>
        <name evidence="6" type="ordered locus">SDY_3065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L,L-cystathionine = L-homocysteine + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018220.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404573.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C73"/>
    <dbReference type="STRING" id="300267.SDY_3065"/>
    <dbReference type="EnsemblBacteria" id="ABB63082">
        <property type="protein sequence ID" value="ABB63082"/>
        <property type="gene ID" value="SDY_3065"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3065"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3671"/>
    <dbReference type="HOGENOM" id="CLU_018986_5_1_6"/>
    <dbReference type="OMA" id="GPYTYGR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004121">
        <property type="term" value="F:cystathionine beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006233">
        <property type="entry name" value="Cys_b_lyase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43500">
        <property type="entry name" value="PTHR43500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01324">
        <property type="entry name" value="cysta_beta_ly_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="395" mass="43276" checksum="3722B0D2864A07CE" modified="2005-12-06" version="1">MADKKLDTQLVNAGRSKKYTLGAVNSVIQRASSLVFESMEAKKHATRNRANGELFYGRRGTLTHFSLQQAMCELEGGAGCALFPCGAAAVANSILAFVEQGDHVLMTNTAYEPSQDFCSKILSKLGVTTLWFDPLIGADIVKHLQPNTKIVFLESPGSITMEVHDVPAIVAAVRSMVPDAIIMIDNTWAAGVLFKALDFGIDVSIQAATKYLVGHSDAMIGTAVCNARCWEQLRENAYLMGQMVDADTAYITSRGLRTLGVRLRQHHESSLKVAEWLAEHPQVARVNHPALPGSKGHEFWKRDFTGSSGLFSFVLKKKLNDEELANYLDNFSLFSMAYSWGGYESLILANQPEHIAAIRPQGEIDFSGTLIRLHIGLEDVDDLIADLDAGFARIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CG4</accession>
    <name>CYSI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfite reductase [NADPH] hemoprotein beta-component</fullName>
            <shortName evidence="1">SiR-HP</shortName>
            <shortName evidence="1">SiRHP</shortName>
            <ecNumber evidence="1">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysI</name>
        <name type="ordered locus">SDY_2965</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
        <text evidence="1">Binds 1 siroheme per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001290733.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404482.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CG4"/>
    <dbReference type="SMR" id="Q32CG4"/>
    <dbReference type="STRING" id="300267.SDY_2965"/>
    <dbReference type="EnsemblBacteria" id="ABB62991">
        <property type="protein sequence ID" value="ABB62991"/>
        <property type="gene ID" value="SDY_2965"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2965"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3557"/>
    <dbReference type="HOGENOM" id="CLU_001975_3_2_6"/>
    <dbReference type="OMA" id="MGMTHGD"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02041">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000068776" description="Sulfite reductase [NADPH] hemoprotein beta-component">
        <location>
            <begin position="1"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01540"/>
        </source>
    </evidence>
    <sequence length="570" mass="63954" checksum="4926A62E3B7F433B" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CQ7</accession>
    <name>Q32CQ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CQ7"/>
    <dbReference type="STRING" id="300267.SDY_2861"/>
    <dbReference type="EnsemblBacteria" id="ABB62898">
        <property type="protein sequence ID" value="ABB62898"/>
        <property type="gene ID" value="SDY_2861"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2861"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="OMA" id="PCNIGMI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="89" mass="10164" checksum="880AB007AEB40E5D" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKNIHPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CT8</accession>
    <name>Q32CT8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SpoU_sub_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yfiF</name>
        <name evidence="5" type="ordered locus">SDY_2824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000997403.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404358.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CT8"/>
    <dbReference type="SMR" id="Q32CT8"/>
    <dbReference type="STRING" id="300267.SDY_2824"/>
    <dbReference type="EnsemblBacteria" id="ABB62867">
        <property type="protein sequence ID" value="ABB62867"/>
        <property type="gene ID" value="SDY_2824"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2824"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3401"/>
    <dbReference type="HOGENOM" id="CLU_021322_2_1_6"/>
    <dbReference type="OMA" id="NRAEEMK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016479">
        <property type="entry name" value="YfiF_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429:SF2">
        <property type="entry name" value="PTHR46429:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006280">
        <property type="entry name" value="YfiF_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="4">
        <location>
            <begin position="109"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="345" mass="37784" checksum="9845E9884D8369BF" modified="2005-12-06" version="1">MNDEMKGKSGKVKVMYVRSDDDSDKRTHNPRTGKGGGRPGKSRADGGRRPARDDKQSQPRDRKWEDSPWRTVSRAPGDETPEKADHGGISGKSFIDPEVLRRQRAEETRVYGENACQALFQSRPEAIVRAWFIQSVTPRFKEALRWMAANRKAYHVVDEAELTKASGTEHHGGVCFLIKKRNGTTVQQWVSQAGAQDCVLALENESNPHNLGGMMRSCAHFGVKGVVVQDAALLESGAAIRTAEGGAEHVQPITGDNIVNVLDDFRQAGYTVVTTSSEQGKPLFKTSLPAKMVLVLGQEYEGLPDAARDPNDLRVKIDGTGNVAGLNISVATGVLLGEWWRQNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CU5</accession>
    <name>Q32CU5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase SrmB</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 12" type="primary">srmB</name>
        <name evidence="12" type="ordered locus">SDY_2817</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. SrmB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000219209.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404351.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CU5"/>
    <dbReference type="STRING" id="300267.SDY_2817"/>
    <dbReference type="EnsemblBacteria" id="ABB62860">
        <property type="protein sequence ID" value="ABB62860"/>
        <property type="gene ID" value="SDY_2817"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2817"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3393"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_6"/>
    <dbReference type="OMA" id="YDIELYQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00967">
        <property type="entry name" value="DEAD_helicase_SrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028621">
        <property type="entry name" value="DEAD_helicase_SrmB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="11">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="35"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="238"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="382"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="444" mass="49999" checksum="E74C33CEC132D7D7" modified="2005-12-06" version="1">MTVTTFSELELYESLLEALQDKGFTRPTAIQAAAIPPALDGRDVLGSAPTGTGKTAAYLLPALQHLLDFPRKKSGPPRILILTPTRELAMQVADHARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATTGRLLQYIKEENFDCRAVETLILDEADRMLDMGFAQDIEHIAGETRWRKQTLLFSATLEGDAIQDFAERLLEDPVEVSANPSTRERKKIHQWYYRADDLEHKTALLVHLLKQPEATRSIVFVRKRERVHELANWLREAGINNRYLEGEMVQGKRNEAIKRLTEGRVNVLVATDVAARGIDIPDVSHVFNFDMPRSGDTYLHRIGRTARAGRKGTAISLVEAHDHLLLGKVGRYIEEPIKARVIDELRPKTRAPSEKQTGKPSKKVLAKRAEKKKAKEKEKPRVKKRHRDTKNIGKRRKPSGTGVPPQTTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CZ4</accession>
    <name>Q32CZ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative yhbH sigma 54 modulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yfiA</name>
        <name evidence="3" type="ordered locus">SDY_2768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000178456.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404302.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CZ4"/>
    <dbReference type="SMR" id="Q32CZ4"/>
    <dbReference type="STRING" id="300267.SDY_2768"/>
    <dbReference type="EnsemblBacteria" id="ABB62811">
        <property type="protein sequence ID" value="ABB62811"/>
        <property type="gene ID" value="SDY_2768"/>
    </dbReference>
    <dbReference type="GeneID" id="67414085"/>
    <dbReference type="KEGG" id="sdy:SDY_2768"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3335"/>
    <dbReference type="HOGENOM" id="CLU_071472_3_0_6"/>
    <dbReference type="OMA" id="DMYVAIN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="113" mass="12785" checksum="562901F819836A87" modified="2005-12-06" version="1">MTMNITSKQMEITPAIRQHVADRLAKLEKWQTHLINPHIILSKEPQGFVADATINTPNGVLVASGKHEDMYTAINELINKLERQLNKLQHKGEARRAATSVKDANFVEEVEEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D45</accession>
    <name>RLMN_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="1">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmN</name>
        <name type="ordered locus">SDY_2713</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000003317.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404251.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D45"/>
    <dbReference type="SMR" id="Q32D45"/>
    <dbReference type="STRING" id="300267.SDY_2713"/>
    <dbReference type="EnsemblBacteria" id="ABB62760">
        <property type="protein sequence ID" value="ABB62760"/>
        <property type="gene ID" value="SDY_2713"/>
    </dbReference>
    <dbReference type="GeneID" id="66673595"/>
    <dbReference type="KEGG" id="sdy:SDY_2713"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3271"/>
    <dbReference type="HOGENOM" id="CLU_029101_0_0_6"/>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000350411" description="Dual-specificity RNA methyltransferase RlmN">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="111"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="1">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="(transient)" evidence="1">
        <location>
            <begin position="118"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="384" mass="43086" checksum="92C1BDCC840FCE7B" modified="2005-12-06" version="1">MSEQLVTPENVTTKDGKINLLDLNRQQMREFFKDLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLNNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDEIRDEIVPINKKYNIETFLAAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKDTPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEAIDIKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D61</accession>
    <name>Q32D61_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D61"/>
    <dbReference type="EnsemblBacteria" id="ABB62744">
        <property type="protein sequence ID" value="ABB62744"/>
        <property type="gene ID" value="SDY_2697"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2697"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="9576" checksum="9B6F96351AEE964B" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGTTHYSLLYTLRKIRHLRSSKEESKCIAYKGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D75</accession>
    <name>Q32D75_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">perM</name>
        <name evidence="7" type="ordered locus">SDY_2682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000892044.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404221.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D75"/>
    <dbReference type="STRING" id="300267.SDY_2682"/>
    <dbReference type="EnsemblBacteria" id="ABB62730">
        <property type="protein sequence ID" value="ABB62730"/>
        <property type="gene ID" value="SDY_2682"/>
    </dbReference>
    <dbReference type="GeneID" id="66673642"/>
    <dbReference type="KEGG" id="sdy:SDY_2682"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3236"/>
    <dbReference type="HOGENOM" id="CLU_031275_8_0_6"/>
    <dbReference type="OMA" id="WRTLTAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="353" mass="39194" checksum="E1CB8EB1E242FC3B" modified="2005-12-06" version="1">MLEMLMQWYRRRFSDPEAIALLVILVAGFGIIFFFSGLLAPLLVAIVLAYLLEWPTVRLQSIGCSRRWATSIVLVVFVGILLLMAFVVLPIAWQQGIYLIRDMPGMLNKLSDFAATLPRRYPALMDAGIIDAMAENMRSRMLTMGDSVVKISLASLVGLLTIAVYLVLVPLMVFFLLKDKEQMLNAVRRVLPRNRGLAGQVWKEMNQQITNYIRGKVLEMIVVGIATWLGFLLFGLNYSLLLAVLVGFSVLIPYIGAFVVTIPVVGVALFQFGAGTEFWSCFAVYLIIQALDGNLLVPVLFSEAVNLHPLVIILSVVIFGGLWGFWGVFFAIPLATLIKAVIHAWPDGQIAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DM9</accession>
    <name>Q32DM9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histidine transport, membrane protein M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisM</name>
        <name evidence="9" type="ordered locus">SDY_2506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000569958.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404067.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DM9"/>
    <dbReference type="SMR" id="Q32DM9"/>
    <dbReference type="STRING" id="300267.SDY_2506"/>
    <dbReference type="EnsemblBacteria" id="ABB62576">
        <property type="protein sequence ID" value="ABB62576"/>
        <property type="gene ID" value="SDY_2506"/>
    </dbReference>
    <dbReference type="GeneID" id="66673810"/>
    <dbReference type="KEGG" id="sdy:SDY_2506"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3021"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_4_6"/>
    <dbReference type="OMA" id="FFQNAWY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="23"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="238" mass="26870" checksum="0307840A94836348" modified="2005-12-06" version="1">MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVKGTEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKPSSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DP1</accession>
    <name>Q32DP1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yfcC</name>
        <name evidence="7" type="ordered locus">SDY_2494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DP1"/>
    <dbReference type="STRING" id="300267.SDY_2494"/>
    <dbReference type="EnsemblBacteria" id="ABB62564">
        <property type="protein sequence ID" value="ABB62564"/>
        <property type="gene ID" value="SDY_2494"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2494"/>
    <dbReference type="HOGENOM" id="CLU_035307_0_0_6"/>
    <dbReference type="OMA" id="GTRELKW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018387">
        <property type="entry name" value="YcgA/YfcC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43652:SF6">
        <property type="entry name" value="PTHR43652:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="513" mass="55559" checksum="392B170BB8C95974" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DW8</accession>
    <name>Q32DW8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein Roi of bacteriophage BP-933W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403978.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DW8"/>
    <dbReference type="EnsemblBacteria" id="ABB62487">
        <property type="protein sequence ID" value="ABB62487"/>
        <property type="gene ID" value="SDY_2414"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2414"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2912"/>
    <dbReference type="HOGENOM" id="CLU_046670_7_3_6"/>
    <dbReference type="OMA" id="NAPLIHF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005039">
        <property type="entry name" value="Ant_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014054">
        <property type="entry name" value="Phage_regulatory_Rha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03374">
        <property type="entry name" value="ANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09669">
        <property type="entry name" value="Phage_pRha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANT" evidence="1">
        <location>
            <begin position="128"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="242" mass="27233" checksum="FBADC982DD9B1FAA" modified="2005-12-06" version="1">MTMNELINSNAIKMTSIEIAELVGKRHDNVKRTIETLAKNGVIRHPQFEVSERINNLGFNVQYEHYVFEGEQGKRDSIIVVAQLSPEFTARLVDRWRELEGATAKIPQTFSEALRLAADLEDQKAELEKQLALAAPKVEFADRVSEASGILIGNFAKVVGIGPNKLFAWMRDHKILIASGSRRNVPMQEYMDRGYFTVKETAVNTNHGIQISFTTKITGRGQQWLTRKLLYNGMLKVTGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E11</accession>
    <name>Q32E11_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Replication-associated recombination protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ycaJ</name>
        <name evidence="5" type="ordered locus">SDY_2369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000067755.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403935.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E11"/>
    <dbReference type="SMR" id="Q32E11"/>
    <dbReference type="STRING" id="300267.SDY_2369"/>
    <dbReference type="EnsemblBacteria" id="ABB62444">
        <property type="protein sequence ID" value="ABB62444"/>
        <property type="gene ID" value="SDY_2369"/>
    </dbReference>
    <dbReference type="GeneID" id="66670834"/>
    <dbReference type="KEGG" id="sdy:SDY_2369"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2862"/>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_6"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="49"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="447" mass="49626" checksum="116ACBE38E4E4A3A" modified="2005-12-06" version="1">MSNLSLDFSDNTFQPLAARMRPENLAQYIGQQHLLAAGKPLPRAIEAGHLHSMILWGPPGTGKTTLAEVIARYANADVERISAVTSGVKEIREAIERARQNRNAGRRTILFVDEVHRFNKSQQDAFLPHIEDGTITFIGATTENPSFELNSALLSRARVYLLKSLSTEDIEQVLTQAMEDKTRGYGGQDIVLPDETRRAIAELVNGDARRALNTLEMMADMAEVDDSGKRVLKPELLTEIAGERSARFDNKGDRFYDLISALHKSVRGSAPDAALYWYARIITAGGDPLYVARRCLAIASEDVGNADPRAMQVAIAAWDCFTRVGPAEGERAIAQAIVYLACAPKSNAVYTAFKAALADARERPDYDVPVHLRNAPTKLMKEMGYGQEYRYAHDEANAYAAGEVYFPPEIAQTRYYFPTNRGLEGKIGEKLAWLAEQDQNSPIKRYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E34</accession>
    <name>MSBA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent lipid A-core flippase</fullName>
            <ecNumber evidence="1">7.5.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msbA</name>
        <name type="ordered locus">SDY_2344</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + lipid A-core oligosaccharideSide 1 = ADP + phosphate + lipid A-core oligosaccharideSide 2.</text>
            <dbReference type="EC" id="7.5.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000551270.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403912.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E34"/>
    <dbReference type="SMR" id="Q32E34"/>
    <dbReference type="STRING" id="300267.SDY_2344"/>
    <dbReference type="EnsemblBacteria" id="ABB62421">
        <property type="protein sequence ID" value="ABB62421"/>
        <property type="gene ID" value="SDY_2344"/>
    </dbReference>
    <dbReference type="GeneID" id="66670810"/>
    <dbReference type="KEGG" id="sdy:SDY_2344"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2828"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_6"/>
    <dbReference type="OMA" id="WGTYLVK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011917">
        <property type="entry name" value="ABC_transpr_lipidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02203">
        <property type="entry name" value="MsbA_lipidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51239">
        <property type="entry name" value="MSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000271657" description="ATP-dependent lipid A-core flippase">
        <location>
            <begin position="1"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="342"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01703"/>
        </source>
    </evidence>
    <sequence length="582" mass="64461" checksum="3D52A3482174A7FE" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-12" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E37</accession>
    <name>YCAR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein YcaR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycaR</name>
        <name type="ordered locus">SDY_2341</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000350058.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403909.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E37"/>
    <dbReference type="SMR" id="Q32E37"/>
    <dbReference type="STRING" id="300267.SDY_2341"/>
    <dbReference type="EnsemblBacteria" id="ABB62418">
        <property type="protein sequence ID" value="ABB62418"/>
        <property type="gene ID" value="SDY_2341"/>
    </dbReference>
    <dbReference type="GeneID" id="66670807"/>
    <dbReference type="KEGG" id="sdy:SDY_2341"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2825"/>
    <dbReference type="HOGENOM" id="CLU_155659_3_1_6"/>
    <dbReference type="OMA" id="ELICHAD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000291172" description="UPF0434 protein YcaR">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <sequence length="60" mass="6855" checksum="EA3DC2FDA412B535" modified="2005-12-06" version="1">MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E63</accession>
    <name>Q32E63_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">PTS system, fructose-specific transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">fruA</name>
        <name evidence="17" type="ordered locus">SDY_2315</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000854441.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403883.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E63"/>
    <dbReference type="STRING" id="300267.SDY_2315"/>
    <dbReference type="EnsemblBacteria" id="ABB62392">
        <property type="protein sequence ID" value="ABB62392"/>
        <property type="gene ID" value="SDY_2315"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2315"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2793"/>
    <dbReference type="HOGENOM" id="CLU_013155_0_0_6"/>
    <dbReference type="OMA" id="CKLMAPH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="15">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="16">
        <location>
            <begin position="226"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB62392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="563" mass="57503" checksum="4CABB9BE5A8FCCC6" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E69</accession>
    <name>Q32E69_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E69"/>
    <dbReference type="STRING" id="300267.SDY_2309"/>
    <dbReference type="EnsemblBacteria" id="ABB62386">
        <property type="protein sequence ID" value="ABB62386"/>
        <property type="gene ID" value="SDY_2309"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2309"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="97" mass="10748" checksum="D930F35C835B951D" modified="2005-12-06" version="1">MSRKTQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGTLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILCTGVAEKYALIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EE1</accession>
    <name>Q32EE1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0033 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yeeD</name>
        <name evidence="3" type="ordered locus">SDY_2230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000985271.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403805.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EE1"/>
    <dbReference type="STRING" id="300267.SDY_2230"/>
    <dbReference type="EnsemblBacteria" id="ABB62314">
        <property type="protein sequence ID" value="ABB62314"/>
        <property type="gene ID" value="SDY_2230"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2230"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2695"/>
    <dbReference type="HOGENOM" id="CLU_165255_0_3_6"/>
    <dbReference type="OMA" id="SWTITVQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8090" checksum="AFD60F654F5771E9" modified="2005-12-06" version="1">MAIKKLDVVTQVCPFPLIEAKAALAEMASGDELVIEFDCTQATEAIPQWAAEEGHAITDYQQIGDAAWSIAVQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EI2</accession>
    <name>Q32EI2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">baeS</name>
        <name evidence="12" type="ordered locus">SDY_2187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000675153.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403764.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EI2"/>
    <dbReference type="STRING" id="300267.SDY_2187"/>
    <dbReference type="EnsemblBacteria" id="ABB62273">
        <property type="protein sequence ID" value="ABB62273"/>
        <property type="gene ID" value="SDY_2187"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2187"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2645"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_6"/>
    <dbReference type="OMA" id="RTSWLIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="187"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="247"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="467" mass="52106" checksum="3FE05786AC64D941" modified="2005-12-06" version="1">MKFWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQYAQHGNWRFLRNNDRFVFQILRSFEHDNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFDKQQRQTSWLIVALATLLAALATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELSKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETMASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKAPVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLKISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EM9</accession>
    <name>Q32EM9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-galactoside transport and galactose taxis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mglC</name>
        <name evidence="8" type="ordered locus">SDY_2137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403717.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EM9"/>
    <dbReference type="STRING" id="300267.SDY_2137"/>
    <dbReference type="EnsemblBacteria" id="ABB62226">
        <property type="protein sequence ID" value="ABB62226"/>
        <property type="gene ID" value="SDY_2137"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2137"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2579"/>
    <dbReference type="HOGENOM" id="CLU_028880_1_0_6"/>
    <dbReference type="OMA" id="ACILQVL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030158">
        <property type="entry name" value="MglC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32196:SF18">
        <property type="entry name" value="PTHR32196:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="297" mass="31213" checksum="1BD996FD40025E04" modified="2005-12-06" version="1">MNLSNILTQSSVRIIIALGVAGLIVTQGTDLSAGRQVGLAAVVAATLLQSMDNANKVFPEMATMPIALVILIVCAIGAVIGLINGLIIAYLNVTPFITTLGTMIIVYGINSLYYDFVGASPISGFDSGFSTFAQGFVALGSFRLSYITFYALIAVAFVWVLWNKTRFGKNIFAIGGNPEAAKVSGVNVGLNLLMIYALSGVFYAFGGMLEAGRIGSATNNLGFMYELDAIAACVVGGVSFSGGVGTVIGVVTGVIIFTVINYGLTYIGVNPYWQYIIKGAIIIFAVALDSLKYARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EN4</accession>
    <name>Q32EN4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EN4"/>
    <dbReference type="EnsemblBacteria" id="ABB62221">
        <property type="protein sequence ID" value="ABB62221"/>
        <property type="gene ID" value="SDY_2131"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2131"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="9661" checksum="91F5BC169F665230" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITKWCRSLFDKYQTGILIMLIFLRRFPPLMHG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EQ7</accession>
    <name>END4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable endonuclease 4</fullName>
            <ecNumber evidence="1">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfo</name>
        <name type="ordered locus">SDY_2107</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000873894.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403689.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EQ7"/>
    <dbReference type="SMR" id="Q32EQ7"/>
    <dbReference type="STRING" id="300267.SDY_2107"/>
    <dbReference type="EnsemblBacteria" id="ABB62198">
        <property type="protein sequence ID" value="ABB62198"/>
        <property type="gene ID" value="SDY_2107"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2107"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2537"/>
    <dbReference type="HOGENOM" id="CLU_025885_0_4_6"/>
    <dbReference type="OMA" id="HPGSHLK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000011333" description="Probable endonuclease 4">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <sequence length="285" mass="31480" checksum="EAAE5861E54C47FD" modified="2005-12-06" version="1">MKYIGAHVSAAGGLANAAIRAAEIDATAFALFTKNQRQWRAAPLTTQTIDEFKAACEKYHYTSAQILPHDSYLINLGHPVTEALEKSRDAFIDEMQRCEQLGLSLLNFHPGSHLMQISEEDCLARIAESINIALDKTQGVTAVIENTAGQGSNLGFKFEHLAAIIDGVEDKSRVGVCIDTCHAFAAGYDLRTPAECEKTFADFARTVGFKYLRGMHLNDAKSTFGSRVDRHHSLGEGNIGHDAFRWIMQDDRFDGIPLILETINPDIWAEEIAWLKAQQTEKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EV6</accession>
    <name>Q32EV6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-amino-4-deoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pabC</name>
        <name evidence="6" type="ordered locus">SDY_2054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000478706.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403640.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EV6"/>
    <dbReference type="STRING" id="300267.SDY_2054"/>
    <dbReference type="EnsemblBacteria" id="ABB62149">
        <property type="protein sequence ID" value="ABB62149"/>
        <property type="gene ID" value="SDY_2054"/>
    </dbReference>
    <dbReference type="GeneID" id="66670638"/>
    <dbReference type="KEGG" id="sdy:SDY_2054"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2469"/>
    <dbReference type="HOGENOM" id="CLU_020844_2_1_6"/>
    <dbReference type="OMA" id="VPWTRNE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01559">
        <property type="entry name" value="ADCL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017824">
        <property type="entry name" value="Aminodeoxychorismate_lyase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03461">
        <property type="entry name" value="pabC_Proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="269" mass="29796" checksum="AED08A26BEA8662F" modified="2005-12-06" version="1">MFLINGYKQESLAVSDRATQFGDGCFTTARVIDGKVSLLSAHIQRLQDACQRLMISCDFWPQLEQEMKTLAAEQQNGVLKVVISRGSGGRGYSTLNSGPATRILSVTAYPAHYDRLRNEGMTLALSPVRLGRNPHLAGIKHLNRLEQVLIRSHLEQTNADEALVLDSEGWVTECCAANLFWRKGNVVYTPRLDQAGVNGIMRQFCIRLLAQSSYQLVEVQASLEEALQADEMVICNALMPVMPVRACGDVSFSSATLYEYLAPLCERPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F91</accession>
    <name>Q32F91_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major outer membrane lipoprotein Lpp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">lpp</name>
        <name evidence="8" type="ordered locus">SDY_1908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell outer membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Periplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Cell wall</location>
            <topology evidence="3">Peptidoglycan-anchor</topology>
        </subcellularLocation>
        <text evidence="3">Attached via its lipidated N-terminus to the inner leaflet of the outer membrane. Attached to the peptidoglycan network (PGN) via its C-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Lpp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000648420.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403505.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F91"/>
    <dbReference type="SMR" id="Q32F91"/>
    <dbReference type="STRING" id="300267.SDY_1908"/>
    <dbReference type="EnsemblBacteria" id="ABB62014">
        <property type="protein sequence ID" value="ABB62014"/>
        <property type="gene ID" value="SDY_1908"/>
    </dbReference>
    <dbReference type="GeneID" id="67415618"/>
    <dbReference type="KEGG" id="sdy:SDY_1908"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2297"/>
    <dbReference type="HOGENOM" id="CLU_166934_2_1_6"/>
    <dbReference type="OMA" id="ANDRIDN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043580">
        <property type="term" value="P:periplasmic space organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00843">
        <property type="entry name" value="Lpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006817">
        <property type="entry name" value="Lipoprotein_leucine-zipper_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016367">
        <property type="entry name" value="MOM_Lpp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38763">
        <property type="entry name" value="PTHR38763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04728">
        <property type="entry name" value="LPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002855">
        <property type="entry name" value="Murein-lipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="3 4" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220953" description="Major outer membrane lipoprotein Lpp" evidence="6">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="LPP" evidence="7">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" evidence="3">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-murein peptidoglycan lysine" evidence="3 4">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="3 5">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="3 5">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002855-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002855-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="78" mass="8323" checksum="19F41D5251913C93" modified="2005-12-06" version="1">MKATKLVLGAVILGSTLLAGCSSNAKIDQLSSDVQTLNAKVDQLSNDVNAMRSDVQAAKDDAARANQRLDNMATKYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F95</accession>
    <name>Q32F95_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fumarase D</fullName>
            <ecNumber evidence="4">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FumD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000528342.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403501.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F95"/>
    <dbReference type="SMR" id="Q32F95"/>
    <dbReference type="STRING" id="300267.SDY_1904"/>
    <dbReference type="EnsemblBacteria" id="ABB62010">
        <property type="protein sequence ID" value="ABB62010"/>
        <property type="gene ID" value="SDY_1904"/>
    </dbReference>
    <dbReference type="GeneID" id="66674432"/>
    <dbReference type="KEGG" id="sdy:SDY_1904"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2292"/>
    <dbReference type="HOGENOM" id="CLU_2755438_0_0_6"/>
    <dbReference type="OMA" id="ALYQEMC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024493">
        <property type="entry name" value="FumD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10965">
        <property type="entry name" value="DUF2767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="7907" checksum="A98BDA2AADEF5C32" modified="2005-12-06" version="1">MGNRTKEDELYREMCRVVGKVVLEMRDLGQEPKHIVIAGVLRTALANKRIQRSELEKQAMETVINALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FF6</accession>
    <name>Q32FF6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS4 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FF6"/>
    <dbReference type="STRING" id="300267.SDY_1840"/>
    <dbReference type="EnsemblBacteria" id="ABB61949">
        <property type="protein sequence ID" value="ABB61949"/>
        <property type="gene ID" value="SDY_1840"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1840"/>
    <dbReference type="HOGENOM" id="CLU_028400_3_0_6"/>
    <dbReference type="OMA" id="MELKWHT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024473">
        <property type="entry name" value="Transposases_IS4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13006">
        <property type="entry name" value="Nterm_IS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nterm_IS4" evidence="1">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="195" mass="22185" checksum="602394FC74354B25" modified="2005-12-06" version="1">MFPDFFMHIGQALDLVSRYDSLRNPLTSLGDYLDPELISRCLAESGTVTLRKRRLPLEMMVWCIVGMALERKEPLHQIVNRLDIMLPGNRPFVAPSAVIQARQRLGSEAVRRVFTKTAQLWHNATPHPHWCGLTLLAIDGVFWRTPDTPENDAAFPRQTHAGNPALYPQVKMVCQMDDQPSADGCSLRHDEEQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FH5</accession>
    <name>Q32FH5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000222172.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403421.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FH5"/>
    <dbReference type="STRING" id="300267.SDY_1819"/>
    <dbReference type="EnsemblBacteria" id="ABB61930">
        <property type="protein sequence ID" value="ABB61930"/>
        <property type="gene ID" value="SDY_1819"/>
    </dbReference>
    <dbReference type="GeneID" id="66674380"/>
    <dbReference type="KEGG" id="sdy:SDY_1819"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2192"/>
    <dbReference type="HOGENOM" id="CLU_129278_0_0_6"/>
    <dbReference type="OMA" id="MVRFNTP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025229">
        <property type="entry name" value="YniB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14002">
        <property type="entry name" value="YniB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="178" mass="20367" checksum="33D79A84D3626C3F" modified="2005-12-06" version="1">MTYQQAGRIAVLKRILGWVIFIPALISTLISLLKFMNTRQENQEGINAVMLDFTHVMIDMMQANTPFLNLFWYNSPTPNFNGGVNVMFWVIFILIFVGLALQDSGARMSRQARFLREGVEDQLILEKAKGEEGLTREQIESRIVVPHHTIFLQFFSLYILPVICIAAGYVFFSLLGFI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FI5</accession>
    <name>SYFA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheS</name>
        <name type="ordered locus">SDY_1809</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000018581.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403411.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FI5"/>
    <dbReference type="SMR" id="Q32FI5"/>
    <dbReference type="STRING" id="300267.SDY_1809"/>
    <dbReference type="EnsemblBacteria" id="ABB61920">
        <property type="protein sequence ID" value="ABB61920"/>
        <property type="gene ID" value="SDY_1809"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1809"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2181"/>
    <dbReference type="HOGENOM" id="CLU_025086_0_1_6"/>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000232024" description="Phenylalanine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with beta subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <sequence length="327" mass="36788" checksum="6A67484CF905EB75" modified="2005-12-06" version="1">MSHLAELVASAKAAISQASDVAALDNVRVEYLGKKGHLTLQMTTLRELPPEERPAAGAVINEAKEQVQQALNARKAELESAALNARLAADTIDVSLPGRRIENGGLHPVTRTIDRIESFFGELGFTVATGPEIEDDYHNFDALNIPGHHPARADHDTFWFDATRLLRTQTSGVQIRTMKAQQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFFEEDLQIRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEVYSGFAFGMGMERLTMLRYGVTDLRSFFENDLRFLKQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FT7</accession>
    <name>Q32FT7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1971 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yeaR</name>
        <name evidence="2" type="ordered locus">SDY_1697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000939317.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403309.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FT7"/>
    <dbReference type="SMR" id="Q32FT7"/>
    <dbReference type="STRING" id="300267.SDY_1697"/>
    <dbReference type="EnsemblBacteria" id="ABB61818">
        <property type="protein sequence ID" value="ABB61818"/>
        <property type="gene ID" value="SDY_1697"/>
    </dbReference>
    <dbReference type="GeneID" id="58462294"/>
    <dbReference type="KEGG" id="sdy:SDY_1697"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2046"/>
    <dbReference type="HOGENOM" id="CLU_147375_1_0_6"/>
    <dbReference type="OMA" id="ASIWKRH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015392">
        <property type="entry name" value="DUF1971"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014510">
        <property type="entry name" value="Tellurite-R_YeaR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09313">
        <property type="entry name" value="DUF1971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020632">
        <property type="entry name" value="YeaR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1971" evidence="1">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13611" checksum="F604B7C907AF686F" modified="2005-12-06" version="1">MLQIPQNYIHTRSTPFWNKQTAPAGIFERHLDKGTRPGVYPRLSVMHGAVKYLGYADEHSAEPDQVILIEAGQFAVFPPEKWHNIEAMTDDTYFNIDFFVAPEVLMEGAQQRKVIHNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G25</accession>
    <name>Q32G25_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G25"/>
    <dbReference type="STRING" id="300267.SDY_1602"/>
    <dbReference type="EnsemblBacteria" id="ABB61730">
        <property type="protein sequence ID" value="ABB61730"/>
        <property type="gene ID" value="SDY_1602"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1602"/>
    <dbReference type="HOGENOM" id="CLU_2525709_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00267">
        <property type="entry name" value="Porin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="9505" checksum="51683A41A0577A36" modified="2005-12-06" version="1">MVINSTFMARLPLYVILLMISVTMVIKLMPVSALKINDQMIGFGHWEYDFKGYNDEANGSRGNKTRLAYAGLVMLPISRTCVFQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G66</accession>
    <name>MDTJ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spermidine export protein MdtJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mdtJ</name>
        <name type="ordered locus">SDY_1553</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the excretion of spermidine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with MdtI.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000276149.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403180.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G66"/>
    <dbReference type="SMR" id="Q32G66"/>
    <dbReference type="STRING" id="300267.SDY_1553"/>
    <dbReference type="EnsemblBacteria" id="ABB61689">
        <property type="protein sequence ID" value="ABB61689"/>
        <property type="gene ID" value="SDY_1553"/>
    </dbReference>
    <dbReference type="GeneID" id="66674509"/>
    <dbReference type="KEGG" id="sdy:SDY_1553"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1862"/>
    <dbReference type="HOGENOM" id="CLU_133067_0_0_6"/>
    <dbReference type="OMA" id="MRSWIYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042221">
        <property type="term" value="P:response to chemical"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01598">
        <property type="entry name" value="MdtJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023740">
        <property type="entry name" value="Spermidine_export_MdtJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561:SF2">
        <property type="entry name" value="PTHR30561:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000331181" description="Spermidine export protein MdtJ">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01598"/>
        </source>
    </evidence>
    <sequence length="121" mass="13115" checksum="B24330AF5BB181B5" modified="2005-12-06" version="1">MYIYWILLGLAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLFDESLSLMKIAGLTTLVAGIVLIKSGTRKARKPELEVNHGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G78</accession>
    <name>Q32G78_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activator of ntrL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">osmE</name>
        <name evidence="4" type="ordered locus">SDY_1541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001039044.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403168.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G78"/>
    <dbReference type="SMR" id="Q32G78"/>
    <dbReference type="STRING" id="300267.SDY_1541"/>
    <dbReference type="EnsemblBacteria" id="ABB61677">
        <property type="protein sequence ID" value="ABB61677"/>
        <property type="gene ID" value="SDY_1541"/>
    </dbReference>
    <dbReference type="GeneID" id="66674366"/>
    <dbReference type="KEGG" id="sdy:SDY_1541"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1846"/>
    <dbReference type="HOGENOM" id="CLU_161369_1_0_6"/>
    <dbReference type="OMA" id="VTMIHAR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037873">
        <property type="entry name" value="BamE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007450">
        <property type="entry name" value="Lipoprotein_SmpA/OmlA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04355">
        <property type="entry name" value="SmpA_OmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220831" evidence="2">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="SmpA_OmlA" evidence="3">
        <location>
            <begin position="33"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="12021" checksum="CEF42E0DD8077550" modified="2005-12-06" version="1">MNKNMAGILSAAAVLTMLAGCTAYDRTKDQFVQPVVKDVKKGMSRAQVAQIAGKPSSEVSMIHARGTCQTYILGQRDGKAETYFVALDDTGHVINSGYQTCAEYDTDPQAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GD1</accession>
    <name>Q32GD1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yeaF</name>
        <name evidence="6" type="ordered locus">SDY_1485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MipA/OmpV family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000163771.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403115.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GD1"/>
    <dbReference type="STRING" id="300267.SDY_1485"/>
    <dbReference type="EnsemblBacteria" id="ABB61624">
        <property type="protein sequence ID" value="ABB61624"/>
        <property type="gene ID" value="SDY_1485"/>
    </dbReference>
    <dbReference type="GeneID" id="58391373"/>
    <dbReference type="KEGG" id="sdy:SDY_1485"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1773"/>
    <dbReference type="HOGENOM" id="CLU_063465_3_0_6"/>
    <dbReference type="OMA" id="EVKDSPM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010583">
        <property type="entry name" value="MipA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38776">
        <property type="entry name" value="PTHR38776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06629">
        <property type="entry name" value="MipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221103" evidence="5">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="248" mass="27831" checksum="6571B0D7A47A0525" modified="2005-12-06" version="1">MTKLKLLALGVLIATSAGVAHAEGKFSLGAGVGVVEHPYKDYDTDVYPVPVINYEGDNFWFRGLGGGYYLWNDATDKLSITAYWSPLYFKAKDSGDHQMRHLDDRKSTMMAGLSYAHFTQYGYLRTTLAGDTLDNSNGIVWDMAWLYRYTNGGLTVTPGIGVQWNSENQNEYYYGVSRKESARSGLRGYNPNDSWSPYLELSASYNFLGDWSVYGTARYTRLSDEVTDSPMVDKSWTGLISTGITYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GL9</accession>
    <name>Q32GL9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yjhS</name>
        <name evidence="4" type="ordered locus">SDY_1391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000874472.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403027.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GL9"/>
    <dbReference type="EnsemblBacteria" id="ABB61536">
        <property type="protein sequence ID" value="ABB61536"/>
        <property type="gene ID" value="SDY_1391"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1391"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1652"/>
    <dbReference type="HOGENOM" id="CLU_014323_1_1_6"/>
    <dbReference type="OMA" id="SINIAYH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013619">
        <property type="entry name" value="DUF1737"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08410">
        <property type="entry name" value="DUF1737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1737" evidence="3">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="2">
        <location>
            <begin position="147"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="636" mass="68952" checksum="00C9102BF73E1039" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GN7</accession>
    <name>Q32GN7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GN7"/>
    <dbReference type="STRING" id="300267.SDY_1373"/>
    <dbReference type="EnsemblBacteria" id="ABB61518">
        <property type="protein sequence ID" value="ABB61518"/>
        <property type="gene ID" value="SDY_1373"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1373"/>
    <dbReference type="HOGENOM" id="CLU_012817_4_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220736" evidence="3">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="165" mass="17729" checksum="091A6D739B8D3EF6" modified="2005-12-06" version="1">MLRRSLIFLVLLSAGCVSLDPHYSTPESPIPATLPGAQGQGKAISHDWQQVIHDPRLQQVVTIALNSNRDVQKAIADMDSARALYGQTNASLFPTVNAALSSTRSRSLANGTETTAEADGTVSSFTLDLFGRNQSLSRAARETWLASEFTAQNTRLTLIAEISTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GQ8</accession>
    <name>Q32GQ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GQ8"/>
    <dbReference type="EnsemblBacteria" id="ABB61497">
        <property type="protein sequence ID" value="ABB61497"/>
        <property type="gene ID" value="SDY_1351"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1351"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="YDSAPME"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="263" mass="30654" checksum="D61EA92713696040" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDSAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSYCPPERYGQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GS6</accession>
    <name>Q32GS6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="4 9">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">trpE</name>
        <name evidence="15" type="ordered locus">SDY_1332</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="4 9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001194571.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402970.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GS6"/>
    <dbReference type="STRING" id="300267.SDY_1332"/>
    <dbReference type="EnsemblBacteria" id="ABB61479">
        <property type="protein sequence ID" value="ABB61479"/>
        <property type="gene ID" value="SDY_1332"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1332"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1582"/>
    <dbReference type="HOGENOM" id="CLU_006493_9_4_6"/>
    <dbReference type="OMA" id="AYRSFMN"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005257">
        <property type="entry name" value="Anth_synth_I_TrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF22">
        <property type="entry name" value="PTHR11236:SF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001373">
        <property type="entry name" value="TrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00565">
        <property type="entry name" value="trpE_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="14">
        <location>
            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="13">
        <location>
            <begin position="242"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tryptophan binding" evidence="12">
        <location>
            <begin position="291"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Chorismate binding" evidence="12">
        <location>
            <begin position="328"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Chorismate binding" evidence="12">
        <location>
            <begin position="483"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="291"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="328"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>chorismate</name>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>chorismate</name>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>chorismate</name>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="483"/>
            <end position="485"/>
        </location>
        <ligand>
            <name>chorismate</name>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001373-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001373-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001373-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB61479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="520" mass="57501" checksum="B2882A8E8B12001D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HD2</accession>
    <name>Q32HD2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yecI</name>
        <name evidence="3" type="ordered locus">SDY_1116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000179469.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402764.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HD2"/>
    <dbReference type="SMR" id="Q32HD2"/>
    <dbReference type="STRING" id="300267.SDY_1116"/>
    <dbReference type="EnsemblBacteria" id="ABB61273">
        <property type="protein sequence ID" value="ABB61273"/>
        <property type="gene ID" value="SDY_1116"/>
    </dbReference>
    <dbReference type="GeneID" id="66674210"/>
    <dbReference type="KEGG" id="sdy:SDY_1116"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1314"/>
    <dbReference type="HOGENOM" id="CLU_065681_1_3_6"/>
    <dbReference type="OMA" id="SNVTHMM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="167" mass="18894" checksum="3A5221E7C957A41F" modified="2005-12-06" version="1">MATAGMLLKLNSQMNREFYASNLYLHLSNWCSEQSLNGTATFLRAQAQSNVTQMMRMFNFMKSVGATPIVKAIDVPGEKLNSLEELFQKTMEEYEQRSSTLAQLADEAKELNDDSTVNFLRDLEKEQQHDGLLLQTILDEVRSAKLAGMCPVQTDQHVLNVVSHQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HH8</accession>
    <name>Q32HH8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ipaH_3</name>
        <name evidence="10" type="ordered locus">SDY_1062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LRR-containing bacterial E3 ligase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HH8"/>
    <dbReference type="STRING" id="300267.SDY_1062"/>
    <dbReference type="EnsemblBacteria" id="ABB61227">
        <property type="protein sequence ID" value="ABB61227"/>
        <property type="gene ID" value="SDY_1062"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1062"/>
    <dbReference type="HOGENOM" id="CLU_018533_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029487">
        <property type="entry name" value="NEL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14496">
        <property type="entry name" value="NEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="NEL" evidence="9">
        <location>
            <begin position="145"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="386" mass="44429" checksum="04BB8BC7A6987791" modified="2005-12-06" version="1">MSLEYINVSDNHLFALPELPASLEYINVSDNHLSVLPRLPMSLELLDAARNALEVIPDFPERDDHIIRIFWLNQNRITAIPESILGLSSDSVVNLRENQLSPRIMQTLLQQTAQPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAIAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYPQRVADRLKAEVYWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HI2</accession>
    <name>Q32HI2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HI2"/>
    <dbReference type="EnsemblBacteria" id="ABB61223">
        <property type="protein sequence ID" value="ABB61223"/>
        <property type="gene ID" value="SDY_1058"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1058"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="70" mass="7911" checksum="14F12171D38D4EEE" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITQILMQSDEQNTKKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HI3</accession>
    <name>Q32HI3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0362</name>
        <name evidence="4" type="ordered locus">SDY_1057</name>
        <name evidence="5" type="ordered locus">SDY_1414</name>
        <name evidence="6" type="ordered locus">SDY_1761</name>
        <name evidence="7" type="ordered locus">SDY_2132</name>
        <name evidence="8" type="ordered locus">SDY_2400</name>
        <name evidence="9" type="ordered locus">SDY_2652</name>
        <name evidence="10" type="ordered locus">SDY_3199</name>
        <name evidence="11" type="ordered locus">SDY_3531</name>
        <name evidence="12" type="ordered locus">SDY_3946</name>
        <name evidence="13" type="ordered locus">SDY_4621</name>
    </gene>
    <organism evidence="4 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402065.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402713.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403049.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403369.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403713.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403965.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404194.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404700.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404999.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405371.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405966.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60576">
        <property type="protein sequence ID" value="ABB60576"/>
        <property type="gene ID" value="SDY_0362"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61222">
        <property type="protein sequence ID" value="ABB61222"/>
        <property type="gene ID" value="SDY_1057"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61558">
        <property type="protein sequence ID" value="ABB61558"/>
        <property type="gene ID" value="SDY_1414"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61878">
        <property type="protein sequence ID" value="ABB61878"/>
        <property type="gene ID" value="SDY_1761"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62222">
        <property type="protein sequence ID" value="ABB62222"/>
        <property type="gene ID" value="SDY_2132"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62474">
        <property type="protein sequence ID" value="ABB62474"/>
        <property type="gene ID" value="SDY_2400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62703">
        <property type="protein sequence ID" value="ABB62703"/>
        <property type="gene ID" value="SDY_2652"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63209">
        <property type="protein sequence ID" value="ABB63209"/>
        <property type="gene ID" value="SDY_3199"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63508">
        <property type="protein sequence ID" value="ABB63508"/>
        <property type="gene ID" value="SDY_3531"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63880">
        <property type="protein sequence ID" value="ABB63880"/>
        <property type="gene ID" value="SDY_3946"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64475">
        <property type="protein sequence ID" value="ABB64475"/>
        <property type="gene ID" value="SDY_4621"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0362"/>
    <dbReference type="KEGG" id="sdy:SDY_1057"/>
    <dbReference type="KEGG" id="sdy:SDY_1414"/>
    <dbReference type="KEGG" id="sdy:SDY_1761"/>
    <dbReference type="KEGG" id="sdy:SDY_2132"/>
    <dbReference type="KEGG" id="sdy:SDY_2400"/>
    <dbReference type="KEGG" id="sdy:SDY_2652"/>
    <dbReference type="KEGG" id="sdy:SDY_3199"/>
    <dbReference type="KEGG" id="sdy:SDY_3531"/>
    <dbReference type="KEGG" id="sdy:SDY_3946"/>
    <dbReference type="KEGG" id="sdy:SDY_4621"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1237"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB64475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15322" checksum="E34B644A8DE7EE1B" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HI5</accession>
    <name>Q32HI5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_0374</name>
        <name evidence="4" type="ordered locus">SDY_1055</name>
        <name evidence="5" type="ordered locus">SDY_2288</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402077.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402711.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403856.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60588">
        <property type="protein sequence ID" value="ABB60588"/>
        <property type="gene ID" value="SDY_0374"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61220">
        <property type="protein sequence ID" value="ABB61220"/>
        <property type="gene ID" value="SDY_1055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62365">
        <property type="protein sequence ID" value="ABB62365"/>
        <property type="gene ID" value="SDY_2288"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0374"/>
    <dbReference type="KEGG" id="sdy:SDY_1055"/>
    <dbReference type="KEGG" id="sdy:SDY_2288"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1235"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14956" checksum="0AD9B07D74CEE84E" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLLPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HJ5</accession>
    <name>Q32HJ5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dcm</name>
        <name evidence="10" type="ordered locus">SDY_1045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001157258.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402701.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HJ5"/>
    <dbReference type="STRING" id="300267.SDY_1045"/>
    <dbReference type="REBASE" id="11593">
        <property type="entry name" value="M.SdySDcmP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61210">
        <property type="protein sequence ID" value="ABB61210"/>
        <property type="gene ID" value="SDY_1045"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1045"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1221"/>
    <dbReference type="HOGENOM" id="CLU_006958_0_1_6"/>
    <dbReference type="OMA" id="AGYRKGF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040743">
        <property type="entry name" value="DNA_meth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18284">
        <property type="entry name" value="DNA_meth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_meth_N" evidence="9">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="472" mass="53430" checksum="21F31C82D75FAEEE" modified="2005-12-06" version="1">MQENISVTDSYSTGNAAQAMLEKLLQIYDVKTLVAQLNGVGENHWSAAILKRALANDSAWHRLSEKEFAHLQTLLPKPPAHHPHYAFRFIDLFAGIGGIRRGFESIGGQCVFTSEWNKHAVRTYKANHYCDPATHRFNEDIRDITLSHKEGVSDEAAAEHIRQHIPEHDVLLAGFPCQPFSLAGVSKKNSLGRAHGFACDTQGTLFFDVVRIIDARRPAMFVLENVKNLKSHDQGKTFRIIMQTLDELGYDVADAEDNGPDDPKIIDGKHFLPQHRERIVLVGFRRDLNLKADFTLRDISGCFPAQRVTLAQLLDPMVEAKYILTPVLWKYLYRYAKKHQARGNGFGYGMVYPNNPQSVTRTLSARYYKDGAEILIDRGWDMATGEKDFDDPMNQQHRPRRLTPRECARLMGFEAPGEAKFRIPVSDTQAYRQFGNSVVVPVFAAVAKLLEPKIKQAVALRQQEAQHGRRSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HK6</accession>
    <name>MSRQ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Flavocytochrome MsrQ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msrQ</name>
        <name type="ordered locus">SDY_1034</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="1">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001240091.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402690.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HK6"/>
    <dbReference type="STRING" id="300267.SDY_1034"/>
    <dbReference type="EnsemblBacteria" id="ABB61199">
        <property type="protein sequence ID" value="ABB61199"/>
        <property type="gene ID" value="SDY_1034"/>
    </dbReference>
    <dbReference type="GeneID" id="66674138"/>
    <dbReference type="KEGG" id="sdy:SDY_1034"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1208"/>
    <dbReference type="HOGENOM" id="CLU_080662_1_0_6"/>
    <dbReference type="OMA" id="LHFFWMR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01207">
        <property type="entry name" value="MsrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022837">
        <property type="entry name" value="MsrQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36964">
        <property type="entry name" value="PTHR36964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000085535" description="Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01207"/>
        </source>
    </evidence>
    <sequence length="211" mass="24068" checksum="4BB07AFF858D69BB" modified="2005-12-06" version="1">MRLTAKQVTWLKVCLHLAGLLPFLWLVWAINHGGLGADPVKDIQHFTGRTALKFLLATLLITPLARYAKQPLLIRTRRLLGLWCFAWATLHLTSYALLELGVNNLALLGKELITRPYLTLGIISWVILLALAFTSTQAMQRKLGKHWQQLHNFVYLVAILAPIHYLWSVKIISPQPLIYAGLAVLLLALRYKKLRSLFNRLRKQVHNKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HQ7</accession>
    <name>Q32HQ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yccJ</name>
        <name evidence="1" type="ordered locus">SDY_0979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001143120.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402639.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HQ7"/>
    <dbReference type="STRING" id="300267.SDY_0979"/>
    <dbReference type="EnsemblBacteria" id="ABB61148">
        <property type="protein sequence ID" value="ABB61148"/>
        <property type="gene ID" value="SDY_0979"/>
    </dbReference>
    <dbReference type="GeneID" id="67414111"/>
    <dbReference type="KEGG" id="sdy:SDY_0979"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1138"/>
    <dbReference type="HOGENOM" id="CLU_202423_0_0_6"/>
    <dbReference type="OMA" id="LYWGEET"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025600">
        <property type="entry name" value="YccJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13993">
        <property type="entry name" value="YccJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8524" checksum="6F7108422ED519A5" modified="2005-12-06" version="1">MPTQEAKAHHVGEWASLRNTSPEIAEAIFEVAGYDEKMAEKIWEEGSDEVLVKAFAKTDKDSLFWGEQTIERKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HT3</accession>
    <name>Q32HT3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable Ni/Fe-hydrogenase 1 b-type cytochrome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hyaC</name>
        <name evidence="6" type="ordered locus">SDY_0949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HupC/HyaC/HydC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001186424.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402613.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HT3"/>
    <dbReference type="SMR" id="Q32HT3"/>
    <dbReference type="STRING" id="300267.SDY_0949"/>
    <dbReference type="EnsemblBacteria" id="ABB61122">
        <property type="protein sequence ID" value="ABB61122"/>
        <property type="gene ID" value="SDY_0949"/>
    </dbReference>
    <dbReference type="GeneID" id="66670750"/>
    <dbReference type="KEGG" id="sdy:SDY_0949"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1096"/>
    <dbReference type="HOGENOM" id="CLU_075520_0_0_6"/>
    <dbReference type="OMA" id="FYIAYPF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000516">
        <property type="entry name" value="Ni-dep_Hydgase_cyt-B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00161">
        <property type="entry name" value="NIHGNASECYTB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02125">
        <property type="entry name" value="CytB-hydogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00882">
        <property type="entry name" value="NI_HGENASE_CYTB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00883">
        <property type="entry name" value="NI_HGENASE_CYTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="5">
        <location>
            <begin position="14"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="235" mass="27597" checksum="98048DC800AB02C7" modified="2005-12-06" version="1">MQQKSDNVVSHYVFEAPVRIWHWLTVLCMAVLMVTGYFIGKPLPSVSGEATYLFYMGYIRLIHFSAGMVFTVVLLMRIYWAFVGNRYSRELFIVPVWRKSWWQGVWYEIRWYLFLAKRPSADIGHNPIAQAAMFGYFLMSVFMIITGFALYSEHSQYAIFAPFRYVVEFFYWTGGNSMDIHSWHRLGMWLIGAFVIGHVYMALREDIMSDDTVISTMVNGYRSHKFGKISNKERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HW5</accession>
    <name>Q32HW5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FimH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378623.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402581.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HW5"/>
    <dbReference type="STRING" id="300267.SDY_0914"/>
    <dbReference type="EnsemblBacteria" id="ABB61090">
        <property type="protein sequence ID" value="ABB61090"/>
        <property type="gene ID" value="SDY_0914"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0914"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1060"/>
    <dbReference type="HOGENOM" id="CLU_066608_0_0_6"/>
    <dbReference type="OMA" id="CYNIPAS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000259">
        <property type="entry name" value="Adhesion_dom_fimbrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00419">
        <property type="entry name" value="Fimbrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221131" evidence="1">
        <location>
            <begin position="30"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Fimbrial" evidence="2">
        <location>
            <begin position="210"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="355" mass="37877" checksum="5D1D03E5A8CA7E3B" modified="2005-12-06" version="1">MKNTCSTNWKHHRLFFAAVLMLWCAQTAAYSGQCHTTQGNPYIGVNFGVKTLEEEENTAGVVKDKFYQWNESNDYYVSCDCDKDNVRNGRWAFAADSPLVYLGDNWYKINDYLAAKVLLQVKGSSPTAVPFENVGTGGDTRWHICDPGGQRLGGQGASGNSGSFSLKILQPFVGSVVIPSMALARLFECYNIPAGDSCTTTGTPVLVYYLSGTINSLGSCSVNAGETIEVELGDVFAANFRVVGHKPLGARTAELAIPVRCNTGNAGLVNVNLSLTATTDPSYPQAIKTSCPGVGVVVTDSQNNIISPAGGTLPLSIPDDADSIARMNVYPVSTTGVPPETGRFEATATVRINFD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HZ7</accession>
    <name>CCME_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytochrome c-type biogenesis protein CcmE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytochrome c maturation protein E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heme chaperone CcmE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ccmE</name>
        <name evidence="1" type="synonym">cycJ</name>
        <name type="ordered locus">SDY_0881</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CcmE/CycJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001026418.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402549.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HZ7"/>
    <dbReference type="SMR" id="Q32HZ7"/>
    <dbReference type="STRING" id="300267.SDY_0881"/>
    <dbReference type="EnsemblBacteria" id="ABB61058">
        <property type="protein sequence ID" value="ABB61058"/>
        <property type="gene ID" value="SDY_0881"/>
    </dbReference>
    <dbReference type="GeneID" id="66673908"/>
    <dbReference type="KEGG" id="sdy:SDY_0881"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1016"/>
    <dbReference type="HOGENOM" id="CLU_079503_1_0_6"/>
    <dbReference type="OMA" id="HVEFAVH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017003">
        <property type="term" value="P:protein-heme linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01959">
        <property type="entry name" value="CcmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004329">
        <property type="entry name" value="CcmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036127">
        <property type="entry name" value="CcmE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34128">
        <property type="entry name" value="PTHR34128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03100">
        <property type="entry name" value="CcmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82093">
        <property type="entry name" value="SSF82093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000238866" description="Cytochrome c-type biogenesis protein CcmE">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="30"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="159" mass="17698" checksum="FA0585B8CD6446FC" modified="2005-12-06" version="1">MNIRRKNRLWIACAVLAGLALTIGLVLYALRSNIDLFYTPGEILYGKRETQQMPEVGQRLRVGGMVMPGSVQRDPNSLKVTFTIYDAEGSVDVSYEGILPDLFREGQGVVVQGELEKGNHILAKEVLAKHDENYTPPEVEKAMEANHRRPASVYKDPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I12</accession>
    <name>Q32I12_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yojI</name>
        <name evidence="10" type="ordered locus">SDY_0865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000422221.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402534.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I12"/>
    <dbReference type="STRING" id="300267.SDY_0865"/>
    <dbReference type="EnsemblBacteria" id="ABB61043">
        <property type="protein sequence ID" value="ABB61043"/>
        <property type="gene ID" value="SDY_0865"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0865"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.999"/>
    <dbReference type="HOGENOM" id="CLU_023671_1_0_6"/>
    <dbReference type="OMA" id="GWADTAV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005898">
        <property type="entry name" value="Cyc_pep_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43553:SF11">
        <property type="entry name" value="PTHR43553:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01194">
        <property type="entry name" value="cyc_pep_trnsptr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="15"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="323"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="547" mass="61479" checksum="E842C5B027D77908" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I61</accession>
    <name>Q32I61_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cardiolipin synthase B</fullName>
            <shortName evidence="1">CL synthase</shortName>
            <ecNumber evidence="1">2.7.8.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybhO</name>
        <name evidence="1" type="synonym">clsB</name>
        <name evidence="4" type="ordered locus">SDY_0814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol</text>
            <dbReference type="Rhea" id="RHEA:31451"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000650344.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402485.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I61"/>
    <dbReference type="STRING" id="300267.SDY_0814"/>
    <dbReference type="EnsemblBacteria" id="ABB60996">
        <property type="protein sequence ID" value="ABB60996"/>
        <property type="gene ID" value="SDY_0814"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0814"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.938"/>
    <dbReference type="HOGENOM" id="CLU_038053_0_0_6"/>
    <dbReference type="OMA" id="EYCQRPL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01917">
        <property type="entry name" value="Cardiolipin_synth_ClsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030872">
        <property type="entry name" value="Cardiolipin_synth_ClsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="410" mass="47255" checksum="8D4885F097D5B724" modified="2005-12-06" version="1">MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDEFVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDILQFELENLPGQSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANTYFFPGYRFLHALRKAARRGARIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEANVIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTGQVDPPAQPTMETQDRVETENTGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I98</accession>
    <name>Q32I98_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybiU</name>
        <name evidence="1" type="ordered locus">SDY_0775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000144242.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402448.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I98"/>
    <dbReference type="STRING" id="300267.SDY_0775"/>
    <dbReference type="EnsemblBacteria" id="ABB60959">
        <property type="protein sequence ID" value="ABB60959"/>
        <property type="gene ID" value="SDY_0775"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0775"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.893"/>
    <dbReference type="HOGENOM" id="CLU_011148_1_0_6"/>
    <dbReference type="OMA" id="ISEKWHP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="DUF1479"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="PTHR30613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="DUF1479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="419" mass="46790" checksum="006DAA0E820D91B4" modified="2005-12-06" version="1">MTFSCETLPTDAKAAIREMKAALRGQLGDVQQVFDTLSAKIETRVAEIDALKAQGPPVWPEVSYSDIAAGTVSDATRNEIKRRGCAVIKGHFPREQALAWDRAMLDYLDINHFDDVYKGPGDSFFGSLEASRPEIYPIYWSQAQMQARQSENMAAVQSFLNRLWTSESNGKQWFNPDISVIYPDRIRRRPPGTTSKGLGAHTDSGALERWLLPAYQRVFANVFNGNFDDYDPWDAAHRTDVEEYTVDNTTKCSVFRTFQGWTALSDMLSGQGLLHVVPIPEAMAYVLLRPLLDDVPDDELCGVAPGKVLPISEKWHPLLLKALTSIPEITAGDSVWWHCDVIHSVAPVEIQQGWGNVMYIPAAPMCEKNLSYAHKVKAALEKGASPGDFPREDYETNWEGRFTLADLNIHGKRALGMDV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-03" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ID7</accession>
    <name>RLMC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">23S rRNA (uracil(747)-C(5))-methyltransferase RlmC</fullName>
            <ecNumber evidence="1">2.1.1.189</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA(m5U747)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmC</name>
        <name type="synonym">rumB</name>
        <name type="ordered locus">SDY_0736</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42628"/>
            <dbReference type="Rhea" id="RHEA-COMP:10154"/>
            <dbReference type="Rhea" id="RHEA-COMP:10155"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.189"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.189" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001149702.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402409.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ID7"/>
    <dbReference type="SMR" id="Q32ID7"/>
    <dbReference type="STRING" id="300267.SDY_0736"/>
    <dbReference type="EnsemblBacteria" id="ABB60920">
        <property type="protein sequence ID" value="ABB60920"/>
        <property type="gene ID" value="SDY_0736"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0736"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.850"/>
    <dbReference type="HOGENOM" id="CLU_014689_0_0_6"/>
    <dbReference type="OMA" id="YCGVGGF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070041">
        <property type="term" value="F:rRNA (uridine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01012">
        <property type="entry name" value="23SrRNA_methyltr_RlmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011825">
        <property type="entry name" value="23SrRNA_MeTrfase_RlmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02085">
        <property type="entry name" value="meth_trns_rumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000282019" description="23S rRNA (uracil(747)-C(5))-methyltransferase RlmC">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01012"/>
        </source>
    </evidence>
    <sequence length="375" mass="41842" checksum="29E528BC4AB93384" modified="2005-12-06" version="1">MQCALYDAGRCRSCQWITQPIPEQLSAKTADLKNLLADFPVEEWCAPVSGPEQGFRNKAKMVVSGSVEKPLLGMLHRDGTPEDLCDCPLYPASFAPVFAALKPFIARAGLTPYNVARKRGELKYILLTESQSDGGMMLRFVLRSDTKLAQLRKALPWLHEQLPQLKVITVNIQPVHMAIMEGETEIYLTEHQALAERFNDVPLWIRPQSFFQTNPAVASQLYATARDWVRQLPVTHMWDLFCGVGGFGLHCATPDMQLTGIEIAPEAIACAKQSAAELGLTCLQFQALDSTQFATAQGEVPELVLVNPPRRGIGKPLCDYLSTMAPCFIIYSSCNAQTMAKDIRELPGYRIERVQLFDMFPHTAHYEVLTLQVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IF2</accession>
    <name>Q32IF2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IF2"/>
    <dbReference type="STRING" id="300267.SDY_0721"/>
    <dbReference type="EnsemblBacteria" id="ABB60905">
        <property type="protein sequence ID" value="ABB60905"/>
        <property type="gene ID" value="SDY_0721"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0721"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_11_6"/>
    <dbReference type="OMA" id="IISCQRP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="102"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="174" mass="19915" checksum="08840B26F214FA56" modified="2005-12-06" version="1">MFGVHRSSYRYWKNRPEKPDGRRAVLRSQVLELHGISHGSAGARSIATMATRRGYQMGRWLAGRLMKELGLVSCQQPTHRYKRGGHEHVAIPNYLERQFAVTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKPGGVMFHSEVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IG7</accession>
    <name>Q32IG7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="15">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">galT</name>
        <name evidence="18" type="ordered locus">SDY_0705</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="15"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000191540.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402379.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IG7"/>
    <dbReference type="STRING" id="300267.SDY_0705"/>
    <dbReference type="EnsemblBacteria" id="ABB60890">
        <property type="protein sequence ID" value="ABB60890"/>
        <property type="gene ID" value="SDY_0705"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0705"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.816"/>
    <dbReference type="HOGENOM" id="CLU_029960_0_0_6"/>
    <dbReference type="OMA" id="HAIYYPP"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 15" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="16">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="17">
        <location>
            <begin position="183"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-alpha-D-glucose binding; shared with dimeric partner" evidence="11">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-alpha-D-glucose binding" evidence="11">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-alpha-D-glucose binding" evidence="11">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-alpha-D-glucose binding; shared with dimeric partner" evidence="11">
        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-alpha-D-glucose binding; shared with dimeric partner" evidence="11">
        <location>
            <begin position="316"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 14">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB60890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="348" mass="39706" checksum="E35347B0ACDCD773" modified="2005-12-06" version="1">MTQFNPVDHPHRRYNPLTGQWILVSPHRAKRPWQGEQETPAKQVLPAHDPDCFLCAGNVRVTGDKNPDYTGAYVFTNDFAALMSDTPDAPESNDPLMRCQRARGTSRVICFSPDHSKTLPELSVAALTEIVKTWQEQTAELGKTYPWVQVFENKGAAMGCSNPHPHGQVWANSFLPNEAEREDRLQKEYFAEQKSPMLVDYVQRELADGSRTVVETEHWLAVVPYWAAWPFETLLLPKAHVLRITDLTDAQRSDLALALKKLTSRYDNLFQCSFPYSMGWHGAPFNGEENQHWQLHAHFYPPLLRSATVRKFMVGYEMLAETQRDLTAEQAAERLRAVSDIHFRESGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IK9</accession>
    <name>Q32IK9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Succinate dehydrogenase hydrophobic membrane anchor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sdhD</name>
        <name evidence="10" type="ordered locus">SDY_0660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Membrane-anchoring subunit of succinate dehydrogenase (SDH).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="8">The heme is bound between the two transmembrane subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000254365.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402337.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IK9"/>
    <dbReference type="SMR" id="Q32IK9"/>
    <dbReference type="STRING" id="300267.SDY_0660"/>
    <dbReference type="EnsemblBacteria" id="ABB60848">
        <property type="protein sequence ID" value="ABB60848"/>
        <property type="gene ID" value="SDY_0660"/>
    </dbReference>
    <dbReference type="GeneID" id="67413763"/>
    <dbReference type="KEGG" id="sdy:SDY_0660"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.771"/>
    <dbReference type="HOGENOM" id="CLU_151315_2_0_6"/>
    <dbReference type="OMA" id="QWMKVLT"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014312">
        <property type="entry name" value="Succ_DH_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38689">
        <property type="entry name" value="PTHR38689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000169">
        <property type="entry name" value="SDH_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02968">
        <property type="entry name" value="succ_dehyd_anc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared with second transmembrane subunit</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000169-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="115" mass="12868" checksum="5CFD0104CB3CC2F9" modified="2005-12-06" version="1">MVSNASALGRNGVHDFILVRATAIVLTLYIIYMVGFFATSGELTYEVWIGFFASAFTKVFTLLALFSILIHAWIGMWQVLTDYVKPLALRLMLQLVIVVALVVYVIYGFVVVWGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IL9</accession>
    <name>END8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DNA glycosylase/AP lyase Nei</fullName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
            <ecNumber evidence="1">4.2.99.18</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">DNA-(apurinic or apyrimidinic site) lyase Nei</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Endonuclease VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nei</name>
        <name type="ordered locus">SDY_0649</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EC" id="4.2.99.18" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001114030.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402327.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IL9"/>
    <dbReference type="SMR" id="Q32IL9"/>
    <dbReference type="STRING" id="300267.SDY_0649"/>
    <dbReference type="EnsemblBacteria" id="ABB60838">
        <property type="protein sequence ID" value="ABB60838"/>
        <property type="gene ID" value="SDY_0649"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0649"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.757"/>
    <dbReference type="HOGENOM" id="CLU_038423_2_2_6"/>
    <dbReference type="OMA" id="TYWCPRC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08965">
        <property type="entry name" value="EcNei-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01253">
        <property type="entry name" value="Endonuclease_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044091">
        <property type="entry name" value="EcNei-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023713">
        <property type="entry name" value="Endonuclease-VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_1000067210" description="Endonuclease 8">
        <location>
            <begin position="2"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="FPG-type" evidence="1">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01253"/>
        </source>
    </evidence>
    <sequence length="263" mass="29841" checksum="89E58FDDF6E0707E" modified="2005-12-06" version="1">MPEGPEIRRAADNLEAAIKGKPLTDVWFAFPQLKTYQSQLIGQHVTHVETRGKALLTHFSNDLTLYSHNQLYGVWRVVDTGEESQTTRVLRVKLQTADKTILLYSASDIEMLTPEQLTMHPFLQRVGPDVLDPNLTPEVVKERLLSPRFRNRQFAGLLLDQAFLAGLGNYLRVEILWQVGLTGNHKAKDLNAAQLDALAHALLDIPRFSYATRGQVDENKHHGALFRFKVFHRDGELCERCGGIIEKTTLSSRPFYWCPGCQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J14</accession>
    <name>Q32J14_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0414</name>
        <name evidence="4" type="ordered locus">SDY_0486</name>
        <name evidence="5" type="ordered locus">SDY_3638</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402114.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402182.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0414"/>
    <dbReference type="EnsemblBacteria" id="ABB60625">
        <property type="protein sequence ID" value="ABB60625"/>
        <property type="gene ID" value="SDY_0414"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60693">
        <property type="protein sequence ID" value="ABB60693"/>
        <property type="gene ID" value="SDY_0486"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63606">
        <property type="protein sequence ID" value="ABB63606"/>
        <property type="gene ID" value="SDY_3638"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0414"/>
    <dbReference type="KEGG" id="sdy:SDY_0486"/>
    <dbReference type="KEGG" id="sdy:SDY_3638"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.493"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15392" checksum="0908AFFE87513275" modified="2005-12-06" version="1">MVLICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JF2</accession>
    <name>Q32JF2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate regulon transcriptional regulatory protein PhoB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">phoB</name>
        <name evidence="9" type="ordered locus">SDY_0338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000113934.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402044.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JF2"/>
    <dbReference type="SMR" id="Q32JF2"/>
    <dbReference type="STRING" id="300267.SDY_0338"/>
    <dbReference type="EnsemblBacteria" id="ABB60555">
        <property type="protein sequence ID" value="ABB60555"/>
        <property type="gene ID" value="SDY_0338"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0338"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.392"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_6"/>
    <dbReference type="OMA" id="IDRVWGS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011879">
        <property type="entry name" value="Sig_transdc_resp-reg_PhoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02154">
        <property type="entry name" value="PhoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="229" mass="26463" checksum="EB5DA09984059D93" modified="2005-12-06" version="1">MARRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTRDIPVVMLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVIEMQGLSLDPTSHRVMTGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGGHDRMVQTVRGTGYRFSTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JW5</accession>
    <name>Q32JW5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">folK</name>
        <name evidence="14" type="ordered locus">SDY_0158</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000215128.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401881.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JW5"/>
    <dbReference type="STRING" id="300267.SDY_0158"/>
    <dbReference type="EnsemblBacteria" id="ABB60392">
        <property type="protein sequence ID" value="ABB60392"/>
        <property type="gene ID" value="SDY_0158"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0158"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.181"/>
    <dbReference type="HOGENOM" id="CLU_097916_0_1_6"/>
    <dbReference type="OMA" id="QVILRQN"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="13">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB60392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="159" mass="18019" checksum="F79E7DDF44CBF57A" modified="2005-12-06" version="1">MTVAYIAIGSNLASPLEQVNAALKALGDIPESHILAVSSFYRTPPLGPQDQPDYLNAAVALETSLAPEELLNHTQRIELQQGRVRKAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGETLREILHARKFSKLNQW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JZ5</accession>
    <name>SECM_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Secretion monitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secM</name>
        <name type="ordered locus">SDY_0127</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
        <text evidence="1">The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecM family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60362" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60362.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000014313.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401851.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JZ5"/>
    <dbReference type="STRING" id="300267.SDY_0127"/>
    <dbReference type="EnsemblBacteria" id="ABB60362">
        <property type="protein sequence ID" value="ABB60362"/>
        <property type="gene ID" value="SDY_0127"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0127"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.146"/>
    <dbReference type="HOGENOM" id="CLU_108853_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01332">
        <property type="entry name" value="SecM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009502">
        <property type="entry name" value="SecM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06558">
        <property type="entry name" value="SecM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004572">
        <property type="entry name" value="SecM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000314449" description="Secretion monitor">
        <location>
            <begin position="38"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="170" mass="18846" checksum="C46AE215AE981269" modified="2008-01-15" version="2" precursor="true">MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRHPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K09</accession>
    <name>FTSL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein FtsL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ftsL</name>
        <name type="ordered locus">SDY_0113</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of a complex composed of FtsB, FtsL and FtsQ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes to the division septum where it forms a ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000625658.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401837.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K09"/>
    <dbReference type="SMR" id="Q32K09"/>
    <dbReference type="STRING" id="300267.SDY_0113"/>
    <dbReference type="EnsemblBacteria" id="ABB60348">
        <property type="protein sequence ID" value="ABB60348"/>
        <property type="gene ID" value="SDY_0113"/>
    </dbReference>
    <dbReference type="GeneID" id="67416156"/>
    <dbReference type="KEGG" id="sdy:SDY_0113"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.132"/>
    <dbReference type="HOGENOM" id="CLU_156524_2_0_6"/>
    <dbReference type="OMA" id="DLWHHKW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00910">
        <property type="entry name" value="FtsL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011922">
        <property type="entry name" value="Cell_div_FtsL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37479">
        <property type="entry name" value="PTHR37479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04999">
        <property type="entry name" value="FtsL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02209">
        <property type="entry name" value="ftsL_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000414569" description="Cell division protein FtsL">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00910"/>
        </source>
    </evidence>
    <sequence length="121" mass="13627" checksum="6DD5DF7B2ECB7090" modified="2005-12-06" version="1">MISRVTEALSKVKGSMGSHERHALPGVIGDDLLRFGKLPLCLFICIILTAVTVVTTAHHTRLLTAQREQLVLERDALDIEWRNLILEENALGDHSRVERIATEKLQMQHVDPSQENIVVQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K41</accession>
    <name>SURA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone SurA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase SurA</fullName>
            <shortName evidence="1">PPIase SurA</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Rotamase SurA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">surA</name>
        <name type="ordered locus">SDY_0078</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
        <text evidence="1">Is capable of associating with the outer membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000800471.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401805.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K41"/>
    <dbReference type="SMR" id="Q32K41"/>
    <dbReference type="STRING" id="300267.SDY_0078"/>
    <dbReference type="PRIDE" id="Q32K41"/>
    <dbReference type="EnsemblBacteria" id="ABB60316">
        <property type="protein sequence ID" value="ABB60316"/>
        <property type="gene ID" value="SDY_0078"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0078"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.88"/>
    <dbReference type="HOGENOM" id="CLU_034646_11_0_6"/>
    <dbReference type="OMA" id="EGGDMGW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01183">
        <property type="entry name" value="Chaperone_SurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023034">
        <property type="entry name" value="PPIase_SurA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015391">
        <property type="entry name" value="SurA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09312">
        <property type="entry name" value="SurA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000270040" description="Chaperone SurA">
        <location>
            <begin position="21"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC 1" evidence="1">
        <location>
            <begin position="171"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC 2" evidence="1">
        <location>
            <begin position="282"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01183"/>
        </source>
    </evidence>
    <sequence length="428" mass="47257" checksum="8C5F933DCAB26F90" modified="2005-12-06" version="1" precursor="true">MKNWKTLLLGIAMIANTSFAAPQVVDKVAAVVNNGVVLESDVDGLMQSVKLNAAQARQQLPDDATLRHQIMERLIMDQIILQMGQKMGVKISDEQLDQAIANIAKQNNMTLNQMRSRLAYDGLNYNTYRNQIRKEMIISEVRNNEVRRRITILPQEVESLAQQVGNQNDASTELNLSHILIPLPENPTSDQVNEAESQARAIVDQARNGADFGKLAIAHSADQQALNGGQMGWGRIQELPGIFAQALSTAKKGDIVGPIRSGVGFHILKVNDLRGESKNISVTEVHARHILLKPSPIMTDEQARVKLEQIAADIKSGKTTFAAAAKEFSQDPGSANQGGDLGWATADIFDPAFRDALTRLNKGQMSAPVHSSFGWHLIELLDTRNVDKTDAAQKDRAYRMLMNRKFSEEAASWMQEQRASAYVKILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K63</accession>
    <name>Q32K63_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator of cai operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">caiF</name>
        <name evidence="1" type="ordered locus">SDY_0056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K63"/>
    <dbReference type="STRING" id="300267.SDY_0056"/>
    <dbReference type="EnsemblBacteria" id="ABB60294">
        <property type="protein sequence ID" value="ABB60294"/>
        <property type="gene ID" value="SDY_0056"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0056"/>
    <dbReference type="HOGENOM" id="CLU_144191_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020357">
        <property type="entry name" value="Tscrpt_reg_CaiF/GrlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07180">
        <property type="entry name" value="CaiF_GrlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="153" mass="17703" checksum="0C7A64B83D9141CF" modified="2005-12-06" version="1">MKLHTIDISTILIWPCLIASKRVIARLLICETGVRMCEGYVEKPLYLLIAEWMMAENRWVIAREISIHFDIEHSKAVNTLTYILSEVTKISCEVKMIPNKLEGRGCQCQRLVKVVDIDEQIYARLRNNSREKLVGVRKTPRIPAVPLTELNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KB1</accession>
    <name>Q32KB1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inner membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yaaJ</name>
        <name evidence="9" type="ordered locus">SDY_0007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KB1"/>
    <dbReference type="STRING" id="300267.SDY_0007"/>
    <dbReference type="EnsemblBacteria" id="ABB60247">
        <property type="protein sequence ID" value="ABB60247"/>
        <property type="gene ID" value="SDY_0007"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0007"/>
    <dbReference type="HOGENOM" id="CLU_024867_0_1_6"/>
    <dbReference type="OMA" id="PMMALFY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="400" mass="43170" checksum="31D655615D149AE0" modified="2005-12-06" version="1">MPDFFSFINSVLWGSVMIYLLFGAGCWFTFRTGFVQFRYIRQFGKSLKNSIHPQPGGLTSFQSLCTSLAARVGSGNLAGVALAITAGGPGAVFLMWVAAFIGMATSFAECSLAQLYKERDVNGQFRGGPAWYMARGLGMRWMGVLFAVFLLIAYGIIFSGVQANAVARALSFSFDFPPLVTGIILAVFALLAITRGLHGVARLMQGFVPLMAIIWVLTSLVICVINIGQLPHVIWSIFESAFGWQEAAGGAAGYTLNQAITNGFQRSMFSNEAGMGSTPNAAAASWPPHPAAQGIVQMIGIFIDTLVICTASAMLILLAGNGTTYMPLEGIQLIQKAMRVLMGSWGAEFVTLVVILFAFSSIVANYIYAENNLFFLRLNNPKAIWCLRICTFQRSSAAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-05-15" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A4SH28</accession>
    <name>A4SH28_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RfpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfpA</name>
        <name evidence="2" type="ordered locus">SDY_PA05</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD197_spA</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD197_spA</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000640">
        <property type="protein sequence ID" value="ABO87499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001139948.1">
        <property type="nucleotide sequence ID" value="NC_009344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A4SH28"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABO87499">
        <property type="protein sequence ID" value="ABO87499"/>
        <property type="gene ID" value="SDY_PA05"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_PA05"/>
    <dbReference type="HOGENOM" id="CLU_025996_0_3_6"/>
    <dbReference type="OMA" id="DADDAWH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD197_spA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABO87499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="196" mass="22666" checksum="72FF5417DC4E5242" modified="2007-05-15" version="1">MKNHKVSIIIPCFNNGKTIERCVLSALKQTHRNIEIICINDGPSDNSWNILKKLSSLYGNVFAFNNEDNSGPSFSRIKGVSLSTGHFLSFLDADDYWHPKKLELQLSFINDENLDFLGSTCSIGEKNNQEINQGIKKEHLKLKIISFNMMLFKNYFQTPAVIMKRDIFIPFNENQRFSEDYMSWLVIVYNKKTNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q326R5</accession>
    <name>Q326R5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MxiL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mxiL</name>
        <name evidence="1" type="ordered locus">SDY_P180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000609864.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406181.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326R5"/>
    <dbReference type="EnsemblBacteria" id="ABB64693">
        <property type="protein sequence ID" value="ABB64693"/>
        <property type="gene ID" value="SDY_P180"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P180"/>
    <dbReference type="HOGENOM" id="CLU_1884377_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="15585" checksum="A9814DCEFDCB2662" modified="2005-12-06" version="1">MINQINASNALQQRLNSEELVNLNDRLSSSQSLDEDIIYEIMQYFSQSELNPIDNDELHNKIEQLFNSRFPYLTAAQKSSLLNKLIDANQYVDLHEGFYASLSIYNNINFYIKTTTFDSLISVFEAGRDADDSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q326U5</accession>
    <name>Q326U5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011379008.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406151.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326U5"/>
    <dbReference type="EnsemblBacteria" id="ABB64663">
        <property type="protein sequence ID" value="ABB64663"/>
        <property type="gene ID" value="SDY_P150"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P150"/>
    <dbReference type="HOGENOM" id="CLU_2994227_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="57" mass="6563" checksum="93924F647678D3C1" modified="2005-12-06" version="1">MDSINVRFSSPPQDSCLLLYDSMEFKLDLIEKSYQLGACVAQLAREYGINDNLLFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q327A9</accession>
    <name>Q327A9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406087.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327A9"/>
    <dbReference type="EnsemblBacteria" id="ABB64599">
        <property type="protein sequence ID" value="ABB64599"/>
        <property type="gene ID" value="SDY_P086"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P086"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5636"/>
    <dbReference type="HOGENOM" id="CLU_193845_0_0_6"/>
    <dbReference type="OMA" id="DYLRWGA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="70" mass="7529" checksum="5B77209AE615C6C5" modified="2005-12-06" version="1">MEPVYVILNALLDSGRFTRKLILLGLSGSFSYIFGSIVATLGMGLVVDYLGCGATFIVLILSLFLPSFSH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q327K0</accession>
    <name>GPMB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable phosphoglycerate mutase GpmB</fullName>
            <ecNumber evidence="1">5.4.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PGAM</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoglyceromutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmB</name>
        <name type="ordered locus">SDY_4656</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. GpmB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000942357.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405996.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327K0"/>
    <dbReference type="SMR" id="Q327K0"/>
    <dbReference type="STRING" id="300267.SDY_4656"/>
    <dbReference type="EnsemblBacteria" id="ABB64505">
        <property type="protein sequence ID" value="ABB64505"/>
        <property type="gene ID" value="SDY_4656"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4656"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5518"/>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_6"/>
    <dbReference type="OMA" id="TEWNVAR"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01040">
        <property type="entry name" value="PGAM_GpmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023086">
        <property type="entry name" value="Phosphoglycerate_mutase_GpmB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000064132" description="Probable phosphoglycerate mutase GpmB">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01040"/>
        </source>
    </evidence>
    <sequence length="215" mass="24040" checksum="73F376D42F09F778" modified="2005-12-06" version="1">MLQVYLVRHGETQWNAERRIQGQSDSPLTAKGEQQAMQVATRAKELGITHIISSDLGRTRRTVEIIAQACGCDIIFDSRLRELNMGVLEKSHIDSLTEEEENWRRQLVNGTVDGRIPEGESMQELSDRVNAALESCRDLPQGSRPLLVSHGIALGCLVSTILGLPAWAERRLRLRNCSISRVDYQESLWLSSGWVVETAGDISHLDAPALDELQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q327M5</accession>
    <name>Q327M5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase III subunit psi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">holD</name>
        <name evidence="2" type="ordered locus">SDY_4631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000204018.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405971.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327M5"/>
    <dbReference type="STRING" id="300267.SDY_4631"/>
    <dbReference type="EnsemblBacteria" id="ABB64480">
        <property type="protein sequence ID" value="ABB64480"/>
        <property type="gene ID" value="SDY_4631"/>
    </dbReference>
    <dbReference type="GeneID" id="66671741"/>
    <dbReference type="KEGG" id="sdy:SDY_4631"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5489"/>
    <dbReference type="HOGENOM" id="CLU_132082_0_0_6"/>
    <dbReference type="OMA" id="QICAHEH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004615">
        <property type="entry name" value="DNA_pol_III_psi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036654">
        <property type="entry name" value="DNA_pol_III_psi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018382">
        <property type="entry name" value="DNA_pol_III_psi_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03603">
        <property type="entry name" value="DNA_III_psi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029225">
        <property type="entry name" value="DNA_pol_III_psi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102220">
        <property type="entry name" value="SSF102220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00664">
        <property type="entry name" value="DNA_III_psi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR029225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="137" mass="15207" checksum="116956210E7EF125" modified="2005-12-06" version="1">MTSRRDWQLQQLGITQWSLRRPGALQGEIAIAIPAHVRLVMVANDLPALTDPLVSDVLRALTVSPDQVLQLTPEKIAMLPQGSRCNSWRLGTDEPLSLEGAQVASPALTELRANPTARAALWQQICTYEHDFFPRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q327P5</accession>
    <name>Q327P5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjiS</name>
        <name evidence="1" type="ordered locus">SDY_4602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000394281.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405951.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327P5"/>
    <dbReference type="STRING" id="300267.SDY_4602"/>
    <dbReference type="EnsemblBacteria" id="ABB64460">
        <property type="protein sequence ID" value="ABB64460"/>
        <property type="gene ID" value="SDY_4602"/>
    </dbReference>
    <dbReference type="GeneID" id="60901916"/>
    <dbReference type="KEGG" id="sdy:SDY_4602"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5454"/>
    <dbReference type="HOGENOM" id="CLU_201670_0_0_6"/>
    <dbReference type="OMA" id="YRINRTR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009506">
        <property type="entry name" value="DUF1127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06568">
        <property type="entry name" value="DUF1127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="54" mass="6737" checksum="9AF4912B935D856C" modified="2005-12-06" version="1">MEFHENRAKAPFIGLVQLWQAVRRWRRQMQTRRVLQQMSDERLRDIGLRREDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q327T9</accession>
    <name>Q327T9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AsmA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yhjG</name>
        <name evidence="4" type="ordered locus">SDY_4544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405907.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327T9"/>
    <dbReference type="STRING" id="300267.SDY_4544"/>
    <dbReference type="EnsemblBacteria" id="ABB64416">
        <property type="protein sequence ID" value="ABB64416"/>
        <property type="gene ID" value="SDY_4544"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4544"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5372"/>
    <dbReference type="HOGENOM" id="CLU_017234_1_1_6"/>
    <dbReference type="OMA" id="AWVPWPH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007844">
        <property type="entry name" value="AsmA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05170">
        <property type="entry name" value="AsmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="691" mass="75146" checksum="1A44050DE43942AB" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q328C0</accession>
    <name>Q328C0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ytfK</name>
        <name evidence="1" type="ordered locus">SDY_4454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405826.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328C0"/>
    <dbReference type="STRING" id="300267.SDY_4454"/>
    <dbReference type="EnsemblBacteria" id="ABB64335">
        <property type="protein sequence ID" value="ABB64335"/>
        <property type="gene ID" value="SDY_4454"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4454"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5254"/>
    <dbReference type="HOGENOM" id="CLU_188461_0_0_6"/>
    <dbReference type="OMA" id="HFNVMSE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009491">
        <property type="entry name" value="DUF1107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06526">
        <property type="entry name" value="DUF1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="9635" checksum="4240ED5DE1B7E983" modified="2005-12-06" version="1">MAPHRRNTQQEITMKIFQRYNPLQVAKYVKILFRGRLYIKDVGAFEFDKGKILIPKVKDKLHLSVMSEVNRQVMRLQTEMA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-03-21" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q328E3</accession>
    <name>QUEG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epoxyqueuosine reductase</fullName>
            <ecNumber evidence="1">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queG</name>
        <name type="ordered locus">SDY_4425</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001294194.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405803.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328E3"/>
    <dbReference type="SMR" id="Q328E3"/>
    <dbReference type="STRING" id="300267.SDY_4425"/>
    <dbReference type="EnsemblBacteria" id="ABB64312">
        <property type="protein sequence ID" value="ABB64312"/>
        <property type="gene ID" value="SDY_4425"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4425"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5227"/>
    <dbReference type="HOGENOM" id="CLU_030790_0_1_6"/>
    <dbReference type="OMA" id="ICDTDLS"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00916">
        <property type="entry name" value="QueG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013542">
        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08331">
        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00276">
        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000416081" description="Epoxyqueuosine reductase">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00916"/>
        </source>
    </evidence>
    <sequence length="379" mass="43038" checksum="3263722CC43AF77C" modified="2005-12-06" version="1">MSEPLDLNQLAHKIKQWGLELGFQQVGITDTDLSESEPKLQAWLDKQYHGEMDWMARHGMLRARPHELLPGTLRVISVRMNYLPANAAFASTLKNPKLGYVSRYALGRDYHKLLRNRLKKLGEMIQQHCVSLNFRPFVDSAPILERPLAEKAGLGWTGKHSLILNREAGSFFFLGELLVDIPLPVDQPVEEGCGKCVACMTICPTGAIVEPYTVDARRCISYLTIELEGAIPEELRPLMGNRIYGCDDCQLICPWNRYSQLTTEDDFSPRKPLHAPELIELFAWSEEKFLKVTEGSAIRRIGHLRWLRNIAVALGNAPWDETILAALESRKGEHPLLDEHIAWAIAQQIERRNACIVEVQLPKKQRLVRVIEKGLPRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q328F3</accession>
    <name>Q328F3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HflK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hflK</name>
        <name evidence="8" type="ordered locus">SDY_4415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">HflC and HflK could encode or regulate a protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">HflC and HflK may interact to form a multimeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000312478.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405793.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328F3"/>
    <dbReference type="STRING" id="300267.SDY_4415"/>
    <dbReference type="EnsemblBacteria" id="ABB64302">
        <property type="protein sequence ID" value="ABB64302"/>
        <property type="gene ID" value="SDY_4415"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4415"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5213"/>
    <dbReference type="HOGENOM" id="CLU_039173_1_0_6"/>
    <dbReference type="OMA" id="WNEPGGN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03404">
        <property type="entry name" value="SPFH_HflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020980">
        <property type="entry name" value="Membrane_HflK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12221">
        <property type="entry name" value="HflK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01933">
        <property type="entry name" value="hflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="7">
        <location>
            <begin position="95"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="419" mass="45662" checksum="DAA9BE2E56ADB3D4" modified="2005-12-06" version="1">MAWNQPGNNGQDRDPWGSSKPGGNSEGNGNKGGRDQGPPDLDDIFRKLSKKLGGLGGGKGTGSGGGSSSQGPRPQLGGRVVTIAAAAIFIIWAASGFYTIKEAERGVVTRFGKFSHLVEPGLNWKPTFIDEVKPVNVEAVRELAASGVMLTSDENVVRVEMNVQYRVTNPEKYLYRVTSPDDSLRQATDSALRGVIGKYTMDRILTEGRTVIRSDTQRELEETIRPYDMGITLLDVNFQAARPPEEVKAAFDDAIAARENEQQYIREAEAYTNEVQPRANGQAQRILEEARAYKAQTILEAQGEVARFAKLLPEYKAAPEITRERLYIETMEKVLGNTRKVLVNDKGGNLMVLPLDQMLKGGNAPAAKSDNGASNLLRLPPASSSTTSGASNTSSTSQGDIMDQRRANAQRNDYQRQGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q328J7</accession>
    <name>RS18_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsR</name>
        <name type="ordered locus">SDY_4371</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000135199.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405749.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328J7"/>
    <dbReference type="SMR" id="Q328J7"/>
    <dbReference type="STRING" id="300267.SDY_4371"/>
    <dbReference type="EnsemblBacteria" id="ABB64258">
        <property type="protein sequence ID" value="ABB64258"/>
        <property type="gene ID" value="SDY_4371"/>
    </dbReference>
    <dbReference type="GeneID" id="9735149"/>
    <dbReference type="KEGG" id="sdy:SDY_4371"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5160"/>
    <dbReference type="HOGENOM" id="CLU_148710_2_3_6"/>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="PRO" id="PR:Q328J7"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000003611" description="30S ribosomal protein S18">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <sequence length="75" mass="8986" checksum="AB2E8288901B73B8" modified="2005-12-06" version="1">MARYFRRRKFCRFTAEGVQEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARAIKRARYLSLLPYTDRHQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Y9</accession>
    <name>SELA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-seryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="1">2.9.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Selenocysteine synthase</fullName>
            <shortName evidence="1">Sec synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">selA</name>
        <name type="ordered locus">SDY_4212</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22728"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodecamer; pentamer of dimers. Binds only one seryl-tRNA(Sec) per dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SelA family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000206268.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405607.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Y9"/>
    <dbReference type="SMR" id="Q328Y9"/>
    <dbReference type="STRING" id="300267.SDY_4212"/>
    <dbReference type="EnsemblBacteria" id="ABB64116">
        <property type="protein sequence ID" value="ABB64116"/>
        <property type="gene ID" value="SDY_4212"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4212"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4952"/>
    <dbReference type="HOGENOM" id="CLU_038142_1_0_6"/>
    <dbReference type="OMA" id="GATNRTH"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004125">
        <property type="term" value="F:L-seryl-tRNASec selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00423">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004534">
        <property type="entry name" value="SelA_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025862">
        <property type="entry name" value="SelA_trans_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12390">
        <property type="entry name" value="Se-cys_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00474">
        <property type="entry name" value="selA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0711">Selenium</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000050382" description="L-seryl-tRNA(Sec) selenium transferase">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00423"/>
        </source>
    </evidence>
    <sequence length="463" mass="50739" checksum="DDBF8A781DC48E0E" modified="2005-12-06" version="1">MTTETRSLYSQLPAIDRLLRDSSFLSLRDTYGHTRVVELLRQMLDEAREVIRDSQTLPTWCENWAQEVDARLTKEAQSALRPVINLTGTVLHTNLGRALQAEAAVEAVAQAMRSPVTLEYDLDDAGRGHRDRALAQLLCRITGVEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEIGGSFRIPDVMRQAGCTLHEVGTTNRTHANDYRQAVNENTALLMKVHTSNYSIQGFTKAIDEAELVALGKELDVPVVTDLGSGSLVDLSQYGLPKEPMPQELIAAGVSLVSFSGDKLLGGPQAGIIVGKKEMIARLQSHPLKRALRADKMTLAALEATLRLYLHPEALSEKLPTLRLLTRSAEVIQIQAQRLQAPLAAHYGAEFAVQVMPCLSQIGSGSLPVDRLPSAALTFTPHDGRGSHLESLAARWRELPVPVIGRIYDGRLWLDLRCLEDEQRFLEMLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q329A1</accession>
    <name>Q329A1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane/transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yieG</name>
        <name evidence="8" type="ordered locus">SDY_4199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000082692.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405595.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329A1"/>
    <dbReference type="STRING" id="300267.SDY_4199"/>
    <dbReference type="EnsemblBacteria" id="ABB64104">
        <property type="protein sequence ID" value="ABB64104"/>
        <property type="gene ID" value="SDY_4199"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4199"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4938"/>
    <dbReference type="HOGENOM" id="CLU_024508_0_1_6"/>
    <dbReference type="OMA" id="RKGSYFF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="445" mass="46774" checksum="439DFB98CDB289EF" modified="2005-12-06" version="1">MSQQHTTQASGQGMLERVFKLREHGTTARTEVIAGFTTFLTMVYIVFVNPQILGVAGMDTSAVFVTTCLIAAFGSIMMGLFANLPVALAPAMGLNAFFAFVVVQAMGLPWQVGMGAIFWGAIGLLLLTIFRVRYWMIANIPVSLRVGITSGIGLFIGMMGLKNAGVIVANPETLVSIGNLTSHSVLLGILGFFIIAILASCNIHAAVLVSIVVTTLLGWMLGDVHYNGIVSAPPSVMTVVGHVDLAGSFNLGLAGVIFSFMLVNLFDSSGTLIGVTDKAGLADEKGKFPRMKQALYVDSISSVTGSFIGTSSVTAYIESSSGVSVGGRTGLTAVVVGLLFLLVIFLSPLAGMVPGYAAAGALIYVGVLMTSSLARVNWQDLTESVPAFITAVMMPFSFSITEGIALGFISYCVMKIGTGRLRDLSPCVIIVALLFILKIVFIDAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q329G7</accession>
    <name>RBSA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose import ATP-binding protein RbsA</fullName>
            <ecNumber evidence="1">7.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbsA</name>
        <name type="ordered locus">SDY_4128</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-ribose(out) + H2O = ADP + D-ribose(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29903"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.5.2.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of an ATP-binding protein (RbsA), two transmembrane proteins (RbsC) and a solute-binding protein (RbsB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001089404.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405529.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329G7"/>
    <dbReference type="SMR" id="Q329G7"/>
    <dbReference type="STRING" id="300267.SDY_4128"/>
    <dbReference type="EnsemblBacteria" id="ABB64038">
        <property type="protein sequence ID" value="ABB64038"/>
        <property type="gene ID" value="SDY_4128"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4128"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4852"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_6"/>
    <dbReference type="OMA" id="RIDHKAT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015611">
        <property type="term" value="F:ABC-type D-ribose transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51254">
        <property type="entry name" value="RBSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000261102" description="Ribose import ATP-binding protein RbsA">
        <location>
            <begin position="1"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="1">
        <location>
            <begin position="250"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01716"/>
        </source>
    </evidence>
    <sequence length="495" mass="54032" checksum="2FFB7114B93EF276" modified="2005-12-06" version="1">MNSTPVLEMRNIAKAFGKFYALKGVDLTVYPSENHALMGENGAGKSTLMKVLAGAYTATSGEILIDGKPFHIRTQKDALSAGITLIYQEMQLAPNLSVAENISLGSELSHGGLVQRKEMLVQAQKVIDRLGAQFNASDKVMTLTIAEQQQVEIARALHRNSRILVMDEPTAALSSRETHRLFELIMRLRDEGMAIIYISHRMAEVYELSDRVSVLRDGQYVGSLTRDNLNAGELVRMMVGRPLSDLFNKERDIPLGKARLNVHHLTDGGKVQPSSLLVRSGKIVGLAGLVGAGRSELAQLIFGVRKATGGMIEVDGEPVVIHSPREAIDLGIGFLTENRKEQGLFLEMAAAENITMATLERDARWEAQTISDDAIKLLNIRVPHAQVRAGGLSGGNQQKMLISRWVAIGPRILLLDEPTRGVDVGAKSEIYRIMNEMARKGVAILMISSELPEIVGMSDRVYVMHEGSIAGELNGKNITQENIMTLATGVNDAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q329J1</accession>
    <name>Q329J1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">basS</name>
        <name evidence="12" type="ordered locus">SDY_4101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405505.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329J1"/>
    <dbReference type="STRING" id="300267.SDY_4101"/>
    <dbReference type="EnsemblBacteria" id="ABB64014">
        <property type="protein sequence ID" value="ABB64014"/>
        <property type="gene ID" value="SDY_4101"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4101"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4824"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_37_6"/>
    <dbReference type="OMA" id="QLISVFW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="149"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB64014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="363" mass="40888" checksum="9BE6FC356595F2D4" modified="2005-12-06" version="1">MRFLRRPISLRQRLILTIGAILLVFELISVFWLWHESTEQIQLFEQALRDNRNNDRHIMREIREAVASLIVPGVFMVSLTLFICYQAVCRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTSTLDNERLFTADVAHELRTPLAGVRLHLELLAKTHHIDVAPLVARLDQMMESVSQLLQLARAGQSFSSGNYQHVKLLEDVILPSYDELSTMLDQRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDGGAVMAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQETSGTRAWVRLKKDQNVANQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Y5</accession>
    <name>Q329Y5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">dapF</name>
        <name evidence="10" type="ordered locus">SDY_3936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Y5"/>
    <dbReference type="STRING" id="300267.SDY_3936"/>
    <dbReference type="EnsemblBacteria" id="ABB63870">
        <property type="protein sequence ID" value="ABB63870"/>
        <property type="gene ID" value="SDY_3936"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3936"/>
    <dbReference type="HOGENOM" id="CLU_053306_1_1_6"/>
    <dbReference type="OMA" id="HVAMRVH"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="site" description="Important for dimerization" evidence="8">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="275" mass="30340" checksum="AE3C0D5516ABE525" modified="2005-12-06" version="1">MMQFSKMHGLGNDFMVVDAVTQNVFFSPELIRRLADRHLGVGFDQLLVVEPPYDPELDFHYRIFNADGSEVAQCGNGARCFARFVRLKGLTNKRDIRVSTANGRMVLTVTDDDLVRVNMGEPNFEPSAVPFRANKAEKTYIMRAAEQTILCGVVSMGNPHCVIQVDDVDTAAVETLGPVLESHERFPERANIGFMQVVKREHIRLRVYERGAGETQACGSGACAAVAVGIQQGLLAEEVRVELPGGRLDIAWKGPGHPLYMTGPAVHVYDGFIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A19</accession>
    <name>Q32A19_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferrisiderophore reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiB</name>
        <name evidence="2" type="ordered locus">SDY_3901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005017003.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405327.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A19"/>
    <dbReference type="STRING" id="300267.SDY_3901"/>
    <dbReference type="EnsemblBacteria" id="ABB63836">
        <property type="protein sequence ID" value="ABB63836"/>
        <property type="gene ID" value="SDY_3901"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3901"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4609"/>
    <dbReference type="HOGENOM" id="CLU_003827_7_4_6"/>
    <dbReference type="OMA" id="PCRHEGE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="233" mass="26257" checksum="6295ED387E973927" modified="2005-12-06" version="1">MTTLSCKVTSVEAITNTVYRVRIVPDAAFSFRAGQYLMVVMDERDKRPFSMASTPDEKGFIELHIGASEINLYAKAVMDRILKDHQIVVDIPHGEAWLRDDEERPMILIAGGTGFSYARSILLTALARNPNRDITIYWGGREEQHLYDLCELEALSLKHLGLQVVPVVEQPEAGWRGRTGTVLTAVLQDHGTLAEHDIYIAGRFEMAKIARDLFCSERNAREDRLFGDAFAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A25</accession>
    <name>Q32A25_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protoporphyrinogen IX dehydrogenase [quinone]</fullName>
            <ecNumber evidence="6">1.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protoporphyrinogen IX dehydrogenase [menaquinone]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protoporphyrinogen IX dehydrogenase [ubiquinone]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protoporphyrinogen oxidase</fullName>
            <shortName evidence="6">PPO</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">hemG</name>
        <name evidence="8" type="ordered locus">SDY_3895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:27409"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3 a quinone + protoporphyrinogen IX = 3 a quinol + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:65032"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:63936"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN non-covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HemG family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavodoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.3" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000853959.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405321.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A25"/>
    <dbReference type="SMR" id="Q32A25"/>
    <dbReference type="STRING" id="300267.SDY_3895"/>
    <dbReference type="EnsemblBacteria" id="ABB63830">
        <property type="protein sequence ID" value="ABB63830"/>
        <property type="gene ID" value="SDY_3895"/>
    </dbReference>
    <dbReference type="GeneID" id="58462188"/>
    <dbReference type="KEGG" id="sdy:SDY_3895"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4603"/>
    <dbReference type="HOGENOM" id="CLU_094839_0_1_6"/>
    <dbReference type="OMA" id="IEYTDWE"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070819">
        <property type="term" value="F:menaquinone-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00853">
        <property type="entry name" value="HemG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044264">
        <property type="entry name" value="HemG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="181" mass="21226" checksum="BCCB5AE594010026" modified="2005-12-06" version="1">MKTLILFSTRDGQTREIASYLASELKELGIQADVANVHRIEEPQWENYDRVVIGASIRYGHYHSAFQEFVKKHATRLNSMPSAFYSVNLVARKPEKRTPQTNSYARKFLMNSQWRPDRCAVIAGALRYPRYRWYDRFMIKLIMKMSGGETDTRKEVVYTDWEQVANFAREIAHLTDKPTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A42</accession>
    <name>Q32A42_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="4">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yihK</name>
        <name evidence="4" type="synonym">bipA</name>
        <name evidence="6" type="ordered locus">SDY_3872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000570668.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405304.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A42"/>
    <dbReference type="SMR" id="Q32A42"/>
    <dbReference type="STRING" id="300267.SDY_3872"/>
    <dbReference type="EnsemblBacteria" id="ABB63813">
        <property type="protein sequence ID" value="ABB63813"/>
        <property type="gene ID" value="SDY_3872"/>
    </dbReference>
    <dbReference type="GeneID" id="66672223"/>
    <dbReference type="KEGG" id="sdy:SDY_3872"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4578"/>
    <dbReference type="HOGENOM" id="CLU_017016_4_0_6"/>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="607" mass="67355" checksum="3B4DE3A514F95FFB" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AC7</accession>
    <name>Q32AC7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yijI</name>
        <name evidence="1" type="ordered locus">SDY_3783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AC7"/>
    <dbReference type="EnsemblBacteria" id="ABB63728">
        <property type="protein sequence ID" value="ABB63728"/>
        <property type="gene ID" value="SDY_3783"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3783"/>
    <dbReference type="HOGENOM" id="CLU_143535_0_0_6"/>
    <dbReference type="OMA" id="APEITSX"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="154" mass="16589" checksum="C7ABBEAA3CC7FD95" modified="2005-12-06" version="1">MRARIICGFRLVSETGSGSSSSDLTSASGASQWGNSSRSHWLKRWCASCSSAPEISNWQLSPASVSVPISARALLALLLRSVRRLCHSICDEKVLHSVSTWLAGRACTPLGSSQINSTIRAIASLPVRFSVYRIRAHGNGLPCDKSAKSWTNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AP1</accession>
    <name>Q32AP1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405105.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AP1"/>
    <dbReference type="EnsemblBacteria" id="ABB63614">
        <property type="protein sequence ID" value="ABB63614"/>
        <property type="gene ID" value="SDY_3646"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3646"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4328"/>
    <dbReference type="HOGENOM" id="CLU_102496_0_0_6"/>
    <dbReference type="OMA" id="NCTEDSC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="177" mass="20505" checksum="1603648140534E2F" modified="2005-12-06" version="1">MLRYNVTLNIGLTSRNVWPGFYLDTATISRLSACGADFGFDPYISDVPDVQCDLNTTNDFTVHFTAMLNPDERVIIAKRPLKKCDSLIEDVYIFQVFKEAWKFHSDNNLRGFRDKQAELKLYARHYTVENCTEDSCRDCNYCILPSFFLSRSAIIRLNAANARFVYQPFTRDQRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AR8</accession>
    <name>Q32AR8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Ribosomal RNA small subunit methyltransferase D</fullName>
            <ecNumber evidence="4 8">2.1.1.171</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yhhF</name>
        <name evidence="9" type="ordered locus">SDY_3616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>guanosine(966) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:23548"/>
            <dbReference type="Rhea" id="RHEA-COMP:10211"/>
            <dbReference type="Rhea" id="RHEA-COMP:10212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.171"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the methyltransferase superfamily. RsmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.171" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000743197.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405078.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AR8"/>
    <dbReference type="STRING" id="300267.SDY_3616"/>
    <dbReference type="EnsemblBacteria" id="ABB63587">
        <property type="protein sequence ID" value="ABB63587"/>
        <property type="gene ID" value="SDY_3616"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3616"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4292"/>
    <dbReference type="HOGENOM" id="CLU_075826_2_2_6"/>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052913">
        <property type="term" value="F:16S rRNA (guanine(966)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR004553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="198" mass="21708" checksum="04FB9D81B256E605" modified="2005-12-06" version="1">MKKPNHSGSGQIRIIGGQWRGRKLPVPDSPGLRPTTDRVRETLFNWLAPVIVDAQCLDCFAGSGALGLEALSRYAAGATLIEMDRAVSQQLIKNLATLKAGNARVVNSNAMSFLAQKGTPHNIVFVDPPFRRGLLEETINLLEDNGWLADEALIYVESEVENSLPTVPANWSLHREKVAGQVAYRLYQREAQGESDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AT6</accession>
    <name>Q32AT6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhhA</name>
        <name evidence="3" type="ordered locus">SDY_3596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000825994.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405060.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AT6"/>
    <dbReference type="STRING" id="300267.SDY_3596"/>
    <dbReference type="EnsemblBacteria" id="ABB63569">
        <property type="protein sequence ID" value="ABB63569"/>
        <property type="gene ID" value="SDY_3596"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3596"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4269"/>
    <dbReference type="HOGENOM" id="CLU_161250_0_0_6"/>
    <dbReference type="OMA" id="RMQTEMM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020158">
        <property type="entry name" value="DUF2756"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10956">
        <property type="entry name" value="DUF2756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220617" evidence="2">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="146" mass="16594" checksum="DF2AFF51801D3955" modified="2005-12-06" version="1">MKRLLILTALLPFVGFAQPINTLNNPNQPGYQIPSQQRMQTQMQTQQIQQKGMLNQQLKTQTQLQQQHLENQINNNSQRVLQSQPGERNPARQQMLPNTNGGMLNSNRNPDSSLNQQHMLPERRNGDMLNQPGTPQPDIPLKTIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C44</accession>
    <name>Q32C44_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">General secretion pathway protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">gspF</name>
        <name evidence="18" type="ordered locus">SDY_3095</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cell inner membrane</location>
            <topology evidence="3 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001173470.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404602.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C44"/>
    <dbReference type="STRING" id="300267.SDY_3095"/>
    <dbReference type="EnsemblBacteria" id="ABB63111">
        <property type="protein sequence ID" value="ABB63111"/>
        <property type="gene ID" value="SDY_3095"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3095"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3704"/>
    <dbReference type="HOGENOM" id="CLU_035032_0_1_6"/>
    <dbReference type="OMA" id="FEPLMIL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011850">
        <property type="entry name" value="T2SS_GspF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02120">
        <property type="entry name" value="GspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="17">
        <location>
            <begin position="72"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="17">
        <location>
            <begin position="275"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB63111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="399" mass="43948" checksum="545ACCFA5A09318E" modified="2005-12-06" version="1">MALFYYQALERNGRKTKGMIEADSERHARQLLRGKELIPVHIEARMNASSGGMLQRRRHAHRRVAAADLALFTCQLATLVQAAIPLETCLQAVSEQSEKLHVKSLGMALRSRIQEGYTLSDSLREHPRVFDSLFCSMVAAGEKSGHLDVVLNRLADYTEQRQRLKSRLLQAMLYPLVLLVVATSVVTILLAAVVPKIIEQFDHLGHALPATTRALIAMSDALQASGVYWLAGLLALLVLGQRLLKNPAMLLRWDKTLLRLPVTGRVARGLNTARFSRTLSILTASSVPLLEGIQTAAAVSANRYVEQQLLLAADRVREGSSLRAALAELRLFPPMMLYMIASGEQSGELETMLEQAAVNQEREFDTQVGLALGLFEPALVVMMAGVVLFIVIAILEPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C46</accession>
    <name>Q32C46_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative type II secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gspD</name>
        <name evidence="10" type="ordered locus">SDY_3093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial secretin family. GSP D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404600.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C46"/>
    <dbReference type="STRING" id="300267.SDY_3093"/>
    <dbReference type="EnsemblBacteria" id="ABB63109">
        <property type="protein sequence ID" value="ABB63109"/>
        <property type="gene ID" value="SDY_3093"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3093"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3702"/>
    <dbReference type="HOGENOM" id="CLU_006756_1_1_6"/>
    <dbReference type="OMA" id="QVKLFFG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013356">
        <property type="entry name" value="T2SS_GspD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02517">
        <property type="entry name" value="type_II_gspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Secretin_N" evidence="9">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="9">
        <location>
            <begin position="210"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="611" mass="65749" checksum="2CB79BF5EAD6AB5C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C53</accession>
    <name>Q32C53_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pitB</name>
        <name evidence="8" type="ordered locus">SDY_3086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000933302.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404593.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C53"/>
    <dbReference type="STRING" id="300267.SDY_3086"/>
    <dbReference type="EnsemblBacteria" id="ABB63102">
        <property type="protein sequence ID" value="ABB63102"/>
        <property type="gene ID" value="SDY_3086"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3086"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3693"/>
    <dbReference type="HOGENOM" id="CLU_015355_4_0_6"/>
    <dbReference type="OMA" id="RANPHKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="499" mass="53839" checksum="ED80DA7FA30B59E6" modified="2005-12-06" version="1">MLNLFVGLDIYTGLLLLLALAFVLFYEAINGFHDTANAVATVIYTRAMQPQLAVVMAAFFNFFGVLLGGLSVAYAIVHMLPTDLLLNMGSTHGLAMVFSMLLAAIIWNLGTWFFGLPASSSHTLIGAIIGIGLTNALLTGSSVMDALNLREVTKIFSSLIVSPIVGLVIAGGLIFLLRRYWSGTKKRDRIHRIPEDRKKKKGKRKPPFWTRIALIVSAAGVAFSHGANDGQKGIGLVMLVLVGIAPAGFVVNMNASGYEITRTRDAVTNFEHYLQQHPELPQKLITMEPPLPAASTDGAQVTEFHCHPANTFDAIARVKTMLPGNMESYEPLSVSQRSQLRRIMLCISDTSAKLAKLPGVSKEDQNLLKKLRSDMLSTIEYAPVWIIMAVALALGIGTMIGWRRVAMTIGEKIGKRGMTYAQGMAAQMTAAVSIGLASYIGMPVSTTHVLSSAVAGTMVVDGGGLQRKTVTSILMAWVFTLPAAIFLSGGLYWIALQLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C94</accession>
    <name>TYSY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidylate synthase</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
            <ecNumber evidence="1">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyA</name>
        <name type="ordered locus">SDY_3044</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000816253.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404552.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C94"/>
    <dbReference type="SMR" id="Q32C94"/>
    <dbReference type="STRING" id="300267.SDY_3044"/>
    <dbReference type="EnsemblBacteria" id="ABB63061">
        <property type="protein sequence ID" value="ABB63061"/>
        <property type="gene ID" value="SDY_3044"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3044"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3649"/>
    <dbReference type="HOGENOM" id="CLU_021669_0_0_6"/>
    <dbReference type="OMA" id="KQYLDLC"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000000679" description="Thymidylate synthase">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="166"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <sequence length="264" mass="30493" checksum="9D11610EE4C108D0" modified="2005-12-06" version="1">MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGNTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C97</accession>
    <name>Q32C97_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ygdB</name>
        <name evidence="1" type="ordered locus">SDY_3041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C97"/>
    <dbReference type="STRING" id="300267.SDY_3041"/>
    <dbReference type="EnsemblBacteria" id="ABB63058">
        <property type="protein sequence ID" value="ABB63058"/>
        <property type="gene ID" value="SDY_3041"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3041"/>
    <dbReference type="HOGENOM" id="CLU_140267_0_0_6"/>
    <dbReference type="OMA" id="GGWLDFC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019652">
        <property type="entry name" value="DUF2509"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10713">
        <property type="entry name" value="DUF2509"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="121" mass="13315" checksum="D9238B85EFCF9D80" modified="2005-12-06" version="1">MLLVLGSLLLQGMSQQDRSFASRVSMESQSLRRQAIVQSALAWGKMHSWQTQPAVQCSQYAGTDARVCLRLLADNEALLIAGYEGVSLWRTGEVIDGNIVFSPRGWSDFCPLKEGALCQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CA9</accession>
    <name>Q32CA9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_3027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404537.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CA9"/>
    <dbReference type="STRING" id="300267.SDY_3027"/>
    <dbReference type="EnsemblBacteria" id="ABB63046">
        <property type="protein sequence ID" value="ABB63046"/>
        <property type="gene ID" value="SDY_3027"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3027"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3633"/>
    <dbReference type="HOGENOM" id="CLU_182841_0_1_6"/>
    <dbReference type="OMA" id="GHHQQIN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010305">
        <property type="entry name" value="DUF903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37011">
        <property type="entry name" value="PTHR37011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06004">
        <property type="entry name" value="DUF903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220888" evidence="5">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="76" mass="8305" checksum="D2E67120ED47E1AE" modified="2005-12-06" version="1">MMKKTAAIISACMLTFALSACSGSNYVMHTNDGRTIVSDGKPQTDNDTGMISYKDANGNKQQINRTDVKEMVELDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CF1</accession>
    <name>Q32CF1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ygcF</name>
        <name evidence="5" type="synonym">queE</name>
        <name evidence="7" type="ordered locus">SDY_2981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001199973.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404495.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CF1"/>
    <dbReference type="SMR" id="Q32CF1"/>
    <dbReference type="STRING" id="300267.SDY_2981"/>
    <dbReference type="EnsemblBacteria" id="ABB63004">
        <property type="protein sequence ID" value="ABB63004"/>
        <property type="gene ID" value="SDY_2981"/>
    </dbReference>
    <dbReference type="GeneID" id="60903488"/>
    <dbReference type="KEGG" id="sdy:SDY_2981"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3577"/>
    <dbReference type="HOGENOM" id="CLU_066739_3_0_6"/>
    <dbReference type="OMA" id="CDVKESW"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027609">
        <property type="entry name" value="rSAM_QueE_Proteobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04322">
        <property type="entry name" value="rSAM_QueE_Ecoli"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="18"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="223" mass="25030" checksum="A717AAF18F2A5D70" modified="2005-12-06" version="1">MQYPINEMFQTLQGEGYFTGVPAIFIRLQGCPVGCAWCDTKHTWEKLEDREVSLFSILAKTKESDKWGAASSEDLLAVIGRQGYTARHVVITGGEPCIHDLLPLTDLLEKNGFSCQIETSGTHEVRCTPNTWVTVSPKLNMRGGYEVLSQALERANEIKHPVGRVRDIEALDELLATLTDDKPRVIALQPISQKDDATRLCIETCIARNWRLSMQTHKYLNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CG2</accession>
    <name>Q32CG2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="8">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ygcM</name>
        <name evidence="11" type="ordered locus">SDY_2967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404484.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CG2"/>
    <dbReference type="STRING" id="300267.SDY_2967"/>
    <dbReference type="EnsemblBacteria" id="ABB62993">
        <property type="protein sequence ID" value="ABB62993"/>
        <property type="gene ID" value="SDY_2967"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2967"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3559"/>
    <dbReference type="HOGENOM" id="CLU_111016_6_1_6"/>
    <dbReference type="OMA" id="KCEKLHG"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00039">
        <property type="entry name" value="6PTHBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03367">
        <property type="entry name" value="queuosine_QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="121" mass="13787" checksum="71F4F2A2E72CE961" modified="2005-12-06" version="1">MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPIVPLLSAVMVKETCTAGCIYRGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CX4</accession>
    <name>NADK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD kinase</fullName>
            <ecNumber evidence="1">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadK</name>
        <name type="ordered locus">SDY_2788</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001059174.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404322.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CX4"/>
    <dbReference type="SMR" id="Q32CX4"/>
    <dbReference type="STRING" id="300267.SDY_2788"/>
    <dbReference type="EnsemblBacteria" id="ABB62831">
        <property type="protein sequence ID" value="ABB62831"/>
        <property type="gene ID" value="SDY_2788"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2788"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3360"/>
    <dbReference type="HOGENOM" id="CLU_008831_0_1_6"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000229688" description="NAD kinase">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="188"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <sequence length="292" mass="32520" checksum="C560E5105C42E2FA" modified="2005-12-06" version="1">MNNHFKCIGIVGHPRHPTALTTHEMLYRWLCTKGYEVIVEQQIAHELQLKNVKTGTLAEIGQLADLAVVVGGDGNMLGAARTLARYDIKVIGINRGNLGFLTDLDPDNAQQQLADVLEGHYTSEKRFLLEAQVCQQDCQKRISTAINEVVLHPGKVAHMIEFEVYIDEIFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPSLDAITLVPMFPHTLSARPLVINSSSTIRLRFSHRRNDLEISCDSQIALPIQEGEDVLIRRCDYHLNLIHPKDYSYLNTLSTKLGWSKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D04</accession>
    <name>Q32D04_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tail fiber protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D04"/>
    <dbReference type="EnsemblBacteria" id="ABB62801">
        <property type="protein sequence ID" value="ABB62801"/>
        <property type="gene ID" value="SDY_2758"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2758"/>
    <dbReference type="HOGENOM" id="CLU_876874_0_0_6"/>
    <dbReference type="OMA" id="GISAPCT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="291" mass="31667" checksum="4E6A7167B413972C" modified="2005-12-06" version="1">MAVAAGYARVAEQAKNDIDAALTGTLKTANHLSEIAAAGEKAQQKSRDSLGLKSAATMEAQSDIYDRTKGRLAIPGAFGFGRAFLYEDVIRFDAKDDFLVWVRNALPGEYSVAAPYGIIIPDTLFEGVLSIRWTDARPETREPRRRAKSFTFYGINGPIYHACCRLLSGFLTDWVKINITAEDIIYRIAASSVRNRWGDPDIGGLIIAAYQGEADGDKVIRLVRGQSYRGSRLGPVGISAPCTPTGTHIVYPQYFITGCSEHSLPGSYRVLSGVPDTYVSGAMLGLFIRTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DD5</accession>
    <name>PDXK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxine/pyridoxal/pyridoxamine kinase</fullName>
            <shortName evidence="1">PN/PL/PM kinase</shortName>
            <ecNumber evidence="1">2.7.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">B6-vitamer kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxK</name>
        <name type="ordered locus">SDY_2615</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17310"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:25108"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16709"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:25104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57761"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family. PdxK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000096652.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404161.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DD5"/>
    <dbReference type="SMR" id="Q32DD5"/>
    <dbReference type="STRING" id="300267.SDY_2615"/>
    <dbReference type="EnsemblBacteria" id="ABB62670">
        <property type="protein sequence ID" value="ABB62670"/>
        <property type="gene ID" value="SDY_2615"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2615"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3152"/>
    <dbReference type="HOGENOM" id="CLU_046496_3_1_6"/>
    <dbReference type="OMA" id="ITYICDP"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00298"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00299"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01638">
        <property type="entry name" value="PdxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023479">
        <property type="entry name" value="PdxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PTHR10534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000268842" description="Pyridoxine/pyridoxal/pyridoxamine kinase">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="221"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01638"/>
        </source>
    </evidence>
    <sequence length="283" mass="30832" checksum="902F9ECC6EA519C0" modified="2005-12-06" version="1">MSSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHYDTFYGGAIPDEWFSGYLRALQERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDLLIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNIFELEILTGKNCRDLDSAIAAAKSLLSDTLKWVVITSASGNEENQEMQVAVVSADSVNVISHSRVKTDLKGTGDLFCAQLISGLLKGKALNDAVHRAGLRVLEVMRYTQQHESDELILPPLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DJ0</accession>
    <name>Q32DJ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DJ0"/>
    <dbReference type="EnsemblBacteria" id="ABB62615">
        <property type="protein sequence ID" value="ABB62615"/>
        <property type="gene ID" value="SDY_2546"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2546"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="79" mass="8842" checksum="F18292889D790D75" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITNSLRRTSRTSENMPFPSCLSVDTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DJ5</accession>
    <name>Q32DJ5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001195815.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404101.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DJ5"/>
    <dbReference type="STRING" id="300267.SDY_2541"/>
    <dbReference type="EnsemblBacteria" id="ABB62610">
        <property type="protein sequence ID" value="ABB62610"/>
        <property type="gene ID" value="SDY_2541"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2541"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3058"/>
    <dbReference type="HOGENOM" id="CLU_084603_1_1_6"/>
    <dbReference type="OMA" id="MQVLIMR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004449">
        <property type="entry name" value="SixA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00249">
        <property type="entry name" value="sixA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="161" mass="17238" checksum="98CBE24DAC1FEDA7" modified="2005-12-06" version="1">MQVFIMRHGDAALDAASDSVRPLTTNGCDESRLMANWLKGQKVEIERVLVSPFLRAEQTLEEVGDCLNLPSSAEVLPELMPCGDVGLVSAYLQALTNEGVASVLVISHLPLVGYLVAELCPGETPPMFTTSAIASVTLDESGNGTFNWQMSPCNLKMAKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DK3</accession>
    <name>Q32DK3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fimbrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000738798.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404093.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DK3"/>
    <dbReference type="STRING" id="300267.SDY_2533"/>
    <dbReference type="EnsemblBacteria" id="ABB62602">
        <property type="protein sequence ID" value="ABB62602"/>
        <property type="gene ID" value="SDY_2533"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2533"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3049"/>
    <dbReference type="HOGENOM" id="CLU_114111_2_0_6"/>
    <dbReference type="OMA" id="LINPPPC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000259">
        <property type="entry name" value="Adhesion_dom_fimbrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00419">
        <property type="entry name" value="Fimbrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220668" description="Fimbrial domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Fimbrial" evidence="2">
        <location>
            <begin position="23"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="162" mass="17596" checksum="D70BF27145EE9D4F" modified="2005-12-06" version="1">MKKMSLILLCVANSVALAADEDITFHGTLVSPPSCTVSGGKTIEVDFSDLIIDSINGDYGRKEVDYELSCDSDTRDPGWDMTLTWTGNETSYNDAAIETDVPGFGIELLQNGQRFKLNTPLSINATDFTQKPKLEAVPVKASDAVLNDGSFSAYATLRVDYQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DT3</accession>
    <name>ARNA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional polymyxin resistance protein ArnA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">UDP-4-amino-4-deoxy-L-arabinose formyltransferase</fullName>
                <ecNumber evidence="1">2.1.2.13</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">ArnAFT</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">UDP-L-Ara4N formyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating</fullName>
                <ecNumber evidence="1">1.1.1.305</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">ArnADH</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">UDP-GlcUA decarboxylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">UDP-glucuronic acid dehydrogenase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">arnA</name>
        <name type="ordered locus">SDY_2451</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + UDP-alpha-D-glucuronate = CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose</text>
            <dbReference type="Rhea" id="RHEA:24702"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58710"/>
            <dbReference type="EC" id="1.1.1.305"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose = (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose</text>
            <dbReference type="Rhea" id="RHEA:24706"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58708"/>
            <dbReference type="ChEBI" id="CHEBI:58709"/>
            <dbReference type="EC" id="2.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer, formed by a dimer of trimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the Fmt family. UDP-L-Ara4N formyltransferase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous termination">
            <sequence resource="EMBL-CDS" id="ABB62522" version="1"/>
        </conflict>
        <text>Truncated C-terminus.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.13" evidence="1"/>
    <dbReference type="EC" id="1.1.1.305" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62522.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DT3"/>
    <dbReference type="SMR" id="Q32DT3"/>
    <dbReference type="STRING" id="300267.SDY_2451"/>
    <dbReference type="EnsemblBacteria" id="ABB62522">
        <property type="protein sequence ID" value="ABB62522"/>
        <property type="gene ID" value="SDY_2451"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2451"/>
    <dbReference type="HOGENOM" id="CLU_007383_23_1_6"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00032">
        <property type="reaction ID" value="UER00492"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00032">
        <property type="reaction ID" value="UER00494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099619">
        <property type="term" value="F:UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099618">
        <property type="term" value="F:UDP-glucuronic acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05257">
        <property type="entry name" value="Arna_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01166">
        <property type="entry name" value="ArnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045869">
        <property type="entry name" value="Arna-like_SDR_e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021168">
        <property type="entry name" value="Bifun_polymyxin_resist_ArnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036506">
        <property type="entry name" value="Bifun_polymyxin_resist_ArnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000281728" description="Bifunctional polymyxin resistance protein ArnA">
        <location>
            <begin position="1"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Formyltransferase ArnAFT">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dehydrogenase ArnADH">
        <location>
            <begin position="314"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for formyltransferase activity" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for decarboxylase activity" evidence="1">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for decarboxylase activity" evidence="1">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="368"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="432"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="660" mass="74193" checksum="8EDDF43857D4C0B2" modified="2007-03-20" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DT4</accession>
    <name>ARNC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase</fullName>
            <ecNumber evidence="1">2.4.2.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl-phosphate Ara4FN transferase</fullName>
            <shortName evidence="1">Ara4FN transferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">arnC</name>
        <name type="ordered locus">SDY_2450</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose = 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:27722"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58709"/>
            <dbReference type="ChEBI" id="CHEBI:58909"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="2.4.2.53"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="ABB62521" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.4.2.53" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62521.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DT4"/>
    <dbReference type="SMR" id="Q32DT4"/>
    <dbReference type="STRING" id="300267.SDY_2450"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62521">
        <property type="protein sequence ID" value="ABB62521"/>
        <property type="gene ID" value="SDY_2450"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2450"/>
    <dbReference type="HOGENOM" id="CLU_033536_0_0_6"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00036">
        <property type="reaction ID" value="UER00495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099621">
        <property type="term" value="F:undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036108">
        <property type="term" value="P:4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01164">
        <property type="entry name" value="ArnC_transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022857">
        <property type="entry name" value="ArnC_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000380273" description="Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="322" mass="36355" checksum="BE363C2C8AFAFD14" modified="2009-07-28" version="2">MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREYGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-11-04" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DU2</accession>
    <name>RHMA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-keto-3-deoxy-L-rhamnonate aldolase</fullName>
            <shortName evidence="1">KDR aldolase</shortName>
            <ecNumber evidence="1">4.1.2.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-dehydro-3-deoxyrhamnonate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhmA</name>
        <name type="ordered locus">SDY_2440</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:25784"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:58371"/>
            <dbReference type="EC" id="4.1.2.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.53" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000992971.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404004.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DU2"/>
    <dbReference type="SMR" id="Q32DU2"/>
    <dbReference type="STRING" id="300267.SDY_2440"/>
    <dbReference type="EnsemblBacteria" id="ABB62513">
        <property type="protein sequence ID" value="ABB62513"/>
        <property type="gene ID" value="SDY_2440"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2440"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2940"/>
    <dbReference type="HOGENOM" id="CLU_059964_1_0_6"/>
    <dbReference type="OMA" id="SATWAKK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106099">
        <property type="term" value="F:2-keto-3-deoxy-L-rhamnonate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01290">
        <property type="entry name" value="KDR_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023593">
        <property type="entry name" value="KDR_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000353179" description="2-keto-3-deoxy-L-rhamnonate aldolase">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="site" description="Increases basicity of active site His" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01290"/>
        </source>
    </evidence>
    <sequence length="267" mass="28921" checksum="270B606E2EB8FF3F" modified="2005-12-06" version="1">MNALLTNPFKERLCKGEVQIGLWLSSTTAYMAEIAATSGYDWLLIDGEHAPNTIQDLYHQLQAVAPYASQPVIRPVEGSKPLIKQVLDIGAQTLLLPMVDTADQARQVVSATRYPPYGERGVGASVARAARWGRIENYMAQVNDSLCLLVQVESKTALDNLDKILDVQGIDGVFIGPADLSASLGYPDNAGHLEVQRIIETSIRRIRDAGKAAGFLAVAPDMAQQCLAWGANFVAVGVDTMLYSDALDQRLAMFKSGKNGPRIKGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DZ4</accession>
    <name>Q32DZ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_2387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403952.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DZ4"/>
    <dbReference type="STRING" id="300267.SDY_2387"/>
    <dbReference type="EnsemblBacteria" id="ABB62461">
        <property type="protein sequence ID" value="ABB62461"/>
        <property type="gene ID" value="SDY_2387"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2387"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2880"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="OMA" id="ARIMGVW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="9958" checksum="FCCC4CD823AD5AD4" modified="2005-12-06" version="1">MAFVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVSLNTILRHLKNSGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E21</accession>
    <name>Q32E21_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable formate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">focA</name>
        <name evidence="7" type="ordered locus">SDY_2357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FNT transporter (TC 2.A.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000642546.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403925.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E21"/>
    <dbReference type="SMR" id="Q32E21"/>
    <dbReference type="STRING" id="300267.SDY_2357"/>
    <dbReference type="EnsemblBacteria" id="ABB62434">
        <property type="protein sequence ID" value="ABB62434"/>
        <property type="gene ID" value="SDY_2357"/>
    </dbReference>
    <dbReference type="GeneID" id="67414208"/>
    <dbReference type="KEGG" id="sdy:SDY_2357"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2844"/>
    <dbReference type="HOGENOM" id="CLU_036896_3_0_6"/>
    <dbReference type="OMA" id="MIWFPIM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015499">
        <property type="term" value="F:formate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023999">
        <property type="entry name" value="Formate_transptr_FocA_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00790">
        <property type="entry name" value="fnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04060">
        <property type="entry name" value="formate_focA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01005">
        <property type="entry name" value="FORMATE_NITRITE_TP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="285" mass="30991" checksum="E0B06FFFC362DE16" modified="2005-12-06" version="1">MKADNPFDLLLPAAMAKVAEEAGVYKATKHPLKTFYLAITAGVFISIAFVFYITATTGTGTMPFGMAKLVGGICFSLGLILCVVCGADLFTSTVLIVVAKASGRITWGQLAKNWLNVYFGNLVGALLFVLLMWLSGEYMTANGQWGLNVLQTADHKVHHTFIEAVCLGILANLMVCLAVWMSYSGRSLMDKAFIMVLPVAMFVASGFEHSIANMFMIPMGIVIRDFASPEFWTAVGSAPENFSHLTVMNFITDNLIPVTIGNIIGGGLLVGLTYWVIYLRENDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E40</accession>
    <name>Q32E40_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycbC</name>
        <name evidence="3" type="ordered locus">SDY_2338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000899608.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403906.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E40"/>
    <dbReference type="STRING" id="300267.SDY_2338"/>
    <dbReference type="EnsemblBacteria" id="ABB62415">
        <property type="protein sequence ID" value="ABB62415"/>
        <property type="gene ID" value="SDY_2338"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2338"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2822"/>
    <dbReference type="HOGENOM" id="CLU_053514_0_0_6"/>
    <dbReference type="OMA" id="LWFTRWQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="80"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="259" mass="28692" checksum="7CEF38CA48095EC7" modified="2005-12-06" version="1">MLFTLKKVIGNMLLPLPLMLLIIGAGLALLWFSRFQKTGKIFISIGWLSLLLLSLQPVADRLLRPIESTYPTWNNSQKVDYIVVLGGGYTWNPQWAPSSNLINNSLPRLNEGIRLWRENPGSKLIFTGGVAKTNTVSTAEVGARVAQSLGVPREQIITLDLPKDTEEEAAAVKQAIGDAPFLLVTSASHLPRAMIFFQQEGLNPLPAPANQLAIDSPLNPWERAIPSPVWLMHSDRVGYETLGRIWQWLKGPSGEPRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E41</accession>
    <name>Q32E41_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA 5-carboxymethoxyuridine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">cmo5U methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">smtA</name>
        <name evidence="1" type="synonym">cmoM</name>
        <name evidence="2" type="ordered locus">SDY_2337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54080"/>
            <dbReference type="Rhea" id="RHEA-COMP:13383"/>
            <dbReference type="Rhea" id="RHEA-COMP:13781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:136879"/>
            <dbReference type="ChEBI" id="CHEBI:138053"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001298300.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403905.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E41"/>
    <dbReference type="SMR" id="Q32E41"/>
    <dbReference type="STRING" id="300267.SDY_2337"/>
    <dbReference type="EnsemblBacteria" id="ABB62414">
        <property type="protein sequence ID" value="ABB62414"/>
        <property type="gene ID" value="SDY_2337"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2337"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2821"/>
    <dbReference type="HOGENOM" id="CLU_061533_0_1_6"/>
    <dbReference type="OMA" id="CHGVLEY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097697">
        <property type="term" value="F:tRNA 5-carboxymethoxyuridine methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02057">
        <property type="entry name" value="tRNA_methyltr_CmoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033664">
        <property type="entry name" value="Cmo5U_methylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="52"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="261" mass="29814" checksum="EB8B4CB681A2DC1C" modified="2005-12-06" version="1">MQDRNFDDIAEKFSRNIYGTTKGQLRQAILWQDLDRVLAEMGPQKLRVLDAGGGEGQTAIKMAERGHQVILCDLSAQMIDRAKQAAEAKGVSDNMQFIHCAAQDVASHLETPVDLILFHAVLEWVADPRSVLQTLWSVLRPGGVLSLMFYNAHGLLMHNMVAGNFDYVQAGMPKKKKRTLSPDYPRDPAQVYLWLEEAGWQIMGKTGVRVFHDYLREKHQQRDCYEALLELETRYCRQEPYITLGRYIHVTARKPQSKDKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E44</accession>
    <name>MUKB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromosome partition protein MukB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Structural maintenance of chromosome-related protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mukB</name>
        <name type="ordered locus">SDY_2334</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
        <text evidence="1">Restricted to the nucleoid region.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. MukB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000572767.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403902.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E44"/>
    <dbReference type="SMR" id="Q32E44"/>
    <dbReference type="STRING" id="300267.SDY_2334"/>
    <dbReference type="EnsemblBacteria" id="ABB62411">
        <property type="protein sequence ID" value="ABB62411"/>
        <property type="gene ID" value="SDY_2334"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2334"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2818"/>
    <dbReference type="HOGENOM" id="CLU_004430_0_0_6"/>
    <dbReference type="OMA" id="FIAVYQH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01800">
        <property type="entry name" value="MukB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012090">
        <property type="entry name" value="MukB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032520">
        <property type="entry name" value="MukB_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042501">
        <property type="entry name" value="MukB_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007406">
        <property type="entry name" value="MukB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04310">
        <property type="entry name" value="MukB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16330">
        <property type="entry name" value="MukB_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005246">
        <property type="entry name" value="MukB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0226">DNA condensation</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000069913" description="Chromosome partition protein MukB">
        <location>
            <begin position="1"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible hinge" evidence="1">
        <location>
            <begin position="666"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="444"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="509"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="780"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="837"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01800"/>
        </source>
    </evidence>
    <sequence length="1483" mass="169899" checksum="43BDADD0E653F422" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E46</accession>
    <name>Q32E46_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ycbB</name>
        <name evidence="9" type="ordered locus">SDY_2332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000925983.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403900.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E46"/>
    <dbReference type="STRING" id="300267.SDY_2332"/>
    <dbReference type="EnsemblBacteria" id="ABB62409">
        <property type="protein sequence ID" value="ABB62409"/>
        <property type="gene ID" value="SDY_2332"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2332"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2815"/>
    <dbReference type="HOGENOM" id="CLU_020360_3_0_6"/>
    <dbReference type="OMA" id="HNLFQRD"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045380">
        <property type="entry name" value="LD_TPept_scaffold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20142">
        <property type="entry name" value="Scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220934" evidence="5">
        <location>
            <begin position="31"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Scaffold" evidence="8">
        <location>
            <begin position="93"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="6">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="7">
        <location>
            <begin position="377"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="615" mass="67862" checksum="4CD0A07A0994F0EE" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E79</accession>
    <name>Q32E79_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acidic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">msyB</name>
        <name evidence="2" type="ordered locus">SDY_2299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403867.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E79"/>
    <dbReference type="STRING" id="300267.SDY_2299"/>
    <dbReference type="EnsemblBacteria" id="ABB62376">
        <property type="protein sequence ID" value="ABB62376"/>
        <property type="gene ID" value="SDY_2299"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2299"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2775"/>
    <dbReference type="HOGENOM" id="CLU_162701_0_0_6"/>
    <dbReference type="OMA" id="NTLHEWE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025729">
        <property type="entry name" value="MsyB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13984">
        <property type="entry name" value="MsyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14390" checksum="DC235AC383306BEC" modified="2005-12-06" version="1">MMTMYATLEEAIDAAREEFLADNPGIDAEDANVQQFNAQKYVLQDGDIMWQVEFFADEGEEGECLPMLSGEAAQSVFDGDYDEIEIRQEWQEENTLHEWDEGEFQLEPPLDTEEGRAAADEWDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EU6</accession>
    <name>Q32EU6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EU6"/>
    <dbReference type="EnsemblBacteria" id="ABB62159">
        <property type="protein sequence ID" value="ABB62159"/>
        <property type="gene ID" value="SDY_2064"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2064"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7360" checksum="A1E58A8311FDBF60" modified="2005-12-06" version="1">MAVTAAKSVMAFRVMTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITQKWSLLTSISVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EW3</accession>
    <name>Q32EW3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycfF</name>
        <name evidence="3" type="ordered locus">SDY_2047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000807125.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403633.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EW3"/>
    <dbReference type="SMR" id="Q32EW3"/>
    <dbReference type="STRING" id="300267.SDY_2047"/>
    <dbReference type="EnsemblBacteria" id="ABB62142">
        <property type="protein sequence ID" value="ABB62142"/>
        <property type="gene ID" value="SDY_2047"/>
    </dbReference>
    <dbReference type="GeneID" id="67414296"/>
    <dbReference type="KEGG" id="sdy:SDY_2047"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2461"/>
    <dbReference type="HOGENOM" id="CLU_056776_8_1_6"/>
    <dbReference type="OMA" id="SDCLFCK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13241" checksum="F0E6AAF177DC820B" modified="2005-12-06" version="1">MAEETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIHMHLLGGRPLGPMLAHKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F27</accession>
    <name>Q32F27_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxy-terminal protease for penicillin-binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">prc</name>
        <name evidence="7" type="ordered locus">SDY_1978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001055786.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403569.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F27"/>
    <dbReference type="STRING" id="300267.SDY_1978"/>
    <dbReference type="MEROPS" id="S41.001"/>
    <dbReference type="EnsemblBacteria" id="ABB62078">
        <property type="protein sequence ID" value="ABB62078"/>
        <property type="gene ID" value="SDY_1978"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1978"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2388"/>
    <dbReference type="HOGENOM" id="CLU_016199_1_0_6"/>
    <dbReference type="OMA" id="HHYSKPP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020992">
        <property type="entry name" value="Tail_Prtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040573">
        <property type="entry name" value="TSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11818">
        <property type="entry name" value="DUF3340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17804">
        <property type="entry name" value="TSP_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220950" evidence="5">
        <location>
            <begin position="23"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="238"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="682" mass="76693" checksum="61B356FB559E6D78" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F29</accession>
    <name>Q32F29_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_1976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403567.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F29"/>
    <dbReference type="STRING" id="300267.SDY_1976"/>
    <dbReference type="EnsemblBacteria" id="ABB62076">
        <property type="protein sequence ID" value="ABB62076"/>
        <property type="gene ID" value="SDY_1976"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1976"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2385"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_6"/>
    <dbReference type="OMA" id="LDIIWRM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="54"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="460" mass="48885" checksum="3E5F1974B9EA2625" modified="2005-12-06" version="1">MVAIHLLPVSYNSATSTVNISARIIPLLIIHQRFKIPMPKVQADGLPLPQRYGAILTIVIGISMAVLDGAIANVALPTIATDLHATPASSIWVVNAYQIAIVISLLSFSFLGDMFGYRRIYKCGLVVFLLSSLFFALSDSLQMLTLARVIQGFGGAALMSVNTALIRLIYPQRFLGRGMGINSFIVAVSSAAGPTIAAAILSIASWKWLFLINVPLGIIALLLAIRFLPPNGSRASKPRFDLPRAVMNALTFGLLITALSGFAQGQSLTLIAAELVVMVVVGIFFIRRQLSLTVPLLPVDLLRIPLFSLSICTSVCSFCAQMLAMVSLPFYLQTVLGRSEVETGLLLTPWPLATMVMAPLAGYLIERVHAGLLGALGLFIMAAGLFSLVLLPASPADINIIWPMILCGAGFGLFQSPNNHTIITSAPRERSGGASGMLGTARLLGQSSGAGGADAKSVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F56</accession>
    <name>Q32F56_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F56"/>
    <dbReference type="STRING" id="300267.SDY_1947"/>
    <dbReference type="EnsemblBacteria" id="ABB62049">
        <property type="protein sequence ID" value="ABB62049"/>
        <property type="gene ID" value="SDY_1947"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1947"/>
    <dbReference type="HOGENOM" id="CLU_017290_0_0_6"/>
    <dbReference type="OMA" id="NPGQHEI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="84"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="423" mass="47438" checksum="5185120C6FF5F16D" modified="2005-12-06" version="1">MLPWKTYSCFKPEEARERVLFPGPVFAMDILGNVVEEAGLGQEMGEPDRTCVPVLGSLTPSAADPEFIGQMLLTMVDEDGAPFDVEPRNVLNRLWQQLRQRGLFPVVAVELEFYLLDRQRDAEGYLQPPCAPGTDDRNTQSQVYSVDNLNHFADVLNDIDELAQLQLIPADGVVAEASPGQFEINLYHTDNVLEACDDALALKRLVRLMAEKHKMHATFMAKPYEEHAGSGMHIHISMQNNRGENVLSDAEGEDSPLLKKMLAGMIDLMPSSMALLAPNVNSYRRFQPGMYVPTQASWGHNNRTVALRIPCGDRHNHLVEYRVAGADANPYLVMAAIFAGILHGLDNELPLQEEVEGNGLEQEGLPFPIRQSDALGEFIENDHLRRYLGERFCHVYHACKNDELLQFERLITETEIESMLKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FG6</accession>
    <name>Q32FG6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fumA</name>
        <name evidence="13" type="ordered locus">SDY_1828</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000066631.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403430.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FG6"/>
    <dbReference type="STRING" id="300267.SDY_1828"/>
    <dbReference type="EnsemblBacteria" id="ABB61939">
        <property type="protein sequence ID" value="ABB61939"/>
        <property type="gene ID" value="SDY_1828"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1828"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2201"/>
    <dbReference type="HOGENOM" id="CLU_026758_0_0_6"/>
    <dbReference type="OMA" id="AGVLPMC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="11">
        <location>
            <begin position="51"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="12">
        <location>
            <begin position="332"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB61939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="548" mass="60269" checksum="4DE5A39CE4A87FAD" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FH4</accession>
    <name>Q32FH4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yniC</name>
        <name evidence="2" type="ordered locus">SDY_1820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000106813.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403422.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FH4"/>
    <dbReference type="STRING" id="300267.SDY_1820"/>
    <dbReference type="EnsemblBacteria" id="ABB61931">
        <property type="protein sequence ID" value="ABB61931"/>
        <property type="gene ID" value="SDY_1820"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1820"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2193"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_1_6"/>
    <dbReference type="OMA" id="LWDNDGL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="222" mass="24274" checksum="3D6F551F227BE3B5" modified="2005-12-06" version="1">MSTPRQILAAIFDMDGLLIDSEPLWDRAELDVMASLGVDISRRNELPDTLGLRIDMVVDLWYAQQPWNGPSRQEVVERVIARAISLVEETRPLLPGVREAVALCKEQGLLVGLASASPLHMLEKVLTMFNLRDSFDALASAEKLPYSKPHPQVYLDCAAKLGVAPLTCVVLEDSVNGMIASKAARMRSIVVPAPEAQNDSRFVLANVKLSSLTELTAKDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FN1</accession>
    <name>Q32FN1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1338 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000013787.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403365.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FN1"/>
    <dbReference type="STRING" id="300267.SDY_1757"/>
    <dbReference type="EnsemblBacteria" id="ABB61874">
        <property type="protein sequence ID" value="ABB61874"/>
        <property type="gene ID" value="SDY_1757"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1757"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2116"/>
    <dbReference type="HOGENOM" id="CLU_026640_0_0_6"/>
    <dbReference type="OMA" id="RAMSDMY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16348">
        <property type="entry name" value="VOC_YdcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="DUF1338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1338" evidence="1">
        <location>
            <begin position="11"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="447" mass="51013" checksum="D7A09EE4CCC87C5B" modified="2005-12-06" version="1">MANSITADEIREQFSQAMSAMYQQEVPQYGTLLELVADVNLAVLENNPQLHEKMVNADELARLNVERHGAIRVGTAQELATLRRMFAIMGMYPVSYYDLSQAGVPVHSTAFRPIDDASLARNPFRVFTSLLRLELIENEILRQKAAEILRQRDIFTPRCRQLLEEYEQQGGFNETQAQEFVQEALETFRWHQSATVDEETYRALHNEHRLIADVVCFPGCHINHLTPRTLDIDRVQSMMPECGIEPKILIEGPPRREVPILLRQTSFKALEETVLFAGQKQGTHTARFGEIEQRGVALTPKGRQLYDDLLRNAGTGQDNLTHQMHLQETFRTFPDSEFLMRQQGLAWFRYRLTPSGEAHRQAIHPGDDPQPLIERGWVAVQPITYEDFLPVSAAGIFQSNLGNETQARSHGNASREAFEQALGCPVLDEFQLYQEAEERSKRRCGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FP6</accession>
    <name>Q32FP6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydcN</name>
        <name evidence="2" type="ordered locus">SDY_1742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000429144.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403350.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FP6"/>
    <dbReference type="STRING" id="300267.SDY_1742"/>
    <dbReference type="EnsemblBacteria" id="ABB61859">
        <property type="protein sequence ID" value="ABB61859"/>
        <property type="gene ID" value="SDY_1742"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1742"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2099"/>
    <dbReference type="HOGENOM" id="CLU_085376_5_0_6"/>
    <dbReference type="OMA" id="GMLIQIE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="178" mass="19725" checksum="755E8A494CDE028B" modified="2005-12-06" version="1">MENLARFLSTTLKQLRQQRGWSLSRLAEATGVSKAMLGQIERNESSPTVATLWKIATGLNVPFSTFISPPQSATPSVYDPQQQAMVIISLFPYDPQLCFEHFSIQMAPGAISESTPHEKGVIEHVVVIDGQLDLCVDGEWQSLNCGEGVRFAADVTHVYRNGGEQTVHFHSLIHYPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FV2</accession>
    <name>Q32FV2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_1682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403294.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FV2"/>
    <dbReference type="STRING" id="300267.SDY_1682"/>
    <dbReference type="EnsemblBacteria" id="ABB61803">
        <property type="protein sequence ID" value="ABB61803"/>
        <property type="gene ID" value="SDY_1682"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1682"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2028"/>
    <dbReference type="HOGENOM" id="CLU_045105_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="126" mass="13567" checksum="B5E0B4575CBD4647" modified="2005-12-06" version="1">MMSLNMASLETLWQTNAAGVSIVISSLGIGRLSVLLFAGLLSDRFGRRPFIMLGMCFYMAFFLGILQTNNIIIAYVFGFLAGMANSFLDAGTYPSLMEAFPRSPGTSNILIKAFVSSGQFLGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G12</accession>
    <name>Q32G12_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403234.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G12"/>
    <dbReference type="STRING" id="300267.SDY_1618"/>
    <dbReference type="EnsemblBacteria" id="ABB61743">
        <property type="protein sequence ID" value="ABB61743"/>
        <property type="gene ID" value="SDY_1618"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1618"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1946"/>
    <dbReference type="HOGENOM" id="CLU_1814511_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="142" mass="15221" checksum="4AA23E24CFC6BD0C" modified="2005-12-06" version="1">MMRVQLLSSDKMFGFTHATGTEFAGVAQFKDSTFTLERDNTAALTHAMLQSDSENTTSVKVGEQSIGGLAMNGGTLIFDTDIPAATLAEGYISVDTLVVGVSDYTWKGRNYQVNGTGDVLIDVLGDKGYSDTQGMLGVKYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G45</accession>
    <name>Q32G45_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403201.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G45"/>
    <dbReference type="STRING" id="300267.SDY_1580"/>
    <dbReference type="EnsemblBacteria" id="ABB61710">
        <property type="protein sequence ID" value="ABB61710"/>
        <property type="gene ID" value="SDY_1580"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1580"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1897"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15463" checksum="430424F096513276" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIRMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G54</accession>
    <name>Q32G54_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DMSO reductase anchor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000526470.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403192.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G54"/>
    <dbReference type="STRING" id="300267.SDY_1566"/>
    <dbReference type="EnsemblBacteria" id="ABB61701">
        <property type="protein sequence ID" value="ABB61701"/>
        <property type="gene ID" value="SDY_1566"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1566"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1878"/>
    <dbReference type="HOGENOM" id="CLU_064909_2_0_6"/>
    <dbReference type="OMA" id="MMSNEIA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019645">
        <property type="term" value="P:anaerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007059">
        <property type="entry name" value="DmsC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38095">
        <property type="entry name" value="PTHR38095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04976">
        <property type="entry name" value="DmsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="284" mass="30388" checksum="AA68520DEBC258E0" modified="2005-12-06" version="1">MGNGWHEWPLVIFTVLGQCVVGALIVSGIGWFAAKNDADRQHIVRGMFFLCLLMGIGFIASVMHLGSPLRAFNSLNRIGASGLSNEIAAGSIFFAVGGLWWLVAVIGKMPQALGKLWLLVSMALGVIFVWMMACVYQIDTVPTWHNGYTTLAFFLTVLLSGPILAAAILRAARVTFNTTPFAIISVLAQIACAGVIVLQGLSLSSIHSSVQQASALVPDYASLQVWRVVLLCAGLGCWLCPLIRRREPHVAGLILGLILILGGEMIGRVLFYGLHMTVGMAIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G98</accession>
    <name>Q32G98_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_1520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G98"/>
    <dbReference type="STRING" id="300267.SDY_1520"/>
    <dbReference type="EnsemblBacteria" id="ABB61657">
        <property type="protein sequence ID" value="ABB61657"/>
        <property type="gene ID" value="SDY_1520"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1520"/>
    <dbReference type="HOGENOM" id="CLU_026097_1_0_6"/>
    <dbReference type="OMA" id="WQWLSQG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="62"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="472" mass="51695" checksum="D50C1814AC6BE82D" modified="2005-12-06" version="1">MGKCAGTRMATPLRYALIFLLWAMVAVIYASLIPAALTLISPALSLTHWQALFADPQLPQALLATLVSTTIAAVGALLIALLVIVALWPGPKWQRMCTRLPWLLAIPHVAFATSALLLFADGGLLYDYFPYFTPPMDKLGIGLGFTLAVKESAFLLWILAAVLSEKRLLQQVIVLDSLGYSRWQCLNWLLLPSVAPALAMAMLAIVAWSLSVVDVAIILGPGNPPTLAVISWQWLTQGDADQQTKGALASLLLMLLLAAYVLLGYLLWCTWRRTIPRVDGVRKPATPLLPGITLASFLPLTGVLCVVLLAILADQSTINSEALINSLTMGLVATFIALLLLLLWLEWGTQRRQLWLWLPILLPALQLVAGQYTLALWLNMDGSWTAVVWGHLLWVMPWMLFILQPAWQRIDSRLILIAQTLGFVAGQNLLLREMSANATPYTDCLRGGIFSQYCAVYADAVAGRGAFSDAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GC0</accession>
    <name>Q32GC0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GC0"/>
    <dbReference type="STRING" id="300267.SDY_1496"/>
    <dbReference type="EnsemblBacteria" id="ABB61635">
        <property type="protein sequence ID" value="ABB61635"/>
        <property type="gene ID" value="SDY_1496"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1496"/>
    <dbReference type="HOGENOM" id="CLU_2636084_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="77" mass="8153" checksum="8B96F891EC7715EF" modified="2005-12-06" version="1">MKKIPLGTTDITLSRMGLGTWAIGGGPAWNGDLDRQICIDTILEAHRCGINLIDTAPGYNFGNSEVIVGQAVKKTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GD3</accession>
    <name>Q32GD3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_1483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403113.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GD3"/>
    <dbReference type="STRING" id="300267.SDY_1483"/>
    <dbReference type="EnsemblBacteria" id="ABB61622">
        <property type="protein sequence ID" value="ABB61622"/>
        <property type="gene ID" value="SDY_1483"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1483"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1770"/>
    <dbReference type="HOGENOM" id="CLU_045105_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="292" mass="32958" checksum="4A313A7673E5C0D8" modified="2005-12-06" version="1">MKNTCSTNWKHHQFLLPLIISLLVWAELWFGWSFMIAAGIMFINALFLYRCTFPPHPGRRSPVIKKTTSSTEHRCSIIDLASYTLYGYISMATIYLVSQWLAQYGQFVAGMSYTMSIKLLSIYTVGSLLCVFITAPLIRNTVRPTTLLMLYTFISFIALFTVCLHPTFYVVIIFAFVIGFTSAGGVVQIGLTLMAERFPYAKGKATGIYYSAGSIATFTIPLITAHLSQRSIADIMWFDTAIAAIGFLLALFIGLRSRKKTRHHSLGNDSNLLIVFYVQIMPDDFVMQLHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GG1</accession>
    <name>Q32GG1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4376 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GG1"/>
    <dbReference type="EnsemblBacteria" id="ABB61594">
        <property type="protein sequence ID" value="ABB61594"/>
        <property type="gene ID" value="SDY_1453"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1453"/>
    <dbReference type="HOGENOM" id="CLU_110174_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025484">
        <property type="entry name" value="DUF4376"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14301">
        <property type="entry name" value="DUF4376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4376" evidence="1">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="121" mass="14037" checksum="DAABF0FC18B24AD7" modified="2005-12-06" version="1">MLEAAREARRQGIEAWRTEQEAKPFTFEWNGRIWNAGPNSLGRLYPVVMAAKSDIVRDVMTWGDADNQQVKLSMPELEELAAAMAQAQVERNDEIYRRQRELKEELNSLKDLNSVRNFIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GK2</accession>
    <name>Q32GK2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione-binding protein GsiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_1409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403044.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GK2"/>
    <dbReference type="STRING" id="300267.SDY_1409"/>
    <dbReference type="EnsemblBacteria" id="ABB61553">
        <property type="protein sequence ID" value="ABB61553"/>
        <property type="gene ID" value="SDY_1409"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1409"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1674"/>
    <dbReference type="HOGENOM" id="CLU_017028_0_3_6"/>
    <dbReference type="OMA" id="SSWGDPQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220833" description="Glutathione-binding protein GsiB" evidence="7">
        <location>
            <begin position="30"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="8">
        <location>
            <begin position="84"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="544" mass="60690" checksum="C09870080DE4C8CB" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GR3</accession>
    <name>Q32GR3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Positive transcriptional regulator for cysteine regulon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysB</name>
        <name evidence="3" type="ordered locus">SDY_1345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000776240.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402983.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GR3"/>
    <dbReference type="STRING" id="300267.SDY_1345"/>
    <dbReference type="EnsemblBacteria" id="ABB61492">
        <property type="protein sequence ID" value="ABB61492"/>
        <property type="gene ID" value="SDY_1345"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1345"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1594"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_6"/>
    <dbReference type="OMA" id="FLRTYMY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="324" mass="36159" checksum="CF664FE0512D4C9C" modified="2005-12-06" version="1">MKLQQLRYIVEVVNHNLNVSSTAEGLYTSQPGISKQVRMLEDELGIQIFSRSGKHLTQVTPAGQEIIHIAREVLSKVDAIKSVAGEHTWPDKGSLYIATTHTQARYALPNVIKGFIERYPRVSLHMHQGSPTQIADAVSKGNADFAIATEALHLYEDLVMLPCYHWNRAIVVTPDHPLVGKKAITIEELAQYPLVTYTFGFTGRSELDTAFNRAGLTPRIVFTATDADVIKTYVRLGLGVGVIASMAVDPVADPDLVRVDAHDIFSHSTTKIGFRRSTFLRSYMYDFIQRFAPHLTRDVVDAAVALRSNEEIEVMFKDIKLPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GR7</accession>
    <name>Q32GR7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yciK</name>
        <name evidence="1" type="ordered locus">SDY_1341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000559269.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402979.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GR7"/>
    <dbReference type="STRING" id="300267.SDY_1341"/>
    <dbReference type="EnsemblBacteria" id="ABB61488">
        <property type="protein sequence ID" value="ABB61488"/>
        <property type="gene ID" value="SDY_1341"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1341"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1590"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_6"/>
    <dbReference type="OMA" id="ETGPSFN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="252" mass="28017" checksum="C8C0127BA88869B0" modified="2005-12-06" version="1">MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLRQVASHINEETGRQPQWFILDLLTCRSEDCQQLAQRITVNYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDVIQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRANWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTFDAQPGRKLGISQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H97</accession>
    <name>YEBC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transcriptional regulatory protein YebC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yebC</name>
        <name type="ordered locus">SDY_1151</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000907249.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402799.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H97"/>
    <dbReference type="SMR" id="Q32H97"/>
    <dbReference type="STRING" id="300267.SDY_1151"/>
    <dbReference type="EnsemblBacteria" id="ABB61308">
        <property type="protein sequence ID" value="ABB61308"/>
        <property type="gene ID" value="SDY_1151"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1151"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1355"/>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_6"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000257130" description="Probable transcriptional regulatory protein YebC">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="246" mass="26423" checksum="9D9F71E7DAF78849" modified="2005-12-06" version="1">MAGHSKWANTRHRKAAQDAKRGKIFTKIIRELVTAAKLGGGDPDANPRLRAAVDKALSNNMTRDTLNRAIARGVGGDDDANMETIIYEGYGPGGTAIMIECLSDNRNRTVAEVRHAFSKCGGNLGTDGSVAYLFSKKGVISFEKGDEDTIMEAALEAGAEDVVTYDDGAIDVYTAWEEMGKVRDALEAAGLKADSAEVSMLPSTKADMDAETAPKLMRLIDMLEDCDDVQEVYHNGEISDEVAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HE5</accession>
    <name>Q32HE5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yecS</name>
        <name evidence="11" type="ordered locus">SDY_1099</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001158223.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402751.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HE5"/>
    <dbReference type="STRING" id="300267.SDY_1099"/>
    <dbReference type="EnsemblBacteria" id="ABB61260">
        <property type="protein sequence ID" value="ABB61260"/>
        <property type="gene ID" value="SDY_1099"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1099"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1292"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_4_6"/>
    <dbReference type="OMA" id="EMFAQGK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB61260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="222" mass="24805" checksum="F926C1F1185454C1" modified="2005-12-06" version="1">MQESIQLVIDSLPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYISIFRGTPLIAQLFMIYYGLPQFGIELDPIPSAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTPWQTMRRAILPQAARVALPTLSNSFISLVKDTSLAATIQVPELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSTLQNHFENQLNRQEREPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HE9</accession>
    <name>Q32HE9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor FliA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">RNA polymerase sigma factor for flagellar operon</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sigma F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sigma-28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">fliA</name>
        <name evidence="8" type="ordered locus">SDY_1095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. FliA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001087458.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402747.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HE9"/>
    <dbReference type="STRING" id="300267.SDY_1095"/>
    <dbReference type="EnsemblBacteria" id="ABB61256">
        <property type="protein sequence ID" value="ABB61256"/>
        <property type="gene ID" value="SDY_1095"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1095"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1288"/>
    <dbReference type="HOGENOM" id="CLU_014793_8_1_6"/>
    <dbReference type="OMA" id="IKFETYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00962">
        <property type="entry name" value="Sigma70_FliA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028617">
        <property type="entry name" value="Sigma70_FliA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="96"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="239" mass="27524" checksum="25875C7487FC458D" modified="2005-12-06" version="1">MNSLYTAEGVMDKHSLWQRYVPLVRHEALRLQVRLPASVELDDLLQAGGIGLLNAVERYDALQGTAFTTYAVQCIRGAMLDELRSRDWVPRSVRRNAREVAQAIGQLEQELGRNATETEVAERLGIDIADYRQMLLDTNNSQLFSYDEWREEHGDSIELVTDDYQRENPLQQLLDSNLRQRVMEAIETLPEREKLVLTLYYQEELNLKEIGAELEVGESRVSQLHSQAIKRLRTKLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HI0</accession>
    <name>Q32HI0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HI0"/>
    <dbReference type="STRING" id="300267.SDY_1060"/>
    <dbReference type="EnsemblBacteria" id="ABB61225">
        <property type="protein sequence ID" value="ABB61225"/>
        <property type="gene ID" value="SDY_1060"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1060"/>
    <dbReference type="HOGENOM" id="CLU_046029_0_0_6"/>
    <dbReference type="OMA" id="ANVGPRH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016584">
        <property type="entry name" value="MeTrfase_VrtF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011491">
        <property type="entry name" value="Mtase_YbcY_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="143" mass="15560" checksum="9B5A4D8E4DC6F279" modified="2005-12-06" version="1">MDLNEASLNAASTRAGESKIKHKISHDVFEPYPAALHGQFDSISMFYLLHCLPGNISTKSCVIRNAAQALTDDGTLYGATILGDGVVHNSFGQKLMRIYNQKGIFSNTKDSEEGLTHILSEHFVNVKTKVQGTVVMFSASGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HI8</accession>
    <name>Q32HI8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402708.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HI8"/>
    <dbReference type="STRING" id="300267.SDY_1052"/>
    <dbReference type="EnsemblBacteria" id="ABB61217">
        <property type="protein sequence ID" value="ABB61217"/>
        <property type="gene ID" value="SDY_1052"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1052"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1229"/>
    <dbReference type="HOGENOM" id="CLU_183590_0_0_6"/>
    <dbReference type="OMA" id="GRGSHTW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019669">
        <property type="entry name" value="Uncharacterised_YodD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10733">
        <property type="entry name" value="DUF2525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="80" mass="9183" checksum="ABC807B1F68AA96A" modified="2005-12-06" version="1">MRGKMMKTAKEYSDTAKREVSVDVDALLAAINEISESEVHRSQNDSEHVSVDGREYHTWRELADAFELDIHDFSVSEVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HL3</accession>
    <name>Q32HL3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HL3"/>
    <dbReference type="EnsemblBacteria" id="ABB61192">
        <property type="protein sequence ID" value="ABB61192"/>
        <property type="gene ID" value="SDY_1027"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1027"/>
    <dbReference type="HOGENOM" id="CLU_187537_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="7368" checksum="B08A52C8A46B46A2" modified="2005-12-06" version="1">MKPTLLQTVENICLQILFVLFQFTGTLIDVEGLVSCSSVAKNVQRTPASSVSSSVYSASVSRTAADIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HX8</accession>
    <name>Q32HX8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yejB</name>
        <name evidence="8" type="ordered locus">SDY_0901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000501587.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402568.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HX8"/>
    <dbReference type="STRING" id="300267.SDY_0901"/>
    <dbReference type="EnsemblBacteria" id="ABB61077">
        <property type="protein sequence ID" value="ABB61077"/>
        <property type="gene ID" value="SDY_0901"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0901"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1042"/>
    <dbReference type="HOGENOM" id="CLU_036879_1_1_6"/>
    <dbReference type="OMA" id="TFVVIQF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="133"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="364" mass="40361" checksum="74F309CE76C36E83" modified="2005-12-06" version="1">MGAYLIRRLLLVIPTLWAIITINFFIVQIAPGGPVDQAIAAIEFGNAGVLPGAGGEGVRASHAQTGVGNISDSDYRGGRGLDPEVIAEITHRYGFDKPIHERYFQMLWDYIRFDFGDSLFRSASVLTLIKDSLPVSITLGLWSTLIIYLVSIPLGIRKAVYNGSRFDVWSSAFIIIGYAIPAFLFAILLIVFFAGGSYFDLFPLRGLVSANFDSLPWYQKITDYLWHITLPVLATVIGGFAALTMLTKNSFLDEVRKQYVVTARAKGVSEKNILWKHVFRNAMLLVIAGFPATFISMFFTGSLLIEVMFSLNGLGLLGYEATVSRDYPVMFGTLYIFTLIGLLLNIVSDISYTLVDPRIDFEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HX9</accession>
    <name>Q32HX9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yejE</name>
        <name evidence="9" type="ordered locus">SDY_0900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000088896.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402567.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HX9"/>
    <dbReference type="STRING" id="300267.SDY_0900"/>
    <dbReference type="EnsemblBacteria" id="ABB61076">
        <property type="protein sequence ID" value="ABB61076"/>
        <property type="gene ID" value="SDY_0900"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0900"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1041"/>
    <dbReference type="HOGENOM" id="CLU_028518_4_1_6"/>
    <dbReference type="OMA" id="PSPPTWM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="140"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="341" mass="38110" checksum="ABC6506A32342524" modified="2005-12-06" version="1">MSRLSPVNQARWARFRHNRRGYWSLWIFLVLFGLSLCSELIANDKPLLVRYDGSWYFPLLKNYSESDFGGPLASKADYQDPWLKERLENNGWVLWAPIRFGATSINFATDKPFPSPPSRQNWLGTDANGGDVLARILYGTRISVLFGLMLTLCSSAMGVLAGALQGYYGGKVDLWGQRFIEVWSGMPTLFLIILLSSVVQPNFWWLLAITVLFGWMSLVGVVRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMVTTLTFLPFILCSSITTLTSLDFLGFGLPLGSPSLGELLLQGKNNLQAPWLGITAFLSVAILLSLLIFIGEAIRDAFDPNKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I75</accession>
    <name>Q32I75_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase DinG</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">dinG</name>
        <name evidence="7" type="ordered locus">SDY_0800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent ATPase and 5'-3' DNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the helicase family. DinG subfamily. Type 1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020164.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402471.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I75"/>
    <dbReference type="STRING" id="300267.SDY_0800"/>
    <dbReference type="EnsemblBacteria" id="ABB60982">
        <property type="protein sequence ID" value="ABB60982"/>
        <property type="gene ID" value="SDY_0800"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0800"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.923"/>
    <dbReference type="HOGENOM" id="CLU_012117_4_1_6"/>
    <dbReference type="OMA" id="PRRAQNY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02205">
        <property type="entry name" value="DinG_proteobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039000">
        <property type="entry name" value="DinG_proteobact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
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        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="17"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="716" mass="81442" checksum="01A895A51952E47C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I99</accession>
    <name>Q32I99_SHIDS</name>
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        <submittedName>
            <fullName evidence="1">Putative DNA modification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402447.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I99"/>
    <dbReference type="EnsemblBacteria" id="ABB60958">
        <property type="protein sequence ID" value="ABB60958"/>
        <property type="gene ID" value="SDY_0774"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0774"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.891"/>
    <dbReference type="HOGENOM" id="CLU_080940_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="238" mass="27965" checksum="C8F88F73BA32C00E" modified="2005-12-06" version="1">MGKEKKSRILTKPCVIEYEGRIVGYGSRELRVETISCWLARTIIQTKHYSRRFVNNSWLHLGVFSGRDLVGVLQWGYALNPNSGRRVVLETDNRGYMELNRMWLHDDMPRNSESRAISYALKTIRLLYPSVEWVQSFADERCGRAGVVYQASNFDFIGSHESTFYELDGEWYHEITMNAINRGGKRGEYLRANKERAVAHKFNQYRYIRLLNKRAKKRLNTKLFRIQPYPKTSLISIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IA9</accession>
    <name>Q32IA9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative formate acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ybiW</name>
        <name evidence="6" type="ordered locus">SDY_0764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000209337.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402437.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IA9"/>
    <dbReference type="STRING" id="300267.SDY_0764"/>
    <dbReference type="EnsemblBacteria" id="ABB60948">
        <property type="protein sequence ID" value="ABB60948"/>
        <property type="gene ID" value="SDY_0764"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0764"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.878"/>
    <dbReference type="HOGENOM" id="CLU_009096_0_0_6"/>
    <dbReference type="OMA" id="HVQYNIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010098">
        <property type="entry name" value="PFL2/GDeHydtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01774">
        <property type="entry name" value="PFL2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="5">
        <location>
            <begin position="11"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="4">
        <location>
            <begin position="689"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="677"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="810" mass="90195" checksum="7B9F2A6BD2DAE873" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32II6</accession>
    <name>Q32II6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybgE</name>
        <name evidence="2" type="ordered locus">SDY_0683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000034602.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402360.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32II6"/>
    <dbReference type="STRING" id="300267.SDY_0683"/>
    <dbReference type="EnsemblBacteria" id="ABB60871">
        <property type="protein sequence ID" value="ABB60871"/>
        <property type="gene ID" value="SDY_0683"/>
    </dbReference>
    <dbReference type="GeneID" id="66670995"/>
    <dbReference type="KEGG" id="sdy:SDY_0683"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.797"/>
    <dbReference type="HOGENOM" id="CLU_156555_2_0_6"/>
    <dbReference type="OMA" id="AGCVFWD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011846">
        <property type="entry name" value="Cyd_oper_YbgE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09600">
        <property type="entry name" value="Cyd_oper_YbgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02112">
        <property type="entry name" value="cyd_oper_ybgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="97" mass="10932" checksum="2D34484BE99E8AC9" modified="2005-12-06" version="1">MSKIIATLYAVMDKRPLRALSFVMALLLAGCMFWDPSRFAAKTSELEIWHGLLLMWAVCAGVIHGVGFRPQKVLWQGIFCPLLADIVLIVGLIFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IP1</accession>
    <name>Q32IP1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferric uptake regulation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">fur</name>
        <name evidence="4" type="ordered locus">SDY_0623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000131702.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402305.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IP1"/>
    <dbReference type="SMR" id="Q32IP1"/>
    <dbReference type="STRING" id="300267.SDY_0623"/>
    <dbReference type="EnsemblBacteria" id="ABB60816">
        <property type="protein sequence ID" value="ABB60816"/>
        <property type="gene ID" value="SDY_0623"/>
    </dbReference>
    <dbReference type="GeneID" id="66671047"/>
    <dbReference type="KEGG" id="sdy:SDY_0623"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.724"/>
    <dbReference type="HOGENOM" id="CLU_096072_3_3_6"/>
    <dbReference type="OMA" id="HDHVILT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="148" mass="16795" checksum="B868360513489DD3" modified="2005-12-06" version="1">MTDNNTALKKAGLKVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFELTQQHHHDHLICLDCGKVIEFSDDSIEARQREIAAKHGIRLTNHSLYLYGHCAEGDCREDEHAHEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IQ4</accession>
    <name>Q32IQ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor of N-acetylglucosamine operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nagC</name>
        <name evidence="3" type="ordered locus">SDY_0610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000187594.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402292.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IQ4"/>
    <dbReference type="SMR" id="Q32IQ4"/>
    <dbReference type="STRING" id="300267.SDY_0610"/>
    <dbReference type="EnsemblBacteria" id="ABB60803">
        <property type="protein sequence ID" value="ABB60803"/>
        <property type="gene ID" value="SDY_0610"/>
    </dbReference>
    <dbReference type="GeneID" id="66671054"/>
    <dbReference type="KEGG" id="sdy:SDY_0610"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.706"/>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_6"/>
    <dbReference type="OMA" id="VDFGHTH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="406" mass="44541" checksum="28C4C85D736627C8" modified="2005-12-06" version="1">MTPGGQAQIGNVDLVKQLNSAAVYRLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIKEVDQQASTGGRRAISIVTETRNFHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAIGAFALVKRAMLNGILLQHLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IQ7</accession>
    <name>Q32IQ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IQ7"/>
    <dbReference type="EnsemblBacteria" id="ABB60800">
        <property type="protein sequence ID" value="ABB60800"/>
        <property type="gene ID" value="SDY_0604"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0604"/>
    <dbReference type="HOGENOM" id="CLU_3309634_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="39" mass="4881" checksum="8CAB5A9ED56C96F1" modified="2005-12-06" version="1">MNRLLEEDGWGTWIRTRECRYQKPVPYRLAIPHLYNAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IS3</accession>
    <name>Q32IS3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IS3"/>
    <dbReference type="EnsemblBacteria" id="ABB60784">
        <property type="protein sequence ID" value="ABB60784"/>
        <property type="gene ID" value="SDY_0584"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0584"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_2_6"/>
    <dbReference type="OMA" id="MSSMKLV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="105"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="175" mass="19953" checksum="527C9A46AF0C908E" modified="2005-12-06" version="1">MCQVFGVSRSGYYNWVQHEPSDRKQSDERLKLEIKVAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRSGASAHLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IT0</accession>
    <name>Q32IT0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019777.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402266.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IT0"/>
    <dbReference type="STRING" id="300267.SDY_0577"/>
    <dbReference type="EnsemblBacteria" id="ABB60777">
        <property type="protein sequence ID" value="ABB60777"/>
        <property type="gene ID" value="SDY_0577"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0577"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.677"/>
    <dbReference type="HOGENOM" id="CLU_046670_14_5_6"/>
    <dbReference type="OMA" id="WFVVRRD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018873">
        <property type="entry name" value="KilA-N_DNA-bd_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10543">
        <property type="entry name" value="ORF6N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORF6N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="185" mass="21441" checksum="C8C02A559600E6B6" modified="2005-12-06" version="1">MTTQISVETLSPITHNQIPVITTELLAQLYGTEPVRIRQNHHENKVRFVEGKHFFKVVGNDLKELRVALNYSQNPISPKARSLILWTERGAARHAKMLETDQAWDVFEKLEDCYFRQKDPSAPVSCQKSYDTRVLCYQRGGVTVSTIQLRDDDIVISLESWLELARANGWFVVRRDKLVERLMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IY0</accession>
    <name>Q32IY0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferric enterobactin transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fepG</name>
        <name evidence="8" type="ordered locus">SDY_0520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000640995.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402216.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IY0"/>
    <dbReference type="STRING" id="300267.SDY_0520"/>
    <dbReference type="EnsemblBacteria" id="ABB60727">
        <property type="protein sequence ID" value="ABB60727"/>
        <property type="gene ID" value="SDY_0520"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0520"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.613"/>
    <dbReference type="HOGENOM" id="CLU_013016_1_1_6"/>
    <dbReference type="OMA" id="QRLFMPY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="330" mass="34896" checksum="7413E4F90F9E0974" modified="2005-12-06" version="1">MIYVSRRLLITCLLLVSACVVASIWGLRSGAVTLETSQVFAALMGDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGQDLTAIALAAMAGGIVTSLLVWLLAWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLMMLVAVVLTAAATALAGPISFIALVAPHIARRISGTARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLLIQESRKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J53</accession>
    <name>HTPG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">htpG</name>
        <name type="ordered locus">SDY_0446</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000678219.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402143.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J53"/>
    <dbReference type="SMR" id="Q32J53"/>
    <dbReference type="STRING" id="300267.SDY_0446"/>
    <dbReference type="EnsemblBacteria" id="ABB60654">
        <property type="protein sequence ID" value="ABB60654"/>
        <property type="gene ID" value="SDY_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0446"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.529"/>
    <dbReference type="HOGENOM" id="CLU_006684_3_0_6"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000224232" description="Chaperone protein HtpG">
        <location>
            <begin position="1"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="B" evidence="1">
        <location>
            <begin position="337"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="1">
        <location>
            <begin position="553"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <sequence length="624" mass="71375" checksum="0C0F020214D83F6C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J71</accession>
    <name>Q32J71_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J71"/>
    <dbReference type="SMR" id="Q32J71"/>
    <dbReference type="STRING" id="300267.SDY_0425"/>
    <dbReference type="EnsemblBacteria" id="ABB60636">
        <property type="protein sequence ID" value="ABB60636"/>
        <property type="gene ID" value="SDY_0425"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0425"/>
    <dbReference type="HOGENOM" id="CLU_295073_0_0_6"/>
    <dbReference type="OMA" id="RRSTHHY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041498">
        <property type="entry name" value="Big_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17936">
        <property type="entry name" value="Big_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_6" evidence="1">
        <location>
            <begin position="196"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="2">
        <location>
            <begin position="393"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="2">
        <location>
            <begin position="596"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="2">
        <location>
            <begin position="682"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="2">
        <location>
            <begin position="803"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="958" mass="96626" checksum="DEF47D2A6093C04E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JN2</accession>
    <name>Q32JN2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Damage-inducible protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dinJ</name>
        <name evidence="2" type="ordered locus">SDY_0252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000729709.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401964.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JN2"/>
    <dbReference type="STRING" id="300267.SDY_0252"/>
    <dbReference type="EnsemblBacteria" id="ABB60475">
        <property type="protein sequence ID" value="ABB60475"/>
        <property type="gene ID" value="SDY_0252"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0252"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.283"/>
    <dbReference type="HOGENOM" id="CLU_154558_12_2_6"/>
    <dbReference type="OMA" id="FEVRIPN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026262">
        <property type="entry name" value="DinJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38781">
        <property type="entry name" value="PTHR38781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003108">
        <property type="entry name" value="DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9334" checksum="99FC7A370D90B3E2" modified="2005-12-06" version="1">MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDLFDKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JP2</accession>
    <name>Q32JP2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JP2"/>
    <dbReference type="EnsemblBacteria" id="ABB60465">
        <property type="protein sequence ID" value="ABB60465"/>
        <property type="gene ID" value="SDY_0241"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0241"/>
    <dbReference type="HOGENOM" id="CLU_077365_0_0_6"/>
    <dbReference type="OMA" id="NPRERPQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="201" mass="23154" checksum="BC27EFA5F95990E3" modified="2005-12-06" version="1">MSNHKKWNKYDLLILKSVNEINIHLSSTPYFQPLDWYIIKAMLWTENDAENTSQWNGYPLQIGRFRKDKAMPALISGEKSTALVTPPQWRNKAFNGLKDPERNYWAKEQITGSPEENIKAAITYLMMKLSNTKEESTIDQYDSTLYSAIVQKGDLADNIRKERKTTIPNLTKNNPGKNLDKIHPGDILYYQKASMKVIITG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JT2</accession>
    <name>BAMA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Outer membrane protein assembly factor BamA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bamA</name>
        <name type="synonym">yaeT</name>
        <name type="ordered locus">SDY_0193</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BamA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001240879.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401914.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JT2"/>
    <dbReference type="SMR" id="Q32JT2"/>
    <dbReference type="STRING" id="300267.SDY_0193"/>
    <dbReference type="EnsemblBacteria" id="ABB60425">
        <property type="protein sequence ID" value="ABB60425"/>
        <property type="gene ID" value="SDY_0193"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0193"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.224"/>
    <dbReference type="HOGENOM" id="CLU_007664_1_0_6"/>
    <dbReference type="OMA" id="IFMPAFG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01430">
        <property type="entry name" value="OM_assembly_BamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006076">
        <property type="entry name" value="OM_assembly_OMP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03303">
        <property type="entry name" value="OM_YaeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_1000024390" description="Outer membrane protein assembly factor BamA">
        <location>
            <begin position="21"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA 1" evidence="2">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA 2" evidence="2">
        <location>
            <begin position="92"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA 3" evidence="2">
        <location>
            <begin position="175"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA 4" evidence="2">
        <location>
            <begin position="266"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA 5" evidence="2">
        <location>
            <begin position="347"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01115"/>
        </source>
    </evidence>
    <sequence length="810" mass="90595" checksum="0A0F9AFCDED4BFA8" modified="2005-12-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JW4</accession>
    <name>Q32JW4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Poly(A) polymerase I</fullName>
            <shortName evidence="5">PAP I</shortName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">pcnB</name>
        <name evidence="11" type="ordered locus">SDY_0159</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JW4"/>
    <dbReference type="STRING" id="300267.SDY_0159"/>
    <dbReference type="EnsemblBacteria" id="ABB60393">
        <property type="protein sequence ID" value="ABB60393"/>
        <property type="gene ID" value="SDY_0159"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0159"/>
    <dbReference type="HOGENOM" id="CLU_015961_0_0_6"/>
    <dbReference type="OMA" id="FMAKLDM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004652">
        <property type="term" value="F:polynucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006378">
        <property type="term" value="P:mRNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00957">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010206">
        <property type="entry name" value="PolA_pol_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025866">
        <property type="entry name" value="PolyA_pol_arg_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12626">
        <property type="entry name" value="PolyA_pol_arg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01942">
        <property type="entry name" value="pcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="8">
        <location>
            <begin position="51"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="10">
        <location>
            <begin position="209"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_arg_C" evidence="9">
        <location>
            <begin position="327"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="454" mass="52547" checksum="98869AE7645FCF61" modified="2005-12-06" version="1">MLSREESEAEQAVARPQVTVIPREQHAISRKDISENALKVMYRLNKAGYEAWLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLAHVMFGPEIIEVATFRGHHEGNVSDRTTSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKDGVIRLIGNPETRYREDPVRMLRAVRFAAKLGMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLFPTITRYFTENGDSPMERIIKQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLETAQKIAQESGLTYHDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLLEHPKFRAAYDLLALRAEVERNAELQRLVKWWGEFQVSAPPDQKGMLNELDEEPSPRRRTRRPRKRAPRREGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JZ2</accession>
    <name>Q32JZ2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401854.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JZ2"/>
    <dbReference type="EnsemblBacteria" id="ABB60365">
        <property type="protein sequence ID" value="ABB60365"/>
        <property type="gene ID" value="SDY_0130"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0130"/>
    <dbReference type="HOGENOM" id="CLU_3216340_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="44" mass="4907" checksum="5E1CCDDA8341E6E7" modified="2005-12-06" version="1">MAIFPKAMTGAKNQSSDICLMPHVGLIRRGQRRIRHLVQMSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K19</accession>
    <name>Q32K19_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leu operon leader peptide</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">leu operon attenuator peptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">leuL</name>
        <name evidence="5" type="ordered locus">SDY_0102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in control of the biosynthesis of leucine.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378540.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401827.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K19"/>
    <dbReference type="EnsemblBacteria" id="ABB60338">
        <property type="protein sequence ID" value="ABB60338"/>
        <property type="gene ID" value="SDY_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0102"/>
    <dbReference type="HOGENOM" id="CLU_221572_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012570">
        <property type="entry name" value="Leu_leader"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08054">
        <property type="entry name" value="Leu_leader"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0428">Leader peptide</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="27" mass="3033" checksum="877389479FB21F95" modified="2005-12-06" version="1">MTHIVRFIGLLLNASSLRGRRVSGIQH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K40</accession>
    <name>LPTD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LPS-assembly protein LptD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lptD</name>
        <name type="synonym">imp</name>
        <name type="synonym">ostA</name>
        <name type="ordered locus">SDY_0079</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Contains two intramolecular disulfide bonds.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LptD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000746141.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401806.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K40"/>
    <dbReference type="SMR" id="Q32K40"/>
    <dbReference type="STRING" id="300267.SDY_0079"/>
    <dbReference type="EnsemblBacteria" id="ABB60317">
        <property type="protein sequence ID" value="ABB60317"/>
        <property type="gene ID" value="SDY_0079"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0079"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.89"/>
    <dbReference type="HOGENOM" id="CLU_009039_2_0_6"/>
    <dbReference type="OMA" id="DYSHLDW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015920">
        <property type="term" value="P:lipopolysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010033">
        <property type="term" value="P:response to organic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01411">
        <property type="entry name" value="LPS_assembly_LptD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020889">
        <property type="entry name" value="LipoPS_assembly_LptD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007543">
        <property type="entry name" value="LptD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04453">
        <property type="entry name" value="LptD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000281636" description="LPS-assembly protein LptD">
        <location>
            <begin position="25"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="31"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="173"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01411"/>
        </source>
    </evidence>
    <sequence length="784" mass="89584" checksum="A49ACF6B7C83BEE6" modified="2005-12-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K48</accession>
    <name>Q32K48_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 7">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">folA</name>
        <name evidence="10" type="ordered locus">SDY_0071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020907.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401798.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K48"/>
    <dbReference type="STRING" id="300267.SDY_0071"/>
    <dbReference type="EnsemblBacteria" id="ABB60309">
        <property type="protein sequence ID" value="ABB60309"/>
        <property type="gene ID" value="SDY_0071"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0071"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.81"/>
    <dbReference type="HOGENOM" id="CLU_043966_5_1_6"/>
    <dbReference type="OMA" id="RDNQLPW"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="9">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="159" mass="17998" checksum="8B12D07BB3245F7F" modified="2005-12-06" version="1">MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRYTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLAKAQKLYLTHIDAEVEGDTHFPDYEPNDWESVFSEFHDADAQNSHSYCFEILERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K88</accession>
    <name>Q32K88_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yacK</name>
        <name evidence="7" type="ordered locus">SDY_0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001189581.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401758.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K88"/>
    <dbReference type="SMR" id="Q32K88"/>
    <dbReference type="STRING" id="300267.SDY_0030"/>
    <dbReference type="EnsemblBacteria" id="ABB60270">
        <property type="protein sequence ID" value="ABB60270"/>
        <property type="gene ID" value="SDY_0030"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0030"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.32"/>
    <dbReference type="HOGENOM" id="CLU_009100_2_4_6"/>
    <dbReference type="OMA" id="LLPKQWG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221146" evidence="3">
        <location>
            <begin position="29"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="55"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="227"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="402"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="516" mass="56632" checksum="6FBE966A655BCB0D" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K96</accession>
    <name>Q32K96_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0022</name>
        <name evidence="4" type="ordered locus">SDY_0084</name>
        <name evidence="5" type="ordered locus">SDY_0152</name>
        <name evidence="6" type="ordered locus">SDY_0157</name>
        <name evidence="7" type="ordered locus">SDY_0177</name>
        <name evidence="8" type="ordered locus">SDY_0301</name>
        <name evidence="9" type="ordered locus">SDY_0427</name>
        <name evidence="10" type="ordered locus">SDY_0538</name>
        <name evidence="11" type="ordered locus">SDY_0886</name>
        <name evidence="12" type="ordered locus">SDY_0965</name>
        <name evidence="13" type="ordered locus">SDY_1083</name>
        <name evidence="14" type="ordered locus">SDY_1115</name>
        <name evidence="15" type="ordered locus">SDY_1174</name>
        <name evidence="16" type="ordered locus">SDY_1176</name>
        <name evidence="17" type="ordered locus">SDY_1185</name>
        <name evidence="18" type="ordered locus">SDY_1208</name>
        <name evidence="19" type="ordered locus">SDY_1216</name>
        <name evidence="20" type="ordered locus">SDY_1296</name>
        <name evidence="21" type="ordered locus">SDY_1371</name>
        <name evidence="22" type="ordered locus">SDY_1405</name>
        <name evidence="23" type="ordered locus">SDY_1407</name>
        <name evidence="24" type="ordered locus">SDY_1442</name>
        <name evidence="25" type="ordered locus">SDY_1473</name>
        <name evidence="26" type="ordered locus">SDY_1680</name>
        <name evidence="27" type="ordered locus">SDY_1704</name>
        <name evidence="28" type="ordered locus">SDY_1843</name>
        <name evidence="29" type="ordered locus">SDY_2175</name>
        <name evidence="30" type="ordered locus">SDY_2232</name>
        <name evidence="31" type="ordered locus">SDY_2238</name>
        <name evidence="32" type="ordered locus">SDY_2267</name>
        <name evidence="33" type="ordered locus">SDY_2469</name>
        <name evidence="34" type="ordered locus">SDY_2739</name>
        <name evidence="35" type="ordered locus">SDY_2847</name>
        <name evidence="36" type="ordered locus">SDY_2986</name>
        <name evidence="37" type="ordered locus">SDY_3019</name>
        <name evidence="38" type="ordered locus">SDY_3166</name>
        <name evidence="39" type="ordered locus">SDY_3182</name>
        <name evidence="40" type="ordered locus">SDY_3317</name>
        <name evidence="41" type="ordered locus">SDY_3799</name>
        <name evidence="42" type="ordered locus">SDY_3809</name>
        <name evidence="43" type="ordered locus">SDY_3823</name>
        <name evidence="44" type="ordered locus">SDY_4135</name>
        <name evidence="45" type="ordered locus">SDY_4167</name>
        <name evidence="46" type="ordered locus">SDY_4223</name>
        <name evidence="47" type="ordered locus">SDY_4235</name>
        <name evidence="48" type="ordered locus">SDY_4243</name>
        <name evidence="49" type="ordered locus">SDY_4271</name>
        <name evidence="50" type="ordered locus">SDY_4279</name>
        <name evidence="51" type="ordered locus">SDY_4281</name>
        <name evidence="52" type="ordered locus">SDY_4301</name>
        <name evidence="53" type="ordered locus">SDY_4325</name>
        <name evidence="54" type="ordered locus">SDY_4384</name>
        <name evidence="55" type="ordered locus">SDY_4388</name>
        <name evidence="56" type="ordered locus">SDY_4422</name>
        <name evidence="57" type="ordered locus">SDY_4435</name>
        <name evidence="58" type="ordered locus">SDY_4446</name>
        <name evidence="59" type="ordered locus">SDY_4464</name>
        <name evidence="60" type="ordered locus">SDY_4489</name>
        <name evidence="61" type="ordered locus">SDY_4559</name>
        <name evidence="62" type="ordered locus">SDY_4604</name>
        <name evidence="63" type="ordered locus">SDY_4623</name>
        <name evidence="64" type="ordered locus">SDY_P057</name>
        <name evidence="65" type="ordered locus">SDY_P066</name>
        <name evidence="66" type="ordered locus">SDY_P212</name>
    </gene>
    <organism evidence="3 67">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="64 67">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 67" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 67">Sd197</strain>
            <plasmid evidence="67">Plasmid pSD1_197</plasmid>
            <plasmid evidence="64">pSD1_197</plasmid>
            <plasmid evidence="64">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="64" key="2">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="64">Sd197</strain>
            <plasmid evidence="64">pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ABB60322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ABB60520.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="ABB60638.1"/>
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        <property type="protein sequence ID" value="ABB60744.1"/>
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    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61063.1"/>
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    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61137.1"/>
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    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61246.1"/>
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        <property type="protein sequence ID" value="ABB61272.1"/>
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        <property type="protein sequence ID" value="ABB61331.1"/>
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        <property type="protein sequence ID" value="ABB61340.1"/>
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        <property type="protein sequence ID" value="ABB61516.1"/>
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        <property type="protein sequence ID" value="ABB61549.1"/>
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        <property type="protein sequence ID" value="ABB61551.1"/>
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        <property type="protein sequence ID" value="ABB61583.1"/>
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        <property type="protein sequence ID" value="ABB61612.1"/>
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        <property type="protein sequence ID" value="ABB61801.1"/>
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        <property type="protein sequence ID" value="ABB61825.1"/>
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        <property type="protein sequence ID" value="ABB61952.1"/>
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        <property type="protein sequence ID" value="ABB62261.1"/>
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        <property type="protein sequence ID" value="ABB62316.1"/>
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        <property type="protein sequence ID" value="ABB62321.1"/>
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        <property type="protein sequence ID" value="ABB62345.1"/>
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        <property type="protein sequence ID" value="ABB62539.1"/>
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        <property type="protein sequence ID" value="ABB62782.1"/>
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        <property type="protein sequence ID" value="ABB62886.1"/>
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        <property type="protein sequence ID" value="ABB63009.1"/>
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        <property type="protein sequence ID" value="ABB63038.1"/>
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        <property type="protein sequence ID" value="ABB63178.1"/>
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        <property type="protein sequence ID" value="ABB63192.1"/>
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    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63312.1"/>
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        <property type="protein sequence ID" value="ABB63744.1"/>
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    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63754.1"/>
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    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64045.1"/>
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        <property type="protein sequence ID" value="ABB64074.1"/>
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        <property type="protein sequence ID" value="ABB64125.1"/>
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        <property type="protein sequence ID" value="ABB64136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ABB64271.1"/>
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    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401750.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401811.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401875.1">
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    <dbReference type="KEGG" id="sdy:SDY_4243"/>
    <dbReference type="KEGG" id="sdy:SDY_4271"/>
    <dbReference type="KEGG" id="sdy:SDY_4279"/>
    <dbReference type="KEGG" id="sdy:SDY_4281"/>
    <dbReference type="KEGG" id="sdy:SDY_4301"/>
    <dbReference type="KEGG" id="sdy:SDY_4325"/>
    <dbReference type="KEGG" id="sdy:SDY_4384"/>
    <dbReference type="KEGG" id="sdy:SDY_4388"/>
    <dbReference type="KEGG" id="sdy:SDY_4422"/>
    <dbReference type="KEGG" id="sdy:SDY_4435"/>
    <dbReference type="KEGG" id="sdy:SDY_4446"/>
    <dbReference type="KEGG" id="sdy:SDY_4464"/>
    <dbReference type="KEGG" id="sdy:SDY_4489"/>
    <dbReference type="KEGG" id="sdy:SDY_4559"/>
    <dbReference type="KEGG" id="sdy:SDY_4604"/>
    <dbReference type="KEGG" id="sdy:SDY_4623"/>
    <dbReference type="KEGG" id="sdy:SDY_P057"/>
    <dbReference type="KEGG" id="sdy:SDY_P066"/>
    <dbReference type="KEGG" id="sdy:SDY_P212"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1023"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="OMA" id="PFRIGMI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="64" id="KW-0614">Plasmid</keyword>
    <keyword evidence="67" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB61063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB61137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB61246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB61272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB61331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB61332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB61340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB61361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABB61369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ABB61443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ABB61516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ABB61549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ABB61551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ABB61583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ABB61612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="ABB61801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="ABB61825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="ABB61952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="ABB62261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="ABB62316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="ABB62321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="ABB62345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="ABB62539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="ABB62782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="ABB62886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="ABB63009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EMBL" id="ABB63038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="EMBL" id="ABB63178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="EMBL" id="ABB63192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="EMBL" id="ABB63312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="EMBL" id="ABB63744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="EMBL" id="ABB63754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="EMBL" id="ABB63768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="EMBL" id="ABB64045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="EMBL" id="ABB64074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="EMBL" id="ABB64125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="47">
        <source>
            <dbReference type="EMBL" id="ABB64136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="48">
        <source>
            <dbReference type="EMBL" id="ABB64144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="49">
        <source>
            <dbReference type="EMBL" id="ABB64172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="50">
        <source>
            <dbReference type="EMBL" id="ABB64180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="51">
        <source>
            <dbReference type="EMBL" id="ABB64181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="52">
        <source>
            <dbReference type="EMBL" id="ABB64197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="53">
        <source>
            <dbReference type="EMBL" id="ABB64218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="54">
        <source>
            <dbReference type="EMBL" id="ABB64271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="55">
        <source>
            <dbReference type="EMBL" id="ABB64275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="56">
        <source>
            <dbReference type="EMBL" id="ABB64309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="57">
        <source>
            <dbReference type="EMBL" id="ABB64318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="58">
        <source>
            <dbReference type="EMBL" id="ABB64328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="59">
        <source>
            <dbReference type="EMBL" id="ABB64344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="60">
        <source>
            <dbReference type="EMBL" id="ABB64365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="61">
        <source>
            <dbReference type="EMBL" id="ABB64426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="62">
        <source>
            <dbReference type="EMBL" id="ABB64462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="63">
        <source>
            <dbReference type="EMBL" id="ABB64476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="64">
        <source>
            <dbReference type="EMBL" id="ABB64570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="65">
        <source>
            <dbReference type="EMBL" id="ABB64579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="66">
        <source>
            <dbReference type="EMBL" id="ABB64725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="67">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15364" checksum="120534E19751326A" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KA3</accession>
    <name>Q32KA3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gef</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gef</name>
        <name evidence="3" type="ordered locus">SDY_0015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hok/gef family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378534.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401743.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KA3"/>
    <dbReference type="EnsemblBacteria" id="ABB60255">
        <property type="protein sequence ID" value="ABB60255"/>
        <property type="gene ID" value="SDY_0015"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0015"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.15"/>
    <dbReference type="HOGENOM" id="CLU_177638_2_0_6"/>
    <dbReference type="OMA" id="QHKVMIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000021">
        <property type="entry name" value="Hok/gef_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018084">
        <property type="entry name" value="Hok/gef_toxin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01848">
        <property type="entry name" value="HOK_GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00281">
        <property type="entry name" value="HOKGEFTOXIC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00556">
        <property type="entry name" value="HOK_GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU221113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="7771" checksum="ED1F0A97313C65B4" modified="2005-12-06" version="1">MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAAQVTRKDLCEVHIRTGQTEIAVFTAYESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q326M4</accession>
    <name>Q326M4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406222.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326M4"/>
    <dbReference type="EnsemblBacteria" id="ABB64734">
        <property type="protein sequence ID" value="ABB64734"/>
        <property type="gene ID" value="SDY_P221"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P221"/>
    <dbReference type="HOGENOM" id="CLU_1347196_0_0_6"/>
    <dbReference type="OMA" id="TANTEYI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="236" mass="27570" checksum="F3BB18EF99025EF5" modified="2005-12-06" version="1">MSIEIKMISPIKNIKNVFPINTANTEYIVRNIYPRVEHGYFNESPNIYDKKYISGITRSMAQLKIEEFINEKSRRLNYMKTMYSPCPEDFQPISRDEASTPEGSWLTVISGKRPMGQFSVDSLYHPDLHALCELPEISCKIFPKENSDFLYIIVVFRNDSPQGELRANRFIELYDIKREIMQVLRDESPELKSIKSEIIIAREMGELFSYASEEIDSYIKQMNDRLSQIKARMPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q326R1</accession>
    <name>Q326R1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MxiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mxiC</name>
        <name evidence="2" type="ordered locus">SDY_P184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406185.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326R1"/>
    <dbReference type="EnsemblBacteria" id="ABB64697">
        <property type="protein sequence ID" value="ABB64697"/>
        <property type="gene ID" value="SDY_P184"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P184"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5736"/>
    <dbReference type="HOGENOM" id="CLU_056140_1_0_6"/>
    <dbReference type="OMA" id="YASMSML"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010812">
        <property type="entry name" value="HrpJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003520">
        <property type="entry name" value="Invas_InvE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013401">
        <property type="entry name" value="T3SS_LcrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07201">
        <property type="entry name" value="HrpJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01344">
        <property type="entry name" value="INVEPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02568">
        <property type="entry name" value="LcrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HrpJ" evidence="1">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="335" mass="38057" checksum="60CBDBBE4AF1031B" modified="2005-12-06" version="1">MTNSDDGDETADAELDSGLANSKYIDSSDEMASALSSFINRRDLEKLKGTNSDSQERILDGEEDEINHKIFDLKRTLKDNLPLDRDFIDRLKRYFKDPSDQVLALRELLNEKDLTAEQVELLTKIINEIISGSEKSVNAGINSAIQAKLFGNKMKLEPQLLRACYRGFIMGNTSTTDQYIEWLGNFGFNHRHTIVNFVEQSLIVDMDSEKPSCNTYEFGFVLSKLIAIKMIRTSDVIFMKKLESSSLLKDGSLSAEQLLLTLLYIFQYPSESEQILTSVIEVSRASHEDSVVYQTYLSSVNESPHDIFKSESEREIAINILRELVTSAYKKELSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q327L9</accession>
    <name>Q327L9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yjjU</name>
        <name evidence="4" type="ordered locus">SDY_4637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021032.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405977.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327L9"/>
    <dbReference type="STRING" id="300267.SDY_4637"/>
    <dbReference type="EnsemblBacteria" id="ABB64486">
        <property type="protein sequence ID" value="ABB64486"/>
        <property type="gene ID" value="SDY_4637"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4637"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5497"/>
    <dbReference type="HOGENOM" id="CLU_048271_0_1_6"/>
    <dbReference type="OMA" id="DLDWYFD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07208">
        <property type="entry name" value="Pat_hypo_Ecoli_yjju_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045943">
        <property type="entry name" value="DUF6363"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037483">
        <property type="entry name" value="YjjU-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19890">
        <property type="entry name" value="DUF6363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="27"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="357" mass="39860" checksum="8FB02343C16D7151" modified="2005-12-06" version="1">MGQRIPVTLGNIAPLSLRPFQPGRIALVCEGGGQRGIFTAGVLDEFMRAQFNPFDLYLGTSAGAQNLSAYICNQPGYARKVIMRYTTKREFFDPLRFVRGGNLIDLDWLVEATASQMPLQMDTAARLFDSGKSFYMCACRQDDYAPNYFLPTKQNWLDVIRASSAIPGFYRSGVSLEGINYLDGGISDAIPVKEAARQGAKTLVVIRTVPSQMYYTPQWFKRMERWLGDSSLQPLVNLVQHHETSYREIQQFIEKPPGQLRIFEIYPPKPLHSIALGSRIPALREDYKLGRLCGRYFLATVGQLLTEKAPLSRHLVPVVTPESIVIPPAPVANDTLVAEVSDAPQANDPIFNNEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q327N5</accession>
    <name>Q327N5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome replication</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dnaC</name>
        <name evidence="2" type="ordered locus">SDY_4615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000799912.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405961.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327N5"/>
    <dbReference type="STRING" id="300267.SDY_4615"/>
    <dbReference type="EnsemblBacteria" id="ABB64470">
        <property type="protein sequence ID" value="ABB64470"/>
        <property type="gene ID" value="SDY_4615"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4615"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5470"/>
    <dbReference type="HOGENOM" id="CLU_062999_3_1_6"/>
    <dbReference type="OMA" id="VGDLMKR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="98"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="245" mass="27908" checksum="78D0A3FFFED211E4" modified="2005-12-06" version="1">MKNVGDLMQRLQKMMPAHIKPAFKTGEELLAWQKEQGAIRSAALERENRAMKMQRTFNRSGIRPLHQNCSFENYRVECEGQMNALSKARQYVEEFDGNIASFIFSGKPGTGKNHLAAAICNELLLRGKSVLIITVADIMSAMKDTFRNSGTSEEQLLSDLSNVDLLVIDEIGVQTESKYEKVIINQIVDRRSSSKRPTGMLTNSNMEEMTKLLGERVMDRMRLGNSLWVIFNWDSYRSRVTGKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q327P6</accession>
    <name>Q327P6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjiR</name>
        <name evidence="3" type="ordered locus">SDY_4601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000199325.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405950.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327P6"/>
    <dbReference type="STRING" id="300267.SDY_4601"/>
    <dbReference type="EnsemblBacteria" id="ABB64459">
        <property type="protein sequence ID" value="ABB64459"/>
        <property type="gene ID" value="SDY_4601"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4601"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5453"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_6"/>
    <dbReference type="OMA" id="MPEQIMV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="470" mass="53107" checksum="816A52950DDF456A" modified="2005-12-06" version="1">MTRYQHLATLLAERIEQGLYRHGEKLPSVRSLSQEHGVSISTVQQAYQTLETMKLITPQPRSGYFVAQRKAQPPVPPMTRPVQRPVEITQWDQVLDMLVAHSDSSIVPLSKSTPDVETPSLKPLWRELSRVVQHNLQTVLGYDLLAGQRVLREQIARLMLDSGSVVTADDIIITSGCHNSMSLALMAVCKPGDIVAVESPCYYGSMQMLRGMGVKVIEIPTDPETGISVEALELALEQWPIKGIILVPNCNNPLGFIMPDARKRAVLSLAQRHDIVIFEDDVYGELATEYPRPRTIHSWDIDGRVLLCSSFSKSIAPGLRVGWVAPGRYHDKLMHMKYAISSFNVPSTQMAAATFVLEGHYHRHIRRMRQIYQRNLALYTCWIREYFPCEICITRPKGGFLLWIELPEQVDMVCVARQLYRMKIQVAAGSIFSASGKYRNCLRINCALPLSETYREALKQIGEAVYRAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q327R8</accession>
    <name>Q327R8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327R8"/>
    <dbReference type="STRING" id="300267.SDY_4573"/>
    <dbReference type="EnsemblBacteria" id="ABB64437">
        <property type="protein sequence ID" value="ABB64437"/>
        <property type="gene ID" value="SDY_4573"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4573"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="7690" checksum="1C809B41471C2F26" modified="2005-12-06" version="1">MSGDSGGQSSPLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKATAYFAQESLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q328T8</accession>
    <name>Q328T8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjgH</name>
        <name evidence="1" type="ordered locus">SDY_4266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000230271.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405658.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328T8"/>
    <dbReference type="STRING" id="300267.SDY_4266"/>
    <dbReference type="EnsemblBacteria" id="ABB64167">
        <property type="protein sequence ID" value="ABB64167"/>
        <property type="gene ID" value="SDY_4266"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4266"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5028"/>
    <dbReference type="HOGENOM" id="CLU_100715_4_1_6"/>
    <dbReference type="OMA" id="RHALYEE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02198">
        <property type="entry name" value="YjgH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038743">
        <property type="entry name" value="YjgH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="14592" checksum="4861C905AE24DDC4" modified="2005-12-06" version="1">MVERTAVFPAGRHSLYAEHRYSAAIRSGDLLFVSGQVGSREDGTPEPDFQQQVRLAFDNLHATLAAAGCTFDDIIDVTSFHTDPEKQFEDIMTVKNEIFSALPYPTWTAVGVTWLAGFDFEIKVIARIPEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q329C6</accession>
    <name>IBPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small heat shock protein IbpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16 kDa heat shock protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ibpA</name>
        <name type="ordered locus">SDY_4173</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to monomers at high temperatures or high ionic concentrations.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001243437.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405570.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329C6"/>
    <dbReference type="SMR" id="Q329C6"/>
    <dbReference type="STRING" id="300267.SDY_4173"/>
    <dbReference type="EnsemblBacteria" id="ABB64079">
        <property type="protein sequence ID" value="ABB64079"/>
        <property type="gene ID" value="SDY_4173"/>
    </dbReference>
    <dbReference type="GeneID" id="67417682"/>
    <dbReference type="KEGG" id="sdy:SDY_4173"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4907"/>
    <dbReference type="HOGENOM" id="CLU_046737_4_2_6"/>
    <dbReference type="OMA" id="TAHDNML"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06470">
        <property type="entry name" value="ACD_IbpA-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02000">
        <property type="entry name" value="HSP20_IbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037913">
        <property type="entry name" value="ACD_IbpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023728">
        <property type="entry name" value="HSP20_IbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_1000022024" description="Small heat shock protein IbpA">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="sHSP" evidence="2">
        <location>
            <begin position="28"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <sequence length="137" mass="15774" checksum="E7BB51421F5CEF3E" modified="2005-12-06" version="1">MRNFDLSPLYRSAIGFDRLFNHLENNQSQSNGGYPPYNVELVDENHYRIAIAVAGFAESELEITAQDNLLVVKGAHADEQKERTYLYQGIAERNFERKFQLAENIHVRGANLVNGLLYIDLERVIPEAKKPRRIEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q329C7</accession>
    <name>Q329C7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small heat shock protein IbpB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">16 kDa heat shock protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">ibpB</name>
        <name evidence="7" type="ordered locus">SDY_4172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to oligomers at high temperatures or high ionic concentrations. The decrease in size of the multimers is accompanied by an increase in chaperone activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 5">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329C7"/>
    <dbReference type="STRING" id="300267.SDY_4172"/>
    <dbReference type="EnsemblBacteria" id="ABB64078">
        <property type="protein sequence ID" value="ABB64078"/>
        <property type="gene ID" value="SDY_4172"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4172"/>
    <dbReference type="HOGENOM" id="CLU_046737_4_2_6"/>
    <dbReference type="OMA" id="SGNEGYP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06470">
        <property type="entry name" value="ACD_IbpA-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02001">
        <property type="entry name" value="HSP20_IbpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037913">
        <property type="entry name" value="ACD_IbpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022848">
        <property type="entry name" value="HSP20_IbpB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="6">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="144" mass="16325" checksum="7BB3CA2BB7F23A29" modified="2005-12-06" version="1">MTMRNFDLSPLMRQWIGFDKLANALQNAGESQSFPPYNIEKSDDNHYRITLALAGFRQEDLEIQLEGTRLSVKGTPEQPKEEKKWLHQGLMNQPFSLSFTLAENMEVSGATFVNGLLHIDLIRNEPEPIAAQRIAISERPALNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q329G6</accession>
    <name>Q329G6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative permease of ribose ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_4129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329G6"/>
    <dbReference type="STRING" id="300267.SDY_4129"/>
    <dbReference type="EnsemblBacteria" id="ABB64039">
        <property type="protein sequence ID" value="ABB64039"/>
        <property type="gene ID" value="SDY_4129"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4129"/>
    <dbReference type="HOGENOM" id="CLU_028880_6_0_6"/>
    <dbReference type="OMA" id="FEWIGNG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="236" mass="24823" checksum="48DEAD22730E8DD9" modified="2005-12-06" version="1">MVVSLSPEFAMLSIPAALMLGLLLGLFNGALVAFAGLPPFIVTLGTYTALRGAAYLLADGTTVINSNINFEWIGNNYLGPVPWLVVIALAVIVVCWFILRRTTLGVHIYAVGGNMQAARLTGIKVWLVLLFVYGMSGLLSGLGGIMSASRLYSANGNLGMGYELDAIAAVILSGTSFVGGIGTITGTLVGALIIATLNNGMTLMGASYFWQLVIKGAVIIIAVLIDKYRTRHHQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q329H6</accession>
    <name>Q329H6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding component of phosphonate transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">phnK</name>
        <name evidence="5" type="ordered locus">SDY_4119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001075521.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405520.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329H6"/>
    <dbReference type="STRING" id="300267.SDY_4119"/>
    <dbReference type="EnsemblBacteria" id="ABB64029">
        <property type="protein sequence ID" value="ABB64029"/>
        <property type="gene ID" value="SDY_4119"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4119"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4843"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_6"/>
    <dbReference type="OMA" id="LAICHRT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012700">
        <property type="entry name" value="CP_lyase_PhnK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037116">
        <property type="entry name" value="CP_lyase_PhnK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02323">
        <property type="entry name" value="CP_lyasePhnK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="252" mass="27832" checksum="96FFE1F23F9F83B5" modified="2005-12-06" version="1">MNQPLLSVNNLTHLYAPGKGFSDVSFDLWPGEVLGIVGESGSGKTTLLKSISARLTPQQGEIHYENRSLYGMSEADRRRLLRTEWGVVHQHPLDGLRRQVSAGGNIGERQMATGARHYGDIRATAQKWLEEVEIPANRIDDLPTTFSGGMQQRLQIARNLVTHPKLVFMDEPTGGLDVSVQARLLDLLRGLVVELNLAVVIVTHDLGVARLLADRLLVMKQGQVVESGLTDRVLDDPHHPYTQLLVSSVLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q329J2</accession>
    <name>Q329J2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yjdB</name>
        <name evidence="10" type="ordered locus">SDY_4099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405504.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329J2"/>
    <dbReference type="STRING" id="300267.SDY_4099"/>
    <dbReference type="EnsemblBacteria" id="ABB64013">
        <property type="protein sequence ID" value="ABB64013"/>
        <property type="gene ID" value="SDY_4099"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4099"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4822"/>
    <dbReference type="HOGENOM" id="CLU_018534_1_0_6"/>
    <dbReference type="OMA" id="NSIAFYF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012549">
        <property type="entry name" value="EptA-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040423">
        <property type="entry name" value="PEA_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30443">
        <property type="entry name" value="PTHR30443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08019">
        <property type="entry name" value="EptA_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="EptA_B_N" evidence="9">
        <location>
            <begin position="74"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="8">
        <location>
            <begin position="253"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="562" mass="63431" checksum="FD8C8FE6A8F6E199" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q329K2</accession>
    <name>Q329K2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yicE</name>
        <name evidence="8" type="ordered locus">SDY_4086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378928.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405494.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329K2"/>
    <dbReference type="STRING" id="300267.SDY_4086"/>
    <dbReference type="EnsemblBacteria" id="ABB64003">
        <property type="protein sequence ID" value="ABB64003"/>
        <property type="gene ID" value="SDY_4086"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4086"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4807"/>
    <dbReference type="HOGENOM" id="CLU_017959_8_0_6"/>
    <dbReference type="OMA" id="WANEMPL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="463" mass="48842" checksum="2C88EDBA6B035F65" modified="2005-12-06" version="1">MSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLVSGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMGMLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMSTSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLAVGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q329P3</accession>
    <name>Q329P3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yibN</name>
        <name evidence="3" type="ordered locus">SDY_4044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001368341.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405453.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329P3"/>
    <dbReference type="STRING" id="300267.SDY_4044"/>
    <dbReference type="EnsemblBacteria" id="ABB63962">
        <property type="protein sequence ID" value="ABB63962"/>
        <property type="gene ID" value="SDY_4044"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4044"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4759"/>
    <dbReference type="HOGENOM" id="CLU_089574_1_5_6"/>
    <dbReference type="OMA" id="HKAQPVI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="50"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="143" mass="15582" checksum="C4025BEA5404A857" modified="2005-12-06" version="1">MQEIMQFVGRHPILSIAWIALLVAVLVTTFKSLTSKVKVISRGEATRLINKEDAVVVDLRQRDDFRKGHIAGSINLLPSEIKANNVGELEKHKDKPVIVVDGSGMQCQEPANALTKAGFAQVFVLKEGVAGWAGENLPLVRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Q5</accession>
    <name>Q329Q5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Q5"/>
    <dbReference type="STRING" id="300267.SDY_4032"/>
    <dbReference type="EnsemblBacteria" id="ABB63950">
        <property type="protein sequence ID" value="ABB63950"/>
        <property type="gene ID" value="SDY_4032"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4032"/>
    <dbReference type="HOGENOM" id="CLU_112391_0_0_6"/>
    <dbReference type="OMA" id="HATWGNE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021658">
        <property type="entry name" value="DUF3251"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037125">
        <property type="entry name" value="YajI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11622">
        <property type="entry name" value="DUF3251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3251" evidence="2">
        <location>
            <begin position="67"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="197" mass="22157" checksum="2B05E5E5F70FEFA9" modified="2005-12-06" version="1">MEASPKQQELQKGKIEQLEKQQEQDKRKIELFEKQQTAIISSTKTLASVVKAVKEKQDEFVFTEFNPAQTQYFILNNGSVGLAGRVLAIDAVENGSVIRISLVNLLSVPVSNIGFHATWGNERPTDAKALAKWQQLLFNTALNSTLQLMPGQWQDINLTLKGVSPNNLKYLKLSINMANLQFDTVQSAETRQRKNKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q329S2</accession>
    <name>ATPG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpG</name>
        <name type="ordered locus">SDY_4015</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000896498.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405424.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329S2"/>
    <dbReference type="SMR" id="Q329S2"/>
    <dbReference type="STRING" id="300267.SDY_4015"/>
    <dbReference type="EnsemblBacteria" id="ABB63933">
        <property type="protein sequence ID" value="ABB63933"/>
        <property type="gene ID" value="SDY_4015"/>
    </dbReference>
    <dbReference type="GeneID" id="67417720"/>
    <dbReference type="KEGG" id="sdy:SDY_4015"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4728"/>
    <dbReference type="HOGENOM" id="CLU_050669_0_1_6"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000053336" description="ATP synthase gamma chain">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <sequence length="287" mass="31577" checksum="2417A4B8FBDB8EF8" modified="2005-12-06" version="1">MAGAKEIRSKIASVQNTQKITKAMEMVAASKMRKSQDRMAASRPYAETMRKVIGHLAHGNLEYKHPYLEDRDVKRVGYLVVSTDRGLCGGLNINLFKKLLAEMKTWTDKGVQCDLAMIGSKGVSFFNSVGGNVVAQVTGMGDNPSLSELIGPVKVMLQAYDEGRLDKLYIVSNKFINTMSQVPTISQLLPLPASDDDDLKHKSWDYLYEPDPKALLDTLLRRYVESQVYQGVVENLASEQAARMVAMKAATDNGGSLIKELQLVYNKARQASITQELTEIVSGAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q329T2</accession>
    <name>Q329T2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulator for asnA, asnC and gidA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">asnC</name>
        <name evidence="6" type="ordered locus">SDY_4005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000432970.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405414.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329T2"/>
    <dbReference type="SMR" id="Q329T2"/>
    <dbReference type="STRING" id="300267.SDY_4005"/>
    <dbReference type="EnsemblBacteria" id="ABB63923">
        <property type="protein sequence ID" value="ABB63923"/>
        <property type="gene ID" value="SDY_4005"/>
    </dbReference>
    <dbReference type="GeneID" id="67417730"/>
    <dbReference type="KEGG" id="sdy:SDY_4005"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4717"/>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_6"/>
    <dbReference type="OMA" id="EDCWFIA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="152" mass="16888" checksum="B37581D88D15ECED" modified="2005-12-06" version="1">MENYLIDNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAKDYPSALAKLESLDEVTEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLIVLQNPIMRTIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Z9</accession>
    <name>Q329Z9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 16">Phospholipase A1</fullName>
            <ecNumber evidence="6 16">3.1.1.32</ecNumber>
            <ecNumber evidence="7 16">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylcholine 1-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pldA</name>
        <name evidence="17" type="ordered locus">SDY_3922</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="16">Binds 1 Ca(2+) ion per monomer. In the dimeric form the Ca(2+) is bound by different amino acids with binding of each Ca(2+) shared with ligands coming from each monomer. The Ca(2+) ion may have a role in catalysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 16">Homodimer; dimerization is reversible, and the dimeric form is the active one.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell outer membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="16">One of the very few enzymes located there.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the phospholipase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="6 16"/>
    <dbReference type="EC" id="3.1.1.4" evidence="7 16"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001259700.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405347.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Z9"/>
    <dbReference type="SMR" id="Q329Z9"/>
    <dbReference type="STRING" id="300267.SDY_3922"/>
    <dbReference type="EnsemblBacteria" id="ABB63856">
        <property type="protein sequence ID" value="ABB63856"/>
        <property type="gene ID" value="SDY_3922"/>
    </dbReference>
    <dbReference type="GeneID" id="66672271"/>
    <dbReference type="KEGG" id="sdy:SDY_3922"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4630"/>
    <dbReference type="HOGENOM" id="CLU_045813_1_0_6"/>
    <dbReference type="OMA" id="WGGCRSV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052740">
        <property type="term" value="F:1-acyl-2-lysophosphatidylserine acylhydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052739">
        <property type="term" value="F:phosphatidylserine 1-acylhydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00541">
        <property type="entry name" value="OMPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003187">
        <property type="entry name" value="PLipase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036541">
        <property type="entry name" value="PLipase_A1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40457">
        <property type="entry name" value="PTHR40457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02253">
        <property type="entry name" value="PLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01486">
        <property type="entry name" value="PHPHLIPASEA1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56931">
        <property type="entry name" value="SSF56931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="15 16" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019619922" description="Phospholipase A1" evidence="16">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU366027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB63856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="289" mass="33163" checksum="A688AD32AA60F218" modified="2005-12-06" version="1">MRTLQGWLLPVFMLPMAVYAQEATVKEVHDAPAVRGSIIANMLQEHDNPFTLYPYDTNYLIYTQTSDLNKEAIASYDWAENARKDEVKFQLSLAFPLWRGILGPNSVLGASYTQKSWWQLSNSEESSPFRETNYEPQLFLGFATDYRFAGWTLRDVEMGYNHDSNGRSDPTSRSWNRLYTRLMAENGNWLVEVKPWYVVGNTDDNPDITKYMGYYQLKIGYHLGDAVLSAKGQYNWNTGYGGAELGLSYPITKHVRLYTQVYSGYGESLIDYNFNQTRVGVGVMLNDLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A65</accession>
    <name>FDHD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fdhD</name>
        <name type="ordered locus">SDY_3848</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FdhD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000753591.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405281.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A65"/>
    <dbReference type="SMR" id="Q32A65"/>
    <dbReference type="STRING" id="300267.SDY_3848"/>
    <dbReference type="EnsemblBacteria" id="ABB63790">
        <property type="protein sequence ID" value="ABB63790"/>
        <property type="gene ID" value="SDY_3848"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3848"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4547"/>
    <dbReference type="HOGENOM" id="CLU_056887_2_0_6"/>
    <dbReference type="OMA" id="RYCAGAT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000020819" description="Sulfur carrier protein FdhD">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="260"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <sequence length="277" mass="30562" checksum="782606705EC091E0" modified="2005-12-06" version="1">MKKTQQKEIENVTNITGVRQIELWRRDDLQHPRLDEVAEEVPVALVYNGISHVVMMASPKDLEYFALGFSLSEGIIESPRDIFGMDVVPSCNGLEVQIELSSRRFMGLKERRRALAGRTGCGVCGVEQLNDIGKPVQPLPFTQTFDLNKLDDALRHLNDFQPVGQLTSCTHAAAWMLPSGELVGGHEDVGRHVALDKLLGRRSQEGESWQQGAVLVSSRASYEMVQKSAMCGVEILFAVSAATTLAVEVAERCNLTLVGFCKPGRATVYTHPQRLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AD3</accession>
    <name>Q32AD3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metF</name>
        <name evidence="11" type="ordered locus">SDY_3776</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000007522.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405213.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AD3"/>
    <dbReference type="STRING" id="300267.SDY_3776"/>
    <dbReference type="EnsemblBacteria" id="ABB63722">
        <property type="protein sequence ID" value="ABB63722"/>
        <property type="gene ID" value="SDY_3776"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3776"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4465"/>
    <dbReference type="HOGENOM" id="CLU_025841_0_0_6"/>
    <dbReference type="OMA" id="EMHPQAR"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="296" mass="33113" checksum="B5FDA2D0043BADCE" modified="2005-12-06" version="1">MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVPAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AD8</accession>
    <name>Q32AD8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AD8"/>
    <dbReference type="STRING" id="300267.SDY_3771"/>
    <dbReference type="EnsemblBacteria" id="ABB63717">
        <property type="protein sequence ID" value="ABB63717"/>
        <property type="gene ID" value="SDY_3771"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3771"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_1_6"/>
    <dbReference type="OMA" id="HHPSDEL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="92" mass="10870" checksum="E1CA6BCF7254916A" modified="2005-12-06" version="1">MLTTDEWGSYARELPKEKHLTGKIFTQHIERNNLALRTRIKRLARRTICFSSSVELHEKVIGAFIENICSTNWSHHRFFVVVFMKSSYKTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AE0</accession>
    <name>Q32AE0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AE0"/>
    <dbReference type="STRING" id="300267.SDY_3769"/>
    <dbReference type="EnsemblBacteria" id="ABB63715">
        <property type="protein sequence ID" value="ABB63715"/>
        <property type="gene ID" value="SDY_3769"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3769"/>
    <dbReference type="HOGENOM" id="CLU_2496186_0_0_6"/>
    <dbReference type="OMA" id="RNEPAPY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9417" checksum="A3748B9CC0A1B71A" modified="2005-12-06" version="1">MARFAWQVACKTFGEERAEFGIKPLMGSEDFSFMLEAQPKGGFLLFGNGDVGEGSCMVHNPGYDFNDASLVPASSYWGALVEAWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AJ9</accession>
    <name>Q32AJ9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3 8">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dam</name>
        <name evidence="9" type="ordered locus">SDY_3692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000742144.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405147.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AJ9"/>
    <dbReference type="STRING" id="300267.SDY_3692"/>
    <dbReference type="REBASE" id="11598">
        <property type="entry name" value="M.SdySDamP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63656">
        <property type="protein sequence ID" value="ABB63656"/>
        <property type="gene ID" value="SDY_3692"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3692"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4380"/>
    <dbReference type="HOGENOM" id="CLU_063430_0_1_6"/>
    <dbReference type="OMA" id="MNRHGFN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000398">
        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00571">
        <property type="entry name" value="dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000398-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="278" mass="32099" checksum="B2FA5D12B130EAB9" modified="2005-12-06" version="1">MKKNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDASVVYCDPPYAPLSATANFTAYHTNSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTRKWYQRAKLHVVKVRRSISSNGGTRKKVDELLALYKPGVVSPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AN9</accession>
    <name>Q32AN9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AN9"/>
    <dbReference type="EnsemblBacteria" id="ABB63616">
        <property type="protein sequence ID" value="ABB63616"/>
        <property type="gene ID" value="SDY_3648"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3648"/>
    <dbReference type="HOGENOM" id="CLU_176137_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="111" mass="12584" checksum="2C436F4B97985C64" modified="2005-12-06" version="1">MLVGIRTGLFMVDPLEYHFLHRASENCVAGKYPQFLSACCLATPEFFAILASAVDGFPWTDFIGPISAQLGFALGYYCQWRSKNRCQIRKWSEWGTCLSFVTLGMMAWALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AY6</accession>
    <name>Q32AY6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Acid stress chaperone HdeA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">hdeA</name>
        <name evidence="6" type="ordered locus">SDY_3543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the HdeA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000756550.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405010.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AY6"/>
    <dbReference type="SMR" id="Q32AY6"/>
    <dbReference type="STRING" id="300267.SDY_3543"/>
    <dbReference type="EnsemblBacteria" id="ABB63519">
        <property type="protein sequence ID" value="ABB63519"/>
        <property type="gene ID" value="SDY_3543"/>
    </dbReference>
    <dbReference type="GeneID" id="66672606"/>
    <dbReference type="KEGG" id="sdy:SDY_3543"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4203"/>
    <dbReference type="HOGENOM" id="CLU_170142_1_0_6"/>
    <dbReference type="OMA" id="ACTENKK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990451">
        <property type="term" value="P:cellular stress response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.890.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00946">
        <property type="entry name" value="HdeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024972">
        <property type="entry name" value="HdeA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038303">
        <property type="entry name" value="HdeA/HdeB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036831">
        <property type="entry name" value="HdeA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010486">
        <property type="entry name" value="HNS-dep_expression_A/B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06411">
        <property type="entry name" value="HdeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009564">
        <property type="entry name" value="HNS-dep_expression_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47752">
        <property type="entry name" value="SSF47752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4 5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019117" description="Acid stress chaperone HdeA" evidence="4">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="110" mass="11858" checksum="063262C4863FA2E9" modified="2005-12-06" version="1" precursor="true">MKKVLGVILGGLLLLPVVSNAADAQKAADNKKPVNSWTCEDFLAVDESFQPTAVGFAEALNNKDKPEDAVLDVQGIATVTPAIVQACTQDKQANFKDKVKGEWDKIKKDM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B14</accession>
    <name>KEFG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione-regulated potassium-efflux system ancillary protein KefG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Putative quinone oxidoreductase KefG</fullName>
            <ecNumber evidence="1">1.6.5.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kefG</name>
        <name type="ordered locus">SDY_3513</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + H(+) + NADH = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + H(+) + NADPH = a quinol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with KefB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404982.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B14"/>
    <dbReference type="SMR" id="Q32B14"/>
    <dbReference type="STRING" id="300267.SDY_3513"/>
    <dbReference type="EnsemblBacteria" id="ABB63491">
        <property type="protein sequence ID" value="ABB63491"/>
        <property type="gene ID" value="SDY_3513"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3513"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4167"/>
    <dbReference type="HOGENOM" id="CLU_058643_0_1_6"/>
    <dbReference type="OMA" id="RYPMSDI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008753">
        <property type="term" value="F:NADPH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032414">
        <property type="term" value="P:positive regulation of ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901381">
        <property type="term" value="P:positive regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01415">
        <property type="entry name" value="K_H_efflux_KefG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023947">
        <property type="entry name" value="K_H_efflux_KefG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000068483" description="Glutathione-regulated potassium-efflux system ancillary protein KefG">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01415"/>
        </source>
    </evidence>
    <sequence length="184" mass="20949" checksum="B5DA7BF29BC20C6C" modified="2005-12-06" version="1">MMSQPAKVLLLYAHPESQDSVANRVLLKPATQLSNVTAHDLYAHYPDFFIDIPREQALLREHEVIVFQRPLYTYSCPALLKEWLDRVLSRGFASGPGGNQLAGKYWRSVITTGEPESAYRYDALNRYPMSDVLRPFELAAGMCRMHWLSPIIIYWARRQSAQELASHARAYGDWLANPLSPGGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B18</accession>
    <name>SLYX_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein SlyX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">slyX</name>
        <name type="ordered locus">SDY_3509</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SlyX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001153615.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404978.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B18"/>
    <dbReference type="SMR" id="Q32B18"/>
    <dbReference type="STRING" id="300267.SDY_3509"/>
    <dbReference type="EnsemblBacteria" id="ABB63487">
        <property type="protein sequence ID" value="ABB63487"/>
        <property type="gene ID" value="SDY_3509"/>
    </dbReference>
    <dbReference type="GeneID" id="66672772"/>
    <dbReference type="KEGG" id="sdy:SDY_3509"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4163"/>
    <dbReference type="HOGENOM" id="CLU_180796_4_2_6"/>
    <dbReference type="OMA" id="CQLAFQE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00715">
        <property type="entry name" value="SlyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007236">
        <property type="entry name" value="SlyX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36508">
        <property type="entry name" value="PTHR36508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04102">
        <property type="entry name" value="SlyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000227083" description="Protein SlyX">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="72" mass="8214" checksum="A45F68C319AC7B27" modified="2005-12-06" version="1">MQDLSLEARLAELESRLAFQEITIEELNVTVTAHEMEMAKLRDHLRLLTEKLKASQPSNIASQAEETPPPHY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B25</accession>
    <name>RS7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsG</name>
        <name type="ordered locus">SDY_3502</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001138048.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404971.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B25"/>
    <dbReference type="SMR" id="Q32B25"/>
    <dbReference type="STRING" id="300267.SDY_3502"/>
    <dbReference type="EnsemblBacteria" id="ABB63480">
        <property type="protein sequence ID" value="ABB63480"/>
        <property type="gene ID" value="SDY_3502"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3502"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4156"/>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_6"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000226527" description="30S ribosomal protein S7">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17570" checksum="D9282FF9BA8ECFDB" modified="2005-12-06" version="1">MPRRRVIGQRKILPDPKFGSELLAKFVNILMVDGKKSTAESIVYSALETLAQRSGKSELEALEVALENVRPTVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWIVEAARKRGDKSMALRLANELSDAAENKGTAVKKREDVHRMAEANKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BD3</accession>
    <name>Q32BD3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipopolysaccharide export system protein LptA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhbN</name>
        <name evidence="3" type="synonym">lptA</name>
        <name evidence="6" type="ordered locus">SDY_3381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the lipopolysaccharide transport and assembly complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LptA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000669785.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404863.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BD3"/>
    <dbReference type="SMR" id="Q32BD3"/>
    <dbReference type="STRING" id="300267.SDY_3381"/>
    <dbReference type="EnsemblBacteria" id="ABB63372">
        <property type="protein sequence ID" value="ABB63372"/>
        <property type="gene ID" value="SDY_3381"/>
    </dbReference>
    <dbReference type="GeneID" id="67415966"/>
    <dbReference type="KEGG" id="sdy:SDY_3381"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4035"/>
    <dbReference type="HOGENOM" id="CLU_095993_2_1_6"/>
    <dbReference type="OMA" id="VPTQQME"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015920">
        <property type="term" value="P:lipopolysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01914">
        <property type="entry name" value="LPS_assembly_LptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014340">
        <property type="entry name" value="LptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03002">
        <property type="entry name" value="outer_YhbN_LptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019126" description="Lipopolysaccharide export system protein LptA" evidence="3">
        <location>
            <begin position="28"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="OstA-like_N" evidence="5">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="185" mass="20127" checksum="BA69198479C68DC1" modified="2005-12-06" version="1" precursor="true">MKFKTNKLSLNLVLASSLLAASIPAFAVTGDTDQPIHIESDQQSLDMQGNVVTFTGNVIVTQGTIKINADKVVVTRPGGEQGKEVIDGYGKPATFYQMQDNGKPVEGHASQMHYELAKDFVVLTGNAYLQQVDSNIKGDKITYLVKEQKMQAFSDKGKRVTTVLVPSQLQDKNNKGQTPAQKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BL7</accession>
    <name>Q32BL7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yqjF</name>
        <name evidence="7" type="ordered locus">SDY_3290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DoxX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BL7"/>
    <dbReference type="STRING" id="300267.SDY_3290"/>
    <dbReference type="EnsemblBacteria" id="ABB63288">
        <property type="protein sequence ID" value="ABB63288"/>
        <property type="gene ID" value="SDY_3290"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3290"/>
    <dbReference type="HOGENOM" id="CLU_058421_8_3_6"/>
    <dbReference type="OMA" id="FTGLVFH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="183" mass="19656" checksum="FC62BD44E1813710" modified="2005-12-06" version="1">MTSLKTSIKTITYLSDTGCLEIQGASLIDSNDANTAPLHKKTISSLSGAVESMMKKLEDVGVLVARILMPILFITAGWGKITGYAGTQQYMEAMGVPGFMLPLVILLEFGGGLAILFGFLTRTTVLFTAGFTLLTAFLFHSNFAEGVNSLMFMKNLTISGGFLLLAITGPGAYSIDRLLNKKW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BQ6</accession>
    <name>PLSY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">G3P acyltransferase</fullName>
            <shortName evidence="1">GPAT</shortName>
            <ecNumber evidence="1">2.3.1.15</ecNumber>
            <ecNumber evidence="1">2.3.1.n5</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="1">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsY</name>
        <name type="synonym">ygiH</name>
        <name type="ordered locus">SDY_3242</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:15325"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="2.3.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a fatty acyl-[ACP] + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42300"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.n5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.15" evidence="1"/>
    <dbReference type="EC" id="2.3.1.n5" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001272796.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404740.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BQ6"/>
    <dbReference type="SMR" id="Q32BQ6"/>
    <dbReference type="STRING" id="300267.SDY_3242"/>
    <dbReference type="EnsemblBacteria" id="ABB63249">
        <property type="protein sequence ID" value="ABB63249"/>
        <property type="gene ID" value="SDY_3242"/>
    </dbReference>
    <dbReference type="GeneID" id="66673042"/>
    <dbReference type="KEGG" id="sdy:SDY_3242"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3872"/>
    <dbReference type="HOGENOM" id="CLU_081254_0_2_6"/>
    <dbReference type="OMA" id="WRHRGNL"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102420">
        <property type="term" value="F:sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000188445" description="Glycerol-3-phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="3"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="74"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <sequence length="205" mass="22193" checksum="13066C8FBA2543E2" modified="2005-12-06" version="1">MSAIAPGMILIAYLCGSISSAILVCRLCGLPDPRTSGSGNPGATNVLRIGGKGAAVAVLIFDVLKGMLPVWGAYELGVSPFWLGLIAIAACLGHIWPVFFGFKGGKGVATAFGAIAPIGWDLTGVMAGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVSMLSCLILLRHHDNIQRLWRRQETKIWTKFKRKREKDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BS5</accession>
    <name>Q32BS5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LPP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yqhH</name>
        <name evidence="6" type="ordered locus">SDY_3222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000848536.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404721.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BS5"/>
    <dbReference type="STRING" id="300267.SDY_3222"/>
    <dbReference type="EnsemblBacteria" id="ABB63230">
        <property type="protein sequence ID" value="ABB63230"/>
        <property type="gene ID" value="SDY_3222"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3222"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3848"/>
    <dbReference type="HOGENOM" id="CLU_166934_2_1_6"/>
    <dbReference type="OMA" id="CASTTKI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006817">
        <property type="entry name" value="Lipoprotein_leucine-zipper_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016367">
        <property type="entry name" value="MOM_Lpp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38763">
        <property type="entry name" value="PTHR38763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04728">
        <property type="entry name" value="LPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002855">
        <property type="entry name" value="Murein-lipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LPP" evidence="5">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="3">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="3">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002855-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="85" mass="9499" checksum="B3238775460791D5" modified="2005-12-06" version="1">MKTIFTVGAVVLATCVLSGCVNEQKVNQLASNVQTLNAKIARLEQDMKALRPQIYAAKSEANRANTRLDAQDYFDCLRCLRMYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BU2</accession>
    <name>Q32BU2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygiA</name>
        <name evidence="2" type="ordered locus">SDY_3204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404704.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BU2"/>
    <dbReference type="EnsemblBacteria" id="ABB63213">
        <property type="protein sequence ID" value="ABB63213"/>
        <property type="gene ID" value="SDY_3204"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3204"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3829"/>
    <dbReference type="HOGENOM" id="CLU_193048_0_0_6"/>
    <dbReference type="OMA" id="CRSRCCH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9916" checksum="AA0B577D50062020" modified="2005-12-06" version="1">MTTTGLRPRLNVRQRKDTGYLPHSSPFSLQFRPAILYSDGYLPLVPEDKNETDKIHTPRIVPQKLERTPSDTSRSRGCHCFYAGWL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BW6</accession>
    <name>GCSH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gcvH</name>
        <name type="ordered locus">SDY_3177</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="1">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001307993.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404680.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BW6"/>
    <dbReference type="SMR" id="Q32BW6"/>
    <dbReference type="STRING" id="300267.SDY_3177"/>
    <dbReference type="EnsemblBacteria" id="ABB63189">
        <property type="protein sequence ID" value="ABB63189"/>
        <property type="gene ID" value="SDY_3177"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3177"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3795"/>
    <dbReference type="HOGENOM" id="CLU_097408_2_1_6"/>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0450">Lipoyl</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000302438" description="Glycine cleavage system H protein">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01066"/>
        </source>
    </evidence>
    <sequence length="129" mass="13839" checksum="5B248C818BC290D5" modified="2005-12-06" version="1">MSNVPAELKYSKEHEWLRKEADGTYTVGITEHAQELLGDMVFVDLPEVGATVSAGDDCAVAESVKAASDIYAPVSGEIVAVNDVLSDSPELVNSEPYAGGWIFKIKASDESELESLLDATAYEALLEDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BX5</accession>
    <name>RPIA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoriboisomerase A</fullName>
            <shortName evidence="1">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpiA</name>
        <name type="ordered locus">SDY_3168</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000189743.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404671.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BX5"/>
    <dbReference type="SMR" id="Q32BX5"/>
    <dbReference type="STRING" id="300267.SDY_3168"/>
    <dbReference type="EnsemblBacteria" id="ABB63180">
        <property type="protein sequence ID" value="ABB63180"/>
        <property type="gene ID" value="SDY_3168"/>
    </dbReference>
    <dbReference type="GeneID" id="66673209"/>
    <dbReference type="KEGG" id="sdy:SDY_3168"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3785"/>
    <dbReference type="HOGENOM" id="CLU_056590_1_1_6"/>
    <dbReference type="OMA" id="YDWDEVN"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000016998" description="Ribose-5-phosphate isomerase A">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <sequence length="219" mass="22860" checksum="B53C49CC3DB188BC" modified="2005-12-06" version="1">MTQDELKKAVGWAALQYVQPGTIVGVGTGSTAAHFIDALGTMKGQIEGAVSSSDASTEKLKSLGIHVFDLNEVDSLGIYVDGADEINGHMQMIKGGGAALTREKIIASVAEKFICIADASKQVDILGKFPLPVEVIPMARSAVARQLVKLGGRPEYRQGVVTDNGNVILDVHGMEILDPIAMENAINAIPGVVTVGLFANRGADVALIGTPDGVKTIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BY2</accession>
    <name>Q32BY2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yggE</name>
        <name evidence="2" type="ordered locus">SDY_3160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000669834.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404664.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BY2"/>
    <dbReference type="SMR" id="Q32BY2"/>
    <dbReference type="STRING" id="300267.SDY_3160"/>
    <dbReference type="EnsemblBacteria" id="ABB63173">
        <property type="protein sequence ID" value="ABB63173"/>
        <property type="gene ID" value="SDY_3160"/>
    </dbReference>
    <dbReference type="GeneID" id="66673201"/>
    <dbReference type="KEGG" id="sdy:SDY_3160"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3773"/>
    <dbReference type="HOGENOM" id="CLU_080344_3_0_6"/>
    <dbReference type="OMA" id="LPNGPHI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220746" evidence="1">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="246" mass="26635" checksum="92436CA0B3DFA891" modified="2005-12-06" version="1">MKFKVIALAALMGISGMAAQANELPDGPHIVTSGTASVDAVPDIATLAIEVNVAAKDAATAKKQADERVAQYISFLELNQIAKKDISSANLRTQPDYDYQDGKSILKGYRAVRTVEVTLRQLDKLNSLLDGALKAGLNEIRSVSLGVAQPDAYKDKARKAAIDNAIHQAQELANGFHRKLGPVYSVRYHVSNYQPSPMVRMMKADAAPVSAQETYEQAAIQFDDQVDVVFQLEPVDQQPAKTPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C22</accession>
    <name>Q32C22_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein YggU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">yggU</name>
        <name evidence="3" type="ordered locus">SDY_3119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C22"/>
    <dbReference type="STRING" id="300267.SDY_3119"/>
    <dbReference type="EnsemblBacteria" id="ABB63133">
        <property type="protein sequence ID" value="ABB63133"/>
        <property type="gene ID" value="SDY_3119"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3119"/>
    <dbReference type="HOGENOM" id="CLU_130694_5_0_6"/>
    <dbReference type="OMA" id="AANRECC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005228">
        <property type="entry name" value="CHP00251"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00251">
        <property type="entry name" value="TIGR00251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="10802" checksum="3E6A640A75F7A976" modified="2005-12-06" version="1">MDGVMSAVTVNDDGLVLRLYIQPKASRDSIVGLHGDEVKVAITAPPVDGQANGHLVKFLGKQFRVAKSQVVIEKGELGRHKQIKIINPQQIPPEIAALIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C83</accession>
    <name>Q32C83_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">lysA</name>
        <name evidence="7" type="ordered locus">SDY_3055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001120691.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404563.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C83"/>
    <dbReference type="STRING" id="300267.SDY_3055"/>
    <dbReference type="EnsemblBacteria" id="ABB63072">
        <property type="protein sequence ID" value="ABB63072"/>
        <property type="gene ID" value="SDY_3055"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3055"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3660"/>
    <dbReference type="HOGENOM" id="CLU_026444_0_2_6"/>
    <dbReference type="OMA" id="HGNAKSP"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="31"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="33"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="420" mass="46162" checksum="15143F07800E8674" modified="2005-12-06" version="1">MPHSLFSTDTALTAENLLRLPAEFGCPVWVYDAQIIRRQIAALKQFDVVRFAQKACSNIHILRLMREQGVKVDSVSLGEIERALAAGYNPQTHPDDIVFTADVIDQATLERVSELQIPVNAGSVDMLDQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGENSKHGIWYTDLPAALDVIQRHHLQLVGIHMHIGSGVDYAHLEQVCGAMVRQVIEFGQDLQAISAGGGLSIPYQQGEEAVDTEHYYGLWNAARQQIARHLGHPVKLEIEPGRFLVAQSGVLITQVRSVKQMGSRHFVLVDAGFNDLMRPAMYGSYHHISALAADGRSLEHAPTVETVVAGPLCESGDVFTQQEGGNVETRALLEVKAGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNGQARLIRRRQTIEELLALELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C88</accession>
    <name>Q32C88_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_3050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000758655.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404558.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C88"/>
    <dbReference type="SMR" id="Q32C88"/>
    <dbReference type="STRING" id="300267.SDY_3050"/>
    <dbReference type="EnsemblBacteria" id="ABB63067">
        <property type="protein sequence ID" value="ABB63067"/>
        <property type="gene ID" value="SDY_3050"/>
    </dbReference>
    <dbReference type="GeneID" id="67374287"/>
    <dbReference type="KEGG" id="sdy:SDY_3050"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3655"/>
    <dbReference type="HOGENOM" id="CLU_182841_0_1_6"/>
    <dbReference type="OMA" id="AVMISGC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010305">
        <property type="entry name" value="DUF903"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37011">
        <property type="entry name" value="PTHR37011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06004">
        <property type="entry name" value="DUF903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="7877" checksum="7E053CA350712598" modified="2005-12-06" version="1">MKKWAVIISAVGLAFAVSGCSSDYVMATKDGRMILTDGKPEIDDDTGLVSYHDQQGNAMQINRDDVSQIIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CA2</accession>
    <name>Q32CA2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RecBCD enzyme subunit RecD</fullName>
            <ecNumber evidence="10">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Exonuclease V subunit RecD</fullName>
            <shortName evidence="10">ExoV subunit RecD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Helicase/nuclease RecBCD subunit RecD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">recD</name>
        <name evidence="12" type="ordered locus">SDY_3036</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RecD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000775929.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404544.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CA2"/>
    <dbReference type="STRING" id="300267.SDY_3036"/>
    <dbReference type="EnsemblBacteria" id="ABB63053">
        <property type="protein sequence ID" value="ABB63053"/>
        <property type="gene ID" value="SDY_3036"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3036"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3641"/>
    <dbReference type="HOGENOM" id="CLU_007524_1_2_6"/>
    <dbReference type="OMA" id="MIDLEMM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009338">
        <property type="term" value="C:exodeoxyribonuclease V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01487">
        <property type="entry name" value="RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006344">
        <property type="entry name" value="RecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041851">
        <property type="entry name" value="RecD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01447">
        <property type="entry name" value="recD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="163"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="171"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="608" mass="66693" checksum="955BD7946688ACC6" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CB5</accession>
    <name>Q32CB5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-fuculokinase</fullName>
            <ecNumber evidence="4">2.7.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-fuculose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">fucK</name>
        <name evidence="8" type="ordered locus">SDY_3021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the phosphorylation of L-fuculose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-fuculose = ADP + H(+) + L-fuculose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17617"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57846"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.51"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.51" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404531.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CB5"/>
    <dbReference type="STRING" id="300267.SDY_3021"/>
    <dbReference type="EnsemblBacteria" id="ABB63040">
        <property type="protein sequence ID" value="ABB63040"/>
        <property type="gene ID" value="SDY_3021"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3021"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3627"/>
    <dbReference type="HOGENOM" id="CLU_009281_11_2_6"/>
    <dbReference type="OMA" id="SDLWMQI"/>
    <dbReference type="UniPathway" id="UPA00563">
        <property type="reaction ID" value="UER00625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008737">
        <property type="term" value="F:L-fuculokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042355">
        <property type="term" value="P:L-fucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00986">
        <property type="entry name" value="Fuculokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013450">
        <property type="entry name" value="Fuculokinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF60">
        <property type="entry name" value="PTHR10196:SF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02628">
        <property type="entry name" value="fuculo_kin_coli"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="15"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="269"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="482" mass="53270" checksum="1F9B814486F107DE" modified="2005-12-06" version="1">MLSGYIARAIMKQEVILVLDCGATNVRAIAVNRQGKIVARASTPNASDIAMENNTWHQWSLDAILQRFADCCRQINSELTECHIRGIAVTTFGVDGALVDKQGNLLYPIISWKCPRTAAVMDNIEQLISAQRLQAISGVGAFSFNTLYKLVWLKENHPQLLERAHAWLFISSLINHCLTGEFTTDITMAGTSQMLDIQQRDFSPQILQTTGIPRRLFPRLVEAGEQIGSLQNSAAAMLGLPVGIPVISAGHDTQFALFGAGAEQNEPVLSSGTWEILMVRSAQVDTSLLSQYAGSTCELDSQAGLYNPGMQWLASGVLEWVRKLFWTAETPWQMLIEEARLIAPGADGVKMQCDLLSCQNAGWQGVTLNTTRGHFYRAALEGLTAQLQRNLQMLEKIGHFKASELLLVGGGSRNTLWNQIKANMLDIPVKVLDDAETTVAGAALFGWYGVGEFNSPEEARAQIHYQYRYFYPQTEPEFIEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CC9</accession>
    <name>Q32CC9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">barA</name>
        <name evidence="19" type="ordered locus">SDY_3003</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000186450.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404517.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CC9"/>
    <dbReference type="SMR" id="Q32CC9"/>
    <dbReference type="STRING" id="300267.SDY_3003"/>
    <dbReference type="EnsemblBacteria" id="ABB63026">
        <property type="protein sequence ID" value="ABB63026"/>
        <property type="gene ID" value="SDY_3003"/>
    </dbReference>
    <dbReference type="GeneID" id="66673347"/>
    <dbReference type="KEGG" id="sdy:SDY_3003"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3602"/>
    <dbReference type="HOGENOM" id="CLU_000445_104_1_6"/>
    <dbReference type="OMA" id="NGINAMA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019247">
        <property type="entry name" value="Histidine_kinase_BarA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09984">
        <property type="entry name" value="sCache_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="17">
        <location>
            <begin position="200"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="15">
        <location>
            <begin position="299"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="16">
        <location>
            <begin position="669"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="18">
        <location>
            <begin position="822"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="251"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="12">
        <location>
            <position position="718"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="11">
        <location>
            <position position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABB63026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="918" mass="102453" checksum="EA31D6D732F023CD" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CE8</accession>
    <name>Q32CE8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_2984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CE8"/>
    <dbReference type="STRING" id="300267.SDY_2984"/>
    <dbReference type="EnsemblBacteria" id="ABB63007">
        <property type="protein sequence ID" value="ABB63007"/>
        <property type="gene ID" value="SDY_2984"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2984"/>
    <dbReference type="HOGENOM" id="CLU_2720129_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8039" checksum="C9A200147E07F015" modified="2005-12-06" version="1">MVQLEGSENRIAVARGRYIKAIEQYNVTIRKFPAVLTAKVMDYTPKKNYLPDDVAAVSKAPTIDFSQNANAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CI3</accession>
    <name>ISPD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">MEP cytidylyltransferase</fullName>
            <shortName evidence="1">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispD</name>
        <name type="ordered locus">SDY_2946</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000246138.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404463.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CI3"/>
    <dbReference type="SMR" id="Q32CI3"/>
    <dbReference type="STRING" id="300267.SDY_2946"/>
    <dbReference type="EnsemblBacteria" id="ABB62972">
        <property type="protein sequence ID" value="ABB62972"/>
        <property type="gene ID" value="SDY_2946"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2946"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3538"/>
    <dbReference type="HOGENOM" id="CLU_061281_3_1_6"/>
    <dbReference type="OMA" id="ERQHSVY"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000237820" description="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <sequence length="236" mass="25737" checksum="6AD26690AC2CF201" modified="2005-12-06" version="1">MATTHLDVCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKRVVIAISPGDSRFAQLPLANHPQITVVDGGDERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTRTIHQENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CQ2</accession>
    <name>Q32CQ2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin-like protein NrdH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nrdH</name>
        <name evidence="5" type="ordered locus">SDY_2866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Electron transport system for the ribonucleotide reductase system NrdEF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001223220.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404394.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CQ2"/>
    <dbReference type="STRING" id="300267.SDY_2866"/>
    <dbReference type="EnsemblBacteria" id="ABB62903">
        <property type="protein sequence ID" value="ABB62903"/>
        <property type="gene ID" value="SDY_2866"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2866"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3445"/>
    <dbReference type="HOGENOM" id="CLU_026126_9_0_6"/>
    <dbReference type="OMA" id="PACVQCD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011909">
        <property type="entry name" value="GlrX_NrdH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02194">
        <property type="entry name" value="GlrX_NrdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="9093" checksum="7727BF01E2D4C337" modified="2005-12-06" version="1">MRITIYTHSDCVQCHATKRAMENRGFDFEMINVDRVPEAAEALRAQGFRQLPVVIAGDLSWSGFRPDMINRLHPAPHAASA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CV4</accession>
    <name>RNC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease 3</fullName>
            <ecNumber evidence="1">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribonuclease III</fullName>
            <shortName evidence="1">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnc</name>
        <name type="ordered locus">SDY_2808</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001068343.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404342.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CV4"/>
    <dbReference type="SMR" id="Q32CV4"/>
    <dbReference type="STRING" id="300267.SDY_2808"/>
    <dbReference type="EnsemblBacteria" id="ABB62851">
        <property type="protein sequence ID" value="ABB62851"/>
        <property type="gene ID" value="SDY_2808"/>
    </dbReference>
    <dbReference type="GeneID" id="67416946"/>
    <dbReference type="KEGG" id="sdy:SDY_2808"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3383"/>
    <dbReference type="HOGENOM" id="CLU_000907_1_1_6"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000228581" description="Ribonuclease 3">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="1">
        <location>
            <begin position="155"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <sequence length="226" mass="25550" checksum="D9E2858F2E0AA3A5" modified="2005-12-06" version="1">MNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLEFLGDSILSYVIANALYHRFPRVDEGDMSRMRATLVRGNTLAELAREFELGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIQTVEKLILNWYQTRLDEISPGDKQKDPKTRLQEYLQGRHLPLPTYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D25</accession>
    <name>Q32D25_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D25"/>
    <dbReference type="STRING" id="300267.SDY_2737"/>
    <dbReference type="EnsemblBacteria" id="ABB62780">
        <property type="protein sequence ID" value="ABB62780"/>
        <property type="gene ID" value="SDY_2737"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2737"/>
    <dbReference type="HOGENOM" id="CLU_645198_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="470" mass="53843" checksum="4337C7BD67D57DDD" modified="2005-12-06" version="1">MQREKLLRDYPLNATLWWLNWFDGRSESALAQWRGLCQGRDVNALMTAGQLINWGMPTLAAEMLNALDCQRTLPLYLQASLLPKAERGELVAKAIDVFPQFVRFPNTLEEVAALESIEECWFARHLLACFYYNKRSYNKAIALWQRCVEMSPEFADGWRGLAIHAWNKQHDYELASRYLDNAYQLAPQDARLLFERDLLDKLSGATPEKRLARLENNLEIALKRDDMTAELLNLWHLTGQADKAADILATRKFHPWEGGEGKVTSQFILNQLLRAWQHLDARQPQQASELLHDALHYPENLSEGRLPGQTDNDIWFWQAICANAQGDETEATRCLRLAATGDRTINIHSYYNDQPVDYLFWQGMALRLLGEQQIAQQLFSEMKQWAQEMAKTSIEADFFAVSQPDLLSLYGDLQQQHKEKCLMVAMLASAGLGEVAQYESARAELTAINPAWPKAALFTTVMPFIFNYVH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DA4</accession>
    <name>NUDK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>GDP-mannose pyrophosphatase</fullName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GDP-mannose hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GDPMK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nudK</name>
        <name type="ordered locus">SDY_2650</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GDP-alpha-D-mannose + H2O = alpha-D-mannose 1-phosphate + GMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:27978"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">In the dimer, the N-terminal domains are swapped between the two monomers, such that residues of both chains contribute to the active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001301627.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404192.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DA4"/>
    <dbReference type="SMR" id="Q32DA4"/>
    <dbReference type="STRING" id="300267.SDY_2650"/>
    <dbReference type="EnsemblBacteria" id="ABB62701">
        <property type="protein sequence ID" value="ABB62701"/>
        <property type="gene ID" value="SDY_2650"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2650"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3196"/>
    <dbReference type="HOGENOM" id="CLU_062658_6_0_6"/>
    <dbReference type="OMA" id="RTPAACI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004385">
        <property type="entry name" value="NDP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00052">
        <property type="entry name" value="TIGR00052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342501" description="GDP-mannose pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nudix box">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P37128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="191" mass="21745" checksum="B88E6371E2B57E72" modified="2005-12-06" version="1">MTQQITLIKDKILSDNYFTLHNITYDLTRKDGEVIRHKREVYDRGNGATILLYNAKKKTVVLIRQFRVATWVNGNESGQLIETCAGLLDNDEPEVCIRKEAIEETGYEVGEVRKLFELYMSPGGVTELIHFFIAEYSDNQRANAGGGVEDEDIEVLELPFSQALEMIKTGEIRDGKTVLLLNYLQMSHLID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DE0</accession>
    <name>CYSZ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate transporter CysZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysZ</name>
        <name type="ordered locus">SDY_2610</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CysZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000254849.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404156.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DE0"/>
    <dbReference type="SMR" id="Q32DE0"/>
    <dbReference type="STRING" id="300267.SDY_2610"/>
    <dbReference type="EnsemblBacteria" id="ABB62665">
        <property type="protein sequence ID" value="ABB62665"/>
        <property type="gene ID" value="SDY_2610"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2610"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3147"/>
    <dbReference type="HOGENOM" id="CLU_070331_1_0_6"/>
    <dbReference type="OMA" id="PFADDWS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00468">
        <property type="entry name" value="CysZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022985">
        <property type="entry name" value="Sulfate_CysZ"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0764">Sulfate transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000013718" description="Sulfate transporter CysZ">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00468"/>
        </source>
    </evidence>
    <sequence length="253" mass="29404" checksum="4FD6E4A3A9E61399" modified="2005-12-06" version="1">MVSSFTSAPRSGFYYFAQGWKLVSQPRIRRFVILPLLVNILLMGGAFWWLFTQLDVWIPTLMSYVPDWLQWLSYLLWPLAVISVLLVFGYFFSTIANWIAAPFNGLLAEQLEARLTGATPPDTGIFGIMKDVPRIMKREWQKFAWYLPRAIVLLILYFIPGIGQTVAPVLWFLFSAWMLAIQYCDYPFDNHKVPFKEMRTALRTRKITNMQFGALTSLFTMIPLLNLFIMPVAVCGATAMWVDCYRDKHAMWR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DJ4</accession>
    <name>FADJ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acid oxidation complex subunit alpha</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase</fullName>
                <ecNumber evidence="1">4.2.1.17</ecNumber>
                <ecNumber evidence="1">5.1.2.3</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-hydroxyacyl-CoA dehydrogenase</fullName>
                <ecNumber evidence="1">1.1.1.35</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">fadJ</name>
        <name type="ordered locus">SDY_2542</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:21760"/>
            <dbReference type="ChEBI" id="CHEBI:57315"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="EC" id="5.1.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EC" id="5.1.2.3" evidence="1"/>
    <dbReference type="EC" id="1.1.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000425011.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404102.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DJ4"/>
    <dbReference type="SMR" id="Q32DJ4"/>
    <dbReference type="STRING" id="300267.SDY_2542"/>
    <dbReference type="EnsemblBacteria" id="ABB62611">
        <property type="protein sequence ID" value="ABB62611"/>
        <property type="gene ID" value="SDY_2542"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2542"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3060"/>
    <dbReference type="HOGENOM" id="CLU_009834_16_1_6"/>
    <dbReference type="OMA" id="PFRYMDT"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008692">
        <property type="term" value="F:3-hydroxybutyryl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01617">
        <property type="entry name" value="FadJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012802">
        <property type="entry name" value="FadJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02440">
        <property type="entry name" value="FadJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000273988" description="Fatty acid oxidation complex subunit alpha">
        <location>
            <begin position="1"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Enoyl-CoA hydratase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-hydroxyacyl-CoA dehydrogenase" evidence="1">
        <location>
            <begin position="306"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01617"/>
        </source>
    </evidence>
    <sequence length="714" mass="77184" checksum="252F4E52F3133CA7" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DP5</accession>
    <name>Q32DP5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0304 protein YfbU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfbU</name>
        <name evidence="2" type="ordered locus">SDY_2490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0304 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DP5"/>
    <dbReference type="STRING" id="300267.SDY_2490"/>
    <dbReference type="EnsemblBacteria" id="ABB62560">
        <property type="protein sequence ID" value="ABB62560"/>
        <property type="gene ID" value="SDY_2490"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2490"/>
    <dbReference type="HOGENOM" id="CLU_101021_1_0_6"/>
    <dbReference type="OMA" id="MYHALQV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00762">
        <property type="entry name" value="UPF0304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005587">
        <property type="entry name" value="UPF0304_YfbU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023146">
        <property type="entry name" value="YfbU_alpha-helical_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023145">
        <property type="entry name" value="YfbU_helix-hairpin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03887">
        <property type="entry name" value="YfbU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006272">
        <property type="entry name" value="UCP006272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="170" mass="20226" checksum="B38ED8AE06B7FACA" modified="2005-12-06" version="1">MIQESTMEMTNAQRLILSNQYKMMTMLDPANAERYRRLQTIIERGYGLQMRELDREFGELKEETCRTIIDIMEMYHALHVSWSNLQDQQSIDERRVTFLGFDAATEARYLGYVRFMVNVEGRYTHFDAGTHGFNAQTPMWEKYQRMLNVWHACPRQYHLSANEINQIINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DS0</accession>
    <name>Q32DS0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease BN</fullName>
            <shortName evidence="9">RNase BN</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ribonuclease Z homolog</fullName>
            <shortName evidence="9">RNase Z homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">elaC</name>
        <name evidence="9" type="synonym">rbn</name>
        <name evidence="11" type="ordered locus">SDY_2464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNase Z family. RNase BN subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DS0"/>
    <dbReference type="STRING" id="300267.SDY_2464"/>
    <dbReference type="EnsemblBacteria" id="ABB62535">
        <property type="protein sequence ID" value="ABB62535"/>
        <property type="gene ID" value="SDY_2464"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2464"/>
    <dbReference type="HOGENOM" id="CLU_031317_2_0_6"/>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:endoribonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042779">
        <property type="term" value="P:tRNA 3'-trailer cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013469">
        <property type="entry name" value="Rnase_BN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02649">
        <property type="entry name" value="true_RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="10">
        <location>
            <begin position="42"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="10">
        <location>
            <begin position="209"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="311" mass="33728" checksum="6F8D8C458AE98F25" modified="2005-12-06" version="1">MKRDELMELIFLGTSAGVPTRTRNITAILLNLQHPTQSGLWLFDCGEGTQHQLLNTAFNPGKLDKIFISHLHGDHLFGLPGLLCSRSMSGIVQPLTIYGPQGIREFVETALRISGSWTDYPLEIVEIGAGEILDDGLRKVTAYPMEHPLECYGYRIEEHDKPGALNAQALKAAGVPPGPLFQELKAGKTIMLEDGRQINGADYLAAPVPGKALAIFGDTGPCDAALDLAKGVDVMVHEATLDITMEAKANSRGHSSTRQAATLAREAGVGKLIITHVSSRYDDKGCQHLLRECRSIFPATELANDFTVFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DW1</accession>
    <name>Q32DW1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001215754.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403985.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DW1"/>
    <dbReference type="STRING" id="300267.SDY_2421"/>
    <dbReference type="EnsemblBacteria" id="ABB62494">
        <property type="protein sequence ID" value="ABB62494"/>
        <property type="gene ID" value="SDY_2421"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2421"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2919"/>
    <dbReference type="HOGENOM" id="CLU_086914_0_0_6"/>
    <dbReference type="OMA" id="QGPTPRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009558">
        <property type="entry name" value="DUF1175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06672">
        <property type="entry name" value="DUF1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221075" evidence="1">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="186" mass="21228" checksum="C85FE0137F2A2F98" modified="2005-12-06" version="1">MRHGLLALICWLCCVVAHSEMLNVEQSGLFRAWFVRIAQEQFHQGPSPRWYQQDCAGLVRFAANETLKVHDSKWLKSNGLSSQYLPPEMTLTPEQRQLAQNWNQGNGKTGPYVTAINLIQYNSQFIGQDINQALPGDMIFFDQGDAQHLMVWMGRYVIYHTGSATKTDNGMRAVSLQQLMTWKLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DX6</accession>
    <name>Q32DX6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arginine 3rd transport system periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">artI</name>
        <name evidence="9" type="ordered locus">SDY_2405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000756570.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403970.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DX6"/>
    <dbReference type="STRING" id="300267.SDY_2405"/>
    <dbReference type="EnsemblBacteria" id="ABB62479">
        <property type="protein sequence ID" value="ABB62479"/>
        <property type="gene ID" value="SDY_2405"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2405"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2902"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_0_6"/>
    <dbReference type="OMA" id="DTPFENF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005768">
        <property type="entry name" value="Lys_Arg_Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01096">
        <property type="entry name" value="3A0103s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220670" evidence="6">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="7">
        <location>
            <begin position="22"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="8">
        <location>
            <begin position="22"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="243" mass="26988" checksum="45C16B7E5AD112D9" modified="2005-12-06" version="1">MKKVLIAALIAGFSLSATAAETIRFATEASYPPFESIDANNQIVGFDVDLAQALCKEIDATCTFSNQAFDSLIPSLKFRRVEAVMAGMDITPEREKQVLFTTPYYDNSALFVGQQGKYTSVDQLKGKKVGVQNGTTHQKFIMDKHPEITTVPYDSYQNAKLDLQNGRIDGVFGDTAVVTEWLKDNPKLEAVGDKVTDKDYFGTGLGIAVRQGNTELQQKLNTALEKVKKDGTYETIYNKWFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E74</accession>
    <name>Q32E74_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cardiolipin synthase C</fullName>
            <shortName evidence="1">CL synthase</shortName>
            <ecNumber evidence="1">2.7.8.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ymdC</name>
        <name evidence="1" type="synonym">clsC</name>
        <name evidence="3" type="ordered locus">SDY_2304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a cardiolipin + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:42972"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378798.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403872.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E74"/>
    <dbReference type="STRING" id="300267.SDY_2304"/>
    <dbReference type="EnsemblBacteria" id="ABB62381">
        <property type="protein sequence ID" value="ABB62381"/>
        <property type="gene ID" value="SDY_2304"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2304"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2781"/>
    <dbReference type="HOGENOM" id="CLU_026287_0_0_6"/>
    <dbReference type="OMA" id="THRYLRQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090483">
        <property type="term" value="F:phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01918">
        <property type="entry name" value="Cardiolipin_synth_ClsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030871">
        <property type="entry name" value="Cardiolipin_synth_ClsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="493" mass="55945" checksum="BEC5D9543AB2220D" modified="2005-12-06" version="1">MMKKTPTFTKDSLPNKEMNDLPRLASAVLPLCSQHPGQCGLFPLEKSLDAFAARYRLAEMAEHTLDVQYYIWQDDMSGRLLFSALLAAAKRGVRVRLLLDDNNTPGLDDILRLLDSHPRIEVRLFNPFSFRLLRPLGYITDFSRLNRRMHNKSFTVDGVVTLVGGRNIGDAYFGAGEEPLFSDLDVMAIGPVVEDVADDFARYWYCKSVSPLQQVLDVPEGEMADRIELPASWHNDAMTHRYLRKMESSPFINHLVDGTLPLIWTKTRLLSDDPAKGEGKAKRHSLLPQRLFDIMGSPSERIDIISSYFVPTRAGVAQLLRMVRKGVKIAILTNSLAANDVAVVHAGYARWRKKLLHYGVELYELKPTCEQSSTLHDRGITGNSGASLHAKTFSIDGKTVFIGSFNFDPRSTLLNTEMGFVIESETLAQLIDKRFIQSQYDAAWQLRLDRWGRINWVDRHAKKEIILKKEPATSFWKRVMVRLASILPVEWLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E98</accession>
    <name>RCNA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Nickel/cobalt efflux system RcnA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rcnA</name>
        <name type="ordered locus">SDY_2280</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Efflux system for nickel and cobalt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">By nickel and cobalt. Transcriptionally repressed by RcnR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000134651.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403848.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E98"/>
    <dbReference type="STRING" id="300267.SDY_2280"/>
    <dbReference type="EnsemblBacteria" id="ABB62357">
        <property type="protein sequence ID" value="ABB62357"/>
        <property type="gene ID" value="SDY_2280"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2280"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2753"/>
    <dbReference type="HOGENOM" id="CLU_058605_2_0_6"/>
    <dbReference type="OMA" id="HALEPGH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0171">Cobalt transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-0921">Nickel transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000333789" description="Nickel/cobalt efflux system RcnA">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="78"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="108"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="284"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="285" mass="31864" checksum="04415A588F3AF5AF" modified="2005-12-06" version="1">MTEFTTLLQQGSAWFFIPSAILLGALHGLEPGHSKTMMAAFIIAIKGTIKQAVMLGLAATISHTAVVWLIAFGGMVISKRFTAQSAEPWLQLISAVIIISTAFWMFWRTWRGERNWLENMHEHEHDHEHHHHDHEHHQDHDHDHDHEHHHHHEHGDNEEYQDAHARAHANDIKRHFDGREVTNWQILLFGLTGGLIPCPAAITVLLICIQLKALTLGATLVVSFSIGLALTLVTVGVGAAISVQQVAKRWSGFNTLAKRAPYFSSLLIGLVGVYMGVHGFMGIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EE6</accession>
    <name>Q32EE6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator LYSR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yeeY</name>
        <name evidence="3" type="ordered locus">SDY_2224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EE6"/>
    <dbReference type="EnsemblBacteria" id="ABB62309">
        <property type="protein sequence ID" value="ABB62309"/>
        <property type="gene ID" value="SDY_2224"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2224"/>
    <dbReference type="HOGENOM" id="CLU_039613_35_3_6"/>
    <dbReference type="OMA" id="VIRHEYG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="180" mass="20000" checksum="30ED00DFFADB95BB" modified="2005-12-06" version="1">MKPLLDVLMILDALEKEGSFAAASAKLYKTPSALSYTVHKLESDLNIQLLDRSGHRAKFTRTGKMLLEKGREVLHTVRELEKQAIKLHEGWENELVIGVDDTFPFSLLAPLIEAFCQHHSVTRLKFINGVLGGSWDALTQGRADIIVGAMHEPPYSSEFGFSRLGDLEQVFAVAPHHPLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EE8</accession>
    <name>HIS1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="1">ATP-PRT</shortName>
            <shortName evidence="1">ATP-PRTase</shortName>
            <ecNumber evidence="1">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisG</name>
        <name type="ordered locus">SDY_2222</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000131774.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403798.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EE8"/>
    <dbReference type="SMR" id="Q32EE8"/>
    <dbReference type="STRING" id="300267.SDY_2222"/>
    <dbReference type="EnsemblBacteria" id="ABB62307">
        <property type="protein sequence ID" value="ABB62307"/>
        <property type="gene ID" value="SDY_2222"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2222"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2686"/>
    <dbReference type="HOGENOM" id="CLU_038115_1_0_6"/>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000004507" description="ATP phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <sequence length="299" mass="33381" checksum="A0FB3812CA3525B9" modified="2005-12-06" version="1">MTDNTRLRIAMQKSGRLSDDSRELLARCGIKINLHTQRLIAMAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLNRRAQGEDPRYFTLRRLDFGGCRLSLATPIDEAWDGPLSLNGKRIATSYPHLLKRYLDQKGISFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMEESKQQLIDKLLTRIQGVIQARESKYIMMHAPTERLDEVIALLPGAERPTILPLAGDQQRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EI7</accession>
    <name>Q32EI7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mrp</name>
        <name evidence="4" type="ordered locus">SDY_2182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EI7"/>
    <dbReference type="STRING" id="300267.SDY_2182"/>
    <dbReference type="EnsemblBacteria" id="ABB62268">
        <property type="protein sequence ID" value="ABB62268"/>
        <property type="gene ID" value="SDY_2182"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2182"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_0_6"/>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="125"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="379" mass="41077" checksum="26539688F41A4FB4" modified="2005-12-06" version="1">MVYLYKKGVGMNEQSQAKSPEALRAMVAGTLANFQHPTLKHNLTTLKALHHVAWMDNTLHVELVMPFVWHSAFEELKEQCSAELLRITGAKAIDWKLSHNIATLKRVKNQPGINGVKNIIAVSSGKGGVGKSSTAVNLALALAAEGAKVGILDADIYGPSIPTMLGAENQRPTSPDGTHMAPIMSHGLATNSIGYLVTDDNAMVWRGPMASKALMQMLQETLWPDLDYLVLDMPPGTGDIQLTLAQNIPVTGAVVVTTPQDIALIDAKKGIVMFEKVEVPVLGIVENMSVHICSNCGHHEPIFGTGGAEKLAEKYHTQLLGQMPLHISLREDLDKGTPTVISRPESEFTAIYRQLADRVAAQLYWQGEVIPGEISFRAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ER8</accession>
    <name>MTOX_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-methyl-L-tryptophan oxidase</fullName>
            <shortName evidence="1">MTOX</shortName>
            <ecNumber evidence="1">1.5.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">solA</name>
        <name type="ordered locus">SDY_2096</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative demethylation of N-methyl-L-tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(alpha)-methyl-L-tryptophan + O2 = formaldehyde + H2O2 + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:28006"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57283"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MSOX/MTOX family. MTOX subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.5.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000872799.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403678.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ER8"/>
    <dbReference type="SMR" id="Q32ER8"/>
    <dbReference type="STRING" id="300267.SDY_2096"/>
    <dbReference type="EnsemblBacteria" id="ABB62187">
        <property type="protein sequence ID" value="ABB62187"/>
        <property type="gene ID" value="SDY_2096"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2096"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2521"/>
    <dbReference type="HOGENOM" id="CLU_007884_2_1_6"/>
    <dbReference type="OMA" id="EMYSDPV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050131">
        <property type="term" value="F:N-methyl-L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00515">
        <property type="entry name" value="MTOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023493">
        <property type="entry name" value="Me_Trp_Oxase_MTOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PTHR10961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000259024" description="N-methyl-L-tryptophan oxidase">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="S-8alpha-FAD cysteine" evidence="1">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00515"/>
        </source>
    </evidence>
    <sequence length="372" mass="40843" checksum="CB4965F8A6922D15" modified="2005-12-06" version="1">MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHQHGSHHGDTRLIRHAYGEGEKYVPLVLRAQTLWDDLSRHNEDDPIFVRSGVINLGPADSAFLANVAHSAEQWQLNVEKLDAQGIMARWPEIRVPDNYIGLFETDSGFLRSELAIKTWIQLAKEAGCAQLFNCPVTAIRHEDDGVTIETADGEYQAKKAIVCAGTWVKDLLPELPVQPVRKVFAWYQADGRYSVKNKFPAFTGELPNGDQYYGFPAENDALKIGKHNGGLVIHSADERVPFAEVASDGSEAFPFLRNVLPGIGCCLYGAACTYDNSPDEDFIIDTLPGHDNTLLITGLSGHGFKFASVLGEIAADFAQDKKSDFDLTPFRLSRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EY2</accession>
    <name>Q32EY2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Spermidine/putrescine transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potC</name>
        <name evidence="8" type="ordered locus">SDY_2028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000580303.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403614.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EY2"/>
    <dbReference type="STRING" id="300267.SDY_2028"/>
    <dbReference type="EnsemblBacteria" id="ABB62123">
        <property type="protein sequence ID" value="ABB62123"/>
        <property type="gene ID" value="SDY_2028"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2028"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2441"/>
    <dbReference type="HOGENOM" id="CLU_016047_3_0_6"/>
    <dbReference type="OMA" id="NKFGMKW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="60"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="264" mass="29081" checksum="B69E041D90CCAFD8" modified="2005-12-06" version="1">MIGRLLRGGFMTAIYAYLYIPIIILIVNSFNSSRFGINWQGFTTKWYGLLMNNDSLLQAAQHSLTMAVFSATFATLIGSLTAVALYRYRFRGKPFVSGMLFVVMMSPDIVMAISLLVLFMLLGIQLGFWSLLFSHITFCLPFVVVTVYSRLKGFDVRMLEAAKDLGASEFTILRKIILPLAMPAVAAGWVLSFTLSMDDVVVSSFVTGPSYEILPLKIYSMVKVGVSPEVNALATILLVLSLVMVIASQLIARDKTKGNTGDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EZ3</accession>
    <name>Q32EZ3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ymfC</name>
        <name evidence="6" type="ordered locus">SDY_2017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403603.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EZ3"/>
    <dbReference type="STRING" id="300267.SDY_2017"/>
    <dbReference type="EnsemblBacteria" id="ABB62112">
        <property type="protein sequence ID" value="ABB62112"/>
        <property type="gene ID" value="SDY_2017"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2017"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2430"/>
    <dbReference type="HOGENOM" id="CLU_024979_8_0_6"/>
    <dbReference type="OMA" id="HPRTYWV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="5">
        <location>
            <begin position="31"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="207" mass="23646" checksum="9243C5F66E73D416" modified="2005-12-06" version="1">MQKTSFRNHQVKRFSSQRSTRRKPDNQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTNNGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYTLDNLANGEWREATE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F19</accession>
    <name>RSMF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase F</fullName>
            <ecNumber evidence="1">2.1.1.178</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m5C1407 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-C(5)-)-methyltransferase RsmF</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmF</name>
        <name type="ordered locus">SDY_1986</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42756"/>
            <dbReference type="Rhea" id="RHEA-COMP:10223"/>
            <dbReference type="Rhea" id="RHEA-COMP:10224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.178"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62086" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.1.1.178" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62086.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403577.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F19"/>
    <dbReference type="SMR" id="Q32F19"/>
    <dbReference type="STRING" id="300267.SDY_1986"/>
    <dbReference type="EnsemblBacteria" id="ABB62086">
        <property type="protein sequence ID" value="ABB62086"/>
        <property type="gene ID" value="SDY_1986"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1986"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2397"/>
    <dbReference type="HOGENOM" id="CLU_005316_6_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016434">
        <property type="term" value="F:rRNA (cytosine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01579">
        <property type="entry name" value="16SrRNA_methyltr_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027391">
        <property type="entry name" value="Nol1_Nop2_Fmu_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023545">
        <property type="entry name" value="rRNA_ssu_MeTfrase_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13636">
        <property type="entry name" value="Methyltranf_PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000285018" description="Ribosomal RNA small subunit methyltransferase F">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="125"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="479" mass="53384" checksum="F3843CDBBAA553F4" modified="2007-05-01" version="2">MAQHTVYFPDAFLTQMREAMPSTPSFDDFLAACQRPLRRSIRVNTLKISVADFLRLTAPYGWTLTPIPWCEEGFWIERDNEDALPLGSTAEHLSGLFYIQEASSMLPVAALFADGNAPQRVMDIAAAPGSKTTQIAARMNNEGTILANEFSASRVKVLHANISRCGISNVALTHFDGRVFGAAVPEMFDAILLDAPCSGEGVVRKDPDALKNWSPESNQEIAATQRELIDSAFHALRLGGTLVYSTCTLNREENEAVCLWLKETYPDAVEFLPLGDLFPGTNKALTEEGFLHVFPQIYDCEGFFVARLRKTQAIPALPTPKYKVGNFPFSPVKDREAGQIRQAAASVGLNWDENLRPWQRDKELWLFPVGIEALIGKVRFSRLGIKLAETHNKGYRWQHEAVIALASPDNENAFELTPQEAEEWYRGRDVYPQAAPVADDVLVTFQHQPIGLAKRIGSRLKNSYPRELVRDGKLFTSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F21</accession>
    <name>Q32F21_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403575.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F21"/>
    <dbReference type="STRING" id="300267.SDY_1984"/>
    <dbReference type="EnsemblBacteria" id="ABB62084">
        <property type="protein sequence ID" value="ABB62084"/>
        <property type="gene ID" value="SDY_1984"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1984"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2395"/>
    <dbReference type="HOGENOM" id="CLU_041903_2_2_6"/>
    <dbReference type="OMA" id="VELIGYW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007498">
        <property type="entry name" value="PqiA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04403">
        <property type="entry name" value="PqiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="145" mass="16194" checksum="6B269F3644F2C92D" modified="2005-12-06" version="1">MPISIIYLNGGRQEDTILSGIMSLASSNIAVAGIVFIASILVPFTKVIVMFTLLLSIHFKCQQGLRTRILLLRMVTWIGRWSMLDLFVISLTMSLINRDQILAFTMGPAAFYFGAAVILTILAVEWLDSRLLWDAHESGNARFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F81</accession>
    <name>Q32F81_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403515.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F81"/>
    <dbReference type="STRING" id="300267.SDY_1918"/>
    <dbReference type="EnsemblBacteria" id="ABB62024">
        <property type="protein sequence ID" value="ABB62024"/>
        <property type="gene ID" value="SDY_1918"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1918"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2309"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="FTSMEWA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="115"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="282" mass="32749" checksum="1036CCD37D3289AC" modified="2005-12-06" version="1">MATNNFPIEAMCQVFGVSRSGYYNWVQHEPSDRKQSDERLKLEIKVAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQLGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F96</accession>
    <name>Q32F96_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F96"/>
    <dbReference type="EnsemblBacteria" id="ABB62009">
        <property type="protein sequence ID" value="ABB62009"/>
        <property type="gene ID" value="SDY_1903"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1903"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8497" checksum="46598928F41EEB00" modified="2005-12-06" version="1">MITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHKKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FF7</accession>
    <name>Q32FF7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS4 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FF7"/>
    <dbReference type="STRING" id="300267.SDY_1839"/>
    <dbReference type="EnsemblBacteria" id="ABB61948">
        <property type="protein sequence ID" value="ABB61948"/>
        <property type="gene ID" value="SDY_1839"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1839"/>
    <dbReference type="HOGENOM" id="CLU_028400_4_1_6"/>
    <dbReference type="OMA" id="MFDRCYF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="223" mass="25731" checksum="91FE4A0DE1B44015" modified="2005-12-06" version="1">MTSHLLTAAAFGTMKNSENELAEQLIEQTGDNTLMLMDKGYYSLGLLNAWSLAGEHRHWMIPLRKGAQYEEIRKLGKGDHLVKLKTSPQARKKWPGLGNEVTARLLTVTRKGKVCHLLTSMTDAMRFPGGEMADLYSHRWEIELGYREIKQTMQLSRLTLRSKKPELVEQELWGVLLAYNLVRYQMIKMAEHLKGYWPNQLSFSESCGMVMRCRALHRDVYRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FI8</accession>
    <name>BTUC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vitamin B12 import system permease protein BtuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">btuC</name>
        <name type="ordered locus">SDY_1806</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000956510.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403408.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FI8"/>
    <dbReference type="SMR" id="Q32FI8"/>
    <dbReference type="STRING" id="300267.SDY_1806"/>
    <dbReference type="EnsemblBacteria" id="ABB61917">
        <property type="protein sequence ID" value="ABB61917"/>
        <property type="gene ID" value="SDY_1806"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1806"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2178"/>
    <dbReference type="HOGENOM" id="CLU_013016_0_3_6"/>
    <dbReference type="OMA" id="AMVYWSF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01004">
        <property type="entry name" value="BtuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023691">
        <property type="entry name" value="ABC_transptr_BtuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000062778" description="Vitamin B12 import system permease protein BtuC">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01004"/>
        </source>
    </evidence>
    <sequence length="326" mass="34979" checksum="14D89F2549B0D7CF" modified="2005-12-06" version="1">MLTLARQQQRQNIRWLLCLSVLMLLALLLSLCAGEQWISPGDWFSPRGELFVWQIRLPRTLAVLLVGAALAISGAVMQALFENPLAEPGLLGVSNGAGVGLIAAVLLGQGQLLNWALGLCAIAGALIITLILLRFARRHLSTSRLLLAGVALGIICSALMTWAIYFSTSVDLRQLMYWMMGGFGGVDWRQSWLMLALIPVLLWICCQSRPMNMLALGEISARQLGLPLWFWRNVLVAATGWMVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASALLLADIVARLALAVAELPIGVVTATLGAPVFIWLLLKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FK2</accession>
    <name>Q32FK2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FixC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ydiS</name>
        <name evidence="5" type="ordered locus">SDY_1791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of an electron transfer system.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001278515.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403394.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FK2"/>
    <dbReference type="STRING" id="300267.SDY_1791"/>
    <dbReference type="EnsemblBacteria" id="ABB61903">
        <property type="protein sequence ID" value="ABB61903"/>
        <property type="gene ID" value="SDY_1791"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1791"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2161"/>
    <dbReference type="HOGENOM" id="CLU_050977_0_0_6"/>
    <dbReference type="OMA" id="GGGWMYH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="PTHR43624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="4">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="429" mass="46077" checksum="D65E1A99C5918420" modified="2005-12-06" version="1">MSDDKFDAIVVGAGVAGSVAALVMARAGLDVLVIERGDSAGCKNMTGGRLYAHTLEAIIPGFAASAPVERKVTREKISFLTEESAVTLDFHREQPDVPQHASYTVLRNRLDPWLMGHAEQAGAQFIPGVRVDALVREGNKVTGVQAGDDILEANVVILADGVNSMLGRSLGMVPASDPHHYAVGVKEVIGLTPEQINDRFNITGEEGAAWLFAGSPSDGLMGGGFLYINKDPISLGLVCGLRDIAHAQKSVPQMLEDFKQHPAIRPLISGGKLLEYSAHMVPEGGLAMVPQLVNEGVMIVGDAAGFCLNLGFTVRGMDLAIASAQAAATTMIAAKEREDFSASSLAQYKRELEQSCVMRDMQHFRKIPALMENPRLFSQYPRMVADIMNEMFTIDGKPNQPVRKMIMGHAKKIGLFNLLKDGIKGATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FN9</accession>
    <name>Q32FN9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FN9"/>
    <dbReference type="STRING" id="300267.SDY_1749"/>
    <dbReference type="EnsemblBacteria" id="ABB61866">
        <property type="protein sequence ID" value="ABB61866"/>
        <property type="gene ID" value="SDY_1749"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1749"/>
    <dbReference type="HOGENOM" id="CLU_063479_3_0_6"/>
    <dbReference type="OMA" id="GRIFENA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040831">
        <property type="entry name" value="B_solenoid_ydck_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18836">
        <property type="entry name" value="B_solenoid_ydck"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="144" mass="15751" checksum="7434EDBDCAA5AE87" modified="2005-12-06" version="1">MLLRQIIAISDFNDVIAGTAGGWIDRETVLAQEGNCWIYDQNAIAFGGTVISGNTRITGTSVLWGEVYATDNVWIDNSEISQGAYISDSVTIHDSLVCGQCRIFGHALINQHSMIVAAQGLTPDHQFLLQIYDRARVSASRIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FU2</accession>
    <name>Q32FU2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
            <ecNumber evidence="2">2.7.7.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yeaP</name>
        <name evidence="4" type="ordered locus">SDY_1692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24898"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="2.7.7.65"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403304.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FU2"/>
    <dbReference type="STRING" id="300267.SDY_1692"/>
    <dbReference type="EnsemblBacteria" id="ABB61813">
        <property type="protein sequence ID" value="ABB61813"/>
        <property type="gene ID" value="SDY_1692"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1692"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2039"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_32_6"/>
    <dbReference type="OMA" id="DTLCKRA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="247"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="384" mass="43602" checksum="4F2A7F4A8D086C4F" modified="2005-12-06" version="1">MQHYFYYIHSKHITSCFIFVDDVLSCLQRLNNQHLPAVSWSCSVSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FY1</accession>
    <name>Q32FY1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cryptic nitrate reductase 2, delta subunit, assembly function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">narW</name>
        <name evidence="2" type="ordered locus">SDY_1652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001166373.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403265.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FY1"/>
    <dbReference type="STRING" id="300267.SDY_1652"/>
    <dbReference type="EnsemblBacteria" id="ABB61774">
        <property type="protein sequence ID" value="ABB61774"/>
        <property type="gene ID" value="SDY_1652"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1652"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1992"/>
    <dbReference type="HOGENOM" id="CLU_084469_0_0_6"/>
    <dbReference type="OMA" id="YGDTRKR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="231" mass="26310" checksum="1B194B02B35B984F" modified="2005-12-06" version="1">MQILKVIGLLMEYPDELLWECKEDALALIRRDAPMLTDFTRNQLNAPLLDKQAEWCEVFDRGRTTSLLLFEHVHAESRDRGQAMVDLLAEYEKVDLQLDCRELPDYLPLYLEYLSVLPDDQAREGLLNVAPILALLGGRLKQRKAPWYSLFDALLQLAGSTLSSDSVTKQVNSEERDDTRQALDAVWEEEQVKFIEDNATACDSSPLNQYQRRFSQDVAPQYVDISAGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FY6</accession>
    <name>Q32FY6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FY6"/>
    <dbReference type="EnsemblBacteria" id="ABB61769">
        <property type="protein sequence ID" value="ABB61769"/>
        <property type="gene ID" value="SDY_1645"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1645"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="KGDFTHR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32143" checksum="C36C2C6F84C11205" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGDFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKRIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FZ0</accession>
    <name>Q32FZ0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LPD5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FZ0"/>
    <dbReference type="STRING" id="300267.SDY_1641"/>
    <dbReference type="EnsemblBacteria" id="ABB61765">
        <property type="protein sequence ID" value="ABB61765"/>
        <property type="gene ID" value="SDY_1641"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1641"/>
    <dbReference type="HOGENOM" id="CLU_2669041_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040651">
        <property type="entry name" value="LPD5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18799">
        <property type="entry name" value="LPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LPD5" evidence="1">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8586" checksum="057C6C08DB7E6317" modified="2005-12-06" version="1">MEASPYSLRDSKGRDLFFSESRDELLKKAKAYFDEQGSRERETPATSADDRITFDVYRHKASGDIFIGYGKTGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G30</accession>
    <name>Q32G30_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">marR</name>
        <name evidence="2" type="ordered locus">SDY_1597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G30"/>
    <dbReference type="SMR" id="Q32G30"/>
    <dbReference type="STRING" id="300267.SDY_1597"/>
    <dbReference type="EnsemblBacteria" id="ABB61725">
        <property type="protein sequence ID" value="ABB61725"/>
        <property type="gene ID" value="SDY_1597"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1597"/>
    <dbReference type="HOGENOM" id="CLU_083287_18_5_6"/>
    <dbReference type="OMA" id="YEATMVT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="13902" checksum="EE62D0C4FE2CAA15" modified="2005-12-06" version="1">MVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCHQLVGQDLHQELTKNLTADEVATLEHLLKKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GC8</accession>
    <name>Q32GC8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="10">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gapA</name>
        <name evidence="12" type="ordered locus">SDY_1488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000153502.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403118.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GC8"/>
    <dbReference type="SMR" id="Q32GC8"/>
    <dbReference type="STRING" id="300267.SDY_1488"/>
    <dbReference type="EnsemblBacteria" id="ABB61627">
        <property type="protein sequence ID" value="ABB61627"/>
        <property type="gene ID" value="SDY_1488"/>
    </dbReference>
    <dbReference type="GeneID" id="67415525"/>
    <dbReference type="KEGG" id="sdy:SDY_1488"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1776"/>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_6"/>
    <dbReference type="OMA" id="NCVAPMA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="PTHR10836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="6">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="6">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB61627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="331" mass="35532" checksum="B3A460AA6D59E46D" modified="2005-12-06" version="1">MTIKVGINGFGRIGRIVFRAAQKRSDIEIVAINDLLDADYMAYMLKYDSTHGRFDGTVEVKDGHLIVNGKKIRVTAERDPANLKWDEVGVDVVAEATGLFLTDETARKHITAGAKKVVMTGPSKDNTPMFVKGANFDKYAGQDIVSNASCTTNCLAPLAKVINDNFGIIEGLMTTVHATTATQKTVDGPSHKDWRGGRGASQNIIPSSTGAAKAVGKVLPELNGKLTGMAFRVPTPNVSVVDLTVRLEKAATYEQIKAAVKAAAEGEMKGVLGYTEDDVVSTDFNGEVCTSVFDAKAGIALNDNFVKLVSWYDNETGYSNKVLDLIAHISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GJ5</accession>
    <name>Q32GJ5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ogt</name>
        <name evidence="10" type="ordered locus">SDY_1416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000945008.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403051.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GJ5"/>
    <dbReference type="STRING" id="300267.SDY_1416"/>
    <dbReference type="EnsemblBacteria" id="ABB61560">
        <property type="protein sequence ID" value="ABB61560"/>
        <property type="gene ID" value="SDY_1416"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1416"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1685"/>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_6"/>
    <dbReference type="OMA" id="SACAMNA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="88"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="171" mass="19225" checksum="163B4C72223DFC28" modified="2005-12-06" version="1">MLRLLEEKIATPLGPLWVICDEQFRLRAVEWEEYSERMVQLLDIHYRKEGYERISATNPGGLSDKLRDYFAGNLSIIDTLRTATGGTPFQREVWETLRTIPCGQVMHYGQLAEQLGRPGAARAVGAANGSNPISIVVPCHRVIGRNGTMTGYAGGVQRKEWLLRHEGYLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H06</accession>
    <name>Q32H06_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sigma-54 factor interaction domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402890.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H06"/>
    <dbReference type="STRING" id="300267.SDY_1249"/>
    <dbReference type="EnsemblBacteria" id="ABB61399">
        <property type="protein sequence ID" value="ABB61399"/>
        <property type="gene ID" value="SDY_1249"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1249"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1483"/>
    <dbReference type="HOGENOM" id="CLU_150689_0_0_6"/>
    <dbReference type="OMA" id="GGRMQEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="143" mass="15977" checksum="FD16DAD28E1C329C" modified="2005-12-06" version="1">MRRGSIPALVNNKLRSLEKRFSTRLKIDDDALARLVSCAWPGNDFELYSVIENLALSSDNGRIRVSDLPEHLFTEQATDDVSATRLSTSLSFAEVEKEAIINAAQVTGGRMQEMSALLGIGRTTLWRKMKQHGIDAGQFKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H33</accession>
    <name>Q32H33_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UmuD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">umuD</name>
        <name evidence="9" type="ordered locus">SDY_1220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000897370.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402863.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H33"/>
    <dbReference type="STRING" id="300267.SDY_1220"/>
    <dbReference type="MEROPS" id="S24.003"/>
    <dbReference type="EnsemblBacteria" id="ABB61372">
        <property type="protein sequence ID" value="ABB61372"/>
        <property type="gene ID" value="SDY_1220"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1220"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1448"/>
    <dbReference type="HOGENOM" id="CLU_066192_0_0_6"/>
    <dbReference type="OMA" id="VQIWGVA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="8">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="139" mass="15077" checksum="1361A3FFB99EDA63" modified="2005-12-06" version="1">MLFIKPADLREILTFPLFSDLVQCGFPSPAADYVEQRIDLNQLLIQHPSATYFVKASGDSMIDGGISDGDLLIVDSAITASHGDIVIAAVDGEFTVKKLQLRPTVQLIPMNSAYSPITISSEDTLDVFGVVIHVVKAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H39</accession>
    <name>Q32H39_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0260 protein YcgN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">ycgN</name>
        <name evidence="2" type="ordered locus">SDY_1213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0260 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H39"/>
    <dbReference type="STRING" id="300267.SDY_1213"/>
    <dbReference type="EnsemblBacteria" id="ABB61366">
        <property type="protein sequence ID" value="ABB61366"/>
        <property type="gene ID" value="SDY_1213"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1213"/>
    <dbReference type="HOGENOM" id="CLU_109769_2_0_6"/>
    <dbReference type="OMA" id="GRCCLHK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00676">
        <property type="entry name" value="UPF0260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008228">
        <property type="entry name" value="UCP006173"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37421">
        <property type="entry name" value="PTHR37421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006173">
        <property type="entry name" value="UCP006173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="158" mass="18544" checksum="21EBFD2EFCB3F35E" modified="2005-12-06" version="1">MRFNVMAEHLMSDVPFWQSKTLDEMSDAEWESLCDGCGQCCLHKLMDEDTDEIYFTNVACRQLNIKTCQCRNYDRRFEFEPDCIKLTRENLPTFEWLPMTCAYRLLAEGKDLPAWHPLLTGSKAAMHGERISVRHIAVKESEVIDWQDHILNKPDWAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HG9</accession>
    <name>MTFA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein MtfA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mlc titration factor A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtfA</name>
        <name type="ordered locus">SDY_1072</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the regulation of ptsG expression by binding and inactivating Mlc.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with Mlc.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MtfA family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB61236" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61236.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005023745.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402727.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HG9"/>
    <dbReference type="SMR" id="Q32HG9"/>
    <dbReference type="STRING" id="300267.SDY_1072"/>
    <dbReference type="MEROPS" id="M90.001"/>
    <dbReference type="EnsemblBacteria" id="ABB61236">
        <property type="protein sequence ID" value="ABB61236"/>
        <property type="gene ID" value="SDY_1072"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1072"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1261"/>
    <dbReference type="HOGENOM" id="CLU_063037_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd20169">
        <property type="entry name" value="Peptidase_M90_mtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01593">
        <property type="entry name" value="MtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010384">
        <property type="entry name" value="MtfA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042252">
        <property type="entry name" value="MtfA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30164">
        <property type="entry name" value="PTHR30164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06167">
        <property type="entry name" value="Peptidase_M90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000316324" description="Protein MtfA">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="265" mass="30221" checksum="3CAE3664FCECF8A7" modified="2008-02-05" version="2">MIKWPQKVQESAHQTALPWQEALSIPLLTCLTEQEQSKLVTLAERFLQQKRLVPLQGFELDSLRSCRIALLFCLPVLELGLEWLDGFHEVLIYPAPFVVDDEWEDDIGLVHNQRIVQSGQSWQQGPIVLNWLDIQDSFDASGFNLIIHEVAHKLDTRNGDRASGVPFIPLREVAGWEHDLHAAMNNIQEEIELVGENAASIDAYAASDPAECFAVLSEYFFSAPELFAPRFPSLWQRFCQFYQQDPLQRLHHANDTDSFSATNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HM7</accession>
    <name>Q32HM7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative radC-like protein yeeS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_1013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001186198.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402669.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HM7"/>
    <dbReference type="STRING" id="300267.SDY_1013"/>
    <dbReference type="EnsemblBacteria" id="ABB61178">
        <property type="protein sequence ID" value="ABB61178"/>
        <property type="gene ID" value="SDY_1013"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1013"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1181"/>
    <dbReference type="HOGENOM" id="CLU_073529_3_1_6"/>
    <dbReference type="OMA" id="ILDEKVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="150" mass="16714" checksum="908E25E8EF860B0A" modified="2005-12-06" version="1">MQQISFLPGEMTTALKALDRHIHEPGVAFTSTHAAREWLILNMAGLEREEFRVLYLNNQNQLIAGEPLFTGTINRTEVHPREVIKRALYHNAAAVVLAHNHPSGEVIPSKADRLITERLVQALGLVDIRVPDHLIVGSSQVFSFAEHGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HX7</accession>
    <name>Q32HX7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yejA</name>
        <name evidence="3" type="ordered locus">SDY_0902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HX7"/>
    <dbReference type="STRING" id="300267.SDY_0902"/>
    <dbReference type="EnsemblBacteria" id="ABB61078">
        <property type="protein sequence ID" value="ABB61078"/>
        <property type="gene ID" value="SDY_0902"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0902"/>
    <dbReference type="HOGENOM" id="CLU_023171_0_0_6"/>
    <dbReference type="OMA" id="VLPKHWW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221135" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="100"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="606" mass="69972" checksum="D64DA830B982594E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I38</accession>
    <name>Q32I38_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GSDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I38"/>
    <dbReference type="STRING" id="300267.SDY_0837"/>
    <dbReference type="EnsemblBacteria" id="ABB61019">
        <property type="protein sequence ID" value="ABB61019"/>
        <property type="gene ID" value="SDY_0837"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0837"/>
    <dbReference type="HOGENOM" id="CLU_201248_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8178" checksum="C64CE91AE59DC6A9" modified="2005-12-06" version="1">MVVSAIASTPQLFIGALKDKDVIVMSVNGDKVTEDGRILTDRGQRIRDVRTGPDGYLYVLTDESSGELLKVSPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I49</accession>
    <name>Q32I49_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybhK</name>
        <name evidence="3" type="ordered locus">SDY_0826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020190.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402497.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I49"/>
    <dbReference type="STRING" id="300267.SDY_0826"/>
    <dbReference type="EnsemblBacteria" id="ABB61008">
        <property type="protein sequence ID" value="ABB61008"/>
        <property type="gene ID" value="SDY_0826"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0826"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.952"/>
    <dbReference type="HOGENOM" id="CLU_044041_2_0_6"/>
    <dbReference type="OMA" id="LCGDDDW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="302" mass="32789" checksum="0F1F4A88F309BB38" modified="2005-12-06" version="1">MRNRTLADLERVVALGGGHGLGRVLSSLSSLGSRLTGIVTTTDNGGSTGRIRRSEGGIAWGDMRNCLNQLITEPSVASAMFEYRFGGNGELSGHNLGNLMLKALDHLSVRPLEAINLIRNLLKVDTHLIPMSEHPVDLMAIDDQGHEVYGEVNIDQLTTPIQELLLTPNIPATREAVHAINEADLIIIGPGSFYTSLMPILLLKEIAQALRRTPAPMVYIGNLGRELSLPAANLKLESKLAIMEQYVGKKVIDAVIVGPKVDVSAVKERIVIQEVLEASDIPYRHDRQLLHSALEKALQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IM2</accession>
    <name>Q32IM2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybgJ</name>
        <name evidence="5" type="ordered locus">SDY_0646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001188362.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402324.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IM2"/>
    <dbReference type="STRING" id="300267.SDY_0646"/>
    <dbReference type="EnsemblBacteria" id="ABB60835">
        <property type="protein sequence ID" value="ABB60835"/>
        <property type="gene ID" value="SDY_0646"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0646"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.754"/>
    <dbReference type="HOGENOM" id="CLU_020207_0_0_6"/>
    <dbReference type="OMA" id="QPGFAYM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00370">
        <property type="entry name" value="TIGR00370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="4"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="218" mass="23991" checksum="59821BF440CE4A5D" modified="2005-12-06" version="1">MQRARCYLIGETVVVLELEPPVTLASQKRIWRLAQRLVDMPNVVEAIPGMNNITVILRNPESLALDAIERLQRWWEESEALEPESRFIELPVVYGGAGGPDLAVVAAHCGLSEKQVVELHSSVEYVVWFLGFQPGFPYLGSLPEQLHTPRRAEPRLLVPAGSVGIGGPQTGVYPLATPGGWQLIGHTSLSLFDPARDEPILLRLGDSVRFVPQKEGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IR2</accession>
    <name>Q32IR2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-binding protein in pho regulon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybeZ</name>
        <name evidence="5" type="ordered locus">SDY_0596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402284.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IR2"/>
    <dbReference type="SMR" id="Q32IR2"/>
    <dbReference type="STRING" id="300267.SDY_0596"/>
    <dbReference type="EnsemblBacteria" id="ABB60795">
        <property type="protein sequence ID" value="ABB60795"/>
        <property type="gene ID" value="SDY_0596"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0596"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.700"/>
    <dbReference type="HOGENOM" id="CLU_051654_0_0_6"/>
    <dbReference type="OMA" id="NLCGQFD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="4">
        <location>
            <begin position="131"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="359" mass="40655" checksum="D37BA17D81FDA938" modified="2005-12-06" version="1">MFSFRRHTDKRNGLNIDTREITLEPADNARLLSLCGPFDDNIKQLERRLGIEINRRDNHFKLTGRPICVTAAADILRSLYVDTAPMRGQIQDIEPEQIHLAIKEARVLEQSAESVPEYGKAVNIKTKRGVIKPRTPNQAQYIANILDHDITFGVGPAGTGKTYLAVAAAVDALERQEIRRILLTRPAVEAGEKLGFLPGDLSQKVDPYLRPLYDALFEMLGFEKVEKLIERNVIEVAPLAYMRGRTLNDAFIILDESQNTTIEQMKMFLTRIGFNSKAVITGDVTQIDLPRNTKSGLRHAIEVLADVEEISFNFFHSEDVVRHPVVARIVNAYEAWEEAEQKRKAALAAERKREEQEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IT5</accession>
    <name>Q32IT5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybeQ</name>
        <name evidence="1" type="ordered locus">SDY_0568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402261.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IT5"/>
    <dbReference type="STRING" id="300267.SDY_0568"/>
    <dbReference type="EnsemblBacteria" id="ABB60772">
        <property type="protein sequence ID" value="ABB60772"/>
        <property type="gene ID" value="SDY_0568"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0568"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.671"/>
    <dbReference type="HOGENOM" id="CLU_000288_36_2_6"/>
    <dbReference type="OMA" id="YYRRGCH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="327" mass="37406" checksum="BEB2E2A988D89777" modified="2005-12-06" version="1">MIMIFTSSCCDNLSIDEIIERAEQGDSEAQYIVGFYYNRDSAIDSPDDEKAFYWLKLAAEQGHCEAQYSLGQKYTEDKSRHKDNEQAIFWLKKAALQGHTFASNALGWILDRGEDPNYKEAVAWYQIAAESGMSYAQNNLGWMYRNGNGVAQDYTLAFFWYKQAALQGHSDAQNNLADLYEDGKDVAQNETLAAFWYLKSAQQGNRHAQFQIAWDYNAGEGVDQDYKQAMYWYLKAAAQGSVGAYVNIGYMYKHGQGVEKDYQAAFEWFTKATECNDATAWYNLAIMYHYGEGRPVDLRQALDLYRKVQSSGTRDVSQEIRETEDLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IV5</accession>
    <name>CRCB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crcB</name>
        <name type="ordered locus">SDY_0547</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000939738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402241.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IV5"/>
    <dbReference type="SMR" id="Q32IV5"/>
    <dbReference type="STRING" id="300267.SDY_0547"/>
    <dbReference type="EnsemblBacteria" id="ABB60752">
        <property type="protein sequence ID" value="ABB60752"/>
        <property type="gene ID" value="SDY_0547"/>
    </dbReference>
    <dbReference type="GeneID" id="67416332"/>
    <dbReference type="KEGG" id="sdy:SDY_0547"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.647"/>
    <dbReference type="HOGENOM" id="CLU_114342_3_3_6"/>
    <dbReference type="OMA" id="FLMFESF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000252937" description="Putative fluoride ion transporter CrcB">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <sequence length="127" mass="13765" checksum="492499959425EFE7" modified="2005-12-06" version="1">MLQLLLAVFIGGGTGSVARWLLSMRFNPLHQAIPLGTLAANLIGAFIIGMGFAWFSRMTNIDPVWKVLITTGFCGGLTTFSTFSAEVVFLLQEGRFGWALLNVFVNLLGSFAMTALAFWLFSASTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IX1</accession>
    <name>Q32IX1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybdD</name>
        <name evidence="1" type="ordered locus">SDY_0530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000460431.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402225.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IX1"/>
    <dbReference type="STRING" id="300267.SDY_0530"/>
    <dbReference type="EnsemblBacteria" id="ABB60736">
        <property type="protein sequence ID" value="ABB60736"/>
        <property type="gene ID" value="SDY_0530"/>
    </dbReference>
    <dbReference type="GeneID" id="67416356"/>
    <dbReference type="KEGG" id="sdy:SDY_0530"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.624"/>
    <dbReference type="HOGENOM" id="CLU_171734_1_1_6"/>
    <dbReference type="OMA" id="GRIGRCC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007423">
        <property type="entry name" value="Sel_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38453">
        <property type="entry name" value="PTHR38453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04328">
        <property type="entry name" value="Sel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="65" mass="7467" checksum="F4A27656776F99AA" modified="2005-12-06" version="1">MFDSLAKAGKYLGQAAKLMIGMPDYDNYVEHMRVNHPDQTPMTYEEFFRERQDARYGGKGGARCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J31</accession>
    <name>Q32J31_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J31"/>
    <dbReference type="STRING" id="300267.SDY_0468"/>
    <dbReference type="EnsemblBacteria" id="ABB60676">
        <property type="protein sequence ID" value="ABB60676"/>
        <property type="gene ID" value="SDY_0468"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0468"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_11_6"/>
    <dbReference type="OMA" id="QQSTHRY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="116" mass="13187" checksum="AE4B2E12C6F62F49" modified="2005-12-06" version="1">MVTLCHVFGVHRSSYRYWKNRPEKPDGRRAVLRSQVLELHGISHGSAGARSIATMATRRGYQMGRWLAGRLMKELGLVSCQQSTHRYKRGGHEHVAIPNYLERQFAGDRAKSGVVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JH8</accession>
    <name>DXS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="1">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="1">DXP synthase</shortName>
            <shortName evidence="1">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dxs</name>
        <name type="ordered locus">SDY_0310</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="1">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000006826.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402018.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JH8"/>
    <dbReference type="SMR" id="Q32JH8"/>
    <dbReference type="STRING" id="300267.SDY_0310"/>
    <dbReference type="EnsemblBacteria" id="ABB60529">
        <property type="protein sequence ID" value="ABB60529"/>
        <property type="gene ID" value="SDY_0310"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0310"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.356"/>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_6"/>
    <dbReference type="OMA" id="QVGYHAQ"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000256484" description="1-deoxy-D-xylulose-5-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <sequence length="620" mass="67621" checksum="D29D10960BEEA7AA" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JP8</accession>
    <name>Q32JP8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">DNA polymerase III subunit epsilon</fullName>
            <ecNumber evidence="3 8">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">dnaQ</name>
        <name evidence="10" type="ordered locus">SDY_0234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001301976.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401948.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JP8"/>
    <dbReference type="STRING" id="300267.SDY_0234"/>
    <dbReference type="EnsemblBacteria" id="ABB60459">
        <property type="protein sequence ID" value="ABB60459"/>
        <property type="gene ID" value="SDY_0234"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0234"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.263"/>
    <dbReference type="HOGENOM" id="CLU_047806_2_0_6"/>
    <dbReference type="OMA" id="FHVYLNP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06131">
        <property type="entry name" value="DNA_pol_III_epsilon_Ecoli_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006309">
        <property type="entry name" value="DnaQ_proteo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01406">
        <property type="entry name" value="dnaQ_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="243" mass="27099" checksum="0350C9A0074227F8" modified="2005-12-06" version="1">MSTAITRQIVLDTETTGMNQIGAHYEGHKIIEIGAVEVVNRRLTGNNFHVYLKPDRLVDPEAFGVHGIADEFLLDKPTFAEVADEFMDYIRGAELVIHNAAFDIGFMDYEFSLLKRDIPKTNTFCKVTDSLAVARKMFPGKRNSLDALCARYEIDNSKRTLHGALLDAQILAEVYLAMTGGQTSMAFAMEGETQQQQGEATIQRLVRQASKLRVVFATDEELAAHEARLDLVQKKGGSCLWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JQ3</accession>
    <name>Q32JQ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative biotin synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yafE</name>
        <name evidence="2" type="ordered locus">SDY_0229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JQ3"/>
    <dbReference type="STRING" id="300267.SDY_0229"/>
    <dbReference type="EnsemblBacteria" id="ABB60454">
        <property type="protein sequence ID" value="ABB60454"/>
        <property type="gene ID" value="SDY_0229"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0229"/>
    <dbReference type="HOGENOM" id="CLU_037990_10_0_6"/>
    <dbReference type="OMA" id="FDFDWWC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="187" mass="21106" checksum="3BBE32B889CA9F97" modified="2005-12-06" version="1">MAYDLSAHMLDVVAQAAEARQLKNITTRHGYAESLPFADNAFDIVISRYSAHHWHDVGAALREVNRILKPGGRLIVMDVMSPGHPVRDIWLQTVEALRDTSHVRNYASCEWLTLINEANLIVDNLITDKLPLEFSSWVVRMRTPEALVDAIRIYQQSASTEVRTYFSLQNDGSFTSDIIMVEAHKAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JZ0</accession>
    <name>ZAPD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein ZapD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Z ring-associated protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">zapD</name>
        <name type="ordered locus">SDY_0132</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Localizes to mid-cell in an FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZapD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001194722.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401856.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JZ0"/>
    <dbReference type="SMR" id="Q32JZ0"/>
    <dbReference type="STRING" id="300267.SDY_0132"/>
    <dbReference type="EnsemblBacteria" id="ABB60367">
        <property type="protein sequence ID" value="ABB60367"/>
        <property type="gene ID" value="SDY_0132"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0132"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.150"/>
    <dbReference type="HOGENOM" id="CLU_076303_0_0_6"/>
    <dbReference type="OMA" id="LPAYYAW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01092">
        <property type="entry name" value="ZapD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009777">
        <property type="entry name" value="ZapD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027462">
        <property type="entry name" value="ZapD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036268">
        <property type="entry name" value="ZapD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39455">
        <property type="entry name" value="PTHR39455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07072">
        <property type="entry name" value="ZapD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160950">
        <property type="entry name" value="SSF160950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_1000064925" description="Cell division protein ZapD">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01092"/>
        </source>
    </evidence>
    <sequence length="247" mass="28264" checksum="5D72791B0011CA2C" modified="2005-12-06" version="1">MQTQVLFEHPLNEKMRTWLRIEFLIQQLTVNLPIADHAGALHFFRNVSELLDVFERGEVRTELLKELDRQQRKLQTWIGVPGVDQSRIEALIQQLKAAGSVLISAPRIGQFLREDRLIALVRQRLSIPGGCCSFDLPTLHIWLHLPQAQRDSQVETWIASLNPLTQALTMVLDLIRQSAPFRKQTSLNGFYQDNGGDADLLRLNLSLDSQLYPQISGHKSRFAIRFMPLDTENGQVPERLDFELACC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K11</accession>
    <name>MRAZ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraZ</name>
        <name type="ordered locus">SDY_0111</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378541.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401835.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K11"/>
    <dbReference type="SMR" id="Q32K11"/>
    <dbReference type="STRING" id="300267.SDY_0111"/>
    <dbReference type="EnsemblBacteria" id="ABB60346">
        <property type="protein sequence ID" value="ABB60346"/>
        <property type="gene ID" value="SDY_0111"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0111"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.130"/>
    <dbReference type="HOGENOM" id="CLU_107907_2_0_6"/>
    <dbReference type="OMA" id="RGQERCL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000230109" description="Transcriptional regulator MraZ">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 2" evidence="2">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <sequence length="152" mass="17370" checksum="4AD8AD9418EEF756" modified="2005-12-06" version="1">MFRGATLVNLDSKGRLSVPTRYREQLLENAAGQMVCTIDIHHPCLLLYPLPEWEIIEQKLPRLSSMNPVERRVQRLLLGHASECQMDGAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWHQQVKEDIDAEQLATGDLSERLQDLSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K22</accession>
    <name>LEUC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="1">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha-IPM isomerase</fullName>
            <shortName evidence="1">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuC</name>
        <name type="ordered locus">SDY_0099</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001140684.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401824.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K22"/>
    <dbReference type="SMR" id="Q32K22"/>
    <dbReference type="STRING" id="300267.SDY_0099"/>
    <dbReference type="EnsemblBacteria" id="ABB60335">
        <property type="protein sequence ID" value="ABB60335"/>
        <property type="gene ID" value="SDY_0099"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0099"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.118"/>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_6"/>
    <dbReference type="OMA" id="CNMSIEM"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000076807" description="3-isopropylmalate dehydratase large subunit">
        <location>
            <begin position="1"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <sequence length="466" mass="49938" checksum="337C84B3883F355B" modified="2005-12-06" version="1">MAKTLYEKLFDTHVVYEAENETPLLYIDRHLVHEVTSPQAFDGLRAHGRPVRQPGKTFATMDHNVSTQTKDINACGEMARIQMQELIKNCKEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYVKGRLHAPKGKDFDDAVAYWKTLQTDEGATFDTVVTLQAEEISPQVTWGTNPGQVISVNDNIPDPASFADPVERALAEKALAYMGLKPGIPLTEVAIDKVFIGSCTNSRIEDLRAAAEIAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGHFADIRNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K32</accession>
    <name>Q32K32_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">L-ribulose-5-phosphate 4-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Phosphoribulose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">araD</name>
        <name evidence="7" type="ordered locus">SDY_0088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:22368"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58226"/>
            <dbReference type="EC" id="5.1.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aldolase class II family. AraD/FucA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.4" evidence="3 5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000888654.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401814.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K32"/>
    <dbReference type="STRING" id="300267.SDY_0088"/>
    <dbReference type="EnsemblBacteria" id="ABB60325">
        <property type="protein sequence ID" value="ABB60325"/>
        <property type="gene ID" value="SDY_0088"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0088"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.103"/>
    <dbReference type="HOGENOM" id="CLU_006033_5_0_6"/>
    <dbReference type="OMA" id="PIFGTTH"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008742">
        <property type="term" value="F:L-ribulose-phosphate 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00989">
        <property type="entry name" value="AraD_entero"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004661">
        <property type="entry name" value="AraD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033748">
        <property type="entry name" value="AraD_entero"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00760">
        <property type="entry name" value="araD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aldolase_II" evidence="6">
        <location>
            <begin position="7"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="27"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="231" mass="25503" checksum="15C2DF9F90E05A1B" modified="2005-12-06" version="1">MLEDLKRQVLEANLALPKHNLVTLTWGNVSAVDRERGVFVIKPSGVDYSIMTADDMVVVSIETGEVVEGAKKPSSDTPTHRLLYQAFPSIGGIVHTHSRHATIWAQAGQSIPATGTTHADYFYGTIPCTRKMTDAEINGEYEWETGNVIVETFEKQGIDAAQMPGVLVHSHGPFAWGKNAEDAVHNAIVLEEVAYMGIFCRQLAPQLPDMQQTLLDKHYLRKHGAKAYYGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K50</accession>
    <name>KEFF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione-regulated potassium-efflux system ancillary protein KefF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Quinone oxidoreductase KefF</fullName>
            <ecNumber evidence="1">1.6.5.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kefF</name>
        <name type="ordered locus">SDY_0069</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + H(+) + NADH = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + H(+) + NADPH = a quinol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Interacts with KefC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000600719.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401796.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K50"/>
    <dbReference type="SMR" id="Q32K50"/>
    <dbReference type="STRING" id="300267.SDY_0069"/>
    <dbReference type="EnsemblBacteria" id="ABB60307">
        <property type="protein sequence ID" value="ABB60307"/>
        <property type="gene ID" value="SDY_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0069"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.79"/>
    <dbReference type="HOGENOM" id="CLU_058643_0_1_6"/>
    <dbReference type="OMA" id="YFAVHNT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008753">
        <property type="term" value="F:NADPH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032414">
        <property type="term" value="P:positive regulation of ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901381">
        <property type="term" value="P:positive regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01414">
        <property type="entry name" value="K_H_efflux_KefF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023948">
        <property type="entry name" value="K_H_efflux_KefF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47307:SF2">
        <property type="entry name" value="PTHR47307:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000068471" description="Glutathione-regulated potassium-efflux system ancillary protein KefF">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="65"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01414"/>
        </source>
    </evidence>
    <sequence length="176" mass="20125" checksum="A991AD5AA0CAB770" modified="2005-12-06" version="1">MILIIYAHPYPHHSHANKRMLEQARTLDGVEIRSLYQLYPDFNIDIAAEQEALSRADLIVWQHPMQWYSIPPLLKLWIDKVLSHGWAYGHGGTAPRGKHLLWAVTTGGGESHFEIGAHPGFDVLSQPLQATAIYCGLNWLPPFAMHCTFICDDETLEGQARHYKQRLLEWQEAHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q326N1</accession>
    <name>Q326N1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IcsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">icsA</name>
        <name evidence="5" type="ordered locus">SDY_P214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Sd197</strain>
            <plasmid evidence="6">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001071790.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406215.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326N1"/>
    <dbReference type="EnsemblBacteria" id="ABB64727">
        <property type="protein sequence ID" value="ABB64727"/>
        <property type="gene ID" value="SDY_P214"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P214"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5768"/>
    <dbReference type="HOGENOM" id="CLU_002551_8_0_6"/>
    <dbReference type="OMA" id="DAWLQYG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01344">
        <property type="entry name" value="PL2_Passenger_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043990">
        <property type="entry name" value="AC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005546">
        <property type="entry name" value="Autotransporte_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036709">
        <property type="entry name" value="Autotransporte_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013425">
        <property type="entry name" value="Autotrns_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006315">
        <property type="entry name" value="OM_autotransptr_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18883">
        <property type="entry name" value="AC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03797">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12951">
        <property type="entry name" value="PATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00869">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103515">
        <property type="entry name" value="SSF103515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01414">
        <property type="entry name" value="autotrans_barl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02601">
        <property type="entry name" value="autotrns_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51208">
        <property type="entry name" value="AUTOTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Autotransporter" evidence="4">
        <location>
            <begin position="814"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1102" mass="116336" checksum="CA2AFFB1FDD9EA5E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q326R7</accession>
    <name>Q326R7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MxiK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mxiK</name>
        <name evidence="1" type="ordered locus">SDY_P178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406179.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326R7"/>
    <dbReference type="EnsemblBacteria" id="ABB64691">
        <property type="protein sequence ID" value="ABB64691"/>
        <property type="gene ID" value="SDY_P178"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P178"/>
    <dbReference type="HOGENOM" id="CLU_1554232_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013388">
        <property type="entry name" value="T3SS_OrgA/MxiK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09482">
        <property type="entry name" value="OrgA_MxiK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02555">
        <property type="entry name" value="OrgA_MxiK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="172" mass="19655" checksum="BD374A7746B90770" modified="2005-12-06" version="1">MDGIYKKYLSIIFDPAFYINRNRLNLPSELLENGVIRSEINNLIINKYDLNCDIDPLSGVTAMFVANWNLLPAVAYFIGSQESRLINHSEMVISYYGGKISKQGEAAIRSGFWHLIAWKENISVGVYERINLLFNPIVLEGNYTPVERNLSRLNEGMQYAKRHFTGIQTSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q326W5</accession>
    <name>Q326W5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406131.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326W5"/>
    <dbReference type="EnsemblBacteria" id="ABB64643">
        <property type="protein sequence ID" value="ABB64643"/>
        <property type="gene ID" value="SDY_P130"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P130"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5685"/>
    <dbReference type="HOGENOM" id="CLU_046484_14_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002071">
        <property type="entry name" value="Thermonucl_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01284">
        <property type="entry name" value="TNASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="76" mass="8787" checksum="E5593A43AE48B9EB" modified="2005-12-06" version="1">MMKSLVAGKTVTVTYFQRDRYGRILGQVYAPDGMNINQFMVRAGAAWVYEQYNTDPVLPVLQNEARQQKRGLWSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q327H6</accession>
    <name>Q327H6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative IS orf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406020.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327H6"/>
    <dbReference type="EnsemblBacteria" id="ABB64532">
        <property type="protein sequence ID" value="ABB64532"/>
        <property type="gene ID" value="SDY_P019"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P019"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5554"/>
    <dbReference type="HOGENOM" id="CLU_113764_2_0_6"/>
    <dbReference type="OMA" id="PNFTEAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="135" mass="14963" checksum="305F314BEF427608" modified="2005-12-06" version="1">MPKLPVVKKRPRRPNFPYEFKIALVEQSLQPGACVAQIARENGINDNLLFNWRHQYRKGGLLPSGKNMPALLPVTLTPEPDNKIPAPAQEPEQINTPSDSLCCELVLPAGTLRLKGKLTPALLQILIREIKGSSH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q327I2</accession>
    <name>OSPF_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Phosphothreonine lyase OspF</fullName>
            <ecNumber>4.2.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Effector protein OspF</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ospF</name>
        <name type="synonym">mkaD</name>
        <name type="ordered locus">SDY_P013</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid">
        <name>pSD1_197</name>
    </geneLocation>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14 in an irreversible reaction, thus preventing the downstream phosphorylation of histone H3. This epigenetic modification results in inhibition of the transcription of a specific subset of pro-inflammatory genes, and ultimately to a reduced immune response against the invading pathogen. The diminished immune response enhances the bacterium's ability to disseminate and multiply within the host.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
        <text evidence="1">Secreted via the type III secretion system (TTSS). Localizes in the nucleus of the infected cell (By similarity).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphothreonine lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-"/>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001121864.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406014.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327I2"/>
    <dbReference type="SMR" id="Q327I2"/>
    <dbReference type="EnsemblBacteria" id="ABB64526">
        <property type="protein sequence ID" value="ABB64526"/>
        <property type="gene ID" value="SDY_P013"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P013"/>
    <dbReference type="HOGENOM" id="CLU_100525_0_0_6"/>
    <dbReference type="OMA" id="RVDQQSR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003519">
        <property type="entry name" value="OspF/SpvC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038498">
        <property type="entry name" value="OspF/SpvC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03536">
        <property type="entry name" value="VRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01342">
        <property type="entry name" value="SALVRPPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0614">Plasmid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000299352" description="Phosphothreonine lyase OspF">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="239" mass="27900" checksum="95A9F09DD94D1A3B" modified="2005-12-06" version="1">MPIKKPCLKLNLDSLNVVRSEIPQMLSANERLKNNFNILYNQIRQYPAYYFKVASNVPNYSDICQFFSVMYQGFQIVNHSGDVFIHACRENPQSKGDFVGDKFHISIAREQVPLAFQILSGLLFSEDSPIDKWKITDMNRVSQQSRVGIGAQFTLYVKSDQECSQYSALLLHKIRQFIMCLESNLLRSKIAPGEYPASDVRPEDWKYVSYRNELRSDRNGSERQEQMLREEPFYRLMIE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q327K2</accession>
    <name>TRPR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trp operon repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpR</name>
        <name type="ordered locus">SDY_4654</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000068679.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405994.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327K2"/>
    <dbReference type="SMR" id="Q327K2"/>
    <dbReference type="STRING" id="300267.SDY_4654"/>
    <dbReference type="EnsemblBacteria" id="ABB64503">
        <property type="protein sequence ID" value="ABB64503"/>
        <property type="gene ID" value="SDY_4654"/>
    </dbReference>
    <dbReference type="GeneID" id="66671719"/>
    <dbReference type="KEGG" id="sdy:SDY_4654"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5516"/>
    <dbReference type="HOGENOM" id="CLU_147939_0_0_6"/>
    <dbReference type="OMA" id="GQMSQRE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00475">
        <property type="entry name" value="Trp_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000831">
        <property type="entry name" value="Trp_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013335">
        <property type="entry name" value="Trp_repress_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038116">
        <property type="entry name" value="TrpR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38025">
        <property type="entry name" value="PTHR38025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01371">
        <property type="entry name" value="Trp_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003196">
        <property type="entry name" value="Trp_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01321">
        <property type="entry name" value="TrpR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000014049" description="Trp operon repressor">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00475"/>
        </source>
    </evidence>
    <sequence length="108" mass="12355" checksum="FDFF8A60EC4FE7BE" modified="2005-12-06" version="1">MAQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q327S5</accession>
    <name>Q327S5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-binding component of dipeptide transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dppD</name>
        <name evidence="6" type="ordered locus">SDY_4564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001196499.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405921.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327S5"/>
    <dbReference type="STRING" id="300267.SDY_4564"/>
    <dbReference type="EnsemblBacteria" id="ABB64430">
        <property type="protein sequence ID" value="ABB64430"/>
        <property type="gene ID" value="SDY_4564"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4564"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5402"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_6"/>
    <dbReference type="OMA" id="GSMPRID"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="327" mass="35933" checksum="82ED9294B44C910A" modified="2005-12-06" version="1">MALLNVDKLSVHFGDESAPFRAVDRISYSVKQGEVVGIVGESGSGKSVSSLAIMGLIDYPGRVMAEKLVFNSQDLQRISEKERRNLVGAEVAMIFQDPMTSLNPCYTVGFQIMEAIKVHQGGNKSTRRQRAIDLLNQVGIPDPASRLDVYPHQLSGGMSQRVMIAMAIACRPKLLIADEPTTALDVTIQAQIIELLLELQQKENMALVLITHDLALVAEAVHKIIVMYAGQVVETGDAHAIFHAPRHPYTQALLRALPEFAQDKERLASLPGVVPGKYDRPNGCLLNPRCPYATDRCRAEEPALNMLADGRQFKCHYPLDDAGRPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q328D9</accession>
    <name>Q328D9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yjeP</name>
        <name evidence="13" type="ordered locus">SDY_4433</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001236783.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405807.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328D9"/>
    <dbReference type="STRING" id="300267.SDY_4433"/>
    <dbReference type="EnsemblBacteria" id="ABB64316">
        <property type="protein sequence ID" value="ABB64316"/>
        <property type="gene ID" value="SDY_4433"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4433"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5231"/>
    <dbReference type="HOGENOM" id="CLU_007829_2_0_6"/>
    <dbReference type="OMA" id="MALITFD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006686">
        <property type="entry name" value="MscS_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025692">
        <property type="entry name" value="MscS_IM_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024393">
        <property type="entry name" value="MscS_porin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12795">
        <property type="entry name" value="MscS_porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12794">
        <property type="entry name" value="MscS_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01246">
        <property type="entry name" value="UPF0003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220944" evidence="10">
        <location>
            <begin position="20"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="828"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="879"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="903"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="MscS_porin" evidence="12">
        <location>
            <begin position="31"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="MscS_TM" evidence="11">
        <location>
            <begin position="478"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB64316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1107" mass="123879" checksum="3B56CB3115FDD54E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q328G8</accession>
    <name>Q328G8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_3711</name>
        <name evidence="5" type="ordered locus">SDY_4400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63671">
        <property type="protein sequence ID" value="ABB63671"/>
        <property type="gene ID" value="SDY_3711"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64287">
        <property type="protein sequence ID" value="ABB64287"/>
        <property type="gene ID" value="SDY_4400"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3711"/>
    <dbReference type="KEGG" id="sdy:SDY_4400"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="118" mass="13389" checksum="429A3932DA8E2175" modified="2005-12-06" version="1">MAVKPGNTGSGTRITPKQGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q328H0</accession>
    <name>Q328H0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Fumarate reductase flavoprotein subunit</fullName>
            <ecNumber evidence="6 16">1.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">frdA</name>
        <name evidence="20" type="ordered locus">SDY_4398</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a menaquinone + succinate = a menaquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:27834"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="6 16"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001192973.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405776.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
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            <begin position="453"/>
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        <location>
            <begin position="581"/>
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        </location>
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            <begin position="583"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABB64285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="602" mass="65972" checksum="3306D7FF6E198AE9" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q328L1</accession>
    <name>Q328L1_SHIDS</name>
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        <submittedName>
            <fullName evidence="8">Putative resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yhjX</name>
        <name evidence="8" type="ordered locus">SDY_4355</name>
    </gene>
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        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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        <location>
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            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="347" mass="37039" checksum="36D5721E6E8550FC" modified="2005-12-06" version="1">MLSLGLAISSSVAGKLQERFGVKRVTIASGILLGLGFFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALVMIVFGATLMKDAPKQEVKTSNGVVEKDYTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFSLNNLAKNYGMIYLGFGIGIICGSIIASLFGGFYVTFYVIFALLILSLALSTTIRQPEQKVLREAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Q4</accession>
    <name>Q328Q4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISSfl4 ORF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Q4"/>
    <dbReference type="STRING" id="300267.SDY_4305"/>
    <dbReference type="EnsemblBacteria" id="ABB64201">
        <property type="protein sequence ID" value="ABB64201"/>
        <property type="gene ID" value="SDY_4305"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4305"/>
    <dbReference type="HOGENOM" id="CLU_023034_5_5_6"/>
    <dbReference type="OMA" id="SIEPEAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039552">
        <property type="entry name" value="IS66_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13817">
        <property type="entry name" value="DDE_Tnp_IS66_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66_C" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8483" checksum="CF5CD251ADB9D1DB" modified="2005-12-06" version="1">MKSLESWLREKMKTLFFGSGHGGERGALLYSLIGTCKLNDVDPESYLRHVLGVIADWPVNRISELLPWRIALPAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q328S3</accession>
    <name>SYV_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Valyl-tRNA synthetase</fullName>
            <shortName evidence="1">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">valS</name>
        <name type="ordered locus">SDY_4282</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000416361.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405673.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328S3"/>
    <dbReference type="SMR" id="Q328S3"/>
    <dbReference type="STRING" id="300267.SDY_4282"/>
    <dbReference type="EnsemblBacteria" id="ABB64182">
        <property type="protein sequence ID" value="ABB64182"/>
        <property type="gene ID" value="SDY_4282"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4282"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5048"/>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_6"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000224555" description="Valine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="880"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="554"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <sequence length="951" mass="108136" checksum="AC5EC892E14A62A3" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q328T0</accession>
    <name>Q328T0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS2 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_4274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405666.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328T0"/>
    <dbReference type="EnsemblBacteria" id="ABB64175">
        <property type="protein sequence ID" value="ABB64175"/>
        <property type="gene ID" value="SDY_4274"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4274"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5036"/>
    <dbReference type="HOGENOM" id="CLU_027402_25_0_6"/>
    <dbReference type="OMA" id="ADICMEH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="121" mass="13422" checksum="43E9BF4D452E067A" modified="2005-12-06" version="1">MIDVLGPEKRRRRTAQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQIKELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Y2</accession>
    <name>Q328Y2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjbF</name>
        <name evidence="2" type="ordered locus">SDY_4221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405614.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Y2"/>
    <dbReference type="STRING" id="300267.SDY_4221"/>
    <dbReference type="EnsemblBacteria" id="ABB64123">
        <property type="protein sequence ID" value="ABB64123"/>
        <property type="gene ID" value="SDY_4221"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4221"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4970"/>
    <dbReference type="HOGENOM" id="CLU_098990_1_0_6"/>
    <dbReference type="OMA" id="TTKGLGN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021308">
        <property type="entry name" value="GfcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023373">
        <property type="entry name" value="YmcC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11102">
        <property type="entry name" value="YjbF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF159270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220576" evidence="1">
        <location>
            <begin position="31"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="222" mass="24951" checksum="A511854B54DA0579" modified="2005-12-06" version="1">MVILPLWRRVVKRPALILICLLLQACSATTKELGNSLWDSLFGTPGVQLTDDDIQNMPYASQYMQFNGGPQLFVVLAFAEDGQQKWVTQDQATLVTQHGRLVKTLLGGDNLIEVNNLAADPLIKPAQIVDGATWTRTMGWTEYQQVRYATARSVFKWDGTGTVKVGSDETAVRVLDEEVSTDQARWHNRYWIDSEGQIRQSEQYLGADYFPVKTTLIKAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q329D9</accession>
    <name>Q329D9_SHIDS</name>
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        <submittedName>
            <fullName evidence="8">2-module integral membrane pump</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">emrD</name>
        <name evidence="8" type="ordered locus">SDY_4157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405557.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329D9"/>
    <dbReference type="STRING" id="300267.SDY_4157"/>
    <dbReference type="EnsemblBacteria" id="ABB64066">
        <property type="protein sequence ID" value="ABB64066"/>
        <property type="gene ID" value="SDY_4157"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4157"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4886"/>
    <dbReference type="HOGENOM" id="CLU_001265_47_1_6"/>
    <dbReference type="OMA" id="YYVIVTM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004734">
        <property type="entry name" value="Multidrug-R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="11"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="396" mass="42421" checksum="6A0CDDE8BB775ACF" modified="2005-12-06" version="1">MIMKRHRNVNLLLILVLLVAVGQMAQTIYIPAIADMARDLNVREGAVQSVMGAYLLTYGVSQLFYGPISDRVGRRPVILVGMSIFMLATLVAVTTSSLTVLIAASAMQGMGTGVGGVMARTLPRDLYERTQLRHANSLLNMGILVSPLLAPLIGGLLDTMWNWRACYLFLLVLCAGVTFSMARWMPETRPVDAPRTRLLTSYKTLFGNGGFNCYLLMLIGGLAGIAAFEACSGVLMGAVLGLSSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLLMWIPDWFGVMNVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNIGSGVLASLSAMLPQTGQGSLGLLMTLMGLLIVLCWLPLATRMSHQGQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q329H5</accession>
    <name>Q329H5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding component of phosphonate transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">phnL</name>
        <name evidence="5" type="ordered locus">SDY_4120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000611426.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405521.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329H5"/>
    <dbReference type="STRING" id="300267.SDY_4120"/>
    <dbReference type="EnsemblBacteria" id="ABB64030">
        <property type="protein sequence ID" value="ABB64030"/>
        <property type="gene ID" value="SDY_4120"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4120"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4844"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="MHLRDGI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012701">
        <property type="entry name" value="CP_lyase_PhnL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02324">
        <property type="entry name" value="CP_lyasePhnL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="226" mass="24689" checksum="0F3CCFC6838B77E4" modified="2005-12-06" version="1">MINVQNVSKTFILHQQNGVRLPVLQRASLTVNAGECVVLHGHSGSGKSTLLRSLYANYLPDEGQIQIKHGDEWVDLVTAPARKVVEIRKTTVGWVSQFLRVIPRISALEVVMQPLLDTGVPREACAAKAARLLTRLNVPERLWHLAPSTFSGGEQQRVNIARGFIVDYPILLLDEPTASLDAKNSAAVVELIREAKARGAAIVGIFHDEAVRNDVADRLHPMGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q329P1</accession>
    <name>Q329P1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yibP</name>
        <name evidence="4" type="ordered locus">SDY_4046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378924.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405455.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329P1"/>
    <dbReference type="STRING" id="300267.SDY_4046"/>
    <dbReference type="MEROPS" id="M23.950"/>
    <dbReference type="EnsemblBacteria" id="ABB63964">
        <property type="protein sequence ID" value="ABB63964"/>
        <property type="gene ID" value="SDY_4046"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4046"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4762"/>
    <dbReference type="HOGENOM" id="CLU_029425_4_0_6"/>
    <dbReference type="OMA" id="SDPAQWC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="328"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="427" mass="47423" checksum="443C41CEC97A572B" modified="2005-12-06" version="1">MRGKAINTMTRAVKPRRFAIMPIIYASVLSAGVLLCAFSAHADERDQLKSIQADIAAKERAVRQKQQQRASLLAQLKKQEEAISEATRKLRETQNTLNQLNKQIDEMNASIAKLEQQKAAQERSLAAQLDAAFRQGEHTGIQLILSGEESQRGQRLQAYFGYLNQARQETIAQLKQTREEVAMQRAELEEKQSEQQTLLYEQRAQQAKLTQALNERKKTLAGLESSIQQGQQQLSELRANESRLRNSIARAEAAAKARAEREAREAQAVRDRQKEATRKGTTYKPTESEKSLMSRTGGLGAPRGQAFWPVRGPTLHRYGEQLQGELRWKGMVIGASEGTEVKAIADGRVILADWLQGYGLVVVVEHGKGDMSLYGYNQSALVSVGSQVRAGQPIALVGSSGGQGRPSLYFEIRHQGQAVNPQPWLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q329T1</accession>
    <name>Q329T1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Initiation of chromosome replication</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mioC</name>
        <name evidence="5" type="ordered locus">SDY_4006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000763741.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405415.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329T1"/>
    <dbReference type="STRING" id="300267.SDY_4006"/>
    <dbReference type="EnsemblBacteria" id="ABB63924">
        <property type="protein sequence ID" value="ABB63924"/>
        <property type="gene ID" value="SDY_4006"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4006"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4718"/>
    <dbReference type="HOGENOM" id="CLU_051402_4_1_6"/>
    <dbReference type="OMA" id="ACFGSGD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="147" mass="15782" checksum="E42A4BD748DE85CF" modified="2005-12-06" version="1">MADITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGPLLEDLSASGIWLVISSTHGAGDIPDNLSPFYEALQEQKPDLSAVRFGAIGIGSREYDTFCGAIDKLEAELKNSGAKQTGEALKINILDHDIPEDPAEEWLGSWINLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Y6</accession>
    <name>Q329Y6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yigA</name>
        <name evidence="1" type="ordered locus">SDY_3935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000811356.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405360.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Y6"/>
    <dbReference type="STRING" id="300267.SDY_3935"/>
    <dbReference type="EnsemblBacteria" id="ABB63869">
        <property type="protein sequence ID" value="ABB63869"/>
        <property type="gene ID" value="SDY_3935"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3935"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4646"/>
    <dbReference type="HOGENOM" id="CLU_073320_0_0_6"/>
    <dbReference type="OMA" id="FQVPFVS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007435">
        <property type="entry name" value="DUF484"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38765">
        <property type="entry name" value="PTHR38765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04340">
        <property type="entry name" value="DUF484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="235" mass="26729" checksum="35B06C47911E4CF5" modified="2005-12-06" version="1">MKQLGEELQETLTELDDRAVVDYLIKNPEFFIRNARAVEAIRVPHPVRGTVSLVEWHMARARNHIHVLEENMALLMEQAIANEGLFYRLLYLQRSLTAASSLDDMLMRFYRWARDLGLAGASLRLFPDRWRLGAPSNHTHLALSRQSFEPLRIQRLGQGQHYLGPLNGPELLVVLPEAKAVGSVAMSMLGSDADLGVVLFTSRDASHYQQGQGMQLLHEIALMLPELLERWIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Y8</accession>
    <name>Q329Y8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yigB</name>
        <name evidence="2" type="ordered locus">SDY_3933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001213588.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405358.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Y8"/>
    <dbReference type="STRING" id="300267.SDY_3933"/>
    <dbReference type="EnsemblBacteria" id="ABB63867">
        <property type="protein sequence ID" value="ABB63867"/>
        <property type="gene ID" value="SDY_3933"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3933"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4644"/>
    <dbReference type="HOGENOM" id="CLU_045011_8_2_6"/>
    <dbReference type="OMA" id="PQETHDT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="238" mass="27112" checksum="9C190E70D642E0D6" modified="2005-12-06" version="1">MRFYRPLGRISALTFDLDDTLYDNRPVILRTEREALTFVQNYHPALRSFQNEDLQRLRQAVREAEPEIYHDVTRWRFRSIEQAMLDAGLSAEEASAGAHAAMINFAKWRSRIDVSQQTHDTLKQLAKKWPLVAITNGNAQPELFGLGDYFEFVLRAGPHGRSKPFSDMYFLAAEKLNVPIGEILHVGDDLTTDVGGAIRSGMQACWIRPENGDLMQTWDSRLLPHLEISRLASLTSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A74</accession>
    <name>Q32A74_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">2-keto-3-deoxygluconate permease</fullName>
            <shortName evidence="10">KDG permease</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">kdgT</name>
        <name evidence="11" type="ordered locus">SDY_3837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the KdgT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A74"/>
    <dbReference type="STRING" id="300267.SDY_3837"/>
    <dbReference type="EnsemblBacteria" id="ABB63781">
        <property type="protein sequence ID" value="ABB63781"/>
        <property type="gene ID" value="SDY_3837"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3837"/>
    <dbReference type="HOGENOM" id="CLU_057476_0_1_6"/>
    <dbReference type="OMA" id="ESGPFMT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015649">
        <property type="term" value="F:2-keto-3-deoxygluconate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00070">
        <property type="entry name" value="KdgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004684">
        <property type="entry name" value="2keto-3dGluconate_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018395">
        <property type="entry name" value="2keto-3dGluconate_permease_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03812">
        <property type="entry name" value="KdgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00793">
        <property type="entry name" value="kdgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="331" mass="34132" checksum="0C8ADBD2B55698BD" modified="2005-12-06" version="1">MMEMQIKRSIEKIPGGMMLVPLFLGALCHTFSPGAGKYFGSFTNGMITGTVPILAVWFFCMGASIKLSATGTVLRKSGTLAVTKIAVAWVVAAIASRIIPEHGVEVGGFFAGLSTLALVAAMDMTNGGLYASIMQQYGTKEEAGAFVLMSLESGPLMTMIILGTAGIVSFEPHVFVGAVLPFLVGFALGNLDPELREFFSKAVQTLIPFFAFALGNTIDLTVIAQTGLLGILLGVAVIIVTGIPLIIADKLIGGGDGTAGIAASSSAGAAVATPVLIAEMVPAFKPMAPAATSLVATAVIVTSILVPILTSIWSRKIKARAAKIEILGTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A75</accession>
    <name>Q32A75_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yiiM</name>
        <name evidence="2" type="ordered locus">SDY_3836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A75"/>
    <dbReference type="STRING" id="300267.SDY_3836"/>
    <dbReference type="EnsemblBacteria" id="ABB63780">
        <property type="protein sequence ID" value="ABB63780"/>
        <property type="gene ID" value="SDY_3836"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3836"/>
    <dbReference type="HOGENOM" id="CLU_082566_1_1_6"/>
    <dbReference type="OMA" id="CWKLNDR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005163">
        <property type="entry name" value="YiiM-like_3-alpha_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03475">
        <property type="entry name" value="3-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="36"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="234" mass="26620" checksum="21A15278C5B81ACA" modified="2005-12-06" version="1">MGKFLVEREQMRYPVDVYTGKIQAYPEGKPSAIAKIQVDGELMLTELGLEGDEQAEKKVHGGPDRALCHYPREHYLYWAREFREQAELFVAPAFGENLSTDGLTESNVYMGDIFRWGEALIQVSQPRSPCYKLNYHFDISDIAQLMQNTGKVGWLYSVIAPGKVSADAPLELVSRVSDVTVQEAAAIAWHMPFDDDQYHRLLSAAGLSKSWTRTMQKRRLSGKIEDFSRRLWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A89</accession>
    <name>Q32A89_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yiiT</name>
        <name evidence="4" type="ordered locus">SDY_3821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for resistance to DNA-damaging agents.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000323555.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405257.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A89"/>
    <dbReference type="SMR" id="Q32A89"/>
    <dbReference type="STRING" id="300267.SDY_3821"/>
    <dbReference type="EnsemblBacteria" id="ABB63766">
        <property type="protein sequence ID" value="ABB63766"/>
        <property type="gene ID" value="SDY_3821"/>
    </dbReference>
    <dbReference type="GeneID" id="58459836"/>
    <dbReference type="KEGG" id="sdy:SDY_3821"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4512"/>
    <dbReference type="HOGENOM" id="CLU_049301_18_0_6"/>
    <dbReference type="OMA" id="RRMINKM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="142" mass="16275" checksum="0684CAA0EAA4CF6C" modified="2005-12-06" version="1">MAYKHIGVAISGNEEDALLVNKALELARHNDAHLTLIHIDDGLSELYPGIYFPATEDILQLLKNKSDNKLYKLTKNIQWPKTKLRIERGEMPETLLEIMQKEQCDLLVCGHHHSFINRLMPAYRGMINKLSADLLIVPFIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AA0</accession>
    <name>Q32AA0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405246.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AA0"/>
    <dbReference type="EnsemblBacteria" id="ABB63755">
        <property type="protein sequence ID" value="ABB63755"/>
        <property type="gene ID" value="SDY_3810"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3810"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4501"/>
    <dbReference type="HOGENOM" id="CLU_2540731_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9388" checksum="EB9C04F50EB0C11A" modified="2005-12-06" version="1">MHSIEELTAIQNGTAEMHVCDVQGFACAYQEGVQTMSDGKVRHAIFMTLLDNTNLIQLVAAIDPDYFDEYQEEVMKMMLSARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AE4</accession>
    <name>Q32AE4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yijD</name>
        <name evidence="2" type="ordered locus">SDY_3764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000806416.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405202.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AE4"/>
    <dbReference type="STRING" id="300267.SDY_3764"/>
    <dbReference type="EnsemblBacteria" id="ABB63711">
        <property type="protein sequence ID" value="ABB63711"/>
        <property type="gene ID" value="SDY_3764"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3764"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4451"/>
    <dbReference type="HOGENOM" id="CLU_138008_1_0_6"/>
    <dbReference type="OMA" id="GSNFFAI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009867">
        <property type="entry name" value="DUF1422"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07226">
        <property type="entry name" value="DUF1422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13042" checksum="427AC26C9BA21B6A" modified="2005-12-06" version="1">MKQANQDRGTMLLALVAGLSINGTFAALFSSIVPFSVFPIISLVLTVYCLHQRYLNRTMPVGLPGLAAACFILGVLLYSTVVRAEYPDIGSNFFPAVLSVIMVFWIGAKMRNRKQEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AS8</accession>
    <name>Q32AS8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High-affinity branched-chain amino acid transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">livH</name>
        <name evidence="8" type="ordered locus">SDY_3606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000003016.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405068.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AS8"/>
    <dbReference type="STRING" id="300267.SDY_3606"/>
    <dbReference type="EnsemblBacteria" id="ABB63577">
        <property type="protein sequence ID" value="ABB63577"/>
        <property type="gene ID" value="SDY_3606"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3606"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4282"/>
    <dbReference type="HOGENOM" id="CLU_039929_3_1_6"/>
    <dbReference type="OMA" id="NMGWFLI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="282" mass="30298" checksum="263CC400259826BB" modified="2005-12-06" version="1">MSEQFLYFLQQMFNGVTLGSTYTLIAIGYTMVYGIIGMINFAHGEVYMIGSYVSFMIIAALMMMGIDTGWLLVAAGFVGAIVIASAYGWSIERVAYRPVRNSKRLIALISAIGMSIFLQNYVSLTEGSRDVALPSLFNGQWVVGHSENFSASITTMQAVIWIVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGMKAFTAAVLGGIGSIPGAMIVGLILVLLVMPTGILGRPEVEKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B79</accession>
    <name>PRMA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="1">L11 Mtase</shortName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prmA</name>
        <name type="ordered locus">SDY_3436</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001145827.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404917.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B79"/>
    <dbReference type="SMR" id="Q32B79"/>
    <dbReference type="STRING" id="300267.SDY_3436"/>
    <dbReference type="EnsemblBacteria" id="ABB63426">
        <property type="protein sequence ID" value="ABB63426"/>
        <property type="gene ID" value="SDY_3436"/>
    </dbReference>
    <dbReference type="GeneID" id="66672847"/>
    <dbReference type="KEGG" id="sdy:SDY_3436"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4092"/>
    <dbReference type="HOGENOM" id="CLU_049382_4_1_6"/>
    <dbReference type="OMA" id="EFFFIFP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00406">
        <property type="entry name" value="prmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000046095" description="Ribosomal protein L11 methyltransferase">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <sequence length="293" mass="31877" checksum="CF0EDE130245B8FC" modified="2005-12-06" version="1">MPWIQLKLNTTGANAEDLSDALMEAGAVSITFQDTHDTPVFEPLPGETRLWGDTDVIGLFDAETDMNDVVAILENHPLLGAGFAHKIEQLEDKDWEREWMDNFHPMRFGERLWICPSWRDVPDENAVNVMLDPGLAFGTGTHPTTSLCLQWLDSLDLTGKTVIDFGCGSGILAIAALKLGAAKAIGIDIDPQAIQASRDNAERNGVSDRLELYLPKDQPEEMKADVVVANILAGPLRELAPLISVLPVSGGLLGLSGILASQAESVCEAYADSFALDPVVEKEEWCRITGRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BV7</accession>
    <name>Q32BV7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Tyrosine recombinase XerD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">xerD</name>
        <name evidence="16" type="ordered locus">SDY_3188</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerD specifically exchanges the bottom DNA strands.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">FtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000806638.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404689.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BV7"/>
    <dbReference type="SMR" id="Q32BV7"/>
    <dbReference type="STRING" id="300267.SDY_3188"/>
    <dbReference type="EnsemblBacteria" id="ABB63198">
        <property type="protein sequence ID" value="ABB63198"/>
        <property type="gene ID" value="SDY_3188"/>
    </dbReference>
    <dbReference type="GeneID" id="66673232"/>
    <dbReference type="KEGG" id="sdy:SDY_3188"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3810"/>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_6"/>
    <dbReference type="OMA" id="QAFWYLI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01807">
        <property type="entry name" value="Recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="15">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="14">
        <location>
            <begin position="108"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB63198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="298" mass="34246" checksum="B75DD603BEEE03E9" modified="2005-12-06" version="1">MKQDLARIEQFLDALWLEKNLAENTLNAYRRDLSMMVEWLHHRGLTLATAQSDDLQALLAERLEGGYKATSSARLLSAVRRLFQYLYREKFREDDPSAHLASPKLPQRLPKDLSEAQVERLLQAPLIDQPLELRDKAMLEVLYATGLRVSELVGLTMSDISLRQGVVRVIGKGNKERLVPLGEEAVYWLETYLEHGRPWLLNGVSIDVLFPSQRAQQMTRQTFWHRIKHYAVLAGIDSEKLSPHVLRHAFATHLLNHGADLRVVQMLLGHSDLSTTQIYTHVATERLRQLHQQHHPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C03</accession>
    <name>Q32C03_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404643.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C03"/>
    <dbReference type="STRING" id="300267.SDY_3138"/>
    <dbReference type="EnsemblBacteria" id="ABB63152">
        <property type="protein sequence ID" value="ABB63152"/>
        <property type="gene ID" value="SDY_3138"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3138"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3747"/>
    <dbReference type="HOGENOM" id="CLU_163404_0_0_6"/>
    <dbReference type="OMA" id="QNTLPPC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="124" mass="13309" checksum="711BD3E55E0CCFA2" modified="2005-12-06" version="1">MNYQLYVRNYSRNTNYEIVATVDGLDVLNGKQGSLNNNGYIVNAGDSLAIKGFRKDKHTEAAFQFANVADSYAANSAQGDVRNTGVIGFAAFELQGPAQNTLPPCSGQAFPADNNGYAPPPCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C42</accession>
    <name>Q32C42_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type II secretion system protein H</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">General secretion pathway protein H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gspH</name>
        <name evidence="13" type="ordered locus">SDY_3097</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404604.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C42"/>
    <dbReference type="STRING" id="300267.SDY_3097"/>
    <dbReference type="EnsemblBacteria" id="ABB63113">
        <property type="protein sequence ID" value="ABB63113"/>
        <property type="gene ID" value="SDY_3097"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3097"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3706"/>
    <dbReference type="HOGENOM" id="CLU_124364_0_0_6"/>
    <dbReference type="OMA" id="APGYQFM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022346">
        <property type="entry name" value="T2SS_GspH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12019">
        <property type="entry name" value="GspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220640" description="Type II secretion system protein H" evidence="11">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="GspH" evidence="12">
        <location>
            <begin position="29"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="176" mass="19831" checksum="AEA713455165DBA6" modified="2005-12-06" version="1">MLVIFLIGLASAGVVQTFATASESPAKKAAQDFLTRFAQFKDWAVIDGQTLGVLIDPPGYQFMQRRHGQWLPVSATRLSAQVTVPKQVQMLLQPGSDIWQKEYALELQRRRLTLHDIELELQKEAKKKTPQIRFSPFEPATPFTLRFYSAAQNACWAVKLAHDGALSLSQCDERMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C74</accession>
    <name>Q32C74_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yghB</name>
        <name evidence="4" type="ordered locus">SDY_3064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000268435.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404572.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C74"/>
    <dbReference type="STRING" id="300267.SDY_3064"/>
    <dbReference type="EnsemblBacteria" id="ABB63081">
        <property type="protein sequence ID" value="ABB63081"/>
        <property type="gene ID" value="SDY_3064"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3064"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3670"/>
    <dbReference type="HOGENOM" id="CLU_044208_6_2_6"/>
    <dbReference type="OMA" id="FMPLACG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="24164" checksum="9DD47951DB24BFD9" modified="2005-12-06" version="1">MAVIQDIIAALWQHDFAALADPHIVSVVYFVMFATLFLENGLLPTSFLPGDSLLILAGALIAQGVMDFLPTIAILTAAASLGCWLSYIQGRWLGNTKTVKGWLAQLPAKYHQRATCMFDRHGLLALLAGRFLAFVRTLLPTMAGISGLPNRRFQFFNWLSGLLWVSVVTSFGYALSMIPFVKRHEDQVMTFLMILPIALLTAGLLGTLFVVIKKKYCNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CB4</accession>
    <name>FUCM_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-fucose mutarotase</fullName>
            <ecNumber evidence="1">5.1.3.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Fucose 1-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type-2 mutarotase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fucU</name>
        <name type="ordered locus">SDY_3022</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the anomeric conversion of L-fucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-L-fucose = beta-L-fucose</text>
            <dbReference type="Rhea" id="RHEA:25580"/>
            <dbReference type="ChEBI" id="CHEBI:42548"/>
            <dbReference type="ChEBI" id="CHEBI:42589"/>
            <dbReference type="EC" id="5.1.3.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; L-fucose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodecamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbsD / FucU family. FucU mutarotase subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.29" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000920840.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404532.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CB4"/>
    <dbReference type="SMR" id="Q32CB4"/>
    <dbReference type="STRING" id="300267.SDY_3022"/>
    <dbReference type="EnsemblBacteria" id="ABB63041">
        <property type="protein sequence ID" value="ABB63041"/>
        <property type="gene ID" value="SDY_3022"/>
    </dbReference>
    <dbReference type="GeneID" id="66673329"/>
    <dbReference type="KEGG" id="sdy:SDY_3022"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3628"/>
    <dbReference type="HOGENOM" id="CLU_120075_1_0_6"/>
    <dbReference type="OMA" id="MGHGDDI"/>
    <dbReference type="UniPathway" id="UPA00956"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036373">
        <property type="term" value="F:L-fucose mutarotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042354">
        <property type="term" value="P:L-fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01662">
        <property type="entry name" value="L_fucose_rotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023751">
        <property type="entry name" value="L-fucose_mutarotase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0294">Fucose metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000187206" description="L-fucose mutarotase">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01662"/>
        </source>
    </evidence>
    <sequence length="140" mass="15473" checksum="55D304F7BF17B8F4" modified="2005-12-06" version="1">MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CG1</accession>
    <name>Q32CG1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FixC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ygcN</name>
        <name evidence="5" type="ordered locus">SDY_2968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of an electron transfer system.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404485.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CG1"/>
    <dbReference type="STRING" id="300267.SDY_2968"/>
    <dbReference type="EnsemblBacteria" id="ABB62994">
        <property type="protein sequence ID" value="ABB62994"/>
        <property type="gene ID" value="SDY_2968"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2968"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3560"/>
    <dbReference type="HOGENOM" id="CLU_050977_0_0_6"/>
    <dbReference type="OMA" id="LLEYGCH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="PTHR43624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="4">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="433" mass="47432" checksum="5BCA71F5CCCA2DEB" modified="2005-12-06" version="1">MLCSGYLGHDMEDDCDIIIIGAGIAGTACALRCARAGLSVLLLERAEIPGSKNLSGGRLYTHALAELLPQFHLTAPLERRITHESLSLLTPDCATTFSSLQPGGESWSVLRARFDPWLVAEAEKEGVECIPGATVDALYEENGRVCGVICGDDILRARYVVLAEGANSVLTERHGLVTRPAGEAMALGIKEVLSLETSAIEERFHLENNEGAALLFSGGICDDFPGGAFLYTNQQTLSLGIVCPRSSLTQSRVPASELLARFKTHPAVRPLIKNTESLEYGAHLVPEGGLHSMPVQYAGNGWLLVGDALRSCVNTGISVRGMDMALTGAQAAAQTLISACQHHEPQNLFPLYHHNVERSLLWDVLQRYQHVPALLQRPGWYRAWPALMQDISRDLWDQGDKPVPPLRQLLWRHLRRHGLWHLAGDVIRSLRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CL2</accession>
    <name>Q32CL2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HycI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hycI</name>
        <name evidence="2" type="ordered locus">SDY_2914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000132960.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404434.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CL2"/>
    <dbReference type="STRING" id="300267.SDY_2914"/>
    <dbReference type="MEROPS" id="A31.003"/>
    <dbReference type="EnsemblBacteria" id="ABB62943">
        <property type="protein sequence ID" value="ABB62943"/>
        <property type="gene ID" value="SDY_2914"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2914"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3501"/>
    <dbReference type="HOGENOM" id="CLU_099037_4_0_6"/>
    <dbReference type="OMA" id="EMCAANP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06067">
        <property type="entry name" value="H2MP_MemB-H2evol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004420">
        <property type="entry name" value="Pept_A31_hyd_mat_HycI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00142">
        <property type="entry name" value="hycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="155" mass="16927" checksum="B90535AFC0F30DDE" modified="2005-12-06" version="1">MTDVLLCVGNSMMGDDGAGPLLAEKCAAAPKGNWVVIDGGSAPENDIVAIRELRPTRLLIVDATDMGLNPGEIRIIDPDDIAEMFMMTTHNMPLNYLIDQLKEDIGEVIFLGIQPDIVGFYYPMTQPIKDAVETVYQRLEGWEGNGGFAQLAVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CL5</accession>
    <name>Q32CL5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AscBF operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ascG</name>
        <name evidence="6" type="ordered locus">SDY_2911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404431.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CL5"/>
    <dbReference type="STRING" id="300267.SDY_2911"/>
    <dbReference type="EnsemblBacteria" id="ABB62940">
        <property type="protein sequence ID" value="ABB62940"/>
        <property type="gene ID" value="SDY_2911"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2911"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3496"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_6"/>
    <dbReference type="OMA" id="SHCVWSD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="337" mass="36856" checksum="E77A33C79CC8E5E7" modified="2005-12-06" version="1">MMTTMLEVAKRAGVSKATVSRVLSGNGYVSQETKDRVFQAVEESGYRPNLLARNLSAKSTQTLGLVVTNTLYHGIYFSELLFHAARMAEEKGRQLLLADGKHSAEEERQAIQYLLDLRCDAIMIYPRFLSVDEIDDIIDAHSQPIMVLNRRLRKNSSHSVWCDHKQTSFNAVAELINAGHQEIAFLTGSMDSPTSVERLAGYKDALAQHGIALNEKLIANGKWTPASGAEGVETLLEHGAKFSALVASNDDMAIGAMKALHERGVAVPEQVSVIGFDDIAIAPYIVPALSSVKIPVTEMIQEIIGRLIFMLDGGDFSPPKTFSGKLICRDSLIALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CM1</accession>
    <name>Q32CM1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator for glucitol operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srlR</name>
        <name evidence="5" type="ordered locus">SDY_2904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000804551.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404425.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CM1"/>
    <dbReference type="STRING" id="300267.SDY_2904"/>
    <dbReference type="EnsemblBacteria" id="ABB62934">
        <property type="protein sequence ID" value="ABB62934"/>
        <property type="gene ID" value="SDY_2904"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2904"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3489"/>
    <dbReference type="HOGENOM" id="CLU_060699_0_1_6"/>
    <dbReference type="OMA" id="KHGQEHF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="257" mass="28236" checksum="BAEAB36B51DD27A0" modified="2005-12-06" version="1">MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKELIAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENAFEHFTFDKLFMGTDGIDLNAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQALEEKGLDVIITGESNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CN1</accession>
    <name>SYA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="1">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">alaS</name>
        <name type="ordered locus">SDY_2893</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000047160.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404415.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CN1"/>
    <dbReference type="SMR" id="Q32CN1"/>
    <dbReference type="STRING" id="300267.SDY_2893"/>
    <dbReference type="EnsemblBacteria" id="ABB62924">
        <property type="protein sequence ID" value="ABB62924"/>
        <property type="gene ID" value="SDY_2893"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2893"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3474"/>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_6"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000347798" description="Alanine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="666"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <sequence length="876" mass="95988" checksum="7D958F271EE0FD33" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CT6</accession>
    <name>Q32CT6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-uridine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yfiP</name>
        <name evidence="6" type="ordered locus">SDY_2826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404360.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CT6"/>
    <dbReference type="STRING" id="300267.SDY_2826"/>
    <dbReference type="EnsemblBacteria" id="ABB62869">
        <property type="protein sequence ID" value="ABB62869"/>
        <property type="gene ID" value="SDY_2826"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2826"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3403"/>
    <dbReference type="HOGENOM" id="CLU_066458_1_0_6"/>
    <dbReference type="OMA" id="WQPYVVF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039262">
        <property type="entry name" value="DTWD2/YfiP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392">
        <property type="entry name" value="PTHR21392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="5">
        <location>
            <begin position="35"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="240" mass="26990" checksum="E070088601C5BEE4" modified="2005-12-06" version="1">MAFFRRSLMTENAVLQLRAERIARATRPFLARGNRVRRCQRCLLPEKLCLCSTITPAQAKSRFCLLMFDTEPMKPSNTGRLIADILPDTVAFQWSRTEPSQDLLDLVQNPDYQPMVVFPASYADEQREVIFTPPAGKPPLFIMLDGTWPEARKMFRKSPYLDNLPVISVDLSRLSAYRLREAQAEGQYCTAEVAIALLDMAGDTGAAAGLGEHFTRFKTRYLAGKTQHLGSITAEQLESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D10</accession>
    <name>Q32D10_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_2752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404286.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D10"/>
    <dbReference type="STRING" id="300267.SDY_2752"/>
    <dbReference type="EnsemblBacteria" id="ABB62795">
        <property type="protein sequence ID" value="ABB62795"/>
        <property type="gene ID" value="SDY_2752"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2752"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3319"/>
    <dbReference type="HOGENOM" id="CLU_010686_8_0_6"/>
    <dbReference type="OMA" id="MALKMYD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="146" mass="16400" checksum="EF8A678FA68EA0AA" modified="2005-12-06" version="1">MLIGYVRVSTNDQNTDLQRNALNCAGCELIFEDKISGTKSERPGLKKLLRTLSAGDTLVVWKLDRLGRSMRHLVVLVEELRERGINFRSLTDSIDTSTPMGRFFFHVMGALAEMERELIVERTKAGLEAARAQGRIGGRRPKLSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D77</accession>
    <name>Q32D77_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404219.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D77"/>
    <dbReference type="STRING" id="300267.SDY_2679"/>
    <dbReference type="EnsemblBacteria" id="ABB62728">
        <property type="protein sequence ID" value="ABB62728"/>
        <property type="gene ID" value="SDY_2679"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2679"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3232"/>
    <dbReference type="HOGENOM" id="CLU_121340_0_0_6"/>
    <dbReference type="OMA" id="WSLRQKF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010005">
        <property type="entry name" value="Formate_DH_maturation_HycH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07450">
        <property type="entry name" value="HycH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="158" mass="17869" checksum="F671FC7386913570" modified="2005-12-06" version="1">MPTIHVSIVSFSNSFAYSGGYMTEECGEIVFWTLRKKFVASSDEMPEHSSQVMYYSLAIGHHVGVIDCLNVAFRCPLTEYKDWLALVEEEQARCKMLRVMTFGEIVIDASHTALLTRAFAPLADDATSVWQARSIQFIHLLDEIVQEPAIYLMARKIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D90</accession>
    <name>PUR7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="1">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purC</name>
        <name type="ordered locus">SDY_2664</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378820.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404206.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D90"/>
    <dbReference type="SMR" id="Q32D90"/>
    <dbReference type="STRING" id="300267.SDY_2664"/>
    <dbReference type="EnsemblBacteria" id="ABB62715">
        <property type="protein sequence ID" value="ABB62715"/>
        <property type="gene ID" value="SDY_2664"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2664"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3215"/>
    <dbReference type="HOGENOM" id="CLU_061495_2_1_6"/>
    <dbReference type="OMA" id="EFCYKND"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01415">
        <property type="entry name" value="SAICAR_synt_PurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033934">
        <property type="entry name" value="SAICAR_synt_PurC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000018778" description="Phosphoribosylaminoimidazole-succinocarboxamide synthase">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <sequence length="237" mass="26969" checksum="2F7250A84CBE1AF4" modified="2005-12-06" version="1">MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDCKGMVNNKFNYFIMNKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DB3</accession>
    <name>EUTC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ethanolamine ammonia-lyase small subunit</fullName>
            <shortName evidence="1">EAL small subunit</shortName>
            <ecNumber evidence="1">4.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eutC</name>
        <name type="ordered locus">SDY_2638</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ethanolamine = acetaldehyde + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15313"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="EC" id="4.3.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
        <text evidence="1">Binds between the large and small subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine degradation; ethanolamine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EutC family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000372372.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404183.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DB3"/>
    <dbReference type="SMR" id="Q32DB3"/>
    <dbReference type="STRING" id="300267.SDY_2638"/>
    <dbReference type="EnsemblBacteria" id="ABB62692">
        <property type="protein sequence ID" value="ABB62692"/>
        <property type="gene ID" value="SDY_2638"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2638"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3176"/>
    <dbReference type="HOGENOM" id="CLU_068224_0_0_6"/>
    <dbReference type="OMA" id="ADRNCVS"/>
    <dbReference type="UniPathway" id="UPA00560"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009350">
        <property type="term" value="C:ethanolamine ammonia-lyase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031471">
        <property type="term" value="C:ethanolamine degradation polyhedral organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008851">
        <property type="term" value="F:ethanolamine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046336">
        <property type="term" value="P:ethanolamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00601">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009246">
        <property type="entry name" value="EutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042251">
        <property type="entry name" value="EutC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39330">
        <property type="entry name" value="PTHR39330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05985">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018982">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1283">Bacterial microcompartment</keyword>
    <keyword id="KW-0846">Cobalamin</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000025865" description="Ethanolamine ammonia-lyase small subunit">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00601"/>
        </source>
    </evidence>
    <sequence length="295" mass="31787" checksum="E1D35D39632B4471" modified="2005-12-06" version="1">MDQKQIEEIVRSVMASMGQTAPAPSEAKCTTTTCAAPVTSESCALDLGSAEAKAWIGVENPHRADVLTELRRSTVARVCTGRAGPRPRTQALLRFLADHSRSKDTVLKEVPEEWGKAQGLLEVRSEISDKNLYLTRPDMGRRLCAEAVEALKAQCVANPDVQVVISDGLSTDAITVNYEEILPPLMAGLKQAGLKVGTPFFVRYGRVKIEDQIGEILGAKVVILLVGERPGLGQSESLSCYAVYSPRMATTVEADRTCISNIHQGGTPPVEAAAVIVDLAKRMLEQKASGINMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DR7</accession>
    <name>Q32DR7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DR7"/>
    <dbReference type="STRING" id="300267.SDY_2468"/>
    <dbReference type="EnsemblBacteria" id="ABB62538">
        <property type="protein sequence ID" value="ABB62538"/>
        <property type="gene ID" value="SDY_2468"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2468"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="13174" checksum="5666CA26C065C0F1" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIRMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKVMTLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DU8</accession>
    <name>Q32DU8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase, periplasmic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glpQ</name>
        <name evidence="3" type="ordered locus">SDY_2434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000779098.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403998.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DU8"/>
    <dbReference type="STRING" id="300267.SDY_2434"/>
    <dbReference type="EnsemblBacteria" id="ABB62507">
        <property type="protein sequence ID" value="ABB62507"/>
        <property type="gene ID" value="SDY_2434"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2434"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2933"/>
    <dbReference type="HOGENOM" id="CLU_030226_1_0_6"/>
    <dbReference type="OMA" id="CRHENDI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220928" evidence="1">
        <location>
            <begin position="26"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="31"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="359" mass="41034" checksum="B5D78B994562E9E7" modified="2005-12-06" version="1">MKLTLKNLSMAIMMSTIVMGSSAMAADSNEKIVIAHRGASGYLPEHTLPAKAMAYAQGADYLEQDLVMTKDDHLVVLHDHYLDRVTDVADRFPDRVRKDGRYYAIDFTLDEIKLLKFTEGFDIENGKKVQTYPGRFPMGKSDFRVHTFEEEIEFVQGLNHSTGKNIGIYPEIKAPWFHHQEGKDIAAKTLEVLKKYGYTGKDDKVYLQCFDADELKRIKNELEPKMGMDLNLVQLIAYTDWNETQQKQPDGSWVNYNYDWMFKPGAMKQVAEYADGIGPDYHMLIEETSQPGNIKLTGMVQDAQQNKLVVHPYTVRSDKLPEYTTDVNQLYDALYNKAGVNGLFTDFPDKAVKFLHKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E55</accession>
    <name>Q32E55_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ycbM</name>
        <name evidence="8" type="ordered locus">SDY_2323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000235210.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403891.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E55"/>
    <dbReference type="STRING" id="300267.SDY_2323"/>
    <dbReference type="EnsemblBacteria" id="ABB62400">
        <property type="protein sequence ID" value="ABB62400"/>
        <property type="gene ID" value="SDY_2323"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2323"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2803"/>
    <dbReference type="HOGENOM" id="CLU_046113_1_2_6"/>
    <dbReference type="OMA" id="LRWHPGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="58"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="263" mass="28986" checksum="15F17088918E2303" modified="2005-12-06" version="1">MATPVKKWLLRVAPWFLPVGIVTVWQLASSVGWLSTRILPSPEGVVMAFWTLSASGELWQHLAISSWRALIGFSIGGSLGLILGLISGLSRWGERLLDTSIQMLRNVPHLALIPLVILWFGIDESAKIFLVALGTLFPIYINTWHGIRNIDRGLVEMARSYGLSGIPLFIHVILPGALPSIMVGVRFALGLMWLTLIVAETISANSGIGYLAMNAREFLQTDVVVVAIILYALLGKLADVSAQLLERLWLRWNPAYHLKEATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E78</accession>
    <name>Q32E78_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yceK</name>
        <name evidence="1" type="ordered locus">SDY_2300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001237205.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403868.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E78"/>
    <dbReference type="STRING" id="300267.SDY_2300"/>
    <dbReference type="EnsemblBacteria" id="ABB62377">
        <property type="protein sequence ID" value="ABB62377"/>
        <property type="gene ID" value="SDY_2300"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2300"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2776"/>
    <dbReference type="HOGENOM" id="CLU_164795_0_0_6"/>
    <dbReference type="OMA" id="PWRFIAI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010780">
        <property type="entry name" value="DUF1375"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07119">
        <property type="entry name" value="DUF1375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8443" checksum="8675E471F5676689" modified="2005-12-06" version="1">MRLIVVSIMVTLLSGCGSIISRTIPGQGHGNQYYPGVQWDVRDSAWRYVTILDLPFSLVFDTLLLPIDIHHGPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EB5</accession>
    <name>Q32EB5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403831.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EB5"/>
    <dbReference type="EnsemblBacteria" id="ABB62340">
        <property type="protein sequence ID" value="ABB62340"/>
        <property type="gene ID" value="SDY_2260"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2260"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2729"/>
    <dbReference type="HOGENOM" id="CLU_152461_0_0_6"/>
    <dbReference type="OMA" id="YLNTRAC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016501">
        <property type="entry name" value="UCP007004"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007004">
        <property type="entry name" value="UCP007004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="110" mass="11896" checksum="FCBF54074044C44C" modified="2005-12-06" version="1">MGKGEMKKIAAISLISIFIMSGCAVHNDETSIGKFGLAYKSNIQRKLDNQYYTEAEASLARGRISGAENIVKNDAAHFCVTQGKKMQIVDLKTEGAGLHGVARLTFKCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EC2</accession>
    <name>Q32EC2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP nucleosidase</fullName>
            <ecNumber evidence="1">3.2.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">amn</name>
        <name evidence="4" type="ordered locus">SDY_2253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + H2O = adenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:20129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.2.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AMP nucleosidase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001060215.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403824.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EC2"/>
    <dbReference type="STRING" id="300267.SDY_2253"/>
    <dbReference type="EnsemblBacteria" id="ABB62333">
        <property type="protein sequence ID" value="ABB62333"/>
        <property type="gene ID" value="SDY_2253"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2253"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2721"/>
    <dbReference type="HOGENOM" id="CLU_026838_1_0_6"/>
    <dbReference type="OMA" id="RPHAWIM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008714">
        <property type="term" value="F:AMP nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01932">
        <property type="entry name" value="AMP_nucleosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037109">
        <property type="entry name" value="AMP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011271">
        <property type="entry name" value="AMP_nucleosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018953">
        <property type="entry name" value="AMP_nucleoside_Pase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF6">
        <property type="entry name" value="PTHR43691:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10423">
        <property type="entry name" value="AMNp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01717">
        <property type="entry name" value="AMP-nucleosdse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMNp_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="267"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="484" mass="54096" checksum="8FACF486A1878BAE" modified="2005-12-06" version="1">MNNKGSGLTPAQALDKLDALYEQSVVALRNAIGKYIRSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTCAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPWQHEIPYPYVIDGSELTLDRSMSAGLTRYFPTTELAQIGDETADGIYHPTEFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLLSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSQAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKLPGQANRFYEGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EE5</accession>
    <name>Q32EE5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EE5"/>
    <dbReference type="EnsemblBacteria" id="ABB62310">
        <property type="protein sequence ID" value="ABB62310"/>
        <property type="gene ID" value="SDY_2225"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2225"/>
    <dbReference type="HOGENOM" id="CLU_2156644_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="111" mass="11985" checksum="63AC1841B13B9AF1" modified="2005-12-06" version="1">MGDTAQAGASTASQLLDEQEAITVFDFKTKLELQISGLGCGYLPRYLAQRFLDSGALIEKKVVAQTLFEPVWIGWNEQTAGLASGWWRDEILANSAIAGVYAKSDDGKSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EF9</accession>
    <name>Q32EF9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhamnosyl transferase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbQ</name>
        <name evidence="2" type="ordered locus">SDY_2211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000592106.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403787.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EF9"/>
    <dbReference type="STRING" id="300267.SDY_2211"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62296">
        <property type="protein sequence ID" value="ABB62296"/>
        <property type="gene ID" value="SDY_2211"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2211"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2674"/>
    <dbReference type="HOGENOM" id="CLU_023845_9_1_6"/>
    <dbReference type="OMA" id="FARVGPF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006446">
        <property type="entry name" value="RhaTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01556">
        <property type="entry name" value="rhamnosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="303" mass="35211" checksum="4C25D94035A2F5B9" modified="2005-12-06" version="1">MIKKKVAAIIITYNPDLTILRESYTSLYKQVDKIILIDNNSTNYQELKKLFEKKEKIKIVPLSDNIGLAAAQNLGLNLAIKNNYTYAILFDQDSVLQDNGINSFFFEFEKLVSEEKLNIVAIGPSFFDEKTGRRFRPTKFIGPFLYPFRKITTKNPLTEVDFLIASGCFIKLECIKSAGMMTESLFIDYIDVEWSYRMRSYGYKLYIHNDIHMSHLVGESRVNLGLKTISLHGPLRRYYLFRNYISILKVRYIPLGYKIREGFFNIGRFLVSMIITKNRKTLILYTIKAIKDGINNEMGKYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EQ1</accession>
    <name>Q32EQ1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0288</name>
        <name evidence="4" type="ordered locus">SDY_2114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60507">
        <property type="protein sequence ID" value="ABB60507"/>
        <property type="gene ID" value="SDY_0288"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62204">
        <property type="protein sequence ID" value="ABB62204"/>
        <property type="gene ID" value="SDY_2114"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0288"/>
    <dbReference type="KEGG" id="sdy:SDY_2114"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="118" mass="13431" checksum="B3D46999C038FD04" modified="2005-12-06" version="1">MAVKPGNTGSGTRITPKQGGVLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EW1</accession>
    <name>Q32EW1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PTS system glucose-specific EIICB component</fullName>
            <ecNumber evidence="3">2.7.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">EIICB-Glc</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ptsG</name>
        <name evidence="19" type="ordered locus">SDY_2049</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucose 6-phosphate(in) + L-histidyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:33367"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.199" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000475719.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403635.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EW1"/>
    <dbReference type="SMR" id="Q32EW1"/>
    <dbReference type="STRING" id="300267.SDY_2049"/>
    <dbReference type="EnsemblBacteria" id="ABB62144">
        <property type="protein sequence ID" value="ABB62144"/>
        <property type="gene ID" value="SDY_2049"/>
    </dbReference>
    <dbReference type="GeneID" id="66670633"/>
    <dbReference type="KEGG" id="sdy:SDY_2049"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2464"/>
    <dbReference type="HOGENOM" id="CLU_012312_1_0_6"/>
    <dbReference type="OMA" id="AWAFNRF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005355">
        <property type="term" value="F:glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011299">
        <property type="entry name" value="PTS_IIBC_glc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004719">
        <property type="entry name" value="PTS_maltose/Glc_sub_IIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00852">
        <property type="entry name" value="pts-Glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02002">
        <property type="entry name" value="PTS-II-BC-glcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="18">
        <location>
            <begin position="3"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="17">
        <location>
            <begin position="399"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="15">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABB62144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="477" mass="50677" checksum="D97A80FD64B74F73" modified="2005-12-06" version="1">MFKNAFANLQKVGKSLMLPVSVLPIAGILLGVGSANFSWLPAVVSHVMAEAGGSVFANMPLIFAIGVALGFTNNDGVSALAAVVAYGIMVKTMAVVAPLVLHLPAEEIASKHLADTGVLGGIISGAIAAYMFNRFYRIKLPEYLGFFAGKRFVPIISGLAAIFTGVVLSFIWPPIGSAIQTFSQWAAYQNPVVAFGIYGFIERCLVPFGLHHIWNVPFQMQIGEYTNAAGQVFHGDIPRYMAGDPTAGKLSGGFLFKMYGLPAAAIAIWHSAKPENRAKVGGIMISAALTSFLTGITEPIEFSFMFVAPILYIIHAILAGLAFPICILLGMRDGTSFSHGLIDFIVLSGNSSKLWLFPIVGIGYAIVYYTIFRVLIKALDLKTPGREDATEDAKATGTSEMAPALVAAFGGKENITNLDACITRLRVSVADVSKVDQAGLKKLGAAGVVVAGSGVQAIFGTKSDNLKTEMDEYIRNH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EX7</accession>
    <name>LOLD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="1">7.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lolD</name>
        <name type="ordered locus">SDY_2033</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62128" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="7.6.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62128.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001033709.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403619.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EX7"/>
    <dbReference type="SMR" id="Q32EX7"/>
    <dbReference type="STRING" id="300267.SDY_2033"/>
    <dbReference type="PRIDE" id="Q32EX7"/>
    <dbReference type="EnsemblBacteria" id="ABB62128">
        <property type="protein sequence ID" value="ABB62128"/>
        <property type="gene ID" value="SDY_2033"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2033"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2446"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044873">
        <property type="term" value="P:lipoprotein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011924">
        <property type="entry name" value="LolD_lipo_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02211">
        <property type="entry name" value="LolD_lipo_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51244">
        <property type="entry name" value="LOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000272154" description="Lipoprotein-releasing system ATP-binding protein LolD">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="233" mass="25468" checksum="7D7FDBF209609AEC" modified="2007-01-23" version="2">MNKILLQCDNLCKRYQEGSVQTDVLHNVSFSVSEGEMMAIVGSSGSGKSTLLHLLGGLDTPTSGDVIFNGQPMSKLSSAAKAELRNQKLGFIYQFHHLLPDFTALENVAMPLLIGKKKPAEINSRALEMLKAVGLDHRANHRPSELSGGERQRVAIARALVNNPRLVLADEPTGNLDARNADSIFQLLGELNRLQGTAFLVVTHDLQLAKRMSRQLEMRDGRLTAELSLMGAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EY4</accession>
    <name>POTA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="1">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">potA</name>
        <name type="ordered locus">SDY_2026</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + polyamine-[polyamine-binding protein]Side 1 = ADP + phosphate + polyamineSide 2 + [polyamine-binding protein]Side 1.</text>
            <dbReference type="EC" id="7.6.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000531604.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403612.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EY4"/>
    <dbReference type="SMR" id="Q32EY4"/>
    <dbReference type="STRING" id="300267.SDY_2026"/>
    <dbReference type="EnsemblBacteria" id="ABB62121">
        <property type="protein sequence ID" value="ABB62121"/>
        <property type="gene ID" value="SDY_2026"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2026"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2439"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_6"/>
    <dbReference type="OMA" id="IHVMRFN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51305">
        <property type="entry name" value="POTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000286285" description="Spermidine/putrescine import ATP-binding protein PotA">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="18"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01726"/>
        </source>
    </evidence>
    <sequence length="378" mass="43018" checksum="04F199BFD4505601" modified="2005-12-06" version="1">MGQSKKLNKQPSSLSPLVQLAGIRKCFDGKEVISQLDLTINNGEFLTLLGPSGCGKTTVLRLIAGLETVDSGRIMLDNEDITHVPAENRYVNTVFQSYALFPHMTVFENVAFGLRMQKTPAAEITPRVMEALRMVQLETFAQRKPHQLSGGQQQRVAIARAVVNKPRLLLLDESLSALDYKLRKQMQNELKALQRKLGITFVFVTHDQEEALTMSDRIVVMRDGRIEQDGTPREIYEEPKNLFVAGFIGEINMFNATVIERLDEQRVRANVEGRECNIYVNFAVEPGQKLHVLLRPEDLRVEEINDDNHAEGLIGYVRERNYKGMTLESVVELENGKMVMVSEFFNEDDPDFDHSLDQKMAINWVESWEVVLADEEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F01</accession>
    <name>Q32F01_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F01"/>
    <dbReference type="EnsemblBacteria" id="ABB62104">
        <property type="protein sequence ID" value="ABB62104"/>
        <property type="gene ID" value="SDY_2009"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2009"/>
    <dbReference type="HOGENOM" id="CLU_027402_14_0_6"/>
    <dbReference type="OMA" id="QDGFNRS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="176" mass="20168" checksum="92465C644BAC2D04" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRRQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F04</accession>
    <name>Q32F04_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4376 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000388336.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403592.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F04"/>
    <dbReference type="EnsemblBacteria" id="ABB62101">
        <property type="protein sequence ID" value="ABB62101"/>
        <property type="gene ID" value="SDY_2006"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2006"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2418"/>
    <dbReference type="HOGENOM" id="CLU_110174_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025484">
        <property type="entry name" value="DUF4376"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14301">
        <property type="entry name" value="DUF4376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4376" evidence="1">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="10276" checksum="977F2851E77DF3C2" modified="2005-12-06" version="1">MEASPEIEAWRTEQEAKPFTFEWNGRVWNAGPNSLGRLYPVVMAAKSDIVRDVMTWSDADNQQVQLTMQELEGLATAMIQAIVDRNDEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FD9</accession>
    <name>Q32FD9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dipeptide and tripeptide permease A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ydgR</name>
        <name evidence="9" type="synonym">dtpA</name>
        <name evidence="11" type="ordered locus">SDY_1857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton-dependent permease that transports di- and tripeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000100952.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403457.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FD9"/>
    <dbReference type="STRING" id="300267.SDY_1857"/>
    <dbReference type="EnsemblBacteria" id="ABB61966">
        <property type="protein sequence ID" value="ABB61966"/>
        <property type="gene ID" value="SDY_1857"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1857"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2236"/>
    <dbReference type="HOGENOM" id="CLU_004790_0_0_6"/>
    <dbReference type="OMA" id="QMMGVWF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015333">
        <property type="term" value="F:peptide:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042937">
        <property type="term" value="F:tripeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01878">
        <property type="entry name" value="PTR2_DtpA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023517">
        <property type="entry name" value="AA/pep_transptr_DtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="22"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB61966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="500" mass="54057" checksum="241E4B4894F679EF" modified="2005-12-06" version="1">MSTANQKTTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTIIGIVALIAIATWLLHNQEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHTILGLAVEPEQYQALNPFWIIIGSPILAAIYNKMGDTLPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLFTAPKLHRMTQDDAADKAAKAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FF2</accession>
    <name>Q32FF2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FF2"/>
    <dbReference type="EnsemblBacteria" id="ABB61953">
        <property type="protein sequence ID" value="ABB61953"/>
        <property type="gene ID" value="SDY_1844"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1844"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8259" checksum="9BDAFB9964706261" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITRSCNPRSIRRCRQYCQPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-07" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FG8</accession>
    <name>TUS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication terminus site-binding protein</fullName>
            <shortName evidence="1">Ter-binding protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tus</name>
        <name type="ordered locus">SDY_1826</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tus family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022373.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403428.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FG8"/>
    <dbReference type="SMR" id="Q32FG8"/>
    <dbReference type="STRING" id="300267.SDY_1826"/>
    <dbReference type="EnsemblBacteria" id="ABB61937">
        <property type="protein sequence ID" value="ABB61937"/>
        <property type="gene ID" value="SDY_1826"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1826"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2199"/>
    <dbReference type="HOGENOM" id="CLU_078181_0_0_6"/>
    <dbReference type="OMA" id="QVQYACP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.14.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00483">
        <property type="entry name" value="Rep_term_Tus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008865">
        <property type="entry name" value="DNA_replication_term_site-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036381">
        <property type="entry name" value="Tus_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036384">
        <property type="entry name" value="Tus_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05472">
        <property type="entry name" value="Ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56596">
        <property type="entry name" value="SSF56596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02648">
        <property type="entry name" value="rep_term_tus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000049422" description="DNA replication terminus site-binding protein">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00483"/>
        </source>
    </evidence>
    <sequence length="309" mass="35678" checksum="E1606D5578522E7D" modified="2005-12-06" version="1">MARYDLVDRLNTTFRQMEQELAAFAAHLEQHKLLVARVFSLPEVKKEDEHNPLNRIEVKQHLGNDAHSLALRHFRHLFIQQQSENRSSKAAVRLPGVLCYQVDNLSQAALVSHIQHINKLKTTFEHIVTVESELPTAARFEWVHRHLPGLITLNAYRSLTVLHDPATLRFGWANKHIIKNLHRDEVLAQLEKSLKSPRSVAPWTREEWQRKLEREYQGIAALPQNAKLKIKRPVKVQPIARVWYKGDQKQVQHACPTPLIALINRDNGAGVPDVGELLNYDADNVQHRYKPQAQPLRLIIPRLHLYVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FK8</accession>
    <name>Q32FK8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_1783</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FK8"/>
    <dbReference type="STRING" id="300267.SDY_1783"/>
    <dbReference type="EnsemblBacteria" id="ABB61897">
        <property type="protein sequence ID" value="ABB61897"/>
        <property type="gene ID" value="SDY_1783"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1783"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_6"/>
    <dbReference type="OMA" id="LYREAPM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="139"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="246"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="401" mass="45273" checksum="E146C609EF563C35" modified="2005-12-06" version="1">MRRWVLSCLKRLINRSITMDFSLTEEQELLLASIRELITTNFPEEYFRTCDQNGTYPREFMRALADNGISMLGVPEEFGGIPADYVTQMLALMEVSKCGAPAFLITNGQCIHSMRRFGSAEQLRKTAESTLETGDPAYALALTEPDAGSDNNSATTTYTRKNGKVYINGQKTFITGAKEYPYMLVLARDPQPKDPKKAFTLWWVDSSKPGIKINPLHKIGWHMLSTCEVYLDNVEVEESDMVGEEGMGFLNVMYNFEMERLINAARSTGFAECAFEDAARYANQRIAFGKPIGHNQMIQEKLALMAIKIDNMRNMVLKVAWQADLHQSLRTSAALAKLYCARTAMEVIDDAIQIMGGLGYTDEARVSRFWRDVRCERIGGGTDEIMIYVAGRQILKDYQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FV3</accession>
    <name>Q32FV3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FV3"/>
    <dbReference type="EnsemblBacteria" id="ABB61802">
        <property type="protein sequence ID" value="ABB61802"/>
        <property type="gene ID" value="SDY_1681"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1681"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7488" checksum="CD3B248501336F70" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITKSLLPYRTWVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FY3</accession>
    <name>Q32FY3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FY3"/>
    <dbReference type="EnsemblBacteria" id="ABB61772">
        <property type="protein sequence ID" value="ABB61772"/>
        <property type="gene ID" value="SDY_1650"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1650"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8521" checksum="3EDDC5DFC48E75D4" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITHRIYRPGAEIRRVAYGLRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G24</accession>
    <name>Q32G24_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yddG</name>
        <name evidence="6" type="ordered locus">SDY_1603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000198226.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403222.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G24"/>
    <dbReference type="STRING" id="300267.SDY_1603"/>
    <dbReference type="EnsemblBacteria" id="ABB61731">
        <property type="protein sequence ID" value="ABB61731"/>
        <property type="gene ID" value="SDY_1603"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1603"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1926"/>
    <dbReference type="HOGENOM" id="CLU_058959_1_1_6"/>
    <dbReference type="OMA" id="VALWFHY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="5">
        <location>
            <begin position="158"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="293" mass="31605" checksum="BA04727EC9A149D3" modified="2005-12-06" version="1">MTRQKATLIGLIAIVLWSTMVGLIRGVSEGLGPVGGAAAIYSLSGLLLVFTVGFPRIRQIPKGYLLAGSLLFVSYEICLALSLGYAATRHQAIEVGMVNYLWPSLTILFAILFNGQKTNWLIVPGLLLALVGVCWVLGGDNGLHYDEIINNITTSPLSYFLAFIGAFIWAAYCTVTNKYARGFNGITVFVLLTGASLWVYYFLTPQPEMIFSMPVMIKLISAAFTLGFAYAAWNVGILHGNVTIMAVGSYFTPVLSSALAAVLLSAPLSFSFWQSALMVCGGSLLCWLATRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G90</accession>
    <name>Q32G90_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_1529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403156.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G90"/>
    <dbReference type="STRING" id="300267.SDY_1529"/>
    <dbReference type="EnsemblBacteria" id="ABB61665">
        <property type="protein sequence ID" value="ABB61665"/>
        <property type="gene ID" value="SDY_1529"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1529"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1831"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="99" mass="10768" checksum="60FB379250B4F507" modified="2005-12-06" version="1">MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVTLNTILRHLKNSARSRYLAHTAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GJ8</accession>
    <name>Q32GJ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydaA</name>
        <name evidence="2" type="ordered locus">SDY_1413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001252110.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403048.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GJ8"/>
    <dbReference type="STRING" id="300267.SDY_1413"/>
    <dbReference type="EnsemblBacteria" id="ABB61557">
        <property type="protein sequence ID" value="ABB61557"/>
        <property type="gene ID" value="SDY_1413"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1413"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1680"/>
    <dbReference type="HOGENOM" id="CLU_049301_1_2_6"/>
    <dbReference type="OMA" id="MAKYQNM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="173"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="316" mass="35755" checksum="962E2B275E0817AB" modified="2005-12-06" version="1">MAMYQNMLVVIDPNQDDQPALRRAVYLHQRIGGKIKAFLPIYDFSYEMTTLLSPDERTAMRQGVISQRTAWIHEQAKYYLNAGFPIEIKVVWHNRPFEAIIQEVISGGHDLVLKMAHQHDRLEAVIFTPTDWHLLRKCPSPVWMVKDQPWPEGGKALVAVNLASEEPYHNALNEKLVKETIELAEQVNHTEVHLVGAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGINENMTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGISAAFLGNTAEQVIDHLRCDLLVIKPDQYQTPVELDDEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GT4</accession>
    <name>Q32GT4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_1324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402962.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GT4"/>
    <dbReference type="EnsemblBacteria" id="ABB61471">
        <property type="protein sequence ID" value="ABB61471"/>
        <property type="gene ID" value="SDY_1324"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1324"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1571"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="DAVVIWM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14999" checksum="F064A6A600054B56" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVIRKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GY2</accession>
    <name>Q32GY2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NarL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">narL</name>
        <name evidence="5" type="ordered locus">SDY_1275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000070491.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402914.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GY2"/>
    <dbReference type="SMR" id="Q32GY2"/>
    <dbReference type="STRING" id="300267.SDY_1275"/>
    <dbReference type="EnsemblBacteria" id="ABB61423">
        <property type="protein sequence ID" value="ABB61423"/>
        <property type="gene ID" value="SDY_1275"/>
    </dbReference>
    <dbReference type="GeneID" id="60668739"/>
    <dbReference type="KEGG" id="sdy:SDY_1275"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1514"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_8_6"/>
    <dbReference type="OMA" id="LDKYATH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="216" mass="23927" checksum="7DED78E4EF7EC57D" modified="2005-12-06" version="1">MSNQEPATILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALHQAAAGEMVLSEALTPVLAASLRANRATTERDVNQLTPRERDILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQERIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GZ5</accession>
    <name>PRMC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="1">RF MTase</shortName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prmC</name>
        <name type="synonym">hemK</name>
        <name type="ordered locus">SDY_1261</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000456449.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402901.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GZ5"/>
    <dbReference type="SMR" id="Q32GZ5"/>
    <dbReference type="STRING" id="300267.SDY_1261"/>
    <dbReference type="EnsemblBacteria" id="ABB61410">
        <property type="protein sequence ID" value="ABB61410"/>
        <property type="gene ID" value="SDY_1261"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1261"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1498"/>
    <dbReference type="HOGENOM" id="CLU_018398_3_1_6"/>
    <dbReference type="OMA" id="FDARYWE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000414542" description="Release factor glutamine methyltransferase">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <sequence length="277" mass="31046" checksum="B82E42C330A6048D" modified="2005-12-06" version="1">MEYQHWLREAISQLQASESPRRDAEILLEHVTGKGRTFILAFGETQLTDEQCQQLDALLTRRRDGEPIAHLTGVREFWSLPLFVSPATLIPRPDTECLVEQALARLPEQPCRILDLGTGTGAIALALARERPDCEITAVDRMPDAVALAQRNAQHLAIKNIHILQSDWFSELAGQQFAMIVSNPPYIDEQDPHLQQGDVRFEPLTALVAADSGMADIVHIIEQSRNALVSGGFLLLEHGWQQGEAVRQAFILAGYHDVETCRDYGDNERVTLGRYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H08</accession>
    <name>Q32H08_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H08"/>
    <dbReference type="EnsemblBacteria" id="ABB61396">
        <property type="protein sequence ID" value="ABB61396"/>
        <property type="gene ID" value="SDY_1245"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1245"/>
    <dbReference type="HOGENOM" id="CLU_202454_0_0_6"/>
    <dbReference type="OMA" id="FCTSLNS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="7847" checksum="D47B47A5FEA51AC2" modified="2005-12-06" version="1">MQAGINAIFCGREGAGDFINHSPLAKPNKTVFKYQKTLVQDRTSCMIEITFCELTGILEKGIKGINNGERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H17</accession>
    <name>Q32H17_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H17"/>
    <dbReference type="STRING" id="300267.SDY_1237"/>
    <dbReference type="EnsemblBacteria" id="ABB61388">
        <property type="protein sequence ID" value="ABB61388"/>
        <property type="gene ID" value="SDY_1237"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1237"/>
    <dbReference type="HOGENOM" id="CLU_126855_0_0_6"/>
    <dbReference type="OMA" id="WAMISWR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="193" mass="22311" checksum="9444010F40958699" modified="2005-12-06" version="1">MAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITLPRCDIAVASRSTLVADMRQAMSKLNNQARLRVYTTHLVSTSFVSPAIQRAAGREVIELPNYIFALNVLYQMGIYAHVDFIRGQNCQQDNSTWERFEQNVSWSLGALNDDERERLYRWYQQQDARALAPASRDWALIWWDSVPQEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H42</accession>
    <name>Q32H42_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycgK</name>
        <name evidence="3" type="ordered locus">SDY_1210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000693755.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402854.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H42"/>
    <dbReference type="SMR" id="Q32H42"/>
    <dbReference type="STRING" id="300267.SDY_1210"/>
    <dbReference type="EnsemblBacteria" id="ABB61363">
        <property type="protein sequence ID" value="ABB61363"/>
        <property type="gene ID" value="SDY_1210"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1210"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1436"/>
    <dbReference type="HOGENOM" id="CLU_129252_0_0_6"/>
    <dbReference type="OMA" id="WMSINIK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007280">
        <property type="entry name" value="Peptidase_C_arc/bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04151">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221117" description="PPC domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PPC" evidence="2">
        <location>
            <begin position="48"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="133" mass="14807" checksum="59AD688820255C81" modified="2005-12-06" version="1">MKIKGISKAVLLLALLTSTSFAAGKNVNVEFRKGHSSAQYSGEIKGYDYDTYTFYAKKGQKVHVSISNEGADTYLFGPGIDDSVDLSRYSPELDSHGQYSLPASGKYELRVLQTRNDARKNKTKKYNVDIQIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HB3</accession>
    <name>PURT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formate-dependent phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="1">6.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5'-phosphoribosylglycinamide transformylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Formate-dependent GAR transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">GAR transformylase 2</fullName>
            <shortName evidence="1">GART 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-folate glycinamide ribonucleotide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylglycinamide formyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purT</name>
        <name type="ordered locus">SDY_1135</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24829"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:24830"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PurK/PurT family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000173490.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402783.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HB3"/>
    <dbReference type="SMR" id="Q32HB3"/>
    <dbReference type="STRING" id="300267.SDY_1135"/>
    <dbReference type="PRIDE" id="Q32HB3"/>
    <dbReference type="EnsemblBacteria" id="ABB61292">
        <property type="protein sequence ID" value="ABB61292"/>
        <property type="gene ID" value="SDY_1135"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1135"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1337"/>
    <dbReference type="HOGENOM" id="CLU_011534_1_3_6"/>
    <dbReference type="OMA" id="GMVTMIT"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043815">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase 2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01643">
        <property type="entry name" value="PurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005862">
        <property type="entry name" value="PurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01142">
        <property type="entry name" value="purT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000319239" description="Formate-dependent phosphoribosylglycinamide formyltransferase">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="1">
        <location>
            <begin position="119"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="160"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="362"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01643"/>
        </source>
    </evidence>
    <sequence length="392" mass="42407" checksum="B3AFCFC727AB2B8E" modified="2005-12-06" version="1">MTLLGTALRPAATRVMLLGSGELGKEVAIECQRLGVEVIAVDRYADAPAMHVAHRSHVINMLDGDALRRVVELEKPHYIVPEIEAIATDMLIQLEEEGLNVVPCARATKLTMNREGIRRLAAEELQLPTSTYRFSDSESLFREAVAAIGYPCIVKPVMSSSGKGQTFIRSAEQLAQAWEYAQQGGRAGAGRVIVEGVVKFDFEITLLTVSAVDGVHFCAPVGHRQEDGDYRESWQPQQMSPLALERAQEIARKVVLALGGYGLFGVELFVCGDEVIFSEVSPRPHDTGMVTLISQDLSEFALHVRAFLGLPVGGIRQYGPAASAVILPQLTSQNVTFDNVQNAVGADLQIRLFGKPEIDGSRRLGVALATAESVVDAIERAKHAAGQVKVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HH7</accession>
    <name>Q32HH7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402719.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HH7"/>
    <dbReference type="EnsemblBacteria" id="ABB61228">
        <property type="protein sequence ID" value="ABB61228"/>
        <property type="gene ID" value="SDY_1063"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1063"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1249"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="ITTIYHE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="261" mass="30174" checksum="C3B0E6760E2FD696" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQSGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSAFSRSATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HM5</accession>
    <name>Q32HM5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001234573.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402671.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HM5"/>
    <dbReference type="STRING" id="300267.SDY_1015"/>
    <dbReference type="EnsemblBacteria" id="ABB61180">
        <property type="protein sequence ID" value="ABB61180"/>
        <property type="gene ID" value="SDY_1015"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1015"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1183"/>
    <dbReference type="HOGENOM" id="CLU_059317_0_0_6"/>
    <dbReference type="OMA" id="IDQNVRL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026325">
        <property type="entry name" value="DUF932"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06067">
        <property type="entry name" value="DUF932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="273" mass="31204" checksum="E652C6F67C8A7646" modified="2005-12-06" version="1">MRLASRFGYAANQIRRDRPLTHEELMHHVPGIFGEEKHTSRSQNYTYIPTITVLESLQREGFQPFFACQTRVRDPGRRGYTKHMLRLRRAGEINGEHVPEIILLNSHDGTSSYQMLPGYFRFVCQNGGVCGQSLGEVRVPHRGNVVEKVIEGAYEMVGVFDRIEEKRDAMQSLVLPPPARQALAQAALTYRYGDEHQPVTTADILTPRRREDYGQDLWSAYQTIQENMLKGGISGRSARGKRIHTRAIHSIDTDIKLNRALWVMAETLLESMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HP8</accession>
    <name>Q32HP8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium/proline symporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Proline permease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">putP</name>
        <name evidence="12" type="ordered locus">SDY_0990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the sodium-dependent uptake of extracellular L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001018473.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402648.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HP8"/>
    <dbReference type="STRING" id="300267.SDY_0990"/>
    <dbReference type="EnsemblBacteria" id="ABB61157">
        <property type="protein sequence ID" value="ABB61157"/>
        <property type="gene ID" value="SDY_0990"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0990"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1155"/>
    <dbReference type="HOGENOM" id="CLU_018808_15_2_6"/>
    <dbReference type="OMA" id="AWKTKNT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005298">
        <property type="term" value="F:proline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031402">
        <property type="term" value="F:sodium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015824">
        <property type="term" value="P:proline transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11475">
        <property type="entry name" value="SLC5sbd_PutP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011851">
        <property type="entry name" value="Na/Pro_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02121">
        <property type="entry name" value="Na_Pro_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0769">Symport</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB61157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="502" mass="54317" checksum="BD9F3C92B2CFA6D0" modified="2005-12-06" version="1">MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIAIGLTLGAWINWKLVAGRLRVHTEYNNNALTLPDYFTGRFEDKSRILRIISALVILLFFTIYCASGIVAGACLFESTFGMSYETALWVGAAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFGDSLEVIKQKSIENVDMLKGLNFVAIISLMGWGLGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNEHPAVAGAVNQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGRVMVLVVALVAIALAANPENRVLGLVSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGALTVIVWKQFGWLGLYEIIPGFIFGSIGIVVFSLLGKAPSAVMQKRFAEADAHYHSAPPSRLQEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HQ2</accession>
    <name>RUTD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative carbamate hydrolase RutD</fullName>
            <ecNumber evidence="1">3.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rutD</name>
        <name type="ordered locus">SDY_0984</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pyrimidine catabolism. May facilitate the hydrolysis of carbamate, a reaction that can also occur spontaneously.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>carbamate + 2 H(+) = CO2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15649"/>
            <dbReference type="ChEBI" id="CHEBI:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Hydrolase RutD family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402644.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HQ2"/>
    <dbReference type="SMR" id="Q32HQ2"/>
    <dbReference type="STRING" id="300267.SDY_0984"/>
    <dbReference type="ESTHER" id="shifl-YCDJ">
        <property type="family name" value="RutD"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61153">
        <property type="protein sequence ID" value="ABB61153"/>
        <property type="gene ID" value="SDY_0984"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0984"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1144"/>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_6"/>
    <dbReference type="OMA" id="HAMSVTD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00832">
        <property type="entry name" value="RutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019913">
        <property type="entry name" value="Pyrimidine_utilisation_RutD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03611">
        <property type="entry name" value="RutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000402981" description="Putative carbamate hydrolase RutD">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00832"/>
        </source>
    </evidence>
    <sequence length="224" mass="24355" checksum="57211BA79799644D" modified="2005-12-06" version="1">MKLSLSPPPYADAPVVVLISGLGGSGSYWLPQLAVLEQEYQVVCYDQRGTGNNPDTLAEDYSIAQMAAELHQALVAAGIEHYAVVGHALGALVGMQLALDYPASVTVLVSVNGWLRINAHTRRCFQVRERLLYSGGAQAWVEAQPLFLYPADWMAARAPRLEAEDALALAHFQGKNNLLRRLNALKRADFSHHADRIRCPVQIICASDDLLVPSACSSELHAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HY1</accession>
    <name>Q32HY1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yejG</name>
        <name evidence="1" type="ordered locus">SDY_0898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000202798.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402565.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HY1"/>
    <dbReference type="SMR" id="Q32HY1"/>
    <dbReference type="STRING" id="300267.SDY_0898"/>
    <dbReference type="EnsemblBacteria" id="ABB61074">
        <property type="protein sequence ID" value="ABB61074"/>
        <property type="gene ID" value="SDY_0898"/>
    </dbReference>
    <dbReference type="GeneID" id="66673922"/>
    <dbReference type="KEGG" id="sdy:SDY_0898"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1039"/>
    <dbReference type="HOGENOM" id="CLU_170187_0_0_6"/>
    <dbReference type="OMA" id="DESAAMC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020489">
        <property type="entry name" value="Uncharacterised_YejG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13989">
        <property type="entry name" value="YejG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="114" mass="12525" checksum="7856BED86851D7DB" modified="2005-12-06" version="1">MTSLQLSIVHRLPQNYRWSAGFAGSKVEPIPQNGPCGDNSLVALKLLSPDGDNAWSVMYKLSQALSDIEVPCSVLECEGEPCLFVNRQDEFAATCRLKNFGVAIAEPFSNYNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I97</accession>
    <name>Q32I97_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybiT</name>
        <name evidence="5" type="ordered locus">SDY_0776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000961450.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402449.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I97"/>
    <dbReference type="STRING" id="300267.SDY_0776"/>
    <dbReference type="EnsemblBacteria" id="ABB60960">
        <property type="protein sequence ID" value="ABB60960"/>
        <property type="gene ID" value="SDY_0776"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0776"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.894"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_6"/>
    <dbReference type="OMA" id="DWMGQWT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="320"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="530" mass="59874" checksum="C73BE047413F4ED1" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IA4</accession>
    <name>Q32IA4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402442.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IA4"/>
    <dbReference type="STRING" id="300267.SDY_0769"/>
    <dbReference type="EnsemblBacteria" id="ABB60953">
        <property type="protein sequence ID" value="ABB60953"/>
        <property type="gene ID" value="SDY_0769"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0769"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.885"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="RDGHERC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27513" checksum="73F06EC83C9B2E91" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTPKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ID3</accession>
    <name>Q32ID3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">potG</name>
        <name evidence="8" type="synonym">potA</name>
        <name evidence="10" type="ordered locus">SDY_0740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000995999.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402413.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ID3"/>
    <dbReference type="STRING" id="300267.SDY_0740"/>
    <dbReference type="EnsemblBacteria" id="ABB60924">
        <property type="protein sequence ID" value="ABB60924"/>
        <property type="gene ID" value="SDY_0740"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0740"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.854"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_6"/>
    <dbReference type="OMA" id="RLHSGQM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015417">
        <property type="term" value="F:ABC-type polyamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="377" mass="41993" checksum="215AD6E9852BF6A2" modified="2005-12-06" version="1">MNDAIPRPQAKTRKALTPLLEIRNLTKSYDGQHAVDDVSLTIYKGEIFALLGASGCGKSTLLRMLAGFEQPSAGQIMLDGVDLSQVPPYLRPINMMFQSYALFPHMTVEQNIAFGLKQDKLPKAEIASRVNEMLGLVHMQEFAKRKPHQLSGGQRQRVALARSLAKRPKLLLLDEPMGALDKKLRDRMQLEVVDILERVGVTCVMVTHDQEEAMTMAGRIAIMNRGKFIQIGEPEEIYEHPTTRYSAEFIGSVNVFEGVLKERQEDGLVLYSPGLVHPLKVDADASVVDNVPVHVALRPEKIMLCEEPPANGCNFAVGEVIHIAYLGDLSVYHVRLKSGQMISAQLQNAHRHRKGLPTWGDEVRLCWEVDSCVVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IF1</accession>
    <name>Q32IF1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS911 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402395.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IF1"/>
    <dbReference type="STRING" id="300267.SDY_0722"/>
    <dbReference type="EnsemblBacteria" id="ABB60906">
        <property type="protein sequence ID" value="ABB60906"/>
        <property type="gene ID" value="SDY_0722"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0722"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.835"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_9_6"/>
    <dbReference type="OMA" id="AEFKHEA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13548" checksum="CA13C29613E11294" modified="2005-12-06" version="1">MSVKLRLPQCSPQNNTGAPMKKRNFSAEFKRESAQLVVDQNYTVADAAKAMDVGLSTMTRWVKQLRDERQGKTPKASPITPEQIEIRELRKKLQRIEMENEILKKATALLMSDSLNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IN2</accession>
    <name>Q32IN2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybfA</name>
        <name evidence="2" type="ordered locus">SDY_0635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000424924.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402314.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IN2"/>
    <dbReference type="STRING" id="300267.SDY_0635"/>
    <dbReference type="EnsemblBacteria" id="ABB60825">
        <property type="protein sequence ID" value="ABB60825"/>
        <property type="gene ID" value="SDY_0635"/>
    </dbReference>
    <dbReference type="GeneID" id="66671031"/>
    <dbReference type="KEGG" id="sdy:SDY_0635"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.741"/>
    <dbReference type="HOGENOM" id="CLU_179850_0_0_6"/>
    <dbReference type="OMA" id="DKPVWLE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019663">
        <property type="entry name" value="YbfA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10725">
        <property type="entry name" value="DUF2517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="68" mass="8275" checksum="60F3CB3BEE791B4B" modified="2005-12-06" version="1">MELYREYPAWLIFLRRTYAVAAGVLALPFMLFWKDRARFYSYLHRVWSKTSDKPVWMDQAEKATGDFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IU2</accession>
    <name>NADD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="1">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadD</name>
        <name type="ordered locus">SDY_0561</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000838887.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402254.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IU2"/>
    <dbReference type="SMR" id="Q32IU2"/>
    <dbReference type="STRING" id="300267.SDY_0561"/>
    <dbReference type="EnsemblBacteria" id="ABB60765">
        <property type="protein sequence ID" value="ABB60765"/>
        <property type="gene ID" value="SDY_0561"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0561"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.663"/>
    <dbReference type="HOGENOM" id="CLU_069765_0_0_6"/>
    <dbReference type="OMA" id="IHIGHLI"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000310146" description="Probable nicotinate-nucleotide adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <sequence length="213" mass="24514" checksum="EA2C6689F2400CF5" modified="2005-12-06" version="1">MKSLQALFGGTFDPVHYGHLKPVETLANLIGLTRVTIIPNNVPPHRPQPEANSVQRKHMLELAIADKPLFTLDERELKRNAPSYTAQTLKEWRQEQGPDVPLAFIIGQDSLLTFPTWYEYETILDNAHLIVCRRPGYPLEMAQPQYQQWLEDHLTHNPEDLHLQPAGKIYLAETPWFNISATIIRERLQNGESCDDLLPEPVLTYINQQGLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J08</accession>
    <name>Q32J08_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybdF</name>
        <name evidence="1" type="ordered locus">SDY_0492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000360951.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402188.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J08"/>
    <dbReference type="SMR" id="Q32J08"/>
    <dbReference type="STRING" id="300267.SDY_0492"/>
    <dbReference type="EnsemblBacteria" id="ABB60699">
        <property type="protein sequence ID" value="ABB60699"/>
        <property type="gene ID" value="SDY_0492"/>
    </dbReference>
    <dbReference type="GeneID" id="66671148"/>
    <dbReference type="KEGG" id="sdy:SDY_0492"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.581"/>
    <dbReference type="HOGENOM" id="CLU_105851_1_0_6"/>
    <dbReference type="OMA" id="NKRHWNT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="122" mass="14050" checksum="91C93C810A345A62" modified="2005-12-06" version="1">MDKQSLHETAKRLALELPFVELCWPFGPEFDVFKIGGKIFMLSSELRGVPFINLKSDPQKSLLNQQIYPSIKPGYHMNKKHWISVYPGEEISEALLRDLINDSWNLVVDGLAKRDQKRVRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J47</accession>
    <name>Q32J47_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Primosomal replication protein N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">priC</name>
        <name evidence="1" type="ordered locus">SDY_0452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000844857.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402149.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J47"/>
    <dbReference type="STRING" id="300267.SDY_0452"/>
    <dbReference type="EnsemblBacteria" id="ABB60660">
        <property type="protein sequence ID" value="ABB60660"/>
        <property type="gene ID" value="SDY_0452"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0452"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.535"/>
    <dbReference type="HOGENOM" id="CLU_103284_0_0_6"/>
    <dbReference type="OMA" id="FDRQLFS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038338">
        <property type="entry name" value="PriB/PriC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010890">
        <property type="entry name" value="Primosomal_replicat_PriB/PriC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07445">
        <property type="entry name" value="PriC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="175" mass="20403" checksum="CE851F860C9FEDC6" modified="2005-12-06" version="1">MKTALLLEKLEGQLATLRQRCAPVAQFATLSARFDRHLFQTRATTLQACLDEAGDNLAALRHAVEQQQLPQVAWLAEHLAAQLEAIAREATAWSLREWDSAPPKIARWQRKRIQHQDFERRLREMVTERRARLARVTDLVEQQTLHREVEAYEARLARCRHALEKIENRLARLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J68</accession>
    <name>Q32J68_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_0428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J68"/>
    <dbReference type="STRING" id="300267.SDY_0428"/>
    <dbReference type="EnsemblBacteria" id="ABB60639">
        <property type="protein sequence ID" value="ABB60639"/>
        <property type="gene ID" value="SDY_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0428"/>
    <dbReference type="HOGENOM" id="CLU_163249_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="97" mass="10689" checksum="1537376F0147E39E" modified="2005-12-06" version="1">MAYANWTGARGREEAGLAQSESAHKTRDVYQNEYKLGKRSLNDLLTVEQDVFQAQSAEINANYDGWVAAVNYAAAVNNLIPLAGIKQGLYNDLPDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J84</accession>
    <name>Q32J84_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001001640.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402112.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J84"/>
    <dbReference type="EnsemblBacteria" id="ABB60623">
        <property type="protein sequence ID" value="ABB60623"/>
        <property type="gene ID" value="SDY_0412"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0412"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.489"/>
    <dbReference type="HOGENOM" id="CLU_172421_0_0_6"/>
    <dbReference type="OMA" id="ANRSTIH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="120" mass="14142" checksum="B057EBD8AE78E52D" modified="2005-12-06" version="1">MNEFEKIFNEMNLDRALLPILFRSNRSTVWKYLSGDSTAPASAMSLIMLLQLIQKRNPDLLAEWLTLSDFTIPPEVYLDQPDYWKGWVYTQHKVNKNVLEYLKKHYPDEDQKGMGKTTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JA7</accession>
    <name>Q32JA7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogen regulatory protein P-II 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnK</name>
        <name evidence="5" type="ordered locus">SDY_0387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the P(II) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000780338.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402089.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JA7"/>
    <dbReference type="SMR" id="Q32JA7"/>
    <dbReference type="STRING" id="300267.SDY_0387"/>
    <dbReference type="EnsemblBacteria" id="ABB60600">
        <property type="protein sequence ID" value="ABB60600"/>
        <property type="gene ID" value="SDY_0387"/>
    </dbReference>
    <dbReference type="GeneID" id="67416475"/>
    <dbReference type="KEGG" id="sdy:SDY_0387"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.459"/>
    <dbReference type="HOGENOM" id="CLU_082268_0_0_6"/>
    <dbReference type="OMA" id="YRGTEHV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="12259" checksum="1875CD92C162B537" modified="2005-12-06" version="1">MKLVTVIIKPFKLEDVREALSSIGIQGLTVTEVKGFGRQKGHAELYRGAEYSVNFLPKVKIDVAIADDQLDEVIDIVSKAAYTGKIGDGKIFVAELQRVIRIRTGEADEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JB2</accession>
    <name>Q32JB2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402084.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JB2"/>
    <dbReference type="STRING" id="300267.SDY_0382"/>
    <dbReference type="EnsemblBacteria" id="ABB60595">
        <property type="protein sequence ID" value="ABB60595"/>
        <property type="gene ID" value="SDY_0382"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0382"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.453"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27561" checksum="3E4FE9BF4BF69C4F" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFALTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPLAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JH7</accession>
    <name>Q32JH7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD(P)H-dependent xylose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yajO</name>
        <name evidence="2" type="ordered locus">SDY_0311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001199782.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402019.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JH7"/>
    <dbReference type="STRING" id="300267.SDY_0311"/>
    <dbReference type="EnsemblBacteria" id="ABB60530">
        <property type="protein sequence ID" value="ABB60530"/>
        <property type="gene ID" value="SDY_0311"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0311"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.357"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_6"/>
    <dbReference type="OMA" id="VDLWQVH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="324" mass="36448" checksum="0094EAF9D320FE21" modified="2005-12-06" version="1">MQYNPLGKTDLRVSRLCLGCMTFGEPDRGNHAWTLPEESSRPIIKRALEGGINFFDIANSYSDGSSEEIVGRALRDFSRREDVVVATKVFHRVGDLPEGLSRAQILRSIDDSLRRLGMDYVDILQIHRWDYNTPIEETLEALNDVVKAGKARYIGASSMHASQFAQALELQKQHGWAQFVSMQDHYNLIYREEEREMLPLCYQEGVAVIPWSPLARGRLTRPWGETTARLVSDEVGKNLYKESDENDAQIAERLTGVSEELGATRAQVALAWLLSKPGIAAPIIGTSREEQLDELLNAVDITLKPEQIAELETPYKPHPVVGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JN8</accession>
    <name>Q32JN8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amidase-type enzyme</fullName>
            <ecNumber evidence="3">3.5.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yafV</name>
        <name evidence="3" type="ordered locus">SDY_0245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001118024.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401958.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JN8"/>
    <dbReference type="STRING" id="300267.SDY_0245"/>
    <dbReference type="EnsemblBacteria" id="ABB60469">
        <property type="protein sequence ID" value="ABB60469"/>
        <property type="gene ID" value="SDY_0245"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0245"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.275"/>
    <dbReference type="HOGENOM" id="CLU_030130_3_7_6"/>
    <dbReference type="OMA" id="KIHRFGF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="256" mass="28985" checksum="7F87ED63E8A52729" modified="2005-12-06" version="1">MPGLKITLLQQPLVWMDGPANLRHFDRQLEGITGRDVIVLPEMFTSGFAMEAAASSLAQDDVVNWMTAKAQQCNALIAGSVALQTESGSVNRFLLVEPGGTVHFYDKRHLFRMADEHLHYKAGNARVIVEWRGWRILPLVCYDLRFPVWSRNLNDYDLAIYVANWPAPRSLHWQALLTARAIENQAYVAGCNRFGSDGNGCHYRGDSRVINPQGEIIATADAHQATRIDAELSMAVLREYRDKFPAWRDADEFRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JP1</accession>
    <name>Q32JP1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JP1"/>
    <dbReference type="STRING" id="300267.SDY_0242"/>
    <dbReference type="EnsemblBacteria" id="ABB60466">
        <property type="protein sequence ID" value="ABB60466"/>
        <property type="gene ID" value="SDY_0242"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0242"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="138" mass="16054" checksum="B6EB7A192BA38171" modified="2005-12-06" version="1">MPVAHADVALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JQ4</accession>
    <name>YAFD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0294 protein YafD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yafD</name>
        <name type="ordered locus">SDY_0228</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0294 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001230979.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401942.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JQ4"/>
    <dbReference type="SMR" id="Q32JQ4"/>
    <dbReference type="STRING" id="300267.SDY_0228"/>
    <dbReference type="EnsemblBacteria" id="ABB60453">
        <property type="protein sequence ID" value="ABB60453"/>
        <property type="gene ID" value="SDY_0228"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0228"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.256"/>
    <dbReference type="HOGENOM" id="CLU_083563_0_0_6"/>
    <dbReference type="OMA" id="HAINFSF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01119">
        <property type="entry name" value="UPF0294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022958">
        <property type="entry name" value="UPF0294"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000065255" description="UPF0294 protein YafD">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01119"/>
        </source>
    </evidence>
    <sequence length="266" mass="30006" checksum="1F52CED61FA3E158" modified="2005-12-06" version="1">MRKNTYAMRYVAGQPAERILPPGSFASIGQALPPGEPLSTEERIRILVWNIYKQQRAEWLSVLKNYGKDAHLVLLQEAQTTPELVQFATANYLAADQVPAFVLPQHPSGVMTLSAAHPVYCCPLREREPILRLAKSALVTVYPLPDTRLLMVINIHAVNFSLGVDVYSKQLLPIGDQIAHHSGPVIMAGDFNAWSRRRMNALYRFAREMSLRQVRFTDDQRRRAFGRPLDFVFYRGLNVSEASVLVTRASDHNPLLVEFSPGKPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JU7</accession>
    <name>Q32JU7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="5">3.4.21.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">htrA</name>
        <name evidence="7" type="ordered locus">SDY_0178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.</text>
            <dbReference type="EC" id="3.4.21.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000753949.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401899.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JU7"/>
    <dbReference type="STRING" id="300267.SDY_0178"/>
    <dbReference type="EnsemblBacteria" id="ABB60410">
        <property type="protein sequence ID" value="ABB60410"/>
        <property type="gene ID" value="SDY_0178"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0178"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.207"/>
    <dbReference type="HOGENOM" id="CLU_020120_1_1_6"/>
    <dbReference type="OMA" id="NRSVSMR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="degP_htrA_DO"/>
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    </dbReference>
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        <property type="entry name" value="PDZ"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010598559" description="Periplasmic serine endoprotease DegP-like" evidence="5">
        <location>
            <begin position="27"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="280"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="377"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="474" mass="49343" checksum="22445DAD704A0A44" modified="2005-12-06" version="1">MKKTTLALSALALSLGLALSPLSATAAETSSATTAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDDSPFCQEGSPFQSSPFCQGGQGGNGGGQQQKFMALGSGVIIDADKGYVVTNNHVVDNATVIKVQLSDGRKFDAKMVGKDPRSDIALIQIQNPKNLTAIKMADSDALSVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNAENYENFIQTDAAINRGNSGGALVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEYGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVSQVLPNSSASKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVGSKLTLVLLRDGKQVNVNLELQQSSQNQVDSSSIFNGIEGAEMSNKGKDQGVVVNNVKTGTPAAQIGLKKGDVIIGANQQAVKNIAELRKVLDSKPSVLALNIQRGDSTIYLLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JV5</accession>
    <name>Q32JV5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydroxamate-dependent iron uptake, cytoplasmic membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fhuB</name>
        <name evidence="8" type="ordered locus">SDY_0169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JV5"/>
    <dbReference type="STRING" id="300267.SDY_0169"/>
    <dbReference type="EnsemblBacteria" id="ABB60402">
        <property type="protein sequence ID" value="ABB60402"/>
        <property type="gene ID" value="SDY_0169"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0169"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.195"/>
    <dbReference type="HOGENOM" id="CLU_013016_7_3_6"/>
    <dbReference type="OMA" id="MFPYQIP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="660" mass="70499" checksum="178744BC7AC56611" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JV7</accession>
    <name>Q32JV7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding component of hydroxymate-dependent iron transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fhuC</name>
        <name evidence="5" type="ordered locus">SDY_0167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001158929.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401889.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JV7"/>
    <dbReference type="SMR" id="Q32JV7"/>
    <dbReference type="STRING" id="300267.SDY_0167"/>
    <dbReference type="EnsemblBacteria" id="ABB60400">
        <property type="protein sequence ID" value="ABB60400"/>
        <property type="gene ID" value="SDY_0167"/>
    </dbReference>
    <dbReference type="GeneID" id="67416226"/>
    <dbReference type="KEGG" id="sdy:SDY_0167"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.193"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_6"/>
    <dbReference type="OMA" id="RYAWNGL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="265" mass="28870" checksum="3B0E96ED6D882BA8" modified="2005-12-06" version="1">MQEYTNHSDTTFALRNISFRVPGRTLLHPLSLTFPAGKVTGLIGHNGSGKSTLLKMLGRHQPPSEGEILLDAQPLESWSSKAFARKVAYLPQQLPPAEGMTVRELVAIGRYPWHGALGRFGAADREKVEEAISLVGLKPLAHRLVDSLSGGERQRAWIAMLVAQDSRCLLLDEPTSALDIAHQVDVLALVHRLSQERGLTVIAVLHDINMAARYCDYLVALRGGEMIAQGTPAEIMRGETLEMIYGIPMGILPHPAGAAPVSFVY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K30</accession>
    <name>ARAB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribulokinase</fullName>
            <ecNumber evidence="1">2.7.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">araB</name>
        <name type="ordered locus">SDY_0090</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17601"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17173"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:22072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58226"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribulokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000951876.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401816.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K30"/>
    <dbReference type="SMR" id="Q32K30"/>
    <dbReference type="STRING" id="300267.SDY_0090"/>
    <dbReference type="EnsemblBacteria" id="ABB60327">
        <property type="protein sequence ID" value="ABB60327"/>
        <property type="gene ID" value="SDY_0090"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0090"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.105"/>
    <dbReference type="HOGENOM" id="CLU_009281_9_1_6"/>
    <dbReference type="OMA" id="GHKAMWH"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008741">
        <property type="term" value="F:ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07781">
        <property type="entry name" value="FGGY_RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00520">
        <property type="entry name" value="Ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005929">
        <property type="entry name" value="Ribulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01234">
        <property type="entry name" value="L-ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0054">Arabinose catabolism</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000263405" description="Ribulokinase">
        <location>
            <begin position="1"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00520"/>
        </source>
    </evidence>
    <sequence length="566" mass="61381" checksum="B78B27DA3E63E926" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KA9</accession>
    <name>Q32KA9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mog</name>
        <name evidence="4" type="ordered locus">SDY_0009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020985.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401737.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KA9"/>
    <dbReference type="STRING" id="300267.SDY_0009"/>
    <dbReference type="EnsemblBacteria" id="ABB60249">
        <property type="protein sequence ID" value="ABB60249"/>
        <property type="gene ID" value="SDY_0009"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0009"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.9"/>
    <dbReference type="HOGENOM" id="CLU_077358_1_0_6"/>
    <dbReference type="OMA" id="EYLTSEW"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="195" mass="21238" checksum="37CCEBDB4BE97866" modified="2005-12-06" version="1">MNTLRIGLVSISDRASSGVYQDKGIPALEEWLTSALTTPFELETRLIPDEQAIIEQTLCELVDEMSCHLVLTTGGTGPARRDVTPDATLAVADREMPGFGEQMRQISLHFVPTAILSRQVGVIRKQALILNLPGQPKSIKETLEGVKDAEGNVVVHGIFASVPYCIQLLEGLYVETAPEVVAAFRPKSARRDVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-05-15" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A4SH31</accession>
    <name>A4SH31_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS1294 transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_PA08</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD197_spA</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD197_spA</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000640">
        <property type="protein sequence ID" value="ABO87502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000198563.1">
        <property type="nucleotide sequence ID" value="NC_009344.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001139951.1">
        <property type="nucleotide sequence ID" value="NC_009344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A4SH31"/>
    <dbReference type="EnsemblBacteria" id="ABO87502">
        <property type="protein sequence ID" value="ABO87502"/>
        <property type="gene ID" value="SDY_PA08"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_PA08"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5788"/>
    <dbReference type="HOGENOM" id="CLU_038153_0_0_6"/>
    <dbReference type="OMA" id="LDTQYFH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD197_spA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007069">
        <property type="entry name" value="Transposase_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026889">
        <property type="entry name" value="Zn_Tnp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04986">
        <property type="entry name" value="Y2_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14319">
        <property type="entry name" value="Zn_Tnp_IS91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS91" evidence="1">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABO87502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="402" mass="45934" checksum="65A957D28CA63D76" modified="2007-05-15" version="1">MTRSGGDFQPRPLKRLFTTNQCWTSFLDASGLRDIEVEAVTKMLACGTRILGVKEYNCDKPECPHVRYVTNSCGSRACPSCGKKATDLWIATQLNRLPDCDWVHLVFTLPDTLWPVFESNRWLLNDVCRLAVENLLYAARKRGQEPGIFCAIHTYGRRLNCHPHVHVSVTCGCLNKHGQWKKLSFLKDAMRSRWMWNMRQLLLKAWSEGLAMPESLSHITTESQWRSLVLKAGGKYWHVYMSKKTAGGRNTARYLGRYLKKPPIAASRLAHYNGGASLSFRYLDHKTGETAMETLTQRELVARLKQHIPEKFFKMVRYFGFLANRVCGEKLPQVYRALGMDKPAPVAKVCYAQMVKQFLSRDPFECVLCGGRMVYRRAIAGLNVEGLKKNARDISLLRYMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q326T7</accession>
    <name>Q326T7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISSfl2 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011379003.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406159.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326T7"/>
    <dbReference type="EnsemblBacteria" id="ABB64671">
        <property type="protein sequence ID" value="ABB64671"/>
        <property type="gene ID" value="SDY_P158"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P158"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5714"/>
    <dbReference type="HOGENOM" id="CLU_036902_2_3_6"/>
    <dbReference type="OMA" id="WFFAFLD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="14"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="398" mass="43104" checksum="D314821FAE1FCA9C" modified="2005-12-06" version="1">MTESSDYESVQVFIGVDVGKDTHHAVAINRSGKRLFDKALPNDENKLRSLISDLKQHGQILLVVDQPATIGALPVAVARSEGVLVGYLPGLAMRRIADLHAGEAKTDARDAAIIAEAARTLPHALRTLKLADEQIAELSMLCGFNDDLAAQTTQASNRIRGLLTQIHPALERVLGPRLEHPAVLDLLQRYPSPEKLASLGEKKLAAQLCKLAPRLGKRLAADIAQALAEQTVVVPGTNAAAVVLPRLALQLITLRKQRDEVALEVEQRVLAHPLYPVLTSMPGAGVRTAARLLTEVACRAFASAAHLAAYAGLAPVTRRSGSSIRGEHPSRRGNKALKRALFLSAFAALRDPLSRAYYTRKMSQGKRHNQALIALARRRCDVLFAMMRDGTFYPPQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q326U9</accession>
    <name>Q326U9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS100 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406147.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326U9"/>
    <dbReference type="EnsemblBacteria" id="ABB64659">
        <property type="protein sequence ID" value="ABB64659"/>
        <property type="gene ID" value="SDY_P146"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P146"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5703"/>
    <dbReference type="HOGENOM" id="CLU_062999_1_0_6"/>
    <dbReference type="OMA" id="YLPMDRE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="62"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="220" mass="24868" checksum="29EDB0EEC2BB8904" modified="2005-12-06" version="1">MDFLEHLLHEEKLARHQRKQAMYTRMAAFPAVKTFEEYDFTFATGAPQKQLQSLRSLSFIERNENIVLLGPSGVGKTHLAIAMGYEAVRAGIKVRFTTAADLLLQLSTAQRQGRYKTTLQRGVMAPRLLIIDEIGYLPFSQEEAKLFFQVIAKRYEKSAMILTSNLPFGQWDQTFAGDAALTSAMLGRILHHSHVVQIKGESYRLRQKRKAGVIAEANPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Y6</accession>
    <name>Q326Y6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VirK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">virK</name>
        <name evidence="1" type="ordered locus">SDY_P109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004970430.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406110.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Y6"/>
    <dbReference type="EnsemblBacteria" id="ABB64622">
        <property type="protein sequence ID" value="ABB64622"/>
        <property type="gene ID" value="SDY_P109"/>
    </dbReference>
    <dbReference type="GeneID" id="58462861"/>
    <dbReference type="KEGG" id="sdy:SDY_P109"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5664"/>
    <dbReference type="HOGENOM" id="CLU_065818_1_0_6"/>
    <dbReference type="OMA" id="SPFQEEG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007488">
        <property type="entry name" value="DUF535"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38785">
        <property type="entry name" value="PTHR38785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04393">
        <property type="entry name" value="DUF535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="316" mass="36667" checksum="8BEAACA4E3D65E83" modified="2005-12-06" version="1">MFSVSNLSFIGFLKRIVFSSDSLPGKWEHRKFRFMYILRCAINPVASIRYYYELRSLQCIEDILAIQPTLPARIHRPYLHKGGRAWSRGQYILEHYRFVQNLPEKYSEFLFPQKSVSLVQFIGKDGEDFDIQCSPSGFDREGELMLSLFFNKIVIARLTFSVILTQNGHTAFIGGLQGAPKNTGPDVIRCATRACYGLFPKRIIFEAFCALMKACNVSECLAVSEHSHVFRQLRYWYQKRKTFVAVYSDFWESVAGKTCGDWYKLPTQVVRKPLSNIASKKRSEYRKRYALLDYIHETAIRSLDAYPVNSEHQDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q327E4</accession>
    <name>Q327E4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS629 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406052.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327E4"/>
    <dbReference type="EnsemblBacteria" id="ABB64564">
        <property type="protein sequence ID" value="ABB64564"/>
        <property type="gene ID" value="SDY_P051"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P051"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5595"/>
    <dbReference type="HOGENOM" id="CLU_027402_41_1_6"/>
    <dbReference type="OMA" id="KKINKVW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="44"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="215" mass="23954" checksum="C14D5A8DCCCC8BF4" modified="2005-12-06" version="1">MARCTVARLMAVMGLAGVLRGKKVRTTISRKAVAAGDRVNRQFVAERPDQLRVADFTYASTWQGFVYVAFIIDVFAGYIVGWRVSSSMETTFVLDALEQALWARRPSGTVHHSDKGSQYVSLAYTQRLKEAGLLASTGSTGDSYDNAMAESINGLYKAEVIHRKSWKNRAEVELAILTWVDWYNNRRLLERLGYTPPAEAEKAYYASIGNDDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q327F5</accession>
    <name>Q327F5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406041.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327F5"/>
    <dbReference type="EnsemblBacteria" id="ABB64553">
        <property type="protein sequence ID" value="ABB64553"/>
        <property type="gene ID" value="SDY_P040"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P040"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5584"/>
    <dbReference type="HOGENOM" id="CLU_1730152_0_0_6"/>
    <dbReference type="OMA" id="WIQHEPS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="151" mass="17540" checksum="87F66CDDC19355E4" modified="2005-12-06" version="1">MCQVFGVSRSGYYNWIQHEPSDRKQSDERLKLEIKVAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNSCAKSAEPDVRSYSTKSGLGGGPDVCCHTGGMVVPRWHQRCLYVRNCRLRHGRAHDKRADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q327G6</accession>
    <name>Q327G6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">IS100 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_P029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Sd197</strain>
            <plasmid evidence="10">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase IS21/IS408/IS1162 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406030.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327G6"/>
    <dbReference type="EnsemblBacteria" id="ABB64542">
        <property type="protein sequence ID" value="ABB64542"/>
        <property type="gene ID" value="SDY_P029"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P029"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5566"/>
    <dbReference type="HOGENOM" id="CLU_020626_4_0_6"/>
    <dbReference type="OMA" id="FINCHIN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="90"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="362" mass="41568" checksum="9B08E02DF42CE8E7" modified="2005-12-06" version="1">MPDSRNTVKRYLQAKSEPPKYTPRPAVASLLDEYRDYIRQRIADAHPYKIPATVIAREIRDQGYRGGMTILRAFIRSLSVPQEQEPAVRFETEPGRQMQVDWGTMRNGRSPLHVFVAVPGYSRMLYIEFTDNMRYDTLETCHRNAFRFFGGVPREVLYDNMKTVVLQRDAYQTGQHRFHPSLWQFGKEMGFSPRLCRPFRAQTKGKVERMVQYTRNSFYIPLMTRLRPMGSTVDVETANRHGLRWLHDVANQRKHETIQARPCDRWLEEQQSMLALPPEKKEYDVHPGENLVSFDNPPNIIHSPSTTHSAEEWRDDGTATSTTDGARRAVATGKPYKRSACAVTTGSRPGMELYGLPGASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q327P7</accession>
    <name>Q327P7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000181149.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405949.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327P7"/>
    <dbReference type="EnsemblBacteria" id="ABB64458">
        <property type="protein sequence ID" value="ABB64458"/>
        <property type="gene ID" value="SDY_4600"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4600"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5451"/>
    <dbReference type="HOGENOM" id="CLU_059548_1_0_6"/>
    <dbReference type="OMA" id="TRRMPHH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="2">
        <location>
            <begin position="8"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="314" mass="36734" checksum="8D7EE7A220BBA02F" modified="2005-12-06" version="1">MTNFTTSTPHDALFKSFLTHPDTAQDFMEIHLPKDLRELCDLDTLKLESASFVDEKLRALHSDILWSVETREGDGYIYVVIEHQSREDIHMAFRLMRYSMAVMQRHIEHDKRRPLPLVIPMLFYHGSRSPYPWSLCWLDEFADPTTARKLYTAAFPLVDVTVVPDDEIVQHRRVALLELIQKHIRQHDLMGLIDQLVVLLVTECANDSQITALLNYILLTGDEARFNEFISELTRRMPQHRERIMTIAERIHNDGWLLGREKGKEEGEQRLLRLLLQNGADPEWIQKITGLSAEQMQALEQPLPESKREPWIEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q328F0</accession>
    <name>MIAA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="1">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="1">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="1">IPP transferase</shortName>
            <shortName evidence="1">IPPT</shortName>
            <shortName evidence="1">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaA</name>
        <name type="ordered locus">SDY_4418</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001280343.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405796.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328F0"/>
    <dbReference type="SMR" id="Q328F0"/>
    <dbReference type="STRING" id="300267.SDY_4418"/>
    <dbReference type="EnsemblBacteria" id="ABB64305">
        <property type="protein sequence ID" value="ABB64305"/>
        <property type="gene ID" value="SDY_4418"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4418"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5216"/>
    <dbReference type="HOGENOM" id="CLU_032616_0_0_6"/>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000020659" description="tRNA dimethylallyltransferase">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="166"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="247"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="280"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <sequence length="316" mass="35022" checksum="7D306187707804F6" modified="2005-12-06" version="1">MSDISKASLPKAIFLMGPTASGKTALAIELRKILPVELISVDSALIYKGMDIGTAKPNAEELLAAPHRLLDIRDPSQAYSAADFRRDALAEMADITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRARIEQQAAEQGWESLHRQLQEVDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIEQRFHQMLASGFEAEVRALFARGDLHTDLPSIRCVGYRQMWSYLEGEISYDEMVYLGVCATRQLAKRQITWLRGWEGVHWLDSEKPEQARDEVLQVVGAIAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q328F1</accession>
    <name>HFQ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein Hfq</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hfq</name>
        <name type="ordered locus">SDY_4417</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Hfq family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001051884.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405795.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328F1"/>
    <dbReference type="SMR" id="Q328F1"/>
    <dbReference type="STRING" id="300267.SDY_4417"/>
    <dbReference type="EnsemblBacteria" id="ABB64304">
        <property type="protein sequence ID" value="ABB64304"/>
        <property type="gene ID" value="SDY_4417"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4417"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5215"/>
    <dbReference type="HOGENOM" id="CLU_113688_2_1_6"/>
    <dbReference type="OMA" id="QQMVYKH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01716">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00436">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005001">
        <property type="entry name" value="Hfq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34772">
        <property type="entry name" value="PTHR34772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17209">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02383">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000265192" description="RNA-binding protein Hfq">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="102" mass="11192" checksum="E47FA9B07A2C254D" modified="2005-12-06" version="1">MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQIESFDQFVILLKNTVSQMVYKHAISTVVPSRPVSHHSNNAGGGTSSNYHHGSSPQNTSAQQDSEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q328S6</accession>
    <name>Q328S6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328S6"/>
    <dbReference type="STRING" id="300267.SDY_4278"/>
    <dbReference type="EnsemblBacteria" id="ABB64179">
        <property type="protein sequence ID" value="ABB64179"/>
        <property type="gene ID" value="SDY_4278"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4278"/>
    <dbReference type="HOGENOM" id="CLU_183084_0_0_6"/>
    <dbReference type="OMA" id="GHIDCEV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="97" mass="10759" checksum="BA88DCD978E7CF93" modified="2005-12-06" version="1">MVGSGGIAPLAGSESDICELQKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAFLKEAIALYEHLGFEHIDYALGCTGHVDCEVRMLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q328T6</accession>
    <name>Q328T6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405660.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328T6"/>
    <dbReference type="EnsemblBacteria" id="ABB64169">
        <property type="protein sequence ID" value="ABB64169"/>
        <property type="gene ID" value="SDY_4268"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4268"/>
    <dbReference type="HOGENOM" id="CLU_3103780_0_0_6"/>
    <dbReference type="OMA" id="FFVMIVR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="54" mass="6295" checksum="AEAD2F3050F84686" modified="2005-12-06" version="1">MLSVLLKLLIILVLTPRASTWLLAIRLGYLAVYSMNMSVRKLFRLPIFFVMIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q328W8</accession>
    <name>Q328W8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328W8"/>
    <dbReference type="EnsemblBacteria" id="ABB64137">
        <property type="protein sequence ID" value="ABB64137"/>
        <property type="gene ID" value="SDY_4236"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4236"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="9392" checksum="50D7A86AC97FD450" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITDVTCARGILHYGNNYYLQITSDPLLAILFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q329N9</accession>
    <name>Q329N9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yibD</name>
        <name evidence="2" type="ordered locus">SDY_4048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000982116.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405457.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329N9"/>
    <dbReference type="STRING" id="300267.SDY_4048"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63966">
        <property type="protein sequence ID" value="ABB63966"/>
        <property type="gene ID" value="SDY_4048"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4048"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4764"/>
    <dbReference type="HOGENOM" id="CLU_025996_25_4_6"/>
    <dbReference type="OMA" id="QDIPWTT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="334" mass="39216" checksum="FD3D29FBA8607554" modified="2005-12-06" version="1">MMNSTNKLSVIIPLYNAGDDFRTCMESLITQTWTALEIIIINDGSTDNSVEIAKYYAENYPHVRLLHQANAGASVARNRGIEVATGKYVAFVDADDEVYPTMYETLMTMALEDDLDVAQCNADWCFRETGETWQSIPTDRLRSTGVLTGPDWLRMGLSSRRWTHVVWMGVYRRDVIVKNNIKFIAGLHHQDIVWTTEFMFNALRARYTEQSLYKYYLHNTSVSRLHRQGNKNLNYQRHYIKITRLLEKLNRNYADKITIYPEFHQQITYEALRVCHAVRKEPDILTRQRMIAEIFTSGMYKRLITNVRSVKVGYQALLWSFRLWQWRDKPSHYA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q329R9</accession>
    <name>GLMU_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="1">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="1">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmU</name>
        <name type="ordered locus">SDY_4018</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="1"/>
    <dbReference type="EC" id="2.3.1.157" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000933753.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405427.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329R9"/>
    <dbReference type="SMR" id="Q329R9"/>
    <dbReference type="STRING" id="300267.SDY_4018"/>
    <dbReference type="EnsemblBacteria" id="ABB63936">
        <property type="protein sequence ID" value="ABB63936"/>
        <property type="gene ID" value="SDY_4018"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4018"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4731"/>
    <dbReference type="HOGENOM" id="CLU_029499_15_2_6"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00533"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000233841" description="Bifunctional protein GlmU">
        <location>
            <begin position="1"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="251"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="103"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="386"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <sequence length="456" mass="49218" checksum="B080CC4FBB888B88" modified="2005-12-06" version="1">MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDARPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A17</accession>
    <name>Q32A17_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription antitermination protein RfaH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rfaH</name>
        <name evidence="6" type="ordered locus">SDY_3903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RfaH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001192396.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405329.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A17"/>
    <dbReference type="SMR" id="Q32A17"/>
    <dbReference type="STRING" id="300267.SDY_3903"/>
    <dbReference type="EnsemblBacteria" id="ABB63838">
        <property type="protein sequence ID" value="ABB63838"/>
        <property type="gene ID" value="SDY_3903"/>
    </dbReference>
    <dbReference type="GeneID" id="66672252"/>
    <dbReference type="KEGG" id="sdy:SDY_3903"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4611"/>
    <dbReference type="HOGENOM" id="CLU_067287_5_0_6"/>
    <dbReference type="OMA" id="NQGVECF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001073">
        <property type="term" value="F:transcription antitermination factor activity, DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00951">
        <property type="entry name" value="RfaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010215">
        <property type="entry name" value="Transcription_antiterm_RfaH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01955">
        <property type="entry name" value="RfaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="162" mass="18340" checksum="2A298947EBB58C65" modified="2005-12-06" version="1">MQSWYLLYCKRGQLQRAQEHLERQAVNCLAPMITLEKIVRGKRTAVSEPLFPNYLFVEFDPEVIHTTTINATRGVSHFVRFGASPAIVPSAVIHQLSVYKPKDIVDPATPYPGDKVIITEGAFEGFQAIFTEPDGEARSMLLLNLINKEIKHSVKNTEFRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A62</accession>
    <name>Q32A62_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Formate dehydrogenase, cytochrome B556 (FDO) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fdoI</name>
        <name evidence="11" type="ordered locus">SDY_3851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the formate dehydrogenase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000829013.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405284.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A62"/>
    <dbReference type="SMR" id="Q32A62"/>
    <dbReference type="STRING" id="300267.SDY_3851"/>
    <dbReference type="EnsemblBacteria" id="ABB63793">
        <property type="protein sequence ID" value="ABB63793"/>
        <property type="gene ID" value="SDY_3851"/>
    </dbReference>
    <dbReference type="GeneID" id="66672199"/>
    <dbReference type="KEGG" id="sdy:SDY_3851"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4550"/>
    <dbReference type="HOGENOM" id="CLU_091368_1_1_6"/>
    <dbReference type="OMA" id="DIVWAKN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009326">
        <property type="term" value="C:formate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006471">
        <property type="entry name" value="Formate_DH_gsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01583">
        <property type="entry name" value="formate-DH-gamm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="10">
        <location>
            <begin position="9"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="211" mass="24606" checksum="166AC5A661C738D5" modified="2005-12-06" version="1">MKRRDTIVRYTAPERINHWITAFCFILAAVSGLGFLFPSFNWLMQIMGTPQLARILHPFVGVVMFASFIIMFFRYWHHNLINRDDIFWAKNIRKIVVNEEVGDTGRYNFGQKCVFWAAIIFLVLLLVSGVIIWRPYFAPAFSIPVIRFALMLHSFAAVALIVVIMVHIYAALWVKGTITAMVEGWVTSAWAKKHHPRWYREVRKTTEKKAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AE8</accession>
    <name>MURB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="1">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murB</name>
        <name type="ordered locus">SDY_3756</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001016672.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405198.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AE8"/>
    <dbReference type="SMR" id="Q32AE8"/>
    <dbReference type="STRING" id="300267.SDY_3756"/>
    <dbReference type="EnsemblBacteria" id="ABB63707">
        <property type="protein sequence ID" value="ABB63707"/>
        <property type="gene ID" value="SDY_3756"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3756"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4447"/>
    <dbReference type="HOGENOM" id="CLU_035304_0_0_6"/>
    <dbReference type="OMA" id="MQNIGAY"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000224719" description="UDP-N-acetylenolpyruvoylglucosamine reductase">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <sequence length="342" mass="37873" checksum="A1E69F2E3140ADEF" modified="2005-12-06" version="1">MNHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQHATAEGQPVLILGEGSNVLFLEDYRGTVIINRIKGIEIHDEPDAWYLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGAYGVELQRVCAYVDCVELATGKQVRLTAKECRFGYRDSIFKHEYQDRFAIVAVGLRLPKEWQPVLTYGDLTRLEPTTVTPQQVFNAVCHMRTTKLPDPKVNGNAGSFFKNPVVSAETAKALLSQFPTAPNYPQADGSVKLAAGWLIDQCQLKGMQMGGAAVHRQQALVLINEDNAKSEDVVQLAHHVRQKVGEKFNVWLEPEVRFIGASGEVSAVETIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AH0</accession>
    <name>DCUP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="1">UPD</shortName>
            <shortName evidence="1">URO-D</shortName>
            <ecNumber evidence="1">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemE</name>
        <name type="ordered locus">SDY_3729</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000137655.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405176.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AH0"/>
    <dbReference type="SMR" id="Q32AH0"/>
    <dbReference type="STRING" id="300267.SDY_3729"/>
    <dbReference type="EnsemblBacteria" id="ABB63685">
        <property type="protein sequence ID" value="ABB63685"/>
        <property type="gene ID" value="SDY_3729"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3729"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4421"/>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_6"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000023978" description="Uroporphyrinogen decarboxylase">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="27"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <sequence length="354" mass="39264" checksum="604933D101C0260C" modified="2005-12-06" version="1">MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILTVPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDGRRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPPARIEEEVATILAGFGHGEGHVFNLGHGIHQDVPLEHAGVFVEAVHRLSEQYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AH7</accession>
    <name>Q32AH7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sensor HydH response regulator of hydrogenase 3 activity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hydG</name>
        <name evidence="10" type="ordered locus">SDY_3722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000148492.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405169.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AH7"/>
    <dbReference type="STRING" id="300267.SDY_3722"/>
    <dbReference type="EnsemblBacteria" id="ABB63678">
        <property type="protein sequence ID" value="ABB63678"/>
        <property type="gene ID" value="SDY_3722"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3722"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4413"/>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_6"/>
    <dbReference type="OMA" id="MPISMQV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="8">
        <location>
            <begin position="141"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="441" mass="48426" checksum="5A8E684B808907AB" modified="2005-12-06" version="1">MTHDNIDILVVDDDISHCTILQALLRGWGYNVALANSERQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALKPAIPVLIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSIDAETPAVTASQFGMVGKSPAMQHLLSEIALVAPSEATVLIHGDSGTGKELVARAIHASSARSEKPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGHFVEADGGTLFLDEIGDISPMMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAAEANAGRFRQDLYYRLNVVAIEVPSLRQRREDIPLLAGHFFQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAVERAVVLLTGEYISERELPLAIAGTPIPLGQSQDIQPLVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AL2</accession>
    <name>Q32AL2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heat shock protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yrfH</name>
        <name evidence="6" type="ordered locus">SDY_3678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HSP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000660483.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405134.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AL2"/>
    <dbReference type="SMR" id="Q32AL2"/>
    <dbReference type="STRING" id="300267.SDY_3678"/>
    <dbReference type="EnsemblBacteria" id="ABB63643">
        <property type="protein sequence ID" value="ABB63643"/>
        <property type="gene ID" value="SDY_3678"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3678"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4365"/>
    <dbReference type="HOGENOM" id="CLU_101003_2_1_6"/>
    <dbReference type="OMA" id="IDKYLWC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025708">
        <property type="entry name" value="HSP15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016821">
        <property type="entry name" value="HSP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="133" mass="15496" checksum="4B3D40FAECC42D5B" modified="2005-12-06" version="1">MKEKPAVEVRLDKWLWAARFYKTRALAREMIEGGKVHYNGQRSKPSKIVELNATLTLRQGNDERTVIVKAITEQRRPASEAALLYEETAESVEKREKMALARKLNALTMPHPDRRPDKKERRDLLRFKHGDSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AT5</accession>
    <name>UGPE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>sn-glycerol-3-phosphate transport system permease protein UgpE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ugpE</name>
        <name type="ordered locus">SDY_3599</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000572161.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405061.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AT5"/>
    <dbReference type="SMR" id="Q32AT5"/>
    <dbReference type="STRING" id="300267.SDY_3599"/>
    <dbReference type="EnsemblBacteria" id="ABB63570">
        <property type="protein sequence ID" value="ABB63570"/>
        <property type="gene ID" value="SDY_3599"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3599"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4274"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_6"/>
    <dbReference type="OMA" id="IAFFIAW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055052">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015794">
        <property type="term" value="P:glycerol-3-phosphate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001407">
        <property type="term" value="P:glycerophosphodiester transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030165">
        <property type="entry name" value="UgpE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43744:SF8">
        <property type="entry name" value="PTHR43744:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000292685" description="sn-glycerol-3-phosphate transport system permease protein UgpE">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="2">
        <location>
            <begin position="77"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="281" mass="31484" checksum="ECA7713CBF88F5B2" modified="2005-12-06" version="1">MIENRPWLTIFSHTMLILGIAVILFPLYVAFVAATLDKQAVYAAPMTLIPGTHLLENIHNIWVNGVGTNSAPFWRMLLNSFVMAFSITLGKITVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASATATFLFRQFFMILPDELVEAARIDGASPMRFFCDIVFPLSKTNLAALFVITFIYGWNQYLWPLLIITDVDLGTTVAGIKGMIATGEGTTEWNSVMAAMLLTLIPPVVIVLVMQRAFVRGLVDSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AX7</accession>
    <name>Q32AX7_SHIDS</name>
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        <submittedName>
            <fullName evidence="10">Outer membrane heme/hemoglobin receptor</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="primary">shuA</name>
        <name evidence="10" type="ordered locus">SDY_3554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
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            <taxon>Gammaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220981" evidence="7">
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            <end position="660"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="658"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="660" mass="72529" checksum="E4776B9BEA31A165" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B13</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000634792.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404983.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B13"/>
    <dbReference type="STRING" id="300267.SDY_3514"/>
    <dbReference type="EnsemblBacteria" id="ABB63492">
        <property type="protein sequence ID" value="ABB63492"/>
        <property type="gene ID" value="SDY_3514"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3514"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4168"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_6"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="313"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="345"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="637" mass="71814" checksum="F6A0F4CFD55B32D1" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B24</accession>
    <name>RS12_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsL</name>
        <name type="ordered locus">SDY_3503</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000246815.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404972.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B24"/>
    <dbReference type="SMR" id="Q32B24"/>
    <dbReference type="STRING" id="300267.SDY_3503"/>
    <dbReference type="EnsemblBacteria" id="ABB63481">
        <property type="protein sequence ID" value="ABB63481"/>
        <property type="gene ID" value="SDY_3503"/>
    </dbReference>
    <dbReference type="GeneID" id="64727495"/>
    <dbReference type="GeneID" id="67463992"/>
    <dbReference type="KEGG" id="sdy:SDY_3503"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4157"/>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_6"/>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="PRO" id="PR:Q32B24"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000226414" description="30S ribosomal protein S12">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-methylthioaspartic acid" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <sequence length="124" mass="13737" checksum="94A57F4C4FF0FC5E" modified="2005-12-06" version="1">MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKRPKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B47</accession>
    <name>RL18_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplR</name>
        <name type="ordered locus">SDY_3480</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000358960.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404949.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B47"/>
    <dbReference type="SMR" id="Q32B47"/>
    <dbReference type="STRING" id="300267.SDY_3480"/>
    <dbReference type="EnsemblBacteria" id="ABB63458">
        <property type="protein sequence ID" value="ABB63458"/>
        <property type="gene ID" value="SDY_3480"/>
    </dbReference>
    <dbReference type="GeneID" id="64338599"/>
    <dbReference type="GeneID" id="67515065"/>
    <dbReference type="KEGG" id="sdy:SDY_3480"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4133"/>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_6"/>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000251368" description="50S ribosomal protein L18">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <sequence length="117" mass="12770" checksum="CA1082FF9B5D9697" modified="2005-12-06" version="1">MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B88</accession>
    <name>Q32B88_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
            <ecNumber evidence="2">2.7.7.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhdA</name>
        <name evidence="6" type="ordered locus">SDY_3427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24898"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="2.7.7.65"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001241386.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404908.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B88"/>
    <dbReference type="STRING" id="300267.SDY_3427"/>
    <dbReference type="EnsemblBacteria" id="ABB63417">
        <property type="protein sequence ID" value="ABB63417"/>
        <property type="gene ID" value="SDY_3427"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3427"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4085"/>
    <dbReference type="HOGENOM" id="CLU_028330_0_0_6"/>
    <dbReference type="OMA" id="CQYIGRL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033423">
        <property type="entry name" value="GAPES4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17157">
        <property type="entry name" value="GAPES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="254"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="396"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="646" mass="73228" checksum="21A1CDE3A44BCE28" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BE3</accession>
    <name>Q32BE3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yrbA</name>
        <name evidence="4" type="ordered locus">SDY_3371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404853.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BE3"/>
    <dbReference type="SMR" id="Q32BE3"/>
    <dbReference type="STRING" id="300267.SDY_3371"/>
    <dbReference type="EnsemblBacteria" id="ABB63362">
        <property type="protein sequence ID" value="ABB63362"/>
        <property type="gene ID" value="SDY_3371"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3371"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4025"/>
    <dbReference type="HOGENOM" id="CLU_109462_4_1_6"/>
    <dbReference type="OMA" id="QIYAHLN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="SSF82657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="89" mass="10037" checksum="3916DF65F11BDE9A" modified="2005-12-06" version="1">MIEDPMENNEIQSVLMNALSLQEVHVSGDGSHFQVIAVGELFDGMSRVKKQQTVYGPLMEYIADNRIHAVSIKAYTPAEWARDRKLNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BK7</accession>
    <name>Q32BK7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhaO</name>
        <name evidence="2" type="ordered locus">SDY_3301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000401566.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404789.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BK7"/>
    <dbReference type="STRING" id="300267.SDY_3301"/>
    <dbReference type="EnsemblBacteria" id="ABB63298">
        <property type="protein sequence ID" value="ABB63298"/>
        <property type="gene ID" value="SDY_3301"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3301"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3946"/>
    <dbReference type="HOGENOM" id="CLU_052043_3_0_6"/>
    <dbReference type="OMA" id="FPGSWAT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="443" mass="48387" checksum="E3401ACB298B0907" modified="2005-12-06" version="1">MEIASNKGVIADASTPAGRAGMSESEWREAIKFDSTDTGWVIMSIGMAIGAGIIFLPVQVGLMGLWVFLLSSVIGYPAMYLFQRLFINTLAESPECKDYPSVISGYLGKNWGILLGALYFVMLVIWMFVYSTAITNDSASYLHTFGVTEGLLSDSPFYGLVLICILVAISSRGEKLLFKISTGMVLTKLLVVAALGVSMVGMWHLYNVGSLPPLGLLVKNAIITLPFTLTSILFIQTLSPMVISYRSREKSIEVARHKVLRAMNIAFGILFVTVFFYAVSFTLAMGHDEAVKAYEQNISALAIAAQFISGDGAAWVKVVSVILNIFAVMTAFFSVYLGFREATQGIVMNILRRKMPAEKINENLVQRGIMIFAILLAWSAIVLNAPVLSFTSICSPIFGMVGCLIPAWLVYKVPALHKYKGMSLYLIIVTGLLLCVSPFLAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BN1</accession>
    <name>Q32BN1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygjV</name>
        <name evidence="2" type="ordered locus">SDY_3275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404765.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BN1"/>
    <dbReference type="STRING" id="300267.SDY_3275"/>
    <dbReference type="EnsemblBacteria" id="ABB63274">
        <property type="protein sequence ID" value="ABB63274"/>
        <property type="gene ID" value="SDY_3275"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3275"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3916"/>
    <dbReference type="HOGENOM" id="CLU_107941_0_0_6"/>
    <dbReference type="OMA" id="LFNSFCW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019629">
        <property type="entry name" value="Uncharacterised_HI1736/YgjV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026267">
        <property type="entry name" value="YgjV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10688">
        <property type="entry name" value="Imp-YgjV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011443">
        <property type="entry name" value="YgjV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="179" mass="20038" checksum="CFB9CC0EC959ABB8" modified="2005-12-06" version="1">MAGPGRGVIAFLIGITTFFNRDERRFKKQLSVYSAVIGVHFFLLGTYPAGASAILNAIRTLITLRTRSLWVMAIFIVLTGGIGLAKFHHPVELLPVIGTIVSTWALFRCKGLTMRCVMWFSTCCWVIHNFWAGSIGGTMIEGSFLLMNGLNIIRFWRMQKRGIDPFKVEKTPPAIDERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BU1</accession>
    <name>Q32BU1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Outer membrane channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tolC</name>
        <name evidence="6" type="ordered locus">SDY_3205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BU1"/>
    <dbReference type="STRING" id="300267.SDY_3205"/>
    <dbReference type="EnsemblBacteria" id="ABB63214">
        <property type="protein sequence ID" value="ABB63214"/>
        <property type="gene ID" value="SDY_3205"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3205"/>
    <dbReference type="HOGENOM" id="CLU_012817_0_2_6"/>
    <dbReference type="OMA" id="YNAKQQL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010130">
        <property type="entry name" value="T1SS_OMP_TolC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01844">
        <property type="entry name" value="type_I_sec_TolC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220996" evidence="5">
        <location>
            <begin position="25"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="495" mass="54012" checksum="283A626B2BA32D9E" modified="2005-12-06" version="1">MQMKKLLPILIGLSLSGFSSLSQAENLMQVYQQARLNNPELRKSAADRDAAFEKINEARSPLLPQLGLGADYTYSNGYRDANGINSNATSASLQLTQSIFDMSKWRALTLLEKAAGIQDVTYQTDQQTLILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDVQNARAQYDTVLANEVTARNNLDNAVEQLRQITGNYYPELAALNVENFKTDKPQPVNALLKEAEKRNLSLLQARLSQDLAREQIRQAQDGHLPTLDLTASTGISDTSYSGSKTRGAAGTQYDDSNMGQNKVGLSFSLPIYQGGMVNSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTTLYNAKQELANARYNYLINQLNIKSALGTLNEQDLLALNNALSKPVSTNPENVAPQTPEQNAIADGYAPDSPAPVVQQTSARTTTSNGHNPFRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BV3</accession>
    <name>SYK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="1">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lysS</name>
        <name type="ordered locus">SDY_3192</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000003082.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404693.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BV3"/>
    <dbReference type="SMR" id="Q32BV3"/>
    <dbReference type="STRING" id="300267.SDY_3192"/>
    <dbReference type="PRIDE" id="Q32BV3"/>
    <dbReference type="EnsemblBacteria" id="ABB63202">
        <property type="protein sequence ID" value="ABB63202"/>
        <property type="gene ID" value="SDY_3192"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3192"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3814"/>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_6"/>
    <dbReference type="OMA" id="EIFGEKC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000012936" description="Lysine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <sequence length="505" mass="57632" checksum="48FCF88E37B52AE0" modified="2005-12-06" version="1">MSEQHAQGADAVVDLNNELKTRREKLANLREQGIAFPNDFRRDHTSDQLHTEFDGKENEELEALNIEVAVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDDLPEGVYNEQFKKWDLGDILGAKGKLFKTKTGELSIHCTELRLLTKALRPLPDKFHGLQDQEARYRQRYLDLISNDESRNTFKVRSQILSGIRQFMVNRGFMEVETPMMQVIPGGAAARPFITHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYKDLIELTESLFRTLAQNILGKTEVTYGDVTLDFGKPFEKLTMREAIKKYRPETDMADLDNFDSAKAIAESIGIHVEKSWGLGRIVTEIFEEVAEAHLIQPTFITEYPAEVSPLARRNDVNPEITDRFEFFIGGREIGNGFSELNDAEDQAQRFLDQVAAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BY3</accession>
    <name>Q32BY3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Arginine exporter protein ArgO</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yggA</name>
        <name evidence="10" type="synonym">argO</name>
        <name evidence="11" type="ordered locus">SDY_3159</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell inner membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the LysE/ArgO transporter (TC 2.A.75) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000493346.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404663.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BY3"/>
    <dbReference type="STRING" id="300267.SDY_3159"/>
    <dbReference type="EnsemblBacteria" id="ABB63172">
        <property type="protein sequence ID" value="ABB63172"/>
        <property type="gene ID" value="SDY_3159"/>
    </dbReference>
    <dbReference type="GeneID" id="58460585"/>
    <dbReference type="KEGG" id="sdy:SDY_3159"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3772"/>
    <dbReference type="HOGENOM" id="CLU_087840_0_1_6"/>
    <dbReference type="OMA" id="FARPRAW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01901">
        <property type="entry name" value="ArgO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023445">
        <property type="entry name" value="Arg_export_ArgO_enterobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004777">
        <property type="entry name" value="Lys/arg_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00948">
        <property type="entry name" value="2a75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="211" mass="23174" checksum="5F22D06A3A8FBD73" modified="2005-12-06" version="1">MFSYYFQGLALGAAMILPLGPQNAFVMNQGIRRQYHIMIALLCAISDLVLICAGIFGGSALLMQSPWLLALVTWGGVAFLLWYGFGAFKTAMSSNIELASAEVLKQGRWKIIATMLAVTWLNPHVYLDTFVVLGSLGGQLDVEPKRWFALGTISASFLWFFGLAILAAWLAPRLRTAKSQRIINLVVGCVMWFIALQLARDGIAHAQALFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BY7</accession>
    <name>E4PD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-erythrose-4-phosphate dehydrogenase</fullName>
            <shortName evidence="2">E4PDH</shortName>
            <ecNumber evidence="2">1.2.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">epd</name>
        <name type="ordered locus">SDY_3155</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-erythrose 4-phosphate + H2O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58766"/>
            <dbReference type="EC" id="1.2.1.72"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000218474.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404659.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BY7"/>
    <dbReference type="SMR" id="Q32BY7"/>
    <dbReference type="STRING" id="300267.SDY_3155"/>
    <dbReference type="EnsemblBacteria" id="ABB63168">
        <property type="protein sequence ID" value="ABB63168"/>
        <property type="gene ID" value="SDY_3155"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3155"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3768"/>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_6"/>
    <dbReference type="OMA" id="NAKVLAW"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048001">
        <property type="term" value="F:erythrose-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01640">
        <property type="entry name" value="E4P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006422">
        <property type="entry name" value="E4P_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01532">
        <property type="entry name" value="E4PD_g-proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000293170" description="D-erythrose-4-phosphate dehydrogenase">
        <location>
            <begin position="2"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01640"/>
        </source>
    </evidence>
    <sequence length="339" mass="37313" checksum="46CF5942267EB032" modified="2005-12-06" version="1">MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHERSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPIDTKLAAGITRFFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMATVAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C07</accession>
    <name>Q32C07_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Biosynthetic arginine decarboxylase</fullName>
            <shortName evidence="12">ADC</shortName>
            <ecNumber evidence="12">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">speA</name>
        <name evidence="17" type="ordered locus">SDY_3134</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Catalyzes the biosynthesis of agmatine from arginine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295380.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404639.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C07"/>
    <dbReference type="SMR" id="Q32C07"/>
    <dbReference type="STRING" id="300267.SDY_3134"/>
    <dbReference type="EnsemblBacteria" id="ABB63148">
        <property type="protein sequence ID" value="ABB63148"/>
        <property type="gene ID" value="SDY_3134"/>
    </dbReference>
    <dbReference type="GeneID" id="66673180"/>
    <dbReference type="KEGG" id="sdy:SDY_3134"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3743"/>
    <dbReference type="HOGENOM" id="CLU_027243_1_0_6"/>
    <dbReference type="OMA" id="AVEYTQH"/>
    <dbReference type="UniPathway" id="UPA00186">
        <property type="reaction ID" value="UER00284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06830">
        <property type="entry name" value="PLPDE_III_ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01417">
        <property type="entry name" value="SpeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040634">
        <property type="entry name" value="Arg_decarb_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041128">
        <property type="entry name" value="Arg_decarbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002985">
        <property type="entry name" value="Arg_decrbxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43295">
        <property type="entry name" value="PTHR43295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17810">
        <property type="entry name" value="Arg_decarb_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17944">
        <property type="entry name" value="Arg_decarbox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001336">
        <property type="entry name" value="Arg_decrbxlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01180">
        <property type="entry name" value="ARGDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01273">
        <property type="entry name" value="speA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0661">Putrescine biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="14">
        <location>
            <begin position="100"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_decarb_HB" evidence="15">
        <location>
            <begin position="392"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_decarbox_C" evidence="16">
        <location>
            <begin position="606"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate-binding" evidence="12">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12 13">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001336-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB63148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="658" mass="73886" checksum="87106BF8727B6EE2" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C09</accession>
    <name>Q32C09_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqgC</name>
        <name evidence="1" type="ordered locus">SDY_3132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378864.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404637.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C09"/>
    <dbReference type="EnsemblBacteria" id="ABB63146">
        <property type="protein sequence ID" value="ABB63146"/>
        <property type="gene ID" value="SDY_3132"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3132"/>
    <dbReference type="HOGENOM" id="CLU_202419_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020102">
        <property type="entry name" value="YqgC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17430">
        <property type="entry name" value="YqgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8100" checksum="5157B1D533F2CC34" modified="2005-12-06" version="1">MGITSAGMQSRDAECGERIFTRSVRQVKQQTTVHYFVSPPRPPVKTNPQAKTLISTRLEVATRKKRRVLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C16</accession>
    <name>Q32C16_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GSH synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <shortName evidence="10">GSHase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">gshB</name>
        <name evidence="13" type="ordered locus">SDY_3125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the prokaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000593287.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404630.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C16"/>
    <dbReference type="STRING" id="300267.SDY_3125"/>
    <dbReference type="EnsemblBacteria" id="ABB63139">
        <property type="protein sequence ID" value="ABB63139"/>
        <property type="gene ID" value="SDY_3125"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3125"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3735"/>
    <dbReference type="HOGENOM" id="CLU_068239_0_0_6"/>
    <dbReference type="OMA" id="WMRKDPP"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00162">
        <property type="entry name" value="GSH_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006284">
        <property type="entry name" value="Glut_synth_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004218">
        <property type="entry name" value="GSHS_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004215">
        <property type="entry name" value="GSHS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621:SF4">
        <property type="entry name" value="PTHR21621:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02955">
        <property type="entry name" value="GSH-S_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02951">
        <property type="entry name" value="GSH-S_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01380">
        <property type="entry name" value="glut_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="125"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="316" mass="35576" checksum="9BCDD086D03E2EE1" modified="2005-12-06" version="1">MIKLGIVMDPIANINIKKDSSFAMLLEAQRRGYELHYMEMGDLYLINGEARAYTCTLNVKQNYEEWFSFVGEQDLPLADLDVILMRKEPPFDTEFIYATYILERAEEKGTLIVNKPQSLRDCNEKLFTAWFSDLTPETLVTRNKAQLKAFWEKHSDIILKPLDGMGGASIFRVKEGDPNLGVIAETLTEHGTRYCMVQNYLPAIKDGDKRVLVVDGEPVPYCLARIPQGGETRGNLAAGGRGEPRPLTESDWKIARQIGPTLKEKGLIFVGLDIIGDRLTEINVTSPTCIREIEAEFPVSITGMLMDAIEARLQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C50</accession>
    <name>Q32C50_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404596.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C50"/>
    <dbReference type="STRING" id="300267.SDY_3089"/>
    <dbReference type="EnsemblBacteria" id="ABB63105">
        <property type="protein sequence ID" value="ABB63105"/>
        <property type="gene ID" value="SDY_3089"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3089"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3697"/>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_6"/>
    <dbReference type="OMA" id="FFNRFAA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="325" mass="35989" checksum="C00923299E799A45" modified="2005-12-06" version="1">MNQTVAVTGATGFIGKYIIDNLLVRGFHVRALTRTARAHVNDNLTWVRGSLEDTHSLSELVAGASAVVHCAGQVRGHKEEIFTHCNVDGSLHLMQAAKESGFCQRFLFISSLAARHPELSWYANSKHVAEQRLTAMADEITLGVFRPTAVYGPGDKELKPLFDWMLRGLLPRLGAPDTQLSFLHVTDFAQAVGQWLSAETVQTQTYELCDGVAGSYDWQRVQQLAADARCGSVRMVGIPLPVLTCLADISTALSRLAGKEPMLTRSKIRELTHADWSASNNRISEDINWFPGISLEHALGNDSNLLIVFYVQIMPDDFVMQLHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CK0</accession>
    <name>Q32CK0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404446.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CK0"/>
    <dbReference type="STRING" id="300267.SDY_2929"/>
    <dbReference type="EnsemblBacteria" id="ABB62955">
        <property type="protein sequence ID" value="ABB62955"/>
        <property type="gene ID" value="SDY_2929"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2929"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3518"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27462" checksum="A06D0A835B372B08" modified="2005-12-06" version="1">MAHIRTRETYGARRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFSPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRCHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CL0</accession>
    <name>Q32CL0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable iron-sulfur protein of hydrogenase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hycF</name>
        <name evidence="7" type="ordered locus">SDY_2917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000493802.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404436.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CL0"/>
    <dbReference type="STRING" id="300267.SDY_2917"/>
    <dbReference type="EnsemblBacteria" id="ABB62945">
        <property type="protein sequence ID" value="ABB62945"/>
        <property type="gene ID" value="SDY_2917"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2917"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3504"/>
    <dbReference type="HOGENOM" id="CLU_067218_3_1_6"/>
    <dbReference type="OMA" id="AEHHRES"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="180" mass="20356" checksum="DF59D5FAD9CDF767" modified="2005-12-06" version="1">MFTFIKKVIKTGTATSSYPLEPIAVDKNFRGKPEQNPQQCIGCAACVNACPSNALTVETDLATGELVWEFNLGRCIFCGRCEEVCPTAAIKLSQEYELAVWKKEDFLQQSRFALCNCRVCNRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECKRQKCLVPSDRIELTRHMKEAI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CL7</accession>
    <name>NORW_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitric oxide reductase FlRd-NAD(+) reductase</fullName>
            <ecNumber evidence="1">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Flavorubredoxin reductase</fullName>
            <shortName evidence="1">FlRd-reductase</shortName>
            <shortName evidence="1">FlavoRb reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">norW</name>
        <name evidence="1" type="synonym">flrR</name>
        <name type="ordered locus">SDY_2908</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] = NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]</text>
            <dbReference type="Rhea" id="RHEA:42960"/>
            <dbReference type="Rhea" id="RHEA-COMP:10304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10305"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; nitric oxide reduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000064743.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404429.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CL7"/>
    <dbReference type="SMR" id="Q32CL7"/>
    <dbReference type="STRING" id="300267.SDY_2908"/>
    <dbReference type="EnsemblBacteria" id="ABB62938">
        <property type="protein sequence ID" value="ABB62938"/>
        <property type="gene ID" value="SDY_2908"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2908"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3493"/>
    <dbReference type="HOGENOM" id="CLU_003291_4_4_6"/>
    <dbReference type="OMA" id="IHHFWTF"/>
    <dbReference type="UniPathway" id="UPA00638"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016731">
        <property type="term" value="F:oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01313">
        <property type="entry name" value="NorW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023961">
        <property type="entry name" value="NO_rdtase_NorW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041364">
        <property type="entry name" value="Rbx-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18113">
        <property type="entry name" value="Rbx_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000305611" description="Nitric oxide reductase FlRd-NAD(+) reductase">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01313"/>
        </source>
    </evidence>
    <sequence length="377" mass="41289" checksum="2253235A8EDC5445" modified="2005-12-06" version="1">MSNGIVIIGSGFAARQLVKNIRKQDATIPLTLIAADSMDEYNKPDLSHVISQGQRADDLTRQTAGEFAEQFNLHLFPHTWVTDIDAEARVVKSQNNQWQYDKLVLATGASAFVPSVPGRELMLTLNSQQEYRACETQLRDARRVLIVGGGLIGSELAMDFCRAGKMVTLIDNAASILASLMPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTDSGILATLDRQRSIEVDAVIAATGLRPETALARRAGLTINRGVCVDSYLQTSNADIYALGDCAEINGQVLPFLQPIQLSAMVLAKNLLGNNTPLKLPAMLVKIKTPELPLHLAGETQRQDLRWQINTESQGMVARGVDDADQLRAFVVSEDRMKEAFGLLKTLPV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CN0</accession>
    <name>RECX_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recX</name>
        <name type="ordered locus">SDY_2894</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000140518.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404416.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CN0"/>
    <dbReference type="SMR" id="Q32CN0"/>
    <dbReference type="STRING" id="300267.SDY_2894"/>
    <dbReference type="EnsemblBacteria" id="ABB62925">
        <property type="protein sequence ID" value="ABB62925"/>
        <property type="gene ID" value="SDY_2894"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2894"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3477"/>
    <dbReference type="HOGENOM" id="CLU_066607_3_2_6"/>
    <dbReference type="OMA" id="RCKMQEK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000065204" description="Regulatory protein RecX">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <sequence length="166" mass="19505" checksum="F923CF3DAF6101AC" modified="2005-12-06" version="1">MTESTSRRPAYARLLDRAVRILAVRDHSEQELRRKLVAPIMGKNGPEEIDATAEDYERVIAWCHEHGYLDDSRFVARFIASRSRKGYGPARIRQELNQKGISREATEKAMRECDIDWCALARDHATRKYDEPLPTVFSEKVKIQRFLLYRGYLMEDIQDIWRNFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D54</accession>
    <name>Q32D54_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 16" type="primary">guaB</name>
        <name evidence="16" type="ordered locus">SDY_2704</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005017448.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404242.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D54"/>
    <dbReference type="STRING" id="300267.SDY_2704"/>
    <dbReference type="EnsemblBacteria" id="ABB62751">
        <property type="protein sequence ID" value="ABB62751"/>
        <property type="gene ID" value="SDY_2704"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2704"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3262"/>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_6"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="93"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="153"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="338"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="385"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="248"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="298"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB62751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="488" mass="52052" checksum="F4E8BA1E5929B1E2" modified="2005-12-06" version="1">MLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTEENELEGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKESPNYRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D85</accession>
    <name>Q32D85_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bcp</name>
        <name evidence="6" type="ordered locus">SDY_2669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001068682.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404211.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D85"/>
    <dbReference type="SMR" id="Q32D85"/>
    <dbReference type="STRING" id="300267.SDY_2669"/>
    <dbReference type="EnsemblBacteria" id="ABB62720">
        <property type="protein sequence ID" value="ABB62720"/>
        <property type="gene ID" value="SDY_2669"/>
    </dbReference>
    <dbReference type="GeneID" id="66673655"/>
    <dbReference type="KEGG" id="sdy:SDY_2669"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3220"/>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_6"/>
    <dbReference type="OMA" id="RVVVYFY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="156" mass="17634" checksum="C7D267A671409EFC" modified="2005-12-06" version="1">MNPLKAGDIAPKFSLPDQDGEQVNLTDFQGQRVLVYFYPKAMTPGCTVQACGLRDNMDELKKAGVDVLGISTDKPEKLSRFAEKELLNFTLLSDEDHQVCEQFGVWGEKSFMGKTYDGIHRISFLIDADGKIEHVFDDFKTSNHHDVVLNWLKEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DD2</accession>
    <name>Q32DD2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding component of sulfate permease A protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cysA</name>
        <name evidence="7" type="ordered locus">SDY_2618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000021037.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404164.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DD2"/>
    <dbReference type="STRING" id="300267.SDY_2618"/>
    <dbReference type="EnsemblBacteria" id="ABB62673">
        <property type="protein sequence ID" value="ABB62673"/>
        <property type="gene ID" value="SDY_2618"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2618"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3155"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_6"/>
    <dbReference type="OMA" id="HLGWEIQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102025">
        <property type="term" value="F:ABC-type thiosulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03296">
        <property type="entry name" value="ABC_CysA_sulfate_importer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005666">
        <property type="entry name" value="Sulph_transpt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00968">
        <property type="entry name" value="3a0106s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="365" mass="41058" checksum="37FCCA346ED12968" modified="2005-12-06" version="1">MSIEIANIKKSFGRTQVLNDISLDIPSGQMVALLGPSGSGKTTLLRIIAGLEHQTSGHIRFHGTDVSRLHARDRKVGFVFQHYALFRHMTVFDNIAFGLTVLPRRERPNAAAIKAKVTKLLEMVQLAHLADRYPAQLSGGQKQRVALARALAVEPQILLLDEPFGALDAQVRKELRRWLRQLHEELKFTSVFVTHDQEEATEVADRVVVMSQGNIEQADAPDQVWREPATRFVLEFMGEVNRLQGTIRGGQFHVGAHRWPLGYTPAYQGPVDLFLRPWEVDISRRTSLDSPLPVQVLEASPKGHYTQLVVQPLGWYNEPLTVVMHGDNAPQRGERLFVGLQHARLYNGDERIETRDEELALAQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DF1</accession>
    <name>Q32DF1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nupC</name>
        <name evidence="10" type="ordered locus">SDY_2593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000376337.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404145.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DF1"/>
    <dbReference type="SMR" id="Q32DF1"/>
    <dbReference type="STRING" id="300267.SDY_2593"/>
    <dbReference type="EnsemblBacteria" id="ABB62654">
        <property type="protein sequence ID" value="ABB62654"/>
        <property type="gene ID" value="SDY_2593"/>
    </dbReference>
    <dbReference type="GeneID" id="66673737"/>
    <dbReference type="KEGG" id="sdy:SDY_2593"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3129"/>
    <dbReference type="HOGENOM" id="CLU_016813_0_0_6"/>
    <dbReference type="OMA" id="WFFLNSN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018270">
        <property type="entry name" value="C_nuclsd_transpt_met_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="PTHR10590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00804">
        <property type="entry name" value="nupC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="9">
        <location>
            <begin position="92"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_C" evidence="8">
        <location>
            <begin position="193"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="400" mass="43476" checksum="1EA1DE138C4351CE" modified="2005-12-06" version="1">MDRVLHFVLALAVVAILALLVSSDRKKIRIRYVIQLLVIEVLLAWFFLNSDVGLGFVKGFSEMFEKLLGFANEGTNFVFGSMNDQGLAFFFLKVLCPIVFISALIGILQHIRVLPVIIRAIGFLLSKVNGMGKLESFNAVSSLILGQSENFIAYKDILGKISRNRMYTMAATAMSTVSMSIVGAYMTMLEPKYVVAALVLNMFSTFIVLSLINPYRVDASEENIQMSNLHEGQSFFEMLGEYILAGFKVAIIVAAMLIGFIALIAALNALFATVTGWFGYSISFQGILGYIFYPIAWVMGVPSSEALQVGSIMATKLVSNEFVAMMDLQKIASTLSPRAEGIISVFLVSFANFSSIGIIAGAVKGLNEEQGNVVSRFGLKLVYGSTLVSVLSASIAALVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DP8</accession>
    <name>5DNU_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5'-deoxynucleotidase YfbR</fullName>
            <ecNumber evidence="1">3.1.3.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5'-deoxyribonucleotidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfbR</name>
        <name type="ordered locus">SDY_2487</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5DNU family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000813857.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404048.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DP8"/>
    <dbReference type="SMR" id="Q32DP8"/>
    <dbReference type="STRING" id="300267.SDY_2487"/>
    <dbReference type="EnsemblBacteria" id="ABB62557">
        <property type="protein sequence ID" value="ABB62557"/>
        <property type="gene ID" value="SDY_2487"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2487"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2998"/>
    <dbReference type="HOGENOM" id="CLU_084784_0_0_6"/>
    <dbReference type="OMA" id="NQSHFFA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01100">
        <property type="entry name" value="5DNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022971">
        <property type="entry name" value="YfbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000064958" description="5'-deoxynucleotidase YfbR">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="18"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="77"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Appears to be important in orienting the phosphate for catalysis" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01175"/>
        </source>
    </evidence>
    <sequence length="199" mass="22636" checksum="E5344C6AC30DA053" modified="2005-12-06" version="1">MKQSHFFAHLSRLKLINRWPLMRNVRTENVSEHSLQVAMVAHALAAIKNRKFGGNVNAERIALLAMYHDASEVLTGDLPTPVKYFNSQIAQEYKAIEKIAQQKLVDMVPEELRDIFAPLIDEHAYSDEEKSLVKQADALCAYLKCLEELAAGNNEFLLAKTRLEATLAARRSQEMDYFMEVFVPSFHLSLDEISQDSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DV9</accession>
    <name>Q32DV9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">gyrA</name>
        <name evidence="11" type="ordered locus">SDY_2423</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001281279.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403987.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DV9"/>
    <dbReference type="STRING" id="300267.SDY_2423"/>
    <dbReference type="EnsemblBacteria" id="ABB62496">
        <property type="protein sequence ID" value="ABB62496"/>
        <property type="gene ID" value="SDY_2423"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2423"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2921"/>
    <dbReference type="HOGENOM" id="CLU_002977_6_2_6"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="11"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="841"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="560"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="845"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="875" mass="97038" checksum="4A71AC9FF1EE406C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E53</accession>
    <name>Q32E53_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pepN</name>
        <name evidence="15" type="ordered locus">SDY_2325</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000193837.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403893.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E53"/>
    <dbReference type="STRING" id="300267.SDY_2325"/>
    <dbReference type="MEROPS" id="M01.005"/>
    <dbReference type="EnsemblBacteria" id="ABB62402">
        <property type="protein sequence ID" value="ABB62402"/>
        <property type="gene ID" value="SDY_2325"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2325"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2806"/>
    <dbReference type="HOGENOM" id="CLU_007993_2_0_6"/>
    <dbReference type="OMA" id="FKRWYSQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038438">
        <property type="entry name" value="PepN_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012779">
        <property type="entry name" value="Peptidase_M1_pepN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024601">
        <property type="entry name" value="Peptidase_M1_pepN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037144">
        <property type="entry name" value="Peptidase_M1_pepN_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035414">
        <property type="entry name" value="Peptidase_M1_pepN_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46322">
        <property type="entry name" value="PTHR46322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11940">
        <property type="entry name" value="DUF3458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17432">
        <property type="entry name" value="DUF3458_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02414">
        <property type="entry name" value="pepN_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="14">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="11">
        <location>
            <begin position="225"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3458" evidence="12">
        <location>
            <begin position="444"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3458_C" evidence="13">
        <location>
            <begin position="548"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB62402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="870" mass="98983" checksum="D9964330B47A11EC" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E67</accession>
    <name>YCEI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YceI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yceI</name>
        <name type="ordered locus">SDY_2311</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0312 family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000749273.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403879.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E67"/>
    <dbReference type="SMR" id="Q32E67"/>
    <dbReference type="STRING" id="300267.SDY_2311"/>
    <dbReference type="EnsemblBacteria" id="ABB62388">
        <property type="protein sequence ID" value="ABB62388"/>
        <property type="gene ID" value="SDY_2311"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2311"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2789"/>
    <dbReference type="HOGENOM" id="CLU_071003_1_2_6"/>
    <dbReference type="OMA" id="GNYRAGF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00780">
        <property type="entry name" value="UPF0312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023480">
        <property type="entry name" value="UPF0312/YceI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000226326" description="Protein YceI">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00780"/>
        </source>
    </evidence>
    <sequence length="195" mass="21497" checksum="707132B059D5B346" modified="2005-12-06" version="1" precursor="true">MKKSLLGLTFASLMFSTGSAVAADYKIDKEGQHAFVNFRIQHLGYSWLYGTFKDFDGTFTFDEKNPAADKVNVTINTTSVDTNHAERDKHLRSADFLNAAKYPQATFTSTSVKKDGDELNITGDLTLNGVTKPVTLEAKLIGQGDDPWGGKRAGFEAEGKIKLKDFNIKTDLGPASQEVDLRCTGNSGHYHLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E97</accession>
    <name>Q32E97_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E97"/>
    <dbReference type="STRING" id="300267.SDY_2281"/>
    <dbReference type="EnsemblBacteria" id="ABB62358">
        <property type="protein sequence ID" value="ABB62358"/>
        <property type="gene ID" value="SDY_2281"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2281"/>
    <dbReference type="HOGENOM" id="CLU_1552956_0_0_6"/>
    <dbReference type="OMA" id="PEYTIKQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024572">
        <property type="entry name" value="RcnB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11776">
        <property type="entry name" value="RcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="172" mass="19431" checksum="28E86CA1F2133D79" modified="2005-12-06" version="1">MILKSAYSAHFSLNEDAFATSFHLHFLRNHGITNKISLVGYIVWRERYTTDFTDPQSGEYMTIKNKMLLGALLLVTSAAWAAPATAGSTNASGISTYELSSFIADFKHFKLGDTVPEMYRTDEYNIKQWQLRNLPAPDAGTHWTYMGGAYVLINNTDGKIIKAYDGEIFYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EC9</accession>
    <name>Q32EC9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">erfK</name>
        <name evidence="10" type="ordered locus">SDY_2243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403817.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EC9"/>
    <dbReference type="STRING" id="300267.SDY_2243"/>
    <dbReference type="MEROPS" id="C82.A02"/>
    <dbReference type="EnsemblBacteria" id="ABB62326">
        <property type="protein sequence ID" value="ABB62326"/>
        <property type="gene ID" value="SDY_2243"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2243"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2713"/>
    <dbReference type="HOGENOM" id="CLU_046834_0_1_6"/>
    <dbReference type="OMA" id="KQEGPTW"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041597">
        <property type="entry name" value="Ldt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17969">
        <property type="entry name" value="Ldt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220678" evidence="7">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="8">
        <location>
            <begin position="96"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Ldt_C" evidence="9">
        <location>
            <begin position="234"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="310" mass="34367" checksum="ACB41FE1E18070F9" modified="2005-12-06" version="1">MRRVNILCSFALLFASHTSLAVTYPLPPEGSRLVGQSFTVTVPDHNTQPLETFAAQYGQGLSNMLEANPGADVFLPKSGSQLTIPQQLILPATVRKGIVVNVAEMRLYYYPPDSNTVEVFPIGIGQAGRETPRNWVTTVERKQEAPTWTPTPNTRREYAKRGESLPAFVPAGPDNPMGLYAIYIGRLYAIHGTNANFGIGLRVSQGCIRLRNDDIKYLFDNVPVGTRVQIIDQPVKYTTEPDGSNWLEVHEPLSRNRAEYESDRKVPLPVTPSLRAFINGQEVDVNRANAALQRRSGMPVQISSGSRQMF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EE9</accession>
    <name>HISX_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidinol dehydrogenase</fullName>
            <shortName evidence="1">HDH</shortName>
            <ecNumber evidence="1">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisD</name>
        <name type="ordered locus">SDY_2221</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021699.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403797.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EE9"/>
    <dbReference type="SMR" id="Q32EE9"/>
    <dbReference type="STRING" id="300267.SDY_2221"/>
    <dbReference type="EnsemblBacteria" id="ABB62306">
        <property type="protein sequence ID" value="ABB62306"/>
        <property type="gene ID" value="SDY_2221"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2221"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2685"/>
    <dbReference type="HOGENOM" id="CLU_006732_3_0_6"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000135843" description="Histidinol dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <sequence length="434" mass="46095" checksum="A193208E2A5A3034" modified="2005-12-06" version="1">MSFNTIIDWNSCTAEQQRQLLMRPAISTSESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALTVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPARIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALSASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARVLVDGITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EH6</accession>
    <name>Q32EH6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yegD</name>
        <name evidence="4" type="ordered locus">SDY_2193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EH6"/>
    <dbReference type="STRING" id="300267.SDY_2193"/>
    <dbReference type="EnsemblBacteria" id="ABB62279">
        <property type="protein sequence ID" value="ABB62279"/>
        <property type="gene ID" value="SDY_2193"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2193"/>
    <dbReference type="HOGENOM" id="CLU_033976_0_0_6"/>
    <dbReference type="OMA" id="HEYLEGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10231">
        <property type="entry name" value="YegD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042054">
        <property type="entry name" value="YegD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="471" mass="51879" checksum="B56D51D169BC1528" modified="2005-12-06" version="1">MSRRQHFAKVTPLLHRHGDYFVFIGFDYGTANCSVAVMRDGKPHLLKMENDSTLLPSMLCAPTREAVSEWLYRHHDVPADDDETQALLRRAIRYNREEDIDVTAKSVQFGLSSLAQYIDDPEEVWFVKSPKSFLGASGLKPQQVALFEDLVCAMMLHIRQQAQAQLPEAITQAVIGRPINFQGLGGDEANAQAQGILERAAKRAGFRDVVFQYEPVAAGLDYEATLQEEKRVLVVDIGGGTTDCSLLLMGPQWRSRLYREASLLGHSGCRIGGNDLDIALAFKNLMPLLGMGGETEKGIALPILPWWNAVAINDVPAQSDFYSSANGRLLNDLVRDAREPEKVALLQKVWRQRLSYRLVRSAEECKIALSSVAETRASLPFISDELATLISQQGLESALSQPLARILEQVQLALDNAQEKPDVIYLTGGSARSPLIKKALAEQLPGIPIAGGDDFGSVTAGLARWAEVVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EK7</accession>
    <name>Q32EK7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yehV</name>
        <name evidence="2" type="ordered locus">SDY_2162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001240406.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403739.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EK7"/>
    <dbReference type="STRING" id="300267.SDY_2162"/>
    <dbReference type="EnsemblBacteria" id="ABB62248">
        <property type="protein sequence ID" value="ABB62248"/>
        <property type="gene ID" value="SDY_2162"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2162"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2614"/>
    <dbReference type="HOGENOM" id="CLU_045945_0_1_6"/>
    <dbReference type="OMA" id="EQGWRVD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="243" mass="28030" checksum="239B67A1FDD11748" modified="2005-12-06" version="1">MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKMLLSNENVDVQNGWRDQQETLLTYLQSGNLHSLRTWIKERGQDYPAQTLTTHLFIPLRRRLQCQQPTLQALLAIPDGVLINYIAICLASARKKQGKDALVVGWNIQDTTRLWLEGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENRTSAQQQQLTSWQEQGHDIFPLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EL2</accession>
    <name>Q32EL2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Quinone-dependent D-lactate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.5.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">D-lactate dehydrogenase</fullName>
            <shortName evidence="2">D-LDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">dld</name>
        <name evidence="7" type="ordered locus">SDY_2155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Catalyzes the oxidation of D-lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>(R)-lactate + a quinone = a quinol + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:51468"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the quinone-dependent D-lactate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.12" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000097406.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403734.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EL2"/>
    <dbReference type="STRING" id="300267.SDY_2155"/>
    <dbReference type="EnsemblBacteria" id="ABB62243">
        <property type="protein sequence ID" value="ABB62243"/>
        <property type="gene ID" value="SDY_2155"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2155"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2605"/>
    <dbReference type="HOGENOM" id="CLU_034094_0_0_6"/>
    <dbReference type="OMA" id="YEHHLML"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031234">
        <property type="term" value="C:extrinsic component of cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102029">
        <property type="term" value="F:D-lactate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.610">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02092">
        <property type="entry name" value="DLDH_Dld"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016172">
        <property type="entry name" value="D-lactate_DH_C-sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016173">
        <property type="entry name" value="D-lactate_DH_C-sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012256">
        <property type="entry name" value="D_lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015409">
        <property type="entry name" value="Lactate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09330">
        <property type="entry name" value="Lact-deh-memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000101">
        <property type="entry name" value="D-lactate_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="2 3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2 4">
        <location>
            <begin position="76"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 4">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="571" mass="64706" checksum="7A8FB62ED0663801" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EX6</accession>
    <name>Q32EX6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ycfU</name>
        <name evidence="11" type="ordered locus">SDY_2034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022106.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403620.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EX6"/>
    <dbReference type="STRING" id="300267.SDY_2034"/>
    <dbReference type="EnsemblBacteria" id="ABB62129">
        <property type="protein sequence ID" value="ABB62129"/>
        <property type="gene ID" value="SDY_2034"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2034"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2447"/>
    <dbReference type="HOGENOM" id="CLU_000604_8_1_6"/>
    <dbReference type="OMA" id="GWWQQNG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011925">
        <property type="entry name" value="LolCE_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02212">
        <property type="entry name" value="lolCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="27"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="295"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="399" mass="43294" checksum="FB7A2D6AF13A1641" modified="2005-12-06" version="1">MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSSEHGSLNPQQLPETAVKLDGVNRVAPITTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQTDLEPGKYNVILGEQLASQLSVNRGDQIRVMVPSASQFTPMGRIPSQRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKLPEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGASAGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAIEPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F35</accession>
    <name>Q32F35_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295496.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403561.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F35"/>
    <dbReference type="EnsemblBacteria" id="ABB62070">
        <property type="protein sequence ID" value="ABB62070"/>
        <property type="gene ID" value="SDY_1970"/>
    </dbReference>
    <dbReference type="GeneID" id="66674287"/>
    <dbReference type="KEGG" id="sdy:SDY_1970"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2378"/>
    <dbReference type="HOGENOM" id="CLU_216752_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019672">
        <property type="entry name" value="DUF2527"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10736">
        <property type="entry name" value="DUF2527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="47" mass="5212" checksum="54E439F3531D708F" modified="2005-12-06" version="1">MCGIFSKEVLSKHVDVEYRFSAEPYIGASCSNVSVLSMLCLRAKKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F99</accession>
    <name>Q32F99_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403497.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F99"/>
    <dbReference type="STRING" id="300267.SDY_1900"/>
    <dbReference type="EnsemblBacteria" id="ABB62006">
        <property type="protein sequence ID" value="ABB62006"/>
        <property type="gene ID" value="SDY_1900"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1900"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2285"/>
    <dbReference type="HOGENOM" id="CLU_111062_0_0_6"/>
    <dbReference type="OMA" id="GLCEWLE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="215" mass="24467" checksum="5DBFE619FC7D1101" modified="2005-12-06" version="1">MGKMNHQDELPLAKVSEVDEAKRQWLQGMRHPVDTVTEPEPAEILAEFIRQHSVAGQLVARAVFLSPPYSVAEEELSVLLESIKQNGDYADIACMTGSQDDYYYSTQPMSENYAAMSLQVVEQDICRAIAHAVRFECQTYPRPYKVAMLMQAPYYFQEAQIEAAIAAMDVAPEYADIRQVESSTAVLYLFSERFMTYGKAYGLCEWFEVEQFQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FD4</accession>
    <name>Q32FD4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MliC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ydhA</name>
        <name evidence="6" type="ordered locus">SDY_1862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FD4"/>
    <dbReference type="STRING" id="300267.SDY_1862"/>
    <dbReference type="EnsemblBacteria" id="ABB61971">
        <property type="protein sequence ID" value="ABB61971"/>
        <property type="gene ID" value="SDY_1862"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1862"/>
    <dbReference type="HOGENOM" id="CLU_166586_0_0_6"/>
    <dbReference type="OMA" id="EYRCDEK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018660">
        <property type="entry name" value="MliC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036328">
        <property type="entry name" value="MliC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09864">
        <property type="entry name" value="MliC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141488">
        <property type="entry name" value="SSF141488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MliC" evidence="5">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="9558" checksum="D457F474F04EF3A3" modified="2005-12-06" version="1">MQTDTLEYQCDEKPLTVKLNNPRQEVSFVYDNQLLHLKQGISASGARYTDGIYVFWSKGEEATVYKRDRIVLNNCQLQNSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FJ5</accession>
    <name>Q32FJ5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydiE</name>
        <name evidence="2" type="ordered locus">SDY_1799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001270809.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403401.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FJ5"/>
    <dbReference type="SMR" id="Q32FJ5"/>
    <dbReference type="STRING" id="300267.SDY_1799"/>
    <dbReference type="EnsemblBacteria" id="ABB61910">
        <property type="protein sequence ID" value="ABB61910"/>
        <property type="gene ID" value="SDY_1799"/>
    </dbReference>
    <dbReference type="GeneID" id="66674401"/>
    <dbReference type="KEGG" id="sdy:SDY_1799"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2171"/>
    <dbReference type="HOGENOM" id="CLU_178563_1_2_6"/>
    <dbReference type="OMA" id="HAGHQER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019600">
        <property type="entry name" value="Hemin_uptake_protein_HemP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10636">
        <property type="entry name" value="hemP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="63" mass="7117" checksum="A1EA3DD6F1DC69A1" modified="2005-12-06" version="1">MRYTDSRKLTPETDANHKTASPQPIRRISSQTLLGPDGKLIIDHDGQEYLLRKTQAGKLLLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FL4</accession>
    <name>Q32FL4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">YnbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ynbD</name>
        <name evidence="10" type="ordered locus">SDY_1776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403382.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FL4"/>
    <dbReference type="STRING" id="300267.SDY_1776"/>
    <dbReference type="EnsemblBacteria" id="ABB61891">
        <property type="protein sequence ID" value="ABB61891"/>
        <property type="gene ID" value="SDY_1776"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1776"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2140"/>
    <dbReference type="HOGENOM" id="CLU_031173_0_0_6"/>
    <dbReference type="OMA" id="QHHFIDI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="208"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="9">
        <location>
            <begin position="267"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="341" mass="39483" checksum="46E8A5D1DF0A5D98" modified="2005-12-06" version="1">MACCGFFLYPLKFSFIRPEVSGVTGWLFSQLELFDLPYNQSPSLHIILCWLLWRHFRQHLAVRWRKVCGGWFLLIAISTLTTWQHHFIDVITGLAVGMLIDWMVPVDRRWNYQKPDQRRIKIALPYVVGACACIVLMELMMMVQLWWSVWLCWPVLSLFIIGRGYGGLGAITTGKDSQGKLPPAVYWLTLPWRIGMWLSMRWFCRRLEPVSKMTAGVYLGAFPRHIPAQNAVLDVTFEFPRGRETKDRLYFCVPILDLVVPEEGELRQAVAMLETLREEQGSVLVHCALGLSRSALVVAAWLLCYGHCKTVNEAISYIRARRPQIVLTDEHKAMLRLWENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FR5</accession>
    <name>Q32FR5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sdaA</name>
        <name evidence="12" type="ordered locus">SDY_1720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000624284.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403331.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FR5"/>
    <dbReference type="STRING" id="300267.SDY_1720"/>
    <dbReference type="EnsemblBacteria" id="ABB61840">
        <property type="protein sequence ID" value="ABB61840"/>
        <property type="gene ID" value="SDY_1720"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1720"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2074"/>
    <dbReference type="HOGENOM" id="CLU_022305_0_1_6"/>
    <dbReference type="OMA" id="RMAMRRN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="3"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="187"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB61840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="454" mass="48923" checksum="A88EBD3087C8F72B" modified="2005-12-06" version="1">MISLFDMFKVGIGPSSSHTVGPMKAGKQFVDDLVEKGLLDSITRVAVDVYGSLSLTGKGHHTDIAIIMGLAGNEPATVDIDSIPGFIRDVEERERLLLAQGQHEVDFPRDNGMRFHNGNLPLHENGMQIHAYNGDEVVYSKTYYSIGGSFIVDEEHFGQDAANEVSVPYPFKSATELLAYCNETGYSLSGLAMQNELALHSKKEIDEYFAHVWQTMQACIDRGMNTEGVLPGPLRVPRRASALRRMLVSSDKLSNDPMNVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPDIYTRYFMAAGAIGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGGSPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIASVKAINAARMALRRTSAPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FT4</accession>
    <name>Q32FT4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator LYSR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yeaT</name>
        <name evidence="3" type="ordered locus">SDY_1700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403312.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FT4"/>
    <dbReference type="STRING" id="300267.SDY_1700"/>
    <dbReference type="EnsemblBacteria" id="ABB61821">
        <property type="protein sequence ID" value="ABB61821"/>
        <property type="gene ID" value="SDY_1700"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1700"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2052"/>
    <dbReference type="HOGENOM" id="CLU_039613_16_4_6"/>
    <dbReference type="OMA" id="PAFISKR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="314" mass="35570" checksum="000A8E46261A18C3" modified="2005-12-06" version="1">MKHKTRIMNNLPLLNDLRVFMLVARRAGFAAVAEELGVSPAFVSKRIALLEQTLNVVLLHRTTRRVTITEEGERIYEWAQRILQDVGQMMDELSDVRQVPQGMLRIISSFGFGRQVVAPALSALAKAYPQLELRFDVEDRLVDLVNEGVDLDIRIGDDIAPNLIARKLATNYRILCASPEFIAQHGAPKHLTDLSALPCLLIKERDHPFGVWQLRNKEGHHAIKVTGPLSSNHGEIVHQWCLDGQGIALRSWWDVSENIASGHLVQVLLEYYQPANVWAVYVSRLATSAKVRITVEFLRQYFAEHYPNFSLEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FX1</accession>
    <name>Q32FX1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cell outer membrane</location>
            <topology evidence="2 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the Gram-negative porin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403275.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FX1"/>
    <dbReference type="STRING" id="300267.SDY_1663"/>
    <dbReference type="EnsemblBacteria" id="ABB61784">
        <property type="protein sequence ID" value="ABB61784"/>
        <property type="gene ID" value="SDY_1663"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1663"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2006"/>
    <dbReference type="HOGENOM" id="CLU_058202_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013793">
        <property type="entry name" value="Porin_Gram-ve_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00267">
        <property type="entry name" value="Porin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00576">
        <property type="entry name" value="GRAM_NEG_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="102" mass="11737" checksum="D0011748CB1EE0E2" modified="2005-12-06" version="1">MTTYGDGYISNKAQSFEVVAQYQFDFGLRPSLAYLKSKGRDLGRYGDQDMIEYIDVGATYFFNKNMSTYVDYKINLIDESDFTRAVDIRTDNIVATGITYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G01</accession>
    <name>Q32G01_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001191033.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403245.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G01"/>
    <dbReference type="STRING" id="300267.SDY_1630"/>
    <dbReference type="EnsemblBacteria" id="ABB61754">
        <property type="protein sequence ID" value="ABB61754"/>
        <property type="gene ID" value="SDY_1630"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1630"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1963"/>
    <dbReference type="HOGENOM" id="CLU_132148_1_0_6"/>
    <dbReference type="OMA" id="QHATGTC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020378">
        <property type="entry name" value="DUF4186"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13811">
        <property type="entry name" value="DUF4186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13512" checksum="70F71789D7DB8D3E" modified="2005-12-06" version="1">MQSLDPLFARLSRSKFRSRFRLGVKERQYCLEKGAPVIEQHAADFVAKRLAPALPANDGKQTPMRGHPVFIAQHATATCCRGCLAKWHNIPQGVSLSEEQQRYIVAVIYHWLVVQMNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G99</accession>
    <name>Q32G99_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022897.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403147.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G99"/>
    <dbReference type="STRING" id="300267.SDY_1519"/>
    <dbReference type="EnsemblBacteria" id="ABB61656">
        <property type="protein sequence ID" value="ABB61656"/>
        <property type="gene ID" value="SDY_1519"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1519"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1818"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="ILTIMGP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="217" mass="23952" checksum="669A8E51CECF640B" modified="2005-12-06" version="1">MLCVKNVSLRLPESCLLTNVNFTVDKGDIVTLMGPSGCGKSTLFSWMIGALPGQFSCTGELWLNEQRIDMLPTAQRQIGILFQDALLFDQFSVGQNLLLALPATLKGNARRNAVNDALERSGLDGAFHQDPATLSGGQRARVALLRALLAQPKALLLDEPFSRLDVALRDNFRQWVFSEVRELAIPVVQVTHDLQDVPADSSALDMAQWSENYNKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GB5</accession>
    <name>Q32GB5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_1502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403131.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GB5"/>
    <dbReference type="EnsemblBacteria" id="ABB61640">
        <property type="protein sequence ID" value="ABB61640"/>
        <property type="gene ID" value="SDY_1502"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1502"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1792"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="MWMTDGW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14948" checksum="446071696C754D90" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVMWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GL6</accession>
    <name>Q32GL6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Lysozyme</fullName>
            <ecNumber evidence="2 6">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_1394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 24 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2 6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000087463.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403030.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GL6"/>
    <dbReference type="STRING" id="300267.SDY_1394"/>
    <dbReference type="CAZy" id="GH24">
        <property type="family name" value="Glycoside Hydrolase Family 24"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61539">
        <property type="protein sequence ID" value="ABB61539"/>
        <property type="gene ID" value="SDY_1394"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1394"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1655"/>
    <dbReference type="HOGENOM" id="CLU_091641_8_0_6"/>
    <dbReference type="OMA" id="NRSNNCY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04110">
        <property type="entry name" value="ENDOLYSIN_T4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04136">
        <property type="entry name" value="SAR_ENDOLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034690">
        <property type="entry name" value="Endolysin_T4_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043688">
        <property type="entry name" value="SAR_endolysin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4 6" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220718" description="Lysozyme" evidence="7">
        <location>
            <begin position="24"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="177" mass="19723" checksum="FBD7A27430189E2E" modified="2005-12-06" version="1">MSRKFRYGLSAVVLALIAVGASAPEILDQFLDEKEGNHTTAYRDGAGIWTICRGAILVDGKPVVPGMKLSKEKCDRVNAIERDKALAWVEKNIRVPLTEPQKAGIASFCPYNIGPSKCFTSTFYRKLNAGDRKGACAEIRRWIYDGGRDCRNRSNNCYGQVSRRDQESALACWSIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GV7</accession>
    <name>Q32GV7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione-binding protein GsiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">oppA</name>
        <name evidence="9" type="ordered locus">SDY_1301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005023475.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402939.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GV7"/>
    <dbReference type="STRING" id="300267.SDY_1301"/>
    <dbReference type="EnsemblBacteria" id="ABB61448">
        <property type="protein sequence ID" value="ABB61448"/>
        <property type="gene ID" value="SDY_1301"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1301"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1547"/>
    <dbReference type="HOGENOM" id="CLU_017028_0_3_6"/>
    <dbReference type="OMA" id="YDFFTWE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220990" description="Glutathione-binding protein GsiB" evidence="7">
        <location>
            <begin position="27"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="8">
        <location>
            <begin position="82"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="543" mass="61021" checksum="81858D08ECB85786" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GX8</accession>
    <name>Q32GX8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="7">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">narG</name>
        <name evidence="15" type="ordered locus">SDY_1279</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000032964.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402918.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GX8"/>
    <dbReference type="STRING" id="300267.SDY_1279"/>
    <dbReference type="EnsemblBacteria" id="ABB61427">
        <property type="protein sequence ID" value="ABB61427"/>
        <property type="gene ID" value="SDY_1279"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1279"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1518"/>
    <dbReference type="HOGENOM" id="CLU_000422_14_1_6"/>
    <dbReference type="OMA" id="DKPSQYF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nitr_red_alph_N"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12 13" id="KW-0411">Iron-sulfur</keyword>
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        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
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        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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        </ligand>
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        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABB61427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1247" mass="140437" checksum="48A0A01E95FC0540" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GZ4</accession>
    <name>Q32GZ4_SHIDS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">SDY_1262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Gammaproteobacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GZ4"/>
    <dbReference type="STRING" id="300267.SDY_1262"/>
    <dbReference type="EnsemblBacteria" id="ABB61411">
        <property type="protein sequence ID" value="ABB61411"/>
        <property type="gene ID" value="SDY_1262"/>
    </dbReference>
    <dbReference type="GeneID" id="66674967"/>
    <dbReference type="KEGG" id="sdy:SDY_1262"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="130" mass="14625" checksum="DC18A2BDCC944224" modified="2005-12-06" version="1">MTSFSTLLSVHLISIALSVGLLTLRFWLRYQKHPQAFARWTRIVPPVVDTVLLLSGIALMAKAHILPFSGQAQWLTEKLFGVIIYIVLGFIALDYRRMHSQQARIIAFPLALVVLYIIIKLATTKVPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H18</accession>
    <name>Q32H18_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pyrophosphorylase ModD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">modD</name>
        <name evidence="8" type="ordered locus">SDY_1236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NadC/ModD family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABB61387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402878.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H18"/>
    <dbReference type="SMR" id="Q32H18"/>
    <dbReference type="STRING" id="300267.SDY_1236"/>
    <dbReference type="EnsemblBacteria" id="ABB61387">
        <property type="protein sequence ID" value="ABB61387"/>
        <property type="gene ID" value="SDY_1236"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1236"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1466"/>
    <dbReference type="HOGENOM" id="CLU_039622_2_1_6"/>
    <dbReference type="OMA" id="GGHIHRQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006242">
        <property type="entry name" value="ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01334">
        <property type="entry name" value="modD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="7">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="6">
        <location>
            <begin position="113"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="284" mass="30553" checksum="2A1C04BE799FF909" modified="2005-12-06" version="1">MIFLSQAQIDALLLEDIQGGDLTTRALNIGHQHGYIEFFLRQGGCVSGVSVACKMLTTLGLTIDDAVSDGSQANAGQRLIRAQGNAAALHQGWKAIQNVLEWSCGVSDYLDQMLALLRERYPDGNIACTRKAIPGTRLLASQAILAAGGLIHRAGCAETILLFANHRHFLHDNQDWSGAINQLRRHAPEKKIVVEADTPKEAIAALRAQPDVLQLDKFSPQQATEIAQIAPSLAPHCTLALTGGINLTTLKNYLDCGIRLFITSAPYYAAPADIKVSLQPAASI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H31</accession>
    <name>DSBB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Disulfide bond formation protein B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Disulfide oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dsbB</name>
        <name type="ordered locus">SDY_1222</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DsbB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000943459.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402865.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H31"/>
    <dbReference type="BMRB" id="Q32H31"/>
    <dbReference type="SMR" id="Q32H31"/>
    <dbReference type="STRING" id="300267.SDY_1222"/>
    <dbReference type="EnsemblBacteria" id="ABB61374">
        <property type="protein sequence ID" value="ABB61374"/>
        <property type="gene ID" value="SDY_1222"/>
    </dbReference>
    <dbReference type="GeneID" id="66674995"/>
    <dbReference type="KEGG" id="sdy:SDY_1222"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1450"/>
    <dbReference type="HOGENOM" id="CLU_098660_2_0_6"/>
    <dbReference type="OMA" id="GGALYMQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00286">
        <property type="entry name" value="DsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003752">
        <property type="entry name" value="DiS_bond_form_DsbB/BdbC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022920">
        <property type="entry name" value="Disulphide_bond_form_DsbB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023380">
        <property type="entry name" value="DsbB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02600">
        <property type="entry name" value="DsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158442">
        <property type="entry name" value="SSF158442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000298415" description="Disulfide bond formation protein B">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="90"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="41"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00286"/>
        </source>
    </evidence>
    <sequence length="176" mass="20142" checksum="9CBD673D51E9F09B" modified="2005-12-06" version="1">MLRFLNQCSQGRGAWLLMAFTALALELTALWFQHVMLLKPCVLCIYERCALFGVLGAALIGAIAPKTPLRYVAMVIWLYSAFRGVQLTYEHTMLQLYPSPFATCDFMVRFPEWLPLDKWVPQVFVASGDCAERQWDFLGLEMPQWLLGIFIAYLIVAVLVVISQPFKAKKRDLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H62</accession>
    <name>Q32H62_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Proton conductor component of motor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">motA</name>
        <name evidence="12" type="ordered locus">SDY_1189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000906323.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402834.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H62"/>
    <dbReference type="STRING" id="300267.SDY_1189"/>
    <dbReference type="EnsemblBacteria" id="ABB61343">
        <property type="protein sequence ID" value="ABB61343"/>
        <property type="gene ID" value="SDY_1189"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1189"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1407"/>
    <dbReference type="HOGENOM" id="CLU_068213_0_0_6"/>
    <dbReference type="OMA" id="EIETHHQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022522">
        <property type="entry name" value="Flagellar_motor_stator_MotA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30433:SF4">
        <property type="entry name" value="PTHR30433:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03818">
        <property type="entry name" value="MotA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="11">
        <location>
            <begin position="138"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB61343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="295" mass="32009" checksum="70F2033844551268" modified="2005-12-06" version="1">MLILLGYLVVLGTVFGGYLMTGGSLGALYQPAELVIIAGAGIGSFIVGNNGKAIKGTLKALPLLFRRSKYTKAMYMDLLALLYRLMAKSRQMGMFSLERDIENPRESEIFASYPRIIADSVMLDFIVDYLRLIISGHMNTFEIEALMDEEIEPHESEAEVPANSLALVGDSLPAFGIVAAVMGVVHALGSADRPAAELGALIAHAMVGTFLGILLAYGFISPLASVLRQKSAETSKMMQCVKVTLLSNLNGYAPPIAVEFGRKTLYSSERLSFIELEEHVRAVKNPQQQTTTEEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H69</accession>
    <name>SYR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="1">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argS</name>
        <name type="ordered locus">SDY_1180</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001025331.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402827.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H69"/>
    <dbReference type="SMR" id="Q32H69"/>
    <dbReference type="STRING" id="300267.SDY_1180"/>
    <dbReference type="EnsemblBacteria" id="ABB61336">
        <property type="protein sequence ID" value="ABB61336"/>
        <property type="gene ID" value="SDY_1180"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1180"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1394"/>
    <dbReference type="HOGENOM" id="CLU_006406_5_1_6"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000242091" description="Arginine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <sequence length="577" mass="64687" checksum="EE38D005A83D1BDD" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H87</accession>
    <name>Q32H87_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_1161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402809.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H87"/>
    <dbReference type="EnsemblBacteria" id="ABB61318">
        <property type="protein sequence ID" value="ABB61318"/>
        <property type="gene ID" value="SDY_1161"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1161"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1367"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="IYAYSTE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="150" mass="17428" checksum="25F0D295C06EDC28" modified="2005-12-06" version="1">MSGNIGANPVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HG2</accession>
    <name>Q32HG2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005023733.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HG2"/>
    <dbReference type="STRING" id="300267.SDY_1080"/>
    <dbReference type="EnsemblBacteria" id="ABB61243">
        <property type="protein sequence ID" value="ABB61243"/>
        <property type="gene ID" value="SDY_1080"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1080"/>
    <dbReference type="HOGENOM" id="CLU_1080703_0_0_6"/>
    <dbReference type="OMA" id="YWIFLPR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="261" mass="28134" checksum="2815381E56ABD458" modified="2005-12-06" version="1">MINITPTDYGGSSKQTDELRVAIVSETLKIPARGVKISIGLGFGNQIIDKGVYIVDGASSGGEPRVVDFTAKAAPMNASKGSPTVQSKKTRSWSDVTVSNIVATIASDNGLKPRVSKRFADNIITQLDQVGESDMHLMSRLATRFDAVSKPAVGYWIFLPRGAGESVSGAPLQHYTLTRRDNSSWGYSRNGQNGDSGGGGENPEPTYLIKYHDTATGQIKELRTAVAEILSLNGRQLSRRSTQRKKLHQGSRAVQLKKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HM1</accession>
    <name>Q32HM1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0495</name>
        <name evidence="3" type="ordered locus">SDY_1019</name>
        <name evidence="4" type="ordered locus">SDY_1078</name>
        <name evidence="5" type="ordered locus">SDY_1162</name>
        <name evidence="6" type="ordered locus">SDY_2168</name>
        <name evidence="7" type="ordered locus">SDY_2979</name>
        <name evidence="8" type="ordered locus">SDY_3699</name>
        <name evidence="9" type="ordered locus">SDY_4585</name>
    </gene>
    <organism evidence="3 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60702">
        <property type="protein sequence ID" value="ABB60702"/>
        <property type="gene ID" value="SDY_0495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61184">
        <property type="protein sequence ID" value="ABB61184"/>
        <property type="gene ID" value="SDY_1019"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61241">
        <property type="protein sequence ID" value="ABB61241"/>
        <property type="gene ID" value="SDY_1078"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61319">
        <property type="protein sequence ID" value="ABB61319"/>
        <property type="gene ID" value="SDY_1162"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62254">
        <property type="protein sequence ID" value="ABB62254"/>
        <property type="gene ID" value="SDY_2168"/>
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        <property type="protein sequence ID" value="ABB63002"/>
        <property type="gene ID" value="SDY_2979"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63662">
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        <property type="gene ID" value="SDY_3699"/>
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    <dbReference type="EnsemblBacteria" id="ABB64446">
        <property type="protein sequence ID" value="ABB64446"/>
        <property type="gene ID" value="SDY_4585"/>
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    <dbReference type="KEGG" id="sdy:SDY_1019"/>
    <dbReference type="KEGG" id="sdy:SDY_1078"/>
    <dbReference type="KEGG" id="sdy:SDY_1162"/>
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    <dbReference type="KEGG" id="sdy:SDY_2979"/>
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    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="WRFAREL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
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    </dbReference>
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        <property type="entry name" value="HTH-like_dom"/>
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        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rve_3"/>
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    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="31988" checksum="D1E62AB6FDA7CE02" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAGTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HX5</accession>
    <name>Q32HX5_SHIDS</name>
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        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spr</name>
        <name evidence="4" type="ordered locus">SDY_0904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000241011.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402571.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HX5"/>
    <dbReference type="SMR" id="Q32HX5"/>
    <dbReference type="STRING" id="300267.SDY_0904"/>
    <dbReference type="MEROPS" id="C40.004"/>
    <dbReference type="EnsemblBacteria" id="ABB61080">
        <property type="protein sequence ID" value="ABB61080"/>
        <property type="gene ID" value="SDY_0904"/>
    </dbReference>
    <dbReference type="GeneID" id="67414541"/>
    <dbReference type="KEGG" id="sdy:SDY_0904"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1045"/>
    <dbReference type="HOGENOM" id="CLU_016043_9_1_6"/>
    <dbReference type="OMA" id="MHAVNDK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220852" evidence="2">
        <location>
            <begin position="34"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="64"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="188" mass="21040" checksum="65DCEEDBDDC76098" modified="2005-12-06" version="1">MVKSQPILRYILRGIPAIAVAVLLSACSANNTAKNMHPETRAVGSETSSLQASQDEFENLVRNVDVKSRIMDQYADWKGVRYRLGGSTKKGIDCSGFVQRTFREQFGLELPRSTYEQQEMGKSVSRSNLRTGDLVLFRAGSTGRHVGIYIGNNQFVHASTSSGVIISSMNEPYWKKRYNEARRVLSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HY0</accession>
    <name>Q32HY0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yejF</name>
        <name evidence="6" type="ordered locus">SDY_0899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000194869.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402566.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HY0"/>
    <dbReference type="STRING" id="300267.SDY_0899"/>
    <dbReference type="EnsemblBacteria" id="ABB61075">
        <property type="protein sequence ID" value="ABB61075"/>
        <property type="gene ID" value="SDY_0899"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0899"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1040"/>
    <dbReference type="HOGENOM" id="CLU_000604_86_0_6"/>
    <dbReference type="OMA" id="YEACPND"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="287"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="529" mass="58713" checksum="458A911F83D2E32A" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I55</accession>
    <name>Q32I55_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0350</name>
        <name evidence="3" type="ordered locus">SDY_0820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60565">
        <property type="protein sequence ID" value="ABB60565"/>
        <property type="gene ID" value="SDY_0350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61002">
        <property type="protein sequence ID" value="ABB61002"/>
        <property type="gene ID" value="SDY_0820"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0350"/>
    <dbReference type="KEGG" id="sdy:SDY_0820"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="RSIPPRM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32102" checksum="7290ED94D7077050" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRIYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGDFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I83</accession>
    <name>Q32I83_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001538493.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402463.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I83"/>
    <dbReference type="STRING" id="300267.SDY_0792"/>
    <dbReference type="EnsemblBacteria" id="ABB60974">
        <property type="protein sequence ID" value="ABB60974"/>
        <property type="gene ID" value="SDY_0792"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0792"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.915"/>
    <dbReference type="HOGENOM" id="CLU_145313_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015891">
        <property type="term" value="P:siderophore transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220856" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="110" mass="11704" checksum="916BF622E621582C" modified="2005-12-06" version="1">MENNRNFPARQFHSLTFFAGLCIGITPVAQALAAEGQANADDTLVVEASTPSLYAPQQSADPKFSRPVADTTRTMTVISEQVIKDQGATNLTDALKNVPGVGNADQLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IF0</accession>
    <name>Q32IF0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0585</name>
        <name evidence="4" type="ordered locus">SDY_0723</name>
        <name evidence="12" type="ordered locus">SDY_0849</name>
        <name evidence="5" type="ordered locus">SDY_0868</name>
        <name evidence="6" type="ordered locus">SDY_0931</name>
        <name evidence="7" type="ordered locus">SDY_1785</name>
        <name evidence="8" type="ordered locus">SDY_2361</name>
        <name evidence="9" type="ordered locus">SDY_2419</name>
        <name evidence="10" type="ordered locus">SDY_3195</name>
        <name evidence="11" type="ordered locus">SDY_4341</name>
    </gene>
    <organism evidence="4 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 13">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402274.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402396.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402519.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402537.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402597.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403390.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403929.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403983.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404696.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405723.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0585"/>
    <dbReference type="EnsemblBacteria" id="ABB60785">
        <property type="protein sequence ID" value="ABB60785"/>
        <property type="gene ID" value="SDY_0585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60907">
        <property type="protein sequence ID" value="ABB60907"/>
        <property type="gene ID" value="SDY_0723"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61046">
        <property type="protein sequence ID" value="ABB61046"/>
        <property type="gene ID" value="SDY_0868"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61106">
        <property type="protein sequence ID" value="ABB61106"/>
        <property type="gene ID" value="SDY_0931"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61899">
        <property type="protein sequence ID" value="ABB61899"/>
        <property type="gene ID" value="SDY_1785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62438">
        <property type="protein sequence ID" value="ABB62438"/>
        <property type="gene ID" value="SDY_2361"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62492">
        <property type="protein sequence ID" value="ABB62492"/>
        <property type="gene ID" value="SDY_2419"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63205">
        <property type="protein sequence ID" value="ABB63205"/>
        <property type="gene ID" value="SDY_3195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64232">
        <property type="protein sequence ID" value="ABB64232"/>
        <property type="gene ID" value="SDY_4341"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64514">
        <property type="protein sequence ID" value="ABB64514"/>
        <property type="gene ID" value="SDY_0849"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0585"/>
    <dbReference type="KEGG" id="sdy:SDY_0723"/>
    <dbReference type="KEGG" id="sdy:SDY_0849"/>
    <dbReference type="KEGG" id="sdy:SDY_0868"/>
    <dbReference type="KEGG" id="sdy:SDY_0931"/>
    <dbReference type="KEGG" id="sdy:SDY_1785"/>
    <dbReference type="KEGG" id="sdy:SDY_2361"/>
    <dbReference type="KEGG" id="sdy:SDY_2419"/>
    <dbReference type="KEGG" id="sdy:SDY_3195"/>
    <dbReference type="KEGG" id="sdy:SDY_4341"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1003"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="OMA" id="MNRIPRA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB64232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB64514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="11210" checksum="296102373CFE71F1" modified="2005-12-06" version="1">MSRKTQRYSKEFKAEAVRMVLENQLSISEGASRLSLPEGTLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKATAYFAQESLKNTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IH0</accession>
    <name>GPMA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="1">BPG-dependent PGAM</shortName>
            <shortName evidence="1">PGAM</shortName>
            <shortName evidence="1">Phosphoglyceromutase</shortName>
            <shortName evidence="1">dPGM</shortName>
            <ecNumber evidence="1">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmA</name>
        <name type="ordered locus">SDY_0702</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019991.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402376.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IH0"/>
    <dbReference type="SMR" id="Q32IH0"/>
    <dbReference type="STRING" id="300267.SDY_0702"/>
    <dbReference type="EnsemblBacteria" id="ABB60887">
        <property type="protein sequence ID" value="ABB60887"/>
        <property type="gene ID" value="SDY_0702"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0702"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.813"/>
    <dbReference type="HOGENOM" id="CLU_033323_1_1_6"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000229141" description="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <sequence length="250" mass="28484" checksum="A56D124CE6F8482A" modified="2005-12-06" version="1">MAVTKLVLVRHGESQWNKENRFTGWYDVDLSEKGVSEAKAAGKLLKEEGYSFDFAYTSVLKRAIHTLWNVLDELDQAWLPVEKSWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFAVTPPELTKDDERYPGHDPRYAKLSEKELPLTESLALTIDRVIPYWNETILPRMKSGERVIIAAHGNSLRALVKYLDNMSEEGILELNIPTGVPLVYEFDENFKPLKRYYLGNADEIAAKAAAVANQGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IM3</accession>
    <name>Q32IM3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybgI</name>
        <name evidence="4" type="ordered locus">SDY_0645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Toroid-shaped homohexamer. In the hexamer, 3 dimers assemble to form a ring-like structure surrounding a central hole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000798878.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402323.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IM3"/>
    <dbReference type="STRING" id="300267.SDY_0645"/>
    <dbReference type="EnsemblBacteria" id="ABB60834">
        <property type="protein sequence ID" value="ABB60834"/>
        <property type="gene ID" value="SDY_0645"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0645"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.753"/>
    <dbReference type="HOGENOM" id="CLU_037423_3_0_6"/>
    <dbReference type="OMA" id="HGLFWRG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="247" mass="26910" checksum="316CB8731A03581B" modified="2005-12-06" version="1">MKNTELEQLINEKLNSAAISDYAPNGLQVEGKETVQKIVTGVTASQALLDEAVRLGADAVIVHHGYFWKGESPVIRGMKRNRLKTLLANDINLYGWHLPLDAHPELGNNAQLAVLLGITVMGEIEPLVPWGELTMPVPGLELASWIEARLGRKSLWCGDTGPEVVQRVAWCTGGGQSFIDSAARFGVDAFITGEVSEQTIHSAREQGLHFYAAGHHATERGGIRALSEWLNENTDLDVTFIDIPNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IQ3</accession>
    <name>Q32IQ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nagA</name>
        <name evidence="8" type="ordered locus">SDY_0611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000271200.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402293.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IQ3"/>
    <dbReference type="STRING" id="300267.SDY_0611"/>
    <dbReference type="EnsemblBacteria" id="ABB60804">
        <property type="protein sequence ID" value="ABB60804"/>
        <property type="gene ID" value="SDY_0611"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0611"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.707"/>
    <dbReference type="HOGENOM" id="CLU_032482_2_2_6"/>
    <dbReference type="OMA" id="HAFNAMP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="50"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="306"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="382" mass="41006" checksum="8B676500EE8E6748" modified="2005-12-06" version="1">MYALTRGRIFTGHEFLDDHAVVIADGLIKSVCPVAELPPEIEQRSLNGAILSPGFIDVQLNGCGGVQFNDTAEAVSVETLEIMQKANEKSGCTNYLPTLITTSDELMKQGVRVMREYLAKHPNQALGLHLEGPWLNLVKKGTHNPNFVRKPDAALVDFLCENSDVITKVTLAPEMVPAEIISKLANAGIVVSAGHSNATLKEAKAGFRAGITFATHLYNAMPYITGREPGLAGAILDEADIYCGIIADGLHVDYANIRNAKRLKGNKLCLVTDATAPAGANIEQFIFAGKTIYYRNGLCVDENGTLSGSSLTMIEGVRNLVEHCGIALDEVLRMATLYPARAIGVEKRLGTLAAGKVANLTAFTPDFKITKTIVNGNEVVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IT2</accession>
    <name>Q32IT2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IT2"/>
    <dbReference type="EnsemblBacteria" id="ABB60775">
        <property type="protein sequence ID" value="ABB60775"/>
        <property type="gene ID" value="SDY_0571"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0571"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="78" mass="9103" checksum="2DB32C3B94702A95" modified="2005-12-06" version="1">MITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFGDAANLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IW4</accession>
    <name>Q32IW4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAPS_reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybdN</name>
        <name evidence="2" type="ordered locus">SDY_0537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402232.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IW4"/>
    <dbReference type="STRING" id="300267.SDY_0537"/>
    <dbReference type="EnsemblBacteria" id="ABB60743">
        <property type="protein sequence ID" value="ABB60743"/>
        <property type="gene ID" value="SDY_0537"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0537"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.633"/>
    <dbReference type="HOGENOM" id="CLU_036373_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="30"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="217" mass="25621" checksum="F62FEBFCDA40C88D" modified="2005-12-06" version="1">MSIYKIPLPLNILEAARERITWTLNTLPRVCVSFSGGKDSGLMLHLTAELARHMGKKICVLFIDWEAQFSCTINYVQSLRELYTDVIEEFYWVALPLTTQNSLSQYQPEWQCWEHDVEWVRQPPQDAITDPDFFCFYQPGMTFEQFVREFAEWFSQKRPAAMMIGIRADESYNRFVAIASLNKQRFADDKPWTTAAPGGHSWYIYPIYDWKVEVYWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IZ7</accession>
    <name>Q32IZ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Taurine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tauC</name>
        <name evidence="8" type="ordered locus">SDY_0503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000114603.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402199.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IZ7"/>
    <dbReference type="STRING" id="300267.SDY_0503"/>
    <dbReference type="EnsemblBacteria" id="ABB60710">
        <property type="protein sequence ID" value="ABB60710"/>
        <property type="gene ID" value="SDY_0503"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0503"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.594"/>
    <dbReference type="HOGENOM" id="CLU_046113_1_0_6"/>
    <dbReference type="OMA" id="LIEFYRP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="80"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="275" mass="29556" checksum="1F7BBC8FCA34B73D" modified="2005-12-06" version="1">MSVLINEKLHSRRLKWRWPLSRQVTLSIGTLAVLLTVWWTVAALQLISPLFLPPPQQVLAKLLTIAGPQGFMDATLWQHLAASLTRIVLALLAAVLIGIPVGISMGLSPTVRGILDPVIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMSALAGVKSAQQVRIRAAQSLGASRAQVLWFVILPGALPEILTGLRIGLGGGWSTLVAAELIAATRGLGFMVQSAGEFLATDVVLAGIAVIAIIAFLLELGLRALQRRLTPWHGEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J03</accession>
    <name>Q32J03_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402193.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J03"/>
    <dbReference type="STRING" id="300267.SDY_0497"/>
    <dbReference type="EnsemblBacteria" id="ABB60704">
        <property type="protein sequence ID" value="ABB60704"/>
        <property type="gene ID" value="SDY_0497"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0497"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.587"/>
    <dbReference type="HOGENOM" id="CLU_891085_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="330" mass="34808" checksum="855F9246BB2AD3EF" modified="2005-12-06" version="1">MTSLKTSIKTITYLSDTGCLEIQGASLEFDHITGNQVYQSGLFNVTLNTGSQWDITKTSLIDTLSINSGSTVNVADSTLISDSISLTGLSALNINEDGHVATDSLTVDNSTVTISDEVSAGWAVGDAALYANNIKVTNDGILDVGNTAANALQVDTLNLTSTTDTSGNIHAGVFNIESNRFVLDADLTNDRTNDTTKSNYGYGLIAMNSDGHLTINGNGDNDNTASIEAGQNEVDNNGDHVAAATGNYKVRIDNATGAGSIADYNGNELIYVNDKNSNATFSAVNKADLGAYTYQAEQRGNTVVLQQMELTDYANMALSIPSANTNIWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J07</accession>
    <name>Q32J07_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybdJ</name>
        <name evidence="2" type="ordered locus">SDY_0493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000682488.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402189.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J07"/>
    <dbReference type="STRING" id="300267.SDY_0493"/>
    <dbReference type="EnsemblBacteria" id="ABB60700">
        <property type="protein sequence ID" value="ABB60700"/>
        <property type="gene ID" value="SDY_0493"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0493"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.582"/>
    <dbReference type="HOGENOM" id="CLU_194433_0_0_6"/>
    <dbReference type="OMA" id="FVWRRWF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010590">
        <property type="entry name" value="DUF1158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06643">
        <property type="entry name" value="DUF1158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="9464" checksum="A9757EAC043D1D8F" modified="2005-12-06" version="1">MKHPLEILTTAAGIFLMAFLSCLLLPAPALGLTQAQKLVTTFHLMDLSQLYTLLFCLWFLVLGAIEYFVLRFIWRRWFSLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J60</accession>
    <name>Q32J60_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybaK</name>
        <name evidence="5" type="ordered locus">SDY_0437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000186627.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402136.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J60"/>
    <dbReference type="STRING" id="300267.SDY_0437"/>
    <dbReference type="EnsemblBacteria" id="ABB60647">
        <property type="protein sequence ID" value="ABB60647"/>
        <property type="gene ID" value="SDY_0437"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0437"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.518"/>
    <dbReference type="HOGENOM" id="CLU_094875_1_1_6"/>
    <dbReference type="OMA" id="PYDYVEH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="31"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="159" mass="17065" checksum="4C466A2239FDBA1E" modified="2005-12-06" version="1">MTPAVKLLEKNKISFQIHTYEHDPAETNFGDEVVKKLGLNPDQVYKTLLVAVNGDMKHLAVAVTPVAGQLDLKKVAKALGAKKVEMADPMAAQRSTGYLVGGISPLGQKKRLPTIIDAPAQEFATIYVSGGKRGLDIELAAGDLAKILDAKFADIARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JA0</accession>
    <name>Q32JA0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxylate carboligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gcl</name>
        <name evidence="6" type="ordered locus">SDY_0395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402096.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JA0"/>
    <dbReference type="STRING" id="300267.SDY_0395"/>
    <dbReference type="EnsemblBacteria" id="ABB60607">
        <property type="protein sequence ID" value="ABB60607"/>
        <property type="gene ID" value="SDY_0395"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0395"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.469"/>
    <dbReference type="HOGENOM" id="CLU_013748_1_1_6"/>
    <dbReference type="OMA" id="TLMGWGA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009028">
        <property type="term" value="F:tartronate-semialdehyde synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006397">
        <property type="entry name" value="Glyox_carbo_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF14">
        <property type="entry name" value="PTHR18968:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01504">
        <property type="entry name" value="glyox_carbo_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="193"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="393"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="519" mass="56865" checksum="F9A4230A95BA82AE" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JC6</accession>
    <name>Q32JC6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000763147.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402070.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JC6"/>
    <dbReference type="STRING" id="300267.SDY_0367"/>
    <dbReference type="EnsemblBacteria" id="ABB60581">
        <property type="protein sequence ID" value="ABB60581"/>
        <property type="gene ID" value="SDY_0367"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0367"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.434"/>
    <dbReference type="HOGENOM" id="CLU_180695_0_0_6"/>
    <dbReference type="OMA" id="FWAGAQI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020513">
        <property type="entry name" value="Uncharacterised_IM_YaiY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10954">
        <property type="entry name" value="DUF2755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="102" mass="11396" checksum="9497DD5AE0F88943" modified="2005-12-06" version="1">MADFTLSKSLFSGKYRNASSTPGNIAYALFVLFCFWAGAQLLNLLVHAPGVYERLMQVQETGRPRVEIGLGAGTIFGLIPFLVGCLIFAVVALWLHWRHRRQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JD6</accession>
    <name>YAII_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0178 protein YaiI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yaiI</name>
        <name type="ordered locus">SDY_0357</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0178 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60572" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60572.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000158159.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402060.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JD6"/>
    <dbReference type="STRING" id="300267.SDY_0357"/>
    <dbReference type="EnsemblBacteria" id="ABB60572">
        <property type="protein sequence ID" value="ABB60572"/>
        <property type="gene ID" value="SDY_0357"/>
    </dbReference>
    <dbReference type="GeneID" id="66671314"/>
    <dbReference type="KEGG" id="sdy:SDY_0357"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.417"/>
    <dbReference type="HOGENOM" id="CLU_106619_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00489">
        <property type="entry name" value="UPF0178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003791">
        <property type="entry name" value="UPF0178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35146">
        <property type="entry name" value="PTHR35146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02639">
        <property type="entry name" value="DUF188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000241831" description="UPF0178 protein YaiI">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="152" mass="16969" checksum="51DAF86CE9E5D05B" modified="2006-06-27" version="2">MTIWVDADACPNVIKEILYRAAERMQMPLVLVANQSLRVPPSRFIRTLRVAAGFDVADNEIVRQCEAGDLVITADIPLAAEAIEKGAAALNPRGERYTPATIRERLTMRDFMDTLRASGIQTGGPDSLSQRDRQAFAAELEKWWLEVQRSRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JK2</accession>
    <name>QUEC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.4.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queC</name>
        <name type="ordered locus">SDY_0286</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000817241.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401994.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JK2"/>
    <dbReference type="SMR" id="Q32JK2"/>
    <dbReference type="STRING" id="300267.SDY_0286"/>
    <dbReference type="EnsemblBacteria" id="ABB60505">
        <property type="protein sequence ID" value="ABB60505"/>
        <property type="gene ID" value="SDY_0286"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0286"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.331"/>
    <dbReference type="HOGENOM" id="CLU_081854_0_0_6"/>
    <dbReference type="OMA" id="CESCMRR"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01633">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00364">
        <property type="entry name" value="TIGR00364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000246923" description="7-cyano-7-deazaguanine synthase">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01633"/>
        </source>
    </evidence>
    <sequence length="231" mass="25474" checksum="546872267E6E310E" modified="2005-12-06" version="1">MKRAVVVFSGGQDSTTCLVQALQQYDEVHCVTFDYGQRHRAEIDVARELALKLGARAHKVLDVTLLNELAVSSLTRDSIPVPDYEPEADGIPNTFVPGRNILFLTLAAIYAYQVKAEAVITGVCETDFSGYPDCRDEFVKALNHAVSLGMAKHIRFETPLMWIDKAETWALADYYGKLDLVRNETLTCYNGIKGDGCGHCAACNLRANGLNHYLADKPTVMAAMKQKTGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JR6</accession>
    <name>Q32JR6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RF_PROK_I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yaeJ</name>
        <name evidence="4" type="ordered locus">SDY_0210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000635559.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401930.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JR6"/>
    <dbReference type="STRING" id="300267.SDY_0210"/>
    <dbReference type="EnsemblBacteria" id="ABB60441">
        <property type="protein sequence ID" value="ABB60441"/>
        <property type="gene ID" value="SDY_0210"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0210"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.244"/>
    <dbReference type="HOGENOM" id="CLU_089470_3_0_6"/>
    <dbReference type="OMA" id="SEHRSQW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="140" mass="15673" checksum="BCDF66A3AA1C60AA" modified="2005-12-06" version="1">MIVISRHVAIPDGELEITAIRAQGVGGQHVNKTSTAIHLRFDIRASSLPEYYKERLLAASYHLISSDGVIVIKAQEYRSQELNREAALARLVAVIKELTTEQKVRRPTRPTRASKERRLASKAQKSSVKAMRGKVRSGRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JV2</accession>
    <name>ERPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Iron-sulfur cluster insertion protein ErpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">erpA</name>
        <name type="ordered locus">SDY_0172</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for insertion of 4Fe-4S clusters for at least IspG.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
        <text evidence="1">Binds 1 iron-sulfur cluster per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295564.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401894.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JV2"/>
    <dbReference type="SMR" id="Q32JV2"/>
    <dbReference type="STRING" id="300267.SDY_0172"/>
    <dbReference type="EnsemblBacteria" id="ABB60405">
        <property type="protein sequence ID" value="ABB60405"/>
        <property type="gene ID" value="SDY_0172"/>
    </dbReference>
    <dbReference type="GeneID" id="67416233"/>
    <dbReference type="KEGG" id="sdy:SDY_0172"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.198"/>
    <dbReference type="HOGENOM" id="CLU_069054_5_3_6"/>
    <dbReference type="OMA" id="YQLYFDE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01380">
        <property type="entry name" value="Fe_S_insert_ErpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023063">
        <property type="entry name" value="FeS_cluster_insertion_RrpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000311560" description="Iron-sulfur cluster insertion protein ErpA">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01380"/>
        </source>
    </evidence>
    <sequence length="114" mass="12100" checksum="5A032FB5C3E0D04A" modified="2005-12-06" version="1">MSDDVALPLEFTDAAANKVKSLIADEDNPNLKLRVYITGGGCSGFQYGFTFDDQVNEGDMTIEKQGVGLVVDPMSLQYLVGGSVDYTEGLEGSRFIVTNPNAKSTCGCGSSFSI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JY9</accession>
    <name>COAE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name type="ordered locus">SDY_0133</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001269520.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401857.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JY9"/>
    <dbReference type="SMR" id="Q32JY9"/>
    <dbReference type="STRING" id="300267.SDY_0133"/>
    <dbReference type="EnsemblBacteria" id="ABB60368">
        <property type="protein sequence ID" value="ABB60368"/>
        <property type="gene ID" value="SDY_0133"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0133"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.151"/>
    <dbReference type="HOGENOM" id="CLU_057180_1_2_6"/>
    <dbReference type="OMA" id="QMDIEQK"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000243340" description="Dephospho-CoA kinase">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DPCK" evidence="1">
        <location>
            <begin position="4"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <sequence length="206" mass="22622" checksum="41C69353B4EFF871" modified="2005-12-06" version="1">MRYIVALTGGIGSGKSTVANAFADLGINVIDADIIARQVVEPGAPALHAIADHFGANMIAADGTLQRRALRERIFANPEEKNWLNALLHPLIQQETQHQIQQATSPYVLWVVPLLVENSLYKKANRVLVVDVSPETQLKRTMQRDDVTREHVEQILAAQATREARLAVADDVIDNNGAPDAIASDVARLHAHYLQLASQFVSQEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q326N8</accession>
    <name>Q326N8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS3 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406208.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326N8"/>
    <dbReference type="EnsemblBacteria" id="ABB64720">
        <property type="protein sequence ID" value="ABB64720"/>
        <property type="gene ID" value="SDY_P207"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P207"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5761"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_12_6"/>
    <dbReference type="OMA" id="EAFHWAK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038965">
        <property type="entry name" value="InsF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46889:SF1">
        <property type="entry name" value="PTHR46889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="80" mass="8776" checksum="F1640BA2751AA0D9" modified="2005-12-06" version="1">MCSGYHFNVKTVAASLRRQELSAKASQKFSPISYRAHGLPVSENLLTQDFYASGPNQKWAGDITYYYSSPTAGKHGAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q326P9</accession>
    <name>Q326P9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS3 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406197.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326P9"/>
    <dbReference type="EnsemblBacteria" id="ABB64709">
        <property type="protein sequence ID" value="ABB64709"/>
        <property type="gene ID" value="SDY_P196"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P196"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5748"/>
    <dbReference type="HOGENOM" id="CLU_1814513_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038965">
        <property type="entry name" value="InsF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46889:SF1">
        <property type="entry name" value="PTHR46889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="2">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="142" mass="16202" checksum="0EEF12B4AB5D3477" modified="2005-12-06" version="1">MNWPLKMPPEAATGGAGRGTGYPPKGRDILCEAPEMKYIFIEKHQAEFSIKAMCRVLRVARSGWYTWCQRRTGISPRQQFRQHCDSVVLSAAFTRSKQRYGAPRLTDELRAPGYHFNVKTVAASLRRQGLSWNLKLCNCVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q326S3</accession>
    <name>Q326S3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ipgE</name>
        <name evidence="6" type="ordered locus">SDY_P172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Sd197</strain>
            <plasmid evidence="7">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the IpgE/SigE chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000389733.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406173.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326S3"/>
    <dbReference type="EnsemblBacteria" id="ABB64685">
        <property type="protein sequence ID" value="ABB64685"/>
        <property type="gene ID" value="SDY_P172"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P172"/>
    <dbReference type="HOGENOM" id="CLU_2048158_0_0_6"/>
    <dbReference type="OMA" id="DDEIQVY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17022">
        <property type="entry name" value="T3SC_IA_SigE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013095">
        <property type="entry name" value="T3SS_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07824">
        <property type="entry name" value="Chaperone_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034754">
        <property type="entry name" value="T3SS_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR034754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="120" mass="13682" checksum="0CF9C97F55AA90CE" modified="2005-12-06" version="1">MEDLADVICRALGIPSIDTDDQAIMLDDDVLIYIEKEGDSINLLCPFCALPENINDLIYALSLNYSEKICLATDDEGGSLIARLDLTGINEFEDIYVNTEYYISRVRWLKDEFARRMKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q326V8</accession>
    <name>Q326V8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Replication initiation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">repA</name>
        <name evidence="2" type="ordered locus">SDY_P137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000130974.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406138.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326V8"/>
    <dbReference type="EnsemblBacteria" id="ABB64650">
        <property type="protein sequence ID" value="ABB64650"/>
        <property type="gene ID" value="SDY_P137"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P137"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5694"/>
    <dbReference type="HOGENOM" id="CLU_075525_0_0_6"/>
    <dbReference type="OMA" id="RFDFSIH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006276">
        <property type="term" value="P:plasmid maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017837">
        <property type="entry name" value="Plasmid_rep_init_RepA_IncFII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003446">
        <property type="entry name" value="Plasmid_replication_init_RepA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02387">
        <property type="entry name" value="IncFII_repA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03474">
        <property type="entry name" value="incFII_RepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="285" mass="32760" checksum="34C5DE9882175B81" modified="2005-12-06" version="1">MTDLQQTYYRQVKNPNPVFTPREGARTLPFCGKLMEKAVGFTSRFDFAIHVAHARSLGLRRRMPPVLRRRAIDALLQGLCFHYDPLANRVQCSITTLAIECGLATESDAGTLSITRATRALTFLAELGLITYQTEYDPLIGCNIPTDITFTPALFAALDVSEEAVASARRSRVEWENRQRKKQGLDTLGMDELMAKAWRFVRERFRSYQTELKSRGMKRARARRDADRQRQDIVTLVKRQLTREISEGRFTASREAVKREVERRVKERMILSRNRNYSRLATASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q327C0</accession>
    <name>Q327C0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stable inheritance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">stbA</name>
        <name evidence="2" type="ordered locus">SDY_P075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000921950.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406076.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327C0"/>
    <dbReference type="EnsemblBacteria" id="ABB64588">
        <property type="protein sequence ID" value="ABB64588"/>
        <property type="gene ID" value="SDY_P075"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P075"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5623"/>
    <dbReference type="HOGENOM" id="CLU_074773_0_1_6"/>
    <dbReference type="OMA" id="YDATSDK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="CDD" id="cd10227">
        <property type="entry name" value="ParM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042051">
        <property type="entry name" value="ParM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009440">
        <property type="entry name" value="Plasmid_segregation_ParM/StbA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06406">
        <property type="entry name" value="StbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="StbA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="319" mass="35649" checksum="E8EB58C8FEBA730B" modified="2005-12-06" version="1">MLKVSCDDGSTNVKLAWLEDGEVRTSLSGNSFKEGWNPGLFNAGKVYNYVVDEKKYTYDLGSTAVIGTTHVSYQYSTTNLLAIHHALLTSGLQPQDVELTVTLPVTEFFDNDNQPNEERIERKKANVLREISLNKGETFKIKKVNVMPESLPAAFELLKKDKVNKLERSLIIDLGGTTLDCGLILGAFEGISEIRGYSEIGTSRITHTVMNALTKASTPCNYFIADELIKNRHDNEYLQTLINDVAEIKNISHVIDREVKSLAESIRQEISTFSGMNRIYLTGGGAELIYPHIKQYFPNLKVNKVDEPQFALVKAMVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q327E5</accession>
    <name>Q327E5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iso-IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_P050</name>
        <name evidence="9" type="ordered locus">SDY_P058</name>
        <name evidence="10" type="ordered locus">SDY_P095</name>
        <name evidence="11" type="ordered locus">SDY_P213</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 12">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="8 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Sd197</strain>
            <plasmid evidence="12">Plasmid pSD1_197</plasmid>
            <plasmid evidence="8">pSD1_197</plasmid>
            <plasmid evidence="8">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Sd197</strain>
            <plasmid evidence="8">pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000618.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000619.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000620.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000621.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000623.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000625.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000626.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000628.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000629.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000630.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000632.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000634.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000635.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000637.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000638.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000641.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000642.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000643.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000647.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000651.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000652.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000653.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000655.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000656.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000659.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000661.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000662.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000666.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000674.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000675.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000676.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000677.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000679.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000680.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000681.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000682.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000683.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000685.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000686.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000689.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000691.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000692.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000694.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000695.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000696.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000697.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000701.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000702.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000703.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000704.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000705.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000706.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000708.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000709.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000710.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000713.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000715.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000717.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000719.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000722.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000723.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000724.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000725.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000726.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000729.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000730.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000731.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000732.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000734.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000737.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000739.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
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        <property type="gene ID" value="SDY_P050"/>
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        <property type="protein sequence ID" value="ABB64571"/>
        <property type="gene ID" value="SDY_P058"/>
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        <property type="protein sequence ID" value="ABB64608"/>
        <property type="gene ID" value="SDY_P095"/>
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        <property type="protein sequence ID" value="ABB64726"/>
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    <dbReference type="PATRIC" id="fig|300267.13.peg.5594"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_0_6"/>
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    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB64726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="10348" checksum="810D546B26572C63" modified="2005-12-06" version="1">MASVNIHCPRCQSAQVYRHGQNPKGHDRFRCRDCHRVFQLTYTYEARKPGIKELITEMAFNGAGVRDTARTLKIGINTVIRTLKNSRQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q327K1</accession>
    <name>Q327K1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/xanthosine triphosphatase</fullName>
            <shortName evidence="4">ITPase/XTPase</shortName>
            <ecNumber evidence="4">3.6.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Non-canonical purine NTP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Non-standard purine NTP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Nucleoside-triphosphate phosphatase</fullName>
            <shortName evidence="4">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yjjX</name>
        <name evidence="6" type="ordered locus">SDY_4655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + ITP = H(+) + IDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28330"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58280"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + XTP = H(+) + phosphate + XDP</text>
            <dbReference type="Rhea" id="RHEA:28406"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59884"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YjjX NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.73" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327K1"/>
    <dbReference type="STRING" id="300267.SDY_4655"/>
    <dbReference type="EnsemblBacteria" id="ABB64504">
        <property type="protein sequence ID" value="ABB64504"/>
        <property type="gene ID" value="SDY_4655"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4655"/>
    <dbReference type="HOGENOM" id="CLU_087417_1_0_6"/>
    <dbReference type="OMA" id="ADYWVGI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103023">
        <property type="term" value="F:ITPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00648">
        <property type="entry name" value="Non_canon_purine_NTPase_YjjX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002786">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00258">
        <property type="entry name" value="TIGR00258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTPase_I-T" evidence="5">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="173" mass="18657" checksum="F03DC180512837A5" modified="2005-12-06" version="1">MLIMHQVVCATTNPAKIQAILQAFHEIFGEGSCHIASVAVESGVPEQPFGSEETRAGARNRVANARRLLPEADFWVAIEAGIDDDSTFSWVVIENTSQRGEARSATLPLPAVILQKVREGEALGPVMSRYTGIDEIGRKEGAIGVFTAGKLTRASVYHQAVILALSPFHNAVY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q328H2</accession>
    <name>FRDC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fumarate reductase subunit C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Fumarate reductase 15 kDa hydrophobic protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Quinol-fumarate reductase subunit C</fullName>
            <shortName evidence="1">QFR subunit C</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frdC</name>
        <name type="ordered locus">SDY_4396</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FrdC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000208755.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405774.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328H2"/>
    <dbReference type="SMR" id="Q328H2"/>
    <dbReference type="STRING" id="300267.SDY_4396"/>
    <dbReference type="EnsemblBacteria" id="ABB64283">
        <property type="protein sequence ID" value="ABB64283"/>
        <property type="gene ID" value="SDY_4396"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4396"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5192"/>
    <dbReference type="HOGENOM" id="CLU_156492_0_0_6"/>
    <dbReference type="OMA" id="MTATWWQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045284">
        <property type="term" value="C:plasma membrane fumarate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00546">
        <property type="entry name" value="QFR_TypeD_subunitC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00708">
        <property type="entry name" value="Fumarate_red_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003510">
        <property type="entry name" value="Fumarate_red_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02300">
        <property type="entry name" value="Fumarate_red_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000180">
        <property type="entry name" value="FrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000045533" description="Fumarate reductase subunit C">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00708"/>
        </source>
    </evidence>
    <sequence length="131" mass="14997" checksum="26FDF83E6EBCEF43" modified="2005-12-06" version="1">MTTKRKPYVRPMTSTWWKKLPFYRFYMLREGTAVPAVWFSIELIFGLFALKNGPEAWAGFVDFLQNPVIVIINLITLAAALLHTKTWFELAPKAANIIVKDEKIGPEPIIKSLWAVTVVATIVILFVALYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q328M4</accession>
    <name>Q328M4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">O-acetyltransferase WecH</fullName>
            <ecNumber evidence="1">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yiaH</name>
        <name evidence="1" type="synonym">wecH</name>
        <name evidence="3" type="ordered locus">SDY_4340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001182641.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405722.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328M4"/>
    <dbReference type="STRING" id="300267.SDY_4340"/>
    <dbReference type="EnsemblBacteria" id="ABB64231">
        <property type="protein sequence ID" value="ABB64231"/>
        <property type="gene ID" value="SDY_4340"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4340"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5124"/>
    <dbReference type="HOGENOM" id="CLU_047714_3_0_6"/>
    <dbReference type="OMA" id="TFYYVLY"/>
    <dbReference type="UniPathway" id="UPA00566"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009246">
        <property type="term" value="P:enterobacterial common antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01949">
        <property type="entry name" value="Acetyltr_WecH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032905">
        <property type="entry name" value="WecH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="332" mass="37786" checksum="563F8FF4C2DCB422" modified="2005-12-06" version="1">MQPKIYWIDNLRGIACLMVVMIHTTTWYVTNAHSVSPVTWDIANVLNSASRVSVPLFFMISGYLFFGERSAQPRHFLRIGLCLFFYSAIALLYIALFTSINVELALKNLLQKPVFYHLWFFFAIAVIYLVSPLIQVKNVGGKMLLVLMVVIGIIANPNTVPQKIDGFEWLPINLYINGDTFYYILYGMLGRAIGMMDTQHKALSWVSAALFATGVFIISRGTLYELQWRGNFADTWYLYCGPMVFICAIALLTLVKNTLDTRTIRGLGLISRHSLGIYGFHALIIHALRTRGIELKNWPILDIIWIFCATLAASLLLSMLVQRIDRNRLVSW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q328V4</accession>
    <name>F16PA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-1,6-bisphosphatase class 1</fullName>
            <shortName evidence="1">FBPase class 1</shortName>
            <ecNumber evidence="1">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbp</name>
        <name type="ordered locus">SDY_4250</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000853753.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405642.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328V4"/>
    <dbReference type="SMR" id="Q328V4"/>
    <dbReference type="STRING" id="300267.SDY_4250"/>
    <dbReference type="EnsemblBacteria" id="ABB64151">
        <property type="protein sequence ID" value="ABB64151"/>
        <property type="gene ID" value="SDY_4250"/>
    </dbReference>
    <dbReference type="GeneID" id="66671851"/>
    <dbReference type="KEGG" id="sdy:SDY_4250"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5011"/>
    <dbReference type="HOGENOM" id="CLU_039977_2_2_6"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="PTHR11556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000364718" description="Fructose-1,6-bisphosphatase class 1">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="257"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01855"/>
        </source>
    </evidence>
    <sequence length="332" mass="36834" checksum="4F0FC8109491D78F" modified="2005-12-06" version="1">MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGEVQQKLDLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q328V5</accession>
    <name>Q328V5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yjfF</name>
        <name evidence="8" type="ordered locus">SDY_4249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405641.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328V5"/>
    <dbReference type="STRING" id="300267.SDY_4249"/>
    <dbReference type="EnsemblBacteria" id="ABB64150">
        <property type="protein sequence ID" value="ABB64150"/>
        <property type="gene ID" value="SDY_4249"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4249"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5010"/>
    <dbReference type="HOGENOM" id="CLU_028880_3_3_6"/>
    <dbReference type="OMA" id="IGFWGIS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="323" mass="34025" checksum="74542F5ECCE23504" modified="2005-12-06" version="1">MITIGVFVLGYLYCLTQFPGFASTRVICNILTDNAFLGIIAVGMTFVILSGGIDLSVGSVIAFTGVFLAKVIGDFGLSPLLAFPLVLVMGCAFGAFMGLLIDALKIPAFIITLAGMFFLRGVSYLVSEESIPINHPVYDTLSSLAWKIPGGGRLSAMGLLMLAVVVIGIFLAHRTRFGNQVYAIGGNATSANLMGISTRSTTIRIYMLSTGLATLAGIVFSIYTQAGYALAGVGVELDAIASVVIGGTLLSGGVGTVLGTLFGVAIQGLIQTYINFDGTLSSWWTKIAIGILLFIFIALQRGLTVLWENRQSSPVTRVNIAQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q329S4</accession>
    <name>ATPD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit delta</fullName>
            <shortName evidence="1">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpH</name>
        <name type="ordered locus">SDY_4013</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001288590.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405422.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329S4"/>
    <dbReference type="SMR" id="Q329S4"/>
    <dbReference type="STRING" id="300267.SDY_4013"/>
    <dbReference type="EnsemblBacteria" id="ABB63931">
        <property type="protein sequence ID" value="ABB63931"/>
        <property type="gene ID" value="SDY_4013"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4013"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4726"/>
    <dbReference type="HOGENOM" id="CLU_085114_3_0_6"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000371140" description="ATP synthase subunit delta">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <sequence length="177" mass="19362" checksum="7ABC8103E288C0A1" modified="2005-12-06" version="1">MSEFITVARPYAKAAFDFAVEHQSVERWQDMLAFAAEVTKNEQMAELLSGALAPETLAESFIAVCGEQLDENSQNLIRVMAENGRLNALPDVLEQFIHLRAVSEATAEVDVISAAALSEQQLAKISAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLERLADVLQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A20</accession>
    <name>FADA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="1">2.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetyl-CoA acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-ketothiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Fatty acid oxidation complex subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fadA</name>
        <name type="ordered locus">SDY_3900</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000438731.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405326.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A20"/>
    <dbReference type="SMR" id="Q32A20"/>
    <dbReference type="STRING" id="300267.SDY_3900"/>
    <dbReference type="EnsemblBacteria" id="ABB63835">
        <property type="protein sequence ID" value="ABB63835"/>
        <property type="gene ID" value="SDY_3900"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3900"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4608"/>
    <dbReference type="HOGENOM" id="CLU_031026_2_3_6"/>
    <dbReference type="OMA" id="EPMRPGT"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01620">
        <property type="entry name" value="FadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012805">
        <property type="entry name" value="FadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02445">
        <property type="entry name" value="fadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000292909" description="3-ketoacyl-CoA thiolase">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01620"/>
        </source>
    </evidence>
    <sequence length="387" mass="40855" checksum="0C0A1ABFE8D6D18D" modified="2005-12-06" version="1">MEQVVIVDAIRTPMGRSKGGAFRNVRAEDLSAHLMRSLLARNPALEAAALDDIYWGCVQQTLEQGFNIARNAALLAEVPHSVPAVTVNRLCGSSMQALHDAARMIMTGDAQACLVGGVEHMGHVPMSHGVDFHPGLSRNVAKAAGMMGLTAEMLARMHGISREMQDAFAARSHARAWAATQSAAFKNEIIPTGGHDADGVLKQFNYDEVIRPETTVEALATLRPAFDPVNGTVTAGTSSALSDGAAAMLVMSESRAHELGLKPRARVRSMAVVGCDPSIMGYGPVPASKLALKKAGLSVSDIGVFEMNEAFAAQILPCIKDLGLIEQIDEKINLNGGAIALGHPLGCSGARISTTLLNLMEHKDVQFGLATMCIGLGQGIATVFERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A54</accession>
    <name>Q32A54_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A54"/>
    <dbReference type="STRING" id="300267.SDY_3859"/>
    <dbReference type="EnsemblBacteria" id="ABB63801">
        <property type="protein sequence ID" value="ABB63801"/>
        <property type="gene ID" value="SDY_3859"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3859"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27553" checksum="73FE187FA6919B71" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQKQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHHMSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-23" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A84</accession>
    <name>TPIS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Triosephosphate isomerase</fullName>
            <shortName evidence="1">TIM</shortName>
            <shortName evidence="1">TPI</shortName>
            <ecNumber evidence="1">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tpiA</name>
        <name type="ordered locus">SDY_3826</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001216325.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405262.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A84"/>
    <dbReference type="SMR" id="Q32A84"/>
    <dbReference type="STRING" id="300267.SDY_3826"/>
    <dbReference type="EnsemblBacteria" id="ABB63771">
        <property type="protein sequence ID" value="ABB63771"/>
        <property type="gene ID" value="SDY_3826"/>
    </dbReference>
    <dbReference type="GeneID" id="66672173"/>
    <dbReference type="KEGG" id="sdy:SDY_3826"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4518"/>
    <dbReference type="HOGENOM" id="CLU_024251_2_1_6"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000307561" description="Triosephosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <sequence length="255" mass="26972" checksum="E398251020012D94" modified="2005-12-06" version="1">MRHPLVMGNWKLNGSRHMVHELVSNLRKELAGVAGCAVAIAPPEMYIDMAKREAEGSHIMLGAQNVDLNLSGAFTGETSAAMLKDIGAQYIIIGHSERRTYHKESDELIAKKFAVLKEQGLTPVLCIGETEAENEAGKTEEVCARQIDAVLKTQGAAAFEGAVIAYEPVWAIGTGKSATPAQAQAVHKFIRDHIAKVDANIAEQVIIQYGGSVNASNAAELFAQPDIDGALVGGASLKADAFAVIVKAAEAAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AC9</accession>
    <name>Q32AC9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-6-phosphate aldolase</fullName>
            <ecNumber evidence="7">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">talC</name>
        <name evidence="7" type="synonym">fsa</name>
        <name evidence="8" type="ordered locus">SDY_3781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodecamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transaldolase family. Type 3A subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000424853.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405217.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AC9"/>
    <dbReference type="STRING" id="300267.SDY_3781"/>
    <dbReference type="EnsemblBacteria" id="ABB63726">
        <property type="protein sequence ID" value="ABB63726"/>
        <property type="gene ID" value="SDY_3781"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3781"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4471"/>
    <dbReference type="HOGENOM" id="CLU_079764_2_0_6"/>
    <dbReference type="OMA" id="QQMLGTP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00496">
        <property type="entry name" value="F6P_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023001">
        <property type="entry name" value="F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="220" mass="23483" checksum="694F16FFD4CC090B" modified="2005-12-06" version="1">MELYLDTANVAEVERLARIFPIAGVTTNPSIIAASKESIWEVLPRLQKAIGDEGILFAQTMSRDAQGMVEEAKRLRDTIPGIVVKIPVTSEGLAAIKILKKEGITTLGTAVYSAAQGLLAALAGAKYVAPYVNRVDAQGGDGIRTVQGLQALLEMHAPESMVLAASFKTPRQALDCLLAGCESITLPLDVAQQMLNTPAVESAIEKFEHDWNAAFGTTHL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AF0</accession>
    <name>COAA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantothenate kinase</fullName>
            <ecNumber evidence="1">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaA</name>
        <name type="ordered locus">SDY_3754</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000023084.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405196.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AF0"/>
    <dbReference type="SMR" id="Q32AF0"/>
    <dbReference type="STRING" id="300267.SDY_3754"/>
    <dbReference type="EnsemblBacteria" id="ABB63705">
        <property type="protein sequence ID" value="ABB63705"/>
        <property type="gene ID" value="SDY_3754"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3754"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4445"/>
    <dbReference type="HOGENOM" id="CLU_053818_1_1_6"/>
    <dbReference type="OMA" id="RKYTQVS"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02025">
        <property type="entry name" value="PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00215">
        <property type="entry name" value="Pantothen_kinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004566">
        <property type="entry name" value="PanK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285:SF139">
        <property type="entry name" value="PTHR10285:SF139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000545">
        <property type="entry name" value="Pantothenate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00554">
        <property type="entry name" value="panK_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000043258" description="Pantothenate kinase">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00215"/>
        </source>
    </evidence>
    <sequence length="316" mass="36288" checksum="DDDC1922C5C69C90" modified="2005-12-06" version="1">MSIKEQTLMTPYLQFDRNQWAALRDSVPMTLSEDEIARLKGINEDLSLEEVAEIYLPLSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALLSRWPEHRRVELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVTAPVYSHLIYDVIPDGDKTVVQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTDPDSYFHNYAKLTKEEAIKTAMTLWKEINWLNLKQNILPTRGRASLILTKSANHAVEEVRLRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AK1</accession>
    <name>AROB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate synthase</fullName>
            <shortName evidence="1">DHQS</shortName>
            <ecNumber evidence="1">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroB</name>
        <name type="ordered locus">SDY_3690</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000439843.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405145.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AK1"/>
    <dbReference type="SMR" id="Q32AK1"/>
    <dbReference type="STRING" id="300267.SDY_3690"/>
    <dbReference type="EnsemblBacteria" id="ABB63654">
        <property type="protein sequence ID" value="ABB63654"/>
        <property type="gene ID" value="SDY_3690"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3690"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4378"/>
    <dbReference type="HOGENOM" id="CLU_001201_0_2_6"/>
    <dbReference type="OMA" id="YGVIWDA"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000231126" description="3-dehydroquinate synthase">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="169"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <sequence length="362" mass="38904" checksum="D5B0B25EAD596BDE" modified="2005-12-06" version="1">MERIVVTLGERSYPITIASGLFNEPASFLPLKSGEQVMLVTNETLAPLYLDKVRGVLEQAGVNVDSVILPDGEQYKSLAVLDTVFTALLQKPHGRDTTLVALGGGVVGDLTGFAAASYQRGVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPASVVVDLDCLKTLPPRELASGLAEVIKYGIILDGAFFNWLEEHLDALLRLDGPAMAYCIRRCCELKAEVVAADERETGLRALLNLGHTFGHAIEAEMGYGNWLHGEAVAAGMVMAARTSERLGQFSSAETQRIITLLKRAGLPVNGPREMSAQAYLPHMLRDKKVLAGEMRLILPLAIGKSEVRSGVSHELVLNAIADCQSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AN6</accession>
    <name>GLPG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhomboid protease GlpG</fullName>
            <ecNumber evidence="1">3.4.21.105</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Intramembrane serine protease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glpG</name>
        <name type="ordered locus">SDY_3651</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Rhomboid-type serine protease that catalyzes intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000928722.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405110.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AN6"/>
    <dbReference type="SMR" id="Q32AN6"/>
    <dbReference type="STRING" id="300267.SDY_3651"/>
    <dbReference type="MEROPS" id="S54.016"/>
    <dbReference type="EnsemblBacteria" id="ABB63619">
        <property type="protein sequence ID" value="ABB63619"/>
        <property type="gene ID" value="SDY_3651"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3651"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4333"/>
    <dbReference type="HOGENOM" id="CLU_058989_0_0_6"/>
    <dbReference type="OMA" id="LLGHCWI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01594">
        <property type="entry name" value="Rhomboid_GlpG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038236">
        <property type="entry name" value="GlpG_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022732">
        <property type="entry name" value="Peptidase_S54_GlpG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023662">
        <property type="entry name" value="Rhomboid_protease_GlpG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12122">
        <property type="entry name" value="Rhomboid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04239">
        <property type="entry name" value="rhombo_GlpG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000321694" description="Rhomboid protease GlpG">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01594"/>
        </source>
    </evidence>
    <sequence length="276" mass="31277" checksum="7B367D1E8E98D8FC" modified="2005-12-06" version="1">MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPALKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AR4</accession>
    <name>TUSA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfur carrier protein TusA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sulfur mediator TusA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sulfur transfer protein TusA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA 2-thiouridine synthesizing protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tusA</name>
        <name type="ordered locus">SDY_3621</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with IscS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000130621.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405082.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AR4"/>
    <dbReference type="SMR" id="Q32AR4"/>
    <dbReference type="STRING" id="300267.SDY_3621"/>
    <dbReference type="EnsemblBacteria" id="ABB63591">
        <property type="protein sequence ID" value="ABB63591"/>
        <property type="gene ID" value="SDY_3621"/>
    </dbReference>
    <dbReference type="GeneID" id="67417100"/>
    <dbReference type="KEGG" id="sdy:SDY_3621"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4297"/>
    <dbReference type="HOGENOM" id="CLU_165255_5_0_6"/>
    <dbReference type="OMA" id="FCQFLGH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03423">
        <property type="entry name" value="SirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00413">
        <property type="entry name" value="Thiourid_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022931">
        <property type="entry name" value="Sulphur_carrier_TusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000234125" description="Sulfur carrier protein TusA">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00413"/>
        </source>
    </evidence>
    <sequence length="81" mass="9095" checksum="63AA7DE4816A3274" modified="2005-12-06" version="1">MTDLFSSPDHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPGFCTFMEHELVAKETDGLPYRYLIRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AR6</accession>
    <name>Q32AR6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhhM</name>
        <name evidence="2" type="ordered locus">SDY_3618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000042878.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405080.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AR6"/>
    <dbReference type="STRING" id="300267.SDY_3618"/>
    <dbReference type="EnsemblBacteria" id="ABB63589">
        <property type="protein sequence ID" value="ABB63589"/>
        <property type="gene ID" value="SDY_3618"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3618"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4294"/>
    <dbReference type="HOGENOM" id="CLU_160683_0_0_6"/>
    <dbReference type="OMA" id="YHQLTVG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019635">
        <property type="entry name" value="DUF2500"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10694">
        <property type="entry name" value="DUF2500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13541" checksum="F7C749103F07A0EE" modified="2005-12-06" version="1">MSKPPLFFIVIIGLIIVAASFRFMQQRREKADNDMAPLQQKLVVVSNKREKPINDRRSRQQEVIPAGTSMRYEASFKPQSGGMEQTFRLDAQQYHALTVGDKGTLSYKGTRFVSFVGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AU2</accession>
    <name>Q32AU2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of gluconate operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gntR</name>
        <name evidence="5" type="ordered locus">SDY_3589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405054.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AU2"/>
    <dbReference type="STRING" id="300267.SDY_3589"/>
    <dbReference type="EnsemblBacteria" id="ABB63563">
        <property type="protein sequence ID" value="ABB63563"/>
        <property type="gene ID" value="SDY_3589"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3589"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4262"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_3_6"/>
    <dbReference type="OMA" id="MVFVDRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="312" mass="34284" checksum="FD6194351A889B3D" modified="2005-12-06" version="1">MTVSRFLRNPEQVSVALRGKIAAALDELGYIPNRAPDILSNATSRAIGVLLPSLTNQVFAEVLRGIESVTDAHGYQTMLAHYGYKPEMEQERLESMLSWNIDGLILTERTHTPRTLKMIEVAGIPVVELMDSKSPCLDIAVGFDNFEAARQMTAAIIARGHRHIAYLGARLDERTIIKQKGYEQAMRDAGLVPYSVMVEQSSSYSSGIELIRQARREYPQLDGVFCTNDDLAVGAAFECQRLGLKVPDDMAIAGFHGHDIGQVMEPRLASVLTPRERMGSIGAERLLARIRGESVTPKMLDLGFTLSPGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BD0</accession>
    <name>Q32BD0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable sigma-54 modulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhbH</name>
        <name evidence="2" type="ordered locus">SDY_3384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001176599.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404866.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BD0"/>
    <dbReference type="SMR" id="Q32BD0"/>
    <dbReference type="STRING" id="300267.SDY_3384"/>
    <dbReference type="EnsemblBacteria" id="ABB63375">
        <property type="protein sequence ID" value="ABB63375"/>
        <property type="gene ID" value="SDY_3384"/>
    </dbReference>
    <dbReference type="GeneID" id="66672895"/>
    <dbReference type="KEGG" id="sdy:SDY_3384"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4038"/>
    <dbReference type="HOGENOM" id="CLU_071472_3_1_6"/>
    <dbReference type="OMA" id="NLTGHHI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="95" mass="10750" checksum="5B8F737E6E3A91AE" modified="2005-12-06" version="1">MQLNITGNNVEITEALREFVTAKFAKLEQYFDRINQVYVVLKVEKVTHTSDATLHVNGGEIHASAEGQDMYAAIDGLIDKLARQLTKHKDKLKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BF1</accession>
    <name>Q32BF1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase, fraction B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dacB</name>
        <name evidence="3" type="ordered locus">SDY_3363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001212663.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404845.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BF1"/>
    <dbReference type="STRING" id="300267.SDY_3363"/>
    <dbReference type="MEROPS" id="S13.001"/>
    <dbReference type="EnsemblBacteria" id="ABB63354">
        <property type="protein sequence ID" value="ABB63354"/>
        <property type="gene ID" value="SDY_3363"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3363"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4017"/>
    <dbReference type="HOGENOM" id="CLU_017692_1_1_6"/>
    <dbReference type="OMA" id="DGTMRKR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221005" evidence="2">
        <location>
            <begin position="21"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="477" mass="51750" checksum="4B8B75929B275B50" modified="2005-12-06" version="1">MRFSRFIIGLTSCIAFSVQAANVDEYVTQLPAGANLALMVQKVGASAPAIDYHSQQMALPASTQKVITALAALIQLGPDFRFTTTLETKGNVENGVLKGDLVARFGADPTLKRQDIRNMVATLKKSGVNQIDGNVLIDTSIFASHDKAPGWPWNDMTQCFSAPPAAAIVDRNCLSVSLYSAPKPGDMAFIRVASYYPVTMFSQVRTLPRGSAEAQYCELDVVPGDLNRFTLTGCLPQRSEPLPLAFAVQDGASYAGAILKDELKQAGITWSGTLLRQTQVNEPGTVVASKQSAPLHDLLKIMLKKSDNMIADTVFRMIGHARFNVPGTWRAGSDAVRQILRQQAGVDIGNTIIADGSGLSRHNLIAPATMMQVLQYIAQHDNELNFISMLPLAGYDGSLQYRAGLHQAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQYLSGYAVEPADQRNRRIPLVRFESRLYKDIYQNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BI4</accession>
    <name>YRAN_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0102 protein YraN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yraN</name>
        <name type="ordered locus">SDY_3327</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000246855.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404812.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BI4"/>
    <dbReference type="SMR" id="Q32BI4"/>
    <dbReference type="STRING" id="300267.SDY_3327"/>
    <dbReference type="EnsemblBacteria" id="ABB63321">
        <property type="protein sequence ID" value="ABB63321"/>
        <property type="gene ID" value="SDY_3327"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3327"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3980"/>
    <dbReference type="HOGENOM" id="CLU_115353_1_0_6"/>
    <dbReference type="OMA" id="RNWRCGR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000009266" description="UPF0102 protein YraN">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="131" mass="14798" checksum="D616B5F57E7AC22E" modified="2005-12-06" version="1">MATVPTRSGSPRQLTTKQTGDAWEVQARRWLEGKGLRFVAANVNERGGEIDLIMREGRTTVFVEVRYRRSALYGGAAASVTRSKQHKLLQTARLWLARHNGSFDTVDCRFDVVAFTGNEVEWIKDAFNDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BK3</accession>
    <name>Q32BK3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Formate acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">tdcE</name>
        <name evidence="12" type="ordered locus">SDY_3306</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000861751.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404793.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BK3"/>
    <dbReference type="STRING" id="300267.SDY_3306"/>
    <dbReference type="EnsemblBacteria" id="ABB63302">
        <property type="protein sequence ID" value="ABB63302"/>
        <property type="gene ID" value="SDY_3306"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3306"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3952"/>
    <dbReference type="HOGENOM" id="CLU_023898_0_0_6"/>
    <dbReference type="OMA" id="MNTIHYM"/>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="5 7 8" id="KW-0556">Organic radical</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="11">
        <location>
            <begin position="7"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="10">
        <location>
            <begin position="636"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="7">
        <location>
            <position position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="764" mass="85944" checksum="FF95C64B8EB875CF" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BK5</accession>
    <name>Q32BK5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_3303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404791.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BK5"/>
    <dbReference type="STRING" id="300267.SDY_3303"/>
    <dbReference type="EnsemblBacteria" id="ABB63300">
        <property type="protein sequence ID" value="ABB63300"/>
        <property type="gene ID" value="SDY_3303"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3303"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3948"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="OMA" id="WATARIM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="10009" checksum="EDD094197AD575CE" modified="2005-12-06" version="1">MASVSISCPSCSATDGVVRNGKSTARHQHYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCWATARIMGVSLNTILRHLKNSGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BR5</accession>
    <name>Q32BR5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BR5"/>
    <dbReference type="EnsemblBacteria" id="ABB63240">
        <property type="protein sequence ID" value="ABB63240"/>
        <property type="gene ID" value="SDY_3232"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3232"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="70" mass="7783" checksum="38042FC3D606DD5B" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITKMCIKSTGEHVTADKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BV5</accession>
    <name>Q32BV5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">recJ</name>
        <name evidence="9" type="ordered locus">SDY_3190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000813170.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404691.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BV5"/>
    <dbReference type="STRING" id="300267.SDY_3190"/>
    <dbReference type="EnsemblBacteria" id="ABB63200">
        <property type="protein sequence ID" value="ABB63200"/>
        <property type="gene ID" value="SDY_3190"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3190"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3812"/>
    <dbReference type="HOGENOM" id="CLU_009736_5_1_6"/>
    <dbReference type="OMA" id="FIICDHH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="73"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="322"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="469"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="577" mass="63390" checksum="CCB82BEFA8656ADF" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C61</accession>
    <name>Q32C61_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable cytochrome Ni/Fe component of hydrogenase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hybB</name>
        <name evidence="8" type="ordered locus">SDY_3078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000017703.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404585.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C61"/>
    <dbReference type="SMR" id="Q32C61"/>
    <dbReference type="STRING" id="300267.SDY_3078"/>
    <dbReference type="EnsemblBacteria" id="ABB63094">
        <property type="protein sequence ID" value="ABB63094"/>
        <property type="gene ID" value="SDY_3078"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3078"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3685"/>
    <dbReference type="HOGENOM" id="CLU_049007_0_0_6"/>
    <dbReference type="OMA" id="AIEVCAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="392" mass="43602" checksum="8A25CDCB3EDB67FA" modified="2005-12-06" version="1">MSHDPQPLGGKIISKPVMIFGPLIVICMLLIVKRLVFGLGSVSDLNGGFPWGVWIAFDLLIGTGFACGGWALAWAVYVFNRGQYHPLVRPALLASLFGYSLGGLSITIDVGRYWNLPYFYIPGHFNVNSVLFETAVCMTIYIGVMALEFAPALFERLGWKVSLQRLNKVMFFIIALGALLPTMHQSSMGSLMISAGYKVHPLWQSYEMLPLFSLLTAFIMGFSIVIFEGSLVQAGLRGNGPDEKSLFVKLTNTISVLLAIFIVLRFGELIYRDKLSLAFAGDFYSVMFWIEVLLMLFPLVVLRVAKLRNDSRMLFLSALSALLGCATWRLTYSLVAFNPGGGYAYFPTWEELLISIGFVAIEICAYIVLIRLLPILPPLKQNDHNRHEASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C95</accession>
    <name>Q32C95_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prepilin peptidase dependent protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppdA</name>
        <name evidence="3" type="ordered locus">SDY_3043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000857051.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404551.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C95"/>
    <dbReference type="SMR" id="Q32C95"/>
    <dbReference type="STRING" id="300267.SDY_3043"/>
    <dbReference type="EnsemblBacteria" id="ABB63060">
        <property type="protein sequence ID" value="ABB63060"/>
        <property type="gene ID" value="SDY_3043"/>
    </dbReference>
    <dbReference type="GeneID" id="66673307"/>
    <dbReference type="KEGG" id="sdy:SDY_3043"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3648"/>
    <dbReference type="HOGENOM" id="CLU_118590_1_0_6"/>
    <dbReference type="OMA" id="LRNTAWP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="156" mass="17865" checksum="B087405B39F9A432" modified="2005-12-06" version="1">MKTQRGYTLIETLVAMLILVMLSASGLYGWQYWQQSQRLWQTASQARDYLLYLREDANWHNRDHSISVIREGTLWCLVSSAAGANTCHGSSPLVFVPRWPEVEMSDLTPSLAFFGLRNTAWAGHIRFKNSTGEWWLVVSPWGRLRLCQQGETEGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CD4</accession>
    <name>Q32CD4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mazG</name>
        <name evidence="2" type="ordered locus">SDY_2998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001071643.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404512.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CD4"/>
    <dbReference type="STRING" id="300267.SDY_2998"/>
    <dbReference type="EnsemblBacteria" id="ABB63021">
        <property type="protein sequence ID" value="ABB63021"/>
        <property type="gene ID" value="SDY_2998"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2998"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3597"/>
    <dbReference type="HOGENOM" id="CLU_038356_0_1_6"/>
    <dbReference type="OMA" id="HPHIYGD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="169"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="263" mass="30426" checksum="2F50C6874378CA05" modified="2005-12-06" version="1">MNQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQEEGRFDFNDICAAISDKLERRHPHVFADSSAENSSEVLARWEQIKTEERAQKAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLGPVVDKVYEEIDEVMYEARQAVIDQAKLEEEMGDLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMTGVDLETMEEVWQQVKRQEIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CK3</accession>
    <name>Q32CK3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleiotrophic effects on 3 hydrogenase isozymes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hypC</name>
        <name evidence="3" type="ordered locus">SDY_2925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000334881.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404443.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CK3"/>
    <dbReference type="SMR" id="Q32CK3"/>
    <dbReference type="STRING" id="300267.SDY_2925"/>
    <dbReference type="EnsemblBacteria" id="ABB62952">
        <property type="protein sequence ID" value="ABB62952"/>
        <property type="gene ID" value="SDY_2925"/>
    </dbReference>
    <dbReference type="GeneID" id="67413974"/>
    <dbReference type="KEGG" id="sdy:SDY_2925"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3513"/>
    <dbReference type="HOGENOM" id="CLU_159381_1_1_6"/>
    <dbReference type="OMA" id="MCLAIPC"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="9732" checksum="FBE252F1875C7879" modified="2005-12-06" version="1">MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPDVGALLYGEEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CQ1</accession>
    <name>NRDI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein NrdI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nrdI</name>
        <name type="ordered locus">SDY_2867</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in ribonucleotide reductase function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NrdI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000080962.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404395.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CQ1"/>
    <dbReference type="SMR" id="Q32CQ1"/>
    <dbReference type="STRING" id="300267.SDY_2867"/>
    <dbReference type="EnsemblBacteria" id="ABB62904">
        <property type="protein sequence ID" value="ABB62904"/>
        <property type="gene ID" value="SDY_2867"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2867"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3446"/>
    <dbReference type="HOGENOM" id="CLU_114845_0_0_6"/>
    <dbReference type="OMA" id="NTHRFVG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00128">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020852">
        <property type="entry name" value="RNR_Ib_NrdI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004465">
        <property type="entry name" value="RNR_NrdI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37297">
        <property type="entry name" value="PTHR37297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07972">
        <property type="entry name" value="Flavodoxin_NdrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005087">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00333">
        <property type="entry name" value="nrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000016522" description="Protein NrdI">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00128"/>
        </source>
    </evidence>
    <sequence length="136" mass="15311" checksum="809652238E5A4BC3" modified="2005-12-06" version="1">MSQLVYFSSSSENTQRFIERLGLPAVRIPLNERKQIQVDEPYILIVPSYGGGGTAGAVPRQVIRFLNDEHNRALLRGVIASGNRNFGEAYGRAGDVIARKCGVPWLYRFELMGTQSDIENVRKGVTEFWQRQPQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CQ9</accession>
    <name>Q32CQ9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">stpA</name>
        <name evidence="10" type="ordered locus">SDY_2859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the histone-like protein H-NS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000115383.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404387.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CQ9"/>
    <dbReference type="SMR" id="Q32CQ9"/>
    <dbReference type="STRING" id="300267.SDY_2859"/>
    <dbReference type="EnsemblBacteria" id="ABB62896">
        <property type="protein sequence ID" value="ABB62896"/>
        <property type="gene ID" value="SDY_2859"/>
    </dbReference>
    <dbReference type="GeneID" id="66673461"/>
    <dbReference type="KEGG" id="sdy:SDY_2859"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3434"/>
    <dbReference type="HOGENOM" id="CLU_117503_0_0_6"/>
    <dbReference type="OMA" id="NTWLELM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027444">
        <property type="entry name" value="H-NS_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037150">
        <property type="entry name" value="H-NS_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001801">
        <property type="entry name" value="Histone_HNS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027454">
        <property type="entry name" value="Histone_HNS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00816">
        <property type="entry name" value="Histone_HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002096">
        <property type="entry name" value="HnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00528">
        <property type="entry name" value="HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNS" evidence="9">
        <location>
            <begin position="87"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="6">
        <location>
            <begin position="112"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="134" mass="15348" checksum="5870BD95F144CE6A" modified="2005-12-06" version="1">MSVMLQSLNNIRTLRAMAREFSIDVLEEMLEKFRVVTKERREEEEQQQRELAERQEKISTWLELMKADGINPEELLGNSSAAAPRAGKKRQPRPAKYKFTDVNGETKTWTGQGRTPKPIAQALAEGKSLDDFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CR2</accession>
    <name>Q32CR2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_2856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000508177.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404384.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CR2"/>
    <dbReference type="STRING" id="300267.SDY_2856"/>
    <dbReference type="EnsemblBacteria" id="ABB62893">
        <property type="protein sequence ID" value="ABB62893"/>
        <property type="gene ID" value="SDY_2856"/>
    </dbReference>
    <dbReference type="GeneID" id="67414042"/>
    <dbReference type="KEGG" id="sdy:SDY_2856"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3431"/>
    <dbReference type="HOGENOM" id="CLU_107649_7_1_6"/>
    <dbReference type="OMA" id="VHAIWVI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="PTHR21659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="52" mass="5865" checksum="35AF407B378B8225" modified="2005-12-06" version="1">MGFWRIVITIILPPLGVLLGKGFGWAFIINILLTLLGYIPGLIHAFWVQTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CT0</accession>
    <name>Q32CT0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yfiH</name>
        <name evidence="10" type="ordered locus">SDY_2836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000040124.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404366.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CT0"/>
    <dbReference type="STRING" id="300267.SDY_2836"/>
    <dbReference type="EnsemblBacteria" id="ABB62875">
        <property type="protein sequence ID" value="ABB62875"/>
        <property type="gene ID" value="SDY_2836"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2836"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3409"/>
    <dbReference type="HOGENOM" id="CLU_065784_1_1_6"/>
    <dbReference type="OMA" id="CFADCVP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="243" mass="26342" checksum="D04600C00DA5172E" modified="2005-12-06" version="1">MSKLIVPQWPLPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTLGTVCAVMTADCLPVLFCNRAGTEVAAAHAGWRGLCAGVLEETVSCFADNPENILVWLGPAIGPRAFEVGAEVREAFMAADAKASTAFIQHGDKYLADIYLLARQRLASVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D30</accession>
    <name>Q32D30_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative enzyme</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404266.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D30"/>
    <dbReference type="STRING" id="300267.SDY_2730"/>
    <dbReference type="ESTHER" id="shifl-S2753">
        <property type="family name" value="ABHD13-BEM46"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.A36"/>
    <dbReference type="EnsemblBacteria" id="ABB62775">
        <property type="protein sequence ID" value="ABB62775"/>
        <property type="gene ID" value="SDY_2730"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2730"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3292"/>
    <dbReference type="HOGENOM" id="CLU_029375_2_1_6"/>
    <dbReference type="OMA" id="PNGGHND"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="86"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="293" mass="32476" checksum="64956EA35B13841A" modified="2005-12-06" version="1">MIKKSQGKVMALPVNKRVPKILFILFVVAFCVYLVPRVAINFFYYPDDKIYGPDPWSAESVEFTAKDGTRLQGWFIPSSTGPADNAIATIIHAHGNAGNMSAHWPLVSWLPERNFNVFMFDYRGFGKSKGTPSQAGLLDDTQSAINMVRHRSDVNPQRLVLFGQSIGGANILAVIGQGDREGIRAVILDSTFASYATIANQMIPGSGYLLDESYSGENYIASVSPIPLLLIHGKADHVIPWQHSEKLYSLAKEPKRLILIPDGEHIDAFSDRHGDVYREQMVDFILSALNPQN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D38</accession>
    <name>HSCA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein HscA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hsc66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hscA</name>
        <name type="ordered locus">SDY_2722</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001196613.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404258.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D38"/>
    <dbReference type="SMR" id="Q32D38"/>
    <dbReference type="STRING" id="300267.SDY_2722"/>
    <dbReference type="EnsemblBacteria" id="ABB62767">
        <property type="protein sequence ID" value="ABB62767"/>
        <property type="gene ID" value="SDY_2722"/>
    </dbReference>
    <dbReference type="GeneID" id="67416910"/>
    <dbReference type="KEGG" id="sdy:SDY_2722"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3283"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_6"/>
    <dbReference type="OMA" id="PDPHQRR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10236">
        <property type="entry name" value="HscA_like_NBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00679">
        <property type="entry name" value="HscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042039">
        <property type="entry name" value="HscA_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010236">
        <property type="entry name" value="ISC_FeS_clus_asmbl_HscA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01991">
        <property type="entry name" value="HscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000044896" description="Chaperone protein HscA">
        <location>
            <begin position="1"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00679"/>
        </source>
    </evidence>
    <sequence length="616" mass="65652" checksum="9C80E6EF1BFDAB48" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D52</accession>
    <name>Q32D52_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404244.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D52"/>
    <dbReference type="STRING" id="300267.SDY_2706"/>
    <dbReference type="EnsemblBacteria" id="ABB62753">
        <property type="protein sequence ID" value="ABB62753"/>
        <property type="gene ID" value="SDY_2706"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2706"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3264"/>
    <dbReference type="HOGENOM" id="CLU_184340_0_0_6"/>
    <dbReference type="OMA" id="SRVRFEF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010807">
        <property type="entry name" value="DUF1407"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029037">
        <property type="entry name" value="YfgJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07191">
        <property type="entry name" value="zinc-ribbons_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="78" mass="8536" checksum="84FF09492CF2E655" modified="2005-12-06" version="1">MATGGIHMELHCPQCQHVLDQDNGHAHCPSCGEVIEMKALCPDCHQPLQVLKACGAVDYFCQHGHGLISKKRVEFVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D86</accession>
    <name>Q32D86_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine cleavage system transcriptional repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvR</name>
        <name evidence="3" type="ordered locus">SDY_2668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D86"/>
    <dbReference type="STRING" id="300267.SDY_2668"/>
    <dbReference type="EnsemblBacteria" id="ABB62719">
        <property type="protein sequence ID" value="ABB62719"/>
        <property type="gene ID" value="SDY_2668"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2668"/>
    <dbReference type="HOGENOM" id="CLU_095322_0_0_6"/>
    <dbReference type="OMA" id="TGGTMLN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016867">
        <property type="entry name" value="GcvR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028103">
        <property type="entry name" value="GcvR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="119"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="212" mass="23262" checksum="6E3177D91620C42B" modified="2005-12-06" version="1">MLYACFFYAFLKNNSPLKGITSLTLSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGEEFTFIMLLSGSWNAITLIESTLPLKGAELDLLIVMKRTTARPRPPMPASVWVQVDVADSPHLIERFTALFDAHHMNIAELVSRTQPAENERAAQLHIQITAHSPASADAANIEQAFKALCTELNAQGSINVVNYSQHDEQDGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DD4</accession>
    <name>Q32DD4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfeK</name>
        <name evidence="2" type="ordered locus">SDY_2616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000719946.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404162.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DD4"/>
    <dbReference type="STRING" id="300267.SDY_2616"/>
    <dbReference type="EnsemblBacteria" id="ABB62671">
        <property type="protein sequence ID" value="ABB62671"/>
        <property type="gene ID" value="SDY_2616"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2616"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3153"/>
    <dbReference type="HOGENOM" id="CLU_128254_0_0_6"/>
    <dbReference type="OMA" id="CASRSEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035242">
        <property type="entry name" value="DUF5329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17263">
        <property type="entry name" value="DUF5329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221034" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="122" mass="13435" checksum="16F4C360FA27175A" modified="2005-12-06" version="1">MKKIICLVITLLMTLPAYAKLTAHEEARINAMLEGLAQKKDLIFVRNGDEHTCDEAVSHLRLKLGNTRNRINTAEQFIDKVASSSSITGKPDIVKIPGKSDENAQPFLHALIAQTDKTVPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DP3</accession>
    <name>Q32DP3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ackA</name>
        <name evidence="8" type="ordered locus">SDY_2492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000095714.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404053.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DP3"/>
    <dbReference type="STRING" id="300267.SDY_2492"/>
    <dbReference type="EnsemblBacteria" id="ABB62562">
        <property type="protein sequence ID" value="ABB62562"/>
        <property type="gene ID" value="SDY_2492"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2492"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3004"/>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_6"/>
    <dbReference type="OMA" id="KIITCHI"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="285"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="333"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="400" mass="43278" checksum="E4A275555ABB56CE" modified="2005-12-06" version="1">MSSKLVLVLNCGSSSLKFAIIDAVNGEEYLSGLAECFHLPEARIKWKMDGNKQEAALGAGAAHSEALNFIVNTILAQKPELSAQLTAIGHRIVHGGEKYTSSVVIDESVIQGIKDAASFAPLHNPAHLTGIEEALKSFPQLKDKNVAVFDTAFHQTMPEESYLYALPYNLYKEHGIRRYGAHGTSHFYVTQEAAKMLNKPVEELNIITCHLGNGGSVSAIRNGKCVDTSMGLTPLEGLVMGTRSGDIDPAIIFHLHDTLGMSVDAINKLLTKESGLLGLTEVTSDCRYVEDNYATKEDAKRAMDVYCHRLAKYIGAYTALMDGRLDAVVFTGGIGENAAMVRELSLGKLGVLGFEVDHERNLAARFGKSGFINKEGTRPAVVIPTNEELVIAQDASRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DR8</accession>
    <name>Q32DR8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_1182</name>
        <name evidence="4" type="ordered locus">SDY_2467</name>
        <name evidence="5" type="ordered locus">SDY_3827</name>
        <name evidence="6" type="ordered locus">SDY_3853</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000748.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402829.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404028.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405263.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405286.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61338">
        <property type="protein sequence ID" value="ABB61338"/>
        <property type="gene ID" value="SDY_1182"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62537">
        <property type="protein sequence ID" value="ABB62537"/>
        <property type="gene ID" value="SDY_2467"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63772">
        <property type="protein sequence ID" value="ABB63772"/>
        <property type="gene ID" value="SDY_3827"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63795">
        <property type="protein sequence ID" value="ABB63795"/>
        <property type="gene ID" value="SDY_3853"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1182"/>
    <dbReference type="KEGG" id="sdy:SDY_2467"/>
    <dbReference type="KEGG" id="sdy:SDY_3827"/>
    <dbReference type="KEGG" id="sdy:SDY_3853"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1396"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14964" checksum="F8C7EA5DEE7B4BB8" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRFRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DS4</accession>
    <name>MEND_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</fullName>
            <shortName evidence="1">SEPHCHC synthase</shortName>
            <ecNumber evidence="1">2.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthesis protein MenD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">menD</name>
        <name type="ordered locus">SDY_2460</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="2.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="1">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family. MenD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005017964.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404022.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DS4"/>
    <dbReference type="SMR" id="Q32DS4"/>
    <dbReference type="STRING" id="300267.SDY_2460"/>
    <dbReference type="EnsemblBacteria" id="ABB62531">
        <property type="protein sequence ID" value="ABB62531"/>
        <property type="gene ID" value="SDY_2460"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2460"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2967"/>
    <dbReference type="HOGENOM" id="CLU_006051_3_0_6"/>
    <dbReference type="OMA" id="FCNRGTS"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01659">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032264">
        <property type="entry name" value="MenD_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16582">
        <property type="entry name" value="TPP_enzyme_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004983">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000341844" description="2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase">
        <location>
            <begin position="1"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01659"/>
        </source>
    </evidence>
    <sequence length="556" mass="61226" checksum="C9C81F8ED7453CCA" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DU3</accession>
    <name>Q32DU3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yfaD</name>
        <name evidence="3" type="ordered locus">SDY_2439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000140558.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404003.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DU3"/>
    <dbReference type="EnsemblBacteria" id="ABB62512">
        <property type="protein sequence ID" value="ABB62512"/>
        <property type="gene ID" value="SDY_2439"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2439"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2939"/>
    <dbReference type="HOGENOM" id="CLU_059548_1_0_6"/>
    <dbReference type="OMA" id="CRDMLEW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="2">
        <location>
            <begin position="8"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="308" mass="35720" checksum="71D5B76FD3DDEE81" modified="2005-12-06" version="1">MTESTTSSPHDAVFKTFMFTPETARDFLEIHLPEPLRKLCNLQTLRLEPTSFIEKSLRAYYSDVLWSVETSDGDGYIYCVIEHQSSAEKNMAFRLMRYATAAMQHHLDKGYDRVPLVVPLLFYHGETSPYPYSLNWLDEFDDPQLARQLYTEAFPLVDITIVPDDEIMQHRRIALLELIQKHIRNRDLIGMVDRITPLLVRGFTNDSQLQTLFNYLLQCGDTSRFTRFIQEIAERSPLQKERLMTIAERLRQEGHQIGWQEGKLEGLQEGMHEQAIKIALRMLEQGFDRDLVLAATQLSEADLAANNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DY9</accession>
    <name>Q32DY9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyruvate dehydrogenase [ubiquinone]</fullName>
            <ecNumber evidence="2">1.2.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Pyruvate oxidase</fullName>
            <shortName evidence="2">POX</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pyruvate:ubiquinone-8 oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">poxB</name>
        <name evidence="7" type="ordered locus">SDY_2392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A peripheral cell membrane enzyme that catalyzes the oxidative decarboxylation of pyruvate to form acetate and CO(2). It channels electrons from the cytoplasm to the respiratory chain at the cell membrane via ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2</text>
            <dbReference type="Rhea" id="RHEA:27405"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="1.2.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="2">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The C-terminus inhibits activity; it has to move for the enzyme to be active. Activated by lipid-binding, which occurs via the C-terminus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">Has 4 domains; the Pyr domain which binds the pyrimidine moiety of the thiamine pyrophosphate cofactor, the FAD-binding domain, the PP-binding domain which binds the pyrophosphate portion of thiamine pyrophosphate and the C-terminal membrane binding region. The C-terminus is held closely against the rest of the protein and covers the active site; during activation it unfolds from the rest of the protein and forms an amphipathic helix upon membrane binding, exposing the active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.5.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000815336.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403957.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DY9"/>
    <dbReference type="STRING" id="300267.SDY_2392"/>
    <dbReference type="EnsemblBacteria" id="ABB62466">
        <property type="protein sequence ID" value="ABB62466"/>
        <property type="gene ID" value="SDY_2392"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2392"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2885"/>
    <dbReference type="HOGENOM" id="CLU_013748_3_0_6"/>
    <dbReference type="OMA" id="YEATHEC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052737">
        <property type="term" value="F:pyruvate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042867">
        <property type="term" value="P:pyruvate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00850">
        <property type="entry name" value="POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044261">
        <property type="entry name" value="PoxB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="192"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="379"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="FAD-binding domain" evidence="2">
        <location>
            <begin position="183"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="PP-binding domain" evidence="2">
        <location>
            <begin position="335"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="2">
        <location>
            <begin position="406"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="2">
        <location>
            <begin position="433"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="2">
        <location>
            <begin position="460"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Membrane-binding domain" evidence="2">
        <location>
            <begin position="531"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="274"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Moves into active site upon enzyme activation, plays a role in electron transfer" evidence="2">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="572" mass="62010" checksum="B5FE809239B99272" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DZ0</accession>
    <name>Q32DZ0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_2391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000178644.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403956.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DZ0"/>
    <dbReference type="STRING" id="300267.SDY_2391"/>
    <dbReference type="EnsemblBacteria" id="ABB62465">
        <property type="protein sequence ID" value="ABB62465"/>
        <property type="gene ID" value="SDY_2391"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2391"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2884"/>
    <dbReference type="HOGENOM" id="CLU_003827_14_3_6"/>
    <dbReference type="OMA" id="MQVHHIH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="237"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="322" mass="35797" checksum="5D21FFCFD535833F" modified="2005-12-06" version="1">MTMPTNQCPWRMQVHHIKQETPDVWTISLICHDYYPYRAGQYALVSVRNSAETLRAYTISSTPGVSEYITLTVRRIDDGVGSQWLTRDVKRGDYLWLSDAMGEFTCDDKAEDKFLLLAAGCGVTPIMSMRRWLAKNRPQADVRVIYNVRTPQDVIFADEWRNYPVTLVAENNVTEGFIAGRLTRELLASVPDLASRTVMTCGPAPYMDWVEQEVKALGVTRFFKEKFFTPVAEAATSGLKFTKLQPAREFYAPVGTTLLEALESNNVPVVAACRAGVCGCCKTKVVSGEYTVSSTMTLTDAEIAEGYVLACSCHPQGDLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E92</accession>
    <name>Q32E92_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E92"/>
    <dbReference type="EnsemblBacteria" id="ABB62363">
        <property type="protein sequence ID" value="ABB62363"/>
        <property type="gene ID" value="SDY_2286"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2286"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7707" checksum="BD2A7323F0073016" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARITHQIQLIRGITRIFIEPPDYYWQI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E99</accession>
    <name>RCNR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional repressor RcnR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rcnR</name>
        <name type="ordered locus">SDY_2279</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FrmR/RcnR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000019944.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403847.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E99"/>
    <dbReference type="SMR" id="Q32E99"/>
    <dbReference type="STRING" id="300267.SDY_2279"/>
    <dbReference type="EnsemblBacteria" id="ABB62356">
        <property type="protein sequence ID" value="ABB62356"/>
        <property type="gene ID" value="SDY_2279"/>
    </dbReference>
    <dbReference type="GeneID" id="67417885"/>
    <dbReference type="KEGG" id="sdy:SDY_2279"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2752"/>
    <dbReference type="HOGENOM" id="CLU_130332_3_0_6"/>
    <dbReference type="OMA" id="EHECAEI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000332704" description="Transcriptional repressor RcnR">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="90" mass="10134" checksum="BEF3E5AE971AA2F6" modified="2005-12-06" version="1">MSHTIRDKQKLKARASKIQGQVVALKKMLDEPHECAAVLQQIAAIRGAVNGLMREVIKGHLTEHIVHQGDELKREEDLDVVLKVLDSYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EE7</accession>
    <name>Q32EE7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzyme of sugar metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000754700.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403799.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EE7"/>
    <dbReference type="STRING" id="300267.SDY_2223"/>
    <dbReference type="EnsemblBacteria" id="ABB62308">
        <property type="protein sequence ID" value="ABB62308"/>
        <property type="gene ID" value="SDY_2223"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2223"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2687"/>
    <dbReference type="HOGENOM" id="CLU_007383_11_1_6"/>
    <dbReference type="OMA" id="MVHRDDA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="274" mass="29754" checksum="BE5DB7B0FA4A0DC8" modified="2005-12-06" version="1">MKKVAIVGLGWLGMPLAMLLSARGWQVTGSKTTQDGVEAARMSGIDSYLLRMEPELVCDSDDLDALMDADALVITLPARRSGPGDEFYLQAVQELVDSALAHRIPRIIFTSSTSVYGDAQGTVKETTPRNPVTNSGRILEELEDWLHNLPGTSVDILRLAGLVGPGRHPGRFFAGKTAPDGEHGVNLVHLEDVIGAITLLLQAPKGGHFYNICAPAHPARNVFYPQMARLLGLEPPQFRNSLDSGKGKIIDGSRICNELGFEYQYPDPLVMPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EF5</accession>
    <name>Q32EF5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine biosynthesis bifunctional protein HisIE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <shortName evidence="13">PRA-CH</shortName>
                <ecNumber evidence="13">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">Phosphoribosyl-ATP pyrophosphatase</fullName>
                <shortName evidence="13">PRA-PH</shortName>
                <ecNumber evidence="13">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">hisI</name>
        <name evidence="13" type="synonym">hisIE</name>
        <name evidence="15" type="ordered locus">SDY_2215</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the C-terminal section; belongs to the PRA-PH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">In the N-terminal section; belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="13"/>
    <dbReference type="EC" id="3.6.1.31" evidence="13"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000954883.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403791.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EF5"/>
    <dbReference type="STRING" id="300267.SDY_2215"/>
    <dbReference type="EnsemblBacteria" id="ABB62300">
        <property type="protein sequence ID" value="ABB62300"/>
        <property type="gene ID" value="SDY_2215"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2215"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2679"/>
    <dbReference type="HOGENOM" id="CLU_048577_3_1_6"/>
    <dbReference type="OMA" id="ERSCFHQ"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01019">
        <property type="entry name" value="HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023019">
        <property type="entry name" value="His_synth_HisIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRA-CH" evidence="14">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-AMP cyclohydrolase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-ATP pyrophosphohydrolase" evidence="13">
        <location>
            <begin position="115"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB62300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="203" mass="22885" checksum="76EA1019684910C3" modified="2005-12-06" version="1">MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTIESGKVTFFSRTKQRLWTKGETSGNFLNVVNITPDCDNDTLLLLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EG2</accession>
    <name>Q32EG2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative O-antigen transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rfbX</name>
        <name evidence="6" type="ordered locus">SDY_2208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000739384.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403784.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EG2"/>
    <dbReference type="SMR" id="Q32EG2"/>
    <dbReference type="STRING" id="300267.SDY_2208"/>
    <dbReference type="EnsemblBacteria" id="ABB62293">
        <property type="protein sequence ID" value="ABB62293"/>
        <property type="gene ID" value="SDY_2208"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2208"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2671"/>
    <dbReference type="HOGENOM" id="CLU_022017_0_2_6"/>
    <dbReference type="OMA" id="RTQYLIP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="396" mass="44309" checksum="4C1E506865CDF4BE" modified="2005-12-06" version="1">MKKNILLLFLVHGANYLFPFIVLPYQTRILSIETFADVAKIQAAVMLLSLIVNYGYNLSSTRAIARAVSQAEINKIYSETLIVKLLLATICLALGCVHLMYVKEYSLIYPFIISSIYLYGSALFATWLFQGLEKMKAVVIATTIAKLTGVILTFILVKSPNDIVAALFTQNIGMFISGIISIYLVRKNKYATVICFRLKNIIVSLKEAWPFFLSLAATSVYTYFNVILLSFYAGDYVVANFNAADKLRMAAQGLLIPIGQAVFPRLSKLEGYEYSSKLKIYAIRYAIFGVCISAGLVFLGPMLTTIYLGKEYSLSGEYLQSMFLLPATISISTILSQWMLIPQGKEKILSRIYILGAIVHLLYAFPLVYYYGAWGMVISILFTEVLIVLFMLKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EJ9</accession>
    <name>Q32EJ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403747.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EJ9"/>
    <dbReference type="STRING" id="300267.SDY_2170"/>
    <dbReference type="EnsemblBacteria" id="ABB62256">
        <property type="protein sequence ID" value="ABB62256"/>
        <property type="gene ID" value="SDY_2170"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2170"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2622"/>
    <dbReference type="HOGENOM" id="CLU_020792_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="363" mass="40183" checksum="407E1FD1C27C1572" modified="2005-12-06" version="1">MACGESSVMNSLRPELLELTPQALTALSNAGFVKRSLKELENGNVPEISHENGALIATFSDGVRTQLANGQALKEAQCTCGASGMCRHRVMLVLSYQRLCATAQPTGKEEEWDPAIWLEELATLPDATRKRAQALVAKGITIELFCTPGEIPSARLPMSDVRFYSRSSIRFARCDCIEGTLCEHVVLAVQAFVQAKAQQAELTHLIWQMRSEHVTSSDDPFASEEGKTCRQYVQQLSQALWLSGISQPLIHYEAAFNRALQAAEACNWRWVSESLRQLRASVDAFHARASHYHAGECLRQLAALNSRLNCAQEMARRDSVGEVSPVPWRTVVGSGIAGEAKLDHLRLVDWPPESPDNQYHLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EM0</accession>
    <name>Q32EM0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yohI</name>
        <name evidence="4" type="ordered locus">SDY_2147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EM0"/>
    <dbReference type="STRING" id="300267.SDY_2147"/>
    <dbReference type="EnsemblBacteria" id="ABB62235">
        <property type="protein sequence ID" value="ABB62235"/>
        <property type="gene ID" value="SDY_2147"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2147"/>
    <dbReference type="HOGENOM" id="CLU_013299_0_4_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032886">
        <property type="entry name" value="DusC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042270">
        <property type="entry name" value="DusC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF26">
        <property type="entry name" value="PTHR11082:SF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Dus" evidence="3">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="191" mass="21753" checksum="877E5955EF023AD7" modified="2005-12-06" version="1">MREAVPAHLPVSVKVRLGWDSGEKKFEIADAVQQAGATELVVHGRTKEQGYRAEHIDWQAIGEIRQQLNIPVIANGEIWDWQSAQQCMAISGCDAVMIGRGALNIPNLSRVVKYNEPRMPWPEVVALLQKYTRLEKQGDTGLYHVARIKQWLSYLRKEYDEATELFQHVRVLNNSPDIARAIQAIDIDKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EP2</accession>
    <name>Q32EP2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001201594.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403704.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EP2"/>
    <dbReference type="STRING" id="300267.SDY_2123"/>
    <dbReference type="EnsemblBacteria" id="ABB62213">
        <property type="protein sequence ID" value="ABB62213"/>
        <property type="gene ID" value="SDY_2123"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2123"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2557"/>
    <dbReference type="HOGENOM" id="CLU_006332_14_0_6"/>
    <dbReference type="OMA" id="DDTMLIV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="493" mass="56990" checksum="FECE0E84D72367E1" modified="2005-12-06" version="1">MRAIILLFDSLNKRYLPPYGDALTKAPNFQRLAAHAATFENSYVGSMPCMPARRELHTGRCNFLHREWGPLEPFDDSMPELLKKAGIYTHLISDHLHYWEDGGGNYHNRYSSWEIVRGQEGDHWHASVAQPPIPEVLRGPQKQTGGGVSGLWRHDWANREYIQQEADFPQTKVFDAGSAFIHKNHAEDNWLLQVETFDPHEPFHTTEEYLSLYEDNWDGPHYDWLRGRVQESDEAVEHIRCRYRSLVSMCDRNLGRILDLMDEHDLWRDTMLIVGTDHGFLLGEHGWWAKNQMPYYNEVANNPLFIWDPRSGVKGERRQALVQMIDWAPTLYDFFQQPVPPDVQGQPLAKTVSHDEPVRSSAMFGVFSGHANVTDGRYVYMRAALPGREDDIANYTLMSCKMNSRYPVDEMRALSLAPPFRFTKGLQVLRIPAQEKYKGLNQFGHLLFDLQNDPQQLHPIHDDVIESRMIALLIQLMKDNDAPPEQFQRLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ER9</accession>
    <name>Q32ER9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yceP</name>
        <name evidence="1" type="ordered locus">SDY_2095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000414438.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403677.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ER9"/>
    <dbReference type="SMR" id="Q32ER9"/>
    <dbReference type="STRING" id="300267.SDY_2095"/>
    <dbReference type="EnsemblBacteria" id="ABB62186">
        <property type="protein sequence ID" value="ABB62186"/>
        <property type="gene ID" value="SDY_2095"/>
    </dbReference>
    <dbReference type="GeneID" id="66508885"/>
    <dbReference type="KEGG" id="sdy:SDY_2095"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2520"/>
    <dbReference type="HOGENOM" id="CLU_193121_0_0_6"/>
    <dbReference type="OMA" id="YILQAGI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025730">
        <property type="entry name" value="Biofilm_BssS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13991">
        <property type="entry name" value="BssS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="9664" checksum="1D7103C964E5D5FF" modified="2005-12-06" version="1">MEKNNEVIQTHPLVGWDISTVDSYDALMLRLHYQTPNKSEQEGTEVGQTLWLTTDVARQFISILEAGIAKIESGDFQVNEYRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F77</accession>
    <name>Q32F77_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403519.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F77"/>
    <dbReference type="STRING" id="300267.SDY_1922"/>
    <dbReference type="EnsemblBacteria" id="ABB62028">
        <property type="protein sequence ID" value="ABB62028"/>
        <property type="gene ID" value="SDY_1922"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1922"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2317"/>
    <dbReference type="HOGENOM" id="CLU_1255248_0_0_6"/>
    <dbReference type="OMA" id="DEIAYIW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="220" mass="25280" checksum="6534F03B4C7BE509" modified="2005-12-06" version="1">MLKITPNFAQERGLNQLRHEWKQHRTYLMYALTGSGKTGLAAFVTAGMVERGMRVMFVCPYTILLNQTAERFTEYGLPWEEISFVWRDHPNYDPSRLIQIASADTLIRREFPDNIDLLIIDEAHMKRRALLEVIRDKDIRVLGLSGTPFAAWMGKYYECLIKPTTIRELIQRGDLSDYEFFAPSMPDLACVKTSNTVFGRDYNEEQLASIMGSSDLVGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F80</accession>
    <name>Q32F80_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403516.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F80"/>
    <dbReference type="STRING" id="300267.SDY_1919"/>
    <dbReference type="EnsemblBacteria" id="ABB62025">
        <property type="protein sequence ID" value="ABB62025"/>
        <property type="gene ID" value="SDY_1919"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1919"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2312"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15394" checksum="B74125B4D3513277" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNISMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FE8</accession>
    <name>CNU_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>OriC-binding nucleoid-associated protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>H-NS/StpA-binding protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Transcription modulator YdgT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">cnu</name>
        <name type="synonym">ydgT</name>
        <name type="ordered locus">SDY_1848</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Modifies the set of genes regulated by H-NS; Hha and cnu (YdgT) increase the number of genes bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex on DNA. The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms complexes with both H-NS and StpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Hha/YmoA/Cnu family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000217950.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403448.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FE8"/>
    <dbReference type="SMR" id="Q32FE8"/>
    <dbReference type="STRING" id="300267.SDY_1848"/>
    <dbReference type="EnsemblBacteria" id="ABB61957">
        <property type="protein sequence ID" value="ABB61957"/>
        <property type="gene ID" value="SDY_1848"/>
    </dbReference>
    <dbReference type="GeneID" id="66674483"/>
    <dbReference type="KEGG" id="sdy:SDY_1848"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2227"/>
    <dbReference type="HOGENOM" id="CLU_190629_0_0_6"/>
    <dbReference type="OMA" id="PKSVWHF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007985">
        <property type="entry name" value="Hemolysn_expr_modulating_HHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036666">
        <property type="entry name" value="HHA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05321">
        <property type="entry name" value="HHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68989">
        <property type="entry name" value="SSF68989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000305053" description="OriC-binding nucleoid-associated protein">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with H-NS" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P64467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="71" mass="8417" checksum="CE9FF2E890E78219" modified="2005-12-06" version="1">MTVQDYLLKFRKISSLESLEKLYDHLNYTLTDDQELINMYRAADHRRAELVSGGRLFDLGQVPKSVWHYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FG7</accession>
    <name>Q32FG7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">fumC</name>
        <name evidence="5" type="ordered locus">SDY_1827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001099094.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403429.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FG7"/>
    <dbReference type="STRING" id="300267.SDY_1827"/>
    <dbReference type="EnsemblBacteria" id="ABB61938">
        <property type="protein sequence ID" value="ABB61938"/>
        <property type="gene ID" value="SDY_1827"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1827"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2200"/>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_6"/>
    <dbReference type="OMA" id="HDSMGEV"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="12"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="408"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="467" mass="50555" checksum="9776E518D52E108C" modified="2005-12-06" version="1">MNTVRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLSEKSRAFADIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVIAPNKFEALATCDALVQAHGALKGVAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNPHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQMVGSMKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FH6</accession>
    <name>Q32FH6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000267654.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403420.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FH6"/>
    <dbReference type="SMR" id="Q32FH6"/>
    <dbReference type="STRING" id="300267.SDY_1818"/>
    <dbReference type="EnsemblBacteria" id="ABB61929">
        <property type="protein sequence ID" value="ABB61929"/>
        <property type="gene ID" value="SDY_1818"/>
    </dbReference>
    <dbReference type="GeneID" id="66674381"/>
    <dbReference type="KEGG" id="sdy:SDY_1818"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2191"/>
    <dbReference type="HOGENOM" id="CLU_036517_0_0_6"/>
    <dbReference type="OMA" id="GSFYSAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="PTHR12149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="286" mass="32475" checksum="2D7AAA4AE229F787" modified="2005-12-06" version="1">MWQAISRLLSEQLGEGEIELRNELPGGEVHAAWHLRYAGHDFFVKCDERELLPGFTAEADQLELLSRSKTVTVPKVWAVGADRDYSFLVMDYLPPRPLDAHSAFILGQQIARLHQWSDQPQFGLDFDNSLSTTPQPNTWQRRWSTFFAEQRIGWQLELAAEKGIAFGNIDAIVEHIQQRLASHQPQPSLLHGDLWSGNCALGPDGPYIFDPACYWGDRECDLAMLPLHTEQPPQIYDGYQSVSPLPADFLERQPVYQLYTLLNRARLFGGQHLVIAQQSLDRLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FK1</accession>
    <name>Q32FK1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ydiT</name>
        <name evidence="7" type="ordered locus">SDY_1792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Could be a 3Fe-4S cluster-containing protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial-type ferredoxin family. FixX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000081064.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403395.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FK1"/>
    <dbReference type="STRING" id="300267.SDY_1792"/>
    <dbReference type="EnsemblBacteria" id="ABB61904">
        <property type="protein sequence ID" value="ABB61904"/>
        <property type="gene ID" value="SDY_1792"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1792"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2162"/>
    <dbReference type="HOGENOM" id="CLU_163428_0_0_6"/>
    <dbReference type="OMA" id="RFDSAGC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012206">
        <property type="entry name" value="Fd_FixX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43082">
        <property type="entry name" value="PTHR43082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036548">
        <property type="entry name" value="Fdx_FixX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="97" mass="10698" checksum="C1E6984E2F7131CA" modified="2005-12-06" version="1">MSQNATVNIDIKLGVNKFHVDEGHPHIILAANPDINEFRKLMKACPAGLYKQDDAGNIHFDSAGCLECGTCRVLCGNTILKQWQYPAGTFGIDFRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FL6</accession>
    <name>Q32FL6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase, ATP-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrpA</name>
        <name evidence="3" type="ordered locus">SDY_1774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403380.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FL6"/>
    <dbReference type="STRING" id="300267.SDY_1774"/>
    <dbReference type="EnsemblBacteria" id="ABB61889">
        <property type="protein sequence ID" value="ABB61889"/>
        <property type="gene ID" value="SDY_1774"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1774"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2138"/>
    <dbReference type="HOGENOM" id="CLU_001832_3_3_6"/>
    <dbReference type="OMA" id="YERVTLY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="68"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="255"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1281" mass="146640" checksum="A747E0C9138A7EED" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FN8</accession>
    <name>Q32FN8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FN8"/>
    <dbReference type="STRING" id="300267.SDY_1750"/>
    <dbReference type="EnsemblBacteria" id="ABB61867">
        <property type="protein sequence ID" value="ABB61867"/>
        <property type="gene ID" value="SDY_1750"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1750"/>
    <dbReference type="HOGENOM" id="CLU_122773_0_0_6"/>
    <dbReference type="OMA" id="YEYAIVE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="8885" checksum="E21AB643115A01B8" modified="2005-12-06" version="1">MLKHHVLIDGNAVVRGGPILLDEHVVIQGESRITGAVIIENHVELTDHPVVEAFDGDTVHVRGPKVINGEERITRTPLAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FR7</accession>
    <name>Q32FR7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="1">2.6.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pabB</name>
        <name evidence="6" type="ordered locus">SDY_1718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000854998.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403329.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FR7"/>
    <dbReference type="STRING" id="300267.SDY_1718"/>
    <dbReference type="EnsemblBacteria" id="ABB61838">
        <property type="protein sequence ID" value="ABB61838"/>
        <property type="gene ID" value="SDY_1718"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1718"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2072"/>
    <dbReference type="HOGENOM" id="CLU_006493_7_2_6"/>
    <dbReference type="OMA" id="HGRMDTS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005802">
        <property type="entry name" value="ADC_synth_comp_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00553">
        <property type="entry name" value="pabB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="5">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="4">
        <location>
            <begin position="190"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="453" mass="51023" checksum="91854114C5D246EB" modified="2005-12-06" version="1">MKTLSPAVITLPWRQDAAEFYFSRLSHLPWAMLLHSGYADHPYSRFDIVVAEPICTLTTFGKETVVSEREKRTTTTDDPLQVLQQVLDRADIRPTHNEDLPFQGGALGLFGYDLGRRFESLPEIAEQDIVLPDMAVGIYDWALIVDHQRHTVSLLSHNDVNARRARLESQQFSPQEDFTLTSDWQSNMTREQYGEKFRQVQEYLHSGDCYQVNLAQRFHATYSGDEWQAFLQLNQANRAPFSAFLRLEQGAILSLSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQAEKLANSAKDRAENLMIVDLMRNDIGRVAVAGSVKVPELFVVEPFPAVHHLVSTITAQLPEQLHASDLLRAAFPGGSITGAPKVRAMEIIDELEPQRRNAWCGSIGYLSFCGNMDTSITIRTLTAINGQIFCSAGGGIVADSQEEAEYQETFDKVNKILRQLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FV7</accession>
    <name>Q32FV7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FV7"/>
    <dbReference type="EnsemblBacteria" id="ABB61798">
        <property type="protein sequence ID" value="ABB61798"/>
        <property type="gene ID" value="SDY_1677"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1677"/>
    <dbReference type="HOGENOM" id="CLU_027402_14_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="176" mass="20099" checksum="E49D30144BAC2D05" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FW6</accession>
    <name>Q32FW6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403280.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FW6"/>
    <dbReference type="EnsemblBacteria" id="ABB61789">
        <property type="protein sequence ID" value="ABB61789"/>
        <property type="gene ID" value="SDY_1668"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1668"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2014"/>
    <dbReference type="HOGENOM" id="CLU_173164_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="13046" checksum="55601041251B3BA2" modified="2005-12-06" version="1">MQLMLFNLFPPALKLNTGLAILSPGAFEVHSDGIDEDNELFHYTIKKAYTPYNILTYKTEEVVNQRNIKVKNMTLDEINNTYCNNDYYNQAIREEPIDLLDRSFSSSSWPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FZ4</accession>
    <name>Q32FZ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ymjA</name>
        <name evidence="1" type="ordered locus">SDY_1637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001015099.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403252.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FZ4"/>
    <dbReference type="STRING" id="300267.SDY_1637"/>
    <dbReference type="EnsemblBacteria" id="ABB61761">
        <property type="protein sequence ID" value="ABB61761"/>
        <property type="gene ID" value="SDY_1637"/>
    </dbReference>
    <dbReference type="GeneID" id="66674878"/>
    <dbReference type="KEGG" id="sdy:SDY_1637"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1973"/>
    <dbReference type="HOGENOM" id="CLU_2568610_0_0_6"/>
    <dbReference type="OMA" id="QNEMARE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020251">
        <property type="entry name" value="Uncharacterised_YmjA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10820">
        <property type="entry name" value="DUF2543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="9307" checksum="1E07834C1BA41FE1" modified="2005-12-06" version="1">MNHDIPLKYFDIADEYATECAEPVADAERTPLAHYFQLLLTRLMNNEEISEEAQHEMAAEAGINPVRIDEIAEFLNQWGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G22</accession>
    <name>Q32G22_SHIDS</name>
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        <submittedName>
            <fullName evidence="11">Formate dehydrogenase-N, nitrate-inducible, cytochrome B556(Fdn) gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fdnI</name>
        <name evidence="11" type="ordered locus">SDY_1606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the formate dehydrogenase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G22"/>
    <dbReference type="STRING" id="300267.SDY_1606"/>
    <dbReference type="EnsemblBacteria" id="ABB61733">
        <property type="protein sequence ID" value="ABB61733"/>
        <property type="gene ID" value="SDY_1606"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1606"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1930"/>
    <dbReference type="HOGENOM" id="CLU_091368_1_1_6"/>
    <dbReference type="OMA" id="TIMSMIF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009326">
        <property type="term" value="C:formate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006471">
        <property type="entry name" value="Formate_DH_gsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01583">
        <property type="entry name" value="formate-DH-gamm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="10">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB61733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="217" mass="25368" checksum="191DA7651E57C505" modified="2005-12-06" version="1">MGKSKMIVRTKFIDRACHWTVVICFFLVALSGISFFFPTLQWLTQTFGTPQMGRILHPFFGIAIFVALMFMFVRFVHHNIPDKKDIPWLLNIVEVLKGNEHKVADVGKYNAGQKMMFWSIMSMIFVLLVTGVIIWRPYFAQYFPMQVVRYSLLIHAATGIILIHAILIHMYMAFWVKGSIKGMIEGKVSRRWAKKHHPRWYREIEKAEAKKESEEGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G29</accession>
    <name>MARC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>UPF0056 inner membrane protein MarC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">marC</name>
        <name type="ordered locus">SDY_1598</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000885033.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403217.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G29"/>
    <dbReference type="STRING" id="300267.SDY_1598"/>
    <dbReference type="EnsemblBacteria" id="ABB61726">
        <property type="protein sequence ID" value="ABB61726"/>
        <property type="gene ID" value="SDY_1598"/>
    </dbReference>
    <dbReference type="GeneID" id="66674617"/>
    <dbReference type="KEGG" id="sdy:SDY_1598"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1920"/>
    <dbReference type="HOGENOM" id="CLU_079909_2_0_6"/>
    <dbReference type="OMA" id="MMAIVML"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000343827" description="UPF0056 inner membrane protein MarC">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="218"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="221" mass="23617" checksum="7957FF9403C5F135" modified="2005-12-06" version="1">MLDLFKAIGLGLVVLLPLANPLTTVALFLGLAGNMNSAERNRQSLMASVYVFAIMMVAYYAGQLVMDTFGISIPGLRIAGGLIVAFIGFRMLFPQQKAIDSPEAKSKSEELEDEPSANIAFVPLAMPSTAGPGTIAMIISSASTVRQSSTFADWVLMVAPPLIFFLVAVILWGSLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGILEIIKTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G44</accession>
    <name>Q32G44_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G44"/>
    <dbReference type="EnsemblBacteria" id="ABB61711">
        <property type="protein sequence ID" value="ABB61711"/>
        <property type="gene ID" value="SDY_1581"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1581"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="85" mass="9412" checksum="900B512D7E473B61" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITNYRCGLSSFYPERGRNAGFSSGTYCIDGLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G49</accession>
    <name>Q32G49_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G49"/>
    <dbReference type="EnsemblBacteria" id="ABB61706">
        <property type="protein sequence ID" value="ABB61706"/>
        <property type="gene ID" value="SDY_1573"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1573"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="75" mass="8458" checksum="5065141DB79991A4" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITIKRMKKLFTFTASLALRLKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G56</accession>
    <name>Q32G56_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bioD</name>
        <name evidence="6" type="ordered locus">SDY_1563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G56"/>
    <dbReference type="STRING" id="300267.SDY_1563"/>
    <dbReference type="EnsemblBacteria" id="ABB61699">
        <property type="protein sequence ID" value="ABB61699"/>
        <property type="gene ID" value="SDY_1563"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1563"/>
    <dbReference type="HOGENOM" id="CLU_072551_0_0_6"/>
    <dbReference type="OMA" id="WRTLMND"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="235" mass="25401" checksum="C0C96A6581D2A581" modified="2005-12-06" version="1">MELVMLKRFFITGTDTSVGKTVVSRALLQALASQGKTVAGYKPVAKGSKETPEGLRNKDALVLQSVSTIELPYEAVNPIALSEEESSVAHSCPINYTLISNGLANLTEKVDHVVVEGTGGWCSLMNDLRPLSEWVVQEQLPVLMVVGIQEGCINHALLTAQAIANDGLPLIGWVANRINPGLAHYAEIIDVLGKKLPAPLIGELPYLPRAEQRELGQYIRLAMLRSVLAVDRVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G73</accession>
    <name>Q32G73_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydgC</name>
        <name evidence="2" type="ordered locus">SDY_1546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000524868.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403173.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G73"/>
    <dbReference type="STRING" id="300267.SDY_1546"/>
    <dbReference type="EnsemblBacteria" id="ABB61682">
        <property type="protein sequence ID" value="ABB61682"/>
        <property type="gene ID" value="SDY_1546"/>
    </dbReference>
    <dbReference type="GeneID" id="66674502"/>
    <dbReference type="KEGG" id="sdy:SDY_1546"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1855"/>
    <dbReference type="HOGENOM" id="CLU_140962_0_0_6"/>
    <dbReference type="OMA" id="YFVYLAT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009707">
        <property type="entry name" value="GlpM/YdgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06942">
        <property type="entry name" value="GlpM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="111" mass="12323" checksum="8690061D033E5873" modified="2005-12-06" version="1">MGLVIKAALGALVVLLIGVLAKTKNYYIAGLIPLFPTFALIAHYIVASERGIEALRATIIFSMWSIIPYFVYLVSLWYFTGMMRLPAAFVGSVACWGISAWVLIICWIKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G83</accession>
    <name>Q32G83_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G83"/>
    <dbReference type="EnsemblBacteria" id="ABB61672">
        <property type="protein sequence ID" value="ABB61672"/>
        <property type="gene ID" value="SDY_1536"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1536"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_2_6"/>
    <dbReference type="OMA" id="TQRTRIK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="58" mass="7012" checksum="CB654210F782A9B3" modified="2005-12-06" version="1">MPKDKHLTGKIFTQRIEHNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GA8</accession>
    <name>SELD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Selenide, water dikinase</fullName>
            <ecNumber evidence="1">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Selenium donor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Selenophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">selD</name>
        <name type="ordered locus">SDY_1509</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001298241.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403138.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GA8"/>
    <dbReference type="SMR" id="Q32GA8"/>
    <dbReference type="STRING" id="300267.SDY_1509"/>
    <dbReference type="EnsemblBacteria" id="ABB61647">
        <property type="protein sequence ID" value="ABB61647"/>
        <property type="gene ID" value="SDY_1509"/>
    </dbReference>
    <dbReference type="GeneID" id="67415533"/>
    <dbReference type="KEGG" id="sdy:SDY_1509"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1803"/>
    <dbReference type="HOGENOM" id="CLU_032859_0_1_6"/>
    <dbReference type="OMA" id="DNEPKYG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00625">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023061">
        <property type="entry name" value="SelD_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="PTHR10256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0711">Selenium</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000318659" description="Selenide, water dikinase">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00625"/>
        </source>
    </evidence>
    <sequence length="347" mass="36673" checksum="58F544785D01361E" modified="2005-12-06" version="1">MSENSIRLTQYSHGAGCGCKISPKVLETILHSEQAKFVDPNLLVGNETRDDAAVYDLGNGTSVISTTDFFMPIVDNPFDFGRIAATNAISDIFAMGGKPIMAIAILGWPINKLSPEIAREVTEGGRYACRQAGIALAGGHSIDAPEPIFGLAVTGIVPTERVKKNSTAQAGCKLFLTKPLGIGVLTTAEKKSLLKPEHQGLATEVMCRMNIAGASFANIEGVKAMTDVTGFGLLGHLSEMCQGAGVQARVDYDAIPKLPGVEEYIKLGAVPGGTERNFASYGHLMGEMPREVRDLLCDPQTSGGLLLAVMPEAENEVKATAAEFGIELTAIGELVPARGGRAMVEIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GI6</accession>
    <name>TTCA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-cytidine(32) 2-sulfurtransferase</fullName>
            <ecNumber evidence="1">2.8.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Two-thiocytidine biosynthesis protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA 2-thiocytidine biosynthesis protein TtcA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ttcA</name>
        <name type="ordered locus">SDY_1426</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:57048"/>
            <dbReference type="Rhea" id="RHEA-COMP:10288"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:14821"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:141453"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:57049"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TtcA family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001157400.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403060.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GI6"/>
    <dbReference type="SMR" id="Q32GI6"/>
    <dbReference type="STRING" id="300267.SDY_1426"/>
    <dbReference type="EnsemblBacteria" id="ABB61569">
        <property type="protein sequence ID" value="ABB61569"/>
        <property type="gene ID" value="SDY_1426"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1426"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1697"/>
    <dbReference type="HOGENOM" id="CLU_026481_0_0_6"/>
    <dbReference type="OMA" id="MNLDQKQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01850">
        <property type="entry name" value="TtcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012089">
        <property type="entry name" value="tRNA_Cyd_32_2_STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000348850" description="tRNA-cytidine(32) 2-sulfurtransferase">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PP-loop motif" evidence="1">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01850"/>
        </source>
    </evidence>
    <sequence length="311" mass="35517" checksum="DA780CEB9507C8AC" modified="2005-12-06" version="1">MQENQQITKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQKQPGFPEHVLLEYLEKLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIQRFADAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQNVVPSHLCDSNLFDFKGITHGSEVVNGGDLAFDREEIPLQPAGWQPEEDENQLDELRLNVVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GR8</accession>
    <name>Q32GR8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="5 8">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">btuR</name>
        <name evidence="10" type="ordered locus">SDY_1340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="5 8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001278902.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402978.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GR8"/>
    <dbReference type="STRING" id="300267.SDY_1340"/>
    <dbReference type="EnsemblBacteria" id="ABB61487">
        <property type="protein sequence ID" value="ABB61487"/>
        <property type="gene ID" value="SDY_1340"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1340"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1589"/>
    <dbReference type="HOGENOM" id="CLU_088595_0_0_6"/>
    <dbReference type="OMA" id="HAMGEGF"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025826">
        <property type="entry name" value="Co_AT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12557">
        <property type="entry name" value="Co_AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Co_AT_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="196" mass="22045" checksum="02CF2DD9D75FEFB9" modified="2005-12-06" version="1">MSDERYQQRQQRVKEKVDARVAQAQDERGIIIVFTGNGKGKTTAAFGTATRAVGHGKKVGVVQFIKGTWPNGERNLLEPHGVEFQVMATGFTWDTQNRESDTAACREVWQHAKRMLADSSLDMVLLDELTYMVAYDYLPLEEVMQALNERPHQQTVILTGRGCHRDILELADTVSELRPIKHAFDAGVKAQIGIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GS0</accession>
    <name>Q32GS0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001110815.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402976.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GS0"/>
    <dbReference type="STRING" id="300267.SDY_1338"/>
    <dbReference type="EnsemblBacteria" id="ABB61485">
        <property type="protein sequence ID" value="ABB61485"/>
        <property type="gene ID" value="SDY_1338"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1338"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1587"/>
    <dbReference type="HOGENOM" id="CLU_114038_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="141" mass="14827" checksum="D001DE789D8B1448" modified="2005-12-06" version="1">MPAGYFSAVFLTGYLTGMGYIFLPKFTQTGQQRYAHGEAIVNYLARKEAATHSGRRRKGETRKLDYALLGWAVSANLGREWVARITPSLTAAVSAPEIARSGVLFSLQMHLSLGANTSLLGRSYSGGAAGRGAGGGGGGGW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GT0</accession>
    <name>TRPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="1">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpA</name>
        <name type="ordered locus">SDY_1328</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000443088.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402966.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GT0"/>
    <dbReference type="SMR" id="Q32GT0"/>
    <dbReference type="STRING" id="300267.SDY_1328"/>
    <dbReference type="EnsemblBacteria" id="ABB61475">
        <property type="protein sequence ID" value="ABB61475"/>
        <property type="gene ID" value="SDY_1328"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1328"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1578"/>
    <dbReference type="HOGENOM" id="CLU_016734_0_4_6"/>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_1000018281" description="Tryptophan synthase alpha chain">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <sequence length="268" mass="28662" checksum="028BB556A6FFFA59" modified="2005-12-06" version="1">MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCIEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKAFVQPMKAATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H01</accession>
    <name>Q32H01_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ychM</name>
        <name evidence="7" type="ordered locus">SDY_1255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402895.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H01"/>
    <dbReference type="STRING" id="300267.SDY_1255"/>
    <dbReference type="EnsemblBacteria" id="ABB61404">
        <property type="protein sequence ID" value="ABB61404"/>
        <property type="gene ID" value="SDY_1255"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1255"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1492"/>
    <dbReference type="HOGENOM" id="CLU_003182_13_1_6"/>
    <dbReference type="OMA" id="VTNKFPI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="440"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="550" mass="58385" checksum="E2B68989520EB995" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H80</accession>
    <name>Q32H80_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yecN</name>
        <name evidence="5" type="ordered locus">SDY_1168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H80"/>
    <dbReference type="STRING" id="300267.SDY_1168"/>
    <dbReference type="EnsemblBacteria" id="ABB61325">
        <property type="protein sequence ID" value="ABB61325"/>
        <property type="gene ID" value="SDY_1168"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1168"/>
    <dbReference type="HOGENOM" id="CLU_134926_1_0_6"/>
    <dbReference type="OMA" id="LPWEQIF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="SSF161084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="141" mass="16227" checksum="784C0CEFBFA933A1" modified="2005-12-06" version="1">MPSAILKGVCMVSALYAVLSALLLMKFSFDVVRLRMQYRVAYGDGGFSELQSAIRIHGNAVEYIPIAIVLMLFMEMNGAETWMVHICGIVLLAGRLMHYYGFHHRLFRWRRSGMSATWCALLLMVLANLWYMPWELVFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I13</accession>
    <name>Q32I13_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair system specific for alkylated DNA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alkB</name>
        <name evidence="7" type="ordered locus">SDY_0864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000884975.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402533.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I13"/>
    <dbReference type="STRING" id="300267.SDY_0864"/>
    <dbReference type="EnsemblBacteria" id="ABB61042">
        <property type="protein sequence ID" value="ABB61042"/>
        <property type="gene ID" value="SDY_0864"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0864"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.998"/>
    <dbReference type="HOGENOM" id="CLU_039677_1_1_6"/>
    <dbReference type="OMA" id="NCGPLGW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="PTHR16557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00568">
        <property type="entry name" value="alkb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="113"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="216" mass="24007" checksum="F4EFFCEE88793083" modified="2005-12-06" version="1">MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDTNDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTGDCRYNLTFRQAGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I21</accession>
    <name>Q32I21_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sensor histidine kinase RcsC</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">rcsC</name>
        <name evidence="9" type="ordered locus">SDY_0856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane-associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with RcsD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Autophosphorylated. Activation probably requires a transfer of a phosphate group from a His in the transmitter domain to an Asp in the receiver domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RcsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I21"/>
    <dbReference type="STRING" id="300267.SDY_0856"/>
    <dbReference type="EnsemblBacteria" id="ABB61034">
        <property type="protein sequence ID" value="ABB61034"/>
        <property type="gene ID" value="SDY_0856"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0856"/>
    <dbReference type="HOGENOM" id="CLU_000445_15_6_6"/>
    <dbReference type="OMA" id="TRCWLAV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00979">
        <property type="entry name" value="RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030856">
        <property type="entry name" value="RcsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038388">
        <property type="entry name" value="RcsC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019017">
        <property type="entry name" value="Sig_transdc_His_kin_a/b-loop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09456">
        <property type="entry name" value="RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51426">
        <property type="entry name" value="ABL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="460"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="ABL" evidence="8">
        <location>
            <begin position="689"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="810"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="4">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4 5">
        <location>
            <position position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="933" mass="104570" checksum="7E5142CA71E6DA64" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IF5</accession>
    <name>Q32IF5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IF5"/>
    <dbReference type="STRING" id="300267.SDY_0718"/>
    <dbReference type="EnsemblBacteria" id="ABB60902">
        <property type="protein sequence ID" value="ABB60902"/>
        <property type="gene ID" value="SDY_0718"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0718"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_1_6"/>
    <dbReference type="OMA" id="KHNDIFA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="173" mass="20188" checksum="864AFA35FE713352" modified="2005-12-06" version="1">MTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKPGGVMFHSDQGSHYTSRQFRQLLWRYQIRQSMSRRGNCRDNSPMERFFRSLKNEWMPVVGYVSFSEAAHAITDYIVGYYSALRPHEYNGGLPPNESENRYWKNSNSVASFC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32II1</accession>
    <name>TOLB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tol-Pal system protein TolB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tolB</name>
        <name type="ordered locus">SDY_0688</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378599.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402365.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32II1"/>
    <dbReference type="SMR" id="Q32II1"/>
    <dbReference type="STRING" id="300267.SDY_0688"/>
    <dbReference type="EnsemblBacteria" id="ABB60876">
        <property type="protein sequence ID" value="ABB60876"/>
        <property type="gene ID" value="SDY_0688"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0688"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.802"/>
    <dbReference type="HOGENOM" id="CLU_047123_0_0_6"/>
    <dbReference type="OMA" id="VREPSWG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00671">
        <property type="entry name" value="TolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014167">
        <property type="entry name" value="Tol-Pal_TolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007195">
        <property type="entry name" value="TolB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04052">
        <property type="entry name" value="TolB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02800">
        <property type="entry name" value="propeller_TolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000259089" description="Tol-Pal system protein TolB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00671"/>
        </source>
    </evidence>
    <sequence length="430" mass="45986" checksum="564BD942228D7B43" modified="2005-12-06" version="1" precursor="true">MKQALRVAFGFLILWASVLHAEVRIVIDSGVDSGRPIGVVPFQWAGPGAAPEDIGGIVAADLRNSGKFNPLDRARLPQQPGSAQEVQPAAWSALGIDAVVVGQVTPNPDGSYNVAYQLVDTGGAPGTVLAQNSYKVNKQWLRYASHTASDEVFEKLTGIKGAFRTRIAYVVQTNGGQFPYELRVSDYDGYNQFVVHRSPQPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGAVRQVASFPRHNGAPAFSPDGSKLAFALSKTGSLNLYVMDLASGQIRQVTDGRSNNTEPTWFPDSQNLAFTSDQAGRPQVYKVNINGGAPQRITWEGSQNQDADVSSDGKFMVMVSSNGGQQHIAKQDLATGGVQVLSSTFLDETPSLAPNGTMVIYSSSQGMGSVLNLVSTDGRFKARLPATDGQVKFPAWSPYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IM0</accession>
    <name>PXPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name type="ordered locus">SDY_0648</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000687138.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402326.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IM0"/>
    <dbReference type="SMR" id="Q32IM0"/>
    <dbReference type="STRING" id="300267.SDY_0648"/>
    <dbReference type="EnsemblBacteria" id="ABB60837">
        <property type="protein sequence ID" value="ABB60837"/>
        <property type="gene ID" value="SDY_0648"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0648"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.756"/>
    <dbReference type="HOGENOM" id="CLU_069535_0_0_6"/>
    <dbReference type="OMA" id="DRTYKQD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000045222" description="5-oxoprolinase subunit A">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <sequence length="244" mass="25871" checksum="D2A617275B7DE0B4" modified="2005-12-06" version="1">MKIDLNADLGEGCASDAELLTLVSSANIACGFHAGDAQTMQACVREAIKNGVAIGAHPSFPDRENFGRSAMQLPPETVYAQTLYQIGALATIARAQGGVMRHVKPHGMLYNQAAKEAQLADAIARAVYACDPALVLVGLAGSELIRAGKQYGLTTREEVFADRGYQADGSLVPRNQPGALIENEEQALAQTLEMVQHGRVKSITGEWATVTAQTVCLHGDGEHALAFARRLRSTFAEKGIVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IN6</accession>
    <name>Q32IN6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pgm</name>
        <name evidence="14" type="ordered locus">SDY_0628</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:58225"/>
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        </reaction>
    </comment>
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        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
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    <dbReference type="EnsemblBacteria" id="ABB60821">
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    </dbReference>
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    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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            <begin position="40"/>
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        </location>
    </feature>
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        </location>
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        <source>
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    <sequence length="546" mass="58361" checksum="380FAC075BF38852" modified="2005-12-06" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="ABB60738">
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ABB60738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="315" mass="35253" checksum="63960C5D49CFA912" modified="2005-12-06" version="1">MREAIALKTERLYGYQPDADSDITVTAGATEALYAAITALVRNGDEVICFDPSYDSYAPAIALSGGIVKRMALQPPHFRVDWQEFAALLSERTRLVILNTPHNPSATVWQQADFAALWQAIAGHEIFVISDEVYEHINFSQQGHASVLAHPQLRERAVAVSSFGKTYHMTGWKVGYCVAPAPISAEIRKVHQYLTFSVNTPAQLALADMLRAEPEHYLALPDFYRQKRDILVNALSESRLEILPCEGTYFLLVDYSEVSTLDDVEFCQWLTREHGVAAIPLSVFCADPFPHKLIRLCFAKKESTLLAAAERLRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J02</accession>
    <name>Q32J02_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Autotransporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ABB60705">
        <property type="protein sequence ID" value="ABB60705"/>
        <property type="gene ID" value="SDY_0498"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0498"/>
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    <dbReference type="HOGENOM" id="CLU_115342_0_0_6"/>
    <dbReference type="OMA" id="QDWSANG"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006315">
        <property type="entry name" value="OM_autotransptr_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003991">
        <property type="entry name" value="Pertactin_virulence_factor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03797">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01484">
        <property type="entry name" value="PRTACTNFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00869">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103515">
        <property type="entry name" value="SSF103515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01414">
        <property type="entry name" value="autotrans_barl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51208">
        <property type="entry name" value="AUTOTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autotransporter" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="227" mass="24375" checksum="8760E6AE790E6104" modified="2005-12-06" version="1">MVGVDTKIDGNNAKWIVGAAAGFAKGDMNDRSGQVDQDSQTAYIYSSAHFANNVFVDGSLSYSHFNNDLSASMSNGTYVDGSTNSDAWGFGLKAGYDFKLGDAGYVTPYGSISGLFQSGDDYQLSNDMKVDGQSYDSMRYELGVDAGYTFTYSEDQALTPYFKQAYVYDDSNNDNDVNGDSIDNGTEGSAVRVGLGTQFSFTKNFSAYTDANYLGGGDVDQDWSANG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J06</accession>
    <name>GCS2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="1">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="1">GCS 2</shortName>
            <shortName evidence="1">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ybdK</name>
        <name type="ordered locus">SDY_0494</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001131209.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402190.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J06"/>
    <dbReference type="SMR" id="Q32J06"/>
    <dbReference type="STRING" id="300267.SDY_0494"/>
    <dbReference type="EnsemblBacteria" id="ABB60701">
        <property type="protein sequence ID" value="ABB60701"/>
        <property type="gene ID" value="SDY_0494"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0494"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.583"/>
    <dbReference type="HOGENOM" id="CLU_044848_1_1_6"/>
    <dbReference type="OMA" id="LIFGLHV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000255815" description="Putative glutamate--cysteine ligase 2">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <sequence length="372" mass="41673" checksum="4CF121FF0FDA4245" modified="2005-12-06" version="1">MPLSDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNEITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAAADHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYPIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPYTGDRRPLTEDTLRLLEKIAPSAHKIAASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J09</accession>
    <name>Q32J09_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxygen-insensitive NAD(P)H nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nfnB</name>
        <name evidence="3" type="ordered locus">SDY_0491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000351475.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402187.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J09"/>
    <dbReference type="STRING" id="300267.SDY_0491"/>
    <dbReference type="EnsemblBacteria" id="ABB60698">
        <property type="protein sequence ID" value="ABB60698"/>
        <property type="gene ID" value="SDY_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0491"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.580"/>
    <dbReference type="HOGENOM" id="CLU_070764_4_1_6"/>
    <dbReference type="OMA" id="PWHFVVA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02149">
        <property type="entry name" value="NfsB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033878">
        <property type="entry name" value="NfsB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="217" mass="23835" checksum="0BB96829263B7BD0" modified="2005-12-06" version="1">MDIISVALKRHSTKAFDASKKLTPEQAEQIKTLLQYSPSSTNSQPWHFIVASTEEGKARVAKSAAGNYVFNERKILDASLVVVFCAKTAMDDAWLKLVVDQEDADGRFATPEAKAANDKGRKFFADMHRKDLHDDAEWMAKQVYLNVGNFLLGVAALGLDAVPIEGFDAAILDAEFGLKEKGYTSLVVVPVGHHSVEDFNATLPKSRLPQNITLTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JJ7</accession>
    <name>Q32JJ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative protease maturation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybaU</name>
        <name evidence="4" type="ordered locus">SDY_0291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000969091.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401999.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JJ7"/>
    <dbReference type="STRING" id="300267.SDY_0291"/>
    <dbReference type="EnsemblBacteria" id="ABB60510">
        <property type="protein sequence ID" value="ABB60510"/>
        <property type="gene ID" value="SDY_0291"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0291"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.336"/>
    <dbReference type="HOGENOM" id="CLU_023843_1_1_6"/>
    <dbReference type="OMA" id="DNSQGWI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="266"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="623" mass="68205" checksum="4FD4D57068D04670" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JJ8</accession>
    <name>Q32JJ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybaV</name>
        <name evidence="4" type="ordered locus">SDY_0290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000680314.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401998.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JJ8"/>
    <dbReference type="STRING" id="300267.SDY_0290"/>
    <dbReference type="EnsemblBacteria" id="ABB60509">
        <property type="protein sequence ID" value="ABB60509"/>
        <property type="gene ID" value="SDY_0290"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0290"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.335"/>
    <dbReference type="HOGENOM" id="CLU_052011_3_1_6"/>
    <dbReference type="OMA" id="EANRDMI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220793" evidence="2">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="123" mass="12734" checksum="3CF7C7A4EA50B1C9" modified="2005-12-06" version="1">MKHGIKALLITLSLACAGMSHSALAAASVAKPTTVETKAEAPAAQSKAAVPAKASDEEGTRVSINNASAEELARAMNGVGLKKAQAIVSYREEYGPFKTVEDLKQVPGMGNSLVERNLAVLTL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JP9</accession>
    <name>RNH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease H</fullName>
            <shortName evidence="1">RNase H</shortName>
            <ecNumber evidence="1">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnhA</name>
        <name type="ordered locus">SDY_0233</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000917883.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401947.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JP9"/>
    <dbReference type="SMR" id="Q32JP9"/>
    <dbReference type="STRING" id="300267.SDY_0233"/>
    <dbReference type="EnsemblBacteria" id="ABB60458">
        <property type="protein sequence ID" value="ABB60458"/>
        <property type="gene ID" value="SDY_0233"/>
    </dbReference>
    <dbReference type="GeneID" id="66671496"/>
    <dbReference type="KEGG" id="sdy:SDY_0233"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.262"/>
    <dbReference type="HOGENOM" id="CLU_030894_6_0_6"/>
    <dbReference type="OMA" id="MQEIEIF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000074678" description="Ribonuclease H">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00408"/>
        </source>
    </evidence>
    <sequence length="155" mass="17597" checksum="B8EF81EEB2F94CBE" modified="2005-12-06" version="1">MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JS7</accession>
    <name>LPXB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="1">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxB</name>
        <name type="ordered locus">SDY_0198</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP</text>
            <dbReference type="Rhea" id="RHEA:22668"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57957"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58466"/>
            <dbReference type="ChEBI" id="CHEBI:78847"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LpxB family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000139657.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401919.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JS7"/>
    <dbReference type="SMR" id="Q32JS7"/>
    <dbReference type="STRING" id="300267.SDY_0198"/>
    <dbReference type="CAZy" id="GT19">
        <property type="family name" value="Glycosyltransferase Family 19"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60430">
        <property type="protein sequence ID" value="ABB60430"/>
        <property type="gene ID" value="SDY_0198"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0198"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.229"/>
    <dbReference type="HOGENOM" id="CLU_036577_3_0_6"/>
    <dbReference type="OMA" id="PTVWAWR"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00392">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00215">
        <property type="entry name" value="lpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000255224" description="Lipid-A-disaccharide synthase">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00392"/>
        </source>
    </evidence>
    <sequence length="382" mass="42351" checksum="A1B0E6B37EF4C5A8" modified="2005-12-06" version="1">MTEQRPLTIALVAGETSGDILGAGLIRALKERVPNARFVGVAGPRMQAEGCEAWYEIEELAVMGIVEVLGRLRRLLHIHADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDTHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAEVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKLLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K24</accession>
    <name>SGRR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional regulator SgrR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sgrR</name>
        <name type="ordered locus">SDY_0097</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001138610.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401822.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K24"/>
    <dbReference type="SMR" id="Q32K24"/>
    <dbReference type="STRING" id="300267.SDY_0097"/>
    <dbReference type="PRIDE" id="Q32K24"/>
    <dbReference type="EnsemblBacteria" id="ABB60333">
        <property type="protein sequence ID" value="ABB60333"/>
        <property type="gene ID" value="SDY_0097"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0097"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.115"/>
    <dbReference type="HOGENOM" id="CLU_017028_12_3_6"/>
    <dbReference type="OMA" id="WLTWQAE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01449">
        <property type="entry name" value="HTH_type_SgrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025370">
        <property type="entry name" value="SgrR_HTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023767">
        <property type="entry name" value="Tscrpt_reg_SgrR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12793">
        <property type="entry name" value="SgrR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000309252" description="HTH-type transcriptional regulator SgrR">
        <location>
            <begin position="1"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Solute-binding" evidence="1">
        <location>
            <begin position="163"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01449"/>
        </source>
    </evidence>
    <sequence length="552" mass="64107" checksum="AF382C41654227AF" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K79</accession>
    <name>Q32K79_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yadE</name>
        <name evidence="2" type="ordered locus">SDY_0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K79"/>
    <dbReference type="STRING" id="300267.SDY_0040"/>
    <dbReference type="EnsemblBacteria" id="ABB60278">
        <property type="protein sequence ID" value="ABB60278"/>
        <property type="gene ID" value="SDY_0040"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0040"/>
    <dbReference type="HOGENOM" id="CLU_030024_4_1_6"/>
    <dbReference type="OMA" id="TYWHPNF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="102"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32399" checksum="F11903F9A2E5B82D" modified="2005-12-06" version="1">MRYPILHKLKDRLNQTWYQVRIGDRLAYISALDAQPDNGLPVLTYHHILRDEENTRFRHTSTTTSVRAFNNQMAWLRDRGYATLSMVQLEGYVKNKINLPARAVVITFDDGLKSVSRYAYPVLKQYGMKATAFIVTSRIKRHPQKWEPKSLQFMSVSELNEIRDVFDFQSHTHFLHRVDGYRRPILLSRSEHNILFDFARSRRALAQFNPHVWYLSYPFGGFNDKAVKAANDAGFHLAVTSMKGKVKPGDNPLLLKRLYILRTDSLETMSRLVSNQPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q326P2</accession>
    <name>Q326P2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS629 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406204.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326P2"/>
    <dbReference type="SMR" id="Q326P2"/>
    <dbReference type="EnsemblBacteria" id="ABB64716">
        <property type="protein sequence ID" value="ABB64716"/>
        <property type="gene ID" value="SDY_P203"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P203"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5755"/>
    <dbReference type="HOGENOM" id="CLU_027402_41_1_6"/>
    <dbReference type="OMA" id="WSISNSM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="44"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="215" mass="23916" checksum="4B65E38DCCD0E794" modified="2005-12-06" version="1">MARCTVARLMAVMGLAGVLRGKKVRTTISRKAVAAGDRVNRQFVAERPDQLRVADFTYASTWQGFVYVAFIIDVFAGYIVGWRVSSSMETTFVLDALEQALWARRPSGTVHHSDKGSQYVSLAYTQRLKEAGLLASTGSTGDSYDNAMAESINGLYKAEVIHRKSWKNRAEVELATLTWVDWYNNRRLLERLGHTPPAEAEKAYYASIGNDDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Q3</accession>
    <name>Q326Q3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Spa29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">spa29</name>
        <name evidence="9" type="ordered locus">SDY_P192</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9 10">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Sd197</strain>
            <plasmid evidence="10">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000355395.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406193.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Q3"/>
    <dbReference type="SMR" id="Q326Q3"/>
    <dbReference type="EnsemblBacteria" id="ABB64705">
        <property type="protein sequence ID" value="ABB64705"/>
        <property type="gene ID" value="SDY_P192"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P192"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5744"/>
    <dbReference type="HOGENOM" id="CLU_063626_0_3_6"/>
    <dbReference type="OMA" id="CPQLNAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006304">
        <property type="entry name" value="T3SS_SpaR/YscT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01401">
        <property type="entry name" value="fliR_like_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="256" mass="28484" checksum="55E705C93EE2C57F" modified="2005-12-06" version="1">MDISSWFESIHVFLILLNGVFFRLAPLFFFLPFLNNGIISPSIRIPVIFLVASGLITSGKVDIGSSVFEHVYFLMFKEIIVGLLLSFCLSLPFWIFHAVGSIIDNQRGATLSSSIDPANGVDTSELAKFFNLFSAVVFLYSGGMVFILESIQLSYNICPLFSQCSFRVSNILTFLTLLASQAVILASPVMIVLLLSEVLLGVLSRFAPQMNAFSVSLTIKSLLAIFIIFICSSTIYFSKVQFFLGEHKFFTNLFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q326W0</accession>
    <name>Q326W0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yihA</name>
        <name evidence="2" type="ordered locus">SDY_P135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406136.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326W0"/>
    <dbReference type="EnsemblBacteria" id="ABB64648">
        <property type="protein sequence ID" value="ABB64648"/>
        <property type="gene ID" value="SDY_P135"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P135"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5691"/>
    <dbReference type="HOGENOM" id="CLU_082936_1_0_6"/>
    <dbReference type="OMA" id="HTERKEN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024402">
        <property type="entry name" value="DUF2726"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10881">
        <property type="entry name" value="DUF2726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2726" evidence="1">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="166" mass="19515" checksum="10FABC7AE9555149" modified="2005-12-06" version="1">MLMQLHAAGIRTGDAERILSSGEYWQRQKTLLTEREVSFMKGLFRIVDMKRWYLCPQVRGADIVQLNGNIRPRSRQWWQLFRMVSQWHVDVVIVELRSFSIVAAVELDDASHLRPERRRRDILLEEVLRQAGIPLLRSHDARKLQQMTGEWLNTTGADQQSPEHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q326W2</accession>
    <name>Q326W2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P049</name>
        <name evidence="4" type="ordered locus">SDY_P133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Sd197</strain>
            <plasmid evidence="5">Plasmid pSD1_197</plasmid>
            <plasmid evidence="4">pSD1_197</plasmid>
            <plasmid evidence="4">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406050.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406134.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64562">
        <property type="protein sequence ID" value="ABB64562"/>
        <property type="gene ID" value="SDY_P049"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64646">
        <property type="protein sequence ID" value="ABB64646"/>
        <property type="gene ID" value="SDY_P133"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P049"/>
    <dbReference type="KEGG" id="sdy:SDY_P133"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5593"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15421" checksum="B61F255B8CE09977" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIRMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-08-10" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Z4</accession>
    <name>OSPG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Protein kinase OspG</fullName>
            <ecNumber>2.7.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Effector protein OspG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ospG</name>
        <name type="ordered locus">SDY_P101</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid">
        <name>pSD1_197</name>
    </geneLocation>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is a kinase that is involved in down-regulation of the host innate response induced by invasive bacteria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <text evidence="1">Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cell.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Autophosphorylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-"/>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000705601.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406102.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Z4"/>
    <dbReference type="SMR" id="Q326Z4"/>
    <dbReference type="EnsemblBacteria" id="ABB64614">
        <property type="protein sequence ID" value="ABB64614"/>
        <property type="gene ID" value="SDY_P101"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P101"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5654"/>
    <dbReference type="HOGENOM" id="CLU_120872_0_0_6"/>
    <dbReference type="OMA" id="YTEYYSA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0614">Plasmid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000395878" description="Protein kinase OspG">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="196" mass="22570" checksum="E90908CB43BCB28A" modified="2005-12-06" version="1">MKITSTIIQTPFPFENNNSHAGIVTEPILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEMAWQESELFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLNELSIIHYDLNTGNMLYDKESESLFPIDFRNIYAEYYAATKKDKEIIDRRLQMRTNDFYSLLNRKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q327C5</accession>
    <name>Q327C5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OspC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ospC2</name>
        <name evidence="10" type="ordered locus">SDY_P070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Sd197</strain>
            <plasmid evidence="11">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-arginyl-[protein] + NAD(+) = ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:69500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:17719"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:184300"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:69501"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the OspC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000701102.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406071.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327C5"/>
    <dbReference type="EnsemblBacteria" id="ABB64583">
        <property type="protein sequence ID" value="ABB64583"/>
        <property type="gene ID" value="SDY_P070"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P070"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5619"/>
    <dbReference type="HOGENOM" id="CLU_053336_0_0_6"/>
    <dbReference type="OMA" id="TAMWHAI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010366">
        <property type="entry name" value="OspC1-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06128">
        <property type="entry name" value="Shigella_OspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="484" mass="55582" checksum="C1973AB47C897408" modified="2005-12-06" version="1">MKIPEAVNHINVQNNIDLVDGKINPNKDTKALQKNISCVTNSSSSGISEKHLDHCADTVKSFLRKSIAAQSYSKMFSQGTSFKSLNLSIEAPSGARSSFRSLEHLDKVSRHYLSEIIQKTHPLSSDERHFLSIIINSDFNFRHQSNANLSNNTLNIKSFDKIKSENIQTYKNTFSEDIEEIANHDFVFFGVEISNHQETLPLNKTHHTVDFGANAYIIDHDSPYGYMTLTDHFDNAIPPVFYHEHQSFFLDNFKEVVDEVSRYVHGNQGKTDVPIFNTKDMRLGIGLHLIDFIRKSKDQRFREFCYNKNIDPVSLDRIINFVFQPEYHIPRMLSTDNFKKIRLRDISLEDAIKASNYEEINNKVTDKKMAHQALAYSLGNAKSDMALYLLSKFNFTKQDVAEMEKMNNNMYCELYDVEYLLSEDSANYKVLEYFINNGLVDVNKRFQKANSGDTMLDNAMKSKDSKTIDFLLKNGAVSGKRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q327E0</accession>
    <name>Q327E0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OspC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ospC1</name>
        <name evidence="10" type="ordered locus">SDY_P055</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Sd197</strain>
            <plasmid evidence="11">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-arginyl-[protein] + NAD(+) = ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:69500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:17719"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:184300"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:69501"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the OspC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011379035.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406056.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327E0"/>
    <dbReference type="EnsemblBacteria" id="ABB64568">
        <property type="protein sequence ID" value="ABB64568"/>
        <property type="gene ID" value="SDY_P055"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P055"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5600"/>
    <dbReference type="HOGENOM" id="CLU_053336_0_0_6"/>
    <dbReference type="OMA" id="SIANQKE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010366">
        <property type="entry name" value="OspC1-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06128">
        <property type="entry name" value="Shigella_OspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="470" mass="54079" checksum="3F38721F5927F464" modified="2005-12-06" version="1">MNISEILNSSNTQCNIDSMDNRLHTLFPKVTSVRNAAQQTMPDEKCLKDSANIIKDFFRKTIAAQSYSRMFSQGSNFKSLNIAIDAPSDAKASFKAIEHLDRLSKHYISEIRKKLHPLSAKELNLLSLIINSDLIFRHQSNSDLSDKILNIKSFNKIQSEGICTNRNTYADDIKKIANHDFVFFGVEISSHQKKHPLNTKHHTVDFGANAYMIEHSSPYGYMTLTDHFDNVIPFAQYHEHQSFLDKFSEVNEEVSRYVHGSKGIIDVPIFNTKDMKLGLGLYLIDFIRKSEDQSFKEFCYEKNLSPVDLDRIINFVFQPEYHIPRMVSTENFKKVKIREISLEEAVTASNYEEINKQVTNKKIALQALFFSITNKKEDVALYILSNFEITKQDVISIKHELYDIEYLLSAHNSSCKVLEYFINKGLVDVNTKFKKTNSGDCMLDNAIKYENAEMIKLLLKYGATSDNKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q327E3</accession>
    <name>Q327E3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P036</name>
        <name evidence="2" type="ordered locus">SDY_P052</name>
        <name evidence="3" type="ordered locus">SDY_P202</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
            <plasmid evidence="2">pSD1_197</plasmid>
            <plasmid evidence="2">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406037.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406053.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406203.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64549">
        <property type="protein sequence ID" value="ABB64549"/>
        <property type="gene ID" value="SDY_P036"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64565">
        <property type="protein sequence ID" value="ABB64565"/>
        <property type="gene ID" value="SDY_P052"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64715">
        <property type="protein sequence ID" value="ABB64715"/>
        <property type="gene ID" value="SDY_P202"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P036"/>
    <dbReference type="KEGG" id="sdy:SDY_P052"/>
    <dbReference type="KEGG" id="sdy:SDY_P202"/>
    <dbReference type="HOGENOM" id="CLU_153781_0_0_6"/>
    <dbReference type="OMA" id="CIAVRPR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="106" mass="11485" checksum="00610F7033BAD441" modified="2005-12-06" version="1">MTGQYAVRCIAVRPRTAHAAYPAVASFFPEAVELRLRKISGSLAKDIVTAAQFTIFTLQLFQTLTFSGGEPSITAPGIPLMLANPDTQSLRRTANLWSNGTNCRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Q6</accession>
    <name>Q327Q6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the antirestriction protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000855065.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405940.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Q6"/>
    <dbReference type="STRING" id="300267.SDY_4589"/>
    <dbReference type="EnsemblBacteria" id="ABB64449">
        <property type="protein sequence ID" value="ABB64449"/>
        <property type="gene ID" value="SDY_4589"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4589"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5430"/>
    <dbReference type="HOGENOM" id="CLU_085306_1_0_6"/>
    <dbReference type="OMA" id="YAYSADH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004914">
        <property type="entry name" value="Antirestrict"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042297">
        <property type="entry name" value="Antirestriction_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03230">
        <property type="entry name" value="Antirestrict"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="157" mass="17877" checksum="9778C9457DEAF80C" modified="2005-12-06" version="1">MKTLSQNTTSSACAPETGLQQLVATIVPDEQRISFWPQHFGLIPQWVTLEPRIFGWMDRLCEDYCGGIWNLYTLNNGGAFMAPEPDDDNDETWVLFNAMNGNRAEMSQEAAGIAACLMTYSHHACRTECYAMTVHYYRLRDYALQHPECSAIMRIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Q7</accession>
    <name>Q327Q7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Q7"/>
    <dbReference type="STRING" id="300267.SDY_4588"/>
    <dbReference type="EnsemblBacteria" id="ABB64448">
        <property type="protein sequence ID" value="ABB64448"/>
        <property type="gene ID" value="SDY_4588"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4588"/>
    <dbReference type="HOGENOM" id="CLU_059317_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026325">
        <property type="entry name" value="DUF932"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06067">
        <property type="entry name" value="DUF932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="104" mass="11858" checksum="9200A338AAEAC513" modified="2005-12-06" version="1">MQSLVLPPPARQALAQAALTYRYGDEHRPVTTADILTPRRREDYGKDLWSTYQTIQENMLKGGISGRSAKGKRIHTRAIHNIDTDIKLNRALWVMAETLLESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Q8</accession>
    <name>Q327Q8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405938.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Q8"/>
    <dbReference type="STRING" id="300267.SDY_4586"/>
    <dbReference type="EnsemblBacteria" id="ABB64447">
        <property type="protein sequence ID" value="ABB64447"/>
        <property type="gene ID" value="SDY_4586"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4586"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5425"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="FGFHISM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="254" mass="29538" checksum="E229051213461ABC" modified="2005-12-06" version="1">MAHIRTLETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q327V7</accession>
    <name>Q327V7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjbO</name>
        <name evidence="2" type="ordered locus">SDY_4524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327V7"/>
    <dbReference type="STRING" id="300267.SDY_4524"/>
    <dbReference type="EnsemblBacteria" id="ABB64398">
        <property type="protein sequence ID" value="ABB64398"/>
        <property type="gene ID" value="SDY_4524"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4524"/>
    <dbReference type="HOGENOM" id="CLU_1737652_0_0_6"/>
    <dbReference type="OMA" id="DSCNACK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014318">
        <property type="entry name" value="Phageshock_PspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09583">
        <property type="entry name" value="Phageshock_PspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02975">
        <property type="entry name" value="phageshock_pspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="150" mass="17429" checksum="7F2A0B2BFFC862C0" modified="2005-12-06" version="1">MKMPIKRVQTLMCWNTRSNWWRISVNFSPKSSQIHHALRTVAGRFAVKSIDYFWHDSCNASKRFHIWESIMLELLFVIGFFVMLMVTGVSLLGIIAALVVATAIMFLGGMLALMIKLLPWLLLAIAVVWVIKAIKAPKVPKYQRYDRWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q327W4</accession>
    <name>Q327W4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405882.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327W4"/>
    <dbReference type="EnsemblBacteria" id="ABB64391">
        <property type="protein sequence ID" value="ABB64391"/>
        <property type="gene ID" value="SDY_4517"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4517"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5340"/>
    <dbReference type="HOGENOM" id="CLU_132008_0_0_6"/>
    <dbReference type="OMA" id="CMYICTL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="161" mass="18636" checksum="65D0606192864BA9" modified="2005-12-06" version="1">MNISYVNSNKTTSLPVELDTLNNKDISYAKDLFLYIETQLKIAKDFCRPGEEASSSIASTVFHAFIDLANKIRGKKDFMYICTLCCFAEEVKGDYSHYRTFLFDIGNQYKVKLIQSGKKEFSLTLEFNDTIIESQKVTGNKAKHILEDIEKFYRNKPDTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q328B6</accession>
    <name>Q328B6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ytfN</name>
        <name evidence="5" type="ordered locus">SDY_4458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000060952.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405830.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328B6"/>
    <dbReference type="STRING" id="300267.SDY_4458"/>
    <dbReference type="EnsemblBacteria" id="ABB64339">
        <property type="protein sequence ID" value="ABB64339"/>
        <property type="gene ID" value="SDY_4458"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4458"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5259"/>
    <dbReference type="HOGENOM" id="CLU_002338_0_1_6"/>
    <dbReference type="OMA" id="NTAKQWP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007452">
        <property type="entry name" value="TamB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04357">
        <property type="entry name" value="TamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1259" mass="136864" checksum="33E402ED671B29D3" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q328C5</accession>
    <name>CH10_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-10</fullName>
            <shortName evidence="1">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groES</name>
        <name evidence="1" type="synonym">groS</name>
        <name type="ordered locus">SDY_4448</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001026276.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405821.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328C5"/>
    <dbReference type="SMR" id="Q328C5"/>
    <dbReference type="STRING" id="300267.SDY_4448"/>
    <dbReference type="EnsemblBacteria" id="ABB64330">
        <property type="protein sequence ID" value="ABB64330"/>
        <property type="gene ID" value="SDY_4448"/>
    </dbReference>
    <dbReference type="GeneID" id="67414760"/>
    <dbReference type="KEGG" id="sdy:SDY_4448"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5247"/>
    <dbReference type="HOGENOM" id="CLU_132825_1_1_6"/>
    <dbReference type="OMA" id="RSINMTI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000025370" description="Co-chaperonin GroES">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <sequence length="97" mass="10387" checksum="76829E09B11217EF" modified="2005-12-06" version="1">MNIRPLHDRVIVKRKEVETKSAGGIVLTGSAAAKSTRGEVLAVGNGRILENGEVKPLDVKVGDIVIFNDGYGVKSEKIDNEEVLIMSESDILAIVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q328G9</accession>
    <name>Q328G9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor P--(R)-beta-lysine ligase</fullName>
            <shortName evidence="2">EF-P--(R)-beta-lysine ligase</shortName>
            <ecNumber evidence="2">6.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">EF-P post-translational modification enzyme A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">EF-P-lysine lysyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">epmA</name>
        <name evidence="4" type="ordered locus">SDY_4399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34'.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328G9"/>
    <dbReference type="SMR" id="Q328G9"/>
    <dbReference type="STRING" id="300267.SDY_4399"/>
    <dbReference type="EnsemblBacteria" id="ABB64286">
        <property type="protein sequence ID" value="ABB64286"/>
        <property type="gene ID" value="SDY_4399"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4399"/>
    <dbReference type="HOGENOM" id="CLU_008255_1_1_6"/>
    <dbReference type="OMA" id="EWYRPGF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016880">
        <property type="term" value="F:acid-ammonia (or amide) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071915">
        <property type="term" value="P:protein-lysine lysylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00174">
        <property type="entry name" value="EF_P_modif_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004525">
        <property type="entry name" value="EpmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00462">
        <property type="entry name" value="genX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="3">
        <location>
            <begin position="29"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="335" mass="38020" checksum="A9ECE4E62BE7BE79" modified="2005-12-06" version="1">MPLSKTGDLTMSETASWQPSASIPNLLKRAAIMAEIRRFFADRGVLEVETPCMSQATVTDIHLVPFETRFVGPGHSQGMNLWLMTSPEYHMKRLLVAGCGPVFQLCRSFRNEEMGRYHNPEFTMLEWYRPHYDMYRLMNEVDDLLQQVLDCPAAESLSYQQAFLRYLEIDPLSADKTQLREVAAKLDLSNVADTEEDRDTLLQLLFTFGVEPNIGKEKPTFVYHFPASQASLAQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRAARGLPQHPIDQNLIEALKVGMPDCSGVALGVDRLVMLALGAETLAEVIAFSVDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q328I3</accession>
    <name>Q328I3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3'(2'),5'-bisphosphate nucleotidase CysQ</fullName>
            <ecNumber evidence="7">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">3'-phosphoadenosine 5'-phosphate phosphatase</fullName>
            <shortName evidence="7">PAP phosphatase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">cysQ</name>
        <name evidence="8" type="ordered locus">SDY_4385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts adenosine-3',5'-bisphosphate (PAP) to AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the inositol monophosphatase superfamily. CysQ family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000886909.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405763.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328I3"/>
    <dbReference type="SMR" id="Q328I3"/>
    <dbReference type="STRING" id="300267.SDY_4385"/>
    <dbReference type="EnsemblBacteria" id="ABB64272">
        <property type="protein sequence ID" value="ABB64272"/>
        <property type="gene ID" value="SDY_4385"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4385"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5178"/>
    <dbReference type="HOGENOM" id="CLU_044118_3_0_6"/>
    <dbReference type="OMA" id="SADCYPR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02095">
        <property type="entry name" value="CysQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006240">
        <property type="entry name" value="CysQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01331">
        <property type="entry name" value="bisphos_cysQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="246" mass="27190" checksum="215BCD3717D02D18" modified="2005-12-06" version="1">MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDIPVLSEEDPPGWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHADAELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPGFRVSIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q328J9</accession>
    <name>RS6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsF</name>
        <name type="ordered locus">SDY_4369</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001216676.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405747.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328J9"/>
    <dbReference type="SMR" id="Q328J9"/>
    <dbReference type="STRING" id="300267.SDY_4369"/>
    <dbReference type="EnsemblBacteria" id="ABB64256">
        <property type="protein sequence ID" value="ABB64256"/>
        <property type="gene ID" value="SDY_4369"/>
    </dbReference>
    <dbReference type="GeneID" id="67414819"/>
    <dbReference type="KEGG" id="sdy:SDY_4369"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5158"/>
    <dbReference type="HOGENOM" id="CLU_113441_6_1_6"/>
    <dbReference type="OMA" id="ITEASPM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020815">
        <property type="entry name" value="Ribosomal_S6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01048">
        <property type="entry name" value="RIBOSOMAL_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000229577" description="30S ribosomal protein S6">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="131" mass="15187" checksum="01C1FD0EF4197ED2" modified="2005-12-06" version="1">MRHYEIVFMVHPDQSEQVPGMIERYTAAITGAEGKIHRLEDWGRRQLAYPINKLHKAHYVLMNVEAPQEVIDELETTFRFNDAVIRSMVMRTKHAVTEASPMVKAKDERRERRDDFANETADDAEAGDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q328L7</accession>
    <name>Q328L7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein 7.4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspA</name>
        <name evidence="4" type="ordered locus">SDY_4347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000014594.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405729.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328L7"/>
    <dbReference type="SMR" id="Q328L7"/>
    <dbReference type="STRING" id="300267.SDY_4347"/>
    <dbReference type="EnsemblBacteria" id="ABB64238">
        <property type="protein sequence ID" value="ABB64238"/>
        <property type="gene ID" value="SDY_4347"/>
    </dbReference>
    <dbReference type="GeneID" id="64293021"/>
    <dbReference type="GeneID" id="67517040"/>
    <dbReference type="KEGG" id="sdy:SDY_4347"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5131"/>
    <dbReference type="HOGENOM" id="CLU_117621_2_1_6"/>
    <dbReference type="OMA" id="GPCANKV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="70" mass="7403" checksum="CED47F00BF18A49B" modified="2005-12-06" version="1">MSGKMTGIVKWFNADKGFGFITPDDGSKDVFVHFSAIQNDGYKSLDEGQKVSFTIESGAKGPAAGNVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q329A9</accession>
    <name>Q329A9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329A9"/>
    <dbReference type="STRING" id="300267.SDY_4191"/>
    <dbReference type="EnsemblBacteria" id="ABB64096">
        <property type="protein sequence ID" value="ABB64096"/>
        <property type="gene ID" value="SDY_4191"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4191"/>
    <dbReference type="HOGENOM" id="CLU_1874029_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="143" mass="16273" checksum="7CC29A67DF77164B" modified="2005-12-06" version="1">METAEVIANHYENDKDVVRELLSLSRNNAVCSLYAASYKTMSKQVIDVYLNAAIRLALQHGFTFDEIVEQFTRDFDGKSFSHVVEKADDIYMGLWLKIFKIVVGENENYLKDVMMQLEAKNNEGKYVISKANGNPVLVMPLIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q329B4</accession>
    <name>RNPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease P protein component</fullName>
            <shortName evidence="1">RNase P protein</shortName>
            <shortName evidence="1">RNaseP protein</shortName>
            <ecNumber evidence="1">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnpA</name>
        <name type="ordered locus">SDY_4186</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000239730.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405582.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329B4"/>
    <dbReference type="SMR" id="Q329B4"/>
    <dbReference type="STRING" id="300267.SDY_4186"/>
    <dbReference type="EnsemblBacteria" id="ABB64091">
        <property type="protein sequence ID" value="ABB64091"/>
        <property type="gene ID" value="SDY_4186"/>
    </dbReference>
    <dbReference type="GeneID" id="67417694"/>
    <dbReference type="KEGG" id="sdy:SDY_4186"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4924"/>
    <dbReference type="HOGENOM" id="CLU_117179_11_0_6"/>
    <dbReference type="OMA" id="LHQHELP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000021466" description="Ribonuclease P protein component">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <sequence length="119" mass="13789" checksum="449D9EDACA1C6240" modified="2005-12-06" version="1">MVKLAFPRELRLLTPSQFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAHERNRIKRLTRESFRLRQHELPAMDFVVVAKKGVADLDNRALSEALEKLWRRHCRLARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q329J5</accession>
    <name>Q329J5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_0023</name>
        <name evidence="4" type="ordered locus">SDY_4096</name>
        <name evidence="5" type="ordered locus">SDY_4163</name>
        <name evidence="6" type="ordered locus">SDY_4331</name>
        <name evidence="7" type="ordered locus">SDY_4408</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401751.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405501.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405563.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405714.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405786.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60263">
        <property type="protein sequence ID" value="ABB60263"/>
        <property type="gene ID" value="SDY_0023"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64010">
        <property type="protein sequence ID" value="ABB64010"/>
        <property type="gene ID" value="SDY_4096"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64072">
        <property type="protein sequence ID" value="ABB64072"/>
        <property type="gene ID" value="SDY_4163"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64223">
        <property type="protein sequence ID" value="ABB64223"/>
        <property type="gene ID" value="SDY_4331"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64295">
        <property type="protein sequence ID" value="ABB64295"/>
        <property type="gene ID" value="SDY_4408"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0023"/>
    <dbReference type="KEGG" id="sdy:SDY_4096"/>
    <dbReference type="KEGG" id="sdy:SDY_4163"/>
    <dbReference type="KEGG" id="sdy:SDY_4331"/>
    <dbReference type="KEGG" id="sdy:SDY_4408"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.24"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="PLDVVIW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14896" checksum="F06568D7CE7DE1F4" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPLDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q329L0</accession>
    <name>Q329L0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yicG</name>
        <name evidence="9" type="ordered locus">SDY_4077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405486.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329L0"/>
    <dbReference type="STRING" id="300267.SDY_4077"/>
    <dbReference type="EnsemblBacteria" id="ABB63995">
        <property type="protein sequence ID" value="ABB63995"/>
        <property type="gene ID" value="SDY_4077"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4077"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4797"/>
    <dbReference type="HOGENOM" id="CLU_064906_2_0_6"/>
    <dbReference type="OMA" id="MPKFDYQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="109"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="223" mass="24358" checksum="045B156259146EE0" modified="2005-12-06" version="1">MTMRTNRYPARQIFRERTMLLHILYLVGITAEAMTGALAAGRRRMDTFGVIIIATATAIGGGSVRDILLGHYPLGWVKHPEYVIIVATAAVLTTIVAPVMPYLRKVFLVLDALGLVVFSIIGAQVALDMGHGPIIAVVAAVTTGVFGGVLRDMFCKRIPLVFQKELYAGVSFASAVLYIALQHYVSNHDVVIISTLVFGFFARLLALRLKLGLPVFYYSHEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q329M6</accession>
    <name>Q329M6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucosyltransferase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rfaG</name>
        <name evidence="3" type="ordered locus">SDY_4061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000634272.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405470.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329M6"/>
    <dbReference type="STRING" id="300267.SDY_4061"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63979">
        <property type="protein sequence ID" value="ABB63979"/>
        <property type="gene ID" value="SDY_4061"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4061"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4777"/>
    <dbReference type="HOGENOM" id="CLU_009583_44_2_6"/>
    <dbReference type="OMA" id="YRRWGRY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="183"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="374" mass="42617" checksum="33B4CC73669E30B4" modified="2005-12-06" version="1">MIVAFCLYKYFPFGGLQRDFMRIAQTVATRGHHVRVYTQSWEGECPDVFELIKVPVKSHTNHGRNAEYFAWVQKHLREHPVDKVVGFNKMPGLDVYYAADVCYAEKVAQEKGFFYRLTSRYRHYAAFERATFEQGKPTQLLMLTDKQIADFQKHYQTEAERFHILPPGIYPDRKYSQQPANSREIFRKKNGITEQQYLLLQVGSDFTRKGVDRSIEALASLPDSLRHNTLLYVVGQDKPRKFEALAEKRGVRSNVHFFSGRNDVSELMAAADLLLHPAYQEAAGIVLLEAITAGLPVLTTAVCGYAHYIVEANCGEAIVEPFRQETLNEILRKALTQSSLRQAWAENARHYADTQDLYCLPEKAADIITGGLDG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AF8</accession>
    <name>RL7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rplL</name>
        <name type="ordered locus">SDY_3742</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000028878.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405188.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AF8"/>
    <dbReference type="SMR" id="Q32AF8"/>
    <dbReference type="STRING" id="300267.SDY_3742"/>
    <dbReference type="EnsemblBacteria" id="ABB63697">
        <property type="protein sequence ID" value="ABB63697"/>
        <property type="gene ID" value="SDY_3742"/>
    </dbReference>
    <dbReference type="GeneID" id="67415313"/>
    <dbReference type="KEGG" id="sdy:SDY_3742"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4437"/>
    <dbReference type="HOGENOM" id="CLU_086499_3_2_6"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000243494" description="50S ribosomal protein L7/L12">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <sequence length="121" mass="12295" checksum="08B051A0CDAA527E" modified="2007-01-23" version="3">MSITKDQIIEAVAAMSVMDVVELISAMEEKFGVSAAAAVAVAAGPVEAAEEKTEFDVILKAAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKALEEAGAEVEVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B40</accession>
    <name>RS17_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsQ</name>
        <name type="ordered locus">SDY_3487</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000130100.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404956.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B40"/>
    <dbReference type="SMR" id="Q32B40"/>
    <dbReference type="STRING" id="300267.SDY_3487"/>
    <dbReference type="EnsemblBacteria" id="ABB63465">
        <property type="protein sequence ID" value="ABB63465"/>
        <property type="gene ID" value="SDY_3487"/>
    </dbReference>
    <dbReference type="GeneID" id="60371752"/>
    <dbReference type="GeneID" id="67415352"/>
    <dbReference type="KEGG" id="sdy:SDY_3487"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4140"/>
    <dbReference type="HOGENOM" id="CLU_073626_1_1_6"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="PRO" id="PR:Q32B40"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000233564" description="30S ribosomal protein S17">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <sequence length="84" mass="9704" checksum="FC64AF04841842F6" modified="2005-12-06" version="1">MTDKIRTLQGRVVSDKMEKSIVVAIERFVKHPIYGKFIKRTTKLHVHDENNECGIGDVVEIRECRPLSKTKSWTLVRVVEKAVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B54</accession>
    <name>RS11_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsK</name>
        <name type="ordered locus">SDY_3473</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001029684.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404942.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B54"/>
    <dbReference type="SMR" id="Q32B54"/>
    <dbReference type="STRING" id="300267.SDY_3473"/>
    <dbReference type="EnsemblBacteria" id="ABB63451">
        <property type="protein sequence ID" value="ABB63451"/>
        <property type="gene ID" value="SDY_3473"/>
    </dbReference>
    <dbReference type="GeneID" id="67415338"/>
    <dbReference type="KEGG" id="sdy:SDY_3473"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4126"/>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_6"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="PRO" id="PR:Q32B54"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000230430" description="30S ribosomal protein S11">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <sequence length="129" mass="13845" checksum="0C759DDA60E89C0C" modified="2005-12-06" version="1">MAKAPIRARKRVRKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFAAQVAAERCADAVKEYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BB7</accession>
    <name>Q32BB7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetylmannosamine kinase</fullName>
            <ecNumber evidence="1">2.7.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ManNAc kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-D-mannosamine kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhcI</name>
        <name evidence="1" type="synonym">nanK</name>
        <name evidence="2" type="ordered locus">SDY_3397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23832"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16062"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family. NanK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.60" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BB7"/>
    <dbReference type="STRING" id="300267.SDY_3397"/>
    <dbReference type="EnsemblBacteria" id="ABB63388">
        <property type="protein sequence ID" value="ABB63388"/>
        <property type="gene ID" value="SDY_3397"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3397"/>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_6"/>
    <dbReference type="OMA" id="APNIDWR"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009384">
        <property type="term" value="F:N-acylmannosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01234">
        <property type="entry name" value="ManNAc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023945">
        <property type="entry name" value="ManNAc_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="143"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="302" mass="30723" checksum="0C0B20D5973ABAA8" modified="2005-12-06" version="1">MVQHSDEKGGAMTTLAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPQALRDALSALVSPLQAHAQRVAIASTGIIRDGSLLALNPHNLGGLLHFPLVKTLEQLTNLPTIAINDAQAAAWAEYQALEGDVTEMVFITVSTGVGGGVVSGGKLLTGPGGLAGHIGHTLADPHGPVCGCGRTGCVEAIASGCGIAAAAQGELAGADAKTIFMRAGQGDEQAQQLIHRSAHVLARLIADIKATTDCQCVVVGGSVGLAEGYLALVETYLAQEPAAFHVDLLAAHYRHDAGLLGAALLAQGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BD9</accession>
    <name>Q32BD9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Intermembrane phospholipid transport system permease protein MlaE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yrbE</name>
        <name evidence="11" type="ordered locus">SDY_3375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the MlaE permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000925792.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404857.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BD9"/>
    <dbReference type="STRING" id="300267.SDY_3375"/>
    <dbReference type="EnsemblBacteria" id="ABB63366">
        <property type="protein sequence ID" value="ABB63366"/>
        <property type="gene ID" value="SDY_3375"/>
    </dbReference>
    <dbReference type="GeneID" id="67415972"/>
    <dbReference type="KEGG" id="sdy:SDY_3375"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4029"/>
    <dbReference type="HOGENOM" id="CLU_045686_1_1_6"/>
    <dbReference type="OMA" id="NYLVFPK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="260" mass="27877" checksum="27FE38790DC5A653" modified="2005-12-06" version="1">MLLNALASLGHKGIKTLRTFGRAGLMLFNALVGKPEFRKHAPLLVRQLYNVGVLSMLIIVVSGVFIGMVLGLQGYLVLTTYSAETSLGMLVALSLLRELGPVVAALLFAGRAGSALTAEIGLMRATEQLSSMEMMAVDPLRRVISPRFWAGVISLPLLTIIFVAVGIWGGSLVGVSWKGIDSGFFWSAMQNAVDWRMDLVNCLIKSVVFAITVTWISLFNGYDAIPTSAGISRATTRTVVHSSLAVLGLDFVLTALMFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BL9</accession>
    <name>Q32BL9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3288</name>
        <name evidence="3" type="ordered locus">SDY_4228</name>
        <name evidence="4" type="ordered locus">SDY_P215</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">Sd197</strain>
            <plasmid evidence="5">Plasmid pSD1_197</plasmid>
            <plasmid evidence="4">pSD1_197</plasmid>
            <plasmid evidence="4">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406216.2">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63286">
        <property type="protein sequence ID" value="ABB63286"/>
        <property type="gene ID" value="SDY_3288"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64130">
        <property type="protein sequence ID" value="ABB64130"/>
        <property type="gene ID" value="SDY_4228"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64728">
        <property type="protein sequence ID" value="ABB64728"/>
        <property type="gene ID" value="SDY_P215"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3288"/>
    <dbReference type="KEGG" id="sdy:SDY_4228"/>
    <dbReference type="KEGG" id="sdy:SDY_P215"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5769"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="PRRTMYY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32030" checksum="D1FA46CF84C2DB02" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BT0</accession>
    <name>Q32BT0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AraC_E_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000183496.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404716.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BT0"/>
    <dbReference type="STRING" id="300267.SDY_3216"/>
    <dbReference type="EnsemblBacteria" id="ABB63225">
        <property type="protein sequence ID" value="ABB63225"/>
        <property type="gene ID" value="SDY_3216"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3216"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3841"/>
    <dbReference type="HOGENOM" id="CLU_129801_0_0_6"/>
    <dbReference type="OMA" id="RTHATFN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="160" mass="17840" checksum="2F25A02CBF34EAB6" modified="2005-12-06" version="1">MTNLTLDVNIIDFPSIPVAMLPHRCSPELLNYSVAKFIMWRKETGLSPVNQSQTFGVAWDDPATTAPEAFRFDICGSVSEPIPDNRYGVSNGELTGGRYAVARHVGELDDISHTIWGIIRHWLPASGEKMRKAPILFHYTNLAEGVTEQRLETNVYVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BX9</accession>
    <name>Q32BX9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygfD</name>
        <name evidence="2" type="ordered locus">SDY_3163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BX9"/>
    <dbReference type="STRING" id="300267.SDY_3163"/>
    <dbReference type="EnsemblBacteria" id="ABB63176">
        <property type="protein sequence ID" value="ABB63176"/>
        <property type="gene ID" value="SDY_3163"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3163"/>
    <dbReference type="HOGENOM" id="CLU_043725_2_2_6"/>
    <dbReference type="OMA" id="WMWERID"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="306" mass="33948" checksum="006E3D97E04C2EF1" modified="2005-12-06" version="1">MTLVESRHPRHQALSTQLLDAIMPYCGNALRLGVTGTPGAGKSTFLEAFGMLLIRDGLKVAVIAVDPSSPVTGGSILGDKTRMNDLARAETAFIRPVPSSGHLGGACQRARELMLLCEAAGYDVVIVETVGVGQSETEVARMVDCFISLQIAGGGDDLQGIKKGLMEVADLIVINKDDGDHHTNVAIARHMYESALHILRRKYDEWQPRVLTCSALEKRGIDEIWHAIIDFKTALTASGRLQQVRQQQSVEWLRKQTEEEVLNHLFANEDFDRYYRQTLLAVKNNTLSPRTGLRQLSEFIQTQYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C20</accession>
    <name>Q32C20_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yggS</name>
        <name evidence="5" type="ordered locus">SDY_3122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000997795.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404626.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C20"/>
    <dbReference type="SMR" id="Q32C20"/>
    <dbReference type="STRING" id="300267.SDY_3122"/>
    <dbReference type="EnsemblBacteria" id="ABB63136">
        <property type="protein sequence ID" value="ABB63136"/>
        <property type="gene ID" value="SDY_3122"/>
    </dbReference>
    <dbReference type="GeneID" id="66673167"/>
    <dbReference type="KEGG" id="sdy:SDY_3122"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3731"/>
    <dbReference type="HOGENOM" id="CLU_059988_0_1_6"/>
    <dbReference type="OMA" id="IEWHMIG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="234" mass="25787" checksum="2AA431E2D75BCA59" modified="2005-12-06" version="1">MNDIAHNLAQVRDKISAAATRCGRSPEEITLLAVSKTKPASAIAEAIDAGQRQFGENYVQEGVDKIRHFQELGVTGLEWHFIGPLQSNKSRLVAEHFDWCHTIDRLRIATRLNDQRPAELPPLNVLIQINISDENSKSGIQLAELDELAAAVAELPRLRLRGLMAIPAPESEYVRQFEVARQMAVAFAGLKTRYPHIDTLSLGMSDDMEAAIAAGSTMVRIGTAIFGARDYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C98</accession>
    <name>Q32C98_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prepilin peptidase dependent protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppdC</name>
        <name evidence="3" type="ordered locus">SDY_3040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001276459.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404548.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C98"/>
    <dbReference type="STRING" id="300267.SDY_3040"/>
    <dbReference type="EnsemblBacteria" id="ABB63057">
        <property type="protein sequence ID" value="ABB63057"/>
        <property type="gene ID" value="SDY_3040"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3040"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3645"/>
    <dbReference type="HOGENOM" id="CLU_143487_1_0_6"/>
    <dbReference type="OMA" id="QYRQLWH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022204">
        <property type="entry name" value="DUF3728"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12528">
        <property type="entry name" value="T2SSppdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="107" mass="11946" checksum="D4B939EF6085704B" modified="2005-12-06" version="1">MSASLKNQQGFSLPEVMLAMVLMVMIVTALSGFQRTLMNSLASRNQYQQLWRHGWQQTQLRAISPPANWQVNRMQTSQAGCVSISVTLVSPGGRAGEMTRLHCPNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CH0</accession>
    <name>Q32CH0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1159</name>
        <name evidence="2" type="ordered locus">SDY_2959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_1159"/>
    <dbReference type="EnsemblBacteria" id="ABB61316">
        <property type="protein sequence ID" value="ABB61316"/>
        <property type="gene ID" value="SDY_1159"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62985">
        <property type="protein sequence ID" value="ABB62985"/>
        <property type="gene ID" value="SDY_2959"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1159"/>
    <dbReference type="KEGG" id="sdy:SDY_2959"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_11_6"/>
    <dbReference type="OMA" id="EFEPEHA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="116" mass="13197" checksum="AE49D33D16F62F49" modified="2005-12-06" version="1">MVTLCHVFGVHRSSYRYWKNRPEKPDGRRAVLRSQVLELHGISHGSAGARSIATMATRRGYQMGRWLAGRLMKELGLVSCQQPTHRYKRGGHEHVAIPNYLERQFAGDRAKSGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CJ7</accession>
    <name>Q32CJ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ygbA</name>
        <name evidence="1" type="ordered locus">SDY_2932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000015494.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404449.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CJ7"/>
    <dbReference type="STRING" id="300267.SDY_2932"/>
    <dbReference type="EnsemblBacteria" id="ABB62958">
        <property type="protein sequence ID" value="ABB62958"/>
        <property type="gene ID" value="SDY_2932"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2932"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3522"/>
    <dbReference type="HOGENOM" id="CLU_138593_1_0_6"/>
    <dbReference type="OMA" id="CPIHCYK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020483">
        <property type="entry name" value="Uncharacterised_YgbA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11756">
        <property type="entry name" value="YgbA_NO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="114" mass="13577" checksum="813DF11D1813A4DF" modified="2005-12-06" version="1">MSGKRISREKLTIKKMIDLYQAKCPQASAEPEHYEALFVYAQKRLDKCVFGEEKPACKQCPVHCYQPAKREEMKQIMRWAGPRMLWRHPILTVRHLIDDKRPVPELPEKYRPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CK8</accession>
    <name>Q32CK8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane-spanning protein of hydrogenase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hycD</name>
        <name evidence="6" type="ordered locus">SDY_2919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CK8"/>
    <dbReference type="STRING" id="300267.SDY_2919"/>
    <dbReference type="EnsemblBacteria" id="ABB62947">
        <property type="protein sequence ID" value="ABB62947"/>
        <property type="gene ID" value="SDY_2919"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2919"/>
    <dbReference type="HOGENOM" id="CLU_015134_2_1_6"/>
    <dbReference type="OMA" id="KIMARIQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="269" mass="28979" checksum="4482493D940E71A3" modified="2005-12-06" version="1">MLQEYRDIIKLLGRQSVGPDASGWVFRLTPYVMVGVMLTIATALPVVTVGSPLPQLGDLITLLYLFAIARFFFAISGLDTGSPFTAIGASREAMLGVLVEPMLLLGLWVAAQVAGSTNISNITDTVYHWPLSQSIPLVLALCACAFATFIEMGKLPFDLAEAEQELQEGPLSEYSGSGFGVMKWGISLKQLVVLQMFVGVFIPWGQMETFTVGGLLLALVIAIVKLVVGVLVIALFENSMARLRLDITPRITWAGFGFAFLAFVSLLAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CX5</accession>
    <name>GRPE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">grpE</name>
        <name type="ordered locus">SDY_2787</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001296310.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404321.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CX5"/>
    <dbReference type="SMR" id="Q32CX5"/>
    <dbReference type="STRING" id="300267.SDY_2787"/>
    <dbReference type="EnsemblBacteria" id="ABB62830">
        <property type="protein sequence ID" value="ABB62830"/>
        <property type="gene ID" value="SDY_2787"/>
    </dbReference>
    <dbReference type="GeneID" id="66673498"/>
    <dbReference type="KEGG" id="sdy:SDY_2787"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3358"/>
    <dbReference type="HOGENOM" id="CLU_057217_6_0_6"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_1000053640" description="Protein GrpE">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="197" mass="21812" checksum="55F2145769424BF1" modified="2005-12-06" version="1">MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CZ5</accession>
    <name>Q32CZ5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.51</ecNumber>
            <ecNumber evidence="7">5.4.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">pheA</name>
        <name evidence="24" type="ordered locus">SDY_2767</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="8"/>
    <dbReference type="EC" id="5.4.99.5" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000200092.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404301.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CZ5"/>
    <dbReference type="STRING" id="300267.SDY_2767"/>
    <dbReference type="EnsemblBacteria" id="ABB62810">
        <property type="protein sequence ID" value="ABB62810"/>
        <property type="gene ID" value="SDY_2767"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2767"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3334"/>
    <dbReference type="HOGENOM" id="CLU_035008_1_0_6"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010952">
        <property type="entry name" value="CM_P_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01797">
        <property type="entry name" value="CM_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="21">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="22">
        <location>
            <begin position="105"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="23">
        <location>
            <begin position="299"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="20">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ABB62810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="386" mass="42916" checksum="D471FB7C743349FC" modified="2005-12-06" version="1">MTSENPLLALREKISALDEKLLALLAERRELAVEVGKAKLLSHRPVRDIDRELDLLEGLITLGKAHHLDAHYITRLFQLIIEDSVLTQQALLQQHLNKINPHSARIAFLGPKGSYSHLAARQYAARHFEQFIESGCAKFADIFNQVETGQADYAVVPIENTSSGAINDVYDLLQHTSLSIVGEMTLTIDHCLLVSGTTDLSTINTVYSHPQPFQQCSKFLNRYPHWKIEYTESTSAAMEKVAQAKSPHVAALGSEAGGTLYGLQVLERIEANQRQNFTRFVVLARKAINVSDQVPAKTTLLMATGQQAGALVEALLVLRNHNLIMTCLESRPIHGNPWEEMFYLDIQANLESAEMQKALKELGEITRSMKVLGCYPSENVVPVDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D02</accession>
    <name>Q32D02_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D02"/>
    <dbReference type="EnsemblBacteria" id="ABB62803">
        <property type="protein sequence ID" value="ABB62803"/>
        <property type="gene ID" value="SDY_2760"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2760"/>
    <dbReference type="HOGENOM" id="CLU_131537_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13194" checksum="EC4A278FA79DCBB4" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITSHAMPALSKFRILPLTDGLPRRVTGFTAMMNLFLTTGSKRKMSVMPFWLRSVPGQGNGKKTCCWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D31</accession>
    <name>Q32D31_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="7">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">suhB</name>
        <name evidence="8" type="ordered locus">SDY_2729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000553453.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404265.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D31"/>
    <dbReference type="STRING" id="300267.SDY_2729"/>
    <dbReference type="EnsemblBacteria" id="ABB62774">
        <property type="protein sequence ID" value="ABB62774"/>
        <property type="gene ID" value="SDY_2729"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2729"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3291"/>
    <dbReference type="HOGENOM" id="CLU_044118_0_4_6"/>
    <dbReference type="OMA" id="RVDGYWE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="267" mass="29187" checksum="5778F9D2BD110577" modified="2005-12-06" version="1">MHPMLNIAVRAARKAGNLIAKNYETPDAVEASQKGSNDFVTNVDKAAEAVIIDTIRKSYPQHTIITEESGELEGTDQDVQWVIDPLDGTTNFIKRLPHFAVSIAVRIKGRTEVAVVYDPMRNELFTATRGQGAQLNGYRLRGSTARDLDGTILATGFPFKAKQYATTYINIVGKLFNECADFRRTGSAALDLAYVASGRVDGFFEIGLRPWDFAAGELLVREAGGIVSNFTGGHNYMLTGNIVAGNPRVVKAMLANMRDELSDALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D99</accession>
    <name>Q32D99_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yffB</name>
        <name evidence="3" type="ordered locus">SDY_2655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000258247.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404197.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D99"/>
    <dbReference type="STRING" id="300267.SDY_2655"/>
    <dbReference type="EnsemblBacteria" id="ABB62706">
        <property type="protein sequence ID" value="ABB62706"/>
        <property type="gene ID" value="SDY_2655"/>
    </dbReference>
    <dbReference type="GeneID" id="66673667"/>
    <dbReference type="KEGG" id="sdy:SDY_2655"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3204"/>
    <dbReference type="HOGENOM" id="CLU_116644_2_1_6"/>
    <dbReference type="OMA" id="FGIKNCD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="118" mass="13514" checksum="38DF106D97A5D9EA" modified="2005-12-06" version="1">MVTLYGIKNCDTIKKARRWLEANNIDYRFHDYRVDGLDSELLNGFINELGWEALLNTRGTTWRKLDETTRNKITDAASAAALMTEMPAIIKRPLLCAPGKPMLLGFSDSSYQQFFHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DB8</accession>
    <name>Q32DB8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">amiA</name>
        <name evidence="6" type="ordered locus">SDY_2633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.</text>
            <dbReference type="EC" id="3.5.1.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000102893.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404178.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DB8"/>
    <dbReference type="STRING" id="300267.SDY_2633"/>
    <dbReference type="EnsemblBacteria" id="ABB62687">
        <property type="protein sequence ID" value="ABB62687"/>
        <property type="gene ID" value="SDY_2633"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2633"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3171"/>
    <dbReference type="HOGENOM" id="CLU_014322_4_1_6"/>
    <dbReference type="OMA" id="QIRPVHH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220909" description="N-acetylmuramoyl-L-alanine amidase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="5">
        <location>
            <begin position="118"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="289" mass="31426" checksum="0D4D1E5501839FC9" modified="2005-12-06" version="1">MSTFKPLKTLTSRRQVLKAGLAALTLSGMSQAIAKDEPLKTSNGHSKPKAKKSGGKRVVVLDPGHGGIDTGAIGRNGSKEKHVVLAIAKNVRSILRNHGIDARLTRSGDTFIPLYDRVEIAHKHGADLFMSIHADGFTNPKAAGASVFALSNRGASSAMAKYLSERENRADEVAGKKATDKDHLLQQVLFDLVQTDTIKNSLTLGSHILKKIKPVHKLHSRNTEQAAFVVLKSPSVPSVLVETSFITNPEEERLLGTAAFRQKIATAIAEGVISYFHWFDNQKTHSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DE8</accession>
    <name>Q32DE8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative virulence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SDY_2598</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000826379.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404148.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DE8"/>
    <dbReference type="STRING" id="300267.SDY_2598"/>
    <dbReference type="EnsemblBacteria" id="ABB62657">
        <property type="protein sequence ID" value="ABB62657"/>
        <property type="gene ID" value="SDY_2598"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2598"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3135"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_4_6"/>
    <dbReference type="OMA" id="WYEMHRQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="162"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="304"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB62657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="402" mass="45676" checksum="44ACB54E77AD264B" modified="2005-12-06" version="1">MKRLQAFKFQLRPAGQQEREMRRFAGACRFVFNRALARQNENHEAGNKYIPYGKMASWLVEWKNATETQWLKDSPSQPLQQSLKDLERAYKNFFRKRAAFPRFKKRGQNDAFRYPQGVKLDQENSRIFLPKLGWMRYRNSRQVTGVVKNVTVSQSCGKWYISIQTESEVSTPVHPPASMVGLDAGVAKLATLSDGTVFEPVNSFQKNQKKLARLQRQLSRKVKFSNNWQKQKRKIQRLHSCTANIRRDYLHKVTTTVSKNHAMIVIEDLKVSNMSTSAAGTVSQPGRNVRAKSGLNRSILDQGWYEMRRQLAYKQLWRGGQVLAVPPAYTSQRCACCGHTAKENRLSQSKFRCQVCGYTANADVNGARNILAAGHAVLACGGMVQSGRPLKQEPTEMIQATA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DF6</accession>
    <name>MNTH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Divalent metal cation transporter MntH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mntH</name>
        <name type="ordered locus">SDY_2588</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">H(+)-stimulated, divalent metal cation uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NRAMP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000186379.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404140.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DF6"/>
    <dbReference type="SMR" id="Q32DF6"/>
    <dbReference type="STRING" id="300267.SDY_2588"/>
    <dbReference type="EnsemblBacteria" id="ABB62649">
        <property type="protein sequence ID" value="ABB62649"/>
        <property type="gene ID" value="SDY_2588"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2588"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3123"/>
    <dbReference type="HOGENOM" id="CLU_020088_2_0_6"/>
    <dbReference type="OMA" id="IATFVNS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0769">Symport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000024109" description="Divalent metal cation transporter MntH">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="119"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="345"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="407"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00221"/>
        </source>
    </evidence>
    <sequence length="412" mass="44208" checksum="393847BFE6A51CA9" modified="2005-12-06" version="1">MTNYRVESSSGRAARKMRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLTLMLQRRGQKPLEKVIGGLLLFVAAAYIVELIFSQPNLAQLGKGMVIPSLPTSEAVFLAAGVLGATIMPHVIYLHSSLTQHLYGGSRQQRYSATKWDVAIAMTIAGFVNLAMMATAAAAFHFSGHTGVADLDEAYLTLQPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFIRFHIPLWVRRTVTMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSDSKLMGDLVNSKRVKQTGWVIVVLVVALNIWLLVGTALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DM8</accession>
    <name>Q32DM8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histidine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisQ</name>
        <name evidence="9" type="ordered locus">SDY_2507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000965518.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404068.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DM8"/>
    <dbReference type="SMR" id="Q32DM8"/>
    <dbReference type="STRING" id="300267.SDY_2507"/>
    <dbReference type="EnsemblBacteria" id="ABB62577">
        <property type="protein sequence ID" value="ABB62577"/>
        <property type="gene ID" value="SDY_2507"/>
    </dbReference>
    <dbReference type="GeneID" id="67416738"/>
    <dbReference type="KEGG" id="sdy:SDY_2507"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3022"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_4_6"/>
    <dbReference type="OMA" id="IWTFVWI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030199">
        <property type="entry name" value="HisQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30133:SF1">
        <property type="entry name" value="PTHR30133:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="13"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="228" mass="24633" checksum="603795BF93FA7033" modified="2005-12-06" version="1">MLYGFSGVILQGALVTLELAISSVVLAVIIGLIGAGGKLSQNRLSGLIFEGYTTLIRGVPDLVLMLLIFYGLQIALNTVTEAMGVGQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKSTALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLFLERRYSVGVKRADL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DQ3</accession>
    <name>NUOCD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit C/D</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit C/D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit C/D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoC</name>
        <name evidence="1" type="synonym">nuoCD</name>
        <name evidence="1" type="synonym">nuoD</name>
        <name type="ordered locus">SDY_2482</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000247878.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404043.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DQ3"/>
    <dbReference type="SMR" id="Q32DQ3"/>
    <dbReference type="STRING" id="300267.SDY_2482"/>
    <dbReference type="EnsemblBacteria" id="ABB62552">
        <property type="protein sequence ID" value="ABB62552"/>
        <property type="gene ID" value="SDY_2482"/>
    </dbReference>
    <dbReference type="GeneID" id="67416716"/>
    <dbReference type="KEGG" id="sdy:SDY_2482"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2993"/>
    <dbReference type="HOGENOM" id="CLU_015134_3_2_6"/>
    <dbReference type="OMA" id="GGRMHYM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01359">
        <property type="entry name" value="NDH1_NuoCD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023062">
        <property type="entry name" value="NADH_DH_suCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000358697" description="NADH-quinone oxidoreductase subunit C/D">
        <location>
            <begin position="1"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADH dehydrogenase I subunit C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADH dehydrogenase I subunit D" evidence="1">
        <location>
            <begin position="214"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01359"/>
        </source>
    </evidence>
    <sequence length="600" mass="68725" checksum="F83080352BB43A0A" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DV3</accession>
    <name>Q32DV3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nrdB</name>
        <name evidence="5" type="ordered locus">SDY_2429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000332037.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403993.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DV3"/>
    <dbReference type="SMR" id="Q32DV3"/>
    <dbReference type="STRING" id="300267.SDY_2429"/>
    <dbReference type="EnsemblBacteria" id="ABB62502">
        <property type="protein sequence ID" value="ABB62502"/>
        <property type="gene ID" value="SDY_2429"/>
    </dbReference>
    <dbReference type="GeneID" id="60904070"/>
    <dbReference type="KEGG" id="sdy:SDY_2429"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2927"/>
    <dbReference type="HOGENOM" id="CLU_062403_0_0_6"/>
    <dbReference type="OMA" id="KVGEYQR"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="376" mass="43517" checksum="BF2D9A49B643E84A" modified="2005-12-06" version="1">MAYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSNFQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DY4</accession>
    <name>YBJQ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0145 protein YbjQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybjQ</name>
        <name type="ordered locus">SDY_2397</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001160737.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403962.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DY4"/>
    <dbReference type="SMR" id="Q32DY4"/>
    <dbReference type="STRING" id="300267.SDY_2397"/>
    <dbReference type="EnsemblBacteria" id="ABB62471">
        <property type="protein sequence ID" value="ABB62471"/>
        <property type="gene ID" value="SDY_2397"/>
    </dbReference>
    <dbReference type="GeneID" id="67413908"/>
    <dbReference type="KEGG" id="sdy:SDY_2397"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2890"/>
    <dbReference type="HOGENOM" id="CLU_117144_3_0_6"/>
    <dbReference type="OMA" id="VDFEISM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000225845" description="UPF0145 protein YbjQ">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <sequence length="107" mass="11437" checksum="23C02AD23D0E4429" modified="2005-12-06" version="1">MQFSTTPTLEGQTIVEYCGVVTGEAILGANIFRDFFAGIRDIVGGRSGAYEKELRKAREIAFEELGSQARALGADAVVGIDIDYETVGQNGSMLMVSVSGTAVKTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E31</accession>
    <name>Q32E31_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">30S ribosomal protein S1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsA</name>
        <name evidence="6" type="ordered locus">SDY_2347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000140321.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403915.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E31"/>
    <dbReference type="STRING" id="300267.SDY_2347"/>
    <dbReference type="EnsemblBacteria" id="ABB62424">
        <property type="protein sequence ID" value="ABB62424"/>
        <property type="gene ID" value="SDY_2347"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2347"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2831"/>
    <dbReference type="HOGENOM" id="CLU_015805_2_1_6"/>
    <dbReference type="OMA" id="SLNEFRY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000110">
        <property type="entry name" value="Ribosomal_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002111">
        <property type="entry name" value="RpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00717">
        <property type="entry name" value="rpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="105"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="192"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="277"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="364"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="451"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="557" mass="61131" checksum="4BE4A4FF09847E18" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E80</accession>
    <name>Q32E80_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403866.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E80"/>
    <dbReference type="EnsemblBacteria" id="ABB62375">
        <property type="protein sequence ID" value="ABB62375"/>
        <property type="gene ID" value="SDY_2298"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2298"/>
    <dbReference type="HOGENOM" id="CLU_3389198_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="32" mass="3831" checksum="58BDC61D0BCD8FFE" modified="2005-12-06" version="1">MEQSTSSSNTPDIELIFRLLYLQKRRISYPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EB1</accession>
    <name>Q32EB1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactitol-specific enzyme IIB of phosphotransferase system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gatB</name>
        <name evidence="3" type="ordered locus">SDY_2265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021741.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403835.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EB1"/>
    <dbReference type="STRING" id="300267.SDY_2265"/>
    <dbReference type="EnsemblBacteria" id="ABB62344">
        <property type="protein sequence ID" value="ABB62344"/>
        <property type="gene ID" value="SDY_2265"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2265"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2735"/>
    <dbReference type="HOGENOM" id="CLU_159248_3_3_6"/>
    <dbReference type="OMA" id="AHLICTT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS_IIB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9337" checksum="7674982B62465C87" modified="2005-12-06" version="1">MKRKIIVACGGAVATSTMAAEEIKELCQSHNIPVELIQCRVNEIETYMDGVHLICTTAKVDRSFGDIPLVHGMPFVSGVGIEAYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ED3</accession>
    <name>Q32ED3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403813.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ED3"/>
    <dbReference type="EnsemblBacteria" id="ABB62322">
        <property type="protein sequence ID" value="ABB62322"/>
        <property type="gene ID" value="SDY_2239"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2239"/>
    <dbReference type="HOGENOM" id="CLU_2131843_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="113" mass="12119" checksum="A07E54E7F08F3D0E" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITQHFTKDICSMLAKSALVTTPMTGRFIDEVKLGEKGDHGASALSTSAIMSASQALTNSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EF7</accession>
    <name>Q32EF7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ugd</name>
        <name evidence="12" type="ordered locus">SDY_2213</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000704836.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403789.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EF7"/>
    <dbReference type="STRING" id="300267.SDY_2213"/>
    <dbReference type="EnsemblBacteria" id="ABB62298">
        <property type="protein sequence ID" value="ABB62298"/>
        <property type="gene ID" value="SDY_2213"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2213"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2677"/>
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        <property type="reaction ID" value="UER00491"/>
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    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:polysaccharide biosynthetic process"/>
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        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
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        <property type="entry name" value="6PGD_dom2"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="UDP-Glc/GDP-Man"/>
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    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
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    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
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    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="300"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="242"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="83"/>
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            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="145"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="306"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="307"/>
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        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="388" mass="43695" checksum="9AB1311E8FEE164F" modified="2005-12-06" version="1">MKITISGTGYVGLSNGLLIAQNHEVAALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIKDVVEINPYVVMVIKSTVPVGFTEAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGERSERAERFAALLQEGAIKQNIPPLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EN8</accession>
    <name>GCH1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="2">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP cyclohydrolase I</fullName>
            <shortName evidence="2">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folE</name>
        <name type="ordered locus">SDY_2127</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Toroid-shaped homodecamer, composed of two pentamers of five dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001139613.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403708.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EN8"/>
    <dbReference type="SMR" id="Q32EN8"/>
    <dbReference type="STRING" id="300267.SDY_2127"/>
    <dbReference type="EnsemblBacteria" id="ABB62217">
        <property type="protein sequence ID" value="ABB62217"/>
        <property type="gene ID" value="SDY_2127"/>
    </dbReference>
    <dbReference type="GeneID" id="67414563"/>
    <dbReference type="KEGG" id="sdy:SDY_2127"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2564"/>
    <dbReference type="HOGENOM" id="CLU_049768_3_2_6"/>
    <dbReference type="OMA" id="CEHMCMS"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000043739" description="GTP cyclohydrolase 1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <sequence length="222" mass="24831" checksum="23C6A1440F579FC2" modified="2005-12-06" version="1">MPSLSKEAALVHEALVARGLETPLRPPVHEMDNETRKSLIAGHMTEIMQLLNLDLADDSLMETPHRIAKMYVDEIFSGLDYANFPKITLIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILIALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRHEFLRAVRHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EX2</accession>
    <name>Q32EX2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1471 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ycfR</name>
        <name evidence="4" type="ordered locus">SDY_2038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000800153.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403624.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EX2"/>
    <dbReference type="SMR" id="Q32EX2"/>
    <dbReference type="STRING" id="300267.SDY_2038"/>
    <dbReference type="EnsemblBacteria" id="ABB62133">
        <property type="protein sequence ID" value="ABB62133"/>
        <property type="gene ID" value="SDY_2038"/>
    </dbReference>
    <dbReference type="GeneID" id="66670622"/>
    <dbReference type="KEGG" id="sdy:SDY_2038"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2452"/>
    <dbReference type="HOGENOM" id="CLU_158602_2_3_6"/>
    <dbReference type="OMA" id="IQYPQGQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036275">
        <property type="entry name" value="YdgH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010854">
        <property type="entry name" value="YdgH/BhsA/McbA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07338">
        <property type="entry name" value="DUF1471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159871">
        <property type="entry name" value="SSF159871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221083" description="DUF1471 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1471" evidence="3">
        <location>
            <begin position="34"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="85" mass="8815" checksum="BB5122FE73E72181" modified="2005-12-06" version="1">MKNVKTLIAAAILSSMSFASFAAVEVQSTPEGQQKVGTISANAGTNLGSLEEQLAQKADEMGAKSFRITSVTGPNTLHGTAVIYK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EZ2</accession>
    <name>NUDJ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Phosphatase NudJ</fullName>
            <ecNumber>3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nudJ</name>
        <name type="ordered locus">SDY_2018</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudJ subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000476093.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403604.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EZ2"/>
    <dbReference type="SMR" id="Q32EZ2"/>
    <dbReference type="STRING" id="300267.SDY_2018"/>
    <dbReference type="EnsemblBacteria" id="ABB62113">
        <property type="protein sequence ID" value="ABB62113"/>
        <property type="gene ID" value="SDY_2018"/>
    </dbReference>
    <dbReference type="GeneID" id="66670599"/>
    <dbReference type="KEGG" id="sdy:SDY_2018"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2431"/>
    <dbReference type="HOGENOM" id="CLU_037162_6_1_6"/>
    <dbReference type="OMA" id="QPAGHLD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004787">
        <property type="term" value="F:thiamine-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03675">
        <property type="entry name" value="Nudix_Hydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033713">
        <property type="entry name" value="NudJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342646" description="Phosphatase NudJ">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nudix box">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="153" mass="17433" checksum="BDB7423E97D6735A" modified="2005-12-06" version="1">MFKPHVTVACVVHAEGKFLVVEETINGKALWNQPAGHLEADETLVEAAARELWEETGISAQPQHFIRMHQWIAPDKTPFLRFLFAIELEQICPTQPHDSDIDCCRWVSAEEILQASNLRSPLVAESIRCYQSGQRYPLEMIGDFNWPFTKGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F60</accession>
    <name>Q32F60_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pspA</name>
        <name evidence="3" type="ordered locus">SDY_1940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000511015.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403536.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F60"/>
    <dbReference type="SMR" id="Q32F60"/>
    <dbReference type="STRING" id="300267.SDY_1940"/>
    <dbReference type="EnsemblBacteria" id="ABB62045">
        <property type="protein sequence ID" value="ABB62045"/>
        <property type="gene ID" value="SDY_1940"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1940"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2339"/>
    <dbReference type="HOGENOM" id="CLU_056466_3_0_6"/>
    <dbReference type="OMA" id="MIFRAKA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014319">
        <property type="entry name" value="Phageshock_PspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02977">
        <property type="entry name" value="phageshock_pspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="47"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="222" mass="25521" checksum="8666093079BDAB20" modified="2005-12-06" version="1">MGIFSRFADIVNANINALLEKAEDPQKLVRLMIQEMEDTLVEVRSTSARALAEKKQLTRRIEQASAREIEWQEKAELALLKDREDLARAALIEKQKLTDLIKSLEHEVTLVDDTLVRMKKEIGELENKLSETRARQQALMLRHQAANSSRDVRRQLDSGKLDEAMARFESFERRIDQMEAEAESHSFGKQKSLDDQFAELKADDAISEQLAQLKAKMKQDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F76</accession>
    <name>Q32F76_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403520.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F76"/>
    <dbReference type="EnsemblBacteria" id="ABB62029">
        <property type="protein sequence ID" value="ABB62029"/>
        <property type="gene ID" value="SDY_1923"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1923"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2318"/>
    <dbReference type="HOGENOM" id="CLU_162553_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="123" mass="13471" checksum="DC8DBC527994270A" modified="2005-12-06" version="1">MVVSLLGNQFYTGKDKVTFDYVLAAKLRDAGLAIERNYLVDMGNGKRGFVDIVAVAPSGERCAIEVDRASPRARSILKLRRLKLYGIPGIVLLRCSRNPEQYVSDEIDVIPATGKPRSKGASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FB2</accession>
    <name>Q32FB2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator LYSR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ydhB</name>
        <name evidence="3" type="ordered locus">SDY_1885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000269493.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403484.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FB2"/>
    <dbReference type="SMR" id="Q32FB2"/>
    <dbReference type="STRING" id="300267.SDY_1885"/>
    <dbReference type="EnsemblBacteria" id="ABB61993">
        <property type="protein sequence ID" value="ABB61993"/>
        <property type="gene ID" value="SDY_1885"/>
    </dbReference>
    <dbReference type="GeneID" id="58390396"/>
    <dbReference type="KEGG" id="sdy:SDY_1885"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2268"/>
    <dbReference type="HOGENOM" id="CLU_039613_35_1_6"/>
    <dbReference type="OMA" id="PKRTTWL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="310" mass="35264" checksum="AF6C42E908B794A0" modified="2005-12-06" version="1">MWSEYSLEVVDAVARNGSFSAAAQELHRVPSAVSYTVRQLEEWLAVPLFERRHRDVELTAAGAWFLKEGRSVVKKMQITRQQCQQIANGWRGQLAIAVDNIVRPERTRQMIVDFYRHFDDVELLVFQEVFNGVWDALSDGRVELAIGATRAIPVGGRYAFRDMGMLSWSCVVASHHPLALMDGPFSDDTLRNWPSLVREDTSRTLPKRITWLLDNQKRLVVPDWESSATCISAGLCIGMVPTHFAKPWLNEGKWVALELENPFPDSACCLTWQQNDMSPALTWLLEYLGDSETLNKEWLREPEETPATGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FF9</accession>
    <name>Q32FF9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Repressor for uid operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uidR</name>
        <name evidence="3" type="ordered locus">SDY_1837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000969092.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403437.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FF9"/>
    <dbReference type="SMR" id="Q32FF9"/>
    <dbReference type="STRING" id="300267.SDY_1837"/>
    <dbReference type="EnsemblBacteria" id="ABB61946">
        <property type="protein sequence ID" value="ABB61946"/>
        <property type="gene ID" value="SDY_1837"/>
    </dbReference>
    <dbReference type="GeneID" id="58389290"/>
    <dbReference type="KEGG" id="sdy:SDY_1837"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2215"/>
    <dbReference type="HOGENOM" id="CLU_069356_15_12_6"/>
    <dbReference type="OMA" id="AINHYFS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="196" mass="21799" checksum="22912EF7695268D4" modified="2005-12-06" version="1">MMDNMQTEAQPTRTRILNAAREIFSENGFHSASMKAICKSCAISPGTLYHHFISKEALIQAIILQDQERALARFREPIEGIHFVDYMVESIVSLTHEAFGQRALVVEIMAEGMRNPQVAAMLKNKHMTITEFVAQRMRDAQQKGEISPDINTAMTSRLLLDLTYGVLADIEAEDLAREASFAQGLRAMIGGILTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FG2</accession>
    <name>Q32FG2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FG2"/>
    <dbReference type="EnsemblBacteria" id="ABB61943">
        <property type="protein sequence ID" value="ABB61943"/>
        <property type="gene ID" value="SDY_1833"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1833"/>
    <dbReference type="HOGENOM" id="CLU_2261920_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="103" mass="11461" checksum="76A5677D41A65E8D" modified="2005-12-06" version="1">MPVVPGRFHRYGDQKCRPVPPLFWCYTRTRASVAGLTGLISVSELKNAVAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FH0</accession>
    <name>Q32FH0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rstA</name>
        <name evidence="6" type="ordered locus">SDY_1824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403426.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FH0"/>
    <dbReference type="STRING" id="300267.SDY_1824"/>
    <dbReference type="EnsemblBacteria" id="ABB61935">
        <property type="protein sequence ID" value="ABB61935"/>
        <property type="gene ID" value="SDY_1824"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1824"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2197"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_6"/>
    <dbReference type="OMA" id="QIISEVW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="238" mass="26623" checksum="8C33DDC605983C72" modified="2005-12-06" version="1">MNVMNTIVFVEDDAEVGSLIAAYLAKHDMQVTVEPRGDQAEETILRENPDLVLLDIMLPGKDGMTICRDLRAKWSGPIVLLTSLDSDMNHILALEMGACDYMPPAVLLARLRLHLRQNEQATLTKGLQETSLTPYKALHFGTLTIDPINRVVTLANTEISLSTADFELLWELATHAGQIMDRDALLKNLRGVSYDGLDRSVDVAISRLRKKLLDNAAEPYRIKTVRNKGYLFAPHAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FK0</accession>
    <name>Q32FK0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="10">PEP synthase</shortName>
            <ecNumber evidence="6 10">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ppsA</name>
        <name evidence="14" type="ordered locus">SDY_1794</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="6 10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000069392.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403396.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FK0"/>
    <dbReference type="STRING" id="300267.SDY_1794"/>
    <dbReference type="EnsemblBacteria" id="ABB61905">
        <property type="protein sequence ID" value="ABB61905"/>
        <property type="gene ID" value="SDY_1794"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1794"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2166"/>
    <dbReference type="HOGENOM" id="CLU_007308_6_2_6"/>
    <dbReference type="OMA" id="RRFVQMY"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="22"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="386"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="481"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB61905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="792" mass="87460" checksum="535A1C3F039C1C68" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FN6</accession>
    <name>Q32FN6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydcH</name>
        <name evidence="2" type="ordered locus">SDY_1752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403360.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FN6"/>
    <dbReference type="STRING" id="300267.SDY_1752"/>
    <dbReference type="EnsemblBacteria" id="ABB61869">
        <property type="protein sequence ID" value="ABB61869"/>
        <property type="gene ID" value="SDY_1752"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1752"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2112"/>
    <dbReference type="HOGENOM" id="CLU_165482_2_2_6"/>
    <dbReference type="OMA" id="MFHEYRD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007420">
        <property type="entry name" value="DUF465"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038444">
        <property type="entry name" value="DUF465_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04325">
        <property type="entry name" value="DUF465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="55" mass="6470" checksum="AC256234653E1CC5" modified="2005-12-06" version="1">MSLFDKHNKLDHEIARKEGSDGRGYNAEVVRMKKQKLQLKDEMLKILQQESVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FP5</accession>
    <name>Q32FP5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FP5"/>
    <dbReference type="EnsemblBacteria" id="ABB61860">
        <property type="protein sequence ID" value="ABB61860"/>
        <property type="gene ID" value="SDY_1743"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1743"/>
    <dbReference type="HOGENOM" id="CLU_2702782_0_0_6"/>
    <dbReference type="OMA" id="FNIFESH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="73" mass="8480" checksum="01AD6CD0DB5B150D" modified="2005-12-06" version="1">MARLELLFVNVKHGGIGRHVINNLFNIFESHWRTFVIQVFTFALTNDFDNRFISRCINQLTFKIEASIHGTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FS9</accession>
    <name>Q32FS9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carnitine monooxygenase oxygenase subunit</fullName>
            <ecNumber evidence="7">1.14.13.239</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Carnitine monooxygenase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yeaW</name>
        <name evidence="9" type="ordered locus">SDY_1706</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts carnitine to trimethylamine and malic semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine</text>
            <dbReference type="Rhea" id="RHEA:55396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="ChEBI" id="CHEBI:138809"/>
            <dbReference type="EC" id="1.14.13.239"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine</text>
            <dbReference type="Rhea" id="RHEA:55368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="ChEBI" id="CHEBI:138809"/>
            <dbReference type="EC" id="1.14.13.239"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="7">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amine and polyamine metabolism; carnitine metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Composed of an oxygenase subunit and a reductase subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.239" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000067841.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403317.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FS9"/>
    <dbReference type="STRING" id="300267.SDY_1706"/>
    <dbReference type="EnsemblBacteria" id="ABB61826">
        <property type="protein sequence ID" value="ABB61826"/>
        <property type="gene ID" value="SDY_1706"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1706"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2060"/>
    <dbReference type="HOGENOM" id="CLU_026244_3_0_6"/>
    <dbReference type="OMA" id="NIMVEWY"/>
    <dbReference type="UniPathway" id="UPA00117"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02097">
        <property type="entry name" value="Carnitine_monoox_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039004">
        <property type="entry name" value="Carnitine_monoox_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="47"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="374" mass="42590" checksum="1ED934E6E5230548" modified="2005-12-06" version="1">MSNLSPDFVLPKNFCANPQEAWTIPARFYTDQNAFEHEKENVFAKSWICVAHSSELANANDYVTREIIGESIVLVRGRDKVLRAFYNVCPHRGHQLLSGEGKAKNVITCPYHAWAFKLDGNLAHARNCENVANFDSDKAQLVPVRLEEYAGFVFINMDPNATSVEDQLPGLGAKVLEACPEVHDLKLAARFTTRMPANWKNIVDNYLECYHCGPAHPGFSDSVQVDRYWHTMHGNWTLQYGFAKPSEQSFKFEEGTDAAFHGFWLWPCTMLNVTPIKGMMTVIYEFPVDSETTLQNYDIYFTNEELTDEQKSLIEWYRDVFRPEDLRLVESVQKGLKSRGYRGQGRIMADSSGSGISEHGIAHFHNLLAQVFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G18</accession>
    <name>Q32G18_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-binding component of a transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_1611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001285518.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403228.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G18"/>
    <dbReference type="STRING" id="300267.SDY_1611"/>
    <dbReference type="EnsemblBacteria" id="ABB61737">
        <property type="protein sequence ID" value="ABB61737"/>
        <property type="gene ID" value="SDY_1611"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1611"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1937"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_6"/>
    <dbReference type="OMA" id="RCHLYRP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="308" mass="34477" checksum="F50F8F3B0070640B" modified="2005-12-06" version="1">MSDTLLTLRDVHINFPARKNWLGKTTEHVHAINGIDLQIRCGETLGIVGESGCGKSTLAQLLMGMLQPSHEQYIRSGSQRIMQMVFQDPLSSLNPRLPVWRIITEPLWIAKHSSEQQRRALAEELAVQVGIRPEYLDCLPHAFSGGQRQRIAIARALSSQPDVIVLDEPTSALDISVQAQSLNLLVTLQVNHGLTYVLISHNVSVIRHMSDRVAVMYLGQIVELGGAQQVLTAPAHPYTRLLLDSLPAIDKPLEEEWALRKTDLPGNRTLPQGCFFRERCPLATHGCEVRQSLTIREDGREIRCWRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G51</accession>
    <name>Q32G51_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0257 lipoprotein YnfC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">ynfC</name>
        <name evidence="2" type="ordered locus">SDY_1571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0257 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G51"/>
    <dbReference type="STRING" id="300267.SDY_1571"/>
    <dbReference type="EnsemblBacteria" id="ABB61704">
        <property type="protein sequence ID" value="ABB61704"/>
        <property type="gene ID" value="SDY_1571"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1571"/>
    <dbReference type="HOGENOM" id="CLU_1174761_0_0_6"/>
    <dbReference type="OMA" id="ANYYLDA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01065">
        <property type="entry name" value="UPF0257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010646">
        <property type="entry name" value="UPF0257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06788">
        <property type="entry name" value="UPF0257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="248" mass="27873" checksum="3D3FDC8DB3D9FA24" modified="2005-12-06" version="1">MIENHLYSLVTDVKYKLLPCLLAILLTGCDRTEVTLSFTPEMASFSNEFDFDPLRGPVKDFTQTLMDEQGEVTKRVSGTLSEEGCFDSLELLDLENNTVVALVLDANYYRDAETLEKRVRLQGKCQLAELPSAGVSWETDDNGFVIKASSKQMQMEYRYDDQGYPLGKTTKSNDKTLSVSATPSTDPIKKLDYTAVTLLNNQRVGNVKQSCEYDSHANPVDCQLIIVDEGVKPSVERVYTIKNTIDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GC9</accession>
    <name>Q32GC9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yeaD</name>
        <name evidence="5" type="ordered locus">SDY_1487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403117.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GC9"/>
    <dbReference type="STRING" id="300267.SDY_1487"/>
    <dbReference type="EnsemblBacteria" id="ABB61626">
        <property type="protein sequence ID" value="ABB61626"/>
        <property type="gene ID" value="SDY_1487"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1487"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1775"/>
    <dbReference type="HOGENOM" id="CLU_048345_4_1_6"/>
    <dbReference type="OMA" id="TQALHSY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="301" mass="33606" checksum="CE72C8BD5448C0AC" modified="2005-12-06" version="1">MKLKDCVMIKKIFALPVIEQISPVLSRRKLDELDLIVVDHPQVKASFALQGAHLLSWKPAGEEEVLWLSNNTPFKNGVAIRGGVPVCWPWFGPAAQRGLPAHGFARNLPWTLKSHREDANGVALTFELTQSEETKKFWPHDFTLLAHFRVCKTCEIDLEAHGEFETTSALHTYFNVGDIAKVSVSGLGNRFIDKVNDAKEDVLTDGIQTFPDRTDRVYLNPQDCSVINDEALNRIIAVGHQHHLNVVGWNPGPALSVSMGDMPDDGYKTFVCVETAYTSEMQKVTKEKPAHLAQSIRVAKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-12-04" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GM0</accession>
    <name>STXB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Shiga toxin subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">stxB</name>
        <name type="ordered locus">SDY_1390</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Shiga toxin contains a single subunit A and five copies of subunit B.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">There are three Gb3-binding sites in each subunit B monomer, allowing for a tighter binding to the target cell. Binding sites 1 and 2 have higher binding affinities than site 3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the StxB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000752026.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403026.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GM0"/>
    <dbReference type="SMR" id="Q32GM0"/>
    <dbReference type="EnsemblBacteria" id="ABB61535">
        <property type="protein sequence ID" value="ABB61535"/>
        <property type="gene ID" value="SDY_1390"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1390"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1651"/>
    <dbReference type="HOGENOM" id="CLU_191376_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044177">
        <property type="term" value="C:host cell Golgi apparatus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019836">
        <property type="term" value="P:hemolysis by symbiont of host erythrocytes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008992">
        <property type="entry name" value="Enterotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003189">
        <property type="entry name" value="SLT_beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02258">
        <property type="entry name" value="SLT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50203">
        <property type="entry name" value="SSF50203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0800">Toxin</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000312306" description="Shiga toxin subunit B">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="89" mass="9743" checksum="C78F7795CCD7242E" modified="2005-12-06" version="1" precursor="true">MKKTLLIAASLSFFSASALATPDCVTGKVEYTKYNDDDTFTVKVGDKELFTNRWNLQSLLLSAQITGMTVTIKTNACHNGGGFSEVIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GN0</accession>
    <name>Q32GN0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">int</name>
        <name evidence="5" type="ordered locus">SDY_1380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005023250.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403016.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GN0"/>
    <dbReference type="EnsemblBacteria" id="ABB61525">
        <property type="protein sequence ID" value="ABB61525"/>
        <property type="gene ID" value="SDY_1380"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1380"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1637"/>
    <dbReference type="HOGENOM" id="CLU_027562_0_4_6"/>
    <dbReference type="OMA" id="WHIPASK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="213"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="409" mass="47260" checksum="927DA6AE6AB64C12" modified="2005-12-06" version="1">MCTLKCIRNTRVYTLLTDTKLRKSLGKKRDKIEVLSDAQGLNVRLSTSGSITFFYRYRWNGKAAQLAIGSYPSISLAQARERRQQFRDWLTEGQDPRRQVMLEKQKKSQAMTVKEAFDYWEQHYCIPEGLKKLKVNRRDFNNHIAPVLGNVIVEQTTKAHWLSLFDSMGRRVVTGQMLGLMQRTFRFCSNRGVISINPLESLRRSDVGMAAATRDRKLSDEEIKIVWSALSDMGERQKLVVKFLLMTGCRTAEIRTARWEWFDFNENTWTVPASEYKTGKTVRRALPPAIVKLMQEVKKTSVSQHVLTRARYNGPEDDKPPQQPHIALFSAQIIAKTGMKTWSLHDLRRTVATRLSELGAPPHVVEKLLGHHMSGVMARYNLHDYLEDQRHWLQVWQNYLEGLVDAPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GN3</accession>
    <name>Q32GN3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-binding protein of peptide transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sapF</name>
        <name evidence="5" type="ordered locus">SDY_1377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000573413.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403013.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GN3"/>
    <dbReference type="STRING" id="300267.SDY_1377"/>
    <dbReference type="EnsemblBacteria" id="ABB61522">
        <property type="protein sequence ID" value="ABB61522"/>
        <property type="gene ID" value="SDY_1377"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1377"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1634"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_6"/>
    <dbReference type="OMA" id="PEIDRKW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="268" mass="30598" checksum="A9B9816967D16B97" modified="2005-12-06" version="1">MIETLLEVRNLSKTFRYRTGWFRRQTVEAVKPLSFTLREGQTLAIIGENGSGKSTLAKMLAGMIEPTSGELLIDDHPLHFGDYSFRSQRIRMIFQDPSTSLNPRQRISQILDFPLRLNTNLEPEQRRKQIIETMRMVGLLPDHVSYYPHMLAPGQKQRLGLARALILRPKVIIADEALASLDMSMRSQLINLMLELQEKQGISYIYVTQHIGMMKHISDQVLVMHQGEVVERGSTADVLVSPLHELTKRLIAGHFGEALTADAWRKDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-12-04" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GP7</accession>
    <name>YCIZ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0509 protein YciZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yciZ</name>
        <name type="ordered locus">SDY_1362</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0509 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001288368.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402999.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GP7"/>
    <dbReference type="STRING" id="300267.SDY_1362"/>
    <dbReference type="EnsemblBacteria" id="ABB61508">
        <property type="protein sequence ID" value="ABB61508"/>
        <property type="gene ID" value="SDY_1362"/>
    </dbReference>
    <dbReference type="GeneID" id="66674890"/>
    <dbReference type="KEGG" id="sdy:SDY_1362"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1613"/>
    <dbReference type="HOGENOM" id="CLU_180697_1_0_6"/>
    <dbReference type="OMA" id="PKSPWEI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01641">
        <property type="entry name" value="UPF0509"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020887">
        <property type="entry name" value="UPF0509"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000312013" description="UPF0509 protein YciZ">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01641"/>
        </source>
    </evidence>
    <sequence length="57" mass="6441" checksum="3224BBD63FE648C1" modified="2005-12-06" version="1">MSEFDAQRVAERIDIVLDILVAGDYHSAIHNLEILKAELLRQVAESTPDIPKAPWEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H03</accession>
    <name>PTH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name type="ordered locus">SDY_1253</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000152942.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402893.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H03"/>
    <dbReference type="SMR" id="Q32H03"/>
    <dbReference type="STRING" id="300267.SDY_1253"/>
    <dbReference type="EnsemblBacteria" id="ABB61402">
        <property type="protein sequence ID" value="ABB61402"/>
        <property type="gene ID" value="SDY_1253"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1253"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1490"/>
    <dbReference type="HOGENOM" id="CLU_062456_3_1_6"/>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264107" description="Peptidyl-tRNA hydrolase">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <sequence length="194" mass="21138" checksum="BC59848E8E16CBCE" modified="2005-12-06" version="1">MTIKLIVGLANPGAEYAATRHNAGAWFVDLLAERLRAPLREEAKFFGYTSRVTLGGEDVRLLVPTTFMNLSGKAVAAMASFFRINPDEILVVHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRIGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAVRCTEMWFTDGLTKATNRLHAFKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H66</accession>
    <name>Q32H66_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">flhE</name>
        <name evidence="2" type="ordered locus">SDY_1183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001259578.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402830.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H66"/>
    <dbReference type="STRING" id="300267.SDY_1183"/>
    <dbReference type="EnsemblBacteria" id="ABB61339">
        <property type="protein sequence ID" value="ABB61339"/>
        <property type="gene ID" value="SDY_1183"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1183"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1398"/>
    <dbReference type="HOGENOM" id="CLU_140250_0_0_6"/>
    <dbReference type="OMA" id="TITTIYW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009420">
        <property type="entry name" value="FlhE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06366">
        <property type="entry name" value="FlhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220742" evidence="1">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="130" mass="14091" checksum="05F59A5A6E62B53A" modified="2005-12-06" version="1">MRTLLAILLFPLLVQAAGEGMWQASSVGITLNHRGESMSSAPLSTRQPASGLMTLVAWRYQLIGPTPAGLRVRLCSQSRCVELEGQSGTTVAFSGIAAVEPLRFIWEVPSGGRLIPSLKVQRNEVIVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HA4</accession>
    <name>Q32HA4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">High-affinity zinc uptake system protein ZnuA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yebL</name>
        <name evidence="8" type="ordered locus">SDY_1144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the high-affinity zinc uptake transport system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HA4"/>
    <dbReference type="STRING" id="300267.SDY_1144"/>
    <dbReference type="EnsemblBacteria" id="ABB61301">
        <property type="protein sequence ID" value="ABB61301"/>
        <property type="gene ID" value="SDY_1144"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1144"/>
    <dbReference type="HOGENOM" id="CLU_016838_1_2_6"/>
    <dbReference type="OMA" id="FHEAFDY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01019">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035520">
        <property type="entry name" value="ZnuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="328" mass="36009" checksum="D53871CA8B3D680F" modified="2005-12-06" version="1">MKCYNITLLIFITMIGRIMLHKKTLLFAALSAALWGGATQAADAAVVASLKPVGFIASAIADGVTETEVLLPDGASEHDYSLRPSDVKRLQNADLVVWVGPEMEAFMQKPVSKLPEAKQVTIAQLEDVKPLLMKSIHGDDDDHDHAEKSDEDHHHGDFNMHLWLSPEIARATAVAIHGKLVELMPQSRAKLDANLKDFEAQLASTETQVGNELAPFKGKGYFVFHDAYGYFEKQFGLTPLGHFTVNPEIQPGAQRLHEIRTQLVEQKATCVFAEPQFRPAVVESVARGTSVRMGTLDPLGTNIKLGKTSYSEFLSQLANQYASCLKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HA5</accession>
    <name>Q32HA5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yebA</name>
        <name evidence="7" type="ordered locus">SDY_1143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M23B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HA5"/>
    <dbReference type="STRING" id="300267.SDY_1143"/>
    <dbReference type="MEROPS" id="M23.011"/>
    <dbReference type="EnsemblBacteria" id="ABB61300">
        <property type="protein sequence ID" value="ABB61300"/>
        <property type="gene ID" value="SDY_1143"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1143"/>
    <dbReference type="HOGENOM" id="CLU_026846_0_2_6"/>
    <dbReference type="OMA" id="GPHVCYR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045834">
        <property type="entry name" value="Csd3_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19425">
        <property type="entry name" value="Csd3_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="419" mass="46672" checksum="B0E37B48B32402F2" modified="2005-12-06" version="1">MLGSLTVLTLAVAVWRPYVYHRDATPIVKTIELEQNEIRSLLPEASEPIDQAAQEDEAIPQDELDDKIAGEAGVHEYVVSTGDTLSSILNQYGIDMGDITQLAAADKELRNLKIGQQLSWTLTADGELQRLTWEVSRRETRTYDRTAANGFKMTSEMQQGEWVNNLLKGTVGGSFVASARNAGLTSAEVSAVIKAMQWQMDFRKLKKGDEFAVLMSREMLDGKREQSQLLGVRLRSEGKDYYAIRAEDGKFYDRNGTALAKGFLRFPTAKQFRISSNFNPRRTNPVTGRVAPHRGVDFAMPQGTPVLSVGDGEVVVAKRSGAAGYYVAIRHGRSYTTRYMHLRKILVEPGQKVKRGDRIALSGNTGRSTGPHLHYEVWINQQAVNPLTAKLPRTEGLTGSDRREFLAQAKEIVPQLRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HC8</accession>
    <name>Q32HC8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-arabinose-binding periplasmic protein</fullName>
            <shortName evidence="1">ABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">araF</name>
        <name evidence="4" type="ordered locus">SDY_1120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000548680.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402768.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HC8"/>
    <dbReference type="STRING" id="300267.SDY_1120"/>
    <dbReference type="EnsemblBacteria" id="ABB61277">
        <property type="protein sequence ID" value="ABB61277"/>
        <property type="gene ID" value="SDY_1120"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1120"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1320"/>
    <dbReference type="HOGENOM" id="CLU_046821_1_0_6"/>
    <dbReference type="OMA" id="EWKFADQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042882">
        <property type="term" value="P:L-arabinose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01540">
        <property type="entry name" value="PBP1_arabinose_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026266">
        <property type="entry name" value="AraF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002816">
        <property type="entry name" value="AraF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005153696" description="L-arabinose-binding periplasmic protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_1" evidence="3">
        <location>
            <begin position="26"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="site" description="The binding site for the sugar molecule has not yet been established, but C-87 may be involved" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR002816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="329" mass="35503" checksum="6E1A2E1878401499" modified="2005-12-06" version="1">MHKFTKALAAIGLAAVMSQSAMAENLKLGFLVKQPEEPWFQTEWKFADKAGKDLGFEVIKIAVPDGEKTLNAIDSLAASGAKGFVICTPDPKLGSAIVAKARGYDMKVIAVDDQFVNAKGKPMDTVPLVMMAATKIGERQGQELYKEMQKRGWDVKESAVMAITSNELDTARRRTTGSMDALKAAGFPEKQIYQVPTKSNDIPGAFDAANSMLVQHPEVKHWLIVGMNDSTVLGGVRATEGQGFKAADIIGIGINGVDAVSELSKAQATGFYGSLLPSPDVHGYKSSEMLYNWVAKGVEPTKFTEVTDVVLITRDNFKEELEKKGLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HK3</accession>
    <name>Q32HK3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HK3"/>
    <dbReference type="EnsemblBacteria" id="ABB61202">
        <property type="protein sequence ID" value="ABB61202"/>
        <property type="gene ID" value="SDY_1037"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1037"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="99" mass="10912" checksum="70DEDA0EBC31C948" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITETFKILFLEIVPGFKYDTVIASSRSLLGPQCLNSSILICFGGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HN1</accession>
    <name>Q32HN1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yeeV</name>
        <name evidence="1" type="ordered locus">SDY_1009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001094433.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402665.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HN1"/>
    <dbReference type="STRING" id="300267.SDY_1009"/>
    <dbReference type="EnsemblBacteria" id="ABB61174">
        <property type="protein sequence ID" value="ABB61174"/>
        <property type="gene ID" value="SDY_1009"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1009"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1177"/>
    <dbReference type="HOGENOM" id="CLU_129204_1_0_6"/>
    <dbReference type="OMA" id="EVSCCPS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009610">
        <property type="entry name" value="CbtA_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06755">
        <property type="entry name" value="CbtA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="124" mass="13919" checksum="B7184A06AD12E87B" modified="2005-12-06" version="1">MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGFSACTRSPLINSIDILRARRVTGLMTRDNYRTVNNITLGKHPEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HN8</accession>
    <name>Q32HN8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycdZ</name>
        <name evidence="2" type="ordered locus">SDY_1001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402658.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HN8"/>
    <dbReference type="STRING" id="300267.SDY_1001"/>
    <dbReference type="EnsemblBacteria" id="ABB61167">
        <property type="protein sequence ID" value="ABB61167"/>
        <property type="gene ID" value="SDY_1001"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1001"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1170"/>
    <dbReference type="HOGENOM" id="CLU_104628_0_0_6"/>
    <dbReference type="OMA" id="WGWVAIS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009476">
        <property type="entry name" value="DUF1097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06496">
        <property type="entry name" value="DUF1097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="179" mass="18760" checksum="E71AAD9D48EAB790" modified="2005-12-06" version="1">MCSISFMAAFSAIMHGMNILLSIAITTGILSGIWGWVAVSLGLLSWAGFLGCTAYFACPQGGLKGLAISAATLLSGVVWAMVIIYGSALAPHLEILGYVITGIVAFLMCIQAKQLLLSFVPGTFIGACATFAGQGDWKLVLPSLALGLIFGYAMKNSGLWLAARSAKTAHREQEIKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HR7</accession>
    <name>Q32HR7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yccM</name>
        <name evidence="3" type="ordered locus">SDY_0966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402629.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HR7"/>
    <dbReference type="STRING" id="300267.SDY_0966"/>
    <dbReference type="EnsemblBacteria" id="ABB61138">
        <property type="protein sequence ID" value="ABB61138"/>
        <property type="gene ID" value="SDY_0966"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0966"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1116"/>
    <dbReference type="HOGENOM" id="CLU_1568367_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="97"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="186" mass="21146" checksum="FBDC715375375176" modified="2005-12-06" version="1">MAENKRTRWQRRPGTTGGKLPWNDWRNATTWRKATQLLLLAMNIYIAITFWYWVRYYETAGSTIFVARPGGIEGWLPIAGLMNLKYSLATGQLPSVHAAAMLLLVAFIVISLLLKKAFCSWLCPVGTLSELIGDLGNKLFGRQFVLPRWLDIPLRGVKYLLLSFFLYIALLMPAQAIHYLVMPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HS4</accession>
    <name>Q32HS4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative function in exopolysaccharide production</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">yccZ</name>
        <name evidence="17" type="ordered locus">SDY_0959</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BexD/CtrA/VexA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020302.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402622.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HS4"/>
    <dbReference type="STRING" id="300267.SDY_0959"/>
    <dbReference type="EnsemblBacteria" id="ABB61131">
        <property type="protein sequence ID" value="ABB61131"/>
        <property type="gene ID" value="SDY_0959"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0959"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1107"/>
    <dbReference type="HOGENOM" id="CLU_038343_4_2_6"/>
    <dbReference type="OMA" id="LQFPYAG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040716">
        <property type="entry name" value="Wza_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18412">
        <property type="entry name" value="Wza_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0625">Polysaccharide transport</keyword>
    <keyword evidence="10" id="KW-0626">Porin</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221128" evidence="14">
        <location>
            <begin position="23"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="15">
        <location>
            <begin position="173"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="15">
        <location>
            <begin position="256"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Wza_C" evidence="16">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB61131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="379" mass="41697" checksum="401431ED78C6CB33" modified="2005-12-06" version="1">MKKNIFKFSVLTLAVLSLTACTLVPGQNLSTSNKDVIELPDNQYDLDKMVNIYPVTPGLIAQLRAKPIMSQANPELEQQIANYEYRIGIGDVLMVTVWDHPELTTPAGQYRSASDTGNWVNADGAIFYPYIGRLKVAGKTLTQVRNEITARLDSVIESPQVDVSVAAFRSQKAYVTGEVSKSGQQPITNIPLTIMDAINAAGGLTADADWRNVVLTQNGVKTKVNLYALMQRGDLRQNKLLHPGDILFIPRNDDLKVFVMGEVGKQSTLKMDRSGMTLAEALGNAEGMNQDVADATGIFVIRATQNKQNGKIANIYQLNAKDASAMILGTEFQLEPYDIVYVTTAPLARWNRVISLLVPTISGVHDLTETSRWIQTWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ID4</accession>
    <name>Q32ID4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putrescine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potH</name>
        <name evidence="8" type="ordered locus">SDY_0739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000105439.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402412.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ID4"/>
    <dbReference type="STRING" id="300267.SDY_0739"/>
    <dbReference type="EnsemblBacteria" id="ABB60923">
        <property type="protein sequence ID" value="ABB60923"/>
        <property type="gene ID" value="SDY_0739"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0739"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.853"/>
    <dbReference type="HOGENOM" id="CLU_016047_18_3_6"/>
    <dbReference type="OMA" id="YPIAYGM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="99"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="317" mass="35494" checksum="917C8DD93896A271" modified="2005-12-06" version="1">MSTLEPAAQSKPPGGFKLWLSQLQMKHGRKLVIALPYIWLILLFLLPFLIVFKISLAEMARAIPPYTELMEWDDGQLSITLNFGNFLQLTDDPLYFDAYLQSLQVAAISTFCCLLIGYPLAWAVAHSNPSTRNILLLLVILPSWTSFLIRVYAWMGILKNNGVLNNFLLWLGVIDQPLTILHTNLAVYIGIVYAYVPFMVLPIYTALIRIDYSLVEAALDLGARPLKTFFTVIVPLTKGGIIAGSMLVFIPAVGEFVIPELLGGPDSIMIGRVLWQEFFNNPDWPVASAVAIIMLLLLIVPIMWFHKHQQKSVGEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32II0</accession>
    <name>Q32II0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidoglycan-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">pal</name>
        <name evidence="13" type="ordered locus">SDY_0689</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Pal lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019976.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402366.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32II0"/>
    <dbReference type="STRING" id="300267.SDY_0689"/>
    <dbReference type="EnsemblBacteria" id="ABB60877">
        <property type="protein sequence ID" value="ABB60877"/>
        <property type="gene ID" value="SDY_0689"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0689"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.803"/>
    <dbReference type="HOGENOM" id="CLU_016890_9_4_6"/>
    <dbReference type="OMA" id="MNQGEET"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02204">
        <property type="entry name" value="Pal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039001">
        <property type="entry name" value="Pal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014169">
        <property type="entry name" value="Pal_lipo_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02802">
        <property type="entry name" value="Pal_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6 13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220772" description="Peptidoglycan-associated protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="12">
        <location>
            <begin position="60"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB60877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="173" mass="18797" checksum="DD8E6959C036B43C" modified="2005-12-06" version="1">MQLNKVLKGLMIALPVMAIAACSSNKNASNDGSEGMLGAGTGMDASGGNGNMSSEEQARLQMQQLQQNNIVYFDLDKYDIRSDFAQMLDAHANFLRSNPSYKVTVEGHADERGTPEYNISLGERRANAVKMYLQGKGVSADQISIVSYGKEKPAVLGHDEAAYSKNRRAVLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IV1</accession>
    <name>Q32IV1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator LYSR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybeF</name>
        <name evidence="3" type="ordered locus">SDY_0551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402245.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IV1"/>
    <dbReference type="STRING" id="300267.SDY_0551"/>
    <dbReference type="EnsemblBacteria" id="ABB60756">
        <property type="protein sequence ID" value="ABB60756"/>
        <property type="gene ID" value="SDY_0551"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0551"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.652"/>
    <dbReference type="HOGENOM" id="CLU_039613_39_5_6"/>
    <dbReference type="OMA" id="ERRCGFS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="311" mass="35528" checksum="B551AC7691286199" modified="2005-12-06" version="1">MLNLTPSAISQSIQKLRVIFPDPLFIRKGQGVTPTAFAMHLHEYISQGLESILGALDIAGSYDKQRTITIATTPSVGALVLPVIYRAIKTHYPQLLLRNPPISDAENQLSQFQTDLIIDNMFCTNRTVQHHVLFTDNMVLICREGNPLLSLEDDRETIDNAAHVLLLPEGQNFSGLRQRIQEMFPDRQISFTSFTSYTSYNSYNSYNSYNSYNSYNSYNSYNSYNSYNSYNSYNSYNSYNILTIAALVANSDMLAIIPSRFYNLFSRCWPLEKLPFPSLNEEQIDFSIHYNKFSLRAPILHGVIDVIRNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IX6</accession>
    <name>Q32IX6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">entC</name>
        <name evidence="6" type="ordered locus">SDY_0524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000381303.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402220.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IX6"/>
    <dbReference type="SMR" id="Q32IX6"/>
    <dbReference type="STRING" id="300267.SDY_0524"/>
    <dbReference type="EnsemblBacteria" id="ABB60731">
        <property type="protein sequence ID" value="ABB60731"/>
        <property type="gene ID" value="SDY_0524"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0524"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.617"/>
    <dbReference type="HOGENOM" id="CLU_006493_8_6_6"/>
    <dbReference type="OMA" id="TMWHLSS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="126"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="391" mass="42932" checksum="62882569DFC41AC4" modified="2005-12-06" version="1">MDTSLAEEVQQTMATLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J18</accession>
    <name>Q32J18_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001624623.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402178.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J18"/>
    <dbReference type="STRING" id="300267.SDY_0482"/>
    <dbReference type="EnsemblBacteria" id="ABB60689">
        <property type="protein sequence ID" value="ABB60689"/>
        <property type="gene ID" value="SDY_0482"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0482"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.567"/>
    <dbReference type="HOGENOM" id="CLU_2522548_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="88" mass="9949" checksum="7D073B6D383B61B5" modified="2005-12-06" version="1">MEWYMGKYIRPLSDAVFTIASDDLWIESLAIQQLHTTANLPNMQRVVGMPDLHPGRGYPIGAAFFSVGRFYPTRRRGNGAGNRNRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J43</accession>
    <name>Q32J43_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acridine efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acrA</name>
        <name evidence="6" type="ordered locus">SDY_0456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019446.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402153.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J43"/>
    <dbReference type="STRING" id="300267.SDY_0456"/>
    <dbReference type="EnsemblBacteria" id="ABB60664">
        <property type="protein sequence ID" value="ABB60664"/>
        <property type="gene ID" value="SDY_0456"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0456"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.539"/>
    <dbReference type="HOGENOM" id="CLU_018816_2_1_6"/>
    <dbReference type="OMA" id="INVRYTK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220879" evidence="3">
        <location>
            <begin position="22"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="4">
        <location>
            <begin position="38"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="63"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="397" mass="42212" checksum="66711C9FA2FE3F13" modified="2005-12-06" version="1">MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGMLKQENGKAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLLKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J62</accession>
    <name>Q32J62_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybaQ</name>
        <name evidence="2" type="ordered locus">SDY_0435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402134.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J62"/>
    <dbReference type="STRING" id="300267.SDY_0435"/>
    <dbReference type="EnsemblBacteria" id="ABB60645">
        <property type="protein sequence ID" value="ABB60645"/>
        <property type="gene ID" value="SDY_0435"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0435"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.516"/>
    <dbReference type="HOGENOM" id="CLU_140230_3_2_6"/>
    <dbReference type="OMA" id="GNSAKFW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15150" checksum="115D35EE925B1489" modified="2005-12-06" version="1">MIQYVLVSLFTGKQQLKTMKQATRKPTTPGDILLYEYLEPLALKINGLAELLHVHRNSVSTLINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLWEVENNMRTQEELGRIETVAEYLARREERAIKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J97</accession>
    <name>Q32J97_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator LYSR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybbS</name>
        <name evidence="3" type="ordered locus">SDY_0398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000460148.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402099.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J97"/>
    <dbReference type="STRING" id="300267.SDY_0398"/>
    <dbReference type="EnsemblBacteria" id="ABB60610">
        <property type="protein sequence ID" value="ABB60610"/>
        <property type="gene ID" value="SDY_0398"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0398"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.472"/>
    <dbReference type="HOGENOM" id="CLU_039613_35_1_6"/>
    <dbReference type="OMA" id="VYMGVWD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="308" mass="34526" checksum="43B463B4675790B6" modified="2005-12-06" version="1">MFDPETLRTFIAVAETGSFSKAAERLCKTTATISYRIKLLEENTGVALFFRTTRSVTLTAAGEHLLSQARDWLSWLESMPSELQQVNDGVERQVNIVINNLLYNPQAVAQLLAWLNERYPFTQFHISRQIYMGVWDSLLYEGFSLAIGVTGTEALANTFSLEPLGSVQWRFVMAADHPLANVEEPLTEAQLRRFPAVNIEDSARTLTKRVAWRLPGQKEIIVPDMETKIAAHLAGVGIGFLPKSLCQSMIDNQQLVSRVIPTMRPPSPLSLAWRKFGSGKAVEDIVTLFTQRRPEISGFLEIFGNPRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JB6</accession>
    <name>BGAL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-galactosidase</fullName>
            <shortName evidence="1">Beta-gal</shortName>
            <ecNumber evidence="1">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lacZ</name>
        <name type="ordered locus">SDY_0378</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </cofactor>
        <text evidence="1">Binds 1 sodium ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB60591" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60591.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JB6"/>
    <dbReference type="SMR" id="Q32JB6"/>
    <dbReference type="STRING" id="300267.SDY_0378"/>
    <dbReference type="CAZy" id="GH2">
        <property type="family name" value="Glycoside Hydrolase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60591">
        <property type="protein sequence ID" value="ABB60591"/>
        <property type="gene ID" value="SDY_0378"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0378"/>
    <dbReference type="HOGENOM" id="CLU_002346_0_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01687">
        <property type="entry name" value="Beta_gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023933">
        <property type="entry name" value="Glyco_hydro_2_beta_Galsidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0915">Sodium</keyword>
    <feature type="chain" id="PRO_0000367009" description="Beta-galactosidase">
        <location>
            <begin position="1"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="538"/>
            <end position="541"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1000"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1024" mass="116614" checksum="D0D9021809CAA06A" modified="2009-03-24" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JD4</accession>
    <name>Q32JD4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
            <ecNumber evidence="2">2.7.7.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yaiC</name>
        <name evidence="5" type="ordered locus">SDY_0358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24898"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="2.7.7.65"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000484075.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402062.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JD4"/>
    <dbReference type="STRING" id="300267.SDY_0358"/>
    <dbReference type="EnsemblBacteria" id="ABB60573">
        <property type="protein sequence ID" value="ABB60573"/>
        <property type="gene ID" value="SDY_0358"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0358"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.419"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_1_6"/>
    <dbReference type="OMA" id="HGAWKDL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007894">
        <property type="entry name" value="MASE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05230">
        <property type="entry name" value="MASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="240"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="371" mass="41598" checksum="729BC23FBED1027B" modified="2005-12-06" version="1">MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFTRRVRLPRAVGLAGMFLPIASTLVSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDTVLAGMWVGVMGVNVLPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JD5</accession>
    <name>Q32JD5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="3">P5C reductase</shortName>
            <shortName evidence="3">P5CR</shortName>
            <ecNumber evidence="3 4">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">proC</name>
        <name evidence="7" type="ordered locus">SDY_0356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="3 4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020551.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402061.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JD5"/>
    <dbReference type="STRING" id="300267.SDY_0356"/>
    <dbReference type="EnsemblBacteria" id="ABB60571">
        <property type="protein sequence ID" value="ABB60571"/>
        <property type="gene ID" value="SDY_0356"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0356"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.418"/>
    <dbReference type="HOGENOM" id="CLU_042344_3_1_6"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="5">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="6">
        <location>
            <begin position="163"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="269" mass="28276" checksum="CB186B2670CC5089" modified="2005-12-06" version="1">MEKKIGFIGCGNMGKAILGGLIASGQVLPRQIWVYTPSPDKVAALHDQFGINAAESAQEVAQIADIIFAAVKPGIMIKVLSEITSSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMPNTPALVNAGMTSVTPNALVTPEDTADMLNIFRCFGEAEVIAEPMIHPVVGVSGSSPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLETGEHPGALKDMVCSPGGTTIEAVRVLEEKGFRAAVIEAMTKCMEKSEKLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JQ2</accession>
    <name>Q32JQ2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidoglycan lytic exotransglycosylase</fullName>
            <ecNumber evidence="3">4.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dniR</name>
        <name evidence="7" type="ordered locus">SDY_0230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exolytic cleavage of the (1-&gt;4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.</text>
            <dbReference type="EC" id="4.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.n1" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000644696.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401944.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JQ2"/>
    <dbReference type="STRING" id="300267.SDY_0230"/>
    <dbReference type="CAZy" id="CBM50">
        <property type="family name" value="Carbohydrate-Binding Module Family 50"/>
    </dbReference>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60455">
        <property type="protein sequence ID" value="ABB60455"/>
        <property type="gene ID" value="SDY_0230"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0230"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.259"/>
    <dbReference type="HOGENOM" id="CLU_009520_1_4_6"/>
    <dbReference type="OMA" id="ARHMPTE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="341"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="400"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="452" mass="49446" checksum="6C1D5B2EE08948B5" modified="2005-12-06" version="1">MKAKAILLASVLLVGCQSTGNVQQHAQSLSAAGQGEAAKFTSQARWMDDGTSIAPDGDLWAFIGDELKMGIPENDRIREQKQKYLRNKSYLHDVTLRAEPYMYWIAGQVKKRNMPMELVLLPIVESAFDPHATSGANAAGIWQIIPSTGRNYGLKQTRNYDARRDVVASTTAALNMMRRLNKMFDGDWLLTVAAYNSGEGRVMKAIKTNKARGKSTDFWSLPLPQETKQYVPKMLALSDILKNSKRYGVRLPTTDESRALARVHLSSPVEMAKVADMAGISVSKLKTFNAGVKGSTLGASGPQYVMVPKKHADQLRESLASGEIAAVQSTLVADNTPLNSRVYTVRSGDTLSSIASRLGVSTKDLQQWNKLRGSKLKPGQSLTIGAGSSAQRLANNSDSITYRVRKGDSLSSIAKRHGVNIKDVMRWNSDTANLQPGDKLTLFVKNNNMPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JY1</accession>
    <name>Q32JY1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroP</name>
        <name evidence="8" type="ordered locus">SDY_0142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378543.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401865.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JY1"/>
    <dbReference type="STRING" id="300267.SDY_0142"/>
    <dbReference type="EnsemblBacteria" id="ABB60376">
        <property type="protein sequence ID" value="ABB60376"/>
        <property type="gene ID" value="SDY_0142"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0142"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.160"/>
    <dbReference type="HOGENOM" id="CLU_007946_9_3_6"/>
    <dbReference type="OMA" id="VIMYLTP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="457" mass="49690" checksum="81DBFA5C877154D4" modified="2005-12-06" version="1">MMEGQQHGEQLKRGLKNRHIQLIALGGAIGTGLFLGSASVIQSAGPGIILGYAIAGFIAFLIMRQLGEMVVEEPVAGSFSHFAYKYWGSFAGFASGWNYWVLYVLVAMAELTAVGKYIQFWYPEIPTWASAAVFFVVINAINLTNVKVFGEMEFWFAIIKVIAVVAMIIFGGWLLFSGNGGPQATVSNLWDQGGFLPHGFTGLVMMMAIIMFSFGGLELVGITAAEADNPEQSIPKATNQVIYRILIFYIGSLAVLLSLMPWTRVTADTSPFVLIFHELGDTFVANALNIVVLTAALSVYNSCVYCNSRMLFGLAQQGNAPKALASVDKRGVPVNTILVSALVTALCVLINYLAPESAFGLLMALVVSALVINWAMISLAHMKFRRARQEQGVVTRFPALLYPLGNWICLLFMAAVLVIMLMTPGMAISVYLIPVWLIVLGIGYLFKEKTAKAVKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JY5</accession>
    <name>Q32JY5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prelipin peptidase dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppdD</name>
        <name evidence="3" type="ordered locus">SDY_0138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000360691.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401861.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JY5"/>
    <dbReference type="STRING" id="300267.SDY_0138"/>
    <dbReference type="EnsemblBacteria" id="ABB60372">
        <property type="protein sequence ID" value="ABB60372"/>
        <property type="gene ID" value="SDY_0138"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0138"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.156"/>
    <dbReference type="HOGENOM" id="CLU_091705_4_1_6"/>
    <dbReference type="OMA" id="RILTWDC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="146" mass="15660" checksum="E379B240F4E73FDC" modified="2005-12-06" version="1">MDKQHGFTLIELMVVIGIIAILSAIGIPAYQNYLRKAALTDMLQTFVPYRTAVELCALEHGGLDTCDGGSNGIPSPTTTRYVSAMSVAKGVVSLTGQESLNGLSVVMTPGWDNANGVTGWTRNCNIQNDSALQQACEDVFRFDDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K51</accession>
    <name>Q32K51_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_0068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K51"/>
    <dbReference type="STRING" id="300267.SDY_0068"/>
    <dbReference type="EnsemblBacteria" id="ABB60306">
        <property type="protein sequence ID" value="ABB60306"/>
        <property type="gene ID" value="SDY_0068"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0068"/>
    <dbReference type="HOGENOM" id="CLU_2636083_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="77" mass="8226" checksum="F5E6E7F3C0F75BAB" modified="2005-12-06" version="1">MLIGSFAMMTLALAVLGLIPDMGIWLVVMAFAVYAFFSGGPGNLQWLYPNELFPTDIRASAVGVIMSLSRIGTIVST</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-12-04" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KB7</accession>
    <name>LPT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">thr operon leader peptide</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">thr operon attenuator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrL</name>
        <name type="ordered locus">SDY_0001</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in control of the biosynthesis of threonine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thr operon leader peptide family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001386572.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401729.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KB7"/>
    <dbReference type="EnsemblBacteria" id="ABB60241">
        <property type="protein sequence ID" value="ABB60241"/>
        <property type="gene ID" value="SDY_0001"/>
    </dbReference>
    <dbReference type="GeneID" id="67416081"/>
    <dbReference type="KEGG" id="sdy:SDY_0001"/>
    <dbReference type="HOGENOM" id="CLU_221491_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031556">
        <property type="term" value="P:transcriptional attenuation by ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01907">
        <property type="entry name" value="Leader_Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011720">
        <property type="entry name" value="Thr_lead_pept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08254">
        <property type="entry name" value="Leader_Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02077">
        <property type="entry name" value="thr_lead_pep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0428">Leader peptide</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="peptide" id="PRO_0000312893" description="thr operon leader peptide">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01907"/>
        </source>
    </evidence>
    <sequence length="21" mass="2138" checksum="6A9C9167F89EECE4" modified="2005-12-06" version="1">MKRISTTITTTITITTGNGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-05-15" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A4SH27</accession>
    <name>A4SH27_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RfpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfpB</name>
        <name evidence="2" type="ordered locus">SDY_PA04</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD197_spA</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD197_spA</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000640">
        <property type="protein sequence ID" value="ABO87498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000703236.1">
        <property type="nucleotide sequence ID" value="NC_009344.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_001139947.1">
        <property type="nucleotide sequence ID" value="NC_009344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A4SH27"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABO87498">
        <property type="protein sequence ID" value="ABO87498"/>
        <property type="gene ID" value="SDY_PA04"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_PA04"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5783"/>
    <dbReference type="HOGENOM" id="CLU_009583_8_1_6"/>
    <dbReference type="OMA" id="SYYREGI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD197_spA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="192"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABO87498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="377" mass="41817" checksum="5325A52D528AB50E" modified="2007-05-15" version="1">MKISIIGNTANAMILFRLDLIKTLTKKGISVYAFATDYNDSSKEIIKKAGAIPVDYNLSRSGINLAGDLWNTYLLSKKLKKIKPDAILSFFSKPSIFGSLAGIFSGVKNNNAMLEGLGFLFTEQPHGTPLKTKLLKNIQVLLYKIIFPHINSLILLNKDDYHDLIDKYKIKLKSCHILGGIGLDMNNYCKSTPPTNEISFIFIARLLAEKGVNEFVAAAKKIKKTHPNVEFIILGAIDKENPGGLSESDVDTLIKSGVISYPGFVSNVADWIEKSSVFVLPSYYREGVPRSTQEAMAMGRPILTTNLPGCKETIIDGVNGYVVKKWSHEDLAEKMLKLINNPEKIISMGEESYKLARERFDANVNNVKLLKILGIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q326M2</accession>
    <name>Q326M2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378983.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406224.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326M2"/>
    <dbReference type="EnsemblBacteria" id="ABB64736">
        <property type="protein sequence ID" value="ABB64736"/>
        <property type="gene ID" value="SDY_P223"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P223"/>
    <dbReference type="HOGENOM" id="CLU_3205245_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038334">
        <property type="entry name" value="NleF_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="45" mass="5245" checksum="0A61B5B6A87E9E5E" modified="2005-12-06" version="1">MTTTELFWDLNAIKWLVEGRGDDVSPFENIPVPDLTYNKEAWQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q326N5</accession>
    <name>Q326N5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P063</name>
        <name evidence="2" type="ordered locus">SDY_P209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
            <plasmid evidence="2">pSD1_197</plasmid>
            <plasmid evidence="2">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406063.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406211.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64576">
        <property type="protein sequence ID" value="ABB64576"/>
        <property type="gene ID" value="SDY_P063"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64722">
        <property type="protein sequence ID" value="ABB64722"/>
        <property type="gene ID" value="SDY_P209"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P063"/>
    <dbReference type="KEGG" id="sdy:SDY_P209"/>
    <dbReference type="HOGENOM" id="CLU_153781_1_0_6"/>
    <dbReference type="OMA" id="MNSGCQI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9031" checksum="4529D37A5380329F" modified="2005-12-06" version="1">MASFFPEAVELRLRKISGSLAKDIVTAAQFTIFTLQLFQTLTFSGGEPSITAPGIPLMLANPDTQSLRRTANLWSNGTNCRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q326P6</accession>
    <name>Q326P6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406200.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326P6"/>
    <dbReference type="EnsemblBacteria" id="ABB64712">
        <property type="protein sequence ID" value="ABB64712"/>
        <property type="gene ID" value="SDY_P199"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P199"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5751"/>
    <dbReference type="HOGENOM" id="CLU_036902_12_7_6"/>
    <dbReference type="OMA" id="WGRTALY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7613" checksum="81105CB0CF10AEC6" modified="2005-12-06" version="1">MCWGRTALYMAALEAPRFNLVIKAFYMRLLAAGNAKKVALVACMRKLLTIMNAMLRKNEKWNESYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q326S8</accession>
    <name>Q326S8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IpgC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ipgC</name>
        <name evidence="2" type="ordered locus">SDY_P167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LcrH/SycD chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000055835.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406168.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326S8"/>
    <dbReference type="SMR" id="Q326S8"/>
    <dbReference type="EnsemblBacteria" id="ABB64680">
        <property type="protein sequence ID" value="ABB64680"/>
        <property type="gene ID" value="SDY_P167"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P167"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5726"/>
    <dbReference type="HOGENOM" id="CLU_093829_1_0_6"/>
    <dbReference type="OMA" id="NEPRFPF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005415">
        <property type="entry name" value="T3SS_Ca_resp_chp_LcrH/SycD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016379">
        <property type="entry name" value="T3SS_Ca_resp_chp_LcrH/SycD_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011716">
        <property type="entry name" value="TPR-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07720">
        <property type="entry name" value="TPR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003165">
        <property type="entry name" value="Chaperone_SicA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01595">
        <property type="entry name" value="SYCDCHAPRONE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02552">
        <property type="entry name" value="LcrH_SycD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="155" mass="17756" checksum="F46E39A92B8ADEC7" modified="2005-12-06" version="1">MSLNITENESISTAVIDAINSGATLKDINAIPDDMMDDIYSYAYDFYNKGRIEEAEVFFRFLCIYDFYNVDYIMGLAAIYQIKEQFQQAADLYAVAFALGKNDYTPVFHTGQCQLRLKAPLKAKECFELVIQHSNDEKLKIKAQSYLDAIQDIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Y4</accession>
    <name>Q326Y4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406112.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Y4"/>
    <dbReference type="EnsemblBacteria" id="ABB64624">
        <property type="protein sequence ID" value="ABB64624"/>
        <property type="gene ID" value="SDY_P111"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P111"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5666"/>
    <dbReference type="HOGENOM" id="CLU_1244633_0_0_6"/>
    <dbReference type="OMA" id="IFCTIHT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="222" mass="25021" checksum="F1E772A62CA304B4" modified="2005-12-06" version="1">MCRLAVENLLYAARKRGLEIGIFCTIHTLRLHFEEHLPLVVAGRRLGVPKSTACSMFVRFRKAGLSWPLPAGMSERELDARLYGSASTVPVVLTESTVMPEVPGGKKRPRRPNFPYEFKIALVEQSLQPGACVAQIARENGINDNLLFNWRHQYRKGGLLPSGKNMPALLPVTLTPEPDNHGFDIIYTLSTHHQRFTFVRLFDPYLIGSRSTFSHLAHHHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Z1</accession>
    <name>Q326Z1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative IS orf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406105.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Z1"/>
    <dbReference type="EnsemblBacteria" id="ABB64617">
        <property type="protein sequence ID" value="ABB64617"/>
        <property type="gene ID" value="SDY_P104"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P104"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5658"/>
    <dbReference type="HOGENOM" id="CLU_179902_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="80" mass="8854" checksum="CE99ACC728118FD9" modified="2005-12-06" version="1">MLTELRTRAYPCPPLTPRSTVCGLFARFRKSGLSWPLPAGMSEQKLDALLYGSASTVPVVLTESTVMPKLPVVKKRPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q327B4</accession>
    <name>Q327B4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS2 orf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406082.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327B4"/>
    <dbReference type="EnsemblBacteria" id="ABB64594">
        <property type="protein sequence ID" value="ABB64594"/>
        <property type="gene ID" value="SDY_P081"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P081"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5631"/>
    <dbReference type="HOGENOM" id="CLU_027402_25_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8315" checksum="19318F842D1EA449" modified="2005-12-06" version="1">MYLKIRDRLGYMSNTSSNFEMTGTLLGLELRKRKTPQEKIAIIQQTMEPGMTVSHVARLHGIQPSLLLKWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q327B9</accession>
    <name>Q327B9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406077.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327B9"/>
    <dbReference type="EnsemblBacteria" id="ABB64589">
        <property type="protein sequence ID" value="ABB64589"/>
        <property type="gene ID" value="SDY_P076"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P076"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5624"/>
    <dbReference type="HOGENOM" id="CLU_135054_1_0_6"/>
    <dbReference type="OMA" id="CLFNTAC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023136">
        <property type="entry name" value="Api92-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009694">
        <property type="entry name" value="DUF1281"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06924">
        <property type="entry name" value="DUF1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="14691" checksum="4725AECA2216B740" modified="2005-12-06" version="1">MPNWCSNRMYFSGEPAQIAEIKRLASGAVTPLYRRATNEGIQLFLAGSAGFLQITENIRSEQCPGVTAAGRGAVSTENIAFTRWLTHLQNGVLLDEQNCLMLHELWLQSGTGQRRWVRCTGNSGHYHLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q327I8</accession>
    <name>Q327I8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ISEc8 orf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_P007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Sd197</strain>
            <plasmid evidence="5">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406008.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327I8"/>
    <dbReference type="EnsemblBacteria" id="ABB64520">
        <property type="protein sequence ID" value="ABB64520"/>
        <property type="gene ID" value="SDY_P007"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P007"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5537"/>
    <dbReference type="HOGENOM" id="CLU_023034_7_3_6"/>
    <dbReference type="OMA" id="AKTERWI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024474">
        <property type="entry name" value="Znf_dom_IS66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13005">
        <property type="entry name" value="zf-IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-IS66" evidence="3">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="2">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="133" mass="14456" checksum="C72FD6FCE5FF1217" modified="2005-12-06" version="1">MAETLGEQYDPVLPSSLRQSSARKPLPASLPRAPRVIRPEEECCPACGGELSPLGCDVSEQLELISSAFKVIEKQRPKLACRRCDHIVQAPVPSKPIARSYAGAGLLAHVVTGKYADHLPLYRQSDLLFHAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q327M8</accession>
    <name>Q327M8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fhuF</name>
        <name evidence="3" type="ordered locus">SDY_4625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000331586.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405968.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327M8"/>
    <dbReference type="STRING" id="300267.SDY_4625"/>
    <dbReference type="EnsemblBacteria" id="ABB64477">
        <property type="protein sequence ID" value="ABB64477"/>
        <property type="gene ID" value="SDY_4625"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4625"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5486"/>
    <dbReference type="HOGENOM" id="CLU_088228_0_0_6"/>
    <dbReference type="OMA" id="HLDVVWL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008090">
        <property type="entry name" value="Fe_iron_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01714">
        <property type="entry name" value="2FE2SRDCTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03951">
        <property type="entry name" value="Fe_III_red_FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF" evidence="1">
        <location>
            <begin position="93"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF_C" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="262" mass="29966" checksum="A8430E38ABCD409C" modified="2005-12-06" version="1">MAYRSAPLYEDVIWRTHLQPQDAGLAQAVRATIAEHREHLLEFICLDEPAPLNAMTLAQWSSPNALSSLLAVYSDHIYRNQPLMIRENKPLISLWAQWYIGLMVPPLMLALLTQEKALDVSPEHFHVEFHETGRAACFWVDVCEDKNATPHSPQQRMETLISQALVPVVQALEATGEINGKLIWSNTGYLINWYLTEMKQLLGEATVESLRHALFFEKMLTNGEDNPLWRTVVLRDGLLVRRTCCQRYRLPDVQQCGDCTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q328R2</accession>
    <name>Q328R2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Citrate-dependent iron(III) transport protein cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fecC</name>
        <name evidence="8" type="ordered locus">SDY_4295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000125178.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405684.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328R2"/>
    <dbReference type="STRING" id="300267.SDY_4295"/>
    <dbReference type="EnsemblBacteria" id="ABB64193">
        <property type="protein sequence ID" value="ABB64193"/>
        <property type="gene ID" value="SDY_4295"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4295"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5063"/>
    <dbReference type="HOGENOM" id="CLU_013016_1_0_6"/>
    <dbReference type="OMA" id="GAPCFVW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="331" mass="34780" checksum="5EFD9E2C0EB352F2" modified="2005-12-06" version="1">MTAIKHPVLLWGLPVAALIIFWLSLFCYSAIPVSGADATRALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSALSPTPIAGYSLSFIAACGGGVSWLLVMTAGGGFRHTHDRNKLILAGIALSAFCMGLTRITLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q328T4</accession>
    <name>Q328T4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjgK</name>
        <name evidence="1" type="ordered locus">SDY_4270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405662.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328T4"/>
    <dbReference type="STRING" id="300267.SDY_4270"/>
    <dbReference type="EnsemblBacteria" id="ABB64171">
        <property type="protein sequence ID" value="ABB64171"/>
        <property type="gene ID" value="SDY_4270"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4270"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5031"/>
    <dbReference type="HOGENOM" id="CLU_107139_3_0_6"/>
    <dbReference type="OMA" id="CLIKVLM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004375">
        <property type="entry name" value="NanQ/TabA/YiaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037012">
        <property type="entry name" value="NanQ/TabA/YiaL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34986">
        <property type="entry name" value="PTHR34986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04074">
        <property type="entry name" value="DUF386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00022">
        <property type="entry name" value="TIGR00022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="153" mass="17312" checksum="2B5E648051B2FB80" modified="2005-12-06" version="1">MEKMIIGNIHNLQPWLPQELRQAIEHIKAHVTAETPKGKHDIEGNRLFYLISEDMTEPYEARRAEYHARYLDIQIVLKGQEGMTFSTQPAGTPDTDWLADKDIAFLPEGVDEKTVILNEGDFVVFYPGEVHKPLCAVGAPARVRKAVVKMLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Z1</accession>
    <name>Q328Z1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RhsA protein in rhs element</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">RhsB protein in rhs element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rhsA</name>
        <name evidence="4" type="synonym">rhsB</name>
        <name evidence="4" type="ordered locus">SDY_3800</name>
        <name evidence="5" type="ordered locus">SDY_4210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RHS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000014997.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405236.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405605.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_3800"/>
    <dbReference type="EnsemblBacteria" id="ABB63745">
        <property type="protein sequence ID" value="ABB63745"/>
        <property type="gene ID" value="SDY_3800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64114">
        <property type="protein sequence ID" value="ABB64114"/>
        <property type="gene ID" value="SDY_4210"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3800"/>
    <dbReference type="KEGG" id="sdy:SDY_4210"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4490"/>
    <dbReference type="HOGENOM" id="CLU_001218_0_1_6"/>
    <dbReference type="OMA" id="CEDIANS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001826">
        <property type="entry name" value="RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03527">
        <property type="entry name" value="RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00394">
        <property type="entry name" value="RHSPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="3">
        <location>
            <begin position="46"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1213" mass="137249" checksum="37957E9FC45E213C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q329A2</accession>
    <name>Q329A2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yieH</name>
        <name evidence="2" type="ordered locus">SDY_4198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000078076.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405594.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329A2"/>
    <dbReference type="STRING" id="300267.SDY_4198"/>
    <dbReference type="EnsemblBacteria" id="ABB64103">
        <property type="protein sequence ID" value="ABB64103"/>
        <property type="gene ID" value="SDY_4198"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4198"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4937"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_2_6"/>
    <dbReference type="OMA" id="MDVYGFT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="221" mass="24783" checksum="ADAC45D5187D640F" modified="2005-12-06" version="1">MSQIEAVFFDCDGTLVDSEVICSRAYVTMFREFSIHVDLKEIFTRFKGVKLYEIIDIISKEQGVTMVQADAEHVYRAEVARLFDTELEDIAGANELLASINVPMCVVSNGPVSKMQHSLGKLNMLHYFPGKLFSGYDIQRWKPDPALMFHAAKAMNVNVENCILVDDSSAGAQSGIDAGMEVFYFCADPHNKPIVHPKVTTFTEQAQLPALWKARGWNITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q329K5</accession>
    <name>Q329K5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (guanosine(18)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA [Gm18] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">spoU</name>
        <name evidence="4" type="synonym">trmH</name>
        <name evidence="7" type="ordered locus">SDY_4083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001070172.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405491.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329K5"/>
    <dbReference type="STRING" id="300267.SDY_4083"/>
    <dbReference type="EnsemblBacteria" id="ABB64000">
        <property type="protein sequence ID" value="ABB64000"/>
        <property type="gene ID" value="SDY_4083"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4083"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4804"/>
    <dbReference type="HOGENOM" id="CLU_021322_4_2_6"/>
    <dbReference type="OMA" id="TDRYQHV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009020">
        <property type="term" value="F:tRNA (guanosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052665">
        <property type="term" value="F:tRNA (uracil-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002938">
        <property type="term" value="P:tRNA guanine ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18092">
        <property type="entry name" value="SpoU-like_TrmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02060">
        <property type="entry name" value="tRNA_methyltr_TrmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022724">
        <property type="entry name" value="rRNA_MeTrfase_SpoU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033671">
        <property type="entry name" value="TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43453">
        <property type="entry name" value="PTHR43453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12105">
        <property type="entry name" value="SpoU_methylas_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SpoU_methylas_C" evidence="6">
        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="229" mass="25325" checksum="180BE659A5AC07CF" modified="2005-12-06" version="1">MNPTRYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGSRMRTMASAAAGSNSWVQVKTHRTIGDAVAHLKGQGMQILATHLSDNAVDFREIDYTRPTCILMGQEKTGITEEALALADQDIIIPMIGMVQSLNVSVASALILYEAQHQRQNAGMYLRENSMLPEAEQQRLLFEGGYPVLAKVAKRKGLPYPHVNQQGEIEADADWWATMQAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q329M9</accession>
    <name>Q329M9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide 1,2-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfaJ</name>
        <name evidence="2" type="ordered locus">SDY_4058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001001732.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405467.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329M9"/>
    <dbReference type="STRING" id="300267.SDY_4058"/>
    <dbReference type="CAZy" id="GT8">
        <property type="family name" value="Glycosyltransferase Family 8"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63976">
        <property type="protein sequence ID" value="ABB63976"/>
        <property type="gene ID" value="SDY_4058"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4058"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4774"/>
    <dbReference type="HOGENOM" id="CLU_050833_5_0_6"/>
    <dbReference type="OMA" id="YMNEICE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008918">
        <property type="term" value="F:lipopolysaccharide 3-alpha-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013645">
        <property type="entry name" value="Glyco_transf_8N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08437">
        <property type="entry name" value="Glyco_transf_8C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_8C" evidence="1">
        <location>
            <begin position="275"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="331" mass="38504" checksum="61A2B3AA93A207ED" modified="2005-12-06" version="1">MNEFIKERFSYLADNKKENAPELNVSYGIDKNFLYGTGVSISSVLINNSDINFVFHVFTDYVDDDYLKSFNKTAKQFNTSIIVYLIDPKYFADLPTSQFWSYATYFRVLSFEYLSESISTLLYLDADVVCKGSLKPLTEIIFKDEFAAVIPDNDSTQAACAKRLNIPEMNGRYFNAGVIYVNLKKWHEANLTPYLLKLLRGETKYGSLKYLDQDALNIAFNMNNIYLAKDFDTIYTLKNELHDRSHRKFQKTITDKTVLIHYTGITKPWHSWAGYPSASYFNIAREQSPWKKYPLKEARTVAEMQKQYKHLFAHGEYIKGITSLIKYKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Q6</accession>
    <name>Q329Q6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2900</name>
        <name evidence="4" type="ordered locus">SDY_4031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62930">
        <property type="protein sequence ID" value="ABB62930"/>
        <property type="gene ID" value="SDY_2900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63949">
        <property type="protein sequence ID" value="ABB63949"/>
        <property type="gene ID" value="SDY_4031"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2900"/>
    <dbReference type="KEGG" id="sdy:SDY_4031"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="13074" checksum="AC32D2047ACB10EB" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q329R5</accession>
    <name>Q329R5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pstS</name>
        <name evidence="9" type="ordered locus">SDY_4022</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000867141.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405431.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329R5"/>
    <dbReference type="STRING" id="300267.SDY_4022"/>
    <dbReference type="EnsemblBacteria" id="ABB63940">
        <property type="protein sequence ID" value="ABB63940"/>
        <property type="gene ID" value="SDY_4022"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4022"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4736"/>
    <dbReference type="HOGENOM" id="CLU_034528_1_0_6"/>
    <dbReference type="OMA" id="FPYPVYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220835" description="Phosphate-binding protein PstS" evidence="7">
        <location>
            <begin position="26"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="8">
        <location>
            <begin position="27"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="346" mass="37068" checksum="F49D490C0E37BD9A" modified="2005-12-06" version="1">MKVMRTTVATVVAATLSMSAFSVFAEASLTGAGATFPAPVYAKWADTYQKETGNKVNYQGIGSSGGVKQIIANTVDFGASDAPLSDEKLAQEGLFQFPTVIGGVVLAVNIPGLKSGELVLDGKTLGDIYLGKIKKWDDEAIAKLNPGLKLPSQNIAVVRRADGSGTSFVFTSYLAKVNEEWKNNVGTGSTVKWPIGLGGKGNDGIAAFVQRLLGAIGYVEYAYAKQNNLAYTKLISADGKPVSPTEENFANVAKGADWSKTFAQDLTNQKGEDAWPITSTTFILIHKDQKKPEQGTEVLKFFDWAYKTGAKQANDLDYASLPDSVVEQVRAAWKTNIKDSSGKPLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A18</accession>
    <name>UBID_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-octaprenyl-4-hydroxybenzoate carboxy-lyase</fullName>
            <ecNumber evidence="1">4.1.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polyprenyl p-hydroxybenzoate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiD</name>
        <name type="ordered locus">SDY_3902</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:41680"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9516"/>
            <dbReference type="ChEBI" id="CHEBI:1269"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="4.1.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN (prenyl-FMN) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.98" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000382918.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405328.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A18"/>
    <dbReference type="SMR" id="Q32A18"/>
    <dbReference type="STRING" id="300267.SDY_3902"/>
    <dbReference type="EnsemblBacteria" id="ABB63837">
        <property type="protein sequence ID" value="ABB63837"/>
        <property type="gene ID" value="SDY_3902"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3902"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4610"/>
    <dbReference type="HOGENOM" id="CLU_023348_4_1_6"/>
    <dbReference type="OMA" id="SYQQFWG"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008694">
        <property type="term" value="F:3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01636">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023677">
        <property type="entry name" value="UbiD_bacteria"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="chain" id="PRO_0000267700" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase">
        <location>
            <begin position="1"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="197"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01636"/>
        </source>
    </evidence>
    <sequence length="497" mass="55682" checksum="A1C6EB7DA5DC22FC" modified="2005-12-06" version="1">MDVMKYNDLRDFLTLLEQQGELKRITLPVDPHLEITEIADRTLRAGGPALLFENPKGYSMPVLCNLFGTPKRVAMGMGQEDVSALREVGKLLAFLKEPEPPKGFRDLFDKLPQFKQVLNMPTKRLRGAPCQQKIVSGDDVDLHRIPIMTCWPGDAAPLITWGLTVTRRPHKERQNLGIYRQQLIGKNKLIMRWLSHRGGALDYQEWCAAHPGERFPVSVALGADPATILGAVTPVPDTLSEYAFAGLLRGTKTEVVKCISNDLEVPASAEIVLEGYIEQGETAPEGPYGDHTGYYNEVDSFPVFTVTHITQREDAIYHSTYTGRPPDEPAVLGVALNEVFVPILQKQFPEIVDFYLPPEGCSYRLAVVTIKKQYAGHAKRVMMGVWSFLRQFMYTKFVIVCDDDVNARDWNDVIWAITTRMDPARDTVLVENTPIDYLDFASPVSGLGSKMGLDATNKWPGETQREWGRPIKKDPDVVAHIDAIWDELAIFNNGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A35</accession>
    <name>Q32A35_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">DNA polymerase I</fullName>
            <ecNumber evidence="3 13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">polA</name>
        <name evidence="17" type="ordered locus">SDY_3879</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Single-chain monomer with multiple functions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3 13"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000250039.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405311.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A35"/>
    <dbReference type="SMR" id="Q32A35"/>
    <dbReference type="STRING" id="300267.SDY_3879"/>
    <dbReference type="EnsemblBacteria" id="ABB63820">
        <property type="protein sequence ID" value="ABB63820"/>
        <property type="gene ID" value="SDY_3879"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3879"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4589"/>
    <dbReference type="HOGENOM" id="CLU_004675_0_1_6"/>
    <dbReference type="OMA" id="NRPPMPD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="15">
        <location>
            <begin position="7"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="14">
        <location>
            <begin position="330"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="16">
        <location>
            <begin position="686"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB63820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="928" mass="103147" checksum="C43D0DBB9E6A395C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A36</accession>
    <name>ENGB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">engB</name>
        <name type="ordered locus">SDY_3878</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63819" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63819.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000183349.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405310.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A36"/>
    <dbReference type="SMR" id="Q32A36"/>
    <dbReference type="STRING" id="300267.SDY_3878"/>
    <dbReference type="EnsemblBacteria" id="ABB63819">
        <property type="protein sequence ID" value="ABB63819"/>
        <property type="gene ID" value="SDY_3878"/>
    </dbReference>
    <dbReference type="GeneID" id="66672230"/>
    <dbReference type="KEGG" id="sdy:SDY_3878"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4588"/>
    <dbReference type="HOGENOM" id="CLU_033732_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000266948" description="Probable GTP-binding protein EngB">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="EngB-type G" evidence="1">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="78"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="210" mass="23561" checksum="11BCA2ED59220C0D" modified="2006-12-12" version="2">MTNLNYQQTHFVMSAPDIRHLPSDTGIEVAFAGRSNAGKSSALNTLTNQKSLARTSKTPGRTQLINLFEVADGKRLVDLPGYGYAEVPEEMKRKWQRALGEYLEKRQSLQGLVVLMDIRHPLKDLDQQMIEWAVDSNIAVLVLLTKADKLASGARKAQLNMVREAVLAFNGDVQVETFSSLKKQGVDKLRQKLDTWFSEMQPVEETQDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A90</accession>
    <name>Q32A90_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavodoxin/ferredoxin--NADP reductase</fullName>
            <ecNumber evidence="6">1.18.1.2</ecNumber>
            <ecNumber evidence="5">1.19.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ferredoxin (flavodoxin):NADP(+) oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ferredoxin--NADP reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Flavodoxin--NADP reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fpr</name>
        <name evidence="13" type="ordered locus">SDY_3820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + reduced [flavodoxin] = 2 H(+) + NADPH + oxidized [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:50756"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.19.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="6"/>
    <dbReference type="EC" id="1.19.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000796320.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405256.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A90"/>
    <dbReference type="SMR" id="Q32A90"/>
    <dbReference type="STRING" id="300267.SDY_3820"/>
    <dbReference type="EnsemblBacteria" id="ABB63765">
        <property type="protein sequence ID" value="ABB63765"/>
        <property type="gene ID" value="SDY_3820"/>
    </dbReference>
    <dbReference type="GeneID" id="66672168"/>
    <dbReference type="KEGG" id="sdy:SDY_3820"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4511"/>
    <dbReference type="HOGENOM" id="CLU_003827_3_0_6"/>
    <dbReference type="OMA" id="MTSEHYW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06195">
        <property type="entry name" value="FNR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033892">
        <property type="entry name" value="FNR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="248" mass="27699" checksum="1D71D26F195EA512" modified="2005-12-06" version="1">MADWVTGKVTKVQNWTDALFSLTVHAPVLPFTAGQFTKLGLEIDGERVQRAYSYVNSPDNPDLEFYLVTVPDGKLSPRLAALKPGDEVQVVSEAAGFFVLDEVPDCETLWMLATGTAIGPYLSILQLGKDLDRFKNLVLVHAARYAADLSYLPLMQELEKRYEGKLRIQTVVSRETAAGSLTGRIPALIESGELESAIGLPMNKETSHVMLCGNPQMVRDTQQLLKETRQMTKHLRRRPGHMTAEHYW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AB9</accession>
    <name>CAPP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="1">PEPC</shortName>
            <shortName evidence="1">PEPCase</shortName>
            <ecNumber evidence="1">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppc</name>
        <name type="ordered locus">SDY_3791</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001005574.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405227.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AB9"/>
    <dbReference type="SMR" id="Q32AB9"/>
    <dbReference type="STRING" id="300267.SDY_3791"/>
    <dbReference type="EnsemblBacteria" id="ABB63736">
        <property type="protein sequence ID" value="ABB63736"/>
        <property type="gene ID" value="SDY_3791"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3791"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4480"/>
    <dbReference type="HOGENOM" id="CLU_006557_2_0_6"/>
    <dbReference type="OMA" id="PWVFGWT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000025589" description="Phosphoenolpyruvate carboxylase">
        <location>
            <begin position="1"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <sequence length="883" mass="99093" checksum="466E1EE722AB50C5" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AI2</accession>
    <name>Q32AI2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AI2"/>
    <dbReference type="STRING" id="300267.SDY_3713"/>
    <dbReference type="EnsemblBacteria" id="ABB63673">
        <property type="protein sequence ID" value="ABB63673"/>
        <property type="gene ID" value="SDY_3713"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3713"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="73" mass="7866" checksum="592725651922A8E1" modified="2005-12-06" version="1">MSRKTQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGTLGQWVTAARKGLGTPGSRTVAELESEILGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AL1</accession>
    <name>Q32AL1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yrfG</name>
        <name evidence="2" type="ordered locus">SDY_3679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405135.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AL1"/>
    <dbReference type="STRING" id="300267.SDY_3679"/>
    <dbReference type="EnsemblBacteria" id="ABB63644">
        <property type="protein sequence ID" value="ABB63644"/>
        <property type="gene ID" value="SDY_3679"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3679"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4366"/>
    <dbReference type="HOGENOM" id="CLU_106706_0_0_6"/>
    <dbReference type="OMA" id="HDYGFPK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27092" checksum="E835D11A02528526" modified="2005-12-06" version="1">MLPCRANCFTLEISLMHINIAWQDVDTVLLDMDGTLLDLAFDNYFWQKLVPETWGAKNGVTPQEAMEYMRQQYHDVQHTLNWYCLDYWSEQLGLDICAMTTEMGPRAVLREDTIPFLEALKASGKQRILLTNAHPHNLAVKLEHTGLDAHLDLLLSTHTFGYPKEDQRLWHAVAEATGLKAERTLFIDDSEAILDAAAQFGIRYCLGVTNPDSGIAEKQYQRHPSLNDYRRLIPSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AV2</accession>
    <name>Q32AV2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 13">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="13">ASA dehydrogenase</shortName>
            <shortName evidence="13">ASADH</shortName>
            <ecNumber evidence="8 13">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">asd</name>
        <name evidence="15" type="ordered locus">SDY_3579</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="8 13"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000799963.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405044.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AV2"/>
    <dbReference type="SMR" id="Q32AV2"/>
    <dbReference type="STRING" id="300267.SDY_3579"/>
    <dbReference type="EnsemblBacteria" id="ABB63553">
        <property type="protein sequence ID" value="ABB63553"/>
        <property type="gene ID" value="SDY_3579"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3579"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4250"/>
    <dbReference type="HOGENOM" id="CLU_066397_0_0_6"/>
    <dbReference type="OMA" id="MFDVPDE"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011534">
        <property type="entry name" value="Asp_ADH_gamma-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46278:SF4">
        <property type="entry name" value="PTHR46278:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01745">
        <property type="entry name" value="asd_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="14">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB63553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="367" mass="39960" checksum="C53D4DE6EA7CC298" modified="2005-12-06" version="1">MKNVGFIGWRGMVGSVLMQRMVEERDFDAIRPVFFSTSQLGQAAPSFGGTTGTLQDAFDLEALKALDIIVTCQGGDYTNEIYPKLRESGWQGYWIDAASSLRMKDDAIIILDPVNQDVITGGLNNGIRTFVGGNCTVSLMLMSLGGLFANDLVDWVSVATYQAASGGGARHMRELLTQMGHLYGHVADELATPSSAILDIERKVTTLTRSGELPVDNFGVPLAGSLIPWIDKQLDNGQSREEWKGQAETNKILNTSSVIPVDGLCVRVGALRCHSQAFTIKLKKDVSIPTVEELLAAHNPWAKVVPNDREITMRELTPAAVTGTLTTPVGRLRKLNMGPEFLSAFTVGDQLLWGAAEPLRRMLRQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AY8</accession>
    <name>Q32AY8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_3541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405008.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AY8"/>
    <dbReference type="EnsemblBacteria" id="ABB63517">
        <property type="protein sequence ID" value="ABB63517"/>
        <property type="gene ID" value="SDY_3541"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3541"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4201"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="AYLSAEC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14930" checksum="E1B3BB010C754B56" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISQRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B34</accession>
    <name>RL2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplB</name>
        <name type="ordered locus">SDY_3493</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000741730.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404962.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B34"/>
    <dbReference type="SMR" id="Q32B34"/>
    <dbReference type="STRING" id="300267.SDY_3493"/>
    <dbReference type="EnsemblBacteria" id="ABB63471">
        <property type="protein sequence ID" value="ABB63471"/>
        <property type="gene ID" value="SDY_3493"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3493"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4146"/>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_6"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000237241" description="50S ribosomal protein L2">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="273" mass="29832" checksum="4E00B32EEFC68F61" modified="2005-12-06" version="1">MAAVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B98</accession>
    <name>AAEA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">p-hydroxybenzoic acid efflux pump subunit AaeA</fullName>
            <shortName evidence="1">pHBA efflux pump protein A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aaeA</name>
        <name type="ordered locus">SDY_3417</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms an efflux pump with AaeB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000854033.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404898.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B98"/>
    <dbReference type="SMR" id="Q32B98"/>
    <dbReference type="STRING" id="300267.SDY_3417"/>
    <dbReference type="EnsemblBacteria" id="ABB63407">
        <property type="protein sequence ID" value="ABB63407"/>
        <property type="gene ID" value="SDY_3417"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3417"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4075"/>
    <dbReference type="HOGENOM" id="CLU_018816_15_2_6"/>
    <dbReference type="OMA" id="EVEPTFN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01544">
        <property type="entry name" value="AaeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022871">
        <property type="entry name" value="PHBA_efflux_pump_AaeA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000300555" description="p-hydroxybenzoic acid efflux pump subunit AaeA">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01544"/>
        </source>
    </evidence>
    <sequence length="310" mass="34761" checksum="BA6F840F325B6F23" modified="2005-12-06" version="1">MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQVNVHDNQLVKKGQVLFTIDQPRYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPADGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTRDDKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFRKMAHRLREFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BB6</accession>
    <name>NANE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="1">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nanE</name>
        <name type="ordered locus">SDY_3398</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NanE family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001308081.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404880.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BB6"/>
    <dbReference type="SMR" id="Q32BB6"/>
    <dbReference type="STRING" id="300267.SDY_3398"/>
    <dbReference type="EnsemblBacteria" id="ABB63389">
        <property type="protein sequence ID" value="ABB63389"/>
        <property type="gene ID" value="SDY_3398"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3398"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4054"/>
    <dbReference type="HOGENOM" id="CLU_086300_0_0_6"/>
    <dbReference type="OMA" id="TRPMEIT"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000301481" description="Putative N-acetylmannosamine-6-phosphate 2-epimerase">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <sequence length="229" mass="24145" checksum="DAF586F4390DB8C4" modified="2005-12-06" version="1">MSLLAQLDQKIAANGGLIVSCQPVPDSPLDKPDIVAAMALAAEQAGAVAIRIEGVANLQATRAVVSVPIIGIVKRDLEDSPVRITAYIEDVDALAQAGADIIAIDGTDRPRPVPVETLLARIHHHGLLAMTDCSTPEDGLACQKLGAEIIGTTLSGYTTPETPEEPDLTLVKRLSDAGCRVIAEGRYNTPAQAADAMRHGAWAVTVGSAITRLEHICQWYNTAMKKAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BC0</accession>
    <name>Q32BC0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gltD</name>
        <name evidence="2" type="ordered locus">SDY_3394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000081686.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404876.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BC0"/>
    <dbReference type="STRING" id="300267.SDY_3394"/>
    <dbReference type="EnsemblBacteria" id="ABB63385">
        <property type="protein sequence ID" value="ABB63385"/>
        <property type="gene ID" value="SDY_3394"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3394"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4050"/>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_6"/>
    <dbReference type="OMA" id="IDYGRCS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006006">
        <property type="entry name" value="GltD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42783:SF1">
        <property type="entry name" value="PTHR42783:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01318">
        <property type="entry name" value="gltD_gamma_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="472" mass="51981" checksum="A9365900E2F5340D" modified="2005-12-06" version="1">MSQNVYQFIDLQRVDPPKKPLKIRKIEFVEIYEPFSEGQAKAQADRCLSCGNPYCEWKCPVHNYIPNWLKLANEGRIFEAAELSHQTNTLPEVCGRVCPQDRLCEGSCTLNDEFGAVTIGNIERYINDKAFEMGWRPDMSGVKQTGKKVAIIGAGPAGLACADVLTRNGVKAVVFDRHPEIGGLLTFGIPAFKLEKEVMTRRREIFTGMGIEFKLNTEVGRDVQLDDLLSDYNAVFLGVGTYQSMRGGLENEDADGVYAALPFLIANTKQLMGFGETREEPFVSMEGKRVVVLGGGDTAMDCVRTSVRQGAKHVTCAYRRDEENMPGSRREVKNAREEGVEFKFNVQPLGIKVNGNGKVSGVKMVRTEMGEPDAKGRRRAEIVAGSEHIVPADAVIMAFGFRPHSMEWLAKHSVELDSQGRIIAPEGSDNAFQTSNPKIFAGGDIVRGSDLVVTAIAEGHKAADGIMNWLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BH4</accession>
    <name>Q32BH4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone biosynthesis protein UbiV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhbV</name>
        <name evidence="1" type="synonym">ubiV</name>
        <name evidence="2" type="ordered locus">SDY_3338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms an heterodimer with UbiU.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U32 family. UbiV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404822.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BH4"/>
    <dbReference type="STRING" id="300267.SDY_3338"/>
    <dbReference type="MEROPS" id="U32.A01"/>
    <dbReference type="EnsemblBacteria" id="ABB63331">
        <property type="protein sequence ID" value="ABB63331"/>
        <property type="gene ID" value="SDY_3338"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3338"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3992"/>
    <dbReference type="HOGENOM" id="CLU_056172_0_0_6"/>
    <dbReference type="OMA" id="CCIKYPT"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02233">
        <property type="entry name" value="UbiV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043693">
        <property type="entry name" value="UbiV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="298" mass="33192" checksum="671EF53407233EA8" modified="2005-12-06" version="1">MAVRKAMKYSLGPVLWYWPKETLEEFYQQAATSSADVIYLGEAVCSKRRATKVGDWLEMAKSLAGSGKQIVLSTLALVQASSELGELKRYVENGEFLIEASDLGVVNMCAERKLPFVAGHALNCYNAVTLKILLKQGMMRWCMPVELSRDWLVNLLNQCDELGIRNQFEVEVLSYGHLPLAYSARCFTARSEDRPKDECETCCIKYPNGRNVLSQENQQVFVLNGIQTMSGYVYNLGNELASMQGLVDVVRLSPQGTDTFAMLDAFRANENGAAPLPLTANSDCNGYWRRLAGLELQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BJ9</accession>
    <name>Q32BJ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional activator of tdc operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tdcA</name>
        <name evidence="3" type="ordered locus">SDY_3310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000104211.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404797.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BJ9"/>
    <dbReference type="SMR" id="Q32BJ9"/>
    <dbReference type="STRING" id="300267.SDY_3310"/>
    <dbReference type="EnsemblBacteria" id="ABB63306">
        <property type="protein sequence ID" value="ABB63306"/>
        <property type="gene ID" value="SDY_3310"/>
    </dbReference>
    <dbReference type="GeneID" id="66672981"/>
    <dbReference type="KEGG" id="sdy:SDY_3310"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3956"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_0_6"/>
    <dbReference type="OMA" id="PQTDMGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="312" mass="34539" checksum="1ADD366D71ED68AB" modified="2005-12-06" version="1">MSTILLPKTQHLVVFQEVIRSGSIGSAAKELGLTQPAVSKIINDIEDYFGVELVVRKNTGVTLTPAGQLLLSRSESITREMKNMVNEISGMSSEAVVEVSFGFPSLIGFTFMSGMINKFKEVFPKAQVSMYEAQLSSFLPAIRDGRLDFAIGTLSAEMKLQDLHVEPLFESEFVLVASKSRTCTGTTTLESLKNEQWVLPQTNMGYYSELLTTLQRNGISIENIVKTDSVVTIYNLVLNADFLTVIPCDMTSPFGSNQFITIPVEETLPVAQYAAVWSKNYRIKKAASVLVELAKEYSSYNGCRRRQLIEVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BW4</accession>
    <name>AC4CH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N(4)-acetylcytidine amidohydrolase</fullName>
            <shortName evidence="2">ac4C amidohydrolase</shortName>
            <ecNumber evidence="2">3.5.1.135</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">yqfB</name>
        <name type="ordered locus">SDY_3181</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N(4)-acetylcytidine = acetate + cytidine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62932"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:70989"/>
            <dbReference type="EC" id="3.5.1.135"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:146133"/>
            <dbReference type="EC" id="3.5.1.135"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N(4)-acetylcytosine = acetate + cytosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:146134"/>
            <dbReference type="EC" id="3.5.1.135"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)-acetylcytidine amidohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.135" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001182957.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404682.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BW4"/>
    <dbReference type="SMR" id="Q32BW4"/>
    <dbReference type="STRING" id="300267.SDY_3181"/>
    <dbReference type="EnsemblBacteria" id="ABB63191">
        <property type="protein sequence ID" value="ABB63191"/>
        <property type="gene ID" value="SDY_3181"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3181"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3801"/>
    <dbReference type="HOGENOM" id="CLU_152586_0_0_6"/>
    <dbReference type="OMA" id="HARQENM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106251">
        <property type="term" value="F:N4-acetylcytidine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00684">
        <property type="entry name" value="ac4C_amidohydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008314">
        <property type="entry name" value="AC4CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38088">
        <property type="entry name" value="PTHR38088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029143">
        <property type="entry name" value="UCP029143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000044961" description="N(4)-acetylcytidine amidohydrolase">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00684"/>
        </source>
    </evidence>
    <sequence length="103" mass="11905" checksum="BBC4E2AA87D6F2CE" modified="2005-12-06" version="1">MQPNDITFFQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELKKVIADIYPGQTQFYVIEFKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BW8</accession>
    <name>Q32BW8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">visC</name>
        <name evidence="9" type="ordered locus">SDY_3175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001192224.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404678.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BW8"/>
    <dbReference type="STRING" id="300267.SDY_3175"/>
    <dbReference type="EnsemblBacteria" id="ABB63187">
        <property type="protein sequence ID" value="ABB63187"/>
        <property type="gene ID" value="SDY_3175"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3175"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3793"/>
    <dbReference type="HOGENOM" id="CLU_009665_8_3_6"/>
    <dbReference type="OMA" id="SDVACII"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="8">
        <location>
            <begin position="4"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="400" mass="44205" checksum="C08DC1194BFCBFF6" modified="2005-12-06" version="1">MQSVDVAIVGGGMVGLAVACGLQGSGLRVAVLEQRVPEPLAVDAPPQLRVSAINAASEKLLTRLGVWQDILSRRASCYHGMEVWDKDSFGHISFDDQSMGYSHLGHIVENSVSHYALWNKAQQSSDITLLAPAELQQVAWGENETFLTLKDGSMLTARLVIGADGANSWLRNKADIPLTFWDYQHHALVATIRTEEPHDAVVRQVFHGEGILAFLPLSDPHLCSIVWSLSPEEAQRMQQAGEDEFNRALNIAFDNRLGLCKVESERQVFPLTGRYARQFAAHRLALVGDAAHTIHPLAGQGVNLGFMDAAELIAELKRLHRQGKDIGQYIYLRRYERSRKHSAALMLAGMQGFRDLFSGTNPAKKLLRDIGLKLADTLPGVKPQLIRQAMGLNDLPEWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C57</accession>
    <name>Q32C57_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HybF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">hybF</name>
        <name evidence="5" type="ordered locus">SDY_3082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family. HybF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000544959.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404589.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C57"/>
    <dbReference type="STRING" id="300267.SDY_3082"/>
    <dbReference type="EnsemblBacteria" id="ABB63098">
        <property type="protein sequence ID" value="ABB63098"/>
        <property type="gene ID" value="SDY_3082"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3082"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3689"/>
    <dbReference type="HOGENOM" id="CLU_126929_0_0_6"/>
    <dbReference type="OMA" id="ILLCPCG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02099">
        <property type="entry name" value="HybF_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039002">
        <property type="entry name" value="HybF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020538">
        <property type="entry name" value="Hydgase_Ni_incorp_HypA/HybF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00100">
        <property type="entry name" value="hypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01249">
        <property type="entry name" value="HYPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="113" mass="12625" checksum="72191648C844ABE6" modified="2005-12-06" version="1">MHELSLCQSAVEIIQRQAEQHDVKRVTAVWLEIGALSCVEGSAVRFSFEIVCHGTVAQGCDLHIVYKPAQAWCWDCSQVVEIHQHDAQCPLCHGERLRVDTGDSLIVKSIEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CJ1</accession>
    <name>Q32CJ1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable UbiX-like flavin prenyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phenolic acid decarboxylase subunit B</fullName>
            <shortName evidence="5">PAD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_2938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives. Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family. YclB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000767723.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404455.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CJ1"/>
    <dbReference type="STRING" id="300267.SDY_2938"/>
    <dbReference type="EnsemblBacteria" id="ABB62964">
        <property type="protein sequence ID" value="ABB62964"/>
        <property type="gene ID" value="SDY_2938"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2938"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3530"/>
    <dbReference type="HOGENOM" id="CLU_074522_0_1_6"/>
    <dbReference type="OMA" id="FERWNGW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01986">
        <property type="entry name" value="ubiX_pad_yclB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032901">
        <property type="entry name" value="UbiX_pad_YclB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="197" mass="21444" checksum="447F88415C03428F" modified="2005-12-06" version="1">MKLIVGMTGATGAPLGVALLQALREMPNVETHLVMSKWAKTTIELETPYSARDVAALADFSHNPADQAATISSGSFRTDGMIVIPCSMKTLAGIRAGYADGLVGRAADVVLKEGRKLVLVPREMPLSTIHLENMLALSRMGVAMVPPMPAFYNHPETVDDIVHHVVARVLDQFGLEHPHARRWQGLPQARNFSQENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CP9</accession>
    <name>Q32CP9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nrdF</name>
        <name evidence="7" type="ordered locus">SDY_2869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="4 6">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000777979.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404397.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CP9"/>
    <dbReference type="STRING" id="300267.SDY_2869"/>
    <dbReference type="EnsemblBacteria" id="ABB62906">
        <property type="protein sequence ID" value="ABB62906"/>
        <property type="gene ID" value="SDY_2869"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2869"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3448"/>
    <dbReference type="HOGENOM" id="CLU_052495_0_0_6"/>
    <dbReference type="OMA" id="IGYKYQR"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026494">
        <property type="entry name" value="RNR_NrdF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04171">
        <property type="entry name" value="RNR_1b_NrdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="322" mass="36807" checksum="AD34C551E29D3D7A" modified="2005-12-06" version="1">MKLSRISAINWNKISDDKDLEVWNRLTSNFWLPEKVPLSNDIPAWQTLTVVEQQLTMRVFTGLTLLDTLQNVIGAPSLMPDALTPHEEAVLSNISFMEVVHARSYSSIFSTLCQTKDVDAAYAWSEENALLQRKAQIIQQHYRGDNPLKKKIASVFLESFLFYSGFWLPMYFSSRGKLTNTADLIRLIIRDEAVHGYYIGYKYQKSLEKISEAQREELKSFAFDLLLELYDNELQYTDELYAETPWADDVKTFLCYNANKALMNLGYEPLFPAEMAEVNPAILAALSPNADENHDFFSGSSSSYVMGKAVETEDEEVMTLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CX0</accession>
    <name>Q32CX0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide_cyc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_2792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribosome association toxin RatA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000600190.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404326.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CX0"/>
    <dbReference type="SMR" id="Q32CX0"/>
    <dbReference type="STRING" id="300267.SDY_2792"/>
    <dbReference type="EnsemblBacteria" id="ABB62835">
        <property type="protein sequence ID" value="ABB62835"/>
        <property type="gene ID" value="SDY_2792"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2792"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3364"/>
    <dbReference type="HOGENOM" id="CLU_079653_3_1_6"/>
    <dbReference type="OMA" id="YIDGPFK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="PTHR12901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="3">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="158" mass="17743" checksum="68BDA91BE6AC83D5" modified="2005-12-06" version="1">MILFVGFLLMEIVMPQISRTALVPYSAEQMYQLVNDVQSYPQFLPGCTGSRILESTPGQMTAAVDVSKAGISKTFTTRNQLTSNQSILMNLVDGPFKKLIGGWKFTPLSQEACRIEFHLDFEFTNKLIELAFGRVFKELASNMVQAFTVRAKEVYSAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-06-13" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CX2</accession>
    <name>BAME_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Outer membrane protein assembly factor BamE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bamE</name>
        <name type="synonym">smpA</name>
        <name type="ordered locus">SDY_2790</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BamE family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB62833" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62833.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001203437.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404324.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CX2"/>
    <dbReference type="BMRB" id="Q32CX2"/>
    <dbReference type="SMR" id="Q32CX2"/>
    <dbReference type="STRING" id="300267.SDY_2790"/>
    <dbReference type="EnsemblBacteria" id="ABB62833">
        <property type="protein sequence ID" value="ABB62833"/>
        <property type="gene ID" value="SDY_2790"/>
    </dbReference>
    <dbReference type="GeneID" id="66673495"/>
    <dbReference type="KEGG" id="sdy:SDY_2790"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3362"/>
    <dbReference type="HOGENOM" id="CLU_083835_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00925">
        <property type="entry name" value="OM_assembly_BamE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026592">
        <property type="entry name" value="BamE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037873">
        <property type="entry name" value="BamE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007450">
        <property type="entry name" value="Lipoprotein_SmpA/OmlA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37482">
        <property type="entry name" value="PTHR37482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04355">
        <property type="entry name" value="SmpA_OmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000417870" description="Outer membrane protein assembly factor BamE">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="113" mass="12302" checksum="CFD8840C014AA0A2" modified="2012-06-13" version="2" precursor="true">MRCKTLTAAAAVLLMLTAGCSTLERVVYRPDINQGNYLTANDVSKIRVGMTQQQVAYALGTPLMSDPFGTNTWFYVFRQQPGHEGVTQQTLTLTFNSSGVLTNIDNKPALSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CY5</accession>
    <name>Q32CY5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404311.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CY5"/>
    <dbReference type="STRING" id="300267.SDY_2777"/>
    <dbReference type="EnsemblBacteria" id="ABB62820">
        <property type="protein sequence ID" value="ABB62820"/>
        <property type="gene ID" value="SDY_2777"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2777"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3347"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025293">
        <property type="entry name" value="YfiR/HmsC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13689">
        <property type="entry name" value="DUF4154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="102" mass="11208" checksum="325D4FBF55EA7C0A" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITTECIIGSAFCLIIHNNDVRFAVNLDALSRSGVKVNPDVLMLARKKNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D29</accession>
    <name>Q32D29_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">csiE</name>
        <name evidence="2" type="ordered locus">SDY_2731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D29"/>
    <dbReference type="STRING" id="300267.SDY_2731"/>
    <dbReference type="EnsemblBacteria" id="ABB62776">
        <property type="protein sequence ID" value="ABB62776"/>
        <property type="gene ID" value="SDY_2731"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2731"/>
    <dbReference type="HOGENOM" id="CLU_059716_0_0_6"/>
    <dbReference type="OMA" id="YPRLMRT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="236"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="433" mass="49877" checksum="087E0B20B6AD3D2B" modified="2005-12-06" version="1">MLMGDLQMMPTLAPPSVLSAPQRRCQILLTLFQPGLTATMATFSELNGVDDDIASLDISETGREILRYHQLTLTTGYDGSYRVEGTVLNQRLCLFHWLRRGFRLCPSFITSQFTPALKSELKRRGIARNFYDDTNLQALVNLCSRRLQKRFESRDIHFLCLYLQYCLLQHHAGITPQFNPLQRRWAESCLEFQVAQEIGRHWQRRALQPVPSDEPLFMALLFSMLRVPDPLRDAHQRDRQLRQSIKRLVNHFRELGNVRFYDEQGLCDQLYTHLAQALNRSLFAIGIDNTLPEEFARLYPRLVRTTRAALAGFESEYGVHLSDEESDLVAVIFGAWLMQENDLHEKQIILLTGNDSEREAQIEQQLRELTLLPLNIKHMSVKAFLQTGAPRGAALIIAPYTMPLPLFSPPLIYTDLTLTTHQQEQIRKMLESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D40</accession>
    <name>Q32D40_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein IscX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfhJ</name>
        <name evidence="2" type="ordered locus">SDY_2720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May function as iron donor in the assembly of iron-sulfur clusters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IscX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000523616.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404256.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D40"/>
    <dbReference type="SMR" id="Q32D40"/>
    <dbReference type="STRING" id="300267.SDY_2720"/>
    <dbReference type="EnsemblBacteria" id="ABB62765">
        <property type="protein sequence ID" value="ABB62765"/>
        <property type="gene ID" value="SDY_2720"/>
    </dbReference>
    <dbReference type="GeneID" id="67416908"/>
    <dbReference type="KEGG" id="sdy:SDY_2720"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3281"/>
    <dbReference type="HOGENOM" id="CLU_168040_1_0_6"/>
    <dbReference type="OMA" id="AIQQAWI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007479">
        <property type="entry name" value="ISC_FeS_clus_asmbl_IscsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036762">
        <property type="entry name" value="IscX-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37532">
        <property type="entry name" value="PTHR37532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04384">
        <property type="entry name" value="Fe-S_assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039003">
        <property type="entry name" value="IscX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140319">
        <property type="entry name" value="SSF140319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03412">
        <property type="entry name" value="iscX_yfhJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7732" checksum="31C176F0C906AAD7" modified="2005-12-06" version="1">MGLKWTDSREIGEALYDAYPDLDPKTVRFTDMHQWICDLEDFDDDPQASNEKILEAILLVWLDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D84</accession>
    <name>Q32D84_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrogenase 4 Fe-S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hyfA</name>
        <name evidence="5" type="ordered locus">SDY_2670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404212.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D84"/>
    <dbReference type="STRING" id="300267.SDY_2670"/>
    <dbReference type="EnsemblBacteria" id="ABB62721">
        <property type="protein sequence ID" value="ABB62721"/>
        <property type="gene ID" value="SDY_2670"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2670"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3221"/>
    <dbReference type="HOGENOM" id="CLU_043374_3_0_6"/>
    <dbReference type="OMA" id="APVQCRH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12798">
        <property type="entry name" value="Fer4_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="218" mass="23597" checksum="D4370797AECD4DF9" modified="2005-12-06" version="1">MKCNVSYHFQGADMNRFVVAEPLWCTGCNTCLAACSDVHKTQGLQQHPRQALAKTSTLTAPVVCHHCEEAPCLQVCPVNAISQRDDAIQLNESLCIGCKLCAVVCPFGAISASGSRPVNAPAQYVFQAEGSLKDGEENAPTQHALLRWEPGVQTVAVKCDLCDFLPGGPACVRACPNQALRLITDDSLQRQMKEKQRLAASWFANGGEDPLSLTQEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DC8</accession>
    <name>Q32DC8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ucpA</name>
        <name evidence="1" type="ordered locus">SDY_2622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DC8"/>
    <dbReference type="STRING" id="300267.SDY_2622"/>
    <dbReference type="EnsemblBacteria" id="ABB62677">
        <property type="protein sequence ID" value="ABB62677"/>
        <property type="gene ID" value="SDY_2622"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2622"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_6"/>
    <dbReference type="OMA" id="GALPHMY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="285" mass="30683" checksum="383824195056EBD3" modified="2005-12-06" version="1">MFILYFQREWSVTLCINKESIKMGKLTGKTALITGALQGIGEGIARTFARHGANLILLDISPEIEKLADELCGRDHRCTAVVADVRDPASVAAAIKRAKEKEGRIDILVNNAGVCRLGSFLDMSDEDRDFHIDINIKGVWNVTKAVLPEMIARKDGRIVMMSSVTGDMVADPGETAYALTKAAIVGLTKSLAVEYAQSGIRVNAICPGYVRTPMAESIARQSNPEDPESVLTEMAKAIPMRRLADPLEVGELAAFLTSDESSYLTGTQNVIDGGSTLPETVSVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DH6</accession>
    <name>Q32DH6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug resistance protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">emrK</name>
        <name evidence="6" type="ordered locus">SDY_2563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000435182.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404120.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DH6"/>
    <dbReference type="SMR" id="Q32DH6"/>
    <dbReference type="STRING" id="300267.SDY_2563"/>
    <dbReference type="EnsemblBacteria" id="ABB62629">
        <property type="protein sequence ID" value="ABB62629"/>
        <property type="gene ID" value="SDY_2563"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2563"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3087"/>
    <dbReference type="HOGENOM" id="CLU_018816_15_0_6"/>
    <dbReference type="OMA" id="KEVQITH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005694">
        <property type="entry name" value="Efflux_pump_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00998">
        <property type="entry name" value="8a0101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CusB_dom_1" evidence="4">
        <location>
            <begin position="34"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="56"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="387" mass="42552" checksum="F8E71DA630F40991" modified="2005-12-06" version="1">MEQINSNKKHSNRRKYLSLLAIVLFIAFSGAYAYWSMELEDMISTDDAYVTGNADPISAQVSGSVTVVNHKDTNYVRQGDILVSLDKTDATIALNKAKNNLANIVRQTNKLYLQDKQYSAEVASARIQYQQSLEDYNRRVPLAKQGVISKETLEHTKDTLISSKAALNAAIQAYKANKALVMNTPLNRQPQVVEAADATKEAWLALKRTDIKSPVTGYIAQRSVQVGETVSPGQSLMAVVPARQMWVNANFKETQLTDVRIGQSVNIISDLYGENVVFHGRVTGINMGTGNAFSLLPAQNATGNWIKIVQRVPVEVSLDPKELMEHPLRIGLSMTATIDTKDEDIAEMPDLASTVTSMPAYTSKALVIDTSPIEKEISNIISHNGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DM3</accession>
    <name>Q32DM3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein required for colicin V production</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cvpA</name>
        <name evidence="6" type="ordered locus">SDY_2512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000262113.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404073.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DM3"/>
    <dbReference type="STRING" id="300267.SDY_2512"/>
    <dbReference type="EnsemblBacteria" id="ABB62582">
        <property type="protein sequence ID" value="ABB62582"/>
        <property type="gene ID" value="SDY_2512"/>
    </dbReference>
    <dbReference type="GeneID" id="66673804"/>
    <dbReference type="KEGG" id="sdy:SDY_2512"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3027"/>
    <dbReference type="HOGENOM" id="CLU_092720_2_1_6"/>
    <dbReference type="OMA" id="FTWVDWA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="162" mass="17990" checksum="EFAB4216782A836F" modified="2005-12-06" version="1">MVWIDYAIIAVIAFSSLVSLIRGFVREALSLVTWGCAFFVASHYYTYLSVWFTGFEDELVRNGIAIAVLFIATLIVGAIVNFVIGQLVEKTGLSGTDRVLGVCFGALRGVLIVAAILFFLDSFTGVSKSEDWSKSQLIPQFSFIIRWFFDYLQSSSSFLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DS6</accession>
    <name>Q32DS6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="3">DHNA-CoA synthase</shortName>
            <ecNumber evidence="3">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">menB</name>
        <name evidence="4" type="ordered locus">SDY_2458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000639988.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404020.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DS6"/>
    <dbReference type="STRING" id="300267.SDY_2458"/>
    <dbReference type="EnsemblBacteria" id="ABB62529">
        <property type="protein sequence ID" value="ABB62529"/>
        <property type="gene ID" value="SDY_2458"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2458"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2965"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_7_6"/>
    <dbReference type="OMA" id="IFKQTDA"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="84"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hydrogencarbonate binding" evidence="3">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="285" mass="31643" checksum="540EE4E3F2791747" modified="2005-12-06" version="1">MIYPDEAMHYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNVGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DS9</accession>
    <name>Q32DS9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polymyxin resistance protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pmrD</name>
        <name evidence="2" type="ordered locus">SDY_2455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404017.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DS9"/>
    <dbReference type="SMR" id="Q32DS9"/>
    <dbReference type="STRING" id="300267.SDY_2455"/>
    <dbReference type="EnsemblBacteria" id="ABB62526">
        <property type="protein sequence ID" value="ABB62526"/>
        <property type="gene ID" value="SDY_2455"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2455"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2962"/>
    <dbReference type="HOGENOM" id="CLU_192298_0_0_6"/>
    <dbReference type="OMA" id="WWVKKVR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044854">
        <property type="entry name" value="PmrD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038679">
        <property type="entry name" value="PmrD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11183">
        <property type="entry name" value="PmrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmrD" evidence="1">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9602" checksum="2B690D12E9C57AE1" modified="2005-12-06" version="1">MKTLSKQDNTMEWLVKKSCCNKQDNRHVLMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREKLHTVKVLSASSYSPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DT5</accession>
    <name>Q32DT5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404011.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DT5"/>
    <dbReference type="STRING" id="300267.SDY_2449"/>
    <dbReference type="EnsemblBacteria" id="ABB62520">
        <property type="protein sequence ID" value="ABB62520"/>
        <property type="gene ID" value="SDY_2449"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2449"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2953"/>
    <dbReference type="HOGENOM" id="CLU_033332_3_0_6"/>
    <dbReference type="OMA" id="KERCIGT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="175" mass="20024" checksum="3778A43744E8FE9A" modified="2005-12-06" version="1">MLKFHGLGVDAYDRQTRGRAPQAEVLTPGYKYNLTDINAAIAMTQLAKLEYLNTRRREIALQYQQALAALPFQPLSLPAWSHVHAWHLFIIRVDEQRCGISRDVLMEALKERCIGTGLHFRTAHTQKYYRERFPALSLPNTEWNSERICSLPLFPDMTTADADRVITALQQLAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DX3</accession>
    <name>Q32DX3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DX3"/>
    <dbReference type="EnsemblBacteria" id="ABB62482">
        <property type="protein sequence ID" value="ABB62482"/>
        <property type="gene ID" value="SDY_2409"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2409"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8464" checksum="46576928F4135D00" modified="2005-12-06" version="1">MITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DZ9</accession>
    <name>MACB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="1">7.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">macB</name>
        <name type="ordered locus">SDY_2382</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Part of the tripartite efflux system MacAB-TolC, which is composed of an inner membrane transporter, MacB, a periplasmic membrane fusion protein, MacA, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. Interacts with MacA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000188167.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403947.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DZ9"/>
    <dbReference type="SMR" id="Q32DZ9"/>
    <dbReference type="STRING" id="300267.SDY_2382"/>
    <dbReference type="EnsemblBacteria" id="ABB62456">
        <property type="protein sequence ID" value="ABB62456"/>
        <property type="gene ID" value="SDY_2382"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2382"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2875"/>
    <dbReference type="HOGENOM" id="CLU_000604_78_3_6"/>
    <dbReference type="OMA" id="VVILITH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51267">
        <property type="entry name" value="MACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000269980" description="Macrolide export ATP-binding/permease protein MacB">
        <location>
            <begin position="1"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="5"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01720"/>
        </source>
    </evidence>
    <sequence length="650" mass="70904" checksum="69B901901BC1F3A5" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E62</accession>
    <name>Q32E62_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphofructokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fruK</name>
        <name evidence="7" type="ordered locus">SDY_2316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14213"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.56"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000091263.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403884.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E62"/>
    <dbReference type="SMR" id="Q32E62"/>
    <dbReference type="STRING" id="300267.SDY_2316"/>
    <dbReference type="EnsemblBacteria" id="ABB62393">
        <property type="protein sequence ID" value="ABB62393"/>
        <property type="gene ID" value="SDY_2316"/>
    </dbReference>
    <dbReference type="GeneID" id="66673936"/>
    <dbReference type="KEGG" id="sdy:SDY_2316"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2794"/>
    <dbReference type="HOGENOM" id="CLU_050013_0_1_6"/>
    <dbReference type="OMA" id="GETRSNI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008662">
        <property type="term" value="F:1-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022463">
        <property type="entry name" value="1-PFruKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03828">
        <property type="entry name" value="pfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="14"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="312" mass="33756" checksum="067E5CF7C584FEA8" modified="2005-12-06" version="1">MSRRVATITLNPAYDLVGFCPEIERGEVNLVKTTGLHAAGKGINVAKVLKDLGIDVTVGGFLGKDNQDGFQQLFSELGIANRFQVVQGRTRINVKLTEKDGEVTDFNFSGFEVTPADWERFVTDSLSWLGQFDMVCVSGSLPSGVSPEAFTDWMTRLRSQCPCIIFDSSREALVAGLKAAPWLVKPNRRELEIWAGRKLPEMKDVIEAAHALREQGIAHVVISLGAEGALWVNASGEWIAKPPSVDVVSTVGAGDSMVGGLIYGLLMRESSEHTLRLATAVAALAVSQSNVGITDRPQLAAMMARVDLQPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EA2</accession>
    <name>Q32EA2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EA2"/>
    <dbReference type="STRING" id="300267.SDY_2276"/>
    <dbReference type="EnsemblBacteria" id="ABB62353">
        <property type="protein sequence ID" value="ABB62353"/>
        <property type="gene ID" value="SDY_2276"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2276"/>
    <dbReference type="HOGENOM" id="CLU_2273111_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="102" mass="11971" checksum="86EAC2E470C94E12" modified="2005-12-06" version="1">MQLRITSRKKLTALLCALVLISIVAIYPRQTVNFFYSTAVQITDYIHFYGYRPVKSFAIRIPASYTIHGIDVSRWQERIDWQRVAKMRDNGIRLQFAFIKAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ED0</accession>
    <name>COBT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="1">NN:DBI PRT</shortName>
            <ecNumber evidence="1">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobT</name>
        <name type="ordered locus">SDY_2242</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001193813.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403816.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ED0"/>
    <dbReference type="SMR" id="Q32ED0"/>
    <dbReference type="STRING" id="300267.SDY_2242"/>
    <dbReference type="EnsemblBacteria" id="ABB62325">
        <property type="protein sequence ID" value="ABB62325"/>
        <property type="gene ID" value="SDY_2242"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2242"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2712"/>
    <dbReference type="HOGENOM" id="CLU_002982_0_0_6"/>
    <dbReference type="OMA" id="AIWYAGW"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000021634" description="Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <sequence length="359" mass="37047" checksum="66E5C9E049071427" modified="2005-12-06" version="1">MQTLADLLNTIPAIDPAAMSRAQRHIDGLLKPVGSLRRLEALAIQLAGMPGLTGIPHVGKKAVLVMCADHGVWEEGVAISPKEVTGIQAENMTRGTTGVCMLAAQAGANVHVIDVGIDTAEPIPGLINMRVARGSGNIASAPAMSRRQAEKLLLDVICYTRELAKNGVTLFGVGELGMANTTPAAAIVSTITGRDPEEVVGIGANLPTDKLANKIDVVRRAITLNQPNPQDGVDVLAKVGGFDLVGMAGVMLGAASCGLPVLLDGFLSYAAALAACQMSPAIKPYLIPSHLSAEKGARIALSHLGLEPYLNMEMRLGEGSGAALAMPIIEAACAIYNNMGELAASNIVLPGNTTSDLNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EH3</accession>
    <name>DCD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dCTP deaminase</fullName>
            <ecNumber evidence="1">3.5.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxycytidine triphosphate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dcd</name>
        <name type="ordered locus">SDY_2197</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of dCTP to dUTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dCTP + H(+) + H2O = dUTP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="EC" id="3.5.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dCTP deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001234777.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403773.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EH3"/>
    <dbReference type="SMR" id="Q32EH3"/>
    <dbReference type="STRING" id="300267.SDY_2197"/>
    <dbReference type="EnsemblBacteria" id="ABB62282">
        <property type="protein sequence ID" value="ABB62282"/>
        <property type="gene ID" value="SDY_2197"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2197"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2657"/>
    <dbReference type="HOGENOM" id="CLU_087476_2_0_6"/>
    <dbReference type="OMA" id="PPIERIN"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000009817" description="dCTP deaminase">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="193" mass="21251" checksum="E0063139C04A4FC2" modified="2005-12-06" version="1">MRLCDRDIEAWLDEGRLSINPRPPVERINGATVDVRLGNKFRTFRGHTAAFIDLSGPKDEVSAALDRVMSDEIVLDESEAFYLHPGELALAVTLESVTLPADLVGWLDGRSSLARLGLMVHVTAHRIDPGWSGCIVLEFYNSGKLPLALRPGMLIGALSFEPLSGPAARPYNRREDAKYRNQQGAVASRIDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EL1</accession>
    <name>Q32EL1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-D-glucoside glucohydrolase, periplasmic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bglX</name>
        <name evidence="7" type="ordered locus">SDY_2156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000871526.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403735.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EL1"/>
    <dbReference type="STRING" id="300267.SDY_2156"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62244">
        <property type="protein sequence ID" value="ABB62244"/>
        <property type="gene ID" value="SDY_2156"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2156"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2606"/>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_6"/>
    <dbReference type="OMA" id="TLITDWD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220809" evidence="5">
        <location>
            <begin position="21"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="6">
        <location>
            <begin position="685"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="765" mass="83489" checksum="F788D7BC246FE5CB" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EP1</accession>
    <name>Q32EP1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EP1"/>
    <dbReference type="EnsemblBacteria" id="ABB62214">
        <property type="protein sequence ID" value="ABB62214"/>
        <property type="gene ID" value="SDY_2124"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2124"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="9317" checksum="700282519767B6A2" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EZ4</accession>
    <name>Q32EZ4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="3">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">icdA</name>
        <name evidence="5" type="ordered locus">SDY_2016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000444472.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403602.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EZ4"/>
    <dbReference type="STRING" id="300267.SDY_2016"/>
    <dbReference type="EnsemblBacteria" id="ABB62111">
        <property type="protein sequence ID" value="ABB62111"/>
        <property type="gene ID" value="SDY_2016"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2016"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2429"/>
    <dbReference type="HOGENOM" id="CLU_031953_7_1_6"/>
    <dbReference type="OMA" id="CVRPCRY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="PTHR43504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00183">
        <property type="entry name" value="prok_nadp_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="4">
        <location>
            <begin position="28"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="416" mass="45756" checksum="6B47FFF5439C56A5" modified="2005-12-06" version="1">MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGAPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTESADLIVKGMEGAINAKTVTYDFERLMEGAKLLKCSEFGDAIIKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EZ7</accession>
    <name>Q32EZ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403599.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EZ7"/>
    <dbReference type="EnsemblBacteria" id="ABB62108">
        <property type="protein sequence ID" value="ABB62108"/>
        <property type="gene ID" value="SDY_2013"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2013"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2426"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="OMA" id="ARHTRIK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15352" checksum="F9FACF503C57EE0B" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLTLLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FA1</accession>
    <name>Q32FA1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ni_hydr_CYTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ydhU</name>
        <name evidence="4" type="ordered locus">SDY_1898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001069988.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403495.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FA1"/>
    <dbReference type="STRING" id="300267.SDY_1898"/>
    <dbReference type="EnsemblBacteria" id="ABB62004">
        <property type="protein sequence ID" value="ABB62004"/>
        <property type="gene ID" value="SDY_1898"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1898"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2283"/>
    <dbReference type="HOGENOM" id="CLU_097472_0_0_6"/>
    <dbReference type="OMA" id="ITGWEEV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="69"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="261" mass="29563" checksum="27C24EA205824FF3" modified="2005-12-06" version="1">MNPSQHAEQFQSQLANYVPQFTPEFWPVWLIIAGVLLVGMWLVLGLHALLRARGVKKSATDHGERIYLYSKAVRLWHWSNALLFVLLLASGLINHFALVGATAVKSLVAVHEVCGFLLLACWLGFVLINAVGGNGHHYRIRRQGWLERAEKQTRFYLFGIMQGEEHPFPATTQSKFNPLQQVAYVGVMYGLLPLLLLTGLLCLYPQAVGDVFPGVRYWLLQAHFALAFISLFFIFGHLYLCTTGRTPHETFKSMVDGYHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FC4</accession>
    <name>Q32FC4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403472.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FC4"/>
    <dbReference type="STRING" id="300267.SDY_1873"/>
    <dbReference type="EnsemblBacteria" id="ABB61982">
        <property type="protein sequence ID" value="ABB61982"/>
        <property type="gene ID" value="SDY_1873"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1873"/>
    <dbReference type="HOGENOM" id="CLU_162538_0_1_6"/>
    <dbReference type="OMA" id="KQRYLRI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010710">
        <property type="entry name" value="DUF1289"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35175">
        <property type="entry name" value="PTHR35175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06945">
        <property type="entry name" value="DUF1289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14331" checksum="59B86363C4EF775E" modified="2005-12-06" version="1">MFASIMFGVFVHALECSRPVGLVQAKLLLWALTASIMVIILSEEGEVAEQLEFFPVQSPCRGICQSDERGFCRGCFRSRDERFNWNKMSDGEKQEVLRLCRQRLMRKLRANKPASSDEPEQPSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FG9</accession>
    <name>Q32FG9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rstB</name>
        <name evidence="12" type="ordered locus">SDY_1825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000732491.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403427.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FG9"/>
    <dbReference type="STRING" id="300267.SDY_1825"/>
    <dbReference type="EnsemblBacteria" id="ABB61936">
        <property type="protein sequence ID" value="ABB61936"/>
        <property type="gene ID" value="SDY_1825"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1825"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2198"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_27_6"/>
    <dbReference type="OMA" id="IDNIAHE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="158"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="218"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB61936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="433" mass="49329" checksum="251456466FE8AA89" modified="2005-12-06" version="1">MKKLFIQFYLLLFVCFLVMSLLVGLVYKFTAERAGKQSLDDLMNSSLYLMRSELREIPPHDWGKTLKEMDLNLSFDLRVEPLSKYHLDDISMHRLRGGEIVALDDQYTFLQRIPRSHYVLAVGPVPYLYYLHQMRLLDIALIAFIAISLAFPVFIWMRPHWQDMLKLEAAAQRFGDGHLNERIHFDEGSSFERLGIAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAAESQALNRDISQLEALIEELLTYARLDRPQNELHLSEPDLPLWLSTHLADIQAVTPDKTVRIKTLMQGHYAALDMRLMERVLDNLLNNALRYCHSTVETSLLLSGNRATLIVEDDGPGIAPENREHIFEPFVRLDPSRDRSTGGCGLGLAIVHSIALAMGGTVNCDTSELGGARFSFSWPLWHNIPQFTSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FJ0</accession>
    <name>BTUD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vitamin B12 import ATP-binding protein BtuD</fullName>
            <ecNumber evidence="1">7.6.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Vitamin B12-transporting ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">btuD</name>
        <name type="ordered locus">SDY_1804</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an R-cob(III)alamin(out) + ATP + H2O = ADP + an R-cob(III)alamin(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140785"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000029466.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403406.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FJ0"/>
    <dbReference type="SMR" id="Q32FJ0"/>
    <dbReference type="STRING" id="300267.SDY_1804"/>
    <dbReference type="EnsemblBacteria" id="ABB61915">
        <property type="protein sequence ID" value="ABB61915"/>
        <property type="gene ID" value="SDY_1804"/>
    </dbReference>
    <dbReference type="GeneID" id="66674397"/>
    <dbReference type="KEGG" id="sdy:SDY_1804"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2176"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_6"/>
    <dbReference type="OMA" id="HHADRVW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01005">
        <property type="entry name" value="BtuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023693">
        <property type="entry name" value="ABC_transptr_BtuD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000083966" description="Vitamin B12 import ATP-binding protein BtuD">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01005"/>
        </source>
    </evidence>
    <sequence length="249" mass="27111" checksum="193464EB5F777253" modified="2005-12-06" version="1">MSIVMQLQDVAESTRLGPLSGEVRAGEILHLVGPNGAGKSTLLARMAGMTSGKGSIQFAGQPLEAWSATKLALHRAYLSQQQTPPFAMPVWHYLTLHQHDKTRTELLNDVAGALALDDKLGRSTNQLSGGEWQRVRLAAVVLQITPQANPAGQLLLLDEPMNSLDVAQQSALDKILSALCQQGLAIVMSSHDLNHTLRHAHRAWLLKGGKMLASGRREEVLTPPNLAQAYGMNFRRLDIEGHRMLISTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FL0</accession>
    <name>Q32FL0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FL0"/>
    <dbReference type="EnsemblBacteria" id="ABB61895">
        <property type="protein sequence ID" value="ABB61895"/>
        <property type="gene ID" value="SDY_1781"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1781"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="TQHWLWY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="115" mass="13596" checksum="FD7D5D2C590DF5FF" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FL3</accession>
    <name>Q32FL3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403383.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FL3"/>
    <dbReference type="EnsemblBacteria" id="ABB61892">
        <property type="protein sequence ID" value="ABB61892"/>
        <property type="gene ID" value="SDY_1777"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1777"/>
    <dbReference type="HOGENOM" id="CLU_162059_2_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="78" mass="8780" checksum="FD0D46EAAA8A35E2" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITDFRCSFVARHSNSADLSTGLFWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FX6</accession>
    <name>Q32FX6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative oxidoreductase, major subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_1658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000726693.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403270.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FX6"/>
    <dbReference type="STRING" id="300267.SDY_1658"/>
    <dbReference type="EnsemblBacteria" id="ABB61779">
        <property type="protein sequence ID" value="ABB61779"/>
        <property type="gene ID" value="SDY_1658"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1658"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1999"/>
    <dbReference type="HOGENOM" id="CLU_000422_16_1_6"/>
    <dbReference type="OMA" id="PRSLKCH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="5">
        <location>
            <begin position="108"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="6">
        <location>
            <begin position="642"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="759" mass="83449" checksum="C2921F8A1F1B9BE0" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G05</accession>
    <name>TAM_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trans-aconitate 2-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tam</name>
        <name type="ordered locus">SDY_1625</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:14969"/>
            <dbReference type="ChEBI" id="CHEBI:15708"/>
            <dbReference type="ChEBI" id="CHEBI:57470"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.144"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. Tam family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.144" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001286580.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403241.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G05"/>
    <dbReference type="SMR" id="Q32G05"/>
    <dbReference type="STRING" id="300267.SDY_1625"/>
    <dbReference type="EnsemblBacteria" id="ABB61750">
        <property type="protein sequence ID" value="ABB61750"/>
        <property type="gene ID" value="SDY_1625"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1625"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1957"/>
    <dbReference type="HOGENOM" id="CLU_037990_5_2_6"/>
    <dbReference type="OMA" id="YLAFADH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00560">
        <property type="entry name" value="Tran_acon_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023506">
        <property type="entry name" value="Trans-aconitate_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000056580" description="Trans-aconitate 2-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00560"/>
        </source>
    </evidence>
    <sequence length="252" mass="28981" checksum="98DBBE865066D9D5" modified="2005-12-06" version="1">MSDWNPSLYLHFAAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLHQRWPAARITGIDSSPAMIAEARSALPDCQFVEADIRNWQPEQALDLIFANASLQWLPDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYSDRGREPLAGVHAYYDILSEAGCEVDIWRTTYYHQMPSRQAIIDWVTATGLRPWLQDLTESEQQLFLTRYHQMLEEQYPLQENGQILLAFPRLFIVARRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G21</accession>
    <name>Q32G21_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yddM</name>
        <name evidence="2" type="ordered locus">SDY_1607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403225.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G21"/>
    <dbReference type="STRING" id="300267.SDY_1607"/>
    <dbReference type="EnsemblBacteria" id="ABB61734">
        <property type="protein sequence ID" value="ABB61734"/>
        <property type="gene ID" value="SDY_1607"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1607"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1932"/>
    <dbReference type="HOGENOM" id="CLU_140230_2_1_6"/>
    <dbReference type="OMA" id="WMNLQTS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="120" mass="13264" checksum="27F5B45288FCBC2D" modified="2005-12-06" version="1">MDYCCVGRNNNDSVPSEGTLLRVKTLMKIANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWTLAEAEKTVDVSRLRRLVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G27</accession>
    <name>Q32G27_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G27"/>
    <dbReference type="EnsemblBacteria" id="ABB61728">
        <property type="protein sequence ID" value="ABB61728"/>
        <property type="gene ID" value="SDY_1600"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1600"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="79" mass="8823" checksum="1786EC93CEFFC746" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITKHCFPQSGVATGRYAGSRRLHLQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G37</accession>
    <name>Q32G37_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BOF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ydeI</name>
        <name evidence="4" type="ordered locus">SDY_1589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000671733.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403209.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G37"/>
    <dbReference type="STRING" id="300267.SDY_1589"/>
    <dbReference type="EnsemblBacteria" id="ABB61718">
        <property type="protein sequence ID" value="ABB61718"/>
        <property type="gene ID" value="SDY_1589"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1589"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1908"/>
    <dbReference type="HOGENOM" id="CLU_118907_2_1_6"/>
    <dbReference type="OMA" id="MHDGATV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036700">
        <property type="entry name" value="BOBF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005220">
        <property type="entry name" value="BOF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016052">
        <property type="entry name" value="YgiW/YdeI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04076">
        <property type="entry name" value="BOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101756">
        <property type="entry name" value="SSF101756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00156">
        <property type="entry name" value="TIGR00156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221093" description="BOF domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="BOF" evidence="3">
        <location>
            <begin position="30"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="130" mass="14107" checksum="677D4CA6CA63C45B" modified="2005-12-06" version="1">MKFQAIVLASFLVMPYALADDQGGLKQDAAPPPPHAIEDGYRGTDDAKKMTVDFAKTMHDGASVSLRGNLISHKGDDRYVFRDKSGEINVVIPAAVFDGREVQPDQMINISGSLDKKSAPAVVRVTHLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GB0</accession>
    <name>Q32GB0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protease 4</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Endopeptidase IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Signal peptide peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sppA</name>
        <name evidence="7" type="ordered locus">SDY_1507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001259856.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403136.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GB0"/>
    <dbReference type="STRING" id="300267.SDY_1507"/>
    <dbReference type="EnsemblBacteria" id="ABB61645">
        <property type="protein sequence ID" value="ABB61645"/>
        <property type="gene ID" value="SDY_1507"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1507"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1800"/>
    <dbReference type="HOGENOM" id="CLU_008856_1_1_6"/>
    <dbReference type="OMA" id="DPKGQYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07019">
        <property type="entry name" value="S49_SppA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004634">
        <property type="entry name" value="Pept_S49_pIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033854">
        <property type="entry name" value="S49_SppA_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001217">
        <property type="entry name" value="Protease_4_SppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00705">
        <property type="entry name" value="SppA_67K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="6">
        <location>
            <begin position="141"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="6">
        <location>
            <begin position="392"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="618" mass="67187" checksum="9CFED845F73C0DAC" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GB2</accession>
    <name>Q32GB2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isochorismatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydjB</name>
        <name evidence="2" type="ordered locus">SDY_1505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GB2"/>
    <dbReference type="STRING" id="300267.SDY_1505"/>
    <dbReference type="EnsemblBacteria" id="ABB61643">
        <property type="protein sequence ID" value="ABB61643"/>
        <property type="gene ID" value="SDY_1505"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1505"/>
    <dbReference type="HOGENOM" id="CLU_068979_13_1_6"/>
    <dbReference type="OMA" id="DFVDSWP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="24004" checksum="90C127CB707C4A3B" modified="2005-12-06" version="1">MIKETAMPPRALLLVDLQNDFCAGGALAVPEGDSTVDVANRLIDWCQSRGEAVIASQDWHPANHGSFASQHGVEPYTPGQLDGLPQTFWPDHCVQNSEGAQLHPLLNQKAIAAVFHKGENPLVDSYSAFFDNGRRQKTSLDDWLRDQEIDELIVMGLATDYCVKFTVLDALQLGYKVNVITDGCRGVNIQPQDSAHAFMEMSAAGATLYTLADWEETQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GB7</accession>
    <name>Q32GB7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GB7"/>
    <dbReference type="EnsemblBacteria" id="ABB61638">
        <property type="protein sequence ID" value="ABB61638"/>
        <property type="gene ID" value="SDY_1500"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1500"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="117" mass="13152" checksum="F3BFBF442218EA7B" modified="2005-12-06" version="1">MAVKPGNTGSGTRITPKQGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTLVMLPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GH8</accession>
    <name>Q32GH8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001265032.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403068.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GH8"/>
    <dbReference type="STRING" id="300267.SDY_1434"/>
    <dbReference type="EnsemblBacteria" id="ABB61577">
        <property type="protein sequence ID" value="ABB61577"/>
        <property type="gene ID" value="SDY_1434"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1434"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1710"/>
    <dbReference type="HOGENOM" id="CLU_068644_0_0_6"/>
    <dbReference type="OMA" id="MYCESDI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010373">
        <property type="entry name" value="DUF968"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06147">
        <property type="entry name" value="DUF968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="266"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="349" mass="39229" checksum="E8FCAB1B8F37D9CB" modified="2005-12-06" version="1">MRVLLRPVLVPELGLVIVKPGRESMPVFHNTRLLVEPEPKSMRNLPSGVVPAARQPLVEDKTLLPFFSNARVIRAAGGAGALSDWLLRHIKSCQWPHGDYHHSETVIHRYGTGAMVLCWHCDNQLRDQTSESLEQLAHQNLSAWMIDVIGHAISGTQERELSLAELSWWAVRNQEADALPEAVLRRSLGLRAEKIRSMYCESDIVPGEQTATSILKQRTKNLAPLPHAHQQQNPPQEKTVVSIAVDPESPESFMKRPKRRRWVNEKYTRWVKTQPCACCGKPADDPHHLIGHGQGGMGTKSHDIFALPLCREHHNELHADPLAFEEKHGSQVDLIFRFLDHAFATGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GK3</accession>
    <name>Q32GK3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator LYSR-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycjZ</name>
        <name evidence="3" type="ordered locus">SDY_1408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000817681.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403043.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GK3"/>
    <dbReference type="STRING" id="300267.SDY_1408"/>
    <dbReference type="EnsemblBacteria" id="ABB61552">
        <property type="protein sequence ID" value="ABB61552"/>
        <property type="gene ID" value="SDY_1408"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1408"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1672"/>
    <dbReference type="HOGENOM" id="CLU_039613_16_1_6"/>
    <dbReference type="OMA" id="TCIYALR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="299" mass="33554" checksum="604756B798629A65" modified="2005-12-06" version="1">MKREEIADLMAFVVVAEERSFTRAAARLSMAQSALSQIVRRIEERLGLRLLTRTTRSVVPTEAGEHLLSILGPMLHDIDSALTSLSDLQNRPSGTIRITTVEHAAKTILLPAMRTFLKSHPEIDIQLTIDYGLTDVVSERFDACVRLGGEMDKDMIAIRIGPDIPMAIVGSPDYFSRRSVPTSVSQLIDHQAINLYLPTSGTANRWRLIRGGREVRVRMEGQLLLNTIDLIIDAAIDGHGLAYLPYDQVERAIKEKKLIRVLDKFTPDLPGYHLYYPHRRHAGSAFSLFIDRLKYKGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GV5</accession>
    <name>Q32GV5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">OppC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">oppC</name>
        <name evidence="9" type="ordered locus">SDY_1303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000979659.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402941.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GV5"/>
    <dbReference type="STRING" id="300267.SDY_1303"/>
    <dbReference type="EnsemblBacteria" id="ABB61450">
        <property type="protein sequence ID" value="ABB61450"/>
        <property type="gene ID" value="SDY_1303"/>
    </dbReference>
    <dbReference type="GeneID" id="67417437"/>
    <dbReference type="KEGG" id="sdy:SDY_1303"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1549"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_3_6"/>
    <dbReference type="OMA" id="YYRVVRN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="101"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="302" mass="33032" checksum="A88AD4D22D0AC3D0" modified="2005-12-06" version="1">MMLSKKNSETLENFSEKLEVEGRSLWQDARRRFMHNRAAVASLIVLVLIALFVILAPMLSQFAYDDTDWAMMSSAPDMESGHYFGTDSSGRDLLVRVAIGGRISLMVGVAAALVAVVVGTLYGSLSGYLGGKVDSVMMRLLEILNSFPFMFFVILLVTFFGQNILLIFVAIGMVSWLDMARIVRGQTLSLKRKEFIEAAQVGGVSTPGIVIRHIVPNVLGVVVVYASLLVPSMILFESFLSFLGLGTQEPLSSWGALLSDGANSMEVSPWLLLFPAGFLVVTLFCFNFIGDGLRDALDPKDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H30</accession>
    <name>NHAB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Na(+)/H(+) antiporter NhaB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sodium/proton antiporter NhaB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nhaB</name>
        <name type="ordered locus">SDY_1223</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H(+)(out) + 2 Na(+)(in) = 3 H(+)(in) + 2 Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29248"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000406391.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402866.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H30"/>
    <dbReference type="SMR" id="Q32H30"/>
    <dbReference type="STRING" id="300267.SDY_1223"/>
    <dbReference type="EnsemblBacteria" id="ABB61375">
        <property type="protein sequence ID" value="ABB61375"/>
        <property type="gene ID" value="SDY_1223"/>
    </dbReference>
    <dbReference type="GeneID" id="66674994"/>
    <dbReference type="KEGG" id="sdy:SDY_1223"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1451"/>
    <dbReference type="HOGENOM" id="CLU_041110_0_0_6"/>
    <dbReference type="OMA" id="QFEMLAV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01599">
        <property type="entry name" value="NhaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004671">
        <property type="entry name" value="Na+/H+_antiporter_NhaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF1">
        <property type="entry name" value="PTHR43302:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06450">
        <property type="entry name" value="NhaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00774">
        <property type="entry name" value="NhaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0915">Sodium</keyword>
    <keyword id="KW-0739">Sodium transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000333140" description="Na(+)/H(+) antiporter NhaB">
        <location>
            <begin position="1"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
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            <end position="140"/>
        </location>
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        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
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        <location>
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            <end position="222"/>
        </location>
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        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
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        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
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        <location>
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            <end position="411"/>
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    </feature>
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        <location>
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            <end position="467"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <sequence length="513" mass="56728" checksum="B5D85BD8E761E2BB" modified="2005-12-06" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
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            <authorList>
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                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
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                <person name="Hou Y."/>
                <person name="Yu J."/>
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            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </evidence>
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    </evidence>
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    <sequence length="864" mass="90481" checksum="8F9F46DCC031DF58" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-07" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
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                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
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                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YebF family.</text>
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        <conflict type="erroneous initiation">
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    </comment>
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    </dbReference>
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        <property type="entry name" value="YEBF_CMI"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword id="KW-0732">Signal</keyword>
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        <location>
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            <end position="21"/>
        </location>
    </feature>
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            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="YebF/Cmi" evidence="2">
        <location>
            <begin position="31"/>
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    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="35"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01435"/>
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    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
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</entry>
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        </submittedName>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
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                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HS7"/>
    <dbReference type="STRING" id="300267.SDY_0956"/>
    <dbReference type="EnsemblBacteria" id="ABB61128">
        <property type="protein sequence ID" value="ABB61128"/>
        <property type="gene ID" value="SDY_0956"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0956"/>
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    <dbReference type="OMA" id="YVAHDTN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221111" evidence="1">
        <location>
            <begin position="23"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="434" mass="47328" checksum="B6BC33F1653EF40C" modified="2005-12-06" version="1">MKAILIPFLSLLIPLTPQSAFAQSEPEPELKLESVVIVSRHGVRAPTKATQLMQDVTPDAWPTWPVKLGWLTPRGGELIAYLGHYQRQRLVADGLLTKKGCPQPGQVAIIADVDERTRKTGEAFDAGLAPDCAITVHTQADTSSPDPLFNPLKTGVCQLDNANVTDAILSRAGGSIADFTGHRQTAFCELERVLNFPQSNLCLNREKQDESCSLTQALPSELKVSADNVSLNGAVSLASMLTEIFLLQQAQGMPEPGWGRITDSHQWNTLLSLHNAQFYLLQRTPEVARSRATPLLDLIMTALTPHPPQKQAYGVILPTSVLFIAGHDTNLANLGGALELNWTLPGQPDNTPPGGELVFERWRRLSDNSQWIQVSLVFQTLQQMRDKTPLSLNTPPGEVKLTLAGCEERNAQGMCSLAGFTQIVNEARIPACSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HX3</accession>
    <name>Q32HX3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yeiR</name>
        <name evidence="2" type="ordered locus">SDY_0906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000198788.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402573.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HX3"/>
    <dbReference type="STRING" id="300267.SDY_0906"/>
    <dbReference type="EnsemblBacteria" id="ABB61082">
        <property type="protein sequence ID" value="ABB61082"/>
        <property type="gene ID" value="SDY_0906"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0906"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1047"/>
    <dbReference type="HOGENOM" id="CLU_017452_1_2_6"/>
    <dbReference type="OMA" id="WSIGWRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="1">
        <location>
            <begin position="240"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="328" mass="36319" checksum="373F457C312BA74A" modified="2005-12-06" version="1">MTRTNLITGFLGSGKTTSILHLLAHKDPNEKWAVLVNEFGEVGIDGALLADSDTLLKEIPGGCMCCVNDLPMQVGLNTLLRQGKPDRLLIEPTGLGHPKQILDLLTAPVYEPWIDLRATLCILDPRLLLDEKSASNENFRDQLAAADIIVANKSDRATPESEQALQRWWQQNGGDRQLIHSEHGKVDGHLLDLPRRNLTELPASAAHSHQHVVKKGLAALSLPEHQRWRRSLNSGQGHQACGWIFDADTVFDTIGILEWARLAPVERVKGVLRIPEGLVRINRQDDDLHIETQNVAPPDSRIELISSSEADWNALQSALLKLRLATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I87</accession>
    <name>Q32I87_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding component of glutamine high-affinity transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glnQ</name>
        <name evidence="8" type="ordered locus">SDY_0787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000569103.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402459.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I87"/>
    <dbReference type="STRING" id="300267.SDY_0787"/>
    <dbReference type="EnsemblBacteria" id="ABB60970">
        <property type="protein sequence ID" value="ABB60970"/>
        <property type="gene ID" value="SDY_0787"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0787"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.907"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="EFIYIIG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="240" mass="26709" checksum="2D089E029ACBEF93" modified="2005-12-06" version="1">MIEFKNVSKHFGPTQVLNNIDLNIAQGEVVVIIGPSGSGKSTLLRCINKLEEITSGDLIVDGLKVNDPKVDERLIRQEAGMVFQQFYLFPHLTALENVMFGPLRVRGANKEEAEKLARELLAKVGLAERAHHYPSELSGGQQQRVAIARALAVKPKMMLFDEPTSALDPELRHEVLKVMQDLAEEGMTMVIVTHEIGFAEKVASRLIFIDKGRIAEDGDPQVLIKNPPSQRLQEFLQHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IE9</accession>
    <name>Q32IE9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402397.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IE9"/>
    <dbReference type="EnsemblBacteria" id="ABB60908">
        <property type="protein sequence ID" value="ABB60908"/>
        <property type="gene ID" value="SDY_0724"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0724"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.837"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="298" mass="34512" checksum="BF66EABE1AD113C5" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSHITSVQVAKFSVPLHLPLSPDKLTRTSKSIYRKQRAALFTRSFTT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IG0</accession>
    <name>MODC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdenum import ATP-binding protein ModC</fullName>
            <ecNumber evidence="1">7.3.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">modC</name>
        <name type="ordered locus">SDY_0712</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + molybdate(out) = ADP + H(+) + molybdate(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.3.2.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (ModC), two transmembrane proteins (ModB) and a solute-binding protein (ModA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family.</text>
    </comment>
    <dbReference type="EC" id="7.3.2.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000891685.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402386.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IG0"/>
    <dbReference type="SMR" id="Q32IG0"/>
    <dbReference type="STRING" id="300267.SDY_0712"/>
    <dbReference type="EnsemblBacteria" id="ABB60897">
        <property type="protein sequence ID" value="ABB60897"/>
        <property type="gene ID" value="SDY_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0712"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.823"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_6"/>
    <dbReference type="OMA" id="QWLYAQI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015412">
        <property type="term" value="F:ABC-type molybdate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011868">
        <property type="entry name" value="ModC_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02142">
        <property type="entry name" value="modC_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51241">
        <property type="entry name" value="MODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0500">Molybdenum</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000271694" description="Molybdenum import ATP-binding protein ModC">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="2">
        <location>
            <begin position="289"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <sequence length="352" mass="39114" checksum="15D9D6C3011AFDB8" modified="2005-12-06" version="1">MLELNFSQTLGNHCLTINETLPANGITAIFGVSGAGKTSLINAISGLTRPQKGRIVLNGRVLNDAEKGICLTPEKRRVGYVFQDARLFPHYKVRGNLRYGMAKSMVDQFDKLVALLGIEPLLDRLPGSLSGGEKQRVAIGRALLTAPELLLLDEPLASLDIPRKRELLPYLQRLTREINIPMLYVSHSLDEILHLADRVMVLENGQVKAFGALEEVWGSSVMNPWLPKEQQSSILKVTVLEHHPHYAMTALALGDQHLWVNKLDEPLQAALRIRIQASDVSLVLQPPQQTSIRNVLRAKVVNSYDDNGQVEVELEVGGKTLWARISPWARDELVIKPGLWLYAQIKSVSITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32II9</accession>
    <name>Q32II9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome d terminal oxidase, polypeptide subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cydA</name>
        <name evidence="13" type="ordered locus">SDY_0680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402357.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32II9"/>
    <dbReference type="STRING" id="300267.SDY_0680"/>
    <dbReference type="EnsemblBacteria" id="ABB60868">
        <property type="protein sequence ID" value="ABB60868"/>
        <property type="gene ID" value="SDY_0680"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0680"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.794"/>
    <dbReference type="HOGENOM" id="CLU_030555_3_3_6"/>
    <dbReference type="OMA" id="FLINIAM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB60868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="523" mass="58289" checksum="5AEF52768AC428E7" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IN3</accession>
    <name>Q32IN3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">KdpF protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kdpF</name>
        <name evidence="1" type="ordered locus">SDY_0634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378615.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402313.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IN3"/>
    <dbReference type="EnsemblBacteria" id="ABB60824">
        <property type="protein sequence ID" value="ABB60824"/>
        <property type="gene ID" value="SDY_0634"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0634"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.740"/>
    <dbReference type="HOGENOM" id="CLU_202373_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="29" mass="3072" checksum="5C25F73ED3B16321" modified="2005-12-06" version="1">MSTGVIAGVLLVFLLLGYLVYALINAEAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IQ2</accession>
    <name>NAGB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="1">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GlcN6P deaminase</fullName>
            <shortName evidence="1">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nagB</name>
        <name type="ordered locus">SDY_0612</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer; trimer of disulfide-linked dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001237084.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402294.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IQ2"/>
    <dbReference type="SMR" id="Q32IQ2"/>
    <dbReference type="STRING" id="300267.SDY_0612"/>
    <dbReference type="EnsemblBacteria" id="ABB60805">
        <property type="protein sequence ID" value="ABB60805"/>
        <property type="gene ID" value="SDY_0612"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0612"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.708"/>
    <dbReference type="HOGENOM" id="CLU_049611_0_1_6"/>
    <dbReference type="OMA" id="FNEPCSS"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000067019" description="Glucosamine-6-phosphate deaminase">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <sequence length="266" mass="29803" checksum="D1A794A06CDD97E8" modified="2005-12-06" version="1">MRLIPLTTAEQVGKWAARHIVNRINAFKPTANRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVITFNMDEYVGLPKEHPESYYSFMHRNFFDHVDIPAENINLLNGNALDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCDEPSTMELKVKTLRYFNELEAENIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IR5</accession>
    <name>Q32IR5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="9">ALP N-acyltransferase</shortName>
            <ecNumber evidence="9">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">lnt</name>
        <name evidence="11" type="ordered locus">SDY_0593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000853007.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402281.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IR5"/>
    <dbReference type="STRING" id="300267.SDY_0593"/>
    <dbReference type="EnsemblBacteria" id="ABB60792">
        <property type="protein sequence ID" value="ABB60792"/>
        <property type="gene ID" value="SDY_0593"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0593"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.697"/>
    <dbReference type="HOGENOM" id="CLU_019563_3_0_6"/>
    <dbReference type="OMA" id="IPQSMKW"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="227"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="512" mass="57043" checksum="82D45E035441036F" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IW8</accession>
    <name>Q32IW8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybdM</name>
        <name evidence="2" type="ordered locus">SDY_0533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IW8"/>
    <dbReference type="STRING" id="300267.SDY_0533"/>
    <dbReference type="EnsemblBacteria" id="ABB60739">
        <property type="protein sequence ID" value="ABB60739"/>
        <property type="gene ID" value="SDY_0533"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0533"/>
    <dbReference type="HOGENOM" id="CLU_105812_1_0_6"/>
    <dbReference type="OMA" id="YKSPVYN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="51"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="167" mass="18909" checksum="6564667746CFF07F" modified="2005-12-06" version="1">MGDTMQQRLTQDLTQFLASLPEDDRINAINEIRMAIHQVSPFREEPVDCVLWVKNSQLMPNDYNPNNVAPPEKKLLKKSIEIDGFTQPIVVTHTDKNALEIVDGFHRHEIGKGSSSLKLCLKGYLPVTCLEGTRNQRIAATIRHNRARGRHQITAMSEIVRELSQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IY7</accession>
    <name>Q32IY7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Enterochelin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fes</name>
        <name evidence="5" type="ordered locus">SDY_0513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Fes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402209.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IY7"/>
    <dbReference type="STRING" id="300267.SDY_0513"/>
    <dbReference type="ESTHER" id="shifl-FES">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60720">
        <property type="protein sequence ID" value="ABB60720"/>
        <property type="gene ID" value="SDY_0513"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0513"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.606"/>
    <dbReference type="HOGENOM" id="CLU_024314_3_0_6"/>
    <dbReference type="OMA" id="VEQCPID"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008849">
        <property type="term" value="F:enterochelin esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021764">
        <property type="entry name" value="Enterochelin_esterase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11806">
        <property type="entry name" value="DUF3327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3327" evidence="4">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="374" mass="42575" checksum="AE75C4FD658C070C" modified="2005-12-06" version="1">MFEVTFWWRDPQGSEEYSTIKRVWVYITGVTDHHQNSQPQSMQRIAGTDVWQWTTQLNANWRGSYCFIPTERDDIFSAPSPDRLELREGWRKLLPQAIADPLNPQSWKGGRGHAVSALEMPQAPLQPGWDCPQAPEIPAKEIIWKSERLENSRRVWIFTTGDVTAEERPLAVLLDGEFWAQSMPVWPVLTSLTHRQQLPPAVYVLIDAIDTTHRAHELPCNADFWLAVQQELLPLVKAIAPFSDRADRTVVAGQSFGGLSALYAGLHWPERFGCVLSQSGSYWWPHRGGQQEGVLLEKLKAGEVSAEGLRIVLEAGIREPMIMRANQALYAQLHPIKESIFWRQVDGGHDAFCWRGGLMQGLIDLWQPLFHDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J61</accession>
    <name>Q32J61_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybaP</name>
        <name evidence="1" type="ordered locus">SDY_0436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000365184.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402135.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J61"/>
    <dbReference type="STRING" id="300267.SDY_0436"/>
    <dbReference type="EnsemblBacteria" id="ABB60646">
        <property type="protein sequence ID" value="ABB60646"/>
        <property type="gene ID" value="SDY_0436"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0436"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.517"/>
    <dbReference type="HOGENOM" id="CLU_057525_3_0_6"/>
    <dbReference type="OMA" id="QTMISWW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="264" mass="29904" checksum="63A3C0ABA7204484" modified="2005-12-06" version="1">MDLLYRVKTLWAALRGNHYTWPAIDITLPGNRHFHLIGSIHMGSHDMAPLPTRLLKKLKNADALIVEADVSTSDTPFANLPTCEALKERISEEQLQNLQHISQEMGISPSLFSTQPLWQIAMVLQATQAQKLGLRAEYGIDYQLLQAAKQQHKPAIELEGAENQIAMLLQLPDKGLALLDDTLTHWHTNARLLQQMMSWWLNAPPQNNDITLPNTFSQSLYDVLMHQRNLAWRDKLRAMPPGRYVVAVGALHLYGEGNLPQMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JB7</accession>
    <name>Q32JB7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JB7"/>
    <dbReference type="EnsemblBacteria" id="ABB60590">
        <property type="protein sequence ID" value="ABB60590"/>
        <property type="gene ID" value="SDY_0377"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0377"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="OMA" id="ICELDDQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="138" mass="16076" checksum="46E776192BA3885C" modified="2005-12-06" version="1">MPVAHADVALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKHKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JE4</accession>
    <name>Q32JE4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JE4"/>
    <dbReference type="EnsemblBacteria" id="ABB60563">
        <property type="protein sequence ID" value="ABB60563"/>
        <property type="gene ID" value="SDY_0348"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0348"/>
    <dbReference type="HOGENOM" id="CLU_921002_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024497">
        <property type="entry name" value="DUF2773"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10971">
        <property type="entry name" value="DUF2773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="302" mass="35285" checksum="7485041064E378E5" modified="2005-12-06" version="1">MSKDRSLKVREALARTLTELKITQLSATLRTEDIERIAEQMYLDNKENKNIVKALLIALPEMRQLSLAKEDVHNLREGARYLTSKDVISYLLTQHDVPTVWDELARDKLLPLEYKKQLWQRTLNLMMSKRQEDQEQAYEVQLALIDNGVVDEEMLNNAIDLLVDLPAEYRYRMRNQLFDNKDLPSGIINKLDQQYRFNSDWVLSVVSMKNSTRRQSERGLHRWNREDSDIFAELATIKDKSDDEWWRALLQSRNDHLRQTALRNAHTPASLLTTLTEPQDRSLAINNPQLAADVKTAWLKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JT6</accession>
    <name>Q32JT6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yaeM</name>
        <name evidence="7" type="synonym">dxr</name>
        <name evidence="11" type="ordered locus">SDY_0189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000811921.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401910.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JT6"/>
    <dbReference type="STRING" id="300267.SDY_0189"/>
    <dbReference type="EnsemblBacteria" id="ABB60421">
        <property type="protein sequence ID" value="ABB60421"/>
        <property type="gene ID" value="SDY_0189"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0189"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.219"/>
    <dbReference type="HOGENOM" id="CLU_035714_4_0_6"/>
    <dbReference type="OMA" id="PIDSEHF"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="146"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="271"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="398" mass="43388" checksum="FC52FDF3B0AF1356" modified="2005-12-06" version="1">MKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFCKLSALAFAAPDYDRYPCLKLAMEAFEQGQAATTALNTANEITVAAFLAQQIRFTDIAALNLSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JT9</accession>
    <name>EFTS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor Ts</fullName>
            <shortName evidence="1">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsf</name>
        <name type="ordered locus">SDY_0186</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000818114.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401907.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JT9"/>
    <dbReference type="SMR" id="Q32JT9"/>
    <dbReference type="STRING" id="300267.SDY_0186"/>
    <dbReference type="EnsemblBacteria" id="ABB60418">
        <property type="protein sequence ID" value="ABB60418"/>
        <property type="gene ID" value="SDY_0186"/>
    </dbReference>
    <dbReference type="GeneID" id="66671542"/>
    <dbReference type="KEGG" id="sdy:SDY_0186"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.216"/>
    <dbReference type="HOGENOM" id="CLU_047155_0_2_6"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000241528" description="Elongation factor Ts">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="1">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <sequence length="283" mass="30423" checksum="0B9D21E928A5051C" modified="2005-12-06" version="1">MAEITASLVKELRERTGAGMMDCKKALTEANGDIELAIENMRKSGAIKAAKKAGNVAADGVIKTKIDGNYGIILEVNCQTDFVAKDAGFQAFADKVLDAAVAGKITDVEVLKAQFEEERVALVAKIGENINIRRVAALEGDVLGSYQHGARIGVLVAAKGADEELVKHIAMHVAASKPEFIKPEDVSAEVVEKEYQVQLDIAMQSGKPKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPSKTVGQLLKEHNAEVTGFIRFEVGEGIEKVETDFAAEVAAMSKQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K02</accession>
    <name>MURG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murG</name>
        <name type="ordered locus">SDY_0120</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000016568.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401844.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K02"/>
    <dbReference type="SMR" id="Q32K02"/>
    <dbReference type="STRING" id="300267.SDY_0120"/>
    <dbReference type="CAZy" id="GT28">
        <property type="family name" value="Glycosyltransferase Family 28"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60355">
        <property type="protein sequence ID" value="ABB60355"/>
        <property type="gene ID" value="SDY_0120"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0120"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.139"/>
    <dbReference type="HOGENOM" id="CLU_037404_2_0_6"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000225095" description="UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="263"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <sequence length="355" mass="37817" checksum="CF70737EA6FD25BE" modified="2005-12-06" version="1">MSGQGKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIEIDFIRISGLRGKGIKALIAAPLRIFNAWRQARAIMKAYKPDVVLGMGGYVSGPGGLAAWSLGIPVVLHEQNGIAGLTNKWLAKIATKVMQAFPGAFPNAEVVGNPVRTDVLALPLPQQRLAGREGPVRVLVVGGSQGARILNQTMPQVAAKLGDSVTIWHQSGKSSQQSVEQAYAEAGQPQHKVTEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPALFVPFQHKDRQQYWNALPLEKAGAAKIIEQPQLSVDAVANTLAGWSRETLLTMAERARAASIPDATERVANEVSRAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K14</accession>
    <name>Q32K14_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvH</name>
        <name evidence="10" type="ordered locus">SDY_0108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001252745.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401832.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K14"/>
    <dbReference type="STRING" id="300267.SDY_0108"/>
    <dbReference type="EnsemblBacteria" id="ABB60343">
        <property type="protein sequence ID" value="ABB60343"/>
        <property type="gene ID" value="SDY_0108"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0108"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.127"/>
    <dbReference type="HOGENOM" id="CLU_055003_1_3_6"/>
    <dbReference type="OMA" id="EPYGIKE"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="163" mass="18081" checksum="CC4289146585606E" modified="2005-12-06" version="1">MRRILSVLLENESGALSRVIGLFSQRGYNIESLTVAPTDDPTLSRMTIQTVGDEKVLEQIEKQLHKLVDVLRVSELGQGAHVEREIMLVKIQASGYGRDEVKRNTEIFRGQIIDVTPSLYTVQLAGTSDKLDAFLASIRDVAKIVEVARSGVVRLSRGDKIMC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q326N4</accession>
    <name>VIRA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Cysteine protease-like VirA</fullName>
            <ecNumber>3.4.22.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Effector protein VirA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">virA</name>
        <name type="ordered locus">SDY_P211</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid">
        <name>pSD1_197</name>
    </geneLocation>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles. The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks. Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure. This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell. Is absolutely required for virulence.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Interacts specifically with alpha tubulin, a major component of microtubule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
        <text evidence="1">Translocated into the host cell via the type III secretion system (TTSS). Localizes in the cytoplasm of the infected cell (By similarity).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protease EspG/VirA family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-"/>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001195011.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406212.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326N4"/>
    <dbReference type="SMR" id="Q326N4"/>
    <dbReference type="EnsemblBacteria" id="ABB64724">
        <property type="protein sequence ID" value="ABB64724"/>
        <property type="gene ID" value="SDY_P211"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P211"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5765"/>
    <dbReference type="HOGENOM" id="CLU_688663_0_0_6"/>
    <dbReference type="OMA" id="KCEIDEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009669">
        <property type="entry name" value="Cys_protease_VirA/EspG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043098">
        <property type="entry name" value="Cys_protease_VirA/EspG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06872">
        <property type="entry name" value="EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011515">
        <property type="entry name" value="EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0614">Plasmid</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0788">Thiol protease</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000297843" description="Cysteine protease-like VirA">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tubulin-binding domain" evidence="1">
        <location>
            <begin position="224"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="400" mass="44723" checksum="B02250769B731B39" modified="2005-12-06" version="1">MQTSNITNYERNDSSWMSTVKSTTEVSWNKLSFCDVLLKIITFGIYSPHETLAEKYSEKKLMDSFSPSLSQDKMDGEFAHANIDGISIRLCLNKGICSVFYLDGDKIQSTQLSSKEYNNLLSSLPPKQFNLGKVHTITAPVSGNFKTHKPAPEVIETAINCCTSIIPNDDYFSVKDTDFNSVWHDIYRDIRASDSNSTKIYFNNIEIPLKLIADLINELGINEFIDSKKELQMLSYNQVNKIINSNFPQQDLCFQTEKLLFTSLFQDPAFISALTSAFWQSLHITSSSVEHIYAQIMSENIENRLNFMPEQRVINNCGHIIKINAVVPKNDTAISASGGRAYEVSSSILPSHITCNGVGINKIETSYLVHAGTLPSSEGLRNAIPPESRQVSFAIISPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q326T4</accession>
    <name>Q326T4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VirB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">virB</name>
        <name evidence="3" type="ordered locus">SDY_P161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000227976.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406162.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326T4"/>
    <dbReference type="SMR" id="Q326T4"/>
    <dbReference type="EnsemblBacteria" id="ABB64674">
        <property type="protein sequence ID" value="ABB64674"/>
        <property type="gene ID" value="SDY_P161"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P161"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5720"/>
    <dbReference type="HOGENOM" id="CLU_065144_0_0_6"/>
    <dbReference type="OMA" id="CIDANEG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014884">
        <property type="entry name" value="ParB_fam_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08775">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="39"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="309" mass="35408" checksum="AD5FEEBEBFF6C0C4" modified="2005-12-06" version="1">MVDLCNDLLSIKEGQKKEFTLHSGNKVSFIKAKIPHKRIQDLTFVNQKTNVRDQESLTEESLADIIKTIKLQQFFPVIGREIDGRIEILDGTRRRASAIYAGADLEVLYSKEYISTLDARKLANDIQTAKEHSIRELGIGLNFLKVSGMSYKDIAKKENLSRAKVTRAFQAASVPQEIISLFPIASELNFNDYKILFNYYKGLEKANESLSSTLPILKEEIKDLDTNLPPDIYKKEILNIIKKSKNRKQNPSLKVDSLFISKDKRTYIKRKENKTNRTLIFTLSKINKTVQREIDEAIRDIISRHLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Z7</accession>
    <name>Q326Z7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406099.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Z7"/>
    <dbReference type="EnsemblBacteria" id="ABB64611">
        <property type="protein sequence ID" value="ABB64611"/>
        <property type="gene ID" value="SDY_P098"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P098"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5650"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15390" checksum="120534E1813DE26A" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFLRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q327E8</accession>
    <name>Q327E8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406048.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327E8"/>
    <dbReference type="EnsemblBacteria" id="ABB64560">
        <property type="protein sequence ID" value="ABB64560"/>
        <property type="gene ID" value="SDY_P047"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P047"/>
    <dbReference type="HOGENOM" id="CLU_185338_0_0_6"/>
    <dbReference type="OMA" id="NTYSTDW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="94" mass="11189" checksum="B7AA9FD665680BAF" modified="2005-12-06" version="1">MCGMRSLHFNSVTPSATKDKQVTRKGIFIQHMLYLERNNLPLRTRIKRLARKTICFSRSVEIHEKSSAPSLKNTYSTDWKRHPKKYRFFTVNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q327J9</accession>
    <name>Q327J9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Right origin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rob</name>
        <name evidence="3" type="ordered locus">SDY_4657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000371661.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405997.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327J9"/>
    <dbReference type="STRING" id="300267.SDY_4657"/>
    <dbReference type="EnsemblBacteria" id="ABB64506">
        <property type="protein sequence ID" value="ABB64506"/>
        <property type="gene ID" value="SDY_4657"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4657"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5519"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_1_6"/>
    <dbReference type="OMA" id="WRQYLGE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="289" mass="33127" checksum="1062B4E55C5512AB" modified="2005-12-06" version="1">MDQAGIIRDLLIWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKSAVALRLTARPILDIALQYRFDSQQTFTRAFKKQFAQTPALYRRSPEWSAFGIRPPLRLGEFTIPEHKFVTLEDTPLIGVTQSYSCSLEQISDFRHEMRYQFWHDFLGNAPTIPPVLYGLNETRPSQDKDDEQEVFYTTALAQDQADGYVLTGHPVMLQGGEYVMFTYEGLGTGVQEFILTVYGTCMPMLNLTRRKGQDIERYYPAEDAKAGDRPINLRCELLIPIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q327K5</accession>
    <name>Q327K5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable nadAB transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nadR</name>
        <name evidence="3" type="ordered locus">SDY_4651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327K5"/>
    <dbReference type="STRING" id="300267.SDY_4651"/>
    <dbReference type="EnsemblBacteria" id="ABB64500">
        <property type="protein sequence ID" value="ABB64500"/>
        <property type="gene ID" value="SDY_4651"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4651"/>
    <dbReference type="HOGENOM" id="CLU_052648_0_1_6"/>
    <dbReference type="OMA" id="QDPFRYW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050262">
        <property type="term" value="F:ribosylnicotinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02167">
        <property type="entry name" value="NMNAT_NadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016429">
        <property type="entry name" value="NAD_NadR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006417">
        <property type="entry name" value="NadR_NMN_Atrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041749">
        <property type="entry name" value="NMNAT_NadR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004776">
        <property type="entry name" value="NadR_NMNAT/RNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01526">
        <property type="entry name" value="nadR_NMN_Atrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="77"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="266"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004776-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="417" mass="48048" checksum="27D324472C26E52E" modified="2005-12-06" version="1">MRDTEGDMPSFDYLKTAIKQQGCTLQQVADASGMTKGYLSQLLNAKIKSPSAQKLEALHRFLGLEFPRQKKTIGVVFGKFYPLHTGHIYLIQRACSQVDELHIIMGFDDTRDRALFEDSAMSQQPTVPDRLRWLLQTFKYQKNIRIHAFNEEGMEPYPHGWDVWSNGIKKFMAEKGIQPDLIYTSEEADAPQYMEHLGIETVLVDPKRTFMSISGAQIRENPFRYWEYIPTEVKPFFVRTVAILGGESSGKSTLVNKLANIFNTTSAWEYGRDYVFSHLGGDEIALQYSDYDKIALGHAQYIDFAVKYANKVAFIDTDFVTTQAFCKKYEGREHPFVQALIDEYRFDLVILLENNTPWVADGLRSLGSSVDRKEFQNLLVEMLEENNIEFVRVEEDDYDSRFLRCVELVREMMGEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q327K7</accession>
    <name>Q327K7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">serB</name>
        <name evidence="16" type="ordered locus">SDY_4649</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-D-serine = D-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58680"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-serine = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001132954.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405989.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327K7"/>
    <dbReference type="STRING" id="300267.SDY_4649"/>
    <dbReference type="EnsemblBacteria" id="ABB64498">
        <property type="protein sequence ID" value="ABB64498"/>
        <property type="gene ID" value="SDY_4649"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4649"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5511"/>
    <dbReference type="HOGENOM" id="CLU_036368_4_0_6"/>
    <dbReference type="OMA" id="CINEPDL"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041449">
        <property type="entry name" value="SerB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18429">
        <property type="entry name" value="DUF5609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="DUF5609" evidence="15">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB64498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="322" mass="35052" checksum="A08D73BD846B7DE6" modified="2005-12-06" version="1">MPNITWCDLPEDVSLWPGLPLSLSGDEVMPLDYHAGRSGWLLYGRGLDKQRLTQYQSKLGAAMVIVAAWCVEDYQVIRLAGSLTARATRLAHEAQLDVAPLGKIPHLRTPGLLVMDMDSTAIQIECIDEIAKLAGTGEMVAEVTERAMRGELDFTASLRSRVATLKGADANILQQVRENLPLMPGLTQLVLKLETLGWKVAIASGGFTFFAEYLRDKLRLTAVVANELEIMDGKFTGNVIGDIVDAQYKAKTLTRLAQEYEIPLAQTVAIGDGANDLPMIKAAGLGIAYHAKPKVNEKAEVTIRHADLMGVFCILSGSLNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q327S7</accession>
    <name>Q327S7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yhjV</name>
        <name evidence="8" type="ordered locus">SDY_4562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378975.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405919.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327S7"/>
    <dbReference type="STRING" id="300267.SDY_4562"/>
    <dbReference type="EnsemblBacteria" id="ABB64428">
        <property type="protein sequence ID" value="ABB64428"/>
        <property type="gene ID" value="SDY_4562"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4562"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5400"/>
    <dbReference type="HOGENOM" id="CLU_052043_3_0_6"/>
    <dbReference type="OMA" id="NWVYSFL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018227">
        <property type="entry name" value="Amino_acid_transport_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03222">
        <property type="entry name" value="Trp_Tyr_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="423" mass="47265" checksum="9DCCE2B6B9EF1EA9" modified="2005-12-06" version="1">MQHNTLPKHDQKLPFTRYDFGWVLLCIGMAIGAGTVLMPVQIGLKGIWVFITAAIIAYPATWVVQDIYLKTLSESDSCNDYTDIISHYLGKNWGIFLGVIYFLMIIHGIFIYSLSVVFDSASYLKTFGLTDADLSQSLLYKVAIFAVLVAIASGGERLLFKISGPMVVVKVGIIVVFGFAMIPHWNFANITAFPQASVFFRDVLLTIPFCFFSAVFIQVLNPMNIAYRKREADKVLATRLALRTHRISYITLIAVILFFAFSFTFSISHEEAVSAFEQNISALALAAQVIPGHIIHITSTVLNIFAVLTAFFGIYLGFHEAIKGIILNLLSRIIDTKKINSRVLTLAICTFIVITLTIWVSFRVSVLVFFQLGSPLYGIVSCLIPFLLIYKVAQLEKLRGFKAWLILLYGILLCLSPLLKLIE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q328B8</accession>
    <name>MSRA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="1">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="1">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="1">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msrA</name>
        <name type="ordered locus">SDY_4456</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021358.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405828.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328B8"/>
    <dbReference type="SMR" id="Q328B8"/>
    <dbReference type="STRING" id="300267.SDY_4456"/>
    <dbReference type="EnsemblBacteria" id="ABB64337">
        <property type="protein sequence ID" value="ABB64337"/>
        <property type="gene ID" value="SDY_4456"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4456"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5257"/>
    <dbReference type="HOGENOM" id="CLU_031040_10_3_6"/>
    <dbReference type="OMA" id="AGPFYYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000068360" description="Peptide methionine sulfoxide reductase MsrA">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <sequence length="212" mass="23378" checksum="585AD43136C68E71" modified="2005-12-06" version="1">MSLFDKKHLVSPADALPGRNTPMPVATLHAVNGHSMTNVPDGMEIAIFAMGCFWGVERLFWQLPSVYSTAAGYTGGYTPNPTYREVCSGDTGHAEAVRIVYDPSVISYEQLLQIFWENHDPAQGMRQGNDHGTQYRSAIYPLTPEQDAAARASLERFQAAMLAADDDRRITTEIANATPFYYAEDDHQQYLHKNPYGYCGIGGIGVCLPPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q328F8</accession>
    <name>Q328F8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease R</fullName>
            <shortName evidence="6">RNase R</shortName>
            <ecNumber evidence="6">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">vacB</name>
        <name evidence="6" type="synonym">rnr</name>
        <name evidence="9" type="ordered locus">SDY_4410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328F8"/>
    <dbReference type="STRING" id="300267.SDY_4410"/>
    <dbReference type="EnsemblBacteria" id="ABB64297">
        <property type="protein sequence ID" value="ABB64297"/>
        <property type="gene ID" value="SDY_4410"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4410"/>
    <dbReference type="HOGENOM" id="CLU_002333_7_0_6"/>
    <dbReference type="OMA" id="DWYEYRS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013668">
        <property type="entry name" value="RNase_R_HTH_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08461">
        <property type="entry name" value="HTH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="658"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="745"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="823" mass="93340" checksum="DC8AD3F4CF504A10" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q328I2</accession>
    <name>Q328I2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_3883</name>
        <name evidence="4" type="ordered locus">SDY_4386</name>
        <name evidence="5" type="ordered locus">SDY_4512</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000780.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405314.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405764.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405878.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63823">
        <property type="protein sequence ID" value="ABB63823"/>
        <property type="gene ID" value="SDY_3883"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64273">
        <property type="protein sequence ID" value="ABB64273"/>
        <property type="gene ID" value="SDY_4386"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64387">
        <property type="protein sequence ID" value="ABB64387"/>
        <property type="gene ID" value="SDY_4512"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3883"/>
    <dbReference type="KEGG" id="sdy:SDY_4386"/>
    <dbReference type="KEGG" id="sdy:SDY_4512"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4596"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14990" checksum="027B3A5DF6C0E8A0" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRFRKTVVAHVFGERTMATLGRLMSLLLPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q328P5</accession>
    <name>Q328P5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sorbose-permease PTS system IIC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_4315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000406321.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405701.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328P5"/>
    <dbReference type="STRING" id="300267.SDY_4315"/>
    <dbReference type="EnsemblBacteria" id="ABB64210">
        <property type="protein sequence ID" value="ABB64210"/>
        <property type="gene ID" value="SDY_4315"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4315"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5092"/>
    <dbReference type="HOGENOM" id="CLU_069101_0_0_6"/>
    <dbReference type="OMA" id="DWIHVSA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004700">
        <property type="entry name" value="PTS_IIC_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03609">
        <property type="entry name" value="EII-Sor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00822">
        <property type="entry name" value="EII-Sor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51106">
        <property type="entry name" value="PTS_EIIC_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="265" mass="27942" checksum="59B11FAE2329A53E" modified="2005-12-06" version="1">MEISTLQIIAIFLFSCIAGMGSVLDEFQTHRPLIACTVIGLILGDLKTGIILGGTLELIALGWMNVGAAQSPDSALASIISAILVIVGQQSIATGIAIALPVAAAGQVLTVFARTITVVFQHAADKAAEEARFRTLDILHVSALGVQALRVAVPALIVSLFVSADMVSNMLNAIPEFVTRGLQIAGGFIVVVGYAMVLRMMGVKYLMPFFFLGFLAGGYLDLSLLAFGGVGVIMALIYIQLNPQWRKAEPQLQAPASTALDQLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Q7</accession>
    <name>Q328Q7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_2103</name>
        <name evidence="9" type="ordered locus">SDY_4302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403685.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405689.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_2103"/>
    <dbReference type="EnsemblBacteria" id="ABB62194">
        <property type="protein sequence ID" value="ABB62194"/>
        <property type="gene ID" value="SDY_2103"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64198">
        <property type="protein sequence ID" value="ABB64198"/>
        <property type="gene ID" value="SDY_4302"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2103"/>
    <dbReference type="KEGG" id="sdy:SDY_4302"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2532"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="OMA" id="MNDGSEQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="9911" checksum="895F41CEDBC8F4B0" modified="2005-12-06" version="1">MASISIRCPSCSATEGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGKHQKIIDMAMNGVGCRASARIMGVGLNTVLRHLKNSGCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q328T7</accession>
    <name>Q328T7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjgI</name>
        <name evidence="1" type="ordered locus">SDY_4267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000500707.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405659.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328T7"/>
    <dbReference type="STRING" id="300267.SDY_4267"/>
    <dbReference type="EnsemblBacteria" id="ABB64168">
        <property type="protein sequence ID" value="ABB64168"/>
        <property type="gene ID" value="SDY_4267"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4267"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5029"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_6"/>
    <dbReference type="OMA" id="QANLMTI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="24545" checksum="094148A2043936D0" modified="2005-12-06" version="1">MGAFTGKTVLILGGSRGIGAAIVRRFVTDGANVRFTYAGSKDAAERLAQETGATAVFTDSADRDAVIDVVRKSGALDILVVNAGIGVFGDALELNADDIDRLFKINIHAPYHASVEAARQMAEGGRILIIGSVNGDRMPVAGMAAYAASKSALQGMARGLARDFGPRGITINVVQPGPIDTDANPANGPIRDMLHGFMAIKRHGQPEEVAGMVAWLAGPEASFVTGAMHTIDGAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q329C0</accession>
    <name>Q329C0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidB</name>
        <name evidence="1" type="ordered locus">SDY_4180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000522209.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405576.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329C0"/>
    <dbReference type="STRING" id="300267.SDY_4180"/>
    <dbReference type="EnsemblBacteria" id="ABB64085">
        <property type="protein sequence ID" value="ABB64085"/>
        <property type="gene ID" value="SDY_4180"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4180"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4917"/>
    <dbReference type="HOGENOM" id="CLU_084747_5_0_6"/>
    <dbReference type="OMA" id="WVSTGQN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045372">
        <property type="entry name" value="YidB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027405">
        <property type="entry name" value="YidB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20159">
        <property type="entry name" value="YidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140804">
        <property type="entry name" value="SSF140804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="132" mass="13803" checksum="92D74D2D126BB4B4" modified="2005-12-06" version="1">MGLFDEVVGAFLKGDAGKYQAILSWVEEQGGIQVLLEKLQSGGLGAILSTWLSNQQGNQSVSGEQLESALGTNAVSDLGQKLGVDTSTASSLLAEQLPKIIDALSPQGEVSPQANNDLLSSGMELLKGKLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q329F1</accession>
    <name>Q329F1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yicN</name>
        <name evidence="2" type="ordered locus">SDY_4144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405545.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329F1"/>
    <dbReference type="STRING" id="300267.SDY_4144"/>
    <dbReference type="EnsemblBacteria" id="ABB64054">
        <property type="protein sequence ID" value="ABB64054"/>
        <property type="gene ID" value="SDY_4144"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4144"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4871"/>
    <dbReference type="HOGENOM" id="CLU_145987_0_0_6"/>
    <dbReference type="OMA" id="ERPNEAH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009587">
        <property type="entry name" value="DUF1198"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06711">
        <property type="entry name" value="DUF1198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="159" mass="18173" checksum="FDD8730108516CA9" modified="2005-12-06" version="1">MSSDYAGELMIWIMLATLAVVFVVGFRVLTSGARKAIRRLSDRLNIDVVPVESMVDQMGKSAGDEFLRYLHRPDESHLQNAAQVLLIWQIVIVDGSEQNLLQWHRILQKARLAAPITDAQVRLALGFLRETEPEMQDINAFQMRYNAFFQPAEGVHWLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q329K6</accession>
    <name>Q329K6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase</fullName>
            <ecNumber evidence="3">3.1.7.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">spoT</name>
        <name evidence="8" type="ordered locus">SDY_4082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:77828"/>
            <dbReference type="EC" id="3.1.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GDP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="3.1.7.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000280491.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405490.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329K6"/>
    <dbReference type="STRING" id="300267.SDY_4082"/>
    <dbReference type="EnsemblBacteria" id="ABB63999">
        <property type="protein sequence ID" value="ABB63999"/>
        <property type="gene ID" value="SDY_4082"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4082"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4803"/>
    <dbReference type="HOGENOM" id="CLU_012300_3_0_6"/>
    <dbReference type="OMA" id="DWISSPK"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="45"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="386"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="628"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="702" mass="79319" checksum="77B1EA6B11245342" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q329N5</accession>
    <name>Q329N5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose--lps heptosyltransferase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfaF</name>
        <name evidence="2" type="ordered locus">SDY_4052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000699219.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405461.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329N5"/>
    <dbReference type="SMR" id="Q329N5"/>
    <dbReference type="STRING" id="300267.SDY_4052"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63970">
        <property type="protein sequence ID" value="ABB63970"/>
        <property type="gene ID" value="SDY_4052"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4052"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4768"/>
    <dbReference type="HOGENOM" id="CLU_038371_7_0_6"/>
    <dbReference type="OMA" id="GSAKRWP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011910">
        <property type="entry name" value="RfaF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02195">
        <property type="entry name" value="heptsyl_trn_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="348" mass="39042" checksum="C5F57BC94B15BA6A" modified="2005-12-06" version="1">MKILVIGPSWVGDMMMSQSLYRTLQARYPQAIIDVMAPAWCRPLLSRMPEVNEAIPMPLGHGALEIGERRKLGHSLREKRYDRAYVLPNSFKSALVPFFAGIPHRTGWRGEMRYGLLNDVRVLDKEAWPLMVERYIALAYDKGIMRTAQDLPQPLLWPQLQVSEGEKSYTCNQFSLSSERPMIGFCPGAEFGPAKRWPHYHYAELAKQLIDEGYQVVLFGSAKDHEAGNEILAALNTEQQAWCRNLAGETQLDQAVILIAACKAIVTNDSGLMHVAAALNRPLVALYGPSSPDFTPPLSHKARVIRLITGYHKVRKGDAAEGYHQSLIDITPQRVLEELNALLLQEEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q329N8</accession>
    <name>TDH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-threonine 3-dehydrogenase</fullName>
            <shortName evidence="1">TDH</shortName>
            <ecNumber evidence="1">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tdh</name>
        <name type="ordered locus">SDY_4049</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000646020.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405458.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329N8"/>
    <dbReference type="SMR" id="Q329N8"/>
    <dbReference type="STRING" id="300267.SDY_4049"/>
    <dbReference type="EnsemblBacteria" id="ABB63967">
        <property type="protein sequence ID" value="ABB63967"/>
        <property type="gene ID" value="SDY_4049"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4049"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4765"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_6"/>
    <dbReference type="OMA" id="ETWYAMS"/>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00627">
        <property type="entry name" value="Thr_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00692">
        <property type="entry name" value="tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000051662" description="L-threonine 3-dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00627"/>
        </source>
    </evidence>
    <sequence length="341" mass="37169" checksum="354556FFA47BEDAE" modified="2005-12-06" version="1">MKALSKLKAEEGIWMTDVPVPELGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPGNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAAAVAKHVGARNVVITDVNEYRLELARKMGITRAANVAKENLNDVMAELGMTEGFDVGLEMSGAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDDFQKGFDAMRSGQSGKVILSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q329P0</accession>
    <name>Q329P0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yibQ</name>
        <name evidence="2" type="ordered locus">SDY_4047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405456.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329P0"/>
    <dbReference type="STRING" id="300267.SDY_4047"/>
    <dbReference type="EnsemblBacteria" id="ABB63965">
        <property type="protein sequence ID" value="ABB63965"/>
        <property type="gene ID" value="SDY_4047"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4047"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4763"/>
    <dbReference type="HOGENOM" id="CLU_041643_4_0_6"/>
    <dbReference type="OMA" id="VMLHMPM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10936">
        <property type="entry name" value="CE4_DAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006837">
        <property type="entry name" value="Divergent_DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30105">
        <property type="entry name" value="PTHR30105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04748">
        <property type="entry name" value="Polysacc_deac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="277" mass="30771" checksum="DD288AA19432CC53" modified="2005-12-06" version="1">MLAMPSAISVAVLPDSPHAREMATKAHNSGHEVLIHLPMAPLSKQPLEKNTLRPEMSSDEIERIIRSAVNNVPYAVGINNHMGSKMTSNLFGMQKVMQALERYNLYFLDSVTIGNTQAMRAAQGTGVKVIKRKVFLDDSQNEADIRVQFNRAIDLARRNGSTIAIGHPHPSTVRVLQQMVYNLPPDITLVKASSLLNEPQVDTSTPPKNTVPDTPRNPFRGVKLCKPKKPIEPVYANRFFEVLSESISQSTLIVYFQHQWQGWGKQPEAAKLNASAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q329P9</accession>
    <name>LLDD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lldD</name>
        <name type="ordered locus">SDY_4038</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-lactate + A = AH2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:45816"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000586955.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405447.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329P9"/>
    <dbReference type="SMR" id="Q329P9"/>
    <dbReference type="STRING" id="300267.SDY_4038"/>
    <dbReference type="EnsemblBacteria" id="ABB63956">
        <property type="protein sequence ID" value="ABB63956"/>
        <property type="gene ID" value="SDY_4038"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4038"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4753"/>
    <dbReference type="HOGENOM" id="CLU_020639_0_0_6"/>
    <dbReference type="OMA" id="FTRLMQT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004457">
        <property type="term" value="F:lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01559">
        <property type="entry name" value="L_lact_dehydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020920">
        <property type="entry name" value="LldD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000206349" description="L-lactate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01559"/>
        </source>
    </evidence>
    <sequence length="396" mass="42755" checksum="CA0D8E309BC27283" modified="2005-12-06" version="1">MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSLETTLFNEKLSMPVALAPVGLCGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMRRYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLGNNFDPSISWKDLEWIRDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIALGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMTLTGAKSINEITQDSLVQGLGKELPAALAPMAKGNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q329W2</accession>
    <name>Q329W2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Z5294 gene product</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405384.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329W2"/>
    <dbReference type="EnsemblBacteria" id="ABB63893">
        <property type="protein sequence ID" value="ABB63893"/>
        <property type="gene ID" value="SDY_3965"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3965"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4677"/>
    <dbReference type="HOGENOM" id="CLU_2710511_0_0_6"/>
    <dbReference type="OMA" id="WLIFAQY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8258" checksum="9B67DAA68E9D8004" modified="2005-12-06" version="1">MPKTPRVYVAFCFYICNLNAALAMLGKFLEFAGVLCNLHIKWLIFAQDWWVRNGLSLLNKGLRGYTSANNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Y1</accession>
    <name>Q329Y1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylate cyclase</fullName>
            <ecNumber evidence="4 11">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cyaA</name>
        <name evidence="14" type="ordered locus">SDY_3940</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenylyl cyclase class-1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4 11"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000281665.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405365.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Y1"/>
    <dbReference type="STRING" id="300267.SDY_3940"/>
    <dbReference type="EnsemblBacteria" id="ABB63874">
        <property type="protein sequence ID" value="ABB63874"/>
        <property type="gene ID" value="SDY_3940"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3940"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4651"/>
    <dbReference type="HOGENOM" id="CLU_013280_0_0_6"/>
    <dbReference type="OMA" id="YDDYVMS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000274">
        <property type="entry name" value="Adenylate_cyclase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024686">
        <property type="entry name" value="Adenylate_cyclase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024685">
        <property type="entry name" value="Adenylate_cyclase_1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38760">
        <property type="entry name" value="PTHR38760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12633">
        <property type="entry name" value="Adenyl_cycl_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01295">
        <property type="entry name" value="Adenylate_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001444">
        <property type="entry name" value="Adenylate_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01092">
        <property type="entry name" value="ADENYLATE_CYCLASE_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01093">
        <property type="entry name" value="ADENYLATE_CYCLASE_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenyl_cycl_N" evidence="13">
        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB63874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="848" mass="97507" checksum="C2FC4CD03852D3E9" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Z7</accession>
    <name>Q329Z7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rarD</name>
        <name evidence="10" type="ordered locus">SDY_3924</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000339096.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405349.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Z7"/>
    <dbReference type="STRING" id="300267.SDY_3924"/>
    <dbReference type="EnsemblBacteria" id="ABB63858">
        <property type="protein sequence ID" value="ABB63858"/>
        <property type="gene ID" value="SDY_3924"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3924"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4632"/>
    <dbReference type="HOGENOM" id="CLU_054508_1_0_6"/>
    <dbReference type="OMA" id="HRMVWSL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="297" mass="33366" checksum="817D38F01B5D307B" modified="2005-12-06" version="1">MDAKQTRQGVLLALAAYFIWGIAPAYFKLIYYVPADEILTHRVIWSFFFMVVLMSICRQWSYLKTLIQTPQKIFMLAVSAVLIGGNWLLFIWAVNNHHMLEASLGYFINPLVNIVLGMIFLGERFRRMQWLAVILAICGVLVQLWTFGSLPIIALGLAFSFAFYGLVRKKIAVEAQTGMLIETMWLLPVAAIYLFAIADSSTSHMGQNPISLNLLLIAAGIVTTVPLLCFTAAATTRLRLSTLGFFQYIGPTLMFLLAVTFYGEKPGADKMVTFAFIWVALAIFVMDAIYTQRRTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A27</accession>
    <name>Q32A27_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">mobA</name>
        <name evidence="6" type="ordered locus">SDY_3888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001052158.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405319.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A27"/>
    <dbReference type="STRING" id="300267.SDY_3888"/>
    <dbReference type="EnsemblBacteria" id="ABB63828">
        <property type="protein sequence ID" value="ABB63828"/>
        <property type="gene ID" value="SDY_3888"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3888"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4601"/>
    <dbReference type="HOGENOM" id="CLU_055597_5_1_6"/>
    <dbReference type="OMA" id="IDFWYAK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02665">
        <property type="entry name" value="molyb_mobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="194" mass="21670" checksum="F3E6AADEC6ACE315" modified="2005-12-06" version="1">MNLMTTITGVVLAGGKARRMGGVDKGLLDLNGKPLWQHVADALMTQLSHVVVNANRHQEIYQAGGLKVIEDSLADYPGPLAGMLSVMQQEAGEWFLFCPCDTPYIPHDLAARLNHQRKDAPVVWVHDGERDHPTIALVNRTIEPLLLEYLQAGERRVMAFMRLAGGHAVDFSNHKDAFVNVNTPEELTRWQEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AG5</accession>
    <name>Q32AG5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamin biosynthesis, thiazole moiety</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiF</name>
        <name evidence="6" type="ordered locus">SDY_3734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AG5"/>
    <dbReference type="STRING" id="300267.SDY_3734"/>
    <dbReference type="EnsemblBacteria" id="ABB63690">
        <property type="protein sequence ID" value="ABB63690"/>
        <property type="gene ID" value="SDY_3734"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3734"/>
    <dbReference type="HOGENOM" id="CLU_013325_10_3_6"/>
    <dbReference type="OMA" id="SAKWKLE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012731">
        <property type="entry name" value="Adenyl_ThiF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02356">
        <property type="entry name" value="adenyl_thiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ThiF" evidence="5">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl persulfide ester intermediate" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl cysteine dithioester (Cys-Gly) (interchain with G-Cter in ThiS)" evidence="4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR612731-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR612731-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR612731-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR612731-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="245" mass="26163" checksum="79D088D351630C8B" modified="2005-12-06" version="1">MRYSRQILLDDIALDGQQKLLDSQVLIIGLGGLGTPAALYLAGAGVGTLVLADDDDVHLSNLQRQILFTTEDIDRPKSQVSQQRLTQLNPDIQLTALQQRLTGEALKDAVAQADVVLDCTDNMATRQEINAACVALNTPLITASAVGFGGQLMVLTPPWEQGCYRCLWPDNQEPERNCRTAGVVGPVVGVMGTLQALEAIKLLSGIETPAGELRLFDGKSSQWRSLALRRASGCPVCGGSNADPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AH4</accession>
    <name>Q32AH4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjaH</name>
        <name evidence="1" type="ordered locus">SDY_3725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001300651.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405172.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AH4"/>
    <dbReference type="STRING" id="300267.SDY_3725"/>
    <dbReference type="EnsemblBacteria" id="ABB63681">
        <property type="protein sequence ID" value="ABB63681"/>
        <property type="gene ID" value="SDY_3725"/>
    </dbReference>
    <dbReference type="GeneID" id="66672087"/>
    <dbReference type="KEGG" id="sdy:SDY_3725"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4417"/>
    <dbReference type="HOGENOM" id="CLU_112915_0_0_6"/>
    <dbReference type="OMA" id="FMQREVD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010858">
        <property type="entry name" value="DUF1481"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016500">
        <property type="entry name" value="UCP006993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07356">
        <property type="entry name" value="DUF1481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006993">
        <property type="entry name" value="UCP006993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="231" mass="26351" checksum="46E892372DD65C63" modified="2005-12-06" version="1">MNSFNEGVVSPLLSFWRRSLMLAGALFLTACSHNSSLPPFTASGFAEDQGAVRIWRKDSGDNVHLLAVFSPWRSGDTTTREYRWQGDNLTLININVYSKPPVNIRARFDDRGDLSFMQRESDGEKQQLSNDQIDLYRYRADQIRQISDALRQGRVVLRQGRWHAMEQTVTTCEGQTIKPDLDSQAIAHIERRQSRSSVDVSVAWLEAPEGSQLLLVANSDFCRWQPNEKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AP5</accession>
    <name>Q32AP5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative phosphotransferase system enzyme IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_3642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000084022.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405101.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AP5"/>
    <dbReference type="STRING" id="300267.SDY_3642"/>
    <dbReference type="EnsemblBacteria" id="ABB63610">
        <property type="protein sequence ID" value="ABB63610"/>
        <property type="gene ID" value="SDY_3642"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3642"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4324"/>
    <dbReference type="HOGENOM" id="CLU_159248_3_1_6"/>
    <dbReference type="OMA" id="VNIIQCK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-2" evidence="4">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="93" mass="9808" checksum="E86260B93DF93AA5" modified="2005-12-06" version="1">MSQTILFVCATGIATSTAVTEKVMEYCKEHGLNVNYSQTNVASLPGNTDGVALVVSTTKVPYELDVPVVNGLPIITGIGEEKVLAQIVSILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AR7</accession>
    <name>Q32AR7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhhL</name>
        <name evidence="2" type="ordered locus">SDY_3617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295207.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405079.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AR7"/>
    <dbReference type="STRING" id="300267.SDY_3617"/>
    <dbReference type="EnsemblBacteria" id="ABB63588">
        <property type="protein sequence ID" value="ABB63588"/>
        <property type="gene ID" value="SDY_3617"/>
    </dbReference>
    <dbReference type="GeneID" id="66672650"/>
    <dbReference type="KEGG" id="sdy:SDY_3617"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4293"/>
    <dbReference type="HOGENOM" id="CLU_159241_0_0_6"/>
    <dbReference type="OMA" id="FGITCMM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009525">
        <property type="entry name" value="DUF1145"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38775">
        <property type="entry name" value="PTHR38775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06611">
        <property type="entry name" value="DUF1145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="89" mass="10280" checksum="699EB5F1337BA4A2" modified="2005-12-06" version="1">MLINIGRLLMLCVWGFLILNLVHPFPRPLNIFVNVALIFTVLMHGMQLALLKSTLPKDGPQMTTAEKVRIFLFGVFELLVWQKKFKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B07</accession>
    <name>Q32B07_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine/succinyldiaminopimelate aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <shortName evidence="2">DapATase</shortName>
            <shortName evidence="2">Succinyldiaminopimelate transferase</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
            <ecNumber evidence="2">2.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">argD</name>
        <name evidence="2" type="synonym">dapC</name>
        <name evidence="4" type="ordered locus">SDY_3521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in both the arginine and lysine biosynthetic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11960"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58087"/>
            <dbReference type="EC" id="2.6.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EC" id="2.6.1.17" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000963778.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404989.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B07"/>
    <dbReference type="STRING" id="300267.SDY_3521"/>
    <dbReference type="EnsemblBacteria" id="ABB63498">
        <property type="protein sequence ID" value="ABB63498"/>
        <property type="gene ID" value="SDY_3521"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3521"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4176"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_6"/>
    <dbReference type="OMA" id="KYSSDYA"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00020"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009016">
        <property type="term" value="F:succinyldiaminopimelate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017652">
        <property type="entry name" value="Ac/SucOrn_transaminase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03246">
        <property type="entry name" value="arg_catab_astC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="226"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="406" mass="43839" checksum="5E23BFC9C28A9463" modified="2005-12-06" version="1">MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVMAATPEFLQGLRELCDQYQALLVFDEVQCGMGRTGDLFVYMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHLGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGQARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVAKVVGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B92</accession>
    <name>NTPPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="1">dTTPase/UTPase</shortName>
            <ecNumber evidence="1">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="1">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">yceF</name>
        <name type="ordered locus">SDY_3423</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000203088.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404904.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B92"/>
    <dbReference type="SMR" id="Q32B92"/>
    <dbReference type="STRING" id="300267.SDY_3423"/>
    <dbReference type="EnsemblBacteria" id="ABB63413">
        <property type="protein sequence ID" value="ABB63413"/>
        <property type="gene ID" value="SDY_3423"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3423"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4081"/>
    <dbReference type="HOGENOM" id="CLU_040416_2_1_6"/>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000267433" description="dTTP/UTP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <sequence length="197" mass="21376" checksum="26ED2DF88502296F" modified="2005-12-06" version="1">MTSLYLASGSPRRQELLAQLGVTFERIVTGIEEQRQPQESAQQYVVRLACEKAQAGVAQTAQDLPVLGADTIVILNGEVLEKPRDAEHAAQMLRKLSGQTHQVMTAVALADSQHILDCLVVTDVTFRTLTDEDIAGYVASGEPLDKAGAYGIQGLGGCFVRKINGSYHAVVGLPLVETYELLSNFNALREKRDKHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BA4</accession>
    <name>Q32BA4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase Do</fullName>
            <ecNumber evidence="3">3.4.21.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">degS</name>
        <name evidence="7" type="ordered locus">SDY_3411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.</text>
            <dbReference type="EC" id="3.4.21.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000497723.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404892.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BA4"/>
    <dbReference type="SMR" id="Q32BA4"/>
    <dbReference type="STRING" id="300267.SDY_3411"/>
    <dbReference type="MEROPS" id="S01.275"/>
    <dbReference type="EnsemblBacteria" id="ABB63401">
        <property type="protein sequence ID" value="ABB63401"/>
        <property type="gene ID" value="SDY_3411"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3411"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4069"/>
    <dbReference type="HOGENOM" id="CLU_020120_2_2_6"/>
    <dbReference type="OMA" id="THGWVLE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011783">
        <property type="entry name" value="Pept_S1C_DegS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02038">
        <property type="entry name" value="protease_degS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="281"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="259"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611783-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611783-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="355" mass="37581" checksum="D091B4D65E8FE1CC" modified="2005-12-06" version="1">MFVKLLRSVAIGLIVGAILLVAMPSLRSLNPLSTPQFDSTDETPASYNLAVRRAAPAVVNVYNRGLNTNSHNQLEIRTLGSGVIMDQRGYIITNKHVINDADQIIVALQDGRVFEALLVGSDSLTDLAVLKINATGGLPTIPINARRVPHIGDVVLAIGNPYNLGQTITQGIISATGRIGLNPTGRQNFLQTDASINHGNSGGALVNSLGELMGINTLSFDKSNDGETPEGIGFAIPFQLATKIMDKLIRDGRVIRGYIGIGGREIAPLHAQGGGIDQLQGIVVNEVSPDGPAANAGIQVNDLIISVDNKPAISALETMDQVAEIRPGSVIPVVVMRDDKQLTLQVTIQEYPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BH0</accession>
    <name>Q32BH0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Lipoprotein NlpI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhbM</name>
        <name evidence="6" type="ordered locus">SDY_3342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000802086.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404826.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BH0"/>
    <dbReference type="STRING" id="300267.SDY_3342"/>
    <dbReference type="EnsemblBacteria" id="ABB63335">
        <property type="protein sequence ID" value="ABB63335"/>
        <property type="gene ID" value="SDY_3342"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3342"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3996"/>
    <dbReference type="HOGENOM" id="CLU_071600_0_0_6"/>
    <dbReference type="OMA" id="VEHRYSF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023605">
        <property type="entry name" value="Lipoprotein_NlpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004654">
        <property type="entry name" value="NlpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR004654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="294" mass="33597" checksum="EB819830609DBDA7" modified="2005-12-06" version="1">MKPFLRWCFVATALTLAGCSNTSWRKSEVLAVPLQPTLQQEVILARMEQILASRALTDDERAQLLYERGVLYDSLGLRALARNDFSQALAIRPDMPEVFNYLGIYLTQAGNFDAAYEAFDSVLELDPTYNYAHLNRGIALYYGGRDKLAQDDLLAFYQDDPNDPFRSLWLYLAEQKLDEKQAKEVLKQNFEKSDKEQWGWNIVEFYLGNISKQTLMERLKADATDNTSLAEHLSETNFYLGKYYLSLGDLDSATALFKLAVANNVHNFVEHRYALLELSLLGQDQDDLAESDQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-11-04" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BJ0</accession>
    <name>GARL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-keto-4-deoxy-D-glucarate aldolase</fullName>
            <shortName evidence="1">KDGluc aldolase</shortName>
            <shortName evidence="1">KDGlucA</shortName>
            <ecNumber evidence="1">4.1.2.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-dehydro-3-deoxy-D-glucarate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-keto-3-deoxy-D-glucarate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">5-dehydro-4-deoxy-D-glucarate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Alpha-keto-beta-deoxy-D-glucarate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">garL</name>
        <name type="ordered locus">SDY_3320</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:27726"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:42819"/>
            <dbReference type="ChEBI" id="CHEBI:57978"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:10268"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57978"/>
            <dbReference type="ChEBI" id="CHEBI:58098"/>
            <dbReference type="EC" id="4.1.2.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate acid metabolism; galactarate degradation; D-glycerate from galactarate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001058222.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404806.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BJ0"/>
    <dbReference type="SMR" id="Q32BJ0"/>
    <dbReference type="STRING" id="300267.SDY_3320"/>
    <dbReference type="EnsemblBacteria" id="ABB63315">
        <property type="protein sequence ID" value="ABB63315"/>
        <property type="gene ID" value="SDY_3320"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3320"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3972"/>
    <dbReference type="HOGENOM" id="CLU_059964_1_0_6"/>
    <dbReference type="OMA" id="NEGWMVK"/>
    <dbReference type="UniPathway" id="UPA00565">
        <property type="reaction ID" value="UER00630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008672">
        <property type="term" value="F:2-dehydro-3-deoxyglucarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042838">
        <property type="term" value="P:D-glucarate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046392">
        <property type="term" value="P:galactarate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01291">
        <property type="entry name" value="KDGluc_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017648">
        <property type="entry name" value="GarL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03239">
        <property type="entry name" value="GarL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000353161" description="5-keto-4-deoxy-D-glucarate aldolase">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="site" description="Increases basicity of active site His" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01291"/>
        </source>
    </evidence>
    <sequence length="256" mass="27341" checksum="A363593FFF575001" modified="2005-12-06" version="1">MNNDVFPNKFKAALAAKQVQIGCWSALSNPISTEVLGLAGFDWLVLDGEHAPNDISTFIPQLMALKGSASAPVVRVPTNEPVIIKRLLDIGFYNFLIPFVETKEEAEQAVASTRYPPEGIRGVSVSHRANMFGTVADYFAQSNKNITILVQIESQQGVDNVDAIAATEGVDGIFVGPSDLAAALGHLGNASHPDVQKAIQHIFNRASAHGKPSGILAPVEADARRYLAWGATFVAVGSDLGVFRSATQKLADTFKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BK8</accession>
    <name>YHAM_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0597 protein YhaM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yhaM</name>
        <name type="ordered locus">SDY_3300</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0597 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000460540.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404788.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BK8"/>
    <dbReference type="SMR" id="Q32BK8"/>
    <dbReference type="STRING" id="300267.SDY_3300"/>
    <dbReference type="EnsemblBacteria" id="ABB63297">
        <property type="protein sequence ID" value="ABB63297"/>
        <property type="gene ID" value="SDY_3300"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3300"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3945"/>
    <dbReference type="HOGENOM" id="CLU_051840_0_0_6"/>
    <dbReference type="OMA" id="GAMIPVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01845">
        <property type="entry name" value="UPF0597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021144">
        <property type="entry name" value="UPF0597"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30501">
        <property type="entry name" value="PTHR30501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006054">
        <property type="entry name" value="UCP006054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000339858" description="UPF0597 protein YhaM">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01845"/>
        </source>
    </evidence>
    <sequence length="436" mass="45405" checksum="FDEECEEB85B53F4F" modified="2005-12-06" version="1">MFDSTLNPLWQRYILAVQEEVKPALGCTEPISLALAASVAAAELEGPVERVEAWVSPNLMKNGLGVTVPGTGMVGLPIAAALGALGGNANAGLEVLKDATAQAIADAKALLAAGKVSVKIQEPCNEILFSRAKVWNGEKWACVTIVGGHTNIVHIETHDGVVFTQQACVAEGEQESPLSVLSRTTLAEILKFVNEVQFAAIRFILDSAKLNCALSQEGLSGNWGLHIGATLEKQCERGLLAKDLSSSIVIRTSAASDARMGGATLPAMSNSGSGNQGITATMPVVVVAEHFGADDERLARALMLLHLSAIYIHNQLPRLSALCAATTAAMGAAAGMAWLVDGRYETISMAISSMIGDVSGMICDGASNSCAMKVSTSASAAWKAVLMALDDTAVTGNEGIVAHDVEQSIANLCALASHSMQQTDRQIIEIMASKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BY9</accession>
    <name>Q32BY9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000124305.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404657.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BY9"/>
    <dbReference type="STRING" id="300267.SDY_3153"/>
    <dbReference type="EnsemblBacteria" id="ABB63166">
        <property type="protein sequence ID" value="ABB63166"/>
        <property type="gene ID" value="SDY_3153"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3153"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3765"/>
    <dbReference type="HOGENOM" id="CLU_091606_0_0_6"/>
    <dbReference type="OMA" id="MVANHAP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="192" mass="20214" checksum="50DAC6658513EEF8" modified="2005-12-06" version="1">MARSHFSSQALVLIVISIAINMIGGQLASMVKLPIFLDSIGTLISAVLLGPVIGMLTGLLTNLLWELLTDPIAAAFAPVAMVIGLVAGWLARAGWFRTLPKVVVSGVIITLAVTVVAVPLRTALFGGVTGSGADLFVAWMHSMGQNLVESVAITVIGANLVDKTLTAVIVWLLLRQLPIRTTRHFPAMAAVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C11</accession>
    <name>METK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-adenosylmethionine synthase</fullName>
            <shortName evidence="1">AdoMet synthase</shortName>
            <ecNumber evidence="1">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metK</name>
        <name type="ordered locus">SDY_3130</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001062128.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404635.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C11"/>
    <dbReference type="SMR" id="Q32C11"/>
    <dbReference type="STRING" id="300267.SDY_3130"/>
    <dbReference type="EnsemblBacteria" id="ABB63144">
        <property type="protein sequence ID" value="ABB63144"/>
        <property type="gene ID" value="SDY_3130"/>
    </dbReference>
    <dbReference type="GeneID" id="66673177"/>
    <dbReference type="KEGG" id="sdy:SDY_3130"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3740"/>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_6"/>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000241036" description="S-adenosylmethionine synthase">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="230"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <sequence length="384" mass="41952" checksum="97FA8CF17B542941" modified="2005-12-06" version="1">MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C96</accession>
    <name>Q32C96_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prepilin peptidase dependent protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppdB</name>
        <name evidence="3" type="ordered locus">SDY_3042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001144294.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404550.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C96"/>
    <dbReference type="STRING" id="300267.SDY_3042"/>
    <dbReference type="EnsemblBacteria" id="ABB63059">
        <property type="protein sequence ID" value="ABB63059"/>
        <property type="gene ID" value="SDY_3042"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3042"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3647"/>
    <dbReference type="HOGENOM" id="CLU_090952_0_0_6"/>
    <dbReference type="OMA" id="RRAGYCQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016419">
        <property type="entry name" value="Prepilin_Pept-dep_B_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004525">
        <property type="entry name" value="Pilin_peptidase-dep_B_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="187" mass="20348" checksum="21DE57DADE132244" modified="2005-12-06" version="1">MPVKEQGFSLLEVLIAMAISSVLLLGAARFLPALQCESLTSTRKLALEDEIWLRVFTVAKHLQRAGYCHGSCTGEGLEIVGQGDCIIVQWDANSNGIWDREPVKESDQIGFRLKEHVLETLRGATSCEGKGWDKVTNPDAIIIDTFQVTRQDVSGFSPVLTVNMHAASKADPQTVVDASYSVTGSNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CB6</accession>
    <name>FUCI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-fucose isomerase</fullName>
            <ecNumber evidence="1">5.3.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">6-deoxy-L-galactose isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>FucIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fucI</name>
        <name type="ordered locus">SDY_3020</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts the aldose L-fucose into the corresponding ketose L-fuculose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fucose = L-fuculose</text>
            <dbReference type="Rhea" id="RHEA:17233"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:17617"/>
            <dbReference type="EC" id="5.3.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the L-fucose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000724185.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404530.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CB6"/>
    <dbReference type="SMR" id="Q32CB6"/>
    <dbReference type="STRING" id="300267.SDY_3020"/>
    <dbReference type="EnsemblBacteria" id="ABB63039">
        <property type="protein sequence ID" value="ABB63039"/>
        <property type="gene ID" value="SDY_3020"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3020"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3626"/>
    <dbReference type="HOGENOM" id="CLU_033326_1_0_6"/>
    <dbReference type="OMA" id="QDYRACA"/>
    <dbReference type="UniPathway" id="UPA00563">
        <property type="reaction ID" value="UER00624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042355">
        <property type="term" value="P:L-fucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.14.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01254">
        <property type="entry name" value="Fucose_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038393">
        <property type="entry name" value="Fuc_iso_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038391">
        <property type="entry name" value="Fucose_iso_dom1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012888">
        <property type="entry name" value="Fucose_iso_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005763">
        <property type="entry name" value="Fucose_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038392">
        <property type="entry name" value="Fucose_isomerase_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012889">
        <property type="entry name" value="Fucose_isomerase_N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07881">
        <property type="entry name" value="Fucose_iso_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07882">
        <property type="entry name" value="Fucose_iso_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01089">
        <property type="entry name" value="fucI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0294">Fucose metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000067225" description="L-fucose isomerase">
        <location>
            <begin position="1"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01254"/>
        </source>
    </evidence>
    <sequence length="591" mass="65126" checksum="0DB3EE03CEFCDDD3" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CH9</accession>
    <name>CYSN_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfate adenylyltransferase subunit 1</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP-sulfurylase large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Sulfate adenylate transferase</fullName>
            <shortName evidence="2">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cysN</name>
        <name type="ordered locus">SDY_2950</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of CysD, the smaller subunit, and CysN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001090340.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404467.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CH9"/>
    <dbReference type="SMR" id="Q32CH9"/>
    <dbReference type="STRING" id="300267.SDY_2950"/>
    <dbReference type="EnsemblBacteria" id="ABB62976">
        <property type="protein sequence ID" value="ABB62976"/>
        <property type="gene ID" value="SDY_2950"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2950"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3542"/>
    <dbReference type="HOGENOM" id="CLU_007265_5_2_6"/>
    <dbReference type="OMA" id="FPVQYVL"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00062">
        <property type="entry name" value="Sulf_adenylyltr_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000008910" description="Sulfate adenylyltransferase subunit 1">
        <location>
            <begin position="1"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="25"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="113"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00062"/>
        </source>
    </evidence>
    <sequence length="475" mass="52591" checksum="61EDDCBF9739A663" modified="2005-12-06" version="1">MNTALAQQIANEGGVEAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSLHNDSKRHGTQGEKLDLALLVDGLQAEREQGITIDVAYRYFSTEKRKFIIADTPGHEQYTRNMATGASTCELAILLIDARKGVLDQTRRHSFISTLLGIKHLVVAINKMDLMDYSEETFTRIREDYLTFAGQLPGNLDIRFVPLSALEGDNVASQSESMPWYSGPTLLEVLETVEIQRVVDAQPMRFPVQYVNRPNLDFRGYAGTLASGRVEVGQRVKVLPSGVESNVARIVTFDGDREEAFAGEAITLVLTDEIDISRGDLLLAADEALPAVQSASVDVVWMAEQPLSPGQSYDIKIAGKKTRARVDGIRYQVDINNLTQREVENLPLNGIGLVDLTFDEPLVLDRYQQNPVTGGLIFIDRLSNVTVGAGMVHEPVSQATAAPSEFSAFELELNALVRRHFPHWGARDLLGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CM7</accession>
    <name>Q32CM7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-bound lytic murein transglycosylase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mltB</name>
        <name evidence="4" type="ordered locus">SDY_2897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000476837.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404419.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CM7"/>
    <dbReference type="STRING" id="300267.SDY_2897"/>
    <dbReference type="CAZy" id="GH103">
        <property type="family name" value="Glycoside Hydrolase Family 103"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62928">
        <property type="protein sequence ID" value="ABB62928"/>
        <property type="gene ID" value="SDY_2897"/>
    </dbReference>
    <dbReference type="GeneID" id="58460134"/>
    <dbReference type="KEGG" id="sdy:SDY_2897"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3480"/>
    <dbReference type="HOGENOM" id="CLU_035402_1_0_6"/>
    <dbReference type="OMA" id="GHTNLWD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011757">
        <property type="entry name" value="Lytic_transglycosylase_MltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163:SF0">
        <property type="entry name" value="PTHR30163:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02282">
        <property type="entry name" value="MltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220647" evidence="2">
        <location>
            <begin position="24"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_2" evidence="3">
        <location>
            <begin position="57"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="361" mass="40298" checksum="116BBD8EB98D50E8" modified="2005-12-06" version="1">MFKRRYVTLLPLFVLLAACSSKPKPTETETTTGTPSGGFLLEPQHNVMQMGGDFANNPNAQQFIDKMVNKHGFDRQQLQEILSQAKRLDSVLRLMDNQAPTTSVKPPSGPNGAWLRYRKKFITPDNVQNGVVFWNQYEDALNRAWQVYGVPPEIIVGIIGVETRWGRVMGKTRILDALATLSFNYPRRAEYFSGELETFLLMARDEQDDPLNLKGSFAGAMGYGQFMPSSYKQYAVDFSGDGHINLWDPVDAIGSVANYFKAHGWVKGDQVAVMANGQAPGLPNGFKTRYSISQLAAAGLTPQQPLGNHQQASLLRLDVGTGYQYWYGLPNFYTITRYNHSTHYAMAVWQLGQAVALARVQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CV2</accession>
    <name>LEPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 4</fullName>
            <shortName evidence="1">EF-4</shortName>
            <ecNumber evidence="1">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lepA</name>
        <name type="ordered locus">SDY_2810</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000790175.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404344.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CV2"/>
    <dbReference type="SMR" id="Q32CV2"/>
    <dbReference type="STRING" id="300267.SDY_2810"/>
    <dbReference type="EnsemblBacteria" id="ABB62853">
        <property type="protein sequence ID" value="ABB62853"/>
        <property type="gene ID" value="SDY_2810"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2810"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3385"/>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_6"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000224795" description="Elongation factor 4">
        <location>
            <begin position="1"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <sequence length="599" mass="66598" checksum="50286A16422F68CF" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CZ3</accession>
    <name>Q32CZ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS4 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CZ3"/>
    <dbReference type="STRING" id="300267.SDY_2769"/>
    <dbReference type="EnsemblBacteria" id="ABB62812">
        <property type="protein sequence ID" value="ABB62812"/>
        <property type="gene ID" value="SDY_2769"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2769"/>
    <dbReference type="HOGENOM" id="CLU_028400_1_1_6"/>
    <dbReference type="OMA" id="LYHRRWG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024473">
        <property type="entry name" value="Transposases_IS4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13006">
        <property type="entry name" value="Nterm_IS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nterm_IS4" evidence="2">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="400" mass="45794" checksum="46CBBADE8D088D42" modified="2005-12-06" version="1">MFPDFFMHIGQALDLVSRYDSLRNPLTSLGDYLAPELISRCLAESGTVTLRKRRLPLEMMVWCIVGMVLERKEPLHQIVNRLDIMLPGNRPFVAPSAVIQARQRLGSEAVRRVFTKTAQLWHNATPHPHWCGLTLLAIDGVFWRTPDTPENDAAFPRQTHAGNPALYPQVKMVCQMELTSHLLTAAAFGTMKNSENELAEQLIEQTGDNTLTLMDKGYYSLGLLNAWSLAGEHRHWMIPLRKGAQYEEIRKLGKGDHLVKLKTSPQARKKWPGLGNEVTARLLTVTRKGKVCHLLTSMTDAMRFPGGEMADLYSHRWEIELGYREIKQTMQLSRLTLRSKKPELVEQELWGVLLAYNLVRYQMIKMAEHLKGYWPNQLSFSESCGMVMRCRALHRDVYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CZ9</accession>
    <name>Q32CZ9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_1181</name>
        <name evidence="9" type="ordered locus">SDY_2763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402828.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404297.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_1181"/>
    <dbReference type="EnsemblBacteria" id="ABB61337">
        <property type="protein sequence ID" value="ABB61337"/>
        <property type="gene ID" value="SDY_1181"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62806">
        <property type="protein sequence ID" value="ABB62806"/>
        <property type="gene ID" value="SDY_2763"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1181"/>
    <dbReference type="KEGG" id="sdy:SDY_2763"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1395"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="9897" checksum="088438896E13BDDC" modified="2005-12-06" version="1">MASVSISCPSCSATNGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVSLNTILRHLKNSGRSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D46</accession>
    <name>RODZ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytoskeleton protein RodZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rodZ</name>
        <name type="ordered locus">SDY_2712</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Forms helical filaments along the long axis of the cell.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The helix-turn-helix (HTH) motif in the cytoplasmic domain of the N-terminus is involved in the formation of spirals to maintain the rigid rod shape. As this protein is anchored in the cytoplasmic membrane, the HTH motif may contribute to protein-protein interactions to form the RodZ helix, which is localized beneath the cytoplasmic membrane. The C-terminal domain may be critical for determination of the rod shape by probably interacting with enzymes required for synthesis of the peptidoglycan layer, including PBPs in the periplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RodZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001090858.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404250.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D46"/>
    <dbReference type="SMR" id="Q32D46"/>
    <dbReference type="STRING" id="300267.SDY_2712"/>
    <dbReference type="EnsemblBacteria" id="ABB62759">
        <property type="protein sequence ID" value="ABB62759"/>
        <property type="gene ID" value="SDY_2712"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2712"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3270"/>
    <dbReference type="HOGENOM" id="CLU_047530_3_1_6"/>
    <dbReference type="OMA" id="ADCWTQV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RodZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025194">
        <property type="entry name" value="DUF4115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023690">
        <property type="entry name" value="RodZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13464">
        <property type="entry name" value="DUF4115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000361864" description="Cytoskeleton protein RodZ">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="133"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="337" mass="36201" checksum="190BD4E3BFF241C0" modified="2005-12-06" version="1">MNTEATHDQNEALTTGARLRNAREQLGLSQQAVAERLCLKVSTVRDIEEDKAPADLASTFLRGYIRSYARLVHIPEEELLPGLEKQAPLRAAKVAPMQSFSLGKRRKKRDGWLMTFTWLVLFVVIGLSGAWWWQDHKAQQEEITTMADQSSAELSSNSEQGQSVPLNTSTTTDPATTSTPPASVDTTATNTQTPAVTAPAPAVDPQQNAVVSPSQANVDTAATPVPTAATTPDGAAPLPTDQAGVTTPVADPNALVMNFTADCWLEVTDATGKKLFSGMQRKDGNLNLTGQAPYKLKIGAPAAVQIQYQGKPVDLSRFIRTNQVARLTLNAEQSPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D56</accession>
    <name>Q32D56_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000755178.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404240.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D56"/>
    <dbReference type="STRING" id="300267.SDY_2702"/>
    <dbReference type="EnsemblBacteria" id="ABB62749">
        <property type="protein sequence ID" value="ABB62749"/>
        <property type="gene ID" value="SDY_2702"/>
    </dbReference>
    <dbReference type="GeneID" id="58460742"/>
    <dbReference type="KEGG" id="sdy:SDY_2702"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3260"/>
    <dbReference type="HOGENOM" id="CLU_128672_0_0_6"/>
    <dbReference type="OMA" id="QMELENM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020231">
        <property type="entry name" value="Uncharacterised_YfgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17358">
        <property type="entry name" value="DUF5384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220905" evidence="2">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="179" mass="20244" checksum="ACB18E35D2C9BE86" modified="2005-12-06" version="1">MKKVFLCAILASLSYPAIASSLQDQLSAVAEAEQQGKNEEQRQHDEWVAERNREIQQEKQRRANAQAAANKRAATAAANKKARQDKLDAEATADKKRDQSYEDELRSLEIQKQKLALAKEEARVKRENEFIDQELKHKAAQTDVVQSEADANRNMTEGGRDLMKSVGKAEENKSDSWFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D71</accession>
    <name>Q32D71_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uraA</name>
        <name evidence="8" type="ordered locus">SDY_2686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000198331.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404225.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D71"/>
    <dbReference type="STRING" id="300267.SDY_2686"/>
    <dbReference type="EnsemblBacteria" id="ABB62734">
        <property type="protein sequence ID" value="ABB62734"/>
        <property type="gene ID" value="SDY_2686"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2686"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3240"/>
    <dbReference type="HOGENOM" id="CLU_017959_1_2_6"/>
    <dbReference type="OMA" id="INHGIGM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="429" mass="45090" checksum="18044490C6CA7674" modified="2005-12-06" version="1">MTRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVLFPPAAMGAIVAVIGLELAGVAAGMAGLLPAEGQTPDSKTIIISITTLAVTVLGSVLFRGFLAIIPILIGVLVGYALSFAMGIVDTTPIINAHWFALPTLYTPRFEWFAILTILPAALVVIAEHVGHLVVTANIVKKDLLRDPGLHRSMFANGLSTVISGFFGSTPNTTYGENIGVMAITRVYSTWVIGGAAIFTILLSCVGKLAAAIQMIPLPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVNIGAAELKGMALATIVGIGLSLIFKLISVLRPEEVVLDAEDADITDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D76</accession>
    <name>Q32D76_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable formate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">focB</name>
        <name evidence="7" type="ordered locus">SDY_2681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FNT transporter (TC 2.A.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001244719.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404220.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D76"/>
    <dbReference type="STRING" id="300267.SDY_2681"/>
    <dbReference type="EnsemblBacteria" id="ABB62729">
        <property type="protein sequence ID" value="ABB62729"/>
        <property type="gene ID" value="SDY_2681"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2681"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3235"/>
    <dbReference type="HOGENOM" id="CLU_036896_3_0_6"/>
    <dbReference type="OMA" id="WMAYGAK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00790">
        <property type="entry name" value="fnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="282" mass="30594" checksum="B96437EA29A51A37" modified="2005-12-06" version="1">MRNKLSFDLQLSARKAAIAERIAAHKIARSKVSVFLMAMSAGVFMAIGFTFYLSVIADAPSSQALTHLVGGLCFTLGFILLAVCGTNLFTSSVMTVMAKSRGVISWRTWLINALLVACGNLAGIACFSLLIWFSGLVMSENAMWGVAVLHCAEGKMHHTFTESVSLGIMCNLMVCLALWMSYCGRSLCDKIVAMILPITLFVASGFEHCIANLFVIPFAIAIRHFAPTPFWQLAHSSADNFPALTVSHFITANLLPVMLGNIIGGAVLVSICYRAIYLRQEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DF7</accession>
    <name>GLK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glk</name>
        <name type="ordered locus">SDY_2587</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial glucokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000170345.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404139.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DF7"/>
    <dbReference type="SMR" id="Q32DF7"/>
    <dbReference type="STRING" id="300267.SDY_2587"/>
    <dbReference type="EnsemblBacteria" id="ABB62648">
        <property type="protein sequence ID" value="ABB62648"/>
        <property type="gene ID" value="SDY_2587"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2587"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3121"/>
    <dbReference type="HOGENOM" id="CLU_042582_1_0_6"/>
    <dbReference type="OMA" id="NNHWRLS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00524">
        <property type="entry name" value="Glucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003836">
        <property type="entry name" value="Glucokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02685">
        <property type="entry name" value="Glucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00749">
        <property type="entry name" value="glk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000268788" description="Glucokinase">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00524"/>
        </source>
    </evidence>
    <sequence length="321" mass="34697" checksum="2D70B526641A3823" modified="2005-12-06" version="1">MTKYALVGDVGGTNARLALCDIASGEISQAKTYSGLDYPSLEAVIRVYLEEHKVEVKDGCIAIACPITGDWVAMTNHTWAFSIAEMKKNLGFSHLEIINDFTAVSMAIPMLKKEHLIQFGGAEPVEGKPIAVYGAGTGLGVAHLVHVDKRWVSLPGEGGHVDFAPNSEEEAIILEILRAEIGHVSAERVLSGPGLVNLYRAIVKADNRLPENLKPKDITERALADSCTDCRRALSLFCVIMGRFGGNLALNLGTFGGVFIAGGIVPRFLEFFKASGFRAAFEDKGRFKEYVHDIPVYLIVHDNAGLLGSGAHLRQTLGHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DH7</accession>
    <name>Q32DH7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein Y</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">emrY</name>
        <name evidence="8" type="ordered locus">SDY_2562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001018704.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404119.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DH7"/>
    <dbReference type="STRING" id="300267.SDY_2562"/>
    <dbReference type="EnsemblBacteria" id="ABB62628">
        <property type="protein sequence ID" value="ABB62628"/>
        <property type="gene ID" value="SDY_2562"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2562"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3086"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_6"/>
    <dbReference type="OMA" id="NLPVMAV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="19"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="512" mass="56015" checksum="A89FEB2DBF50FD94" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DI6</accession>
    <name>Q32DI6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vacJ</name>
        <name evidence="5" type="ordered locus">SDY_2550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MlaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000776768.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404110.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DI6"/>
    <dbReference type="SMR" id="Q32DI6"/>
    <dbReference type="STRING" id="300267.SDY_2550"/>
    <dbReference type="EnsemblBacteria" id="ABB62619">
        <property type="protein sequence ID" value="ABB62619"/>
        <property type="gene ID" value="SDY_2550"/>
    </dbReference>
    <dbReference type="GeneID" id="66673772"/>
    <dbReference type="KEGG" id="sdy:SDY_2550"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3069"/>
    <dbReference type="HOGENOM" id="CLU_059326_3_2_6"/>
    <dbReference type="OMA" id="PYRYIDH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007428">
        <property type="entry name" value="MlaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30035">
        <property type="entry name" value="PTHR30035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04333">
        <property type="entry name" value="MlaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01805">
        <property type="entry name" value="VACJLIPOPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220790" evidence="4">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="251" mass="28008" checksum="AA08C022C6E115B9" modified="2005-12-06" version="1">MKLRLSALALGTTLLVGCASSGTDQQGRSDPLEGFNRTMYNFNFNVLDPYIVRPVAVAWRDYVPQPARNGLSNFTGNLEEPAVMVNYFLQGDPYQGMVHFTRFFLNTILGMGGFIDVAGMANPKLQRTEPHRFGSTLGHYGVGYGPYVQLPFYGSFTLRDDGGDMADGLYPVLSWLTWPMSVGKWTLEGIETRAQLLDSDGLLRQSSDPYIMVREAYFQRHDFIANGGELKPQENPNAQAIQDDLKDIDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DL4</accession>
    <name>Q32DL4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_2521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404082.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DL4"/>
    <dbReference type="STRING" id="300267.SDY_2521"/>
    <dbReference type="EnsemblBacteria" id="ABB62591">
        <property type="protein sequence ID" value="ABB62591"/>
        <property type="gene ID" value="SDY_2521"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2521"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3036"/>
    <dbReference type="HOGENOM" id="CLU_1803216_0_0_6"/>
    <dbReference type="OMA" id="IMNWAMA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="150" mass="15448" checksum="7AABFF1847DE13E1" modified="2005-12-06" version="1">MFIMNWAMAGFTLTAFGGAFVVMRVMFGWVPDRFGGVKVAIVSLLVETVGLLLLWQAPGAWVALAGAALTGAGCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDIAFGVSGPLAGMLATTFGYSSVFLAGAISAVLGIIVTILSFRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DN4</accession>
    <name>Q32DN4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sugar nucleotide epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_2501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001028311.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404062.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DN4"/>
    <dbReference type="STRING" id="300267.SDY_2501"/>
    <dbReference type="EnsemblBacteria" id="ABB62571">
        <property type="protein sequence ID" value="ABB62571"/>
        <property type="gene ID" value="SDY_2501"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2501"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3013"/>
    <dbReference type="HOGENOM" id="CLU_047373_0_3_6"/>
    <dbReference type="OMA" id="YMPWIHI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="249"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="297" mass="32701" checksum="11DDA7C50EE60148" modified="2005-12-06" version="1">MNIVITGGTGLIGRHLIPRLLDLSHKITVVTRNPQKASSVLGPQVTLWQGLADQSNLNGVDAVINLAGEPIADKRWTHEQKERLCQSRWNITQKLVDLINASDTPPSVLISGSATGYYGDLGEVVVTEEEPPHNEFTHKLCARWEEIACRAQSDKTRVCLLRTGVVLAPDGGILGKMLPPFRLGLGGPIGSGRQYLAWIHIDDMVNGILWLLDNELRGPFNMVSPYPIRNEQFAHALGHALHRPAILRVPATAIRLLMGESSVLVLGGQRALPKRLEEAGFAFRWYDLEEALADVVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DS7</accession>
    <name>MENC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">o-succinylbenzoate synthase</fullName>
            <shortName evidence="1">OSB synthase</shortName>
            <shortName evidence="1">OSBS</shortName>
            <ecNumber evidence="1">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">menC</name>
        <name type="ordered locus">SDY_2457</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001255628.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404019.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DS7"/>
    <dbReference type="SMR" id="Q32DS7"/>
    <dbReference type="STRING" id="300267.SDY_2457"/>
    <dbReference type="EnsemblBacteria" id="ABB62528">
        <property type="protein sequence ID" value="ABB62528"/>
        <property type="gene ID" value="SDY_2457"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2457"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2964"/>
    <dbReference type="HOGENOM" id="CLU_030273_0_1_6"/>
    <dbReference type="OMA" id="YEANRDG"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00470">
        <property type="entry name" value="MenC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010196">
        <property type="entry name" value="OSB_synthase_MenC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000013812" description="o-succinylbenzoate synthase">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00470"/>
        </source>
    </evidence>
    <sequence length="320" mass="35477" checksum="E20245EC13D06839" modified="2005-12-06" version="1">MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLREGEREGWGEISPLPGFSQETWEEAQSVLLAWVNNWLAGDCELPQMPSVAFGVSCALAELTDTLPQAANYRAAPLCNGDPDDLILKLADMPGEKVAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKGQQFAKYVNPDYRDRIAFLEEPCKTRDDSRAFARETGIAIAWDESLREPDFAFVAEEGVRAVVIKPTLTGSLEKVREQVQAAHALGLTAVISSSIESSLGLTQLARIAAWLTPDTIPGLDTLDLMQAQQVRRWPGSTLPVVEVDALERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E33</accession>
    <name>Q32E33_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ycaI</name>
        <name evidence="8" type="ordered locus">SDY_2345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E33"/>
    <dbReference type="STRING" id="300267.SDY_2345"/>
    <dbReference type="EnsemblBacteria" id="ABB62422">
        <property type="protein sequence ID" value="ABB62422"/>
        <property type="gene ID" value="SDY_2345"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2345"/>
    <dbReference type="HOGENOM" id="CLU_010363_3_0_6"/>
    <dbReference type="OMA" id="RTDKQGA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
        <property type="term" value="P:establishment of competence for transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004797">
        <property type="entry name" value="Competence_ComEC/Rec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00361">
        <property type="entry name" value="ComEC_Rec2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="534"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="780" mass="87413" checksum="11BA2415258C3C88" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E39</accession>
    <name>Q32E39_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000436931.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403907.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E39"/>
    <dbReference type="STRING" id="300267.SDY_2339"/>
    <dbReference type="EnsemblBacteria" id="ABB62416">
        <property type="protein sequence ID" value="ABB62416"/>
        <property type="gene ID" value="SDY_2339"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2339"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2823"/>
    <dbReference type="HOGENOM" id="CLU_080412_0_0_6"/>
    <dbReference type="OMA" id="WYQQRVE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="64"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="297" mass="34516" checksum="90C62C0E67B07621" modified="2005-12-06" version="1">MEQLRAELSHLLGEKLSRIECVNEKADTALWALYDSQGNPMPLMARSFSTPGRARQLAWKTTMLARSGTVRMPTIYGVMTHEEHPGPDVLLLERMRGVSVEAPARTPERWEQLKDQIVEALLAWHRQDSRGCVGAVDNTQENFWPSWYRQHVEVLWTTLNQFNNTGLTMQDKRILFRTRECLPALFEGFNDNCVLIHGNFCLRSMLKDSRSDQLLAMVGPGLMLWAPREYELFRLMDNSLAEDLLWSYLQRAPVAESFIWRRWLYVLWDEVAQLVNTGRFSRRNFDLASKSLLPWLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E75</accession>
    <name>OPGC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucans biosynthesis protein C</fullName>
            <ecNumber evidence="1">2.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mdoC</name>
        <name evidence="1" type="synonym">opgC</name>
        <name type="ordered locus">SDY_2303</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; osmoregulated periplasmic glucan (OPG) biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyltransferase 3 family. OpgC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001070377.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403871.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E75"/>
    <dbReference type="STRING" id="300267.SDY_2303"/>
    <dbReference type="EnsemblBacteria" id="ABB62380">
        <property type="protein sequence ID" value="ABB62380"/>
        <property type="gene ID" value="SDY_2303"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2303"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2780"/>
    <dbReference type="HOGENOM" id="CLU_036182_2_0_6"/>
    <dbReference type="OMA" id="YFSYMLY"/>
    <dbReference type="UniPathway" id="UPA00637"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016741">
        <property type="term" value="F:transferase activity, transferring one-carbon groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01066">
        <property type="entry name" value="MdoC_OpgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023723">
        <property type="entry name" value="Glucans_biosynth_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000064516" description="Glucans biosynthesis protein C">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01066"/>
        </source>
    </evidence>
    <sequence length="385" mass="44760" checksum="9EF55F93D48DD6A3" modified="2005-12-06" version="1">MNPVPAQREYFLDSIRAWLMLLGIPFHISLIYSSHTWHVNSTEPSLWLTLFNDFIHSFRMQVFFVISGYFSYMLFLRYPLKKWWKVRVERVGIPMLTAIPLLTLPQFIMLQYVKGKTKSWPGLSLYDKYNTLAWELISHLWFLLVLVVMTTLCVWIFKRIRNNLENSDKTNKKFSMVKLSVIFLCLGIGYAVIRRTIFIVYPPILSNGMFNFIVMQTLFYLPFFILGALAFIFPHLKALFTTPSRGCTLAAALAFVAYLLNQRYGSGDAWMYETESVITMVLGLWMVNVVFSFGHRLLNFQSARVTYFVNASLFIYLVHHPLTLFFGAYITPHITSNWLGFLCGLIFVVGIAIILYEIHLRIPLLKFLFSGKPVVKRENDKAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E77</accession>
    <name>Q32E77_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Glucans biosynthesis glucosyltransferase H</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">mdoH</name>
        <name evidence="8" type="synonym">opgH</name>
        <name evidence="10" type="ordered locus">SDY_2301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Glycan metabolism; osmoregulated periplasmic glucan (OPG) biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell inner membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the glycosyltransferase 2 family. OpgH subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378796.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403869.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E77"/>
    <dbReference type="STRING" id="300267.SDY_2301"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62378">
        <property type="protein sequence ID" value="ABB62378"/>
        <property type="gene ID" value="SDY_2301"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2301"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2777"/>
    <dbReference type="HOGENOM" id="CLU_015730_1_0_6"/>
    <dbReference type="OMA" id="TAGLHYW"/>
    <dbReference type="UniPathway" id="UPA00637"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01072">
        <property type="entry name" value="MdoH_OpgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023725">
        <property type="entry name" value="Glucans_biosynth_gluTrFase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="682"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="9">
        <location>
            <begin position="246"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="847" mass="96981" checksum="3DD7565CA18B962E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EK3</accession>
    <name>Q32EK3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yehR</name>
        <name evidence="2" type="ordered locus">SDY_2166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403743.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EK3"/>
    <dbReference type="STRING" id="300267.SDY_2166"/>
    <dbReference type="EnsemblBacteria" id="ABB62252">
        <property type="protein sequence ID" value="ABB62252"/>
        <property type="gene ID" value="SDY_2166"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2166"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2618"/>
    <dbReference type="HOGENOM" id="CLU_126600_1_0_6"/>
    <dbReference type="OMA" id="TEISIAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009736">
        <property type="entry name" value="DUF1307"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036699">
        <property type="entry name" value="YehR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06998">
        <property type="entry name" value="DUF1307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006187">
        <property type="entry name" value="DUF1307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160704">
        <property type="entry name" value="SSF160704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220681" evidence="1">
        <location>
            <begin position="26"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="157" mass="17146" checksum="9AB6BFA98A13367D" modified="2005-12-06" version="1">MEFYMKAFNKLISLVVASVLVFSLAGCGDKEESKKFSANLNGTEIAITYVYKGDKVLKQSSETKIQFASIGATTKEDAAKTLEPLSAKYKNIAGVEEKLTYTDTYAQENVTIDMEKVDFKAQQGISGINVSAEDAKKGITMAQMELVMKAAGFKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ES2</accession>
    <name>Q32ES2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Damage-inducible protein I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dinI</name>
        <name evidence="1" type="ordered locus">SDY_2092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001258621.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403674.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ES2"/>
    <dbReference type="STRING" id="300267.SDY_2092"/>
    <dbReference type="EnsemblBacteria" id="ABB62183">
        <property type="protein sequence ID" value="ABB62183"/>
        <property type="gene ID" value="SDY_2092"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2092"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2517"/>
    <dbReference type="HOGENOM" id="CLU_139795_1_0_6"/>
    <dbReference type="OMA" id="TPWCHSS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036687">
        <property type="entry name" value="DinI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010391">
        <property type="entry name" value="DNA_damage-inducible_DinI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36572">
        <property type="entry name" value="PTHR36572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06183">
        <property type="entry name" value="DinI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54857">
        <property type="entry name" value="SSF54857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="81" mass="8918" checksum="1788C919440D828D" modified="2005-12-06" version="1">MRTEVTIAKTSPLPAGAIDALAGELSRHIQYAFPDNEGHVSVRYAAANNLSVIGATKEDKQRISEILQETWESADDWFVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FD0</accession>
    <name>Q32FD0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000670990.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403466.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FD0"/>
    <dbReference type="STRING" id="300267.SDY_1866"/>
    <dbReference type="EnsemblBacteria" id="ABB61975">
        <property type="protein sequence ID" value="ABB61975"/>
        <property type="gene ID" value="SDY_1866"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1866"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2245"/>
    <dbReference type="HOGENOM" id="CLU_178515_0_0_6"/>
    <dbReference type="OMA" id="YSGEIWH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012451">
        <property type="entry name" value="DUF1656"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07869">
        <property type="entry name" value="DUF1656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="78" mass="8863" checksum="AFD3C8DEEBD53F75" modified="2005-12-06" version="1">MKFMLNATGLPLQDLVFGASVYFPPFFKAFAFGFVIWLVAHRLLRGWIYAGDIWHPLLMDLSLFAICVCLALAILIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FW3</accession>
    <name>Q32FW3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FW3"/>
    <dbReference type="STRING" id="300267.SDY_1671"/>
    <dbReference type="EnsemblBacteria" id="ABB61792">
        <property type="protein sequence ID" value="ABB61792"/>
        <property type="gene ID" value="SDY_1671"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1671"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="TPMESFW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27585" checksum="802DDEBF56218064" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVPDLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNTPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FX4</accession>
    <name>Q32FX4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ARAC-type regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000060463.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403272.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FX4"/>
    <dbReference type="STRING" id="300267.SDY_1660"/>
    <dbReference type="EnsemblBacteria" id="ABB61781">
        <property type="protein sequence ID" value="ABB61781"/>
        <property type="gene ID" value="SDY_1660"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1660"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2000"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_4_6"/>
    <dbReference type="OMA" id="HMGMNTG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="137"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="259" mass="29504" checksum="ABD159F549F93D0C" modified="2005-12-06" version="1">MSLVCSVIFIHHAFNANILDKDYAFSDGEILMVDNAVRTHFEPYERHFKEIGFNENTIKKYLQCTNIQTVTMPVPAKFLRASNVPTGLLNEMIAYLNSEERNHHNFSELLLFSCLSIFAACKGFITLLTNGVLSVSGKVRNIVNMKLAHPWKLKDICDCLYISESLLKKKLKQEQTTFSQILLDARMQHAKNLIRVEGSVNKIAEQCGYASTSYFIYAFRKHFGNSPKRVSKEYRCQSHMGMNTGNTMNALAILLFANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G16</accession>
    <name>Q32G16_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate/gamma-aminobutyrate antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">xasA</name>
        <name evidence="11" type="ordered locus">SDY_1614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-aminobutanoate(in) + L-glutamate(out) = 4-aminobutanoate(out) + L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:28919"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Glutamate:GABA antiporter (GGA) (TC 2.A.3.7) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378687.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403230.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G16"/>
    <dbReference type="STRING" id="300267.SDY_1614"/>
    <dbReference type="EnsemblBacteria" id="ABB61739">
        <property type="protein sequence ID" value="ABB61739"/>
        <property type="gene ID" value="SDY_1614"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1614"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1942"/>
    <dbReference type="HOGENOM" id="CLU_020854_4_0_6"/>
    <dbReference type="OMA" id="RIEPSRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004759">
        <property type="entry name" value="Glu_antiport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00910">
        <property type="entry name" value="2A0307_GadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB61739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="511" mass="55115" checksum="29FC1C1589316A10" modified="2005-12-06" version="1">MATSVQTGKAKQLTLLGFFAITASMVMAVYDYPTFATSGFSLVFFLLLGGILWFIPVGLCAAEMATVDGWEEGGVFAWVSNTLGPRWGFAAISFGYLQIAIGFIPMLYFVLGALSYILKWPALNEEPITKTIAALIILWALALTQFGGTKYTARIAKVGFFAGILLPAFILIALAAIYLHSGAPVAIEMDSKTFFPDFSKVGTLVVFVAFILSYMGVEASATHVNEMSNPGRDYPLAMLLLMVAAICLSSVGGLSIAMVISGNEINLSAGVMQTFTVLMSHVAPEIEWTVRVISALLLLGVLAEIASWIVGPSRGMYVTAQKNLLPTAFAKMNKNGVPVTLVISQLVITSIALIILTNTGGGNNMSFLIALALTVVIYLCAYFMLFIGYIVLVLKHPDLKRTFNIPGGKGVKLVVAIVGLLTSIMAFIVSFLPPDNIQGDSTDMYVELLVVSFMVVLALPFILYAVHDRKGKANTGVTLEPINSKNAPKGHFFLHPRARSPHYIVMNDKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GG0</accession>
    <name>Q32GG0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron transport protein, inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sitD</name>
        <name evidence="8" type="ordered locus">SDY_1454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000968135.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403086.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GG0"/>
    <dbReference type="STRING" id="300267.SDY_1454"/>
    <dbReference type="EnsemblBacteria" id="ABB61595">
        <property type="protein sequence ID" value="ABB61595"/>
        <property type="gene ID" value="SDY_1454"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1454"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1732"/>
    <dbReference type="HOGENOM" id="CLU_028808_4_0_6"/>
    <dbReference type="OMA" id="CALLSCW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="285" mass="30590" checksum="CF0AF78766CCC52F" modified="2005-12-06" version="1">MMALLLEPLQFTFMSHALLISLVVSIPCALLSVFLVLKGWALMGDAMSHAVFPGIVLTWILGLPLATGAFVAGVFCAVATGYLKDNSRIKQDTVMGIVFSGMFAAGLILYIAIKPDVHLDHILFGDMLGITIGDIIQTVIIAGLVTLVISVKWRDFLLFSFDYQQAQVSGLHTRWLHYGLLCMVSLTIVATLKAVGIILSISLLIAPGAIAVLLTQRFHITLLLATGISVIVSMTGVCLSFFIDSAPAPTIVVLFAVVFIMTFTVTSINARTKGNAHTQDLLSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GS7</accession>
    <name>Q32GS7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">trpD</name>
        <name evidence="9" type="ordered locus">SDY_1331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000763549.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402969.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GS7"/>
    <dbReference type="STRING" id="300267.SDY_1331"/>
    <dbReference type="MEROPS" id="C26.960"/>
    <dbReference type="EnsemblBacteria" id="ABB61478">
        <property type="protein sequence ID" value="ABB61478"/>
        <property type="gene ID" value="SDY_1331"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1331"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1581"/>
    <dbReference type="HOGENOM" id="CLU_014340_4_0_6"/>
    <dbReference type="OMA" id="VIYRNHV"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="GATase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_trans_3N" evidence="8">
        <location>
            <begin position="202"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="7">
        <location>
            <begin position="273"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="5">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="5">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="5">
        <location>
            <begin position="306"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="531" mass="56861" checksum="9020BDA1D21F30BD" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GU0</accession>
    <name>YCIB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inner membrane-spanning protein YciB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yciB</name>
        <name type="ordered locus">SDY_1318</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000808678.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402956.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GU0"/>
    <dbReference type="STRING" id="300267.SDY_1318"/>
    <dbReference type="EnsemblBacteria" id="ABB61465">
        <property type="protein sequence ID" value="ABB61465"/>
        <property type="gene ID" value="SDY_1318"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1318"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1565"/>
    <dbReference type="HOGENOM" id="CLU_089554_2_0_6"/>
    <dbReference type="OMA" id="AWVNFKL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00189">
        <property type="entry name" value="YciB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006008">
        <property type="entry name" value="YciB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36917">
        <property type="entry name" value="PTHR36917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04279">
        <property type="entry name" value="IspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00997">
        <property type="entry name" value="ispZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000021065" description="Inner membrane-spanning protein YciB">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00189"/>
        </source>
    </evidence>
    <sequence length="179" mass="20820" checksum="08C538F88F997ABE" modified="2005-12-06" version="1">MKQFLDFLPLVVFFAFYKIYDIYAATTALIVATAIVLIYSWVRFRKVEKMALITFVLVVVFGGLTLFFHNDEFIKWKVTVIYALFAGALLVSQWVMKKPLIQRMLGKELTLPQPVWSKLNLAWAVFFILCGLANIYIAFWLPQNIWVNFKVFGLTALTLIFTLLSGIYIYRHMPQEDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GW3</accession>
    <name>Q32GW3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde-alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adhE</name>
        <name evidence="5" type="ordered locus">SDY_1295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000301651.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402933.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GW3"/>
    <dbReference type="SMR" id="Q32GW3"/>
    <dbReference type="STRING" id="300267.SDY_1295"/>
    <dbReference type="EnsemblBacteria" id="ABB61442">
        <property type="protein sequence ID" value="ABB61442"/>
        <property type="gene ID" value="SDY_1295"/>
    </dbReference>
    <dbReference type="GeneID" id="66674939"/>
    <dbReference type="KEGG" id="sdy:SDY_1295"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1537"/>
    <dbReference type="HOGENOM" id="CLU_007207_2_2_6"/>
    <dbReference type="OMA" id="QWFKVPP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012079">
        <property type="entry name" value="Bifunc_Ald-ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000111">
        <property type="entry name" value="ALDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="5"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-ADH" evidence="4">
        <location>
            <begin position="457"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="891" mass="96127" checksum="75469F57419C8C79" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GW4</accession>
    <name>Q32GW4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_1268</name>
        <name evidence="4" type="ordered locus">SDY_1294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61417">
        <property type="protein sequence ID" value="ABB61417"/>
        <property type="gene ID" value="SDY_1268"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61441">
        <property type="protein sequence ID" value="ABB61441"/>
        <property type="gene ID" value="SDY_1294"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1268"/>
    <dbReference type="KEGG" id="sdy:SDY_1294"/>
    <dbReference type="HOGENOM" id="CLU_076276_5_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="64" mass="7633" checksum="956BA7CF38655E65" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWLLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H09</accession>
    <name>TREA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Periplasmic trehalase</fullName>
            <ecNumber evidence="1">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha,alpha-trehalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Alpha,alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">treA</name>
        <name type="ordered locus">SDY_1246</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000841751.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402887.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H09"/>
    <dbReference type="SMR" id="Q32H09"/>
    <dbReference type="STRING" id="300267.SDY_1246"/>
    <dbReference type="CAZy" id="GH37">
        <property type="family name" value="Glycoside Hydrolase Family 37"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61397">
        <property type="protein sequence ID" value="ABB61397"/>
        <property type="gene ID" value="SDY_1246"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1246"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1478"/>
    <dbReference type="HOGENOM" id="CLU_006451_3_1_6"/>
    <dbReference type="OMA" id="TNGVLIW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01060">
        <property type="entry name" value="Peripl_trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023720">
        <property type="entry name" value="Trehalase_periplasmic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="PTHR23403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_1000064457" description="Periplasmic trehalase">
        <location>
            <begin position="31"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="277"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="565" mass="63666" checksum="A01107D805E0DD26" modified="2005-12-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H28</accession>
    <name>Q32H28_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycgB</name>
        <name evidence="1" type="ordered locus">SDY_1225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000190868.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402868.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H28"/>
    <dbReference type="STRING" id="300267.SDY_1225"/>
    <dbReference type="EnsemblBacteria" id="ABB61377">
        <property type="protein sequence ID" value="ABB61377"/>
        <property type="gene ID" value="SDY_1225"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1225"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1453"/>
    <dbReference type="HOGENOM" id="CLU_010179_3_0_6"/>
    <dbReference type="OMA" id="NSNPCYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007390">
        <property type="entry name" value="Spore_V_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30029">
        <property type="entry name" value="PTHR30029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04293">
        <property type="entry name" value="SpoVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="510" mass="60742" checksum="97DA86DFC7344ACB" modified="2005-12-06" version="1">MATIDSMNKGTTRLSDGPDWTFDLLDVYLAEIDRVAKLYRLDTYPHQIEVITSEQMMDAYSSVGMPINYPHWSFGKKFIETERLYKHGQQGLAYEIVINSNPCIAYLMEENTITMQALVMAHACYGHNSFFKNNYLFRSWTDASSIVDYLIFARKYITECEERYGVDEVERLLDSCHALMNYGVDRYKRPQKISLQEEKARQKSREEYLQSQVNMLWRTLPKREEEKTVAEARRYPSEPQENLLYFMEKNAPLLESWQREILRIVRKVSQYFYPQKQTQVMNEGWATFWHYTILNHLYDEGKVTERFMLEFLHSHTNVVFQPPYNSPWYSGINPYALGFAMFQDIKRICQSPTEEDKYWFPDIAGSDWLETLHFAMRDFKDESFISQFLSPKVMRDFRFFTVLDDDRHNYLEISAIHNEEGYREIRNRLSSQYNLSNLEPNIQIWNVDLRGDRSLTLRYIPHNRAPLDRGRKEVLKHVHRLWGFDVMLEQQNEDGSVELLERCPPRMGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H34</accession>
    <name>Q32H34_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402862.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H34"/>
    <dbReference type="EnsemblBacteria" id="ABB61371">
        <property type="protein sequence ID" value="ABB61371"/>
        <property type="gene ID" value="SDY_1218"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1218"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1446"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15334" checksum="465065E1864758B1" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNAKTGGVLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H77</accession>
    <name>Q32H77_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trimethylamine-N-oxide reductase</fullName>
            <ecNumber evidence="4">1.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">bisZ</name>
        <name evidence="11" type="ordered locus">SDY_1171</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.3" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402819.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H77"/>
    <dbReference type="STRING" id="300267.SDY_1171"/>
    <dbReference type="EnsemblBacteria" id="ABB61328">
        <property type="protein sequence ID" value="ABB61328"/>
        <property type="gene ID" value="SDY_1171"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1171"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1380"/>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_6"/>
    <dbReference type="OMA" id="DQMPKHV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050626">
        <property type="term" value="F:trimethylamine-N-oxide reductase (cytochrome c) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02793">
        <property type="entry name" value="MopB_CT_DMSOR-BSOR-TMAOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041954">
        <property type="entry name" value="CT_DMSOR/BSOR/TMAOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041460">
        <property type="entry name" value="Molybdopterin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18364">
        <property type="entry name" value="Molybdopterin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Molybdopterin_N" evidence="10">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Molybdopterin" evidence="8">
        <location>
            <begin position="90"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Molybdopterin" evidence="8">
        <location>
            <begin position="215"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="9">
        <location>
            <begin position="647"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB61328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="786" mass="86589" checksum="5CE4908DBF273C60" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HC6</accession>
    <name>Q32HC6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type arabinose transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">araH</name>
        <name evidence="8" type="ordered locus">SDY_1122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402770.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HC6"/>
    <dbReference type="STRING" id="300267.SDY_1122"/>
    <dbReference type="EnsemblBacteria" id="ABB61279">
        <property type="protein sequence ID" value="ABB61279"/>
        <property type="gene ID" value="SDY_1122"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1122"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1322"/>
    <dbReference type="HOGENOM" id="CLU_028880_4_1_6"/>
    <dbReference type="OMA" id="VFTTITN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="329" mass="34241" checksum="8380A73C925B3C29" modified="2005-12-06" version="1">MMSSVSTSGSGAPKSSFSFGRIWDQYGMLVVFAVLFIACAIFVPNFATFINMKGLGLAISMSGMGACGMLFCLASGDFDLSVASVIACAGVTTAVVINLTESLWIGVAAGLLLGVLCGLVNGFVIAKLKINALITTLATMQIVRGLAYIISDGKAVGIEDESFFALGYANWFGLPAPIWLTVACLIIFGLLLNKTTFGRNTLAIGGNEEAARLAGVPVVRTKIIIFVLSGLVSAIAGIILASRMTSGQPMTSIGYELIVISACVLGGVSLKGGIGKISYVVAGILILGTVENAMNLLNISPFAQYVVRGLILLAAVIFDRYKQKAKPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HK7</accession>
    <name>Q32HK7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZinT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_1033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001007762.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402689.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HK7"/>
    <dbReference type="STRING" id="300267.SDY_1033"/>
    <dbReference type="EnsemblBacteria" id="ABB61198">
        <property type="protein sequence ID" value="ABB61198"/>
        <property type="gene ID" value="SDY_1033"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1033"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1207"/>
    <dbReference type="HOGENOM" id="CLU_072001_1_0_6"/>
    <dbReference type="OMA" id="MGNTSHE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015304">
        <property type="entry name" value="ZinT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09223">
        <property type="entry name" value="ZinT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221108" description="ZinT domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ZinT" evidence="3">
        <location>
            <begin position="37"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="216" mass="24720" checksum="E22F98DF440ED5B0" modified="2005-12-06" version="1">MAIRLHKLAVALGVFIVSAPAFSHGHHSHGKPLTEVEQKAANGVFDDANVQNRTLSDWDGVWQSVYPLLQSGKLDPVFQKKADADKTKTFAEIKDYYHKGYATDIEMIGIEDGIVEFHRNNETTSCKYDYDGYKILTYKSGKKGVRYLFECKVPESKAPKYIQFSDHIIAPRKSSHFHIFMGNDSQQSLLNEMENWPTYYPYQLSSEEVVEEMMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HP3</accession>
    <name>Q32HP3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HP3"/>
    <dbReference type="EnsemblBacteria" id="ABB61162">
        <property type="protein sequence ID" value="ABB61162"/>
        <property type="gene ID" value="SDY_0995"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0995"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="OMA" id="INIRFYC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="94" mass="10915" checksum="999512375602FF11" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRIERNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HR9</accession>
    <name>Q32HR9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspH</name>
        <name evidence="4" type="ordered locus">SDY_0964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000087763.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402627.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
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    <dbReference type="AlphaFoldDB" id="Q32HR9"/>
    <dbReference type="SMR" id="Q32HR9"/>
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    <dbReference type="EnsemblBacteria" id="ABB61136">
        <property type="protein sequence ID" value="ABB61136"/>
        <property type="gene ID" value="SDY_0964"/>
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    <dbReference type="GeneID" id="58461179"/>
    <dbReference type="KEGG" id="sdy:SDY_0964"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1112"/>
    <dbReference type="HOGENOM" id="CLU_117621_2_1_6"/>
    <dbReference type="OMA" id="RIEFCRI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
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    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
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    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
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    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="70" mass="7720" checksum="8825CE2FCB1459CE" modified="2005-12-06" version="1">MSRKMTGIVKTFDRKSGKGFIIPSDGRKEVQVHISAFTPRDAEVLIPGLRVEFCRVNGLRGPTAANVYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HV6</accession>
    <name>Q32HV6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Paraquat-inducible protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pqiA</name>
        <name evidence="9" type="ordered locus">SDY_0923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of a transport pathway that contributes to membrane integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PqiA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000333170.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402590.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HV6"/>
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    <dbReference type="EnsemblBacteria" id="ABB61099">
        <property type="protein sequence ID" value="ABB61099"/>
        <property type="gene ID" value="SDY_0923"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0923"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1069"/>
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    <dbReference type="OMA" id="PWMMADV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PqiA-like"/>
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        <property type="entry name" value="PqiA-like_Ent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04403">
        <property type="entry name" value="PqiA"/>
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        <property type="entry name" value="pqiA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="417" mass="46433" checksum="E34BCD23F528CA5D" modified="2005-12-06" version="1">MCEHHHAAKHILCSQCDMLVALPRLEHGQKAACPRCGTTLTVAWDAPRQRPTAYALAALFMLLLSNLFPFVNMNVAGVTSEITLLEIPGVLFSEDYASLGTFFLLFVQLVPAFCLITILLLVNRAELPVRLKEQLARVLFQLKTWGMAEIFLAGVLVSFVKLMAYGSIGVGSSFLPWCLFCVLQLRAFQCVDRRWLWDDIAPMPELRQPLKPGVTGIRQGLRSCSCCTAILPADEPVCPRCGTKGYVRRRNSLQWTLALLVTSIMLYLPANILPIMVTDLLGSKMPSTILAGVILLWSEGSYPVAAVIFLASIMVPTLKMIAIAWLCWDAKGHGKRDSERMHLIYEVVEFVGRWSMIDVFVIAVLSALVRMGGLMSIYPAMGALMFALVVIMTMFSAMTFDPRLSWDRQPESEHEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HZ6</accession>
    <name>Q32HZ6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c-type biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ccmF</name>
        <name evidence="10" type="ordered locus">SDY_0882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000982407.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402550.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HZ6"/>
    <dbReference type="STRING" id="300267.SDY_0882"/>
    <dbReference type="EnsemblBacteria" id="ABB61059">
        <property type="protein sequence ID" value="ABB61059"/>
        <property type="gene ID" value="SDY_0882"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0882"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1017"/>
    <dbReference type="HOGENOM" id="CLU_015041_2_0_6"/>
    <dbReference type="OMA" id="SYWGMQL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032523">
        <property type="entry name" value="CcmF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003567">
        <property type="entry name" value="Cyt_c_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003568">
        <property type="entry name" value="Cyt_c_biogenesis_CcmF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43653">
        <property type="entry name" value="PTHR43653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16327">
        <property type="entry name" value="CcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01410">
        <property type="entry name" value="CCBIOGENESIS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01411">
        <property type="entry name" value="CCMFBIOGNSIS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00353">
        <property type="entry name" value="nrfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="8">
        <location>
            <begin position="89"/>
            <end position="296"/>
        </location>
    </feature>
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        <location>
            <begin position="316"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="647" mass="71409" checksum="9C4A7D429F385362" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I05</accession>
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        <submittedName>
            <fullName evidence="5">Ferredoxin-type protein</fullName>
        </submittedName>
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        <name evidence="5" type="ordered locus">SDY_0873</name>
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        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402541.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I05"/>
    <dbReference type="STRING" id="300267.SDY_0873"/>
    <dbReference type="EnsemblBacteria" id="ABB61050">
        <property type="protein sequence ID" value="ABB61050"/>
        <property type="gene ID" value="SDY_0873"/>
    </dbReference>
    <dbReference type="GeneID" id="67416641"/>
    <dbReference type="KEGG" id="sdy:SDY_0873"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1008"/>
    <dbReference type="HOGENOM" id="CLU_077329_0_0_6"/>
    <dbReference type="OMA" id="LIDHETC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004494">
        <property type="entry name" value="MauM_NapG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00397">
        <property type="entry name" value="mauM_napG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="231" mass="24925" checksum="9DA55774D6A68AD5" modified="2005-12-06" version="1">MSRSAKPQNGRRRFLRDVVRTAGGLAAVGVALGLQQQTARASGVRLRPPGAINENAFASACVRCGQCVQACPYDTLKLATLASGLSAGTPYFVARDIPCEMCEDIPCAKVCPSGALDREIESIDDARMGLAVLVDQENCLNFQGLRCDVCYRECPKIDEAITLELERNTRTGKHARFLPTVHSDACTGCGKCEKVCVLEQPAIKVLPLSLAKGELGHHYRFGWLEGNNGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I95</accession>
    <name>Q32I95_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CitMHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ybiR</name>
        <name evidence="8" type="ordered locus">SDY_0778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I95"/>
    <dbReference type="STRING" id="300267.SDY_0778"/>
    <dbReference type="EnsemblBacteria" id="ABB60962">
        <property type="protein sequence ID" value="ABB60962"/>
        <property type="gene ID" value="SDY_0778"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0778"/>
    <dbReference type="HOGENOM" id="CLU_063025_1_0_6"/>
    <dbReference type="OMA" id="IAMFIDV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="321" mass="35521" checksum="BD81D01F12B66398" modified="2005-12-06" version="1">MLLTKGVELSGYFDVLGRKMVRRFATERRLAMFMVLTAALLSTFLTNDVALFIVVPLTITLKRLCEIPVNRLIIFEALAVNAGSLLTPIGNPQNILIWGCSGLSFAGFIAQMAPLAGAMMLTLLLLCWCCFPGKALQYHTGVQTPEWKPRLVWSCLGLYIVFLTALEFKQELWGLVIVAVGFALLARRVVLSVDWTLLLVFMAMFIDVHLLTQLPALQGVLGNVSHLSEPGLWLTAIGLSQVISNVPSTILLLNYVPSSLLLAWAVNVGGFGLLPGSLANLIALRMANDRRIWWRFHLYSIPMLLWAVLVGYVLLVMIPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IF4</accession>
    <name>Q32IF4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0719</name>
        <name evidence="2" type="ordered locus">SDY_1029</name>
        <name evidence="3" type="ordered locus">SDY_1931</name>
        <name evidence="4" type="ordered locus">SDY_2295</name>
        <name evidence="5" type="ordered locus">SDY_3861</name>
        <name evidence="6" type="ordered locus">SDY_4494</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0719"/>
    <dbReference type="EnsemblBacteria" id="ABB60903">
        <property type="protein sequence ID" value="ABB60903"/>
        <property type="gene ID" value="SDY_0719"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61194">
        <property type="protein sequence ID" value="ABB61194"/>
        <property type="gene ID" value="SDY_1029"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62037">
        <property type="protein sequence ID" value="ABB62037"/>
        <property type="gene ID" value="SDY_1931"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62372">
        <property type="protein sequence ID" value="ABB62372"/>
        <property type="gene ID" value="SDY_2295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63803">
        <property type="protein sequence ID" value="ABB63803"/>
        <property type="gene ID" value="SDY_3861"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64370">
        <property type="protein sequence ID" value="ABB64370"/>
        <property type="gene ID" value="SDY_4494"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0719"/>
    <dbReference type="KEGG" id="sdy:SDY_1029"/>
    <dbReference type="KEGG" id="sdy:SDY_1931"/>
    <dbReference type="KEGG" id="sdy:SDY_2295"/>
    <dbReference type="KEGG" id="sdy:SDY_3861"/>
    <dbReference type="KEGG" id="sdy:SDY_4494"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_11_6"/>
    <dbReference type="OMA" id="GCSNEPR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="116" mass="13216" checksum="4102333D16F62F52" modified="2005-12-06" version="1">MVTLCHVFGVHRSSYRYWKNRPEKPDGRRAVLRSQVLELHGISHGSAGARSIATMATRRGYQMGRWLAGRLMKELGLVSCQQPTRRYKRGGHEHVAIPNYLERQFAGDRAKSGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IK4</accession>
    <name>Q32IK4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex</fullName>
            <ecNumber evidence="5 10">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">sucB</name>
        <name evidence="14" type="ordered locus">SDY_0665</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="10">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5 10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000099820.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402342.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IK4"/>
    <dbReference type="STRING" id="300267.SDY_0665"/>
    <dbReference type="EnsemblBacteria" id="ABB60853">
        <property type="protein sequence ID" value="ABB60853"/>
        <property type="gene ID" value="SDY_0665"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0665"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.776"/>
    <dbReference type="HOGENOM" id="CLU_016733_0_0_6"/>
    <dbReference type="OMA" id="MKVPSPG"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="113"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB60853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="405" mass="44017" checksum="A4AC801E2550B1F9" modified="2005-12-06" version="1">MSSVDILVPDLPESVADATVATWHKKPGDAVVRDEVLVEIETDKVVLEVPASADGILDAVLEDEGTTVTSRQILGRLREGNSAGKETSAKSEEKASTPAQRQQASLEEQNNDALSPAIRRLLAEHNLDASAIKGTGVGGRLTREDVEKHLAKAPAKESALAAAASAAQPALAARSEKRVPMTRLRKRVAERLLEAKNSTAMLTTFNEVNMKPIMDLRKQYGEAFEKRHGIRLGFMSFYVKAVVEALKRYPEVNASIDGDDVVYHNYFDVSMAVSTPRGLVTPVLRDVDTLGMADIEKKIKELAVKGRDGKLTVEDLTGGNFTITNGGVFGSLMSTPIINPPQSAILGMHAIKDRPMAVNGQVEILPMMYLALSYDHRLIDGRESVGFLVTIKELLEDPTRLLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IL4</accession>
    <name>Q32IL4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fimbrial-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybgD</name>
        <name evidence="3" type="ordered locus">SDY_0655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000472401.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402332.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IL4"/>
    <dbReference type="STRING" id="300267.SDY_0655"/>
    <dbReference type="EnsemblBacteria" id="ABB60843">
        <property type="protein sequence ID" value="ABB60843"/>
        <property type="gene ID" value="SDY_0655"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0655"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.766"/>
    <dbReference type="HOGENOM" id="CLU_088965_3_2_6"/>
    <dbReference type="OMA" id="DINLENC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000259">
        <property type="entry name" value="Adhesion_dom_fimbrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00419">
        <property type="entry name" value="Fimbrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220866" evidence="1">
        <location>
            <begin position="24"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Fimbrial" evidence="2">
        <location>
            <begin position="31"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="188" mass="19973" checksum="B013FBB0F15F73CC" modified="2005-12-06" version="1">MFKGQKTLAALAISLLFASPVFAADEGSGEIHFKGEVIEAPCEIHPDDLDMNIDLGEVTTSHINREHHSEKKPVNIRLINCDIAGWDDGNGGVVSKVGVTFDSTAKTTGATPLLSNISAGEATGVGIRLMNKDESFVVLGTEAPTIDLLASSTEQTLNFFAWMEQMDNAVSVTAGAVTANATYVLDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IN8</accession>
    <name>Q32IN8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybfF</name>
        <name evidence="2" type="ordered locus">SDY_0626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000773288.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402308.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IN8"/>
    <dbReference type="SMR" id="Q32IN8"/>
    <dbReference type="STRING" id="300267.SDY_0626"/>
    <dbReference type="ESTHER" id="shifl-YBFF">
        <property type="family name" value="ABHD11-Acetyl_transferase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60819">
        <property type="protein sequence ID" value="ABB60819"/>
        <property type="gene ID" value="SDY_0626"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0626"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.727"/>
    <dbReference type="HOGENOM" id="CLU_020336_53_1_6"/>
    <dbReference type="OMA" id="MMYFARK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="254" mass="28437" checksum="8B2F6E28713D9B8A" modified="2005-12-06" version="1">MKLNIRAQTAQNQHNNSPIVLVHGLFGSLDNLGVLARDLVNDHNIIQVDMRNHGLSPRDPVMNYPAMAQDLVDTLDAQQIDKATFIGHSMGGKAVMALTALASDRIDKLVAIDIAPVDYHVRRHDEIFAAINAVSESDAQTRQQAAAIMRQHLNEEGVIQFLLKSFVDGEWRFNVPVLWDQYPHIVGWEKIPAWDHPALFIPGGNSPYVSEQYRDDLLAQFPQARAHVIAGAGHWVHAEKPDAVLRAIRRYLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J15</accession>
    <name>Q32J15_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative flagellar motor transmembrane channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SDY_0485</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402181.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J15"/>
    <dbReference type="STRING" id="300267.SDY_0485"/>
    <dbReference type="EnsemblBacteria" id="ABB60692">
        <property type="protein sequence ID" value="ABB60692"/>
        <property type="gene ID" value="SDY_0485"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0485"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.572"/>
    <dbReference type="HOGENOM" id="CLU_068213_0_1_6"/>
    <dbReference type="OMA" id="MGIIITM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022522">
        <property type="entry name" value="Flagellar_motor_stator_MotA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30433:SF4">
        <property type="entry name" value="PTHR30433:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="11">
        <location>
            <begin position="88"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB60692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="247" mass="27099" checksum="8712CEE55BC43298" modified="2005-12-06" version="1">MAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITLEMVQNGGLRMLDQHIEQPEESTIFQKYPLVLTQKRLVTFIADNFRLMAMGKIDAHELEGILDQELDTAEESLLTPSRSLQRTAEAMPGFGICAAVLGIIITMQSIDGSIALIGLKVAAALVGTFLGVFICYCLMDPLANAMEQQARAEHSLLECVRTVLVAQAGGKPTLLAVDAGRKLLHLASKPTFANLDAWVNAMLEQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J17</accession>
    <name>DPO4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase IV</fullName>
            <shortName evidence="1">Pol IV</shortName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dinB</name>
        <name type="ordered locus">SDY_0483</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001226160.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402179.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J17"/>
    <dbReference type="SMR" id="Q32J17"/>
    <dbReference type="STRING" id="300267.SDY_0483"/>
    <dbReference type="EnsemblBacteria" id="ABB60690">
        <property type="protein sequence ID" value="ABB60690"/>
        <property type="gene ID" value="SDY_0483"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0483"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.570"/>
    <dbReference type="HOGENOM" id="CLU_012348_1_2_6"/>
    <dbReference type="OMA" id="CKPDGLL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0515">Mutator protein</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000084940" description="DNA polymerase IV">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <sequence length="351" mass="39480" checksum="03DF4277A463131A" modified="2005-12-06" version="1">MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRERRGVISTANYPARKFGVRSAMPTGMALKLCPHLTLLPGRFDAYKEASNHIREIFSRYTSRIEPLSLDEAYLDVTDSVHCHGSATLIAQEIRQTIFNELQLTASAGVAPVKFLAKIASDMNKPNGQFVITPAEVPAFLQTLPLAKIPGVGKVSAAKLEAIGLRTCGDVQKCDLVILLKRFGKFGRILWERSQGIDERDVNSERLRKSVGVERTMAEDIHHWSECEAIIERLYPELERRLAKVKPDLLIARQGVKLKFDDFQQTTQEHVWPRLNKADLIATARKTWDERRGGRGVRLVGLHVTLLDPQMERQLVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J39</accession>
    <name>Q32J39_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ylaD</name>
        <name evidence="5" type="ordered locus">SDY_0460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000102564.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402157.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J39"/>
    <dbReference type="SMR" id="Q32J39"/>
    <dbReference type="STRING" id="300267.SDY_0460"/>
    <dbReference type="EnsemblBacteria" id="ABB60668">
        <property type="protein sequence ID" value="ABB60668"/>
        <property type="gene ID" value="SDY_0460"/>
    </dbReference>
    <dbReference type="GeneID" id="58460091"/>
    <dbReference type="KEGG" id="sdy:SDY_0460"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.543"/>
    <dbReference type="HOGENOM" id="CLU_051638_3_3_6"/>
    <dbReference type="OMA" id="DCQIGPN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="183" mass="20096" checksum="3E4C7A4D68AA49C4" modified="2005-12-06" version="1">MSTEKEKMIAGELYRSADETLSRDRLRARQLIHRYNHSLAEEHTLRQQILADLFGQVTEAYIEPTFRCDYGYNIFLGNNFFANFDCVMLDVCPIRIGDNCMLAPGVHIYTATHPIDPVARNSGAELGKPVTIGNNVWIGGRAVINPGVTIGDNVVVASGAVVTKDVPDNVVVGGNPARIIKKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J49</accession>
    <name>APT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="1">APRT</shortName>
            <ecNumber evidence="1">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">apt</name>
        <name type="ordered locus">SDY_0450</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000127356.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402147.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J49"/>
    <dbReference type="SMR" id="Q32J49"/>
    <dbReference type="STRING" id="300267.SDY_0450"/>
    <dbReference type="EnsemblBacteria" id="ABB60658">
        <property type="protein sequence ID" value="ABB60658"/>
        <property type="gene ID" value="SDY_0450"/>
    </dbReference>
    <dbReference type="GeneID" id="66671229"/>
    <dbReference type="KEGG" id="sdy:SDY_0450"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.533"/>
    <dbReference type="HOGENOM" id="CLU_063339_3_0_6"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00103">
        <property type="entry name" value="PUR_PYR_PR_TRANSFER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000000339" description="Adenine phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <sequence length="183" mass="19859" checksum="AB45F0B5A219480D" modified="2005-12-06" version="1">MTATAQQLEYLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIDLLVERYKNAGITKVVGTEARGFLFGAPVALGLGVGFVPVRKPGKLPRETISETYDLEYGTDQLEIHVDAIKPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVADAAFIINLFDLGGEQRLEKQGITSYSLVPFPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J78</accession>
    <name>Q32J78_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J78"/>
    <dbReference type="STRING" id="300267.SDY_0418"/>
    <dbReference type="EnsemblBacteria" id="ABB60629">
        <property type="protein sequence ID" value="ABB60629"/>
        <property type="gene ID" value="SDY_0418"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0418"/>
    <dbReference type="HOGENOM" id="CLU_2013710_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="123" mass="13684" checksum="2D1BE5ECFD14FC0D" modified="2005-12-06" version="1">MITRRDNHDNISVQFSGDEGLETTLNVADVEDKIVELALLRPLSAIPDARVDDYIRPYQANWFWNLSLKDWRRYGDIMLASLVANVLALAAMIFSMQVYSGGSCAVLSDAMGAFRRGDDGDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JA5</accession>
    <name>Q32JA5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tesB</name>
        <name evidence="3" type="ordered locus">SDY_0389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000076838.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402091.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JA5"/>
    <dbReference type="STRING" id="300267.SDY_0389"/>
    <dbReference type="EnsemblBacteria" id="ABB60602">
        <property type="protein sequence ID" value="ABB60602"/>
        <property type="gene ID" value="SDY_0389"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0389"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.461"/>
    <dbReference type="HOGENOM" id="CLU_032690_0_0_6"/>
    <dbReference type="OMA" id="SQVWFRT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00189">
        <property type="entry name" value="tesB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="286" mass="32066" checksum="416393EB996577FA" modified="2005-12-06" version="1">MSQELKNLLTLLNLEKIEEGLFRGQSEDLGLRQVFGGQVVGQALYAAKETVPEERLVHSFHSYFLRPGDSKKPIIYDVETLRDGNSFSARRVAAIQNGKPIFYMTASFQAPEAGFEHQKIMPSAPAPDSLPSETQIAQSLAHLLPPVLKDKFICDRPLEVRPVEFHNPLKGHVAEPHRQVWIRANGSVPDDLRVHQYLLGYASDLNFLPVALQPHGIGFLEPGIQIATIDHSMWFHRPFNLNEWLLYSVESTSASSARGFVRGEFYTQDGVLVASTVQEGVMRNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JI3</accession>
    <name>Q32JI3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4 9">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">apbA</name>
        <name evidence="12" type="ordered locus">SDY_0305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4 9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000705855.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402013.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JI3"/>
    <dbReference type="STRING" id="300267.SDY_0305"/>
    <dbReference type="EnsemblBacteria" id="ABB60524">
        <property type="protein sequence ID" value="ABB60524"/>
        <property type="gene ID" value="SDY_0305"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0305"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.350"/>
    <dbReference type="HOGENOM" id="CLU_031468_0_1_6"/>
    <dbReference type="OMA" id="NYSSMYQ"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="10">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="11">
        <location>
            <begin position="168"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB60524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="303" mass="33871" checksum="7B24B5A31DFF8461" modified="2005-12-06" version="1">MKITVLGCGALGQLWLTALCKQGHEVQGWLRVPQPYCSVNLVETDGSIFNESLTANDPDFLATSDLLLVTLKAWQVSDAVKSLASTLPVTTPILLIHNGMGTIEELKNIQQPLLMGTTTHAARRDGNVIIHVANGITHIGPARQQDGDYSYLADILQTVLPDVAWHNNIRAELWRKLAVNCVINPLTAIWNCPNGELRHHPQEIMQICEEVAAVIEREGHHTSAEDLRDYVMQVIDATAENISSMLQDIRALRHTEIDYINGFLLRRARAHGIAVPENTRLFEMVKRKESEYERIGTGLPRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JM3</accession>
    <name>Q32JM3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JM3"/>
    <dbReference type="STRING" id="300267.SDY_0263"/>
    <dbReference type="EnsemblBacteria" id="ABB60484">
        <property type="protein sequence ID" value="ABB60484"/>
        <property type="gene ID" value="SDY_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0263"/>
    <dbReference type="HOGENOM" id="CLU_173908_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="82" mass="8974" checksum="09C9ED7E89EEBF18" modified="2005-12-06" version="1">MDKLTAEQRERYLQASADCQSSAPASGIVYELFVAGKGKTFTAKPKPDAEIASLLAKRSSCGKDTLYFSLRYLPVAHGILEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JR7</accession>
    <name>Q32JR7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yaeQ</name>
        <name evidence="1" type="ordered locus">SDY_0209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001185307.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401929.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JR7"/>
    <dbReference type="STRING" id="300267.SDY_0209"/>
    <dbReference type="EnsemblBacteria" id="ABB60440">
        <property type="protein sequence ID" value="ABB60440"/>
        <property type="gene ID" value="SDY_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0209"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.243"/>
    <dbReference type="HOGENOM" id="CLU_096741_0_0_6"/>
    <dbReference type="OMA" id="WIELGQP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009822">
        <property type="entry name" value="YaeQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038590">
        <property type="entry name" value="YaeQ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38784">
        <property type="entry name" value="PTHR38784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07152">
        <property type="entry name" value="YaeQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011484">
        <property type="entry name" value="YaeQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01322">
        <property type="entry name" value="YaeQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="181" mass="20908" checksum="A2DDA535CED1F931" modified="2005-12-06" version="1">MALKATIYKATVNVADLDRNQFLDASLTLVRHSSETQERMMLRLLAWLKYADERLQFTRGLCADDEPEAWLRNDHLGIDLWIELGLPDERRIKKACTQAAEVVLFTYNSRAAQIWWQQNQSKCVQFANLSVWYLDDEQLAKVSAFADRTMTLLATIQDGVIWLSDDKNNLEVNLTAWQQPS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JS6</accession>
    <name>RNH2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease HII</fullName>
            <shortName evidence="1">RNase HII</shortName>
            <ecNumber evidence="1">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnhB</name>
        <name type="ordered locus">SDY_0199</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000569431.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401920.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JS6"/>
    <dbReference type="SMR" id="Q32JS6"/>
    <dbReference type="STRING" id="300267.SDY_0199"/>
    <dbReference type="EnsemblBacteria" id="ABB60431">
        <property type="protein sequence ID" value="ABB60431"/>
        <property type="gene ID" value="SDY_0199"/>
    </dbReference>
    <dbReference type="GeneID" id="58388403"/>
    <dbReference type="KEGG" id="sdy:SDY_0199"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.230"/>
    <dbReference type="HOGENOM" id="CLU_036532_3_2_6"/>
    <dbReference type="OMA" id="YPTKLHL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000235764" description="Ribonuclease HII">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <sequence length="198" mass="21552" checksum="25350722EB411414" modified="2005-12-06" version="1">MIEFVYPHTQLVAGVDEVGRGPLVGAVVTAAVILDPARPIAGLNDSKKLSEKRRLALYEEIKEKALSWSLGRAEPHEIDELNILHATMLAMQRAVAGLHIAPEYVLIDGNRCPKLPMPAMAVVKGDSRVPEISAASILAKVTRDAEMAALDIVFPQYGFAQHKGYPTAFHLEKLAEYGATEHHRRSFGPVKRALGLAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JU4</accession>
    <name>YAEH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0325 protein YaeH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yaeH</name>
        <name type="ordered locus">SDY_0181</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0325 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000272188.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401902.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JU4"/>
    <dbReference type="SMR" id="Q32JU4"/>
    <dbReference type="STRING" id="300267.SDY_0181"/>
    <dbReference type="EnsemblBacteria" id="ABB60413">
        <property type="protein sequence ID" value="ABB60413"/>
        <property type="gene ID" value="SDY_0181"/>
    </dbReference>
    <dbReference type="GeneID" id="67416240"/>
    <dbReference type="KEGG" id="sdy:SDY_0181"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.210"/>
    <dbReference type="HOGENOM" id="CLU_136774_0_0_6"/>
    <dbReference type="OMA" id="EHVVANK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01519">
        <property type="entry name" value="UPF0325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020911">
        <property type="entry name" value="UPF0325"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11944">
        <property type="entry name" value="DUF3461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000244254" description="UPF0325 protein YaeH">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01519"/>
        </source>
    </evidence>
    <sequence length="128" mass="15096" checksum="A765608D37C11C42" modified="2005-12-06" version="1">MYDNLKSLGITNPEEIDRYSLRQEANNDILKIYFQKDKGEFFAKSVKFKYPRQRKTVVADGVGQGYKEVQEISPNLRYIIDELDQICQRDRSEVDLKRKILDDLRHLESVVTNKISEIEADLEKLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K08</accession>
    <name>Q32K08_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidoglycan D,D-transpeptidase FtsI</fullName>
            <ecNumber evidence="7">3.4.16.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Penicillin-binding protein 3</fullName>
            <shortName evidence="7">PBP-3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ftsI</name>
        <name evidence="10" type="ordered locus">SDY_0114</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transpeptidase family. FtsI subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000642196.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401838.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K08"/>
    <dbReference type="SMR" id="Q32K08"/>
    <dbReference type="STRING" id="300267.SDY_0114"/>
    <dbReference type="EnsemblBacteria" id="ABB60349">
        <property type="protein sequence ID" value="ABB60349"/>
        <property type="gene ID" value="SDY_0114"/>
    </dbReference>
    <dbReference type="GeneID" id="66671626"/>
    <dbReference type="KEGG" id="sdy:SDY_0114"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.133"/>
    <dbReference type="HOGENOM" id="CLU_009289_6_2_6"/>
    <dbReference type="OMA" id="HGKEEYY"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02080">
        <property type="entry name" value="FtsI_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037532">
        <property type="entry name" value="FtsI_transpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0717">Septation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="9">
        <location>
            <begin position="70"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="8">
        <location>
            <begin position="260"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="588" mass="63877" checksum="C89A403D5980B2CD" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K28</accession>
    <name>THIQ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine import ATP-binding protein ThiQ</fullName>
            <ecNumber evidence="1">7.6.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiQ</name>
        <name type="ordered locus">SDY_0093</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in)</text>
            <dbReference type="Rhea" id="RHEA:29811"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.15" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000916326.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401818.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K28"/>
    <dbReference type="SMR" id="Q32K28"/>
    <dbReference type="STRING" id="300267.SDY_0093"/>
    <dbReference type="EnsemblBacteria" id="ABB60329">
        <property type="protein sequence ID" value="ABB60329"/>
        <property type="gene ID" value="SDY_0093"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0093"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.109"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="QSIVTFP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048502">
        <property type="term" value="F:ABC-type thiamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005968">
        <property type="entry name" value="Thiamine_ABC_ThiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01277">
        <property type="entry name" value="thiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51288">
        <property type="entry name" value="THIQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000274459" description="Thiamine import ATP-binding protein ThiQ">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01723"/>
        </source>
    </evidence>
    <sequence length="232" mass="25045" checksum="58EE6CF040236EBD" modified="2005-12-06" version="1">MLKLTDITWLYQHLPMRFSLTVERGEQVAILGPSGTGKSTLLNLIAGFLTPASGSLTIDGVDHTTTPPSRRPVSMLFQENNLFSHLTVAQNIGLGLNPGLKLNAAQQEKMHAIARQMGIDNLMARLPGELSGGQRQRVALARCLVRKQPILLLDEPFSALDPALRQEMLTLVSTSCQQQKMTLLMVSHSVEDAARIATRSVVVADGRIAWQGKTEELLSGKASASALLGITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K46</accession>
    <name>Q32K46_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Toxin CcdB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cytotoxic protein CcdB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein LetD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_0073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CcdB toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001160974.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401800.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K46"/>
    <dbReference type="EnsemblBacteria" id="ABB60311">
        <property type="protein sequence ID" value="ABB60311"/>
        <property type="gene ID" value="SDY_0073"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0073"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.83"/>
    <dbReference type="HOGENOM" id="CLU_158043_3_0_6"/>
    <dbReference type="OMA" id="HEMASIP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008657">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006276">
        <property type="term" value="P:plasmid maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002712">
        <property type="entry name" value="CcdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01845">
        <property type="entry name" value="CcdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="104" mass="11738" checksum="5B21680B57CB436A" modified="2005-12-06" version="1">MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFIRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALGTKFCDASAHRTLIKGALDFMLDGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KA5</accession>
    <name>DNAK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaK</name>
        <name type="ordered locus">SDY_0013</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000516135.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401741.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KA5"/>
    <dbReference type="SMR" id="Q32KA5"/>
    <dbReference type="STRING" id="300267.SDY_0013"/>
    <dbReference type="EnsemblBacteria" id="ABB60253">
        <property type="protein sequence ID" value="ABB60253"/>
        <property type="gene ID" value="SDY_0013"/>
    </dbReference>
    <dbReference type="GeneID" id="67416093"/>
    <dbReference type="KEGG" id="sdy:SDY_0013"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.13"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_6"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000226009" description="Chaperone protein DnaK">
        <location>
            <begin position="1"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="638" mass="69115" checksum="5A8589B21D7CD9C1" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q326U8</accession>
    <name>Q326U8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1294 ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_P147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406148.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326U8"/>
    <dbReference type="EnsemblBacteria" id="ABB64660">
        <property type="protein sequence ID" value="ABB64660"/>
        <property type="gene ID" value="SDY_P147"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P147"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5704"/>
    <dbReference type="HOGENOM" id="CLU_038153_0_0_6"/>
    <dbReference type="OMA" id="HIEDCRT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007069">
        <property type="entry name" value="Transposase_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026889">
        <property type="entry name" value="Zn_Tnp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04986">
        <property type="entry name" value="Y2_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14319">
        <property type="entry name" value="Zn_Tnp_IS91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS91" evidence="2">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="430" mass="48903" checksum="437B162623B3D358" modified="2005-12-06" version="1">MTRSGGDFQPRPLKRLFTTNQCWTSFLDAGGLRDIEVEAVTKMLACGTRILGVKEYNCDKPECPHVRYVTNSCGSRACPSCGKKATDLWIATQLNRLPDCDWVHLVFTLPDTLWPVFESNRWLLNDVCRLAVENLLYAARKRGQEPGIFCAIHTYGRRLNCHPHVHVSVTCGCLNKHGQWKKLSFLKDAMRSRWMWNMRQLLLKAWSEGLAMPESLSHITTESQWRSLVLKAGGKYWHVYMSKKTAGGRNTARYLGRYLKKPPIAASRLAHYNGGASLSFRYLDHKTGETATETLTQRELVARLKQHIPEKFFKMVRYFGFLANRVCGEKLPQVYRALGMDKPAPVAKVCYAQMVKQFLSRDPFECVLCGGRMVYRRAIAGRFTRLSVPEGTLGQWVTAARKGLNTPGSRTCHERCNSDPHPTPEIRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Y3</accession>
    <name>Q326Y3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406113.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Y3"/>
    <dbReference type="EnsemblBacteria" id="ABB64625">
        <property type="protein sequence ID" value="ABB64625"/>
        <property type="gene ID" value="SDY_P112"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P112"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5667"/>
    <dbReference type="HOGENOM" id="CLU_166156_0_0_6"/>
    <dbReference type="OMA" id="MIQAQEY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="102" mass="11738" checksum="D16C22D1317CDD0B" modified="2005-12-06" version="1">MIQAQEYIGAGYHWVVDLDLEKFFDRINHDVLMSRIEKRVSDKLVLSLIRRFLNAGVMDAGLVRPVTEGTPQGGVISPLLSNLFLHYAFDMWMQRQCPDVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Z3</accession>
    <name>Q326Z3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative IS orf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406103.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Z3"/>
    <dbReference type="EnsemblBacteria" id="ABB64615">
        <property type="protein sequence ID" value="ABB64615"/>
        <property type="gene ID" value="SDY_P102"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P102"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5656"/>
    <dbReference type="HOGENOM" id="CLU_179902_0_1_6"/>
    <dbReference type="OMA" id="MRFRNAG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="80" mass="8712" checksum="F6C3ABB386B86954" modified="2005-12-06" version="1">MAGCRLGVPKSTVCGMFVRFRNAGLSWPLPVGMSEQELDALLYGSASTVPVVLTESTVMPKLPVVKKRPRRPNADQLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q327H3</accession>
    <name>Q327H3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_P022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7 8">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Sd197</strain>
            <plasmid evidence="8">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406023.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327H3"/>
    <dbReference type="EnsemblBacteria" id="ABB64535">
        <property type="protein sequence ID" value="ABB64535"/>
        <property type="gene ID" value="SDY_P022"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P022"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5558"/>
    <dbReference type="HOGENOM" id="CLU_209678_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="68" mass="7666" checksum="19DD09CB6FC0DF0C" modified="2005-12-06" version="1">MDAENETVLNANMTHHLGCEKNQLRSGSNSRNGCLTKIITTGDEPLEIRTLRDRNGTFEPQQLKKNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q327J3</accession>
    <name>Q327J3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406003.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327J3"/>
    <dbReference type="EnsemblBacteria" id="ABB64516">
        <property type="protein sequence ID" value="ABB64516"/>
        <property type="gene ID" value="SDY_P002"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P002"/>
    <dbReference type="HOGENOM" id="CLU_2976798_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="58" mass="6644" checksum="67977E9AE7B860C9" modified="2005-12-06" version="1">MVHATGLMKHASSPGCWDFVEPKNTAVRSPESNRIAKSFVKPREYLRQRANDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q327L7</accession>
    <name>Q327L7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yjjW</name>
        <name evidence="11" type="ordered locus">SDY_4639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001088362.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405979.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327L7"/>
    <dbReference type="STRING" id="300267.SDY_4639"/>
    <dbReference type="EnsemblBacteria" id="ABB64488">
        <property type="protein sequence ID" value="ABB64488"/>
        <property type="gene ID" value="SDY_4639"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4639"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5499"/>
    <dbReference type="HOGENOM" id="CLU_058969_3_1_6"/>
    <dbReference type="OMA" id="CHNPHTI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023912">
        <property type="entry name" value="YjjW_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00392">
        <property type="entry name" value="YjjI_activase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04041">
        <property type="entry name" value="activase_YjjW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="17"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB64488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="287" mass="31351" checksum="06C4691A0198344F" modified="2005-12-06" version="1">MNSRCALVSKIIPFSCVDGPGSRLALFLQGCNLRCKNCHNPWTMGRCNDCGECVPQCPHQALQIIDGKVAWSAAVCEQCDTCLKMCPQHATPMAQSMSVDEVLNHVRKAVLFIEGITVSGGEATTQLPFVVALFTAIKNDPQLCHFTCLVDSNGMLSETGWEKLLPVCDGAMLDLKAWGSECHQQLTGRDNQQIKRSICLLAELGKLAELRLLVIPGQVDYLQHIEELAALIKGLDDVPVRLNAFHAHGVYGEAQSWPSATPEDVEPLADALKVRGVSRLIFPALYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q328G5</accession>
    <name>Q328G5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative synthetase/amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjfC</name>
        <name evidence="2" type="ordered locus">SDY_4403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000943974.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405781.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328G5"/>
    <dbReference type="STRING" id="300267.SDY_4403"/>
    <dbReference type="EnsemblBacteria" id="ABB64290">
        <property type="protein sequence ID" value="ABB64290"/>
        <property type="gene ID" value="SDY_4403"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4403"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5200"/>
    <dbReference type="HOGENOM" id="CLU_059175_0_0_6"/>
    <dbReference type="OMA" id="DEIYWDE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSP_synth" evidence="1">
        <location>
            <begin position="14"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="387" mass="45046" checksum="DD3D81E94D857E6E" modified="2005-12-06" version="1">MLRHNVPVRRDLDQIAADNGFDFHIIDNEIYWDESRAYRFTLRQIEEQIEKPTAELHQMCLEVVERAVKDEEILTQLAIPPLYWDVIAESWRARDPSLYGRMDFAWCGNAPVKLLEYNADTPTSLYESAYFQWLWLEDARRSGIIPRDADQYNAIQERLISRFSELYSREPFYFCCCQDTDEDRSTVLYLQDCAQQAGQESRFIYIEDLGLDVGGVLTDLDDNVIQRAFKLYPLEWMMRDDNGPLLRKRREQWVEPLWKSILSNKGLMPLLWRFFPGHPNLLASWFEGEKPQIAAGESYVRKPIYSREGGNVTIFDGQNNVVDHADGDYADEPMIYQAFQPLPRFGDSYTLIGSWIVDDEACGMGIREDNTLITKDTSRSVPHYIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q328K9</accession>
    <name>Q328K9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1471 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjfN</name>
        <name evidence="3" type="ordered locus">SDY_4357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405737.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328K9"/>
    <dbReference type="STRING" id="300267.SDY_4357"/>
    <dbReference type="EnsemblBacteria" id="ABB64246">
        <property type="protein sequence ID" value="ABB64246"/>
        <property type="gene ID" value="SDY_4357"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4357"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5145"/>
    <dbReference type="HOGENOM" id="CLU_158602_3_0_6"/>
    <dbReference type="OMA" id="EQQPDNW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036275">
        <property type="entry name" value="YdgH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010854">
        <property type="entry name" value="YdgH/BhsA/McbA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07338">
        <property type="entry name" value="DUF1471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159871">
        <property type="entry name" value="SSF159871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DUF1471" evidence="2">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="100" mass="10964" checksum="E6992BE85163086C" modified="2005-12-06" version="1">MGKRKMELTMKQLLASPSLQLVTCPASATAQSAEFASADCVTGLNEIGQISVSNISGDPQDVERIVALKADEQGASWYRIITMYEDQQPDNWRVQAILYA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q328N3</accession>
    <name>METAS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homoserine O-succinyltransferase</fullName>
            <shortName evidence="1">HST</shortName>
            <ecNumber evidence="1">2.3.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Homoserine transsuccinylase</fullName>
            <shortName evidence="1">HTS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metAS</name>
        <name type="ordered locus">SDY_4330</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:22008"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="EC" id="2.3.1.46"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-succinyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MetA family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.46" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001122782.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405713.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328N3"/>
    <dbReference type="SMR" id="Q328N3"/>
    <dbReference type="STRING" id="300267.SDY_4330"/>
    <dbReference type="EnsemblBacteria" id="ABB64222">
        <property type="protein sequence ID" value="ABB64222"/>
        <property type="gene ID" value="SDY_4330"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4330"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5113"/>
    <dbReference type="HOGENOM" id="CLU_057851_0_1_6"/>
    <dbReference type="OMA" id="WLWFCYQ"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008899">
        <property type="term" value="F:homoserine O-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019281">
        <property type="term" value="P:L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03131">
        <property type="entry name" value="GATase1_HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00295">
        <property type="entry name" value="MetA_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005697">
        <property type="entry name" value="HST_MetA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033752">
        <property type="entry name" value="MetA_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20919">
        <property type="entry name" value="PTHR20919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04204">
        <property type="entry name" value="HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000450">
        <property type="entry name" value="H_ser_succinyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01001">
        <property type="entry name" value="metA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000021844" description="Homoserine O-succinyltransferase">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for acyl-CoA specificity" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00295"/>
        </source>
    </evidence>
    <sequence length="309" mass="35727" checksum="E2D22E187274830A" modified="2005-12-06" version="1">MPIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESRNTPAEHLNNFYCNFEDIQEQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTRTDKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAQTLAQEFFRDVEAGLDPDVPYNYFPHNDPQNTPRASWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q328P9</accession>
    <name>Q328P9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pseudouridine synthase</fullName>
            <ecNumber evidence="5">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yjbC</name>
        <name evidence="8" type="ordered locus">SDY_4310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000936357.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405697.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328P9"/>
    <dbReference type="STRING" id="300267.SDY_4310"/>
    <dbReference type="EnsemblBacteria" id="ABB64206">
        <property type="protein sequence ID" value="ABB64206"/>
        <property type="gene ID" value="SDY_4310"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4310"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5086"/>
    <dbReference type="HOGENOM" id="CLU_024979_6_1_6"/>
    <dbReference type="OMA" id="NAHDKEY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S4" evidence="7">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="290" mass="32378" checksum="CA2E6704D46F11C7" modified="2005-12-06" version="1">MLPDSSVRLNKYISESGICSRREADRYIEQGNVFLNGKRATIGDQVKPGDVVKVNGQLIEPREAEDLVLIALNKPVGIVSTTEDGERDNIVDFVNHSKRVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLVTVDKPITDEFIRGMGAGVPILGTVTKKCKVKKEAPFVFRITLVQGLNRQIRRMCEHFGYEVKKLERTRIMNVSLNGIPLGEWRDLTDDELIDLFKLIENSSSEAKPKAKAKPKTAGIKRPVVKMEKTAEKGGCPASNGKRFTSPGRKKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q328V6</accession>
    <name>Q328V6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ytfT</name>
        <name evidence="8" type="ordered locus">SDY_4248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405640.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328V6"/>
    <dbReference type="STRING" id="300267.SDY_4248"/>
    <dbReference type="EnsemblBacteria" id="ABB64149">
        <property type="protein sequence ID" value="ABB64149"/>
        <property type="gene ID" value="SDY_4248"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4248"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5009"/>
    <dbReference type="HOGENOM" id="CLU_028880_3_0_6"/>
    <dbReference type="OMA" id="VWNGFLV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="309" mass="32126" checksum="0F2F16FB034BE9F8" modified="2005-12-06" version="1">MMPQSLPDTTPPKRRFRWPTGMPQLAALLLVLLVDSLVAPHFWQVVLQDGRLFGSPIDILNRAAPVALLAIGMTLVIATGGIDLSVGAVMAIAGATTAAMTVAGFSLPIVLLSALGTGILAGLWNGILVAILKIQPFVATLILMVAGRGVAQLITSGQIITFNSPDLSWFGSGSLLFLPTPVIIAVLTLILFWLLTRKTALGMFIEAVGINIRAAKNAGVNTRIIVMLTYVLSGLCAAIAGIIVAADIRGADANNAGLWLELDAILAVVIGGGSLMGGRFNLLFSVVGALIIQGMNTGILLSGFPPEMN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q329H3</accession>
    <name>PHNN_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose 1,5-bisphosphate phosphokinase PhnN</fullName>
            <ecNumber evidence="1">2.7.4.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribose 1,5-bisphosphokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">phnN</name>
        <name type="ordered locus">SDY_4122</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-ribose 1,5-bisphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:20109"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose 1,5-bisphosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000147004.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405523.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329H3"/>
    <dbReference type="SMR" id="Q329H3"/>
    <dbReference type="STRING" id="300267.SDY_4122"/>
    <dbReference type="EnsemblBacteria" id="ABB64032">
        <property type="protein sequence ID" value="ABB64032"/>
        <property type="gene ID" value="SDY_4122"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4122"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4846"/>
    <dbReference type="HOGENOM" id="CLU_102477_0_0_6"/>
    <dbReference type="OMA" id="RLIWLTG"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033863">
        <property type="term" value="F:ribose 1,5-bisphosphate phosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019634">
        <property type="term" value="P:organic phosphonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00836">
        <property type="entry name" value="PhnN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012699">
        <property type="entry name" value="PhnN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02322">
        <property type="entry name" value="phosphon_PhnN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000412800" description="Ribose 1,5-bisphosphate phosphokinase PhnN">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00836"/>
        </source>
    </evidence>
    <sequence length="185" mass="20689" checksum="FB8DD052F2E9B8BF" modified="2005-12-06" version="1">MTGKLIWLMGPSGSGKDSLLAELRLREQTQLLVAHRYITRDASAGSENHIALSEQEFFTRAGQNLLALSWHANGLYYGVGVEIDLWLHAGFDVLVNGSRAHLPQARARYQSALLPICLQVSPEILRQRLENRGRENASEINARLVRAARYTPQDCHTLNNDGSLCQSVDTLLTLIHQKEKHHACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q329P8</accession>
    <name>Q329P8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yibK</name>
        <name evidence="3" type="synonym">trmL</name>
        <name evidence="6" type="ordered locus">SDY_4039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000932351.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405448.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329P8"/>
    <dbReference type="STRING" id="300267.SDY_4039"/>
    <dbReference type="EnsemblBacteria" id="ABB63957">
        <property type="protein sequence ID" value="ABB63957"/>
        <property type="gene ID" value="SDY_4039"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4039"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4754"/>
    <dbReference type="HOGENOM" id="CLU_110125_1_0_6"/>
    <dbReference type="OMA" id="AGLDYWH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00185">
        <property type="entry name" value="tRNA_yibK_trmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="157" mass="17657" checksum="A41CEC83086D251A" modified="2005-12-06" version="1">MLNIVLYEPEIPPNTGNIIRLCANTGFRLHIIEPMGFAWDDKRLRRAGLDYHEFTAVTRHHDYSAFLEAENPQRLFALTTKGTPAHSAVSYQDGDYLMFGPETRGLPASILDALPAEQKIRIPMVPDSRSMNLSNAVSVVVYEAWRQLGYPGAVLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Q7</accession>
    <name>Q329Q7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_4030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405439.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Q7"/>
    <dbReference type="EnsemblBacteria" id="ABB63948">
        <property type="protein sequence ID" value="ABB63948"/>
        <property type="gene ID" value="SDY_4030"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4030"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4744"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14896" checksum="EB6A31D88C754B56" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQYLARLGRKSLSFSKSVELHDKVIGHYLNIQHCQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q329S6</accession>
    <name>ATPL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit c</fullName>
            <shortName evidence="1">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpE</name>
        <name type="ordered locus">SDY_4011</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000429386.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405420.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329S6"/>
    <dbReference type="SMR" id="Q329S6"/>
    <dbReference type="STRING" id="300267.SDY_4011"/>
    <dbReference type="EnsemblBacteria" id="ABB63929">
        <property type="protein sequence ID" value="ABB63929"/>
        <property type="gene ID" value="SDY_4011"/>
    </dbReference>
    <dbReference type="GeneID" id="64726533"/>
    <dbReference type="GeneID" id="67517226"/>
    <dbReference type="KEGG" id="sdy:SDY_4011"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4724"/>
    <dbReference type="HOGENOM" id="CLU_148047_1_0_6"/>
    <dbReference type="OMA" id="VTDGAFI"/>
    <dbReference type="PRO" id="PR:Q329S6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000184487" description="ATP synthase subunit c">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <sequence length="79" mass="8256" checksum="0F595A69D8AD1F9E" modified="2005-12-06" version="1">MENLNMDLLYMAAAVMMGLAAIGAAIGIGILGGKFLEGAARQPDLIPLLRTQFFIVMGLVDAIPMIAVGLGLYVMFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q329U0</accession>
    <name>Q329U0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator for rbs operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsR</name>
        <name evidence="5" type="ordered locus">SDY_3994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378918.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405406.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329U0"/>
    <dbReference type="STRING" id="300267.SDY_3994"/>
    <dbReference type="EnsemblBacteria" id="ABB63915">
        <property type="protein sequence ID" value="ABB63915"/>
        <property type="gene ID" value="SDY_3994"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3994"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4702"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_6"/>
    <dbReference type="OMA" id="IMQRYPS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="316" mass="35106" checksum="F4C9288A0CD50C61" modified="2005-12-06" version="1">MATMKDVARLAGVSTSTVSHVINKDRFVSEAITAKVEAAIKELNYAPSALARSLKLNQTHTIGMLITASTNPFYSELVRGVERSCFERGYSLVLCNTEGDEQRMNRNLETLMQKRVDGLLLLCTETHQPSREIMQRYPTVPTVMMDWAPFDGDRDLIQDNSLLGGDLATQYLIDKGHTRIACITGPLDKTPARLRLEGYRAAMKRAGLNIPDGYEVTGDFEFNGGFDAMRQLLSHPLRPQAVFTGNDAMAVGVYQALYQAELQVPQDIAVIGYDDIELASFMTPPLTTIHQPKDELGELAIDVLIHRIIQPPPQQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q329X2</accession>
    <name>WZYE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable ECA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">wzyE</name>
        <name type="ordered locus">SDY_3954</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Probably part of a complex composed of WzxE, WzyE and WzzE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WzyE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000055125.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405374.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329X2"/>
    <dbReference type="STRING" id="300267.SDY_3954"/>
    <dbReference type="EnsemblBacteria" id="ABB63883">
        <property type="protein sequence ID" value="ABB63883"/>
        <property type="gene ID" value="SDY_3954"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3954"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4665"/>
    <dbReference type="HOGENOM" id="CLU_049711_0_0_6"/>
    <dbReference type="OMA" id="WLWPDRP"/>
    <dbReference type="UniPathway" id="UPA00566"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009246">
        <property type="term" value="P:enterobacterial common antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01003">
        <property type="entry name" value="WzyE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010691">
        <property type="entry name" value="WzyE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06899">
        <property type="entry name" value="WzyE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000062764" description="Probable ECA polymerase">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01003"/>
        </source>
    </evidence>
    <sequence length="450" mass="51553" checksum="8C4447C905A0C063" modified="2005-12-06" version="1">MSLLQFSGLFVVWLLCTLFIATLTWFEFRRVRFNFNVFFSLLFLLTFFFGFPLTSVLVFRFDVGVAPPEILLQALLSAGCFYAVYYVTYKTRLRKRVADVPRRPLFTMNRVETNLTWMILMGIALVSVGIFFMHNGFLLFRLNSYSQIFSSEVSGVALKRFFYFFIPAMLVVYFLRQDSKAWLFFLVSTVAFGLLTYMIVGGTRANIIIAFAIFLFIGIIRGWISLWMLAAAGVLGIVGMFWLALKRYGMNVSGDEAFYTFLYLTRDTFSPWENLALLLQNYDNIDFQGLAPIVRDFYVFIPSWLWPGRPSMVLNSANYFTWEVLNNHSGLAISPTLIGSLVVMGGALFIPLGAIVVGLIIKWFDWLYELGNRETNRYKAAILHSFCFGAIFNMIVLAREGLDSFVSRVVFFIVVFGACLMIAKLLYWLFESAGLIHKRTKSSLRTQVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q329X4</accession>
    <name>Q329X4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative amino acid/amine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yifK</name>
        <name evidence="8" type="ordered locus">SDY_3952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000774731.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405372.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329X4"/>
    <dbReference type="SMR" id="Q329X4"/>
    <dbReference type="STRING" id="300267.SDY_3952"/>
    <dbReference type="EnsemblBacteria" id="ABB63881">
        <property type="protein sequence ID" value="ABB63881"/>
        <property type="gene ID" value="SDY_3952"/>
    </dbReference>
    <dbReference type="GeneID" id="66672301"/>
    <dbReference type="KEGG" id="sdy:SDY_3952"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4662"/>
    <dbReference type="HOGENOM" id="CLU_007946_9_3_6"/>
    <dbReference type="OMA" id="CIAYMNV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="16"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="461" mass="50399" checksum="62EE13158BC8EE3A" modified="2005-12-06" version="1">MADNKPELQRGLEARHIELIALGGTIGVGLFMGAASTLKWAGPSVLLAYIIAGLFVFFIMRSMGEMLFLEPVTGSFAVYAHRYMSPFFGYLTAWSYWFMWMAVGISEITAIGVYVQFWFPEMAQWIPALIAVALVALANLAAVRLYGEIEFWFAMIKVTTIIVMIVIGLGVIFFGFGNGGQSIGFSNLTEHGGFFAGGWKGFLTALCIVVASYQGVELIGITAGEAKNPQVTLRSAVGKVLWRILIFYVGAIFVIVTIFPWNEIGSNGSPFVLTFAKIGITAAAGIINFVVLTAALSGCNSGMYSCGRMLYALAKNRQLPAAMAKVSRHGVPVAGVAVSIAILLIGSCLNYIIPNPQRVFVYVYSASVLPGMVPWFVILISQLRFRRAHKAAIASHPFRSILFPWANYVTMAFLICVLIGMYFNEDTRMSLFVGIIFMLAVTAIYKVFGLNRHGKAHKLEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AB6</accession>
    <name>ARGB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetylglutamate kinase</fullName>
            <ecNumber evidence="1">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NAG kinase</fullName>
            <shortName evidence="1">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argB</name>
        <name type="ordered locus">SDY_3794</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AB6"/>
    <dbReference type="SMR" id="Q32AB6"/>
    <dbReference type="STRING" id="300267.SDY_3794"/>
    <dbReference type="EnsemblBacteria" id="ABB63739">
        <property type="protein sequence ID" value="ABB63739"/>
        <property type="gene ID" value="SDY_3794"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3794"/>
    <dbReference type="HOGENOM" id="CLU_053680_1_1_6"/>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04249">
        <property type="entry name" value="AAK_NAGK-NC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041731">
        <property type="entry name" value="NAGK-NC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000264759" description="Acetylglutamate kinase">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <sequence length="258" mass="27202" checksum="94857B8FAC133738" modified="2005-12-06" version="1">MMNPLIIKLGGVLLDSEEALERLFSALVNYRESHQRPLVIVHGGGCVVDELMKGLNLPVKKKNGLRVTPADQIDIITGALAGTANKTLLAWAKKHQIAAVGLFLGDGDSVKVTQLDEELGHVGLAQPGSPKLINTLLENGYLPVVSSIGVTDEGQLMNVNADQAATALAATLGADLILLSDVSGILDGKGQRIAEMTAAKAEQLIEQGIITDGMIVKVNAALDAARTLGRPVDIASWRHAEQLPALFNGMPMGTRILV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AD6</accession>
    <name>METJ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Met repressor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Met regulon regulatory protein MetJ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metJ</name>
        <name type="ordered locus">SDY_3773</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>Does not bind DNA by a helix-turn-helix motif.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MetJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000852812.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405210.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AD6"/>
    <dbReference type="SMR" id="Q32AD6"/>
    <dbReference type="STRING" id="300267.SDY_3773"/>
    <dbReference type="EnsemblBacteria" id="ABB63719">
        <property type="protein sequence ID" value="ABB63719"/>
        <property type="gene ID" value="SDY_3773"/>
    </dbReference>
    <dbReference type="GeneID" id="67417544"/>
    <dbReference type="KEGG" id="sdy:SDY_3773"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4462"/>
    <dbReference type="HOGENOM" id="CLU_142318_0_0_6"/>
    <dbReference type="OMA" id="KWNGEYI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00490">
        <property type="entry name" value="Met_repressor_MetJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00744">
        <property type="entry name" value="MetJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002084">
        <property type="entry name" value="Met_repressor_MetJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023453">
        <property type="entry name" value="Met_repressor_MetJ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01340">
        <property type="entry name" value="MetJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000046497" description="Met repressor">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00744"/>
        </source>
    </evidence>
    <sequence length="105" mass="12141" checksum="05B0F54918C697EF" modified="2005-12-06" version="1">MAEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPDDADLRKERSDEIPEAAKEIMREMGINPETWEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AF7</accession>
    <name>RL10_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplJ</name>
        <name type="ordered locus">SDY_3743</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001207201.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405189.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AF7"/>
    <dbReference type="SMR" id="Q32AF7"/>
    <dbReference type="STRING" id="300267.SDY_3743"/>
    <dbReference type="EnsemblBacteria" id="ABB63698">
        <property type="protein sequence ID" value="ABB63698"/>
        <property type="gene ID" value="SDY_3743"/>
    </dbReference>
    <dbReference type="GeneID" id="67415314"/>
    <dbReference type="KEGG" id="sdy:SDY_3743"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4438"/>
    <dbReference type="HOGENOM" id="CLU_092227_0_2_6"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000234886" description="50S ribosomal protein L10">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <sequence length="165" mass="17712" checksum="F15822B0EDB6AC02" modified="2005-12-06" version="1">MALNLQDKQAIVAEVSEVAKGALSAVVADSRGVTVDKMTELRKAGREAGVYMRVVRNTLLRRAVEGTPFECLKDAFVGPTLIAYSMEHPGAAARLFKEFAKANAKFEVKAAAFEGELIPASQIDRLATLPTYEEAIARLMATMKEASAGKLVRTLAAVRDAKEAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AG3</accession>
    <name>THIG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiazole synthase</fullName>
            <ecNumber evidence="1">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiG</name>
        <name type="ordered locus">SDY_3736</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiG family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63692" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63692.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000944122.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405183.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AG3"/>
    <dbReference type="SMR" id="Q32AG3"/>
    <dbReference type="STRING" id="300267.SDY_3736"/>
    <dbReference type="EnsemblBacteria" id="ABB63692">
        <property type="protein sequence ID" value="ABB63692"/>
        <property type="gene ID" value="SDY_3736"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3736"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4428"/>
    <dbReference type="HOGENOM" id="CLU_062233_1_0_6"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000236365" description="Thiazole synthase">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="256" mass="26906" checksum="341BCC82D019268E" modified="2006-05-30" version="2">MLRIADKTFDSHLVTGTGKFASSQLMVEAIRASGSQLVTLAMKRVDLRQHNDAILEPLIAAGVTLLPNTSGAKTAEEAIFAAHLAREALGTNWLKLEIHPDARWLLPDPIETLKAAETLVQQGFVVLPYCGADPVLCKRLEEVGCAAVMPLGAPIGSNQGLETRAMLEIIIQQATVPVVVDAGIGVPSHAAQALEMGTDAVLVNTAIAVADDPVNMAKAFRLAVEAGLLARQSGPGSRSYFAHATSPLTGFLEASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AI8</accession>
    <name>Q32AI8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yiaI</name>
        <name evidence="5" type="ordered locus">SDY_3706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005019219.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405158.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AI8"/>
    <dbReference type="STRING" id="300267.SDY_3706"/>
    <dbReference type="EnsemblBacteria" id="ABB63667">
        <property type="protein sequence ID" value="ABB63667"/>
        <property type="gene ID" value="SDY_3706"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3706"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4399"/>
    <dbReference type="HOGENOM" id="CLU_043374_3_0_6"/>
    <dbReference type="OMA" id="KACSKRC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB63667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="157" mass="17390" checksum="CF1DD8F00D132B93" modified="2005-12-06" version="1">MNRFIIADATKCIGCRTCEVACAVSHQENQDCAALSPDEFISRIRVIKDHSWATAVACHQCEDAPCANVCPVDAISREHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARAVKCDLCWHRETGPACVEACPTKALQCMDVEKVQRHRLRQQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AN8</accession>
    <name>Q32AN8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glpD</name>
        <name evidence="9" type="ordered locus">SDY_3649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000448119.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405108.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AN8"/>
    <dbReference type="STRING" id="300267.SDY_3649"/>
    <dbReference type="EnsemblBacteria" id="ABB63617">
        <property type="protein sequence ID" value="ABB63617"/>
        <property type="gene ID" value="SDY_3649"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3649"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4331"/>
    <dbReference type="HOGENOM" id="CLU_015740_5_0_6"/>
    <dbReference type="OMA" id="FAYSDCW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="5"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="8">
        <location>
            <begin position="381"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="501" mass="56749" checksum="C439DE3C75093489" modified="2005-12-06" version="1">METKDLIVIGGGINGAGIAADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKMAPHIAFPMRFRLPHRPHLRPAWMIRIGLFMYDHLGKRTSLPGSTGLRFGANSVLKPEIKRGFEYSDCWVDDARLVLANAQMVVRKGGEVLTRTRATSARRENGLWIVEAEDIDTGKKYSWQARGLVNATGPWVKQFFDDGMHLPSPYGIRLIKGSHIVVPRVHTQKQAYILQNEDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLKVYNAHFKKQLSRDDIVWTYSGVRPLCDDESDSPQAITRDYTLDIHDENGKAPLLSVFGGKLTTYRKLAEHALEKLTPYYQDIGPAWTKESVLPGGAIEGDRDDYAARLRRRYPFLTESLARHYARTYGSNSELLLGNAGAISDLGEDFGHEFYEAELKYLVDHEWVRRADDALWRRTKQGMWLNADQQSRVSQWLVEYTQQKLSLAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B33</accession>
    <name>RL23_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplW</name>
        <name type="ordered locus">SDY_3494</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000617536.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404963.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B33"/>
    <dbReference type="SMR" id="Q32B33"/>
    <dbReference type="STRING" id="300267.SDY_3494"/>
    <dbReference type="EnsemblBacteria" id="ABB63472">
        <property type="protein sequence ID" value="ABB63472"/>
        <property type="gene ID" value="SDY_3494"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3494"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4147"/>
    <dbReference type="HOGENOM" id="CLU_037562_3_1_6"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000272845" description="50S ribosomal protein L23">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <sequence length="100" mass="11146" checksum="2BD7ACDCCDCCE9EA" modified="2005-12-06" version="1">MIREECLLKVLRAPHVSEKASTAMEKSNTIVLKVAKDATKAEIKAAVQKLFEVEVEVVNTLVVKGKVKRHGQRIGRRSDWKKAYVTLKEGQNLDFVGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B94</accession>
    <name>Q32B94_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhdRP</name>
        <name evidence="3" type="ordered locus">SDY_3421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001253627.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404902.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B94"/>
    <dbReference type="STRING" id="300267.SDY_3421"/>
    <dbReference type="EnsemblBacteria" id="ABB63411">
        <property type="protein sequence ID" value="ABB63411"/>
        <property type="gene ID" value="SDY_3421"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3421"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4079"/>
    <dbReference type="HOGENOM" id="CLU_003522_0_0_6"/>
    <dbReference type="OMA" id="SLPQSDW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032712">
        <property type="entry name" value="AsmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011836">
        <property type="entry name" value="CHP02099"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025263">
        <property type="entry name" value="DUF3971"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38690">
        <property type="entry name" value="PTHR38690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13502">
        <property type="entry name" value="AsmA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13116">
        <property type="entry name" value="DUF3971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02099">
        <property type="entry name" value="TIGR02099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3971" evidence="1">
        <location>
            <begin position="505"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA_2" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1266" mass="138889" checksum="C664D25A8D6BFEE2" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BA6</accession>
    <name>Q32BA6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yhcB</name>
        <name evidence="4" type="ordered locus">SDY_3409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404890.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BA6"/>
    <dbReference type="STRING" id="300267.SDY_3409"/>
    <dbReference type="EnsemblBacteria" id="ABB63399">
        <property type="protein sequence ID" value="ABB63399"/>
        <property type="gene ID" value="SDY_3409"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3409"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4067"/>
    <dbReference type="HOGENOM" id="CLU_135606_1_0_6"/>
    <dbReference type="OMA" id="HMAKTSS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009386">
        <property type="entry name" value="DUF1043"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39579">
        <property type="entry name" value="PTHR39579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06295">
        <property type="entry name" value="DUF1043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006318">
        <property type="entry name" value="YhcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="134" mass="15221" checksum="9F212867EF4A1072" modified="2005-12-06" version="1">MFMTWEYALIGLVVGIIIGAVAIRFGNRKLRQQQALQYELEKNKAELDEYREELVSHFARSAELLDTMAHDYRQLYQHMAKSSSSLLPELSAEANPFRNRLAESEASNDQAPVQMPRDYSEGASGLLRTGAKRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BC5</accession>
    <name>MTGA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biosynthetic peptidoglycan transglycosylase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycan polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase MtgA</fullName>
            <shortName evidence="1">PGT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtgA</name>
        <name type="ordered locus">SDY_3389</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000047087.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404871.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BC5"/>
    <dbReference type="SMR" id="Q32BC5"/>
    <dbReference type="STRING" id="300267.SDY_3389"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63380">
        <property type="protein sequence ID" value="ABB63380"/>
        <property type="gene ID" value="SDY_3389"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3389"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4043"/>
    <dbReference type="HOGENOM" id="CLU_006354_1_1_6"/>
    <dbReference type="OMA" id="PAPKCFD"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009274">
        <property type="term" value="C:peptidoglycan-based cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00766">
        <property type="entry name" value="PGT_MtgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011812">
        <property type="entry name" value="Pep_trsgly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30400">
        <property type="entry name" value="PTHR30400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02070">
        <property type="entry name" value="mono_pep_trsgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000257693" description="Biosynthetic peptidoglycan transglycosylase">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00766"/>
        </source>
    </evidence>
    <sequence length="242" mass="27326" checksum="9CA541B91BE4BA9F" modified="2005-12-06" version="1">MSKSRLTVFSFVRRFLLRLMVVLAVFWGGGIALFSVAPVPFSAVMVERQVSAWLHGNFRYVAHSDWVSMDQISPWMGLAVIAAEDQKFPEHWGFDVASIEKALAHNERNENRIRGASTISQQTAKNLFLWDGRSWVRKGLEAGLTLGIETVWSKKRILTVYLNIAEFGDGVFGVEAAAQRYFHKPASKLTRSEAALLAAVLPNPLRFKVSAPSGYVRSRQAWILRQMYQLGGEPFMQQHQLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BE4</accession>
    <name>MURA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="1">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murA</name>
        <name type="ordered locus">SDY_3370</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000357268.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404852.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BE4"/>
    <dbReference type="SMR" id="Q32BE4"/>
    <dbReference type="STRING" id="300267.SDY_3370"/>
    <dbReference type="PRIDE" id="Q32BE4"/>
    <dbReference type="EnsemblBacteria" id="ABB63361">
        <property type="protein sequence ID" value="ABB63361"/>
        <property type="gene ID" value="SDY_3370"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3370"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4024"/>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_6"/>
    <dbReference type="OMA" id="CDPHRAT"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000231262" description="UDP-N-acetylglucosamine 1-carboxyvinyltransferase">
        <location>
            <begin position="1"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="120"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <sequence length="419" mass="44862" checksum="B3FEA848455E53F0" modified="2005-12-06" version="1">MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCSATLAEGTTIIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGVNIERVKGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BQ4</accession>
    <name>TTDT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>L-tartrate/succinate antiporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Tartrate carrier</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Tartrate transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ttdT</name>
        <name type="ordered locus">SDY_3247</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the uptake of tartrate in exchange for intracellular succinate. Essential for anaerobic L-tartrate fermentation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000804907.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404742.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BQ4"/>
    <dbReference type="SMR" id="Q32BQ4"/>
    <dbReference type="STRING" id="300267.SDY_3247"/>
    <dbReference type="EnsemblBacteria" id="ABB63251">
        <property type="protein sequence ID" value="ABB63251"/>
        <property type="gene ID" value="SDY_3247"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3247"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3881"/>
    <dbReference type="HOGENOM" id="CLU_005170_7_3_6"/>
    <dbReference type="OMA" id="YAWHFFA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030676">
        <property type="entry name" value="CitT-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42826">
        <property type="entry name" value="PTHR42826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002457">
        <property type="entry name" value="DASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000262716" description="L-tartrate/succinate antiporter">
        <location>
            <begin position="1"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="487" mass="52870" checksum="8E0BE0679AC2BA0D" modified="2005-12-06" version="1">MKPSTEWWRYLAPLAVIAIIALIPVPAGLESHTWLYFAVFTGVIVGLILEPVPGAVVAMVGISIIAILSPWLLFSPEQLAQPGFKFTAKSLSWAVSGFSNSVIWLIFAAFMFGTGYEKNGLGRRIALILVKKMGHRTLFLGYAVMFSELILAPVTPSNSARGAGIIYPIIRNLPPLYQLQPNDSSSRSIGSYIMWIGIVADCVTSAIFLTAMAPNLLLIGLMKSASHATLSWGDWFLGMLPLSILLVLLVPRLAYVLYPPVLKSGDQVPRWAETELQAMGPLCSREKRMLGLMVGALVLWIFGGDYIDAAMVGYSVVALMLLLRIISWDDIVSNKAAWNVFFWLASLITLATGLNNTGFISWFGKLLAGSLSGYSPTMVMVALIVVFYLLRYFFASATAYTSALAPMMIAAALAMPEIPLPVFCLMVGAAIGLGSILTPYATGPSPIYYGSGYLPTADYWRLGAIFGLIFLVLLVITGLLWMPVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BS0</accession>
    <name>Q32BS0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone biosynthesis accessory factor UbiK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiK</name>
        <name evidence="3" type="ordered locus">SDY_3227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404726.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BS0"/>
    <dbReference type="STRING" id="300267.SDY_3227"/>
    <dbReference type="EnsemblBacteria" id="ABB63235">
        <property type="protein sequence ID" value="ABB63235"/>
        <property type="gene ID" value="SDY_3227"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3227"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3853"/>
    <dbReference type="HOGENOM" id="CLU_154412_0_2_6"/>
    <dbReference type="OMA" id="KQPNDVF"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02216">
        <property type="entry name" value="UbiK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007475">
        <property type="entry name" value="UbiK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38040">
        <property type="entry name" value="PTHR38040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04380">
        <property type="entry name" value="BMFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13916" checksum="96342C3897ABE575" modified="2005-12-06" version="1">MTYPYRTTMALNTYQYRETTMIDPKKIEQIARQVHESMPKGIREFGEDVEKKIRQTLQAQLTRLDLVSREEFDVQTQVLLRTREKLALLEQRISELEARNNSIADLQSPPAIPPIDKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BS8</accession>
    <name>Q32BS8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase 4 subunit A</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Topoisomerase IV subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">parC</name>
        <name evidence="8" type="ordered locus">SDY_3218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer composed of ParC and ParE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001281874.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404718.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BS8"/>
    <dbReference type="STRING" id="300267.SDY_3218"/>
    <dbReference type="EnsemblBacteria" id="ABB63227">
        <property type="protein sequence ID" value="ABB63227"/>
        <property type="gene ID" value="SDY_3218"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3218"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3843"/>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_6"/>
    <dbReference type="OMA" id="PRSNRID"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019897">
        <property type="term" value="C:extrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00936">
        <property type="entry name" value="ParC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005742">
        <property type="entry name" value="TopoIV_A_Gneg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="7">
        <location>
            <begin position="8"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="718"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="5">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="5">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="5">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="752" mass="83863" checksum="C9FF54839756D700" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BU7</accession>
    <name>Q32BU7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BU7"/>
    <dbReference type="EnsemblBacteria" id="ABB63208">
        <property type="protein sequence ID" value="ABB63208"/>
        <property type="gene ID" value="SDY_3198"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3198"/>
    <dbReference type="HOGENOM" id="CLU_2221441_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="106" mass="11641" checksum="F3F1B94A3FBBF2D3" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITPFRLSLLSYCLSICSALQAVRLCPGETPDNNVSNAGNNPPQQEQSIQSSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BZ8</accession>
    <name>Q32BZ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS system, mannitol-specific enzyme II component, cryptic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cmtB</name>
        <name evidence="3" type="ordered locus">SDY_3143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001239656.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404648.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BZ8"/>
    <dbReference type="STRING" id="300267.SDY_3143"/>
    <dbReference type="EnsemblBacteria" id="ABB63157">
        <property type="protein sequence ID" value="ABB63157"/>
        <property type="gene ID" value="SDY_3143"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3143"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3754"/>
    <dbReference type="HOGENOM" id="CLU_072531_2_0_6"/>
    <dbReference type="OMA" id="VINDRAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="147" mass="16106" checksum="23D869E60889C485" modified="2005-12-06" version="1">MRLSDYFPESSISVIHSAKDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNSPYYILAPGVAMPHARPECGTLKTGMSLTLLEQGVYFPGNDEPIKLLIGLSAADADSHIGAIQALSELLCEEEILEQLLTASSEKQLADIISRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C64</accession>
    <name>Q32C64_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001059136.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404582.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C64"/>
    <dbReference type="STRING" id="300267.SDY_3075"/>
    <dbReference type="EnsemblBacteria" id="ABB63091">
        <property type="protein sequence ID" value="ABB63091"/>
        <property type="gene ID" value="SDY_3075"/>
    </dbReference>
    <dbReference type="GeneID" id="66673104"/>
    <dbReference type="KEGG" id="sdy:SDY_3075"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3682"/>
    <dbReference type="HOGENOM" id="CLU_156478_0_0_6"/>
    <dbReference type="OMA" id="RYFMAGY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022574">
        <property type="entry name" value="DUF2623"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11115">
        <property type="entry name" value="DUF2623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="95" mass="10945" checksum="3C0BBDF9A5754F8E" modified="2005-12-06" version="1">MNNHFGKGLMAGLKATHADSAVNVTKFCADYKRGFVLGYSHRMYEKTGDRQLSAWEAGILTRRYGLDKEMVMDFFRENNSCSTLRFFMAGYRLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CA4</accession>
    <name>Q32CA4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_3034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.</text>
            <dbReference type="EC" id="3.5.1.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404542.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CA4"/>
    <dbReference type="STRING" id="300267.SDY_3034"/>
    <dbReference type="EnsemblBacteria" id="ABB63051">
        <property type="protein sequence ID" value="ABB63051"/>
        <property type="gene ID" value="SDY_3034"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3034"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3639"/>
    <dbReference type="HOGENOM" id="CLU_014322_2_2_6"/>
    <dbReference type="OMA" id="KRYFAAN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="5">
        <location>
            <begin position="280"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="447" mass="48928" checksum="4E29D7C34909C52B" modified="2005-12-06" version="1">MTDYASFAKVSGQISRLLVTQLRFLLLGRGMSGSNTAISRRRLLQGAGAMWLLSVSQVSLAAVSQVVAVRVWPASSYTRVTVESNRQLKYKQFALGNPERVVVDIEDVNLNSVLKGMAAQIRADDPFIKSARVGQFDPQTVRMVFELKQNVKPQLFALAPVAGFKERLVMDLYPANAQDMQDPLLALLEDYNKGDLEKQVPPAQSGPQPGKAGRDRPIVIMLDPGHGGEDSGAVGKYKTREKDVVLQIARRLRSLIEKEGNMKVYMTRNEDIFIPLQVRVAKAQKQRADLFVSIHADAFTSRQPSGSSVFALSTKGATSTAAKYLAQTQNASDLIGGVSKSGDRYVDHTMFDMVQSLTIADSLKFGKAVLNKLGKINKLHKNQVEQAGFAVLKAPDIPSILVETAFISNVEEERKLKTATFQQEVAESILAGIKAYFADGATLARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CA7</accession>
    <name>Q32CA7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SufE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ygdK</name>
        <name evidence="4" type="ordered locus">SDY_3029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SufE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000184270.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404539.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CA7"/>
    <dbReference type="STRING" id="300267.SDY_3029"/>
    <dbReference type="EnsemblBacteria" id="ABB63048">
        <property type="protein sequence ID" value="ABB63048"/>
        <property type="gene ID" value="SDY_3029"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3029"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3635"/>
    <dbReference type="HOGENOM" id="CLU_124502_1_0_6"/>
    <dbReference type="OMA" id="HYFLADS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017763">
        <property type="entry name" value="Cysteine_desulfurase_CsdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43597">
        <property type="entry name" value="PTHR43597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03391">
        <property type="entry name" value="FeS_syn_CsdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufE" evidence="3">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617763-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="147" mass="15938" checksum="3AECF43C71801C59" modified="2005-12-06" version="1">MTNPQFAGHPFGTTVTAETLRNTFAPLTQWEDKYRQLIMLGKQLPALPDELRAQAKEIAGCENRVWLGYTVAENGKMHFFGDSEGRIVRGLLAVLLTAVEGKTAAELQAQSPLALFDELGLRAQLSASRSQGLNALSEAIIAAAKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CE4</accession>
    <name>Q32CE4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CE4"/>
    <dbReference type="STRING" id="300267.SDY_2988"/>
    <dbReference type="EnsemblBacteria" id="ABB63011">
        <property type="protein sequence ID" value="ABB63011"/>
        <property type="gene ID" value="SDY_2988"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2988"/>
    <dbReference type="HOGENOM" id="CLU_027402_21_2_6"/>
    <dbReference type="OMA" id="HEITVIY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="132" mass="15518" checksum="8BD5E610DFFF8561" modified="2005-12-06" version="1">MCQVFGVSRSGYYNWVQHKPSDRKQSDERLKLEIKVAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWGADLTYVATQEGWFEVYWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CL4</accession>
    <name>Q32CL4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ascB</name>
        <name evidence="6" type="ordered locus">SDY_2912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378845.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404432.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CL4"/>
    <dbReference type="STRING" id="300267.SDY_2912"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62941">
        <property type="protein sequence ID" value="ABB62941"/>
        <property type="gene ID" value="SDY_2912"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2912"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3497"/>
    <dbReference type="HOGENOM" id="CLU_001859_0_2_6"/>
    <dbReference type="OMA" id="FEEGYFY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="474" mass="53786" checksum="A6572D302DCABCC8" modified="2005-12-06" version="1">MSVFPQGFLWGGALAANQSEGAFREGGKGLTTVDMIPHGKHRMAVKLGLEKRFQLRDDEFYPSHEATDFYHRYKEDIALMAEMGFKVFRTSIAWSRLFPQGDELTPNQQGIAFYRSVFKECKKYGIEPLVTLCHFDVPMHLVTEYGSWRNRKLVEFFSRYARTCFEAFDGLVKYWLTFNEINIMLHSPFSGAGLVFEEGENQDQVKYQAAHHQLVASALATKIAHEVNPQNQVGCMLAGGNFYPYSCKPEDVWAALEKDRENLFFINVQARGAYPAYSARVFREKGVTINKAPGDDEILKNTVDFVSFSYYASRCASAEMNANNSSAANVVKSLRNPYLQVSDWGWGIDPLGLRITMNMMYDRYQKPLFLVENGLGAKDEFAASGEINDDYRISYLREHIRAMGEAIADGIPLMGYTTWGCIDLVSASTGEMSKRYGFVFVDRDDAGNGTLTRTRKKSFWWYKKVIASNGEDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CN8</accession>
    <name>Q32CN8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA_ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001097134.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404408.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CN8"/>
    <dbReference type="STRING" id="300267.SDY_2882"/>
    <dbReference type="EnsemblBacteria" id="ABB62917">
        <property type="protein sequence ID" value="ABB62917"/>
        <property type="gene ID" value="SDY_2882"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2882"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3466"/>
    <dbReference type="HOGENOM" id="CLU_080123_1_0_6"/>
    <dbReference type="OMA" id="QSETHWM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_ligase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="235" mass="27726" checksum="EDFD514B75583A16" modified="2005-12-06" version="1">MNTQRKYGRTWHYPFSPSTTSDDRINADYWQDLQAITQLVHTEKLDGENNCLNRYGVFARSHAAPTQPAWTYKIRQRWQLLKNDLGDLELFGENIYAVHSIEYRALEQDFYLFAVRCQDMWLSWEEVQFYAALFDFPCVPEISGPQPGNDEKSWQRDFLALTNARGAFDPWDTQTGQPCTLEGIVSRNRDAFSVADFSHNVFKYVRKNHVKTTVHWKRHWQRARMAHEFAYGEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CT3</accession>
    <name>Q32CT3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfiM</name>
        <name evidence="1" type="ordered locus">SDY_2829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404363.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CT3"/>
    <dbReference type="STRING" id="300267.SDY_2829"/>
    <dbReference type="EnsemblBacteria" id="ABB62872">
        <property type="protein sequence ID" value="ABB62872"/>
        <property type="gene ID" value="SDY_2829"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2829"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3406"/>
    <dbReference type="HOGENOM" id="CLU_155273_0_0_6"/>
    <dbReference type="OMA" id="YAVWQMA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018736">
        <property type="entry name" value="DUF2279_periplasmic_lipo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017028">
        <property type="entry name" value="UCP034456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10043">
        <property type="entry name" value="DUF2279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034456">
        <property type="entry name" value="UCP034456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="98" mass="10742" checksum="A752206C87AB929A" modified="2005-12-06" version="1">MLLSGCSHIANDSWSGQDKAQHFIASAMLSAAGNEYSQHQGMSRDRSAMFGLMFSVSLGASKELWDSRPEGSGWSWKDLAWDVAGASTGYTVWQLTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D19</accession>
    <name>Q32D19_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein P-II for glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnB</name>
        <name evidence="5" type="ordered locus">SDY_2743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the P(II) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000717694.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404277.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D19"/>
    <dbReference type="SMR" id="Q32D19"/>
    <dbReference type="STRING" id="300267.SDY_2743"/>
    <dbReference type="EnsemblBacteria" id="ABB62786">
        <property type="protein sequence ID" value="ABB62786"/>
        <property type="gene ID" value="SDY_2743"/>
    </dbReference>
    <dbReference type="GeneID" id="63941229"/>
    <dbReference type="GeneID" id="67416931"/>
    <dbReference type="KEGG" id="sdy:SDY_2743"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3308"/>
    <dbReference type="HOGENOM" id="CLU_082268_0_0_6"/>
    <dbReference type="OMA" id="HQIEVNF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="12425" checksum="D1A4158A2F225042" modified="2005-12-06" version="1">MKKIDAIIKPFKLDDVREALAEVGITGMTVTEVKGFGRQKGHTELYRGAEYMVDFLPKVKIEIVVPDDIVDTCVDTIIRTAQTGKIGDGKIFVFDVARVIRIRTGEEDDAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D34</accession>
    <name>Q32D34_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cysteine desulfurase IscS</fullName>
            <ecNumber evidence="10">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yfhO</name>
        <name evidence="10" type="synonym">iscS</name>
        <name evidence="13" type="ordered locus">SDY_2726</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404262.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D34"/>
    <dbReference type="STRING" id="300267.SDY_2726"/>
    <dbReference type="EnsemblBacteria" id="ABB62771">
        <property type="protein sequence ID" value="ABB62771"/>
        <property type="gene ID" value="SDY_2726"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2726"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3288"/>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_6"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="12">
        <location>
            <begin position="13"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="10">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="10">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="10">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared with IscU</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB62771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="412" mass="46062" checksum="F433DB8B2F07F662" modified="2005-12-06" version="1">MMYGVYRAMKLPIYLDYSATTPVDPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIADLVGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIAAIGEMCRARGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRVRIEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMERLRGLRNRLWNGIKDIEEVYLNGDLEHGAPNILNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFSLGRFTTEEEIDYTIELVRKSIGRLRDLSPLWEMYKQGVDLNSIEWAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D60</accession>
    <name>Q32D60_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404236.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D60"/>
    <dbReference type="STRING" id="300267.SDY_2698"/>
    <dbReference type="EnsemblBacteria" id="ABB62745">
        <property type="protein sequence ID" value="ABB62745"/>
        <property type="gene ID" value="SDY_2698"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2698"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3256"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15394" checksum="0FC5293C5751327E" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWSSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D74</accession>
    <name>Q32D74_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-barrel assembly-enhancing protease</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bepA</name>
        <name evidence="11" type="ordered locus">SDY_2683</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M48 family. BepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000489648.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404222.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D74"/>
    <dbReference type="STRING" id="300267.SDY_2683"/>
    <dbReference type="MEROPS" id="M48.023"/>
    <dbReference type="EnsemblBacteria" id="ABB62731">
        <property type="protein sequence ID" value="ABB62731"/>
        <property type="gene ID" value="SDY_2683"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2683"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3237"/>
    <dbReference type="HOGENOM" id="CLU_030556_0_1_6"/>
    <dbReference type="OMA" id="HLSQRHF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00997">
        <property type="entry name" value="Protease_BepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030873">
        <property type="entry name" value="Protease_BepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0574">Periplasm</keyword>
    <keyword evidence="1 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019121" description="Beta-barrel assembly-enhancing protease" evidence="9">
        <location>
            <begin position="28"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="10">
        <location>
            <begin position="72"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="487" mass="53893" checksum="B3FCE73E3536F46A" modified="2005-12-06" version="1" precursor="true">MFRQLKKNLVATLIAAMTIGQVAPAFADSADTLPDMGTSAGSTLSIGQEMQMGDYYVRQLRGSAPLINDPLLTQYINSLGMRLVSHANSVKTPFHFFLINNDEINAFAFFGGNVVLHSALFRYSDNESQLASVMAHEISHVTQRHLAQAMEDQQRSAPLTWVGALGSILLAMASPQAGMAALTGTLAGTRQGMISFTQQNEQEADRIGIQVLQRSGFDPQAMPTFLEKLLDQARYSSRPPEILLTHPLPESRLADARNRANQMRPMVVQSSEDFYLAKARTLGMHNSGRNHLTSDLLDEWAKGNVRQQRAAQYGRALQAMEANKYDEARKTLQPLLAAEPSNAWYLDLATDIDLGQNKANEAINRLKNARDLRTNPVLQLNLANAYLQGGQPQEAANILNRYTFNNKDDSNGWDLLAQAEAALNNRDQELAARAEGYALAGRLDQAISLLSSASSQVKLGSLQQARYDARIDQLRQLQERFKPYTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D93</accession>
    <name>Q32D93_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA(Met) cytidine acetyltransferase TmcA</fullName>
            <ecNumber evidence="9">2.3.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ypfI</name>
        <name evidence="9" type="synonym">tmcA</name>
        <name evidence="11" type="ordered locus">SDY_2661</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43788"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TmcA family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.193" evidence="9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000829296.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404203.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D93"/>
    <dbReference type="STRING" id="300267.SDY_2661"/>
    <dbReference type="EnsemblBacteria" id="ABB62712">
        <property type="protein sequence ID" value="ABB62712"/>
        <property type="gene ID" value="SDY_2661"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2661"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3212"/>
    <dbReference type="HOGENOM" id="CLU_004652_1_1_6"/>
    <dbReference type="OMA" id="NEPDDLG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01886">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="Helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DUF1726"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_RecD"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="356"/>
            <end position="531"/>
        </location>
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            <begin position="461"/>
            <end position="463"/>
        </location>
    </feature>
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            <begin position="468"/>
            <end position="474"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01886"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="671" mass="74786" checksum="0653EADA7879357B" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
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    <name>Q32DF9_SHIDS</name>
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            <fullName evidence="11">Putative transport protein</fullName>
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    </protein>
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        <lineage>
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            <taxon>Enterobacteriaceae</taxon>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
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            <end position="68"/>
        </location>
    </feature>
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            <end position="119"/>
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            <end position="219"/>
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            <end position="256"/>
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            <end position="335"/>
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            <end position="361"/>
        </location>
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        <location>
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            <end position="402"/>
        </location>
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    </evidence>
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    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABB62646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="415" mass="43925" checksum="0CD36FFF2102EA48" modified="2005-12-06" version="1">MAIKKRSATVVPGASGAAAAVKNPQASKSSFWGELPQHVMSGISRMVPTLIMGGVILAFSKLIAYSWLKIPADIGIMDALNSGKFSGFDLSLLKFAWLSQSFGGVLFGFAIPIFAAFVANSIGGKLAFPAGFIGGLMSTQPTQLLNFDPSTMQWATSSPVPSTFIGALIISIVAGYLVKWMNQKIQLLDFLLAYKTTFLLPILSAIFVMLAMYYVITPFGGWINGGIRTVLTAAGEKGALMYAMGIAAATAIDLGGPINKAAGFVAFSFTTDHVLPVTARSIAIVIPPIGLGLATIIDRRLTGKRLFSAQLYPQGKTAMFLAFMGISEGAIPFALESPITAIPSYMVGAIVGSTAAVWLGAVQWFPESAIWAWPLVTNLGVYMAGIALGAVITALMVVFLRLMMFRKGKLLIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DN0</accession>
    <name>Q32DN0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding component of histidine transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisP</name>
        <name evidence="8" type="ordered locus">SDY_2505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404066.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
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    <dbReference type="STRING" id="300267.SDY_2505"/>
    <dbReference type="EnsemblBacteria" id="ABB62575">
        <property type="protein sequence ID" value="ABB62575"/>
        <property type="gene ID" value="SDY_2505"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2505"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3020"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_6"/>
    <dbReference type="OMA" id="EVFCLIG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="257" mass="28611" checksum="F22F598F2EAE0293" modified="2005-12-06" version="1">MSENKLNVIDLHKRYGEHEVLKGVSLQANAGDVISIIGSSGSGKSTFLRCINFLEKPSEGSIVVNGQTINLVRDKDGQLKVADKNQLRLLRTRLTMVFQHFNLWSHMTVLENVMEAPIQVLGLSKQEARERAVKYLAKVGIDERAQGKYPVHLSGGQQQRVSIARALAMEPEVLLFDEPTSALDPELVGEVLRIMQQLAEEGKTMVVVTHEMGFARHVSTHVIFLHQGKIEEEGAPDQLFGNPQSPRLQQFLKGSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DP0</accession>
    <name>Q32DP0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Uncharacterized Nudix hydrolase YfcD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_2495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000401194.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404056.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DP0"/>
    <dbReference type="STRING" id="300267.SDY_2495"/>
    <dbReference type="EnsemblBacteria" id="ABB62565">
        <property type="protein sequence ID" value="ABB62565"/>
        <property type="gene ID" value="SDY_2495"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2495"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3007"/>
    <dbReference type="HOGENOM" id="CLU_060552_3_0_6"/>
    <dbReference type="OMA" id="PGYWDVA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024195">
        <property type="entry name" value="NUDIX_hydrolase_YfcD_pred"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017340">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017340-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="180" mass="20385" checksum="4AF6150B52A61D68" modified="2005-12-06" version="1">MEHRRLASTEWVDIVNEENEVIAQASREQMRAQCLRHRATYIVVHDGMGKILVQRRTETKDFLPGMLDATAGGVVQADEQLLESARREAEEELGIAGVPFAEHGQFYFEDKNCRVWGALFSCVSHGPFALQEDEVSEVCWLTPEEITARCDEFTPDSLKALALWMKRNAKNEAVETETAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EE3</accession>
    <name>Q32EE3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EE3"/>
    <dbReference type="EnsemblBacteria" id="ABB62312">
        <property type="protein sequence ID" value="ABB62312"/>
        <property type="gene ID" value="SDY_2228"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2228"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="HIDISYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32020" checksum="D1FA46CF86AF4B02" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSSREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EH1</accession>
    <name>Q32EH1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000687871.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403775.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EH1"/>
    <dbReference type="EnsemblBacteria" id="ABB62284">
        <property type="protein sequence ID" value="ABB62284"/>
        <property type="gene ID" value="SDY_2199"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2199"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2659"/>
    <dbReference type="HOGENOM" id="CLU_163934_2_2_6"/>
    <dbReference type="OMA" id="FSSVWDA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="96" mass="10790" checksum="705666540EA8099C" modified="2005-12-06" version="1">MKIETFDSVWDAVSDTPEQAENMRIRAELVTIINNWIEQQGFSQAQAASALGVTQPRISELARGKIQIFSIDKLITMMAHAGLHIQRIEIQYPHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EK4</accession>
    <name>Q32EK4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yehS</name>
        <name evidence="2" type="ordered locus">SDY_2165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295430.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403742.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EK4"/>
    <dbReference type="STRING" id="300267.SDY_2165"/>
    <dbReference type="EnsemblBacteria" id="ABB62251">
        <property type="protein sequence ID" value="ABB62251"/>
        <property type="gene ID" value="SDY_2165"/>
    </dbReference>
    <dbReference type="GeneID" id="66673981"/>
    <dbReference type="KEGG" id="sdy:SDY_2165"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2617"/>
    <dbReference type="HOGENOM" id="CLU_087517_1_0_6"/>
    <dbReference type="OMA" id="KEDDMHA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009921">
        <property type="entry name" value="DUF1456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07308">
        <property type="entry name" value="DUF1456"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1456" evidence="1">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1456" evidence="1">
        <location>
            <begin position="86"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="156" mass="18003" checksum="485AEB1A434A1A5A" modified="2005-12-06" version="1">MLSNDILRSVRYILKANNNDLVRILALGNVEATAEQIAVWLRKEDEEGFQRCPDIVLSSFLNGLIYEKRGKDESAPALEPERRINNNIVLKKLRIAFSLKTDDILAILTEQQFRVSMPEITAMMRAPDHKNFRECGDQFLRYFLRGLAARQHVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EL7</accession>
    <name>Q32EL7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative channel/filament proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yohG</name>
        <name evidence="3" type="ordered locus">SDY_2150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EL7"/>
    <dbReference type="STRING" id="300267.SDY_2150"/>
    <dbReference type="EnsemblBacteria" id="ABB62238">
        <property type="protein sequence ID" value="ABB62238"/>
        <property type="gene ID" value="SDY_2150"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2150"/>
    <dbReference type="HOGENOM" id="CLU_012817_6_0_6"/>
    <dbReference type="OMA" id="ARFRHWR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="306" mass="33916" checksum="7C110219CABB4985" modified="2005-12-06" version="1">MSAEGLMGPFALNDPAAGTTGPWYTNGTFGLTAGWHLDIWGKNRAEVTARLGTVKARAAEREQTRQLLAGSVARLYWEWQTQAALNTVLQQIEKEQNTIIATDRQLYQNGITSSVEGVETDINASKTRQQLNDVAGEMKIIEARLNALTNHQTKSLKLKPVTLPKVASQLPDELGYSLLARRADLQAAHWYVESSLSTIDAAKAAFYPDINLMAFLQQDALHLSDLFRHSAQQMGVTAGLTLPIFDSGRLNANLDIAKAESNLSIASYNKAVVEAVNDVRGRPARFRHWRRKTSIRRKLSTMPCVW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ES3</accession>
    <name>PYRC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroorotase</fullName>
            <shortName evidence="1">DHOase</shortName>
            <ecNumber evidence="1">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrC</name>
        <name type="ordered locus">SDY_2091</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000126536.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403673.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ES3"/>
    <dbReference type="SMR" id="Q32ES3"/>
    <dbReference type="STRING" id="300267.SDY_2091"/>
    <dbReference type="EnsemblBacteria" id="ABB62182">
        <property type="protein sequence ID" value="ABB62182"/>
        <property type="gene ID" value="SDY_2091"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2091"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2516"/>
    <dbReference type="HOGENOM" id="CLU_041558_1_0_6"/>
    <dbReference type="OMA" id="TLHHISM"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="PTHR43137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000024060" description="Dihydroorotase">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00219"/>
        </source>
    </evidence>
    <sequence length="348" mass="38800" checksum="0254DF02421E9238" modified="2005-12-06" version="1">MTAPSQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANATTNSSHGVTSIDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFSAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ET8</accession>
    <name>Q32ET8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar hook protein FlgE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">flgE</name>
        <name evidence="9" type="ordered locus">SDY_2075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000885869.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403658.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ET8"/>
    <dbReference type="STRING" id="300267.SDY_2075"/>
    <dbReference type="EnsemblBacteria" id="ABB62167">
        <property type="protein sequence ID" value="ABB62167"/>
        <property type="gene ID" value="SDY_2075"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2075"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2493"/>
    <dbReference type="HOGENOM" id="CLU_013687_2_0_6"/>
    <dbReference type="OMA" id="GLQNHQT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011491">
        <property type="entry name" value="Falgellar_hook_FlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037058">
        <property type="entry name" value="Falgellar_hook_FlgE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07559">
        <property type="entry name" value="FlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="FlaE" evidence="8">
        <location>
            <begin position="173"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="324"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="402" mass="41998" checksum="FCB0BB0A6B7F3C21" modified="2005-12-06" version="1">MAFSQAVSGLNAAATNLDVIGNNIANSATYGFKSGTASFADMFAGSKVGLGVKVAGITQDFTDGTTTNTGRGLDVAISQNGFFRLVDSNGSVFYSRNGQFKLDENRNLVNMQGLQLTGYPATGTPPTIQQGANPTNISIPNTLMAAKTTTTASMQINLNSSDPLPTVTPFSASNADSYNKKGSVTVFDSQGNAHDMSVYFVKTGDNNWQVYTQDSSDPNSIAKAATTLKFNANGTLVDGAMANNIATGAINGAEPATFSLSFPNSMQQNTGANNIVATTQNGYKPGDLVSYQINDDGTVVGNYSNEQTQLLGQIVLANFANNEGLASEGDNVWSATQSSGVALLGTAGTGNFGTLTNGALEASNVDLSKELVNMIVAQRNYQSNAQTIKTQDQILNTLVNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EU5</accession>
    <name>Q32EU5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yceC</name>
        <name evidence="6" type="ordered locus">SDY_2065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000846354.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403651.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EU5"/>
    <dbReference type="STRING" id="300267.SDY_2065"/>
    <dbReference type="EnsemblBacteria" id="ABB62160">
        <property type="protein sequence ID" value="ABB62160"/>
        <property type="gene ID" value="SDY_2065"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2065"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2481"/>
    <dbReference type="HOGENOM" id="CLU_016902_1_1_6"/>
    <dbReference type="OMA" id="PKTHVYR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="319" mass="36053" checksum="039771F458CEA25E" modified="2005-12-06" version="1">MKTETPSVKIVAITADEAGQRIDNFLRTQLKGVPKSMIYRILRKGEVRVNKKRIKPEYKLEAGDEVRIPPVRVAEREEEAVSPHLQKVAALADVILYEDDYILVLNKPSGTAVHGGSGLSFGVIEGLRALRPEARFLELVHRLDRDTSGVLLVAKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKSVQAPLLKNILQSGERIVRVSQEGKPSETRFKVEERYAFATLVRCSPVTGRTHQIRVHTQYAGHPIAFDDRYGDREFDRQLTEAGTGLNRLFLHAAALKFTHPGTGEVMRIEAPMDEGLKRCLQKLRNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EV2</accession>
    <name>Q32EV2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3 6">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fabD</name>
        <name evidence="9" type="ordered locus">SDY_2058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3 6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000191396.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403644.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EV2"/>
    <dbReference type="STRING" id="300267.SDY_2058"/>
    <dbReference type="EnsemblBacteria" id="ABB62153">
        <property type="protein sequence ID" value="ABB62153"/>
        <property type="gene ID" value="SDY_2058"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2058"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2473"/>
    <dbReference type="HOGENOM" id="CLU_030558_0_0_6"/>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="8">
        <location>
            <begin position="7"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="309" mass="32419" checksum="AB77DDAEE68D0A69" modified="2005-12-06" version="1">MTQFAFVFPGQGSQTVGMLTDMAASYPIVEETFAEASAALGYDLWALTQQGPAEELNKTWQTQPALLTASVALYCVWQQQGGKAPALMAGHSQGEYSALVCAGVIDFADAVRLVEMRGKFMQEAVPEGTGAMAAIIGLDDASIAKACEEAAEGQVVSPVNFNSPGQVVIAGHKEAVERAGAACKAAGAKRALPLPVSVPSHCALMKPAADKLAVELAKITFNAPTVPVVNNVDVKCETNGDAIRDALVRQLYNPVQWTKSVEYMAARGVEHLYEVGPGKVLTGLTKRIVDTLTASALNEPSAMAAALEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EX0</accession>
    <name>Q32EX0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rick_17kDa_Anti domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycfJ</name>
        <name evidence="2" type="ordered locus">SDY_2040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001043459.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403626.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EX0"/>
    <dbReference type="STRING" id="300267.SDY_2040"/>
    <dbReference type="EnsemblBacteria" id="ABB62135">
        <property type="protein sequence ID" value="ABB62135"/>
        <property type="gene ID" value="SDY_2040"/>
    </dbReference>
    <dbReference type="GeneID" id="66670624"/>
    <dbReference type="KEGG" id="sdy:SDY_2040"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2454"/>
    <dbReference type="HOGENOM" id="CLU_094245_1_0_6"/>
    <dbReference type="OMA" id="PREVCKD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rick_17kDa_Anti" evidence="1">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="179" mass="18920" checksum="BA5EB0DB56D45609" modified="2005-12-06" version="1">MNKSMLAGIGIGVAAALGVAAVASLNVFERGPQYAQVVSATPIKETVKTPRQECRNVTVTHRRPVQDENRITGSVLGAVAGGVIGHQFGGGRGKDVATVVGALGGGYAGNQIQGSLQESDTYTTTQQRCKTVYDKSEKMLGYDVTYKIGDQQGKIRMDRDPGTQIPLDSNGQLILNNKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EY5</accession>
    <name>PEPT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase T</fullName>
            <ecNumber evidence="1">3.4.11.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aminotripeptidase</fullName>
            <shortName evidence="1">Tripeptidase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tripeptide aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pepT</name>
        <name type="ordered locus">SDY_2025</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the N-terminal amino acid of tripeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of the N-terminal residue from a tripeptide.</text>
            <dbReference type="EC" id="3.4.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000359446.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403611.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EY5"/>
    <dbReference type="SMR" id="Q32EY5"/>
    <dbReference type="STRING" id="300267.SDY_2025"/>
    <dbReference type="MEROPS" id="M20.003"/>
    <dbReference type="EnsemblBacteria" id="ABB62120">
        <property type="protein sequence ID" value="ABB62120"/>
        <property type="gene ID" value="SDY_2025"/>
    </dbReference>
    <dbReference type="GeneID" id="58461245"/>
    <dbReference type="KEGG" id="sdy:SDY_2025"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2438"/>
    <dbReference type="HOGENOM" id="CLU_053676_0_0_6"/>
    <dbReference type="OMA" id="GHNFHGK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00550">
        <property type="entry name" value="Aminopeptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PTHR42994:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000274019" description="Peptidase T">
        <location>
            <begin position="1"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00550"/>
        </source>
    </evidence>
    <sequence length="408" mass="44909" checksum="35744B1DF4CC1DA2" modified="2005-12-06" version="1">MDKLLERFLNYVSLDTQSKAGVRQVPSTEGQWKLLHLLKEQLEEMGLINVTLSEKGTLMATLPANVPGDIPAIGFISHVDTSPDCSGKNVNPQIVENYRGGDIALGIGDEVLSPVMFPVLHQLLGQTLITTDGKTLLGADDKAGIAEIMTALAVLQQKNIPHGDIRVAFTPDEEVGKGAKHFDVDAFDARWAYTVDGGGVGELEFENFNAASVNIKIVGNNVHPGTAKGVMVNALSLAARIHAEVPADESPEMTEGYEGFYHLASMKGTVERADMHYIIRDFDRKQFEARKRKMMEIAKKVGKGLHPDCYIELVIEDSYYNMREKVVEHPHILDIAQQAMRDCDIEPELKPIRGGTDGAQLSFMGLPCPNLFTGGYNYHGKHEFVTLEGMEKAVQVIVRIAELTAQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F05</accession>
    <name>Q32F05_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS600 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F05"/>
    <dbReference type="EnsemblBacteria" id="ABB62100">
        <property type="protein sequence ID" value="ABB62100"/>
        <property type="gene ID" value="SDY_2005"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2005"/>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="83" mass="9228" checksum="A7209AE4598C5110" modified="2005-12-06" version="1">MSRKTQRYSKEFKAEAVRTVLENQLSISEGASRLSLPEGTLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F36</accession>
    <name>Q32F36_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspC</name>
        <name evidence="4" type="ordered locus">SDY_1969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001062678.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403560.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F36"/>
    <dbReference type="SMR" id="Q32F36"/>
    <dbReference type="STRING" id="300267.SDY_1969"/>
    <dbReference type="EnsemblBacteria" id="ABB62069">
        <property type="protein sequence ID" value="ABB62069"/>
        <property type="gene ID" value="SDY_1969"/>
    </dbReference>
    <dbReference type="GeneID" id="8911702"/>
    <dbReference type="KEGG" id="sdy:SDY_1969"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2377"/>
    <dbReference type="HOGENOM" id="CLU_117621_2_1_6"/>
    <dbReference type="OMA" id="FEIQDGH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="7402" checksum="2A644A4C96F4B425" modified="2005-12-06" version="1">MAKIKGQVKWFNESKGFGFITPADGSKDVFVHFSAIQGNGFKTLAEGQNVEFEIQDGQKGPAAVNVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F42</accession>
    <name>Q32F42_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yoaE</name>
        <name evidence="7" type="ordered locus">SDY_1962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0053 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000395004.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403554.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F42"/>
    <dbReference type="STRING" id="300267.SDY_1962"/>
    <dbReference type="EnsemblBacteria" id="ABB62063">
        <property type="protein sequence ID" value="ABB62063"/>
        <property type="gene ID" value="SDY_1962"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1962"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2369"/>
    <dbReference type="HOGENOM" id="CLU_015237_0_1_6"/>
    <dbReference type="OMA" id="MRFINRH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="302"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="516" mass="56320" checksum="DDDBA018818C3238" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F73</accession>
    <name>Q32F73_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000939561.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403523.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F73"/>
    <dbReference type="STRING" id="300267.SDY_1926"/>
    <dbReference type="REBASE" id="11595">
        <property type="entry name" value="M.SdySORF1926P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62032">
        <property type="protein sequence ID" value="ABB62032"/>
        <property type="gene ID" value="SDY_1926"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1926"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2322"/>
    <dbReference type="HOGENOM" id="CLU_025185_0_0_6"/>
    <dbReference type="OMA" id="TIFTEDK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011639">
        <property type="entry name" value="RM_methylase_Eco57I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07669">
        <property type="entry name" value="Eco57I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eco57I" evidence="4">
        <location>
            <begin position="134"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="489" mass="54968" checksum="F108E47DD82FE6C7" modified="2005-12-06" version="1">MLQKLDVADSVRRELSPRTARKHKAEFGQFMTPSGVARFMASLFPPSTMKTCRLLDAGAGVGALSCAFLDRWLVGEFGFESVEATAYEIDKKLCGHLAKHLTGYRRVTPRIIEGDYIELATAEGLQYRGYTHAILNPPYKKINSQSAHRQALRAVGIETVNLYSAFVALAVGEVAPGGQIVAIIPRSFCNGPYYRPFRNFILERAAIRHIHLFESRSKAFRDDDVLQENIIIRLERGGRQEAVTVTTSTDDSFFDLVTYEHPFDQIVYPDDSERFIHVPTTLEKSAIELSSAVQCSLADIGVKVSTGPIVDFRLKAHLRSMPEEGTVPLIYPSHLSMSSTVWPVEGLKKPNAIMRNDETEKWLYPNGFYCVVRRFSSKEEKRRVVASVVDPATFSEYSVLGFENHMNVFHENKHGLPEALARGLAVFLNTTAVDKYFRRFNGHTQVNATDLKMIKYPSRDTLIELGKWAMQQETLTQEHIDAKLGALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F75</accession>
    <name>Q32F75_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001240876.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403521.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F75"/>
    <dbReference type="EnsemblBacteria" id="ABB62030">
        <property type="protein sequence ID" value="ABB62030"/>
        <property type="gene ID" value="SDY_1924"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1924"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2320"/>
    <dbReference type="HOGENOM" id="CLU_199069_0_0_6"/>
    <dbReference type="OMA" id="AEECRPF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000655">
        <property type="entry name" value="Cro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038202">
        <property type="entry name" value="Cro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09048">
        <property type="entry name" value="Cro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003217">
        <property type="entry name" value="Cro_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7477" checksum="AC9E41DF3E0FB41B" modified="2005-12-06" version="1">MAMKKETLADYVYRFGQKKAAKDFGVAQSAISKALLVGREIYVKTFDDGTVEAEEVRPFPAFVRGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F83</accession>
    <name>Q32F83_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative DNA-invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_1916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000905066.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403513.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F83"/>
    <dbReference type="SMR" id="Q32F83"/>
    <dbReference type="STRING" id="300267.SDY_1916"/>
    <dbReference type="EnsemblBacteria" id="ABB62022">
        <property type="protein sequence ID" value="ABB62022"/>
        <property type="gene ID" value="SDY_1916"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1916"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2307"/>
    <dbReference type="HOGENOM" id="CLU_010686_8_0_6"/>
    <dbReference type="OMA" id="INRHEQE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5 6">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="197" mass="22309" checksum="204F4FF666FD5C1C" modified="2005-12-06" version="1">MLIGYVRVSTNDQNTDLQRNALVCAGCEQIFEDKLSGTRTDRPGLKRALKRLQKGDTLVVWKLDRLGRSMKHLISLVGELRERGINFRSLTDSIDTSSPMGRFFFHVMGALAEMERELIIERTMAGLAAARNKGRIGGRPPKLTKAEWEQAGRLLAQGIPRKQVALIYDVALSTLYKKHPAKRTHIENDDRINQIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FB4</accession>
    <name>Q32FB4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_1883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000701040.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403482.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FB4"/>
    <dbReference type="SMR" id="Q32FB4"/>
    <dbReference type="STRING" id="300267.SDY_1883"/>
    <dbReference type="EnsemblBacteria" id="ABB61991">
        <property type="protein sequence ID" value="ABB61991"/>
        <property type="gene ID" value="SDY_1883"/>
    </dbReference>
    <dbReference type="GeneID" id="66674451"/>
    <dbReference type="KEGG" id="sdy:SDY_1883"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2265"/>
    <dbReference type="HOGENOM" id="CLU_001265_61_2_6"/>
    <dbReference type="OMA" id="EFAPMGL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="6"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="389" mass="40064" checksum="90A6A22CBD565BF3" modified="2005-12-06" version="1">MKINYPLLALAIGAFGIGTTEFSPMGLLPVIARGVDVSIPAAGMLISAYAVGVMVGAPLMTLLLSHRARRSALIFLMAIFTLGNVLSAIAPDYMTLMLSRILTSLNHGAFFGLGSVVAASVVPKHKQASAVATMFMGLTLANIGGVPAATWLGETIGWRMSFLATAGLGVISMVSLFFSLPKGGAGARPEVKKELAVLMRPQVLSALLTTVLGAGAMFTLYTYISPVLQSITHATPVFVTAMLVLIGVGFSIGNYLGGKLADRSVNGTLKGFLLLLMVIMLAIPFLARNEFGAAISMVVWGAATFAVVPPLQMRVMRVASEAPGLSSSVNIGAFNLGNALGAAAGGAVISAGLGYSFVPVMGAIVAGLALLLVFMSARKQPETVCVANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FB5</accession>
    <name>Q32FB5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Superoxide dismutase</fullName>
            <ecNumber evidence="5 9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sodB</name>
        <name evidence="12" type="ordered locus">SDY_1882</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="5 9"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000007283.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403481.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FB5"/>
    <dbReference type="SMR" id="Q32FB5"/>
    <dbReference type="STRING" id="300267.SDY_1882"/>
    <dbReference type="EnsemblBacteria" id="ABB61990">
        <property type="protein sequence ID" value="ABB61990"/>
        <property type="gene ID" value="SDY_1882"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1882"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2264"/>
    <dbReference type="HOGENOM" id="CLU_031625_0_0_6"/>
    <dbReference type="OMA" id="YLHSIFW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="11">
        <location>
            <begin position="89"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB61990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="193" mass="21266" checksum="91236D2A8FE61474" modified="2005-12-06" version="1">MSFELPALPYAKDALAPHISAETIEYHYGKHHQTYVTNLNNLIKGTAFEGKSLEEIIRSSEGGVFNNAAQVWNHTFYWNCLAPNAGGEPTGKVAEAIAASFGSFADFKAQFTDAAIKNFGSGWTWLVKNSDGKLAIVSTSNAGTPLTTDATPLLTVDVWEHAYYIDYRNARPGYLEHFWALVNWEFVAKNLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FD8</accession>
    <name>Q32FD8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathionine S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gst</name>
        <name evidence="4" type="ordered locus">SDY_1858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000765749.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403458.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FD8"/>
    <dbReference type="SMR" id="Q32FD8"/>
    <dbReference type="STRING" id="300267.SDY_1858"/>
    <dbReference type="EnsemblBacteria" id="ABB61967">
        <property type="protein sequence ID" value="ABB61967"/>
        <property type="gene ID" value="SDY_1858"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1858"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2237"/>
    <dbReference type="HOGENOM" id="CLU_011226_6_1_6"/>
    <dbReference type="OMA" id="YVATELH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="87"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="201" mass="22868" checksum="6347401123B044E2" modified="2005-12-06" version="1">MKLFYKPGACSLASHITLRESGKDFTLVSVDLMKKRLENGDDYFAVNPKGQVPALLLDDGTLLTEGVAIMQYLADSVPDRQLLAPVNSISRYKTIEWLNYIATELHKGFTPLFRPDTPEEYKPTVRAQLEKKLQYVNEALKDEHWICGQRFTIADAYLFTVLRWAYAVKLNLEGLEHIAAFMQRMAERPEVQDALSAEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FE0</accession>
    <name>Q32FE0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">nth</name>
        <name evidence="12" type="ordered locus">SDY_1856</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001030343.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403456.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FE0"/>
    <dbReference type="STRING" id="300267.SDY_1856"/>
    <dbReference type="EnsemblBacteria" id="ABB61965">
        <property type="protein sequence ID" value="ABB61965"/>
        <property type="gene ID" value="SDY_1856"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1856"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2235"/>
    <dbReference type="HOGENOM" id="CLU_012862_3_0_6"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="38"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB61965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="211" mass="23552" checksum="FDBD977F14AD6FFB" modified="2005-12-06" version="1">MNKAKRLEILTRLRENNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAENIIKTCRILLEQHNGEVPEDRAALEALSGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVEEKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEKVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FG0</accession>
    <name>Q32FG0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucuronide permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uidB</name>
        <name evidence="8" type="ordered locus">SDY_1835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:galactoside symporter (TC 2.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FG0"/>
    <dbReference type="STRING" id="300267.SDY_1835"/>
    <dbReference type="EnsemblBacteria" id="ABB61945">
        <property type="protein sequence ID" value="ABB61945"/>
        <property type="gene ID" value="SDY_1835"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1835"/>
    <dbReference type="HOGENOM" id="CLU_027408_0_2_6"/>
    <dbReference type="OMA" id="RYVSGMI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018043">
        <property type="entry name" value="Na/Gal_symport_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00872">
        <property type="entry name" value="NA_GALACTOSIDE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="433" mass="47242" checksum="C582E3F0E3C69894" modified="2005-12-06" version="1">MGALFLLSYYTDVAGVGTAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRPFLLFGTAPLMIFSVLVFWVPTDWSHGSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFVCLAFLIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPSLKSSLQTLKRNRPLFMLCIGALCVLISTFAVSASSLFYVRYVLNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGTCGYLLFFWVSVWSLPVALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQVQTPEVIMGISTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEIDNRKKVQQQLISDITNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FG5</accession>
    <name>Q32FG5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 6">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">manA</name>
        <name evidence="8" type="ordered locus">SDY_1829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5 6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001170637.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403431.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FG5"/>
    <dbReference type="STRING" id="300267.SDY_1829"/>
    <dbReference type="EnsemblBacteria" id="ABB61940">
        <property type="protein sequence ID" value="ABB61940"/>
        <property type="gene ID" value="SDY_1829"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1829"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2202"/>
    <dbReference type="HOGENOM" id="CLU_026967_1_0_6"/>
    <dbReference type="OMA" id="DIGLFCG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="PTHR10309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="391" mass="42840" checksum="43F00C05220DAA90" modified="2005-12-06" version="1">MQKLINSVQNYAWGSKTALTELYGMENPSSQPMAELWMGAHPKSRSRVQNAAGDIVSLRDVIESDKSTLLGEAVAKRFGELPFLFKVLCAAQPLSIQVHPNKHNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREFSEIVSLLQPVAGAHPAIAHFLQQPDAERLSELFASLLNMQGEEKSRALAILKSALDSQQGEPWQTIRLISEFYPDDSGLFSPLLLNVVKLNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPANQLLTQPVKQGAELDFPIPVDDFAFSMHDLSDKETTISQQSAAILFCVEGDATLCKGSQQLQLKPGESAFIAANESPVTVKGHGRLARVYNKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FI6</accession>
    <name>SYFB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheT</name>
        <name type="ordered locus">SDY_1808</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000672334.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403410.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FI6"/>
    <dbReference type="SMR" id="Q32FI6"/>
    <dbReference type="STRING" id="300267.SDY_1808"/>
    <dbReference type="EnsemblBacteria" id="ABB61919">
        <property type="protein sequence ID" value="ABB61919"/>
        <property type="gene ID" value="SDY_1808"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1808"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2180"/>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_6"/>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000232087" description="Phenylalanine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="1">
        <location>
            <begin position="401"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="1">
        <location>
            <begin position="701"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <sequence length="795" mass="87371" checksum="72D27CC48BA59396" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FJ4</accession>
    <name>Q32FJ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_1800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FJ4"/>
    <dbReference type="EnsemblBacteria" id="ABB61911">
        <property type="protein sequence ID" value="ABB61911"/>
        <property type="gene ID" value="SDY_1800"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1800"/>
    <dbReference type="HOGENOM" id="CLU_010245_1_1_6"/>
    <dbReference type="OMA" id="NDHERRY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PTHR32057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="283" mass="32856" checksum="6C80A58A9236DEC6" modified="2005-12-06" version="1">MADFAIRHYWLHLEDDEDKYRLWFNDVVARTASLIAQWQTVGFAHGVMNTDNMSLLGLTLDYGPFGFLNDYELGFICNHSDHQGRYSFDNQPAVALWNLQRLAQTLSPFVAVDALNEALDSYQQVLLTHYGQRMRQKLGFITEQKEDNALLNELFSLMARERSDYTRTFCMLSLTEQHSTASPLRDEFIDRAAFDDWFARYRGRLQQDEVSDSERQQLMQSVNPALVLRNWLAQRAIEAAEKGDMTELHRLHGALRNPFSDRDDDYVSRPPDWGKRLEVSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FU0</accession>
    <name>Q32FU0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FU0"/>
    <dbReference type="EnsemblBacteria" id="ABB61815">
        <property type="protein sequence ID" value="ABB61815"/>
        <property type="gene ID" value="SDY_1694"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1694"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="77" mass="8527" checksum="BAB56AFC97154FC9" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGTTKKTTIIMMGVAIIVVLGTELGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FU5</accession>
    <name>Q32FU5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative amino acid/amine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yeaN</name>
        <name evidence="8" type="ordered locus">SDY_1689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000752434.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403301.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FU5"/>
    <dbReference type="STRING" id="300267.SDY_1689"/>
    <dbReference type="EnsemblBacteria" id="ABB61810">
        <property type="protein sequence ID" value="ABB61810"/>
        <property type="gene ID" value="SDY_1689"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1689"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2036"/>
    <dbReference type="HOGENOM" id="CLU_038046_1_0_6"/>
    <dbReference type="OMA" id="RDPLAWQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004747">
        <property type="entry name" value="Cyan_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00896">
        <property type="entry name" value="CynX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="13"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="393" mass="41280" checksum="2D9475A6830C9B93" modified="2005-12-06" version="1">MACSNSLSGKNRIVLIAGILMIATTLRVTFTGASPLLDTIRSAYSLTTAQTGLLTTLPLLAFALISPLAAPVARRFGMERSLFAALLLICAGITIRSLPSPYLLFGGTAVIGGGIALGNVLLPGLIKRDFPHSVARLTGAYSLTMGAAAALGSAMVVPLALNGFGWQGALLMLMCFPLLALFLWLPQWRSQQHANLSTSRALHTRGIWRSPLAWQVTLFLGINSLIYYVIIGWLPAILISHGYSEAQAGSLHGLLQLATAAPGLLIPLFLHHVKDQRGIAAFVALMCAVGAVGLCFMPAHAITWTLLFGFGSGATMILGLTFIGLRASSAHQVAALSGMAQSVGYLLAACGPPLMGKIHDANGDWSVPLMGVAILSLLMAIFGLCAGRDKEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FZ7</accession>
    <name>Q32FZ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403249.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FZ7"/>
    <dbReference type="STRING" id="300267.SDY_1634"/>
    <dbReference type="EnsemblBacteria" id="ABB61758">
        <property type="protein sequence ID" value="ABB61758"/>
        <property type="gene ID" value="SDY_1634"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1634"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1968"/>
    <dbReference type="HOGENOM" id="CLU_1293585_0_0_6"/>
    <dbReference type="OMA" id="HPDHHTA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="213" mass="24433" checksum="5C71190AD1C09CF3" modified="2005-12-06" version="1">MVTPVSISNYISLPDDFPVRNIAPQVKEVLKDFIDALSTIICNEEWRTSLNINSAAKKIFNNLDNLSYIQRTSFRGNDTLYNEKVQFKLTYPARNGRHKENIEFQVVINLSPIYLDNFRHDGEINIFCAPNPKPVTMGRVFQTGVERVLFLFLNDFIEQFPMINPGVPIKRAHTPHIEPLPPDHHTAADYLRQFDLLVLNFISRGNFVGDASN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GX3</accession>
    <name>YCHJ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0225 protein YchJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ychJ</name>
        <name type="ordered locus">SDY_1285</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0225 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378677.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402923.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GX3"/>
    <dbReference type="SMR" id="Q32GX3"/>
    <dbReference type="STRING" id="300267.SDY_1285"/>
    <dbReference type="EnsemblBacteria" id="ABB61432">
        <property type="protein sequence ID" value="ABB61432"/>
        <property type="gene ID" value="SDY_1285"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1285"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1523"/>
    <dbReference type="HOGENOM" id="CLU_099590_0_0_6"/>
    <dbReference type="OMA" id="WLYVDGD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00612">
        <property type="entry name" value="UPF0225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023006">
        <property type="entry name" value="UPF0225"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000056742" description="UPF0225 protein YchJ">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00612"/>
        </source>
    </evidence>
    <sequence length="152" mass="16950" checksum="BA3FF82CFCE0AAAB" modified="2005-12-06" version="1">MSQLCPCGSAVEYSLCCHPYVSGEKVAPDPEHLMRSRYCAFVMQDADYLIKTWHPSCGAAALRAELIAGFAHTEWLGLTVFEHCWQDADNIGFVSFVARFIEGGKTGAIIERSRFLKENGQWYYIDGTRPQFGRNDPCPCGSGKKIKKCCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H12</accession>
    <name>Q32H12_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP-binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H12"/>
    <dbReference type="STRING" id="300267.SDY_1242"/>
    <dbReference type="EnsemblBacteria" id="ABB61393">
        <property type="protein sequence ID" value="ABB61393"/>
        <property type="gene ID" value="SDY_1242"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1242"/>
    <dbReference type="HOGENOM" id="CLU_1270822_0_0_6"/>
    <dbReference type="OMA" id="QHMLSGK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="201" mass="22362" checksum="2CC844768D102C97" modified="2005-12-06" version="1">MLNGKLEQSAEQLTTLGKTLGEEHRAAEQANLSSRFVGEAQAFATSPAANLRFYAARGPRGLETGLQGSLHTEAAELLGLHNVAQIADRHGLTQVSMENLLRWQPDIILVQEAVTADFIRRDPLWQGVKAVAEQRILFLSGLPFGWLDAPPGINRLLGLRRLHAWLDPAINRQFKSDMQHYAQLFWHCSLSDADYQKLVAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H78</accession>
    <name>CMOB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA U34 carboxymethyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cmoB</name>
        <name type="ordered locus">SDY_1170</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine = 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:52848"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="Rhea" id="RHEA-COMP:13383"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
            <dbReference type="ChEBI" id="CHEBI:136879"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000564728.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402818.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H78"/>
    <dbReference type="SMR" id="Q32H78"/>
    <dbReference type="STRING" id="300267.SDY_1170"/>
    <dbReference type="EnsemblBacteria" id="ABB61327">
        <property type="protein sequence ID" value="ABB61327"/>
        <property type="gene ID" value="SDY_1170"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1170"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1378"/>
    <dbReference type="HOGENOM" id="CLU_052665_0_0_6"/>
    <dbReference type="OMA" id="CEWRSDF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01590">
        <property type="entry name" value="tRNA_carboxymethyltr_CmoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010017">
        <property type="entry name" value="CmoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027555">
        <property type="entry name" value="Mo5U34_MeTrfas-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08003">
        <property type="entry name" value="Methyltransf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00452">
        <property type="entry name" value="TIGR00452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000313976" description="tRNA U34 carboxymethyltransferase">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01590"/>
        </source>
    </evidence>
    <sequence length="323" mass="37027" checksum="7967B06AD83607A1" modified="2005-12-06" version="1">MIDFGNFYSLIAKNHLSHWLETLPAQIANWQREQQHGLFKQWSNAVEFLPEIKPYRLDLLHSVTAESEEPLSAGQIKRIETLMRNLMPWRKGPFSLYGVNIDTEWRSDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGAHLAVGIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIEQLPALKAFDTVFSMGVLYHRRSPLEHLWQLKDQLVNEGELVLETLVIDGDENTVLVPGDRYAQMRNVYFIPSALALKNWLKKCGFVDIRIADVSVTTTEEQRRTEWMVTESLADFLDSHDPGKTVEGYPAPKRAVLITRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HF2</accession>
    <name>Q32HF2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="7">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fliD</name>
        <name evidence="10" type="ordered locus">SDY_1091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the FliD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000146756.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402744.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HF2"/>
    <dbReference type="STRING" id="300267.SDY_1091"/>
    <dbReference type="EnsemblBacteria" id="ABB61253">
        <property type="protein sequence ID" value="ABB61253"/>
        <property type="gene ID" value="SDY_1091"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1091"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1281"/>
    <dbReference type="HOGENOM" id="CLU_015182_8_1_6"/>
    <dbReference type="OMA" id="TLEWQRD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="FliD_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_C" evidence="9">
        <location>
            <begin position="219"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="465" mass="48180" checksum="1A33DDD34629A596" modified="2005-12-06" version="1">MASISSLGVGSGLDLSSILDSLTAAQKATLTPISNQQSSFTAKLSAYGTLKSALTTFQTANTALSKADLFSATSSTTAFSATTAGNAIAGKYTISVTHLAQAQTLTTRTTRDDTKTAIATSDSKLTIQQGGDKDPITIDISAANSSLSGIRDAINNAKAGVSASIINVGNGEYRLSVTSNDTGLDNAMTLSVSGDDALQSFMGYDASASSNGMEVSVAAQNAQLTVNNVAIENSSNTISDALENITLNLNDVTTGNQTLTITQDTSKAQTAIKDWVNAYNSLIDTFSSLTKYTAVDAGADSQSSSNGALLGDSTLRTIQTQLKSMLSNTVSSSNYKTLAQIGITTDPSDGKLELDADKLTAALKKDASGVGALIVGDGKKTGITTTIGSNLTSWLSTTGIIKAATDGVSNTLNKLTKDYNAASDRIDAQVARYKEQFTQLDVLMTSLNSTSSYLTQQFENNSNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HG7</accession>
    <name>Q32HG7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IAT_beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intimin/invasin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402729.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HG7"/>
    <dbReference type="STRING" id="300267.SDY_1075"/>
    <dbReference type="EnsemblBacteria" id="ABB61238">
        <property type="protein sequence ID" value="ABB61238"/>
        <property type="gene ID" value="SDY_1075"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1075"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1263"/>
    <dbReference type="HOGENOM" id="CLU_094221_0_0_6"/>
    <dbReference type="OMA" id="YRITLMA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024519">
        <property type="entry name" value="IAT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038177">
        <property type="entry name" value="IAT_beta_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003535">
        <property type="entry name" value="Intimin/invasin_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11924">
        <property type="entry name" value="IAT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01369">
        <property type="entry name" value="INTIMIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IAT_beta" evidence="2">
        <location>
            <begin position="2"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="258" mass="29731" checksum="C3DDEA86BA8C963E" modified="2005-12-06" version="1">MARGWASSQASGAMTDWLSRFGTARITLGVDEDFSLKNSQFDFLHPWYETPDNLFFSQHTLHRTDERTQINNGLGWRHFTPTWMSGINFFFDHDLSRYHSRAGIGAEYWRDYLKLSSNGYLRLTNWRSAPELDNDYEAHPANGWDVRAEGWLPAWPHLGGKLVYEQYYGDEVALFDKDDRQSNPHAITAGLNYTPFPLMTFSAEQRQGKQGENDTRFAVDFTWQPGSAMQKQLDPNEVDARRSLAGSRYDLVGRNNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HK2</accession>
    <name>Q32HK2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TR_THY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402694.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HK2"/>
    <dbReference type="STRING" id="300267.SDY_1038"/>
    <dbReference type="EnsemblBacteria" id="ABB61203">
        <property type="protein sequence ID" value="ABB61203"/>
        <property type="gene ID" value="SDY_1038"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1038"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1213"/>
    <dbReference type="HOGENOM" id="CLU_115536_3_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="PTHR10395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="SSF49472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220998" description="TR_THY domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="TR_THY" evidence="2">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="108" mass="11887" checksum="6C3AB805C1292B35" modified="2005-12-06" version="1">MLKRYLVLSVATAAFSLPSLVNAAQQNILSVHILNQQTGKPAADVTVTLEKKADNGWLQLDTAKTDKDGRIKALWPEQTATTGDYRVVFKTGDYFKKQNLESFGDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I39</accession>
    <name>Q32I39_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402507.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I39"/>
    <dbReference type="STRING" id="300267.SDY_0836"/>
    <dbReference type="EnsemblBacteria" id="ABB61018">
        <property type="protein sequence ID" value="ABB61018"/>
        <property type="gene ID" value="SDY_0836"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0836"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.963"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27592" checksum="6E4C697F34319618" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLACLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPLAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLRNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I46</accession>
    <name>Q32I46_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Malonyl-[acyl-carrier protein] O-methyltransferase</fullName>
            <shortName evidence="5">Malonyl-ACP O-methyltransferase</shortName>
            <ecNumber evidence="3 5">2.1.1.197</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biotin synthesis protein BioC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">bioC</name>
        <name evidence="7" type="ordered locus">SDY_0829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17105"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9954"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78845"/>
            <dbReference type="EC" id="2.1.1.197"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.197" evidence="3 5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000246789.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402500.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I46"/>
    <dbReference type="STRING" id="300267.SDY_0829"/>
    <dbReference type="EnsemblBacteria" id="ABB61011">
        <property type="protein sequence ID" value="ABB61011"/>
        <property type="gene ID" value="SDY_0829"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0829"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.955"/>
    <dbReference type="HOGENOM" id="CLU_046586_2_2_6"/>
    <dbReference type="OMA" id="SWQAVDG"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010340">
        <property type="term" value="F:carboxyl-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102130">
        <property type="term" value="F:malonyl-CoA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00835">
        <property type="entry name" value="BioC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011814">
        <property type="entry name" value="BioC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02072">
        <property type="entry name" value="BioC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="6">
        <location>
            <begin position="47"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="251" mass="28296" checksum="7542FEAA25F02600" modified="2005-12-06" version="1">MATVNKQAIAAAFGRAAAHYEQHAELQRQSADVLLAMLPQRKYTHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLAQARHKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVHPGGVVAFTTLVQGSLPELHQAWQAVDERPHANRFLPPDEIEQSLNGVHYRHHIQPITLWFDDALSAMRSLKGIGATHLHEGRDQRILTRSQLQRLQLAWPQQQGRYPLTYHLFLGVIVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I96</accession>
    <name>Q32I96_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ybiS</name>
        <name evidence="10" type="ordered locus">SDY_0777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001056384.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402450.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I96"/>
    <dbReference type="SMR" id="Q32I96"/>
    <dbReference type="STRING" id="300267.SDY_0777"/>
    <dbReference type="MEROPS" id="C82.A04"/>
    <dbReference type="EnsemblBacteria" id="ABB60961">
        <property type="protein sequence ID" value="ABB60961"/>
        <property type="gene ID" value="SDY_0777"/>
    </dbReference>
    <dbReference type="GeneID" id="66670908"/>
    <dbReference type="KEGG" id="sdy:SDY_0777"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.895"/>
    <dbReference type="HOGENOM" id="CLU_046834_0_1_6"/>
    <dbReference type="OMA" id="QNRSGMP"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041597">
        <property type="entry name" value="Ldt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17969">
        <property type="entry name" value="Ldt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221145" evidence="7">
        <location>
            <begin position="25"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="8">
        <location>
            <begin position="101"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ldt_C" evidence="9">
        <location>
            <begin position="237"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="306" mass="33325" checksum="4D9DDED8B0ACD69F" modified="2005-12-06" version="1">MNMKLKTLFAAAFAVVGFCSTASAVTYPLPTDGSRLVGQNQVITIPEGNTQPLEYFAAEYQMGLSNMMEANPGVDTFLPKGGTVLNIPQQLILPDTVHEGIVINSAEMRLYYYPKGTNTVIVLPIGIGQLGKDTPINWTTKVERKKAGPTWTPTAKMHAEYRAAGEPLPAVVPAGPDNPMGLYALYIGRLYAIHGTNANFGIGLRVSHGCVRLRNEDIKFLFEKVPVGTRVQFIDEPVKATTEPDGSRYIEVHNPLSTTEAQFEGQEIVPITLTKSVQTVTGQPDVDQVVLDEAIKNRSGMPVRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IB4</accession>
    <name>Q32IB4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybiK</name>
        <name evidence="4" type="ordered locus">SDY_0759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000513793.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402432.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IB4"/>
    <dbReference type="STRING" id="300267.SDY_0759"/>
    <dbReference type="EnsemblBacteria" id="ABB60943">
        <property type="protein sequence ID" value="ABB60943"/>
        <property type="gene ID" value="SDY_0759"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0759"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.873"/>
    <dbReference type="HOGENOM" id="CLU_021603_1_0_6"/>
    <dbReference type="OMA" id="YSRMRWK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="207"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="321" mass="33434" checksum="833C2BAF19DA24D1" modified="2005-12-06" version="1">MGKAVIAIHGGAGAISRAQMSLQQELRYIEALSAIVETGQKMLEAGESALDVVTETVRLLEECPLFNAGIGAVFTRDETHELDACVMDGNTLKAGAVAGVSHLRNPVLAARLVMEQSPHVMMIGEGAENFAFAHGMERVSPEIFSTPLRYEQLMAAREEGATVLDHSGAPLDEKQKMGTVGAVALDLDGNLAAATSTGGMTNKLPGRVGDSPLVGAGCYANNASVAVSCTGTGEVFIRALAAYDIAALMDYGGLSLAEACERVVMEKLPALGGSGGLIAIDHEGNVALPFNTEGMYRAWGYAGDTPTTGIYREKGDTVATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IH9</accession>
    <name>Q32IH9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division coordinator CpoB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybgF</name>
        <name evidence="1" type="synonym">cpoB</name>
        <name evidence="4" type="ordered locus">SDY_0690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CpoB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000097577.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402367.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IH9"/>
    <dbReference type="STRING" id="300267.SDY_0690"/>
    <dbReference type="EnsemblBacteria" id="ABB60878">
        <property type="protein sequence ID" value="ABB60878"/>
        <property type="gene ID" value="SDY_0690"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0690"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.804"/>
    <dbReference type="HOGENOM" id="CLU_044315_4_0_6"/>
    <dbReference type="OMA" id="YWLGEVN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070206">
        <property type="term" value="P:protein trimerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02066">
        <property type="entry name" value="CpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034706">
        <property type="entry name" value="CpoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014162">
        <property type="entry name" value="CpoB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032519">
        <property type="entry name" value="YbgF_tri"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16331">
        <property type="entry name" value="TolA_bind_tri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02795">
        <property type="entry name" value="tol_pal_ybgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009992530" description="Cell division coordinator CpoB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="TolA_bind_tri" evidence="3">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="263" mass="28246" checksum="40694121B2F9C8C2" modified="2005-12-06" version="1" precursor="true">MSSNFRHQLLSLSLLVGIAAPWAAFAQAPISSVGSGSVEDRVTQLERISNAHSQLLTQLQQQLSDNQSDIDSLRGQIQENQYQLNQVVERQKQILLQIDSLSSGGAAAQSTSGEQSGAAASTTPTADAGTANAGAPVKSGDANTDYNAAIALVQDKSRQDDAMVAFQNFIKNYPDSTYLPNANYWLGQLNYNKGKKDDAAYYFASVVKNYPKSPKAADAMFKVGVIMQDKGDTAKAKAVYQQVISKYPGTDGAKQAQKRLNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IT4</accession>
    <name>Q32IT4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_0032</name>
        <name evidence="4" type="ordered locus">SDY_0569</name>
        <name evidence="5" type="ordered locus">SDY_4582</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401760.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402262.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405934.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60271">
        <property type="protein sequence ID" value="ABB60271"/>
        <property type="gene ID" value="SDY_0032"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60773">
        <property type="protein sequence ID" value="ABB60773"/>
        <property type="gene ID" value="SDY_0569"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64443">
        <property type="protein sequence ID" value="ABB64443"/>
        <property type="gene ID" value="SDY_4582"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0032"/>
    <dbReference type="KEGG" id="sdy:SDY_0569"/>
    <dbReference type="KEGG" id="sdy:SDY_4582"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.35"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14904" checksum="F07FD07D6C754B56" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHHQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IX8</accession>
    <name>ENTS_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enterobactin exporter EntS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">entS</name>
        <name type="ordered locus">SDY_0522</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of an export pathway for enterobactin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001041801.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402218.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IX8"/>
    <dbReference type="SMR" id="Q32IX8"/>
    <dbReference type="STRING" id="300267.SDY_0522"/>
    <dbReference type="EnsemblBacteria" id="ABB60729">
        <property type="protein sequence ID" value="ABB60729"/>
        <property type="gene ID" value="SDY_0522"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0522"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.615"/>
    <dbReference type="HOGENOM" id="CLU_034180_11_0_6"/>
    <dbReference type="OMA" id="TPDDMRG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042931">
        <property type="term" value="F:enterobactin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01436">
        <property type="entry name" value="MFS_EntS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023722">
        <property type="entry name" value="Enterobactin_exp_EntS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000227656" description="Enterobactin exporter EntS">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="77"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="308"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01436"/>
        </source>
    </evidence>
    <sequence length="416" mass="43323" checksum="084E56132561007F" modified="2005-12-06" version="1">MNKQSWLLNLSLLKTHPAFRAVFLARFISIVSLGLLGVAVPVQIQMMTHSTWQVGLSVTLTGGAMFVGLMVGGVLADRYERKKVILLARGTCGIGFIGLCLNALLPEPSLLAIYLLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVNSPMIGGLLLAIGGVAWNYGLAAAGTFITLLPLLSLPALPPPPQPREHPLKSLLAGFRFLLASPLVGGIALLGGLLTMASAVRVLYPALADNWQMSAAQIGFLYAAIPLGAAIGALTSGKLAHSARPGLLMLLSTLGSFLAIGLFGLMPMWILGVVCLALFGWLSAVSSLLQYTMLQTQTPEVMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLLLVLVELRHFRQTPPQVTASDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J19</accession>
    <name>Q32J19_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable peptide chain release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prfH</name>
        <name evidence="3" type="ordered locus">SDY_0481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402177.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J19"/>
    <dbReference type="STRING" id="300267.SDY_0481"/>
    <dbReference type="EnsemblBacteria" id="ABB60688">
        <property type="protein sequence ID" value="ABB60688"/>
        <property type="gene ID" value="SDY_0481"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0481"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.566"/>
    <dbReference type="HOGENOM" id="CLU_036856_4_0_6"/>
    <dbReference type="OMA" id="HKRKNWF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017509">
        <property type="entry name" value="Release_fac_PrfH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03072">
        <property type="entry name" value="release_prfH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="2">
        <location>
            <begin position="68"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="166" mass="18916" checksum="D9662CE713352D87" modified="2005-12-06" version="1">MLETETGRYSDTLRSALISLDGDNAWALSESWCGTIQWICLSPYRPHHGRKNWFLGIGRFTADEQEQSDAIRYETLRPSGPGGQHVNKTDSAVRATHLATGISVKVQSERSQHANKRLARLLIAWKLEQQQQENSAVLKSQRRMFHHQIERGNPRRTFTGMAFIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J56</accession>
    <name>Q32J56_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanosine-inosine kinase</fullName>
            <ecNumber evidence="3">2.7.1.73</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">gsk</name>
        <name evidence="5" type="ordered locus">SDY_0442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of guanosine and inosine to GMP and IMP, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + guanosine = ADP + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27710"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.73"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + inosine = ADP + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:21140"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.73"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; GMP biosynthesis via salvage pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from inosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.73" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000671594.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402140.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J56"/>
    <dbReference type="STRING" id="300267.SDY_0442"/>
    <dbReference type="EnsemblBacteria" id="ABB60651">
        <property type="protein sequence ID" value="ABB60651"/>
        <property type="gene ID" value="SDY_0442"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0442"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.524"/>
    <dbReference type="HOGENOM" id="CLU_060237_0_0_6"/>
    <dbReference type="OMA" id="LLGVMCN"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00647"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00909"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02246">
        <property type="entry name" value="Gua_Ino_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046405">
        <property type="entry name" value="IngK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="4">
        <location>
            <begin position="87"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="284"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="434" mass="48467" checksum="01CB81EB6D70F466" modified="2005-12-06" version="1">MKFPGKRKSKHYFPVNVRDPLLQQFQPENETSAAWVVGIDQTLVDIEAKVDDEFIERYGLSAGHSLVIEDDVAEALYQELKQKNLITHQFAGGTIGNTMHNYSVLADDRSVLLGVMCSNIEIGSYAYRYLCNTSSRTDLNYLQGVDGPIGRCFTLIGESGERTFAISPGHMNQLRAESIPEDVIAGASALVLTSYLVRCKPGEPMPEATMKAIEYAKKYNVPVVLTLGTKFVIAENPQWWQQFLKDHVSILAMNEDEAEALTGESDPLLASDKALDWVDLVLCTAGPIGLYMAGFTEDEAKRKTQHPLLPGAIAEFNQYEFSRAMRHKDCQNPLRVYSHIAPYMGGPEKIMNTNGAGDGALAALLHDITANSYHRSNVSNSSKHKFTWLTYSSLAQVCKYANRVSYQVLNQHSPRLTRGLPEREDSLEESYWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JK9</accession>
    <name>Q32JK9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybcI</name>
        <name evidence="2" type="ordered locus">SDY_0279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JK9"/>
    <dbReference type="STRING" id="300267.SDY_0279"/>
    <dbReference type="EnsemblBacteria" id="ABB60498">
        <property type="protein sequence ID" value="ABB60498"/>
        <property type="gene ID" value="SDY_0279"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0279"/>
    <dbReference type="HOGENOM" id="CLU_125861_2_0_6"/>
    <dbReference type="OMA" id="FTVWIPL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="114" mass="12177" checksum="26B7AE20E029CDEC" modified="2005-12-06" version="1">MPTVITHAAVPLCIGLGLGSKVIPPRLLFAGIILAMLPDADVLSFKFGVAYGNVFGHRGFTHSLVFAFVVPLLCVLIGRRWFRAGLIRCWLFLTVSLLSHSLLDSVTTGGKGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JL3</accession>
    <name>Q32JL3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ordered locus">SDY_0275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378555.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401983.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JL3"/>
    <dbReference type="STRING" id="300267.SDY_0275"/>
    <dbReference type="EnsemblBacteria" id="ABB60494">
        <property type="protein sequence ID" value="ABB60494"/>
        <property type="gene ID" value="SDY_0275"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0275"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.315"/>
    <dbReference type="HOGENOM" id="CLU_094982_2_2_6"/>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="169" mass="17807" checksum="564745B8D4D871DA" modified="2005-12-06" version="1">MSSRNNPARVAIVMGSKSDWATMQFAAEIFEILNVPHHVEVVSAHRTPDKLFSFAESAEENGYQVIIAGAGGAAHLPGMIAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLAIGKAGAANAALLAAQILAIHDKELHQRLEDWRKAQTDEVLENPDPRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JT3</accession>
    <name>Q32JT3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc metalloprotease</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">yaeL</name>
        <name evidence="12" type="ordered locus">SDY_0192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378573.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401913.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JT3"/>
    <dbReference type="STRING" id="300267.SDY_0192"/>
    <dbReference type="MEROPS" id="M50.004"/>
    <dbReference type="EnsemblBacteria" id="ABB60424">
        <property type="protein sequence ID" value="ABB60424"/>
        <property type="gene ID" value="SDY_0192"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0192"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.223"/>
    <dbReference type="HOGENOM" id="CLU_025778_0_2_6"/>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="199"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB60424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="450" mass="49065" checksum="A8294B2293FAC669" modified="2005-12-06" version="1">MLSFLWDLASFIVALGVLITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDKLGTEYVIALIPLGGYVKMLDERAEPVVPELRHHAFNNKSVGQRAAIIAAGPVANFIFAIFAYWLVFIIGVPGVRPVVGEIAANSIASEAQIAPGTELKAVDGIETPDWDAVRLQLVDKIGDESTTITVAPFGSDQRRDVKLDLRHWAFEPDKEDPVSSLGIRPRGPQIEPVLENVQPNSAASKAGLQAGDRIVKVDGQPLTQWVTFVMLVRDNPGKSLALEIGRQGSPLSLTLIPESKPGNGKAIGFVGIEPKVIPLPDEYKVVRQYGPFNSIVEATDKTWQLMKLTVSMLGKLITGDVKLNNLSGPISIAKGAGMTAELGVVYYLPFLALISVNLGIINLFPFPVLDGGHLLFLAIEKIKGGPVSERVQDFCYRIGSILLVLLMGLALFNDFSRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JW8</accession>
    <name>PANC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantothenate synthetase</fullName>
            <shortName evidence="1">PS</shortName>
            <ecNumber evidence="1">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">panC</name>
        <name type="ordered locus">SDY_0155</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000905364.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401878.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JW8"/>
    <dbReference type="SMR" id="Q32JW8"/>
    <dbReference type="STRING" id="300267.SDY_0155"/>
    <dbReference type="EnsemblBacteria" id="ABB60389">
        <property type="protein sequence ID" value="ABB60389"/>
        <property type="gene ID" value="SDY_0155"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0155"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.175"/>
    <dbReference type="HOGENOM" id="CLU_047148_0_0_6"/>
    <dbReference type="OMA" id="CNHKLEP"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000305552" description="Pantothenate synthetase">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>beta-alanine</name>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <sequence length="283" mass="31497" checksum="BC49CE686CCC314C" modified="2005-12-06" version="1">MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADVVVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYPNGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQCQIAPGLYKVLSSIADKLQAGERDLDEIIAIAGQELNEKGFRADDIQIRDADTLLEVSETSKRAVILVAAWLGDARLIDNKIVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K00</accession>
    <name>Q32K00_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="6 14">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ddlB</name>
        <name evidence="14" type="synonym">ddl</name>
        <name evidence="18" type="ordered locus">SDY_0122</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="6 14"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000130070.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401846.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K00"/>
    <dbReference type="STRING" id="300267.SDY_0122"/>
    <dbReference type="EnsemblBacteria" id="ABB60357">
        <property type="protein sequence ID" value="ABB60357"/>
        <property type="gene ID" value="SDY_0122"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0122"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.141"/>
    <dbReference type="HOGENOM" id="CLU_039268_1_2_6"/>
    <dbReference type="OMA" id="MQGLLEC"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="101"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB60357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="306" mass="32899" checksum="E97686473E29C3F5" modified="2005-12-06" version="1">MTDKIAVLLGGTSAEREVSLNSGAAVLAGLREGGIDAYPVDPKEVDVTQLKSMGFQKVFIALHGRGGEDGTLQGMLELMGLPYTGSGVMASALSMDKLRSKLLWQGAGLPVVPWVALTRAEFEKGLSDKQLAEISALGLPVIVKPSREGSSVGMSKVVAENALQDALRLAFQHDEEVLIEKWLSGQEFTVAILGEEILPSIRIQPSGTFYDYEAKYLSDETQYFCPAGLEASQEANLQALVLKAWTTLGCKGWGRIDVMLDSDGQFYLLEANTSPGMTSHSLVPMAARQAGMSFSQLVVRILELAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K39</accession>
    <name>Q32K39_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Co-chaperone protein DjlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yabH</name>
        <name evidence="7" type="synonym">djlA</name>
        <name evidence="10" type="ordered locus">SDY_0080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The transmembrane domain is a dimerization domain.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001200573.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401807.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K39"/>
    <dbReference type="SMR" id="Q32K39"/>
    <dbReference type="STRING" id="300267.SDY_0080"/>
    <dbReference type="EnsemblBacteria" id="ABB60318">
        <property type="protein sequence ID" value="ABB60318"/>
        <property type="gene ID" value="SDY_0080"/>
    </dbReference>
    <dbReference type="GeneID" id="58460805"/>
    <dbReference type="KEGG" id="sdy:SDY_0080"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.90"/>
    <dbReference type="HOGENOM" id="CLU_066221_1_0_6"/>
    <dbReference type="OMA" id="MQYWGKL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01153">
        <property type="entry name" value="DjlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023749">
        <property type="entry name" value="DjlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Periplasmic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="6"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
        <location>
            <begin position="32"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="205"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="271" mass="30565" checksum="F7A0F92DA681758F" modified="2005-12-06" version="1">MQYWGKIIGVAVALLMGGGFWGVVLGLLIGHMFDKARSRKMAWFANQRERQALFFATTFEVMGHLTKSKGRVTEADIHIASQLMDRMNLHGASRTAAQNAFRVGKSDNYPLREKMRQFRSVCFGRFDLIRMFLEIQIQAAFADGSLHPNERAVLYVIAEELGISRAQFDQFLRMMQGGAQFGGGYQQQSGGGNWQQAQRGPTLEDACNVLGVKPTDDATTIKRAYRKLMSEHHPDKLVAKGLPPEMMEMAKQKAQEIQQAYELIKQQKGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K65</accession>
    <name>Q32K65_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="6">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">carA</name>
        <name evidence="8" type="ordered locus">SDY_0054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020950.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401781.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K65"/>
    <dbReference type="STRING" id="300267.SDY_0054"/>
    <dbReference type="MEROPS" id="C26.954"/>
    <dbReference type="EnsemblBacteria" id="ABB60292">
        <property type="protein sequence ID" value="ABB60292"/>
        <property type="gene ID" value="SDY_0054"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0054"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.59"/>
    <dbReference type="HOGENOM" id="CLU_035901_1_1_6"/>
    <dbReference type="OMA" id="CFNTGMT"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="7">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="382" mass="41488" checksum="D14C3AFA56CB8C96" modified="2005-12-06" version="1">MIKSALLVLEDGTQFHGRTIGATGSAVGEVVFNTSMTGYQEILTDPSYSRQIVTLTYPHIGNVGTNDADEESSQVHAQGLVIRDLPLIASNFRNTEDLSSYLKRHNIVAIADIDTRKLTRLLREKGAQNGCIIAGDNPDAALALEKARAFPGLNGMDLAKEVTTAEAYSWTQGSWKLTGGLPEAKKEDELPFHVVAYDFGAKRNILRMLVDRGCRLTIVPAQTSAEDVLKMNPDGIFLSNGPGDPAPCDYAITAIQKFLETDIPVFGICLGHQLLALASGAKTVKMKFGHHGGNHPVKDVEKNVVMITAQNHGFAVDEATLPANLRVTHKSLFDGTLQGIHRTDKPAFSFQGHPEASPGPHDAAPLFDHFIELIEQYRKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K94</accession>
    <name>Q32K94_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_0024</name>
        <name evidence="133" type="ordered locus">SDY_0031</name>
        <name evidence="9" type="ordered locus">SDY_0043</name>
        <name evidence="10" type="ordered locus">SDY_0085</name>
        <name evidence="11" type="ordered locus">SDY_0096</name>
        <name evidence="12" type="ordered locus">SDY_0150</name>
        <name evidence="13" type="ordered locus">SDY_0202</name>
        <name evidence="14" type="ordered locus">SDY_0237</name>
        <name evidence="15" type="ordered locus">SDY_0257</name>
        <name evidence="16" type="ordered locus">SDY_0273</name>
        <name evidence="17" type="ordered locus">SDY_0282</name>
        <name evidence="18" type="ordered locus">SDY_0375</name>
        <name evidence="19" type="ordered locus">SDY_0394</name>
        <name evidence="20" type="ordered locus">SDY_0401</name>
        <name evidence="21" type="ordered locus">SDY_0430</name>
        <name evidence="22" type="ordered locus">SDY_0466</name>
        <name evidence="23" type="ordered locus">SDY_0475</name>
        <name evidence="24" type="ordered locus">SDY_0499</name>
        <name evidence="25" type="ordered locus">SDY_0517</name>
        <name evidence="26" type="ordered locus">SDY_0543</name>
        <name evidence="27" type="ordered locus">SDY_0570</name>
        <name evidence="28" type="ordered locus">SDY_0657</name>
        <name evidence="29" type="ordered locus">SDY_0668</name>
        <name evidence="30" type="ordered locus">SDY_0670</name>
        <name evidence="31" type="ordered locus">SDY_0734</name>
        <name evidence="32" type="ordered locus">SDY_0888</name>
        <name evidence="33" type="ordered locus">SDY_0993</name>
        <name evidence="34" type="ordered locus">SDY_1056</name>
        <name evidence="35" type="ordered locus">SDY_1094</name>
        <name evidence="36" type="ordered locus">SDY_1156</name>
        <name evidence="37" type="ordered locus">SDY_1164</name>
        <name evidence="38" type="ordered locus">SDY_1199</name>
        <name evidence="39" type="ordered locus">SDY_1214</name>
        <name evidence="40" type="ordered locus">SDY_1267</name>
        <name evidence="41" type="ordered locus">SDY_1293</name>
        <name evidence="42" type="ordered locus">SDY_1297</name>
        <name evidence="43" type="ordered locus">SDY_1323</name>
        <name evidence="44" type="ordered locus">SDY_1336</name>
        <name evidence="45" type="ordered locus">SDY_1347</name>
        <name evidence="46" type="ordered locus">SDY_1360</name>
        <name evidence="47" type="ordered locus">SDY_1364</name>
        <name evidence="48" type="ordered locus">SDY_1381</name>
        <name evidence="49" type="ordered locus">SDY_1396</name>
        <name evidence="50" type="ordered locus">SDY_1412</name>
        <name evidence="51" type="ordered locus">SDY_1430</name>
        <name evidence="52" type="ordered locus">SDY_1439</name>
        <name evidence="53" type="ordered locus">SDY_1469</name>
        <name evidence="54" type="ordered locus">SDY_1479</name>
        <name evidence="55" type="ordered locus">SDY_1482</name>
        <name evidence="56" type="ordered locus">SDY_1494</name>
        <name evidence="57" type="ordered locus">SDY_1501</name>
        <name evidence="58" type="ordered locus">SDY_1544</name>
        <name evidence="59" type="ordered locus">SDY_1591</name>
        <name evidence="60" type="ordered locus">SDY_1616</name>
        <name evidence="61" type="ordered locus">SDY_1620</name>
        <name evidence="62" type="ordered locus">SDY_1714</name>
        <name evidence="63" type="ordered locus">SDY_1721</name>
        <name evidence="64" type="ordered locus">SDY_1745</name>
        <name evidence="65" type="ordered locus">SDY_1753</name>
        <name evidence="66" type="ordered locus">SDY_1771</name>
        <name evidence="67" type="ordered locus">SDY_1823</name>
        <name evidence="68" type="ordered locus">SDY_1906</name>
        <name evidence="69" type="ordered locus">SDY_1934</name>
        <name evidence="70" type="ordered locus">SDY_1958</name>
        <name evidence="71" type="ordered locus">SDY_2136</name>
        <name evidence="72" type="ordered locus">SDY_2251</name>
        <name evidence="73" type="ordered locus">SDY_2289</name>
        <name evidence="74" type="ordered locus">SDY_2307</name>
        <name evidence="75" type="ordered locus">SDY_2445</name>
        <name evidence="76" type="ordered locus">SDY_2466</name>
        <name evidence="77" type="ordered locus">SDY_2540</name>
        <name evidence="78" type="ordered locus">SDY_2549</name>
        <name evidence="79" type="ordered locus">SDY_2554</name>
        <name evidence="80" type="ordered locus">SDY_2568</name>
        <name evidence="81" type="ordered locus">SDY_2850</name>
        <name evidence="82" type="ordered locus">SDY_2871</name>
        <name evidence="83" type="ordered locus">SDY_2935</name>
        <name evidence="84" type="ordered locus">SDY_2956</name>
        <name evidence="85" type="ordered locus">SDY_2963</name>
        <name evidence="86" type="ordered locus">SDY_2994</name>
        <name evidence="87" type="ordered locus">SDY_3072</name>
        <name evidence="88" type="ordered locus">SDY_3104</name>
        <name evidence="89" type="ordered locus">SDY_3194</name>
        <name evidence="90" type="ordered locus">SDY_3225</name>
        <name evidence="91" type="ordered locus">SDY_3231</name>
        <name evidence="92" type="ordered locus">SDY_3280</name>
        <name evidence="93" type="ordered locus">SDY_3295</name>
        <name evidence="94" type="ordered locus">SDY_3315</name>
        <name evidence="95" type="ordered locus">SDY_3322</name>
        <name evidence="96" type="ordered locus">SDY_3444</name>
        <name evidence="97" type="ordered locus">SDY_3540</name>
        <name evidence="98" type="ordered locus">SDY_3584</name>
        <name evidence="99" type="ordered locus">SDY_3609</name>
        <name evidence="100" type="ordered locus">SDY_3628</name>
        <name evidence="101" type="ordered locus">SDY_3644</name>
        <name evidence="102" type="ordered locus">SDY_3811</name>
        <name evidence="103" type="ordered locus">SDY_3828</name>
        <name evidence="104" type="ordered locus">SDY_3854</name>
        <name evidence="105" type="ordered locus">SDY_3868</name>
        <name evidence="106" type="ordered locus">SDY_3884</name>
        <name evidence="107" type="ordered locus">SDY_3925</name>
        <name evidence="108" type="ordered locus">SDY_3928</name>
        <name evidence="109" type="ordered locus">SDY_4029</name>
        <name evidence="110" type="ordered locus">SDY_4095</name>
        <name evidence="111" type="ordered locus">SDY_4104</name>
        <name evidence="112" type="ordered locus">SDY_4108</name>
        <name evidence="113" type="ordered locus">SDY_4139</name>
        <name evidence="114" type="ordered locus">SDY_4164</name>
        <name evidence="115" type="ordered locus">SDY_4193</name>
        <name evidence="116" type="ordered locus">SDY_4215</name>
        <name evidence="117" type="ordered locus">SDY_4234</name>
        <name evidence="118" type="ordered locus">SDY_4245</name>
        <name evidence="119" type="ordered locus">SDY_4272</name>
        <name evidence="120" type="ordered locus">SDY_4321</name>
        <name evidence="121" type="ordered locus">SDY_4332</name>
        <name evidence="122" type="ordered locus">SDY_4338</name>
        <name evidence="123" type="ordered locus">SDY_4374</name>
        <name evidence="124" type="ordered locus">SDY_4387</name>
        <name evidence="125" type="ordered locus">SDY_4407</name>
        <name evidence="126" type="ordered locus">SDY_4438</name>
        <name evidence="127" type="ordered locus">SDY_4483</name>
        <name evidence="128" type="ordered locus">SDY_4501</name>
        <name evidence="129" type="ordered locus">SDY_4513</name>
        <name evidence="130" type="ordered locus">SDY_4519</name>
        <name evidence="131" type="ordered locus">SDY_4536</name>
        <name evidence="132" type="ordered locus">SDY_4558</name>
    </gene>
    <organism evidence="8 134">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 134" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 134">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABB60264.1"/>
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        <property type="protein sequence ID" value="ABB60281.1"/>
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        <property type="protein sequence ID" value="ABB60323.1"/>
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        <property type="protein sequence ID" value="ABB60332.1"/>
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        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0024"/>
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        <property type="protein sequence ID" value="ABB60264"/>
        <property type="gene ID" value="SDY_0024"/>
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    <dbReference type="EnsemblBacteria" id="ABB60281">
        <property type="protein sequence ID" value="ABB60281"/>
        <property type="gene ID" value="SDY_0043"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60323">
        <property type="protein sequence ID" value="ABB60323"/>
        <property type="gene ID" value="SDY_0085"/>
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    <dbReference type="EnsemblBacteria" id="ABB60332">
        <property type="protein sequence ID" value="ABB60332"/>
        <property type="gene ID" value="SDY_0096"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60384">
        <property type="protein sequence ID" value="ABB60384"/>
        <property type="gene ID" value="SDY_0150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60434">
        <property type="protein sequence ID" value="ABB60434"/>
        <property type="gene ID" value="SDY_0202"/>
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    <dbReference type="EnsemblBacteria" id="ABB60461">
        <property type="protein sequence ID" value="ABB60461"/>
        <property type="gene ID" value="SDY_0237"/>
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    <dbReference type="EnsemblBacteria" id="ABB60480">
        <property type="protein sequence ID" value="ABB60480"/>
        <property type="gene ID" value="SDY_0257"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60492">
        <property type="protein sequence ID" value="ABB60492"/>
        <property type="gene ID" value="SDY_0273"/>
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    <dbReference type="EnsemblBacteria" id="ABB60501">
        <property type="protein sequence ID" value="ABB60501"/>
        <property type="gene ID" value="SDY_0282"/>
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    <dbReference type="EnsemblBacteria" id="ABB60589">
        <property type="protein sequence ID" value="ABB60589"/>
        <property type="gene ID" value="SDY_0375"/>
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    <dbReference type="EnsemblBacteria" id="ABB60606">
        <property type="protein sequence ID" value="ABB60606"/>
        <property type="gene ID" value="SDY_0394"/>
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    <dbReference type="EnsemblBacteria" id="ABB60613">
        <property type="protein sequence ID" value="ABB60613"/>
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    <dbReference type="EnsemblBacteria" id="ABB60641">
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    <dbReference type="EnsemblBacteria" id="ABB60674">
        <property type="protein sequence ID" value="ABB60674"/>
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    <dbReference type="EnsemblBacteria" id="ABB60682">
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    <dbReference type="EnsemblBacteria" id="ABB60724">
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        <property type="gene ID" value="SDY_0517"/>
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    <dbReference type="EnsemblBacteria" id="ABB60748">
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    <dbReference type="EnsemblBacteria" id="ABB60774">
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    <dbReference type="EnsemblBacteria" id="ABB60845">
        <property type="protein sequence ID" value="ABB60845"/>
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    <dbReference type="EnsemblBacteria" id="ABB60856">
        <property type="protein sequence ID" value="ABB60856"/>
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    <dbReference type="EnsemblBacteria" id="ABB60858">
        <property type="protein sequence ID" value="ABB60858"/>
        <property type="gene ID" value="SDY_0670"/>
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    <dbReference type="EnsemblBacteria" id="ABB60918">
        <property type="protein sequence ID" value="ABB60918"/>
        <property type="gene ID" value="SDY_0734"/>
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    <dbReference type="EnsemblBacteria" id="ABB61065">
        <property type="protein sequence ID" value="ABB61065"/>
        <property type="gene ID" value="SDY_0888"/>
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    <dbReference type="EnsemblBacteria" id="ABB61160">
        <property type="protein sequence ID" value="ABB61160"/>
        <property type="gene ID" value="SDY_0993"/>
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    <dbReference type="EnsemblBacteria" id="ABB61221">
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        <property type="protein sequence ID" value="ABB61255"/>
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    <dbReference type="EnsemblBacteria" id="ABB61313">
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        <property type="protein sequence ID" value="ABB61321"/>
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        <property type="gene ID" value="SDY_1199"/>
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        <property type="protein sequence ID" value="ABB61367"/>
        <property type="gene ID" value="SDY_1214"/>
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        <property type="protein sequence ID" value="ABB61416"/>
        <property type="gene ID" value="SDY_1267"/>
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    <dbReference type="EnsemblBacteria" id="ABB61440">
        <property type="protein sequence ID" value="ABB61440"/>
        <property type="gene ID" value="SDY_1293"/>
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    <dbReference type="EnsemblBacteria" id="ABB61444">
        <property type="protein sequence ID" value="ABB61444"/>
        <property type="gene ID" value="SDY_1297"/>
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        <property type="protein sequence ID" value="ABB61470"/>
        <property type="gene ID" value="SDY_1323"/>
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        <property type="protein sequence ID" value="ABB61483"/>
        <property type="gene ID" value="SDY_1336"/>
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        <property type="protein sequence ID" value="ABB61494"/>
        <property type="gene ID" value="SDY_1347"/>
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        <property type="protein sequence ID" value="ABB61506"/>
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    <dbReference type="EnsemblBacteria" id="ABB61509">
        <property type="protein sequence ID" value="ABB61509"/>
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        <property type="protein sequence ID" value="ABB61526"/>
        <property type="gene ID" value="SDY_1381"/>
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        <property type="protein sequence ID" value="ABB61541"/>
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        <property type="protein sequence ID" value="ABB61556"/>
        <property type="gene ID" value="SDY_1412"/>
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        <property type="protein sequence ID" value="ABB61573"/>
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        <property type="protein sequence ID" value="ABB61621"/>
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        <property type="gene ID" value="SDY_1494"/>
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        <property type="protein sequence ID" value="ABB62059"/>
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        <property type="protein sequence ID" value="ABB62331"/>
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        <property type="protein sequence ID" value="ABB62618"/>
        <property type="gene ID" value="SDY_2549"/>
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        <property type="gene ID" value="SDY_2554"/>
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        <property type="protein sequence ID" value="ABB62632"/>
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        <property type="gene ID" value="SDY_2871"/>
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        <property type="gene ID" value="SDY_2956"/>
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    <evidence type="ECO:0000313" key="87">
        <source>
            <dbReference type="EMBL" id="ABB63089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="88">
        <source>
            <dbReference type="EMBL" id="ABB63119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="89">
        <source>
            <dbReference type="EMBL" id="ABB63204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="90">
        <source>
            <dbReference type="EMBL" id="ABB63233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="91">
        <source>
            <dbReference type="EMBL" id="ABB63239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="92">
        <source>
            <dbReference type="EMBL" id="ABB63278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="93">
        <source>
            <dbReference type="EMBL" id="ABB63292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="94">
        <source>
            <dbReference type="EMBL" id="ABB63311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="95">
        <source>
            <dbReference type="EMBL" id="ABB63316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="96">
        <source>
            <dbReference type="EMBL" id="ABB63432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="97">
        <source>
            <dbReference type="EMBL" id="ABB63516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="98">
        <source>
            <dbReference type="EMBL" id="ABB63558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="99">
        <source>
            <dbReference type="EMBL" id="ABB63580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="100">
        <source>
            <dbReference type="EMBL" id="ABB63597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="101">
        <source>
            <dbReference type="EMBL" id="ABB63612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="102">
        <source>
            <dbReference type="EMBL" id="ABB63756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="103">
        <source>
            <dbReference type="EMBL" id="ABB63773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="104">
        <source>
            <dbReference type="EMBL" id="ABB63796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="105">
        <source>
            <dbReference type="EMBL" id="ABB63810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="106">
        <source>
            <dbReference type="EMBL" id="ABB63824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="107">
        <source>
            <dbReference type="EMBL" id="ABB63859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="108">
        <source>
            <dbReference type="EMBL" id="ABB63862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="109">
        <source>
            <dbReference type="EMBL" id="ABB63947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="110">
        <source>
            <dbReference type="EMBL" id="ABB64009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="111">
        <source>
            <dbReference type="EMBL" id="ABB64017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="112">
        <source>
            <dbReference type="EMBL" id="ABB64020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="113">
        <source>
            <dbReference type="EMBL" id="ABB64049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="114">
        <source>
            <dbReference type="EMBL" id="ABB64073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="115">
        <source>
            <dbReference type="EMBL" id="ABB64098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="116">
        <source>
            <dbReference type="EMBL" id="ABB64119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="117">
        <source>
            <dbReference type="EMBL" id="ABB64135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="118">
        <source>
            <dbReference type="EMBL" id="ABB64146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="119">
        <source>
            <dbReference type="EMBL" id="ABB64173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="120">
        <source>
            <dbReference type="EMBL" id="ABB64215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="121">
        <source>
            <dbReference type="EMBL" id="ABB64224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="122">
        <source>
            <dbReference type="EMBL" id="ABB64229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="123">
        <source>
            <dbReference type="EMBL" id="ABB64261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="124">
        <source>
            <dbReference type="EMBL" id="ABB64274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="125">
        <source>
            <dbReference type="EMBL" id="ABB64294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="126">
        <source>
            <dbReference type="EMBL" id="ABB64321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="127">
        <source>
            <dbReference type="EMBL" id="ABB64359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="128">
        <source>
            <dbReference type="EMBL" id="ABB64376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="129">
        <source>
            <dbReference type="EMBL" id="ABB64388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="130">
        <source>
            <dbReference type="EMBL" id="ABB64393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="131">
        <source>
            <dbReference type="EMBL" id="ABB64410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="132">
        <source>
            <dbReference type="EMBL" id="ABB64425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="133">
        <source>
            <dbReference type="EMBL" id="ABB64512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="134">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="9898" checksum="E889588966B91FD4" modified="2005-12-06" version="1">MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVSLNTILRHLKNSGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32KB6</accession>
    <name>Q32KB6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Bifunctional aspartokinase/homoserine dehydrogenase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">Aspartokinase</fullName>
                <ecNumber evidence="21">2.7.2.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Homoserine dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.3</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="23" type="primary">thrA</name>
        <name evidence="23" type="ordered locus">SDY_0002</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 21">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 21">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 21">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 21">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 21">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 21">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 21">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 21">In the C-terminal section; belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 21">In the N-terminal section; belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="21"/>
    <dbReference type="EC" id="1.1.1.3" evidence="21"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021004.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401730.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32KB6"/>
    <dbReference type="STRING" id="300267.SDY_0002"/>
    <dbReference type="EnsemblBacteria" id="ABB60242">
        <property type="protein sequence ID" value="ABB60242"/>
        <property type="gene ID" value="SDY_0002"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0002"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1"/>
    <dbReference type="HOGENOM" id="CLU_009116_7_1_6"/>
    <dbReference type="OMA" id="CNKIACS"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04257">
        <property type="entry name" value="AAK_AK-HSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041743">
        <property type="entry name" value="AK-HSDH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_aspartokin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="entry name" value="PTHR43070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000727">
        <property type="entry name" value="ThrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 21" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="17 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 21 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18 21" id="KW-0521">NADP</keyword>
    <keyword evidence="15 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="13 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="22">
        <location>
            <begin position="320"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="22">
        <location>
            <begin position="401"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00007952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00010046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ABB60242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="820" mass="89180" checksum="5EFB87590F473B6F" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q326P5</accession>
    <name>Q326P5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406201.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326P5"/>
    <dbReference type="EnsemblBacteria" id="ABB64713">
        <property type="protein sequence ID" value="ABB64713"/>
        <property type="gene ID" value="SDY_P200"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P200"/>
    <dbReference type="HOGENOM" id="CLU_2865378_0_0_6"/>
    <dbReference type="OMA" id="DCAGEEQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7298" checksum="01241C4014A9EBFE" modified="2005-12-06" version="1">MTAAALLAEMPESSSLSRREISALVGVAQVNRDSGTLRGRRTIFGDCAGEEQLCTWRRLRHPGLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q326S9</accession>
    <name>Q326S9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">IpaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ipaB</name>
        <name evidence="12" type="ordered locus">SDY_P166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="12 13">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Sd197</strain>
            <plasmid evidence="13">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000552051.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406167.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326S9"/>
    <dbReference type="EnsemblBacteria" id="ABB64679">
        <property type="protein sequence ID" value="ABB64679"/>
        <property type="gene ID" value="SDY_P166"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P166"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5725"/>
    <dbReference type="HOGENOM" id="CLU_027418_0_0_6"/>
    <dbReference type="OMA" id="KFASHSI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032391">
        <property type="entry name" value="SipB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006972">
        <property type="entry name" value="SseC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003895">
        <property type="entry name" value="T3SS_invasion_prot_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04888">
        <property type="entry name" value="SseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16535">
        <property type="entry name" value="T3SSipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01375">
        <property type="entry name" value="BACINVASINB"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="6" id="KW-1043">Host membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0614">Plasmid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="T3SSipB" evidence="11">
        <location>
            <begin position="76"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB64679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="580" mass="62190" checksum="D393DEC7C3430FB3" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Y8</accession>
    <name>Q326Y8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carbohydrate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">shf</name>
        <name evidence="2" type="ordered locus">SDY_P107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406108.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Y8"/>
    <dbReference type="EnsemblBacteria" id="ABB64620">
        <property type="protein sequence ID" value="ABB64620"/>
        <property type="gene ID" value="SDY_P107"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P107"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5662"/>
    <dbReference type="HOGENOM" id="CLU_030024_3_1_6"/>
    <dbReference type="OMA" id="TFEFHSH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="51"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="263" mass="31089" checksum="F658B33F10296EAB" modified="2005-12-06" version="1">MYHHVSHCPGLVTLSPVTFRKQMKWLAENNWKTLSSDELEFFYRGGKLPRKSVMLTFDDGYLDNWFQVYPLLKEFNLKAHIFLITGFIGNGPVRHSPGKEYSHRDCEHQIATGNADNVMLRWSEVNEMLQSGLVEFHVHTHTHTRWDKKFSSREEQCKHLRQDLLSGREYLKEMTGKCSKHLCWPEGYYNKDYIQVAEELGFYYLYTTERRMNAPAKGTTRIGRISTKERESCAWLKRRLFYYTTPFFSSLLAFHKGPRLPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q327B1</accession>
    <name>Q327B1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS100 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406085.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327B1"/>
    <dbReference type="EnsemblBacteria" id="ABB64597">
        <property type="protein sequence ID" value="ABB64597"/>
        <property type="gene ID" value="SDY_P084"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P084"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5634"/>
    <dbReference type="HOGENOM" id="CLU_2636088_0_0_6"/>
    <dbReference type="OMA" id="TRMVAFP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="77" mass="8948" checksum="16D6DFCD839E1EEA" modified="2005-12-06" version="1">MLHEEKLARHQRKQAMYTRMVAFPAVKMFEEYDFTFATGAPQKQLQSLRSLSFIERNENIVLQGTSDITNPWVGICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q327D0</accession>
    <name>Q327D0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iso-IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_P065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Sd197</strain>
            <plasmid evidence="9">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000639.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000644.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000700.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000718.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000728.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000770.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000778.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000839.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000863.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406066.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327D0"/>
    <dbReference type="EnsemblBacteria" id="ABB64578">
        <property type="protein sequence ID" value="ABB64578"/>
        <property type="gene ID" value="SDY_P065"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P065"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5612"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_0_6"/>
    <dbReference type="OMA" id="VEIDCRY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="10295" checksum="911C556B26572C63" modified="2005-12-06" version="1">MASVNIHCPRCQSAQVYRHGQNPKGHDRFRCRDCHRVFQLTYTYEARKPGIKELITEMAFNGAGVCDTARTLKIGINTVIRTLKNSRQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q327V1</accession>
    <name>Q327V1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-damage-inducible protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dinF</name>
        <name evidence="6" type="ordered locus">SDY_4530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327V1"/>
    <dbReference type="STRING" id="300267.SDY_4530"/>
    <dbReference type="EnsemblBacteria" id="ABB64404">
        <property type="protein sequence ID" value="ABB64404"/>
        <property type="gene ID" value="SDY_4530"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4530"/>
    <dbReference type="HOGENOM" id="CLU_012893_16_0_6"/>
    <dbReference type="OMA" id="MDGIWLA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PTHR42893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="459" mass="49601" checksum="8B115412A708DEA0" modified="2005-12-06" version="1">MPPGVAVCFSSLFIRLVCMAFLTSSDKALWHLALPMIFSNITVPLLGLVDTAVIGHLDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAYGAKNPQALARALVQPLLLALGAGALIALLRTPIIDLALHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVILLVVGNILNIVLDVWLVMGLHMNVQGAALATVIAEYATLLIGLLMVRKILKLRGISGEMLKTAWRGNFRRLLALNRDIMLRSLLLQFCFGAITVLGARLGSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSGQAYGARDGSQLLDVWRAACRQSGIVALLFSVVYLLAGEHIIALLTSLTQIQQLADRYFIWQVILPLVGVWCYLLDGMFIGATRAAEMRNSMAVAAAGFALTLLTLPWLGNHGLWLALTVFLALRGLSLAAIWRRHWCNGTWFAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q328E8</accession>
    <name>Q328E8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">amiB</name>
        <name evidence="6" type="ordered locus">SDY_4420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.</text>
            <dbReference type="EC" id="3.5.1.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000990295.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405798.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328E8"/>
    <dbReference type="STRING" id="300267.SDY_4420"/>
    <dbReference type="EnsemblBacteria" id="ABB64307">
        <property type="protein sequence ID" value="ABB64307"/>
        <property type="gene ID" value="SDY_4420"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4420"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5218"/>
    <dbReference type="HOGENOM" id="CLU_014322_2_3_6"/>
    <dbReference type="OMA" id="NADPMFK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220815" description="N-acetylmuramoyl-L-alanine amidase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="5">
        <location>
            <begin position="254"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="445" mass="48080" checksum="EA2EA8349D725A0A" modified="2005-12-06" version="1">MMYRIRNWLVATLLLLCAQVGAATLSDIQVSNGNQQARITLSFIGDPDYAFSHQSKRTVALDIKQTGVIQGLPLLFSGNNLVKAIRSGTPKDAQTLRLVVDLTENGKTEAVKRQNGSNYTVVFTINADAPPPPPPPPVVAKRVETPTVVAPRVSEPARNPFKMESNRTTGVISSNTVTRPAARATANTGDKIIIAIDAGHGGQDPGAIGPGGTREKNVTIAIARKLRTLLNDDPMFKGVLTRDGDYFISVMGRSDVARKQNANFLVSIHADAAPNRSATGASVWVLSNRRANSEMASWLEQHEKQSELLGGAGDVLANSQSDPYLSQAVLDLQFGHSQRVGYDVATSMISQLQRIGEIHKRRPEHASLGVLRSPDIPSVLVETGFISNNSEERLLASDDYQQQLAEAIYKGLRNYFLAHPMQSASQEATAQTASTVTTPDRTLPN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q328F6</accession>
    <name>PURA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylosuccinate synthetase</fullName>
            <shortName evidence="1">AMPSase</shortName>
            <shortName evidence="1">AdSS</shortName>
            <ecNumber evidence="1">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purA</name>
        <name type="ordered locus">SDY_4412</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000527955.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405790.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328F6"/>
    <dbReference type="SMR" id="Q328F6"/>
    <dbReference type="STRING" id="300267.SDY_4412"/>
    <dbReference type="EnsemblBacteria" id="ABB64299">
        <property type="protein sequence ID" value="ABB64299"/>
        <property type="gene ID" value="SDY_4412"/>
    </dbReference>
    <dbReference type="GeneID" id="66671910"/>
    <dbReference type="KEGG" id="sdy:SDY_4412"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5210"/>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_6"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000224319" description="Adenylosuccinate synthetase">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="41"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="300"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="332"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="415"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <sequence length="432" mass="47345" checksum="AAA862CA0F80DA70" modified="2005-12-06" version="1">MGNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEAVDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGATTGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPLAADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRTETMILRDPFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q328G4</accession>
    <name>Q328G4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl coenzyme A dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aidB</name>
        <name evidence="9" type="ordered locus">SDY_4404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405782.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328G4"/>
    <dbReference type="STRING" id="300267.SDY_4404"/>
    <dbReference type="EnsemblBacteria" id="ABB64291">
        <property type="protein sequence ID" value="ABB64291"/>
        <property type="gene ID" value="SDY_4404"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4404"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5201"/>
    <dbReference type="HOGENOM" id="CLU_016513_0_0_6"/>
    <dbReference type="OMA" id="GNVQCLD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01154">
        <property type="entry name" value="AidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034184">
        <property type="entry name" value="AidB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="186"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="290"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB64291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="542" mass="60821" checksum="7C5F252643C1DB70" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q328I8</accession>
    <name>Q328I8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transmembrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ytfF</name>
        <name evidence="6" type="ordered locus">SDY_4380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405758.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328I8"/>
    <dbReference type="STRING" id="300267.SDY_4380"/>
    <dbReference type="EnsemblBacteria" id="ABB64267">
        <property type="protein sequence ID" value="ABB64267"/>
        <property type="gene ID" value="SDY_4380"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4380"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5172"/>
    <dbReference type="HOGENOM" id="CLU_058004_0_0_6"/>
    <dbReference type="OMA" id="WYPLRNA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="324" mass="35543" checksum="BC18F651840A7CFC" modified="2005-12-06" version="1">MPVMISGVLYALLAGLMWGLIFVGPLIVPEYPAMLQSMGRYLALGLIALPIAWLGRVRPLQLARRDWLTALMLTMMGNLIYYFCLASAIQRTGAPVSTMIIGTLPVVIPVFANLLYSQRDGKLAWGKLAPALICIGIGLACVNIAELNHGLPNFDWAHYTSGIVRALVSVVCWAWYALRNARWLRENPDKHPMMWATAQALVTLPVSLIGYLVACYWLNTQTPDFSLPFGPRPLVFISLMVAIAVLCSWVGALCWNVASQRLPTVILGPLIVFETLAGLLYTFLLRQQMPPLMTLSGIALLVIGVVIAVRAKPEKPLTESVSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q328Q1</accession>
    <name>Q328Q1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS2 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
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            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405695.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328Q1"/>
    <dbReference type="EnsemblBacteria" id="ABB64204">
        <property type="protein sequence ID" value="ABB64204"/>
        <property type="gene ID" value="SDY_4308"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4308"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5084"/>
    <dbReference type="HOGENOM" id="CLU_027402_25_0_6"/>
    <dbReference type="OMA" id="MGPERRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="121" mass="13424" checksum="51F22542BB20E694" modified="2005-12-06" version="1">MIDVLGPEKRRRRTTQEKIAIAQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQIKELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q329F8</accession>
    <name>Q329F8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Big-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intimin/invasin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016589.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405538.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329F8"/>
    <dbReference type="STRING" id="300267.SDY_4137"/>
    <dbReference type="EnsemblBacteria" id="ABB64047">
        <property type="protein sequence ID" value="ABB64047"/>
        <property type="gene ID" value="SDY_4137"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4137"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4864"/>
    <dbReference type="HOGENOM" id="CLU_000210_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003344">
        <property type="entry name" value="Big_1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024519">
        <property type="entry name" value="IAT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038177">
        <property type="entry name" value="IAT_beta_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015217">
        <property type="entry name" value="Invasin_dom_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02369">
        <property type="entry name" value="Big_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11924">
        <property type="entry name" value="IAT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09134">
        <property type="entry name" value="Invasin_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00634">
        <property type="entry name" value="BID_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51127">
        <property type="entry name" value="BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big-1" evidence="2">
        <location>
            <begin position="405"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="504" mass="53963" checksum="CD857F013E360E44" modified="2005-12-06" version="1">MALFGKDERQNDPHAITAGLSYTPVPLISFSAEQRQGKQGENDTRIGMELTLQPGHSLQKQLDPAEVAARRSLVGSRYDLVDRNNNIVLEYLKKELVRLTLTDPLKGKPGEVKSLVSSLQTKYALKGYDIEAASLQSAGGKVAVSGKDIQVTIPPYRFTAMPETDNIYPIAVTAEDSKGNFSRREESMVVVEKPTLSLADSTLSVDLQILLADGKSTSMLTYTARDSSGKPIPGMTLKTQAKGLQDFALSEWKDNGNGTYTQIVTAGKTSGALSLMPQFNGDDIAKTPALIAIVANTASRADSTIETDQDNYVAGKPIVVKVTLRDDNGNGVTGRKELLKQTVKVDNTKADAVSAWTEESEGIYKASYTAHLIGDKLTAQLTMPGWQTKHSDAFSIAGDKDTAKIAAMQITANNTVARRDHNTVAVTVRDVHQNLLQGQNVTFTVVNGAAVFADPNGGIVTTDKDGIASVNLASDQAVNSLIKAEINGSSQSVEVSFTLAISRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q329G2</accession>
    <name>Q329G2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016596.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405534.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329G2"/>
    <dbReference type="STRING" id="300267.SDY_4133"/>
    <dbReference type="EnsemblBacteria" id="ABB64043">
        <property type="protein sequence ID" value="ABB64043"/>
        <property type="gene ID" value="SDY_4133"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4133"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4858"/>
    <dbReference type="HOGENOM" id="CLU_027634_4_0_6"/>
    <dbReference type="OMA" id="LQLAHAC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="333" mass="36916" checksum="5F84231B06E06B3D" modified="2005-12-06" version="1">MMERKGIIAAGNMLVDHVHQIIQWPERGWLAEITHSERSTGGAPLNVLLTLAKMRTGLPLQAVGLIGQDSDGDYIMAMLEQYHVNRQHVQRTTFAPTSMSQVMTDPSGQRTFFHSPGANRLLDLPAFDQLDNTMKIFHLGYLLLLDSLDMPDDVYGTRSARLLAQMRDTGFETSLDLVSRKGDPRYQPLVLPALRHLDYLVINELEAGEFSGLEIRLPNGEPHIAHIAAAARELLDAGVRQRVVIHCPEGAWGETPEQGRVWIPSQKLEQREIIGSVGAGDAFCAGFLYGCHERWTLTESIKLAHACTRASLLCANAIDGAKTLEELQTEMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q329G4</accession>
    <name>Q329G4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000830340.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405532.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329G4"/>
    <dbReference type="STRING" id="300267.SDY_4131"/>
    <dbReference type="EnsemblBacteria" id="ABB64041">
        <property type="protein sequence ID" value="ABB64041"/>
        <property type="gene ID" value="SDY_4131"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4131"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4856"/>
    <dbReference type="HOGENOM" id="CLU_1204311_0_0_6"/>
    <dbReference type="OMA" id="LPPFAYW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010864">
        <property type="entry name" value="D-lyxose_isomer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07385">
        <property type="entry name" value="Lyx_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="227" mass="25826" checksum="BBA3455CFD7DB638" modified="2005-12-06" version="1">MKRSAINDILGHTRQFFSQHDVHLPPFASFSPAQWQQLDTAAWEEVFDLKLGWDVTAFGRNNFAAHGLTLFTLRNGSAKGMPYVKCYAEKIMHVRDAQVTPMHFHWRKREDIINRGGGNLIVELWNADSNEQTADSDVTVVIDGCRQKHTAGTQLRLSPGESICLPPGLYHSFWAETGFGDVLVGEVSSVNDDDHDNHFLQPLDRYNLINEDEPAQLVLCNKYRQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A06</accession>
    <name>Q32A06_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH-type transcriptional regulator MetR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metR</name>
        <name evidence="8" type="ordered locus">SDY_3915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000573624.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405340.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A06"/>
    <dbReference type="STRING" id="300267.SDY_3915"/>
    <dbReference type="EnsemblBacteria" id="ABB63849">
        <property type="protein sequence ID" value="ABB63849"/>
        <property type="gene ID" value="SDY_3915"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3915"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4623"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_0_6"/>
    <dbReference type="OMA" id="YPVPDDM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08441">
        <property type="entry name" value="PBP2_MetR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037406">
        <property type="entry name" value="MetR_PBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="7">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="317" mass="35584" checksum="11F5FB74002386A1" modified="2005-12-06" version="1">MIEVKHLKTLQALRNCGSLAAAAATLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTPQGEILLQLANQVLPQISQALQACNEPQQTRLRIAIECHSCIQWLTPALENFHKNWPQVEMDFKSGVTFDPQPALQQGELDLVMTSDILPRSGLHYSPMFDYEVRLVLAPDHPLAAKTRITPEDLASKTLLIYPVQRSRLDVWRHFLQPAGVSPSLKSVDNTLLLIQMVAARMGIAALPHWVVESFERQGLVVTKTLGEGLWSRLYAAVRDGEQRQPITAAFIRSARNHACDHLPFVKSAERPTYDAPTVRPGSPARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A28</accession>
    <name>Q32A28_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yihD</name>
        <name evidence="1" type="ordered locus">SDY_3887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295263.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405318.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A28"/>
    <dbReference type="SMR" id="Q32A28"/>
    <dbReference type="STRING" id="300267.SDY_3887"/>
    <dbReference type="EnsemblBacteria" id="ABB63827">
        <property type="protein sequence ID" value="ABB63827"/>
        <property type="gene ID" value="SDY_3887"/>
    </dbReference>
    <dbReference type="GeneID" id="67417259"/>
    <dbReference type="KEGG" id="sdy:SDY_3887"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4600"/>
    <dbReference type="HOGENOM" id="CLU_170339_0_0_6"/>
    <dbReference type="OMA" id="KDEMIPG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009383">
        <property type="entry name" value="DUF1040"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038134">
        <property type="entry name" value="YihD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06288">
        <property type="entry name" value="DUF1040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="89" mass="10273" checksum="307E75C1D700DF92" modified="2005-12-06" version="1">MKCKRLNEVIELLQPAWQKEPDLNLLQFLQKLAKESGFDGELADLTDDILIYHLKMRDSAKDAVIPGLQKDYEEDFKTALLRARGVIKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A56</accession>
    <name>YIHY_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0761 membrane protein YihY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yihY</name>
        <name type="ordered locus">SDY_3857</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0761 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000920762.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405290.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A56"/>
    <dbReference type="STRING" id="300267.SDY_3857"/>
    <dbReference type="EnsemblBacteria" id="ABB63799">
        <property type="protein sequence ID" value="ABB63799"/>
        <property type="gene ID" value="SDY_3857"/>
    </dbReference>
    <dbReference type="GeneID" id="66672208"/>
    <dbReference type="KEGG" id="sdy:SDY_3857"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4557"/>
    <dbReference type="HOGENOM" id="CLU_032288_0_0_6"/>
    <dbReference type="OMA" id="KQPKFRW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00672">
        <property type="entry name" value="UPF0761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023679">
        <property type="entry name" value="UPF0761_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000044732" description="UPF0761 membrane protein YihY">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00672"/>
        </source>
    </evidence>
    <sequence length="290" mass="32839" checksum="E027DAB37200CA93" modified="2005-12-06" version="1">MLKTIQDKARHRTRPLWAWLKLLWQRIDEDNMTTLAGNLAYVSLLSLVPLVAVVFALFAAFPMFSDVSIQLRHFIFANFLPATGDVIQRYIEQFVANSNKMTAVGACGLIVTALLLMYSIDSALNTIWRSKRARPKIYSFAVYWMILTLGPLLAGASLAISSYLLSLRWASDLNTVIDNVLRIFPLLLSWISFWLLYSIVPTIRVPNRDAIVGAFVAALLFEAGKKGFALYITMFPSYQLIYGVLAVIPILFVWVYWTWCIVLLGAEITVTLGEYRKLKQAAEQEEDDEP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A68</accession>
    <name>RHAD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhamnulose-1-phosphate aldolase</fullName>
            <ecNumber evidence="1">4.1.2.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhaD</name>
        <name type="ordered locus">SDY_3844</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:19689"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58313"/>
            <dbReference type="EC" id="4.1.2.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. RhaD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.19" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001179718.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405278.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A68"/>
    <dbReference type="SMR" id="Q32A68"/>
    <dbReference type="STRING" id="300267.SDY_3844"/>
    <dbReference type="EnsemblBacteria" id="ABB63787">
        <property type="protein sequence ID" value="ABB63787"/>
        <property type="gene ID" value="SDY_3844"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3844"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4541"/>
    <dbReference type="HOGENOM" id="CLU_076831_0_0_6"/>
    <dbReference type="OMA" id="SHFMSHI"/>
    <dbReference type="UniPathway" id="UPA00541">
        <property type="reaction ID" value="UER00603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008994">
        <property type="term" value="F:rhamnulose-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00770">
        <property type="entry name" value="RhaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013447">
        <property type="entry name" value="Rhamnulose-1-P_Aldolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02624">
        <property type="entry name" value="rhamnu_1P_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0684">Rhamnose metabolism</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000017344" description="Rhamnulose-1-phosphate aldolase">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00770"/>
        </source>
    </evidence>
    <sequence length="274" mass="30171" checksum="D972A55858FA185C" modified="2005-12-06" version="1">MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIALYHDNFHPQPRYIPLSQPMHLLANTPFIVTGSGKFFRNVQLDPAANLGVVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKIYSMGGMKQTISREELIALGKRFGVTPLASALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AB3</accession>
    <name>Q32AB3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Soluble pyridine nucleotide transhydrogenase</fullName>
            <shortName evidence="11">STH</shortName>
            <ecNumber evidence="4 11">1.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">NAD(P)(+) transhydrogenase [B-specific]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sthA</name>
        <name evidence="11 15" type="synonym">udhA</name>
        <name evidence="15" type="ordered locus">SDY_3797</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NAD(+) + NADPH = NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11692"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.1.1" evidence="4 11"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AB3"/>
    <dbReference type="STRING" id="300267.SDY_3797"/>
    <dbReference type="EnsemblBacteria" id="ABB63742">
        <property type="protein sequence ID" value="ABB63742"/>
        <property type="gene ID" value="SDY_3797"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3797"/>
    <dbReference type="HOGENOM" id="CLU_016755_0_0_6"/>
    <dbReference type="OMA" id="CLMAVGA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003957">
        <property type="term" value="F:NAD(P)+ transhydrogenase (B-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00247">
        <property type="entry name" value="SthA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022962">
        <property type="entry name" value="STH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="14">
        <location>
            <begin position="3"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="13">
        <location>
            <begin position="324"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB63742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="444" mass="49404" checksum="9C3A43915400439C" modified="2005-12-06" version="1">MGLVKQGARVAVIERYQNVGGGCTHWGTIPSKALRHAVSRIIEFNQNSLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNARFVDEHTLALDCPDGSVETLTAEKFVIACGSRPYHPTDVDFTHPRIYDSDSILSMHHEPRHVLIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALQNIGLETDSRGQLKVNSMYQTAQPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AH5</accession>
    <name>Q32AH5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Zinc resistance-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yjaI</name>
        <name evidence="6" type="ordered locus">SDY_3724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Binds zinc. Could be an important component of the zinc-balancing mechanism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZraP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AH5"/>
    <dbReference type="STRING" id="300267.SDY_3724"/>
    <dbReference type="EnsemblBacteria" id="ABB63680">
        <property type="protein sequence ID" value="ABB63680"/>
        <property type="gene ID" value="SDY_3724"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3724"/>
    <dbReference type="HOGENOM" id="CLU_124884_0_0_6"/>
    <dbReference type="OMA" id="GMGYGDC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025961">
        <property type="entry name" value="Metal_resist"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13801">
        <property type="entry name" value="Metal_resist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="186" mass="20205" checksum="F26D6EBA4A5A5B84" modified="2005-12-06" version="1">MSKNDSLPAAGESFLLVYHARLPVISAFHRWHGRCNTRSKTTTGGLTMKRNTKIALVMMALSAMAMGSTSAFAHGGHGMWQQNAAPLTSEQQTAWQKIHNDFYAQISALQQKLVTKRYEYNALLAANPPDSSKINAVAKEMENLRQSLDELRVKRDIAMAEAGIPRGAGMGYGGCGGGGHMGMGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AM3</accession>
    <name>Q32AM3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">feoB</name>
        <name evidence="12" type="ordered locus">SDY_3667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000737013.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405123.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AM3"/>
    <dbReference type="SMR" id="Q32AM3"/>
    <dbReference type="STRING" id="300267.SDY_3667"/>
    <dbReference type="EnsemblBacteria" id="ABB63632">
        <property type="protein sequence ID" value="ABB63632"/>
        <property type="gene ID" value="SDY_3667"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3667"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4351"/>
    <dbReference type="HOGENOM" id="CLU_013350_3_0_6"/>
    <dbReference type="OMA" id="MEMPDYE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="11">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="773" mass="84471" checksum="F1F2AE234C949B92" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AM5</accession>
    <name>Q32AM5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhgA</name>
        <name evidence="3" type="ordered locus">SDY_3665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000039052.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405121.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AM5"/>
    <dbReference type="EnsemblBacteria" id="ABB63630">
        <property type="protein sequence ID" value="ABB63630"/>
        <property type="gene ID" value="SDY_3665"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3665"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4349"/>
    <dbReference type="HOGENOM" id="CLU_059548_1_0_6"/>
    <dbReference type="OMA" id="QEDIMTI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="2">
        <location>
            <begin position="8"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="292" mass="33269" checksum="2A85BFF4F9C723B5" modified="2005-12-06" version="1">MSKKQSSTPHDALFKLFLRQPDTARDFLAFHLPAPIHALCDMKTLKLESSSFIDDDLRESYSDVLWSVKTEQGLGYIYCLIEHQSTSNKLIAFRMMRYAIAAMQNHLDAGYKTLPMVVPLLFYHGIESPYPYSLCWLDCFADPNLARQLYASAFPLIDVTVMPDDEIMQHRRMALMELIQKHIRQRDLIGLVEQMACLLSSGYANDRQIKGLFNYILQTGDAVRFNDFIDGVAERSPKHKESLMTIAERLRQEGEQSKALHIAKIMLESGVPLADIMRFTGLSEEELAAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AM8</accession>
    <name>Q32AM8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">High-affinity transport of gluconate/gluconate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gntT</name>
        <name evidence="2" type="ordered locus">SDY_3661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001131760.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405118.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AM8"/>
    <dbReference type="STRING" id="300267.SDY_3661"/>
    <dbReference type="EnsemblBacteria" id="ABB63627">
        <property type="protein sequence ID" value="ABB63627"/>
        <property type="gene ID" value="SDY_3661"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3661"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4343"/>
    <dbReference type="HOGENOM" id="CLU_027949_0_0_6"/>
    <dbReference type="OMA" id="MVLPKGH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="438" mass="45997" checksum="7542882C4E08523A" modified="2005-12-06" version="1">MPLVIVAIGVILLLLLMIRFKMNGFIALVLVALAVGLMQGMPLDKVIGSIKAGVGGTLGSLALIMGFGAMLGKMLADCGGAQRIATTLIAKFGKKHIQWAVVLTGFTVGFALFYEVGFVLMLPLVFTIAASANIPLLYVGVPMAAALSVTHGFLPPHPGPTAIATIFNADMGKTLLYGTILAIPTVILAGPVYARVLKGIDKPIPEGLYSAKTFSEEEMPSFGVSVWTSLVPVVLMAMRAIAEMILPKGHAFLPVAEFLGDPVMATLIAVLIAMFTFGLNRGRSMDQINDTLVSSIKIIAMMLLIIGGGGAFKQVLVDSGVDKYIASMMHETNISPLLMAWSIAAVLRIALGSATVAAITAGGIAAPLIATTGVSPELMVIAVGSSSVIFSHVNDPGFWLFKEYFNLTIGETIKSWSMLETIISVCGLVGCLLLNMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AZ2</accession>
    <name>Q32AZ2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yhiV</name>
        <name evidence="7" type="ordered locus">SDY_3537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cell inner membrane</location>
            <topology evidence="2 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000024914.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405004.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AZ2"/>
    <dbReference type="STRING" id="300267.SDY_3537"/>
    <dbReference type="EnsemblBacteria" id="ABB63513">
        <property type="protein sequence ID" value="ABB63513"/>
        <property type="gene ID" value="SDY_3537"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3537"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4196"/>
    <dbReference type="HOGENOM" id="CLU_002755_0_1_6"/>
    <dbReference type="OMA" id="ITRHNMY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="923"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1009"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1039" mass="111846" checksum="D9F1C2B75020BC84" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B01</accession>
    <name>Q32B01_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Nitrite reductase (NAD(P)H) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">nirB</name>
        <name evidence="17" type="ordered locus">SDY_3527</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000049190.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404995.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B01"/>
    <dbReference type="STRING" id="300267.SDY_3527"/>
    <dbReference type="EnsemblBacteria" id="ABB63504">
        <property type="protein sequence ID" value="ABB63504"/>
        <property type="gene ID" value="SDY_3527"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3527"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4181"/>
    <dbReference type="HOGENOM" id="CLU_003291_0_0_6"/>
    <dbReference type="OMA" id="FAQVDPW"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="5"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="16">
        <location>
            <begin position="321"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="14">
        <location>
            <begin position="424"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="13">
        <location>
            <begin position="560"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="12">
        <location>
            <begin position="633"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB63504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="847" mass="93095" checksum="EDE43834C0B63EE7" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B06</accession>
    <name>Q32B06_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-aminobenzoate synthetase, component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pabA</name>
        <name evidence="2" type="ordered locus">SDY_3522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000601848.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404990.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B06"/>
    <dbReference type="STRING" id="300267.SDY_3522"/>
    <dbReference type="MEROPS" id="C26.955"/>
    <dbReference type="EnsemblBacteria" id="ABB63499">
        <property type="protein sequence ID" value="ABB63499"/>
        <property type="gene ID" value="SDY_3522"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3522"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4177"/>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_6"/>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="187" mass="20786" checksum="122F43499D5E0483" modified="2005-12-06" version="1">MILLIDNYDSFTWNLYQYFCELGADVLVKRNDALTLADIDALKPQKIVISPGPCTPDEAGISLDVIRHYAGRLPILGVCLGHQAMAQAFGGKVVRAAKVMHGKTSPITHNGEGVFRGLANPLTVTRYHSLVVEPDSLPACFEVTAWSETREIMGIRHRQWDLEGVQFHPESILSEQGHQLLANFLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B17</accession>
    <name>Q32B17_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">slyD</name>
        <name evidence="6" type="ordered locus">SDY_3510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000861327.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404979.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B17"/>
    <dbReference type="STRING" id="300267.SDY_3510"/>
    <dbReference type="EnsemblBacteria" id="ABB63488">
        <property type="protein sequence ID" value="ABB63488"/>
        <property type="gene ID" value="SDY_3510"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3510"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4164"/>
    <dbReference type="HOGENOM" id="CLU_098197_1_0_6"/>
    <dbReference type="OMA" id="HSHEGGC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="192" mass="20308" checksum="1683D2DFEA8B6031" modified="2005-12-06" version="1">MKVAKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLISGLETALEGHEVGDKFDVAVGANDAYGQYDENLVQRVPKDVFMGVDELQVGMRFLAETDQGPVPVEITAVEDDHVVVDGNHILAGQNLKFNVEVVAIREATEEELAHGHVHGAHDHDHDGCCGGHGHDHGHEHGGEGCCGGKGNGGCGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B28</accession>
    <name>Q32B28_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterioferritin-associated ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000289090.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404968.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B28"/>
    <dbReference type="STRING" id="300267.SDY_3499"/>
    <dbReference type="EnsemblBacteria" id="ABB63477">
        <property type="protein sequence ID" value="ABB63477"/>
        <property type="gene ID" value="SDY_3499"/>
    </dbReference>
    <dbReference type="GeneID" id="67415365"/>
    <dbReference type="KEGG" id="sdy:SDY_3499"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4153"/>
    <dbReference type="HOGENOM" id="CLU_159205_3_4_6"/>
    <dbReference type="OMA" id="MYVCLCE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_BFD" evidence="1">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="64" mass="7475" checksum="DC0C8C36C707F658" modified="2005-12-06" version="1">MYVCLCNGVSDKKIRQAVRQFHPQSFQQLRKFIPVGNQCGKCIRAAREVMQDELMQMPEFKEIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B44</accession>
    <name>RS14_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsN</name>
        <name type="ordered locus">SDY_3483</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001118930.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404952.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B44"/>
    <dbReference type="SMR" id="Q32B44"/>
    <dbReference type="STRING" id="300267.SDY_3483"/>
    <dbReference type="EnsemblBacteria" id="ABB63461">
        <property type="protein sequence ID" value="ABB63461"/>
        <property type="gene ID" value="SDY_3483"/>
    </dbReference>
    <dbReference type="GeneID" id="67415348"/>
    <dbReference type="KEGG" id="sdy:SDY_3483"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4136"/>
    <dbReference type="HOGENOM" id="CLU_139869_0_1_6"/>
    <dbReference type="OMA" id="FGLCRNQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000128589" description="30S ribosomal protein S14">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <sequence length="101" mass="11580" checksum="E2B21D9D3752352C" modified="2005-12-06" version="1">MAKQSMKAREVKRVALADKYFAKRAELKAIISDVNASDEDRWNAVLKLQTLPRDSSPSRQRNRCRQTGRPHGFLRKFGLSRIKVREAAMRGEIPGLKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B72</accession>
    <name>Q32B72_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative periplasmic binding transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhdW</name>
        <name evidence="6" type="ordered locus">SDY_3445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404924.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B72"/>
    <dbReference type="STRING" id="300267.SDY_3445"/>
    <dbReference type="EnsemblBacteria" id="ABB63433">
        <property type="protein sequence ID" value="ABB63433"/>
        <property type="gene ID" value="SDY_3445"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3445"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4103"/>
    <dbReference type="HOGENOM" id="CLU_019602_3_2_6"/>
    <dbReference type="OMA" id="RNTTWTF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="305" mass="33510" checksum="15DD501D904A81C5" modified="2005-12-06" version="1">MQCGISDGLPRFSYADADGKFSGIDVDVCRGVAAAVFGDNTKVKYTPLTAKERFTALQSGEVDLLSRNTTWTSSRDAGMGMAFTGVTYYDGIGFLTHDKAGLKSAKELDGATVCIQAGTDTELNVADYFKANNMKYTPVTFDRSDESAKALESGRCDTLASDQSQLYALRIKLSNPAEWIVLPEVISKEPLGPVVRRGDDEWFSIVRWTLFAMLNAEEMGINSQNVDEKAANPATPDMAHLLGKEGDYGKDLKLDNKWAYNIIKQVGNYSEIFERNVGSESPLKIKRGQNNLWNNGGIQYAPPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BB2</accession>
    <name>Q32BB2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BB2"/>
    <dbReference type="EnsemblBacteria" id="ABB63393">
        <property type="protein sequence ID" value="ABB63393"/>
        <property type="gene ID" value="SDY_3402"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3402"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="118" mass="13484" checksum="F6813899C03F9618" modified="2005-12-06" version="1">MAVKPGNTGSGTRITPKQGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTIRFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BC1</accession>
    <name>Q32BC1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate synthase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">gltB</name>
        <name evidence="16" type="ordered locus">SDY_3393</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000965040.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404875.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BC1"/>
    <dbReference type="STRING" id="300267.SDY_3393"/>
    <dbReference type="MEROPS" id="C44.003"/>
    <dbReference type="EnsemblBacteria" id="ABB63384">
        <property type="protein sequence ID" value="ABB63384"/>
        <property type="gene ID" value="SDY_3393"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3393"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4049"/>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_6"/>
    <dbReference type="OMA" id="TVFRLQH"/>
    <dbReference type="UniPathway" id="UPA00694"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="12"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB63384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1486" mass="163337" checksum="46CEDF11ADB61849" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BF6</accession>
    <name>Q32BF6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folP</name>
        <name evidence="3" type="ordered locus">SDY_3358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BF6"/>
    <dbReference type="STRING" id="300267.SDY_3358"/>
    <dbReference type="EnsemblBacteria" id="ABB63349">
        <property type="protein sequence ID" value="ABB63349"/>
        <property type="gene ID" value="SDY_3358"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3358"/>
    <dbReference type="HOGENOM" id="CLU_008023_0_3_6"/>
    <dbReference type="OMA" id="FSIDTYH"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="30"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="297" mass="32318" checksum="7C66E9271E2CFDF4" modified="2005-12-06" version="1">MLRGFFLSIHTRDNIMKLFAQGTSLDLSHPHVMGILNVTPDSFSDGGTHNSLIDAVKHANLMINAGATIIDVGGESTRPGAAEVSVEEELQRVIPVVEAIAQRFEVWISVDTSKPEVIRESAKVGAHIINDIRSLSEPGALEAAAETGLPVCLMHMQGNPKTMQEAPKYDDVFAEVNRYFIEQIARCEQAGIAKEKLLLDPGFGFGKNLSHNYSLLARLAEFHHFNLPLLVGMSRKSMIGQLLNVGPSERLSGSLACAVIAAMQGAHIIGVHDVKETVEAMRVVEATLSAKENKRYE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BG5</accession>
    <name>IF2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infB</name>
        <name type="ordered locus">SDY_3347</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000133057.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404831.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BG5"/>
    <dbReference type="SMR" id="Q32BG5"/>
    <dbReference type="STRING" id="300267.SDY_3347"/>
    <dbReference type="EnsemblBacteria" id="ABB63340">
        <property type="protein sequence ID" value="ABB63340"/>
        <property type="gene ID" value="SDY_3347"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3347"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4001"/>
    <dbReference type="HOGENOM" id="CLU_006301_6_3_6"/>
    <dbReference type="OMA" id="NRDNRTG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013575">
        <property type="entry name" value="IF2_assoc_dom_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08364">
        <property type="entry name" value="IF2_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000228242" description="Translation initiation factor IF-2">
        <location>
            <begin position="1"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="389"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="398"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="423"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="444"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="498"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="534"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="398"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="444"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="498"/>
            <end position="501"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="890" mass="97380" checksum="10F851BB97298401" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BZ7</accession>
    <name>Q32BZ7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase</fullName>
            <ecNumber evidence="4">2.7.1.197</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">cmtA</name>
        <name evidence="18" type="ordered locus">SDY_3144</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannitol 1-phosphate(in) + L-histidyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:33363"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:16899"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.1.197"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.197" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000428788.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404649.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BZ7"/>
    <dbReference type="STRING" id="300267.SDY_3144"/>
    <dbReference type="EnsemblBacteria" id="ABB63158">
        <property type="protein sequence ID" value="ABB63158"/>
        <property type="gene ID" value="SDY_3144"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3144"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3755"/>
    <dbReference type="HOGENOM" id="CLU_028721_2_0_6"/>
    <dbReference type="OMA" id="FVAFACD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022872">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05567">
        <property type="entry name" value="PTS_IIB_mannitol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029503">
        <property type="entry name" value="PTS_EIIB_mannitol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004718">
        <property type="entry name" value="PTS_IIC_mtl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00851">
        <property type="entry name" value="mtlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="17">
        <location>
            <begin position="13"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="16">
        <location>
            <begin position="371"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB63158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="462" mass="48952" checksum="5537A6CF2C6BFBEB" modified="2005-12-06" version="1">MENKSARAKVQAFGGFLTAMVIPNIGAFIAWGFITALFIPTGWLPNEHFAKIVGPMITYLLPVMIGSTGGHLVGGKRGAVMGGIGTIGVIVGAEIPMFLGSMIMGPLGGLVIKYVDKALEKHIPAGFEMVINNFSLGIAGMLLCLLGFEVIGPAVLIANTFVKECIEALVHAGYLPLLSVINEPAKVLFLNNAIDQGVYYPLGMQQASVNGKSIFFMVASNPGPGLGLLLAFTLFGKGMSKRSAPGAMIIHFLGGIHELYFPYVLMKPLTIIAMIAGGMSGTWMFNLLDGGLVAGPSPGSIFAYLALTPKGSFLATIAGVTVGTLVSFAITSLILKMEKTVETESEDEFAQSANAVKAMKQEGAFSLSRVKRIAFVCDAGMGSSAMGATTFRKRLEKAGLAIEVKHYAIENVPADADIVVTHASLEGRVKRVTDKPLILINNYIGDPKLDTLFNQLTAEHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C24</accession>
    <name>Q32C24_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yggW</name>
        <name evidence="13" type="ordered locus">SDY_3117</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000239935.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404622.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C24"/>
    <dbReference type="STRING" id="300267.SDY_3117"/>
    <dbReference type="EnsemblBacteria" id="ABB63131">
        <property type="protein sequence ID" value="ABB63131"/>
        <property type="gene ID" value="SDY_3117"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3117"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3727"/>
    <dbReference type="HOGENOM" id="CLU_027579_2_1_6"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="378" mass="42468" checksum="44B96068CE583473" modified="2005-12-06" version="1">MVKLPPLSLYIHIPWCVQKCPYCDFNSHALKGEVPHDDYVQHLLNDLDNDVAHAQGREVKTIFIGGGTPSLLSGPAMQTLLDGVRARLPLAADAEITMEANPGTVEADRFVDYQRAGVNRISIGVQSFSEEKLKRLGRIHGPQEAKRAAKLASGLGLRSFNLDLMHGLPDQSLEEALGDLRQAIELNPPHLSWYQLTIEPNTLFGSRPPVLPDDDALWDIFEQGHQLLTAAGYQQYETSAYAKPGYQCQHNLNYWRFGDYIGIGCGAHGKVTFPDGRILRTTKTRHPRGFMQGRYLESQRDVEAADKPFEFFMNRFRLLEAAPRVEFSAYTGLCEDVIRPQLDEAIAQGYLTECADYWQITEHGKLLLNSLLELFLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CD3</accession>
    <name>Q32CD3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable PemK-like growth inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">chpA</name>
        <name evidence="1" type="ordered locus">SDY_2999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000254738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404513.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CD3"/>
    <dbReference type="SMR" id="Q32CD3"/>
    <dbReference type="STRING" id="300267.SDY_2999"/>
    <dbReference type="EnsemblBacteria" id="ABB63022">
        <property type="protein sequence ID" value="ABB63022"/>
        <property type="gene ID" value="SDY_2999"/>
    </dbReference>
    <dbReference type="GeneID" id="58459985"/>
    <dbReference type="KEGG" id="sdy:SDY_2999"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3598"/>
    <dbReference type="HOGENOM" id="CLU_121823_2_3_6"/>
    <dbReference type="OMA" id="QIKGYPF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="111" mass="12098" checksum="1579C867DD6B96AC" modified="2005-12-06" version="1">MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CE0</accession>
    <name>Q32CE0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_2992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001217989.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404506.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CE0"/>
    <dbReference type="STRING" id="300267.SDY_2992"/>
    <dbReference type="EnsemblBacteria" id="ABB63015">
        <property type="protein sequence ID" value="ABB63015"/>
        <property type="gene ID" value="SDY_2992"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2992"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3591"/>
    <dbReference type="HOGENOM" id="CLU_061138_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220762" description="TPM_phosphatase domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="236" mass="26754" checksum="1DE4751CCCBD4068" modified="2005-12-06" version="1">MRIFLLLLMLCGFQVFAERLPSVTDLTGTLTTEEQTALTQQLQTLEQQNHFLVAVLVTPTTGGKNIKLAASLRYGVYHWKPVGEKRYGEGILILVVWPEGLASMKIGHGLEEMLPPEQAAQIVRYHMQPEFEKNNLFAGLTGGIESIAQFTHIKANLSPLDALANHLFANPQRSLPCLAWTLLMIVAIVVLWRFASRPRRGIWMISMITPMVWFFSFQDDVIIRRVSVVWVMTLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CF0</accession>
    <name>Q32CF0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CF0"/>
    <dbReference type="EnsemblBacteria" id="ABB63005">
        <property type="protein sequence ID" value="ABB63005"/>
        <property type="gene ID" value="SDY_2982"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2982"/>
    <dbReference type="HOGENOM" id="CLU_162059_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9789" checksum="9F80CD9A9698244E" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITNILSMFKSLLINSLKHNTLLHFILYDLIHFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CX8</accession>
    <name>Q32CX8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ffh</name>
        <name evidence="9" type="ordered locus">SDY_2784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000460041.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404318.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CX8"/>
    <dbReference type="STRING" id="300267.SDY_2784"/>
    <dbReference type="EnsemblBacteria" id="ABB62827">
        <property type="protein sequence ID" value="ABB62827"/>
        <property type="gene ID" value="SDY_2784"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2784"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3355"/>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_6"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="248"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="453" mass="49753" checksum="40DF57463F70FDE3" modified="2005-12-06" version="1">MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQRPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEALPLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLASKLKKGDGFDLNDFLEQLLQMKNMGGMASLMGKLPGMGQIPDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D64</accession>
    <name>Q32D64_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D64"/>
    <dbReference type="EnsemblBacteria" id="ABB62741">
        <property type="protein sequence ID" value="ABB62741"/>
        <property type="gene ID" value="SDY_2694"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2694"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="89" mass="9812" checksum="09939C25850F132C" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITVAFSFIDAQQNPPHPEGGVFRQASHLTSNDDYSSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DE1</accession>
    <name>ZIPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein ZipA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">zipA</name>
        <name type="ordered locus">SDY_2609</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with FtsZ via their C-terminal domains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes to the Z ring in an FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZipA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001299866.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404155.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DE1"/>
    <dbReference type="SMR" id="Q32DE1"/>
    <dbReference type="STRING" id="300267.SDY_2609"/>
    <dbReference type="EnsemblBacteria" id="ABB62664">
        <property type="protein sequence ID" value="ABB62664"/>
        <property type="gene ID" value="SDY_2609"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2609"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3146"/>
    <dbReference type="HOGENOM" id="CLU_030174_1_0_6"/>
    <dbReference type="OMA" id="FWSIRKQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00231">
        <property type="entry name" value="ZipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00509">
        <property type="entry name" value="ZipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011919">
        <property type="entry name" value="Cell_div_ZipA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007449">
        <property type="entry name" value="ZipA_FtsZ-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036765">
        <property type="entry name" value="ZipA_FtsZ-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38685">
        <property type="entry name" value="PTHR38685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04354">
        <property type="entry name" value="ZipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00771">
        <property type="entry name" value="ZipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64383">
        <property type="entry name" value="SSF64383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02205">
        <property type="entry name" value="septum_zipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000237136" description="Cell division protein ZipA">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="6"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="28"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="332" mass="36947" checksum="6718C9C75C5476D2" modified="2005-12-06" version="1">MMQDLRLILIIVGAIAIIALLVHGFWTSRKERSSMFRDRPLKRMKSKRDDDSYDEDVEDDEGVGEVRVHRVNHAPANAQEHEAARPSPQHQYQPPYASAQPRQPVQQPPEAQVPPQHAPRPAQPVQQPVQQPAYQPQPEQPLQQPVSPQVAPAPQPVHSAPQPAQQAFQPAEPVAAPQPEPVAEPAPVMDKPKRKEAVIIMNVAAHHGSELNGELLLNSIQQAGFIFGDMNIYHRHLSPDGSGPALFSLANMVKPGTFDPEMKDFTTPGVTIFMQVPSYGDELQNFKLMLQSAQHIADEVGGVVLDDQRRMMTPQKLREYQDIIREVKDANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DE3</accession>
    <name>Q32DE3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Z3676 gene product</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000410201.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404153.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DE3"/>
    <dbReference type="SMR" id="Q32DE3"/>
    <dbReference type="STRING" id="300267.SDY_2607"/>
    <dbReference type="EnsemblBacteria" id="ABB62662">
        <property type="protein sequence ID" value="ABB62662"/>
        <property type="gene ID" value="SDY_2607"/>
    </dbReference>
    <dbReference type="GeneID" id="67416810"/>
    <dbReference type="KEGG" id="sdy:SDY_2607"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3144"/>
    <dbReference type="HOGENOM" id="CLU_176025_0_0_6"/>
    <dbReference type="OMA" id="MPFGKYE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024530">
        <property type="entry name" value="QSregVF_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40613">
        <property type="entry name" value="PTHR40613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12843">
        <property type="entry name" value="QSregVF_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8415" checksum="EB48248AAE37AB8C" modified="2005-12-06" version="1">MEKEQLIEIANTIMPFGKYKGRRLIDLPEEYLLWFARKDEFPAGKLGELMQITLLIKTEGLTQLVQPLKRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DQ5</accession>
    <name>Q32DQ5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-quinone oxidoreductase subunit F</fullName>
            <ecNumber evidence="12">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nuoF</name>
        <name evidence="14" type="ordered locus">SDY_2480</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000789500.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404041.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DQ5"/>
    <dbReference type="SMR" id="Q32DQ5"/>
    <dbReference type="STRING" id="300267.SDY_2480"/>
    <dbReference type="EnsemblBacteria" id="ABB62550">
        <property type="protein sequence ID" value="ABB62550"/>
        <property type="gene ID" value="SDY_2480"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2480"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2991"/>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_6"/>
    <dbReference type="OMA" id="CDDVIMD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 12" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0874">Quinone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="13">
        <location>
            <begin position="336"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB62550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="445" mass="49292" checksum="7F39A7DBE50C2075" modified="2005-12-06" version="1">MKNIIRTPETHPLTWRLRDDKQPVWLDEYRSKNGYEGARKALTGLSPDEIVNQVKDAGLKGRGGAGFSTGLKWSLMPKDESMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISAFALKAYRGYIFLRGEYIEAAVNLRRAIAEATEAGLLGKNIMGTGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPATSGAWGKPTCVNNVETLCNVPAILANGVEWYQNISKSKDAGTKLMGFSGRVKNPGLWELPFGTTAREILEDYAGGMRDGLKFKAWQPGGAGTDFLTEAHLDLPMEFESIGKAGSRLGTALAMAVDHEINMVSLVRNLEEFFARESCGWCTPCRDGLPWSVKILRALERGEGQPGDIETLEQLCRFLGPGKTFCAHAPGAVEPLQSAIKYFREEFEAGIKQPFSNTHLINGIQPNLLKERW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DQ8</accession>
    <name>NUOI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoI</name>
        <name type="ordered locus">SDY_2477</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000172752.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404038.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DQ8"/>
    <dbReference type="SMR" id="Q32DQ8"/>
    <dbReference type="STRING" id="300267.SDY_2477"/>
    <dbReference type="EnsemblBacteria" id="ABB62547">
        <property type="protein sequence ID" value="ABB62547"/>
        <property type="gene ID" value="SDY_2477"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2477"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2988"/>
    <dbReference type="HOGENOM" id="CLU_067218_4_3_6"/>
    <dbReference type="OMA" id="RGDLYYT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000245747" description="NADH-quinone oxidoreductase subunit I">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 1" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 2" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <sequence length="180" mass="20568" checksum="131871513999ACC7" modified="2005-12-06" version="1">MTLKELLVGFGTQVRSIWMIGLHAFAKRETRMYPEEPVYLPPRYRGRIVLTRDPDGEERCVACNLCAVACPVGCISLQKTETKDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFEMGEYKRQDLVYEKEDLLISGPGKYPEYNFYRMAGMAIDGKDKGEAENEAKPIDVKSLLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DT2</accession>
    <name>ARND_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD</fullName>
            <ecNumber evidence="1">3.5.1.n3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">arnD</name>
        <name type="ordered locus">SDY_2452</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate</text>
            <dbReference type="Rhea" id="RHEA:27734"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58909"/>
            <dbReference type="ChEBI" id="CHEBI:60463"/>
            <dbReference type="EC" id="3.5.1.n3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.n3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000169752.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404014.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DT2"/>
    <dbReference type="SMR" id="Q32DT2"/>
    <dbReference type="STRING" id="300267.SDY_2452"/>
    <dbReference type="EnsemblBacteria" id="ABB62523">
        <property type="protein sequence ID" value="ABB62523"/>
        <property type="gene ID" value="SDY_2452"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2452"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2958"/>
    <dbReference type="HOGENOM" id="CLU_084199_0_0_6"/>
    <dbReference type="OMA" id="KFLWKML"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00036">
        <property type="reaction ID" value="UER00496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036108">
        <property type="term" value="P:4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01870">
        <property type="entry name" value="ArnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023557">
        <property type="entry name" value="ArnD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383544" description="Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01870"/>
        </source>
    </evidence>
    <sequence length="296" mass="33114" checksum="720F38FE6DCCE431" modified="2005-12-06" version="1">MTKVGLRIDVDTFRGTREGVPRLLEILSKHNIQASIFFSVSPDNMGRHLWRLVKPQFLWKMLRSNAASLYGWDILLAGTAWLGKEIGHANADIIREAAKHHEVGLHAWDHHAWQARSGNWDRQTMIDDIARGLRTLEEIIGQPVTCSAAAGWRADQQVIEAKEAFHLRYNSDCRGAMPFRPLLESGNPGTAQIPVTLPTWDEVIGRDVKAEDFNGWLLNRILRDKGTPVYTIHAEVEGCAYQHNFVALLKRAAQEGVTFCPLSELLSETLPLGQVVRGNIAGREGWLGCQQIAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DY2</accession>
    <name>Q32DY2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DY2"/>
    <dbReference type="EnsemblBacteria" id="ABB62473">
        <property type="protein sequence ID" value="ABB62473"/>
        <property type="gene ID" value="SDY_2399"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2399"/>
    <dbReference type="HOGENOM" id="CLU_1365419_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="200" mass="22874" checksum="CE54C904C12FDC2B" modified="2005-12-06" version="1">MFNLFPEMHSSHYNDICSVSVDMTKGTQCMIHLMVNEEVFMSLPVPVATMVREDASNLVNLKTLLNDGCFIKYSHFNDVALIKQNINNLHLSHTVVNESILKKCCFENGSLGDVKITNSNVINSVFKNISFRSVKINNVNTHSLKFINCHFFNVDMIRVNFSKCLFHDCSMHGVGNDSNLLIVFYVQIMPDDFVMQLHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EH0</accession>
    <name>Q32EH0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001014550.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403776.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EH0"/>
    <dbReference type="EnsemblBacteria" id="ABB62285">
        <property type="protein sequence ID" value="ABB62285"/>
        <property type="gene ID" value="SDY_2200"/>
    </dbReference>
    <dbReference type="GeneID" id="60900878"/>
    <dbReference type="KEGG" id="sdy:SDY_2200"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2660"/>
    <dbReference type="HOGENOM" id="CLU_2698775_0_0_6"/>
    <dbReference type="OMA" id="IYCLHAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="73" mass="8491" checksum="190A2B45EF0F1C02" modified="2005-12-06" version="1">MNGTAFDLTYSEYNGAAARDADGIYRVMYVAKFEEAVYVLHCFQKKTQTTSQSDIDLAKRRYKELVQERKNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ET3</accession>
    <name>Q32ET3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Flagella basal body P-ring formation protein FlgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">flgA</name>
        <name evidence="9" type="ordered locus">SDY_2080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FlgA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000879694.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403663.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ET3"/>
    <dbReference type="STRING" id="300267.SDY_2080"/>
    <dbReference type="EnsemblBacteria" id="ABB62172">
        <property type="protein sequence ID" value="ABB62172"/>
        <property type="gene ID" value="SDY_2080"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2080"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2501"/>
    <dbReference type="HOGENOM" id="CLU_070510_2_0_6"/>
    <dbReference type="OMA" id="RYEIQVN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017585">
        <property type="entry name" value="Flag_basal_body_FlgA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039246">
        <property type="entry name" value="Flagellar_FlgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36307">
        <property type="entry name" value="PTHR36307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13144">
        <property type="entry name" value="ChapFlgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03170">
        <property type="entry name" value="flgA_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0574">Periplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005143092" description="Flagella basal body P-ring formation protein FlgA" evidence="7">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="8">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="23349" checksum="E763A217E2914C51" modified="2005-12-06" version="1">MLAIKRSVAIIAILFSPLSAASNLTSQLHTFFSSPLAGISDEVRVSIRTAPNLLPPCEQPLLSMSNNSRLWGNVNVLARCGNDKRYLQVNVQATGNYVVAAMPIVRGGKLGAGNVKLKRGRLDTLPPRTVLDINQLVDAVSLRDPSPDQSIQLTQFRQAWRVKAGQRVNVIASGDGFSANAEGQALNNAAVAQNARVRMVSGQVVSGVVDADGNILINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F24</accession>
    <name>Q32F24_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403572.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F24"/>
    <dbReference type="STRING" id="300267.SDY_1981"/>
    <dbReference type="EnsemblBacteria" id="ABB62081">
        <property type="protein sequence ID" value="ABB62081"/>
        <property type="gene ID" value="SDY_1981"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1981"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2391"/>
    <dbReference type="HOGENOM" id="CLU_151212_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="106" mass="12057" checksum="A5853E97D4217DA2" modified="2005-12-06" version="1">MALNTPQITPTKKITVRAIGEELPRGDYQRCPQCDMLFSLPEINSHQSAYCPRCQAKIRDGRDWSLTRLAAMAFTMLLLMPFAWGEPLLHIWLLGIRIDANVMQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F63</accession>
    <name>Q32F63_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pspD</name>
        <name evidence="1" type="ordered locus">SDY_1937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295585.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403533.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F63"/>
    <dbReference type="STRING" id="300267.SDY_1937"/>
    <dbReference type="EnsemblBacteria" id="ABB62042">
        <property type="protein sequence ID" value="ABB62042"/>
        <property type="gene ID" value="SDY_1937"/>
    </dbReference>
    <dbReference type="GeneID" id="67417367"/>
    <dbReference type="KEGG" id="sdy:SDY_1937"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2336"/>
    <dbReference type="HOGENOM" id="CLU_182267_0_0_6"/>
    <dbReference type="OMA" id="RTAAFRH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014321">
        <property type="entry name" value="Phageshock_PspD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09584">
        <property type="entry name" value="Phageshock_PspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02979">
        <property type="entry name" value="phageshock_pspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="73" mass="8042" checksum="F0B7317F3AEFD687" modified="2005-12-06" version="1">MNTRWQQAGQKVKPGFKLAGKLVLLTALRYGPAGVAGWAIKSVARRPLKMLLAVALEPLLSRAANKLAQRYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FB1</accession>
    <name>Q32FB1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ydhC</name>
        <name evidence="10" type="ordered locus">SDY_1886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001182366.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403485.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FB1"/>
    <dbReference type="STRING" id="300267.SDY_1886"/>
    <dbReference type="EnsemblBacteria" id="ABB61994">
        <property type="protein sequence ID" value="ABB61994"/>
        <property type="gene ID" value="SDY_1886"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1886"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2269"/>
    <dbReference type="HOGENOM" id="CLU_001265_47_1_6"/>
    <dbReference type="OMA" id="FNIICVV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="7"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="403" mass="43425" checksum="0A1C3051CD54D1F3" modified="2005-12-06" version="1">MQPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFATIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVIGLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIVTWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGYMMQRCKEVGCQNHGNAEVAHSESH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FD3</accession>
    <name>ANMK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
            <ecNumber evidence="1">2.7.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AnhMurNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">anmK</name>
        <name type="ordered locus">SDY_1863</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:24952"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58690"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.170"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anhydro-N-acetylmuramic acid kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.170" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000835077.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403463.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FD3"/>
    <dbReference type="SMR" id="Q32FD3"/>
    <dbReference type="STRING" id="300267.SDY_1863"/>
    <dbReference type="EnsemblBacteria" id="ABB61972">
        <property type="protein sequence ID" value="ABB61972"/>
        <property type="gene ID" value="SDY_1863"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1863"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2242"/>
    <dbReference type="HOGENOM" id="CLU_038782_0_0_6"/>
    <dbReference type="OMA" id="GQTIRHE"/>
    <dbReference type="UniPathway" id="UPA00343"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097175">
        <property type="term" value="P:1,6-anhydro-N-acetyl-beta-muramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01270">
        <property type="entry name" value="AnhMurNAc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="PTHR30605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000250059" description="Anhydro-N-acetylmuramic acid kinase">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01270"/>
        </source>
    </evidence>
    <sequence length="369" mass="39524" checksum="0D03AAC1815CF7A3" modified="2005-12-06" version="1">MKSGRFIGVMSGTSLDGVDVVLATIDEHRVAQLASLSWPIPVSLKQAVLDICQGQQLTLSQFGQLDTQLGRLFADAVNALLKEQNLQARDIVAIGCHGQTVWHEPTGVAPHTLQIGDNNQIVARTGITVVGDFRRRDIALGGQGAPLVPAFHHALLAHPTERRMVLNIGGIANLSLLIPGQPVGGYDTGPGNMLMDAWIWRQAGKPYDKDAEWARAGKVILPLLQNMLSDPYFSQPAPKSTGREYFNYGWLERHLRHFPGVDPRDVQATLAELTAVTISEQVLLSGGCERLMVCGGGSRNPLLMARLAALLPGTEVTTTDAVGISGDDMEALAFAWLAWRTLAGLPGNLPSVTGASQETVLGAIFPANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FH3</accession>
    <name>Q32FH3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FH3"/>
    <dbReference type="STRING" id="300267.SDY_1821"/>
    <dbReference type="EnsemblBacteria" id="ABB61932">
        <property type="protein sequence ID" value="ABB61932"/>
        <property type="gene ID" value="SDY_1821"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1821"/>
    <dbReference type="HOGENOM" id="CLU_097802_2_1_6"/>
    <dbReference type="OMA" id="GHRGMTH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016956">
        <property type="entry name" value="YdjM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030780">
        <property type="entry name" value="Md_memb_hyd_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="200" mass="22859" checksum="CE33DCD540CEAD4B" modified="2005-12-06" version="1">MSFIMTAEGHLLFSIACAVFAKNAELTPVLAQGDWWHIVPSAILTCLLPDIDHPKSFLGQRLKWISKPIARAFGHRGFTHSLLAVFALLATFYLKVPESWFIPADALQGMVLGYLSHILADMLTPAGVPLLWPCRWRFRLPILVPQKGNQLERFICMALFVWSVWMPHSLPENSAVRWSSQMINTLQIQFHRLIKHQVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FJ2</accession>
    <name>Q32FJ2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378745.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403404.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FJ2"/>
    <dbReference type="STRING" id="300267.SDY_1802"/>
    <dbReference type="EnsemblBacteria" id="ABB61913">
        <property type="protein sequence ID" value="ABB61913"/>
        <property type="gene ID" value="SDY_1802"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1802"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2174"/>
    <dbReference type="HOGENOM" id="CLU_089254_1_1_6"/>
    <dbReference type="OMA" id="SFEPFMR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="14"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27078" checksum="2AD8F7F4B1BB5F07" modified="2005-12-06" version="1">MKIFLENLYHSDCYFLPIRDNQQVLVGVELITHFSSEDGTVRIPTSRVIAQLTEEQHWQLFSEQLELLKSCQHFFIQHKLFAWLNLTPQVATLLLDRDNYAGELLKYPFIELLINENYPHLNEGKDNRGLLSLSQVYPLVLGNLGAGNSTMKAVFDGLFTRVMLDKSFIQQQIMHRSFELFIRAIQAQISPCCNCIIAGGIDTAEILAQITPFDFHALQGCLWPAVPINQITTLVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FP2</accession>
    <name>Q32FP2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403354.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FP2"/>
    <dbReference type="STRING" id="300267.SDY_1746"/>
    <dbReference type="EnsemblBacteria" id="ABB61863">
        <property type="protein sequence ID" value="ABB61863"/>
        <property type="gene ID" value="SDY_1746"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1746"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2105"/>
    <dbReference type="HOGENOM" id="CLU_153088_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021747">
        <property type="entry name" value="DUF3313"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11769">
        <property type="entry name" value="DUF3313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220699" evidence="1">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="112" mass="12326" checksum="84E56E832496D642" modified="2005-12-06" version="1">MRTTSFAKVAALCGLLALSGCASKITQPDKYSGFLNNYSDLKETTSATGKPVLRWLDPSFDQSKYDSIVWNPITYYPVPKPSTQVGQKVLDKILNYTNTEMKEAGDAANLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G06</accession>
    <name>Q32G06_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase</fullName>
            <ecNumber evidence="1">5.3.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Autoinducer 2-degrading protein LsrG</fullName>
            <shortName evidence="1">AI-2-degrading protein LsrG</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phospho-AI-2 isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lsrG</name>
        <name evidence="3" type="ordered locus">SDY_1624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5-phosphonooxypentane-2,4-dione (P-HPD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:44360"/>
            <dbReference type="ChEBI" id="CHEBI:71677"/>
            <dbReference type="ChEBI" id="CHEBI:84359"/>
            <dbReference type="EC" id="5.3.1.32"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LsrG family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.32" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000558527.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403240.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G06"/>
    <dbReference type="SMR" id="Q32G06"/>
    <dbReference type="STRING" id="300267.SDY_1624"/>
    <dbReference type="EnsemblBacteria" id="ABB61749">
        <property type="protein sequence ID" value="ABB61749"/>
        <property type="gene ID" value="SDY_1624"/>
    </dbReference>
    <dbReference type="GeneID" id="58461895"/>
    <dbReference type="KEGG" id="sdy:SDY_1624"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1956"/>
    <dbReference type="HOGENOM" id="CLU_131496_3_0_6"/>
    <dbReference type="OMA" id="DTVAPMM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02051">
        <property type="entry name" value="LsrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033672">
        <property type="entry name" value="LsrG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="96" mass="11255" checksum="138099193F125EB8" modified="2005-12-06" version="1">MHVTLVEINVHEDKVDEFIEVFRQNHLGSVQEEGNLRFDVLQDPEVNSRFYIYEAYKDEDAVAFHKTTPHYKTCVAKLESLMTGPRKKRLFNGLMP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-03" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G46</accession>
    <name>YNFA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0060 membrane protein YnfA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ynfA</name>
        <name type="ordered locus">SDY_1577</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0060 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022787.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403200.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G46"/>
    <dbReference type="STRING" id="300267.SDY_1577"/>
    <dbReference type="EnsemblBacteria" id="ABB61709">
        <property type="protein sequence ID" value="ABB61709"/>
        <property type="gene ID" value="SDY_1577"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1577"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1893"/>
    <dbReference type="HOGENOM" id="CLU_117653_2_1_6"/>
    <dbReference type="OMA" id="WLWAVEG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00010">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003844">
        <property type="entry name" value="UPF0060"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36116">
        <property type="entry name" value="PTHR36116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02694">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000282265" description="UPF0060 membrane protein YnfA">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="5"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="27"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="52"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00010"/>
        </source>
    </evidence>
    <sequence length="108" mass="11934" checksum="162690139422D1AF" modified="2005-12-06" version="1">MIKTTLLFFATALCEIIGCFLPWLWLKRNASIWLLLPAGISLALFVWLLTLHPAASGRIYAAYGGVYVCTALMWLRVVDGVKLTLYDWTGALIALCGMLIIVAGWGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G60</accession>
    <name>Q32G60_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ynfM</name>
        <name evidence="10" type="ordered locus">SDY_1559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G60"/>
    <dbReference type="STRING" id="300267.SDY_1559"/>
    <dbReference type="EnsemblBacteria" id="ABB61695">
        <property type="protein sequence ID" value="ABB61695"/>
        <property type="gene ID" value="SDY_1559"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1559"/>
    <dbReference type="HOGENOM" id="CLU_001265_19_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="33"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="357" mass="39036" checksum="A5184105289DD5C5" modified="2005-12-06" version="1">MSRTTTVDGAPASDTDKQSISQPNQFIKRGTPQFMRVTLALFSAGLATFALLYCVQPILPVLSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISGVFTDFFNWRIALAAIGCFALASALMFWKILPESRHFRPTSLRPKSLFINFRLHWRDRGLPLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQAVVGLLSLAYLTGTWSSPKAGTMTTRYGRGPVMLFSTGVMLFGLLMTLFSSLWLICRNVTLLSRILRSPLSCQQLDRPPCKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G64</accession>
    <name>Q32G64_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_1555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001260863.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403182.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G64"/>
    <dbReference type="STRING" id="300267.SDY_1555"/>
    <dbReference type="MEROPS" id="S01.260"/>
    <dbReference type="EnsemblBacteria" id="ABB61691">
        <property type="protein sequence ID" value="ABB61691"/>
        <property type="gene ID" value="SDY_1555"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1555"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1864"/>
    <dbReference type="HOGENOM" id="CLU_078170_0_0_6"/>
    <dbReference type="OMA" id="HQDCLIT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006993406" description="Serine protease" evidence="3">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="50"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="273" mass="29233" checksum="8CCC283B197581A8" modified="2005-12-06" version="1">MRTTIAVVLGAISLTSAFVFADKPDVAKSANNEVSTLFFDHDDRVPVNDTTQSPWDAVGQLETASGNLCTATLIAPNLALTAGHCLLTPPKGKADKAVALRFVSNKGLWRYDIHDIEGRVGPTLGKRLKADGDGWIVPPAAAPWDFGLIVLRNPPSGITPLPLFEGDKAALTAALKAAGRKVTQAGYPEDHLDTLYSHQNCEVTGWAQTSVMSHQCDTLPGDSGSPLMLHTNDGWQLIGVQSSAPAAKDRWRADNRAISVTGFRDKLDQLSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G85</accession>
    <name>Q32G85_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spy</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">spy</name>
        <name evidence="6" type="ordered locus">SDY_1534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpxP/Spy family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001228993.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403161.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G85"/>
    <dbReference type="STRING" id="300267.SDY_1534"/>
    <dbReference type="EnsemblBacteria" id="ABB61670">
        <property type="protein sequence ID" value="ABB61670"/>
        <property type="gene ID" value="SDY_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1534"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1838"/>
    <dbReference type="HOGENOM" id="CLU_124352_1_0_6"/>
    <dbReference type="OMA" id="HDMMFKD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09916">
        <property type="entry name" value="CpxP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012899">
        <property type="entry name" value="LTXXQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07813">
        <property type="entry name" value="LTXXQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034445">
        <property type="entry name" value="CpxP_Spy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220712" evidence="5">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="161" mass="18229" checksum="9966E6C544C5F9B9" modified="2005-12-06" version="1">MRKLTALFVASTLALGTANLAHAVDTTTAAPADAKPMMHHKGKFGPHQDMMFKDLNLTDAQKQQIREIMKGQRDQMKRPPLEERRAMHDIIASDTFDKAKAEAQIAKMEEQRKANMLAHMETQNKIYNILTPEQKKQFNANFEKRLTERPAAKGKMPATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GT7</accession>
    <name>Q32GT7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yciE</name>
        <name evidence="2" type="ordered locus">SDY_1321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402959.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GT7"/>
    <dbReference type="STRING" id="300267.SDY_1321"/>
    <dbReference type="EnsemblBacteria" id="ABB61468">
        <property type="protein sequence ID" value="ABB61468"/>
        <property type="gene ID" value="SDY_1321"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1321"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1568"/>
    <dbReference type="HOGENOM" id="CLU_093759_1_0_6"/>
    <dbReference type="OMA" id="HAMENQA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="1">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="169" mass="19059" checksum="8A1FD0CF9A7F480E" modified="2005-12-06" version="1">MPVHLKHYHDWLRDAHAMEKQAESMLESMASRIDNYPELRARIEQHLSETKNQIVQLETILDRNDISRSVIKDSMSKMAALGQSIGGIFPSDEIVKGSISGYVFEQFEIACYTSLLAAAKNAGDTASIPIIEAILNEEKQMADWLIQHIPQTTEKFLIRSETDGVEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GW9</accession>
    <name>Q32GW9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hns</name>
        <name evidence="9" type="ordered locus">SDY_1289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the histone-like protein H-NS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001287378.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402927.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GW9"/>
    <dbReference type="SMR" id="Q32GW9"/>
    <dbReference type="STRING" id="300267.SDY_1289"/>
    <dbReference type="EnsemblBacteria" id="ABB61436">
        <property type="protein sequence ID" value="ABB61436"/>
        <property type="gene ID" value="SDY_1289"/>
    </dbReference>
    <dbReference type="GeneID" id="66674941"/>
    <dbReference type="KEGG" id="sdy:SDY_1289"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1528"/>
    <dbReference type="HOGENOM" id="CLU_117503_0_0_6"/>
    <dbReference type="OMA" id="NGVEKTW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027444">
        <property type="entry name" value="H-NS_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037150">
        <property type="entry name" value="H-NS_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001801">
        <property type="entry name" value="Histone_HNS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027454">
        <property type="entry name" value="Histone_HNS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00816">
        <property type="entry name" value="Histone_HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002096">
        <property type="entry name" value="HnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00528">
        <property type="entry name" value="HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNS" evidence="8">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="6">
        <location>
            <begin position="112"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB61436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="137" mass="15540" checksum="E628184AC7C86F49" modified="2005-12-06" version="1">MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSLAAVKSGTKAKRAQRPAKYSYVDENGETKTWTGQGRTPAVIKKAMDEQGKSLDDFLIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GY7</accession>
    <name>Q32GY7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cation transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">chaB</name>
        <name evidence="1" type="ordered locus">SDY_1269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001146444.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402909.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GY7"/>
    <dbReference type="SMR" id="Q32GY7"/>
    <dbReference type="STRING" id="300267.SDY_1269"/>
    <dbReference type="EnsemblBacteria" id="ABB61418">
        <property type="protein sequence ID" value="ABB61418"/>
        <property type="gene ID" value="SDY_1269"/>
    </dbReference>
    <dbReference type="GeneID" id="58460423"/>
    <dbReference type="KEGG" id="sdy:SDY_1269"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1506"/>
    <dbReference type="HOGENOM" id="CLU_179907_0_0_6"/>
    <dbReference type="OMA" id="KAFNSAW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009317">
        <property type="entry name" value="ChaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037205">
        <property type="entry name" value="ChaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06150">
        <property type="entry name" value="ChaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140376">
        <property type="entry name" value="SSF140376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="76" mass="8945" checksum="6A3E56140D6E9FC1" modified="2005-12-06" version="1">MPYKTKSDLPESVKHVLPSHAQDIYKEAFNSAWDQYKDKEDRRDDASREETAHKVAWAAVKHEYAKGDDDKWHKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H00</accession>
    <name>Q32H00_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prsA</name>
        <name evidence="6" type="synonym">prs</name>
        <name evidence="8" type="ordered locus">SDY_1256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001298109.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402896.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H00"/>
    <dbReference type="SMR" id="Q32H00"/>
    <dbReference type="STRING" id="300267.SDY_1256"/>
    <dbReference type="EnsemblBacteria" id="ABB61405">
        <property type="protein sequence ID" value="ABB61405"/>
        <property type="gene ID" value="SDY_1256"/>
    </dbReference>
    <dbReference type="GeneID" id="67417475"/>
    <dbReference type="KEGG" id="sdy:SDY_1256"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1493"/>
    <dbReference type="HOGENOM" id="CLU_033546_2_0_6"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="96"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="315" mass="34218" checksum="4D69B7D118F93720" modified="2005-12-06" version="1">MPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQLNLDNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVLVDDMIDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAANNLRNSVIDEVVVCDTIPLSDEIKSLPNVRTLTLSGMLAEAIRRISNEESISAMFEH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H47</accession>
    <name>MINE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division topological specificity factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">minE</name>
        <name type="ordered locus">SDY_1205</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MinE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001185665.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402849.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H47"/>
    <dbReference type="SMR" id="Q32H47"/>
    <dbReference type="STRING" id="300267.SDY_1205"/>
    <dbReference type="EnsemblBacteria" id="ABB61358">
        <property type="protein sequence ID" value="ABB61358"/>
        <property type="gene ID" value="SDY_1205"/>
    </dbReference>
    <dbReference type="GeneID" id="67415436"/>
    <dbReference type="KEGG" id="sdy:SDY_1205"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1428"/>
    <dbReference type="HOGENOM" id="CLU_137929_2_2_6"/>
    <dbReference type="OMA" id="QIIVARE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1070.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00262">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005527">
        <property type="entry name" value="MinE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036707">
        <property type="entry name" value="MinE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03776">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55229">
        <property type="entry name" value="SSF55229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01215">
        <property type="entry name" value="minE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000298190" description="Cell division topological specificity factor">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00262"/>
        </source>
    </evidence>
    <sequence length="88" mass="10235" checksum="04DDFB4EA24F96C1" modified="2005-12-06" version="1">MALLDFFLSRKKNTANIAKERLQIIVAERRRSDAEPHYLPQLRKDILEVICKYVQIDPEMVTVQLEQKDGDISILELNVTLPEAEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H55</accession>
    <name>Q32H55_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402841.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H55"/>
    <dbReference type="STRING" id="300267.SDY_1197"/>
    <dbReference type="EnsemblBacteria" id="ABB61350">
        <property type="protein sequence ID" value="ABB61350"/>
        <property type="gene ID" value="SDY_1197"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1197"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1416"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="NKPNQKW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="256" mass="29724" checksum="82DF0AA268A9E82B" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQSGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAVLKKRTNGSVRYCQYTSVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HA8</accession>
    <name>Q32HA8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HA8"/>
    <dbReference type="STRING" id="300267.SDY_1140"/>
    <dbReference type="EnsemblBacteria" id="ABB61297">
        <property type="protein sequence ID" value="ABB61297"/>
        <property type="gene ID" value="SDY_1140"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1140"/>
    <dbReference type="HOGENOM" id="CLU_1647289_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="143" mass="16050" checksum="D435806FA40D21D0" modified="2005-12-06" version="1">MNKFFRFNVPVVYSDDIVLQRMSCMNCSDGDVVVLISHTGRTKNLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSRLAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKQLLNLSDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HF8</accession>
    <name>Q32HF8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yedK</name>
        <name evidence="8" type="ordered locus">SDY_1084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000334642.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HF8"/>
    <dbReference type="STRING" id="300267.SDY_1084"/>
    <dbReference type="EnsemblBacteria" id="ABB61247">
        <property type="protein sequence ID" value="ABB61247"/>
        <property type="gene ID" value="SDY_1084"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1084"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1274"/>
    <dbReference type="HOGENOM" id="CLU_035990_6_1_6"/>
    <dbReference type="OMA" id="FPARYNI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="223" mass="25061" checksum="673C24EC93F877AC" modified="2005-12-06" version="1">MCGRIAQSQTREDYLALLAEDIERDIPYDPEPIGRYNVAPGTKVLLLSERDEHLHLDPVFWGYAPGWWDKPPLINARVETAATSRMFKPLWQHGRAICFADGWFEWKKEGDKKQPFFIYRADGQPIFMAAIGSTPFERGDEAEGFLIVTAAADQGLVDIHDRRPLVLSPEAAREWMRQEISGKEASEIATNGCVPANQFTWHPVSRAVGNVKNQGAALIQPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HN7</accession>
    <name>Q32HN7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycdY</name>
        <name evidence="1" type="ordered locus">SDY_1002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001001927.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402659.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HN7"/>
    <dbReference type="STRING" id="300267.SDY_1002"/>
    <dbReference type="EnsemblBacteria" id="ABB61168">
        <property type="protein sequence ID" value="ABB61168"/>
        <property type="gene ID" value="SDY_1002"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1002"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1171"/>
    <dbReference type="HOGENOM" id="CLU_077650_7_2_6"/>
    <dbReference type="OMA" id="DEYLLPW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026269">
        <property type="entry name" value="DmsD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004690">
        <property type="entry name" value="DmsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="184" mass="20702" checksum="EAB32C6192DA4FBF" modified="2005-12-06" version="1">MNEFSILCRVLGSLYYRQPQDPLLVPLFTLIREGKLAANWPLEQDELLTRLQKSCDMVQVSADYNALFIGDECAVPPYRSAWVEGATEAEVHAFLSERGMPLADTPADHIGTLLLAASWLEDQSTEDESEALETLFSEYLLPWCGAFLGKVEAHATTPFWRTMAPLTRDAISAMWDELEENSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HP9</accession>
    <name>Q32HP9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tet operon regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycdC</name>
        <name evidence="3" type="ordered locus">SDY_0988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005020332.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402647.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HP9"/>
    <dbReference type="STRING" id="300267.SDY_0988"/>
    <dbReference type="EnsemblBacteria" id="ABB61156">
        <property type="protein sequence ID" value="ABB61156"/>
        <property type="gene ID" value="SDY_0988"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0988"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1149"/>
    <dbReference type="HOGENOM" id="CLU_069356_1_0_6"/>
    <dbReference type="OMA" id="DPHHLIF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019915">
        <property type="entry name" value="Tscrpt_reg_pyr_util_RutR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013573">
        <property type="entry name" value="Tscrpt_reg_YcdC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08362">
        <property type="entry name" value="TetR_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03613">
        <property type="entry name" value="RutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="212" mass="23715" checksum="5B5C81A71757E458" modified="2005-12-06" version="1">MTQGAVKTTGKRSRAVNAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLKAFREDFAPLAAIKEYIRLKLEVSRDYPQASRLFCMEMLAGAPLLMDELTGDLKALIDEKSALIAGWVKSGKLAPIDPQHLIFMIWASTQHYADFAPQVEAVTGATLRDEVFFNQTVENVQRIIIEGIRPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HQ0</accession>
    <name>RUTA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyrimidine monooxygenase RutA</fullName>
            <ecNumber evidence="1">1.14.99.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rutA</name>
        <name type="ordered locus">SDY_0987</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide. The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN. Requires the flavin reductase RutF to regenerate FMN in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>FMNH2 + NADH + O2 + uracil = (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:31587"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:59891"/>
            <dbReference type="EC" id="1.14.99.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>FMNH2 + NADH + O2 + thymine = (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:31599"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:143783"/>
            <dbReference type="EC" id="1.14.99.46"/>
        </reaction>
    </comment>
    <comment type="induction">
        <text evidence="1">Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.46" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402646.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HQ0"/>
    <dbReference type="SMR" id="Q32HQ0"/>
    <dbReference type="STRING" id="300267.SDY_0987"/>
    <dbReference type="EnsemblBacteria" id="ABB61155">
        <property type="protein sequence ID" value="ABB61155"/>
        <property type="gene ID" value="SDY_0987"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0987"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1148"/>
    <dbReference type="HOGENOM" id="CLU_027853_1_1_6"/>
    <dbReference type="OMA" id="ADYNFCF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052614">
        <property type="term" value="F:uracil oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01699">
        <property type="entry name" value="RutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019914">
        <property type="entry name" value="Pyrimidine_monooxygenase_RutA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03612">
        <property type="entry name" value="RutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000402639" description="Pyrimidine monooxygenase RutA">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01699"/>
        </source>
    </evidence>
    <sequence length="382" mass="42269" checksum="86F7AFC8846E4631" modified="2005-12-06" version="1">MQDAVPRLTFTLRDEERLMVKIGVFVPIGNNGWLISPHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGSGKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFGKGVNTPTAFAPTAVRMKQAAEQTGRDVGSYILFMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPSAEGVLLTFDDFLSGIETFGERIQPLMQCRAHLPVLTQEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HR1</accession>
    <name>Q32HR1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009000672.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HR1"/>
    <dbReference type="EnsemblBacteria" id="ABB61144">
        <property type="protein sequence ID" value="ABB61144"/>
        <property type="gene ID" value="SDY_0975"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0975"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1132"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="94" mass="10841" checksum="96D0F152FB906F11" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMLTSDDWGSYGREVPKDKHLTGKIFTQRVMTLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HR3</accession>
    <name>Q32HR3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yccD</name>
        <name evidence="1" type="ordered locus">SDY_0973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000024562.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402633.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HR3"/>
    <dbReference type="STRING" id="300267.SDY_0973"/>
    <dbReference type="EnsemblBacteria" id="ABB61142">
        <property type="protein sequence ID" value="ABB61142"/>
        <property type="gene ID" value="SDY_0973"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0973"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1128"/>
    <dbReference type="HOGENOM" id="CLU_144710_3_1_6"/>
    <dbReference type="OMA" id="YVIEIVE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="101" mass="11489" checksum="3F9C25C3577FDDB7" modified="2005-12-06" version="1">MANVTVTFTITEFCLHTGISEEELNEIVGLGVVEPREIQETTWVFDDHAAIVVQRAVRLRNELALDWPGIAVALTLMDDIAHLKQENRLLRQRLSRFVAHP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HT9</accession>
    <name>RLMI_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase I</fullName>
            <ecNumber evidence="1">2.1.1.191</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m5C1962 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-C(5)-)-methyltransferase RlmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmI</name>
        <name type="ordered locus">SDY_0942</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42912"/>
            <dbReference type="Rhea" id="RHEA-COMP:10382"/>
            <dbReference type="Rhea" id="RHEA-COMP:10386"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.191"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RlmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.191" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000116277.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402607.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HT9"/>
    <dbReference type="SMR" id="Q32HT9"/>
    <dbReference type="STRING" id="300267.SDY_0942"/>
    <dbReference type="EnsemblBacteria" id="ABB61116">
        <property type="protein sequence ID" value="ABB61116"/>
        <property type="gene ID" value="SDY_0942"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0942"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1090"/>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_6"/>
    <dbReference type="OMA" id="VMDVFDY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016434">
        <property type="term" value="F:rRNA (cytosine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01857">
        <property type="entry name" value="23SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023542">
        <property type="entry name" value="rRNA_lsu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000366268" description="Ribosomal RNA large subunit methyltransferase I">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01857"/>
        </source>
    </evidence>
    <sequence length="398" mass="44612" checksum="1080F8EBEB305733" modified="2005-12-06" version="1">MSVRLVLAKGREKSLLRRHPWVFSGAVARMEGKASLGETIDIVDHQGKWLARGAYSPASQIRARVWTFDLSESIDIAFFSRRLQQAQKWRDWLAQKDGLDSYRLIAGESDGLPGITIDRFGNFLVLQLLSAGAEYQRAALISALQTLYPECAIYDRSDVAVRKKEGMELTQGLVTGELPPALLPIEEHGMKLLVDIQHGHKTGYYLDQRDSRLATRRYVENKRVLNCFSYTGGFAVSALMGGCNQVVSVDTSQEALDIARQNVELNKLDLSKAEFVRDDVFKLLRTYRDRGEKFDVIVMDPPKFVENKSQLMGACRGYKDINMLAIQLLNEGGILLTFSCSGLMTSDLFQKIIADAAIDAGRDVQFIEQFRQAADHPVIATYPEGLYLKGFACRVIVM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-07" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I06</accession>
    <name>NAPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Periplasmic nitrate reductase</fullName>
            <ecNumber evidence="1">1.9.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">napA</name>
        <name type="ordered locus">SDY_0872</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 Fe(II)-[cytochrome] + 2 H(+) + nitrate = 2 Fe(III)-[cytochrome] + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:12909"/>
            <dbReference type="Rhea" id="RHEA-COMP:11777"/>
            <dbReference type="Rhea" id="RHEA-COMP:11778"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.9.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
        <text evidence="1">Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.9.6.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000778031.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402540.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I06"/>
    <dbReference type="SMR" id="Q32I06"/>
    <dbReference type="STRING" id="300267.SDY_0872"/>
    <dbReference type="EnsemblBacteria" id="ABB61049">
        <property type="protein sequence ID" value="ABB61049"/>
        <property type="gene ID" value="SDY_0872"/>
    </dbReference>
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                <person name="Yan Y."/>
                <person name="Tang X."/>
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        <property type="entry name" value="DUF4376"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14301">
        <property type="entry name" value="DUF4376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4376" evidence="1">
        <location>
            <begin position="73"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="184" mass="21024" checksum="A09C4E656F813D81" modified="2005-12-06" version="1">MKKEQMVVSAIASTPHDVFFDDRDQAVPYTATADDVASTGQQIWQELQSGKWGEIAPFTVTPEMLEAAREARRQEIEAWRTEQEAKPFTFEWNGRIWNAGPDSLGRLSPVVMLAKSVTAQTHMAWSDADNQQVKLSMPELEELAAAMVQAQVDRNDEIYRRQREMKEELNNLEDLHSIRAFDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I36</accession>
    <name>Q32I36_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402510.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I36"/>
    <dbReference type="STRING" id="300267.SDY_0839"/>
    <dbReference type="EnsemblBacteria" id="ABB61021">
        <property type="protein sequence ID" value="ABB61021"/>
        <property type="gene ID" value="SDY_0839"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0839"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.966"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="131" mass="15391" checksum="1214D51197512F77" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGVLAYTFGPRTDETCRELLALLTPFNIGMITSDDWGNYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I44</accession>
    <name>BIOB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin synthase</fullName>
            <ecNumber evidence="1">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bioB</name>
        <name type="ordered locus">SDY_0831</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000951215.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402502.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I44"/>
    <dbReference type="SMR" id="Q32I44"/>
    <dbReference type="STRING" id="300267.SDY_0831"/>
    <dbReference type="EnsemblBacteria" id="ABB61013">
        <property type="protein sequence ID" value="ABB61013"/>
        <property type="gene ID" value="SDY_0831"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0831"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.957"/>
    <dbReference type="HOGENOM" id="CLU_033172_1_2_6"/>
    <dbReference type="OMA" id="ADRFCMG"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0093">Biotin biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000381633" description="Biotin synthase">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="38"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="346" mass="38616" checksum="3FBD7899B69B3096" modified="2005-12-06" version="1">MAHRPRWTLSQVTELFEKPLLDLLFEAQQVHRQHFDPRQVQVSTLLSIKTGACPEDCKYCPQSSRYKTGLEAERLMEVEQVLESARKAKAAGSTRFCMGAAWKNPHERDMPYLEQMVQGVKAMGLEACMTLGTLSESQAQRLANAGLDYYNHNLDTSPEFYGNIITTRTYQERLDTLEKVRDAGIKVCSGGIVGLGETVKDRAGLLLQLANLPTPPESVPINMLVKVKGTPLADNDDVDAFDFIRTIAVARIMMPTSYVRLSAGREQMNEQTQAMCFVAGANSIFYGCKLLTTPNPEEDKDLQLFRKLGLNPQQTAVLAGDNEQQQRLEQALMTPDTDEYYNAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I51</accession>
    <name>Q32I51_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Molybdenum cofactor biosynthesis protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">moaB</name>
        <name evidence="7" type="ordered locus">SDY_0824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the biosynthesis of molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000084629.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402495.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I51"/>
    <dbReference type="STRING" id="300267.SDY_0824"/>
    <dbReference type="EnsemblBacteria" id="ABB61006">
        <property type="protein sequence ID" value="ABB61006"/>
        <property type="gene ID" value="SDY_0824"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0824"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.950"/>
    <dbReference type="HOGENOM" id="CLU_077358_2_2_6"/>
    <dbReference type="OMA" id="TGWDGIL"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013484">
        <property type="entry name" value="MoaB_proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006443">
        <property type="entry name" value="MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02667">
        <property type="entry name" value="moaB_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="6">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="170" mass="18679" checksum="DB3A21A7F3BE5E20" modified="2005-12-06" version="1">MSQVSTEFIPTRIAILTVSNRRGEEDDTSGHYLRDSAQEAGHHIVDKAIVKENRYAIRAQVSAWIASDDVQVVLITGGTGLTEGDQAPEALLPLFDREVEGFGEVFRMLSFEEIGTSTLQSRAVAGVANKTLIFAMPGSTKACRTAWENIIAPQLDARTRPCNFHPHLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IK8</accession>
    <name>Q32IK8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 19">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="8 19">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">sdhA</name>
        <name evidence="22" type="ordered locus">SDY_0661</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 19">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 19">Cell inner membrane</location>
            <topology evidence="5 19">Peripheral membrane protein</topology>
            <orientation evidence="5 19">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="8 19"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000775528.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402338.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IK8"/>
    <dbReference type="STRING" id="300267.SDY_0661"/>
    <dbReference type="EnsemblBacteria" id="ABB60849">
        <property type="protein sequence ID" value="ABB60849"/>
        <property type="gene ID" value="SDY_0661"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0661"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.772"/>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_6"/>
    <dbReference type="OMA" id="DPIPIQP"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 19" id="KW-0274">FAD</keyword>
    <keyword evidence="12 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-0813">Transport</keyword>
    <keyword evidence="11 19" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="20">
        <location>
            <begin position="9"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="21">
        <location>
            <begin position="460"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="18">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ABB60849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="588" mass="64438" checksum="FD5DB114ECACA954" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IR9</accession>
    <name>Q32IR9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate/aspartate transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gltK</name>
        <name evidence="11" type="ordered locus">SDY_0588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000272824.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402277.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IR9"/>
    <dbReference type="SMR" id="Q32IR9"/>
    <dbReference type="STRING" id="300267.SDY_0588"/>
    <dbReference type="EnsemblBacteria" id="ABB60788">
        <property type="protein sequence ID" value="ABB60788"/>
        <property type="gene ID" value="SDY_0588"/>
    </dbReference>
    <dbReference type="GeneID" id="66671073"/>
    <dbReference type="KEGG" id="sdy:SDY_0588"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.689"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_1_6"/>
    <dbReference type="OMA" id="WQSMKLV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030205">
        <property type="entry name" value="GltK/AatM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614:SF1">
        <property type="entry name" value="PTHR30614:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB60788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="224" mass="24915" checksum="01BCB38D387807B6" modified="2005-12-06" version="1">MYEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLGLSPKNDIRLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IU8</accession>
    <name>Q32IU8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dacA</name>
        <name evidence="17" type="ordered locus">SDY_0554</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001092082.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402248.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IU8"/>
    <dbReference type="SMR" id="Q32IU8"/>
    <dbReference type="STRING" id="300267.SDY_0554"/>
    <dbReference type="MEROPS" id="S11.008"/>
    <dbReference type="EnsemblBacteria" id="ABB60759">
        <property type="protein sequence ID" value="ABB60759"/>
        <property type="gene ID" value="SDY_0554"/>
    </dbReference>
    <dbReference type="GeneID" id="66671094"/>
    <dbReference type="KEGG" id="sdy:SDY_0554"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.655"/>
    <dbReference type="HOGENOM" id="CLU_027070_8_1_6"/>
    <dbReference type="OMA" id="QNTHFQT"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221155" description="Serine-type D-Ala-D-Ala carboxypeptidase" evidence="15">
        <location>
            <begin position="30"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="PBP5_C" evidence="16">
        <location>
            <begin position="292"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB60759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="403" mass="44444" checksum="7FAAB8E98452FF22" modified="2005-12-06" version="1">MNTIFSARIMKRLALTTALCTAFISAAHADDLNIKTMIPGVPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMKAGKFKETDLVTIGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADFAAGSQDAFVGLMNSYVNALGLKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYSIYKEKEFTFNGIRQLNRNGLLWDNSLNVDGIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGREAESKKLLTWGFRFFETVNPLKVGKEFASEPVWFGDSDRASLGVDKDVYLTIPRGRMKDLKASYVLNSSELHAPLQKNQVVGTINFQLDGKTIEQRPLVVLQEIPEGNFFGKIIDYIKLMFHHWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IX4</accession>
    <name>Q32IX4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase</fullName>
            <ecNumber evidence="3">3.3.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">entB</name>
        <name evidence="7" type="ordered locus">SDY_0526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + isochorismate = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11112"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58764"/>
            <dbReference type="EC" id="3.3.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
        <text evidence="4">Binds 1 phosphopantetheine covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001007154.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402222.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IX4"/>
    <dbReference type="STRING" id="300267.SDY_0526"/>
    <dbReference type="EnsemblBacteria" id="ABB60733">
        <property type="protein sequence ID" value="ABB60733"/>
        <property type="gene ID" value="SDY_0526"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0526"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.619"/>
    <dbReference type="HOGENOM" id="CLU_068979_2_0_6"/>
    <dbReference type="OMA" id="RDIKPFF"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008908">
        <property type="term" value="F:isochorismatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016291">
        <property type="entry name" value="Isochorismatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001111">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01398">
        <property type="entry name" value="ISCHRISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="209"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4 5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001111-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="285" mass="32544" checksum="A40CB9F4B967BAB3" modified="2005-12-06" version="1">MAIPKLQAYALPESHDITQNKVDWAFEPQRAALLIHDMQDYFVSFWGENCPMMEQVIANIAALRDYCKQHNIPVYYTAQPKEQSDEDRALLNDMWGPGLTRSPEQQKVVDRLTPDADDTVLVKWRYSAFHRSPLEQMLKESGRNQLIITGVYAHIGCMTTATDAFMRDIKPFMVADALADFSRDEHLMSLKYVAGRSGRVVMTEELLPAPIPASKAALREVILPLLDESDEPFDDDNLIDYGLDSVRMMALAARWRKVHGDIDFVMLGKNPTIDAWWKLLSREVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J63</accession>
    <name>Q32J63_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ybaR</name>
        <name evidence="10" type="ordered locus">SDY_0434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000083981.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402133.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J63"/>
    <dbReference type="STRING" id="300267.SDY_0434"/>
    <dbReference type="EnsemblBacteria" id="ABB60644">
        <property type="protein sequence ID" value="ABB60644"/>
        <property type="gene ID" value="SDY_0434"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0434"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.515"/>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_6"/>
    <dbReference type="OMA" id="ITFFGWM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB60644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="834" mass="88125" checksum="12D15E22DBD40E39" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JA3</accession>
    <name>Q32JA3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybaA</name>
        <name evidence="1" type="ordered locus">SDY_0392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000878140.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402093.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JA3"/>
    <dbReference type="SMR" id="Q32JA3"/>
    <dbReference type="STRING" id="300267.SDY_0392"/>
    <dbReference type="EnsemblBacteria" id="ABB60604">
        <property type="protein sequence ID" value="ABB60604"/>
        <property type="gene ID" value="SDY_0392"/>
    </dbReference>
    <dbReference type="GeneID" id="66671242"/>
    <dbReference type="KEGG" id="sdy:SDY_0392"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.465"/>
    <dbReference type="HOGENOM" id="CLU_136844_0_0_6"/>
    <dbReference type="OMA" id="YVECIGD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009874">
        <property type="entry name" value="DUF1428"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07237">
        <property type="entry name" value="DUF1428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007028">
        <property type="entry name" value="UCP007028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="117" mass="13318" checksum="5E320D62A2A93FF9" modified="2005-12-06" version="1">MKYVDGFVVAVPADKKDAYREMAAKAAPLFKEFGALRIVECWASDVPDGKVTDFRMAVKAEENEEVVFSWIEYPSKEVRDAANQKMMSDPRMKEFGESMPFDGKRMIYGGFESIIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JC7</accession>
    <name>Q32JC7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402069.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JC7"/>
    <dbReference type="STRING" id="300267.SDY_0366"/>
    <dbReference type="EnsemblBacteria" id="ABB60580">
        <property type="protein sequence ID" value="ABB60580"/>
        <property type="gene ID" value="SDY_0366"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0366"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.433"/>
    <dbReference type="HOGENOM" id="CLU_2119459_0_0_6"/>
    <dbReference type="OMA" id="LIFIMNG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020490">
        <property type="entry name" value="Uncharacterised_YaiZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10953">
        <property type="entry name" value="DUF2754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="114" mass="13020" checksum="FC5CF923A7A78965" modified="2005-12-06" version="1">MNLRCESQNGNFKLNLLTITKMLSTPQTVVTEYARMSFFVNGAAMNLPVKIRRDWHYYAFAIGLIFILNGVVGLLGFEAKGWQTYAVGLVTWVISFWLAGLIIRRRDEETENAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JI2</accession>
    <name>Q32JI2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-methyl-5(Beta-hydroxyethyl)-thiazole monophosphate synthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiJ</name>
        <name evidence="2" type="ordered locus">SDY_0306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402014.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JI2"/>
    <dbReference type="STRING" id="300267.SDY_0306"/>
    <dbReference type="EnsemblBacteria" id="ABB60525">
        <property type="protein sequence ID" value="ABB60525"/>
        <property type="gene ID" value="SDY_0306"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0306"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.351"/>
    <dbReference type="HOGENOM" id="CLU_000445_44_2_6"/>
    <dbReference type="OMA" id="TSYPAMK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="198" mass="21110" checksum="FFEE6FBA0228FC7D" modified="2005-12-06" version="1">MNMSVSALVCLAPGSEETEAVTTIDLLVRGGIKVTTVSVASDGNLAITCSRGVKLLADAPLVEVADGEYDVIVLPGGIKGAECFRDSTLLVETVKQFHRSGRIVAAICAAPATVLVPHDIFPIGNMTGFPTLKDKIPAEQWQDKRVVWDARVKLLTSQGLGTAIDFGLKIIDLLVGREKAHEVASQLVMAAGIYNYYE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JL2</accession>
    <name>LPXH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-2,3-diacylglucosamine hydrolase</fullName>
            <ecNumber evidence="1">3.6.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-2,3-diacylglucosamine diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxH</name>
        <name type="ordered locus">SDY_0276</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:25213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:57957"/>
            <dbReference type="ChEBI" id="CHEBI:78847"/>
            <dbReference type="EC" id="3.6.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 Mn(2+) ions per subunit in a binuclear metal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LpxH family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.54" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000212265.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401984.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JL2"/>
    <dbReference type="SMR" id="Q32JL2"/>
    <dbReference type="STRING" id="300267.SDY_0276"/>
    <dbReference type="EnsemblBacteria" id="ABB60495">
        <property type="protein sequence ID" value="ABB60495"/>
        <property type="gene ID" value="SDY_0276"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0276"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.316"/>
    <dbReference type="HOGENOM" id="CLU_074586_0_0_6"/>
    <dbReference type="OMA" id="FDFWFEY"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019897">
        <property type="term" value="C:extrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008758">
        <property type="term" value="F:UDP-2,3-diacylglucosamine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00575">
        <property type="entry name" value="LpxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010138">
        <property type="entry name" value="UDP-diacylglucosamine_Hdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990:SF1">
        <property type="entry name" value="PTHR34990:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01854">
        <property type="entry name" value="lipid_A_lpxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000025091" description="UDP-2,3-diacylglucosamine hydrolase">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00575"/>
        </source>
    </evidence>
    <sequence length="240" mass="26924" checksum="172A996FDFADC35C" modified="2005-12-06" version="1">MATLFIADLHLCVEEPAITAGFLRFLAGEARNADALYILGDLFEAWIGDDDPNPLHRQMAAAIKAVSDSGVPCYFIHGNRDFLLGKRFARESDMTLLPEEKVLELYGRRVLIMHGDTLCTDDAGYQAFRAKVHNPWLQTLFLALPLFVRKRIAARMRANSKEANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JN3</accession>
    <name>Q32JN3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yafQ</name>
        <name evidence="3" type="ordered locus">SDY_0251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000615980.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401963.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JN3"/>
    <dbReference type="STRING" id="300267.SDY_0251"/>
    <dbReference type="EnsemblBacteria" id="ABB60474">
        <property type="protein sequence ID" value="ABB60474"/>
        <property type="gene ID" value="SDY_0251"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0251"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.282"/>
    <dbReference type="HOGENOM" id="CLU_161929_4_1_6"/>
    <dbReference type="OMA" id="DHRECHV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004386">
        <property type="entry name" value="Toxin_YafQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40588">
        <property type="entry name" value="PTHR40588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15738">
        <property type="entry name" value="YafQ_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006156">
        <property type="entry name" value="YafQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00053">
        <property type="entry name" value="TIGR00053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="92" mass="10831" checksum="88D90151BD4B9297" modified="2005-12-06" version="1">MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLRFERTGTHAALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JV0</accession>
    <name>Q32JV0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vitamin B12-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yadT</name>
        <name evidence="1" type="synonym">btuF</name>
        <name evidence="3" type="ordered locus">SDY_0174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtuF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001311399.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401896.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JV0"/>
    <dbReference type="STRING" id="300267.SDY_0174"/>
    <dbReference type="EnsemblBacteria" id="ABB60407">
        <property type="protein sequence ID" value="ABB60407"/>
        <property type="gene ID" value="SDY_0174"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0174"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.200"/>
    <dbReference type="HOGENOM" id="CLU_038034_2_5_6"/>
    <dbReference type="OMA" id="WQGINLE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01000">
        <property type="entry name" value="BtuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023544">
        <property type="entry name" value="ABC_transptr_vit_B12-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019124" description="Vitamin B12-binding protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cyanocob(III)alamin-binding" evidence="1">
        <location>
            <begin position="242"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for BtuC binding" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="site" description="Important for BtuC binding" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="183"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="266" mass="29357" checksum="894608B9677BB785" modified="2005-12-06" version="1" precursor="true">MAKSLFRALVALSFLAPLWLNAAPRVITLSPANTELAFAAGITPVGVSSYSDYPPQAQKIEQVSTWQGMNLERIVALKPDLVIAWRGGNAERQVDQLASLGIKVMWVDATSIEQIANALRQLAPWSPQPDKAEQAAQSLLDQYAQLKAQYADKSKKRVFLQFGINPPFTSGKESIQNQVLEVCGGENIFKDSRVPWPQVSREQVLARSPQAIVITGGPDQIPKIKQYWGEQLKIPVIPLTSDWFERASPRIILAAQQLCNALSQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JV8</accession>
    <name>Q32JV8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Outer membrane protein receptor for ferrichrome, colicin M, and phages T1, T5, and phi80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fhuA</name>
        <name evidence="13" type="ordered locus">SDY_0166</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000124393.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401888.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JV8"/>
    <dbReference type="STRING" id="300267.SDY_0166"/>
    <dbReference type="EnsemblBacteria" id="ABB60399">
        <property type="protein sequence ID" value="ABB60399"/>
        <property type="gene ID" value="SDY_0166"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0166"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.192"/>
    <dbReference type="HOGENOM" id="CLU_008287_9_0_6"/>
    <dbReference type="OMA" id="FSWRPDD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220797" evidence="10">
        <location>
            <begin position="34"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="12">
        <location>
            <begin position="77"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="11">
        <location>
            <begin position="272"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB60399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="747" mass="82190" checksum="C614FC159C6FCACF" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JX2</accession>
    <name>Q32JX2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PapC_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401874.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JX2"/>
    <dbReference type="STRING" id="300267.SDY_0151"/>
    <dbReference type="EnsemblBacteria" id="ABB60385">
        <property type="protein sequence ID" value="ABB60385"/>
        <property type="gene ID" value="SDY_0151"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0151"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.170"/>
    <dbReference type="HOGENOM" id="CLU_009120_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015473">
        <property type="term" value="F:fimbrial usher porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000015">
        <property type="entry name" value="Fimb_usher"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042186">
        <property type="entry name" value="FimD_plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025949">
        <property type="entry name" value="PapC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043142">
        <property type="entry name" value="PapC-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30451">
        <property type="entry name" value="PTHR30451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13953">
        <property type="entry name" value="PapC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00577">
        <property type="entry name" value="Usher"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PapC_C" evidence="1">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="163" mass="18441" checksum="F5E4E0173EDCFC06" modified="2005-12-06" version="1">MKNTCSTNWKHHPDTFAILDAPGLEGAHINGQKYNRTNNKGQVVYDLMIPHRENHLVLDTANSESETELQGNRQIIAPYRGAVSYVQFTTDQRKRWYIQALRPDGSPLTFGYDVLDLQENNIGVVGQGSRLFIRVDEIPTGIKVALNDEQNLFCTITFQHVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JX9</accession>
    <name>Q32JX9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="4 10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">aceE</name>
        <name evidence="14" type="ordered locus">SDY_0144</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000003838.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401867.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JX9"/>
    <dbReference type="STRING" id="300267.SDY_0144"/>
    <dbReference type="EnsemblBacteria" id="ABB60378">
        <property type="protein sequence ID" value="ABB60378"/>
        <property type="gene ID" value="SDY_0144"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0144"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.162"/>
    <dbReference type="HOGENOM" id="CLU_009154_2_0_6"/>
    <dbReference type="OMA" id="PDEYRTF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="12">
        <location>
            <begin position="106"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="13">
        <location>
            <begin position="489"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB60378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="887" mass="99681" checksum="6E1C1EBE7609F4C4" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K18</accession>
    <name>Q32K18_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0016</name>
        <name evidence="4" type="ordered locus">SDY_0103</name>
        <name evidence="5" type="ordered locus">SDY_0413</name>
        <name evidence="6" type="ordered locus">SDY_0678</name>
        <name evidence="7" type="ordered locus">SDY_0700</name>
        <name evidence="8" type="ordered locus">SDY_1834</name>
        <name evidence="9" type="ordered locus">SDY_2284</name>
        <name evidence="10" type="ordered locus">SDY_2504</name>
        <name evidence="11" type="ordered locus">SDY_2627</name>
        <name evidence="12" type="ordered locus">SDY_2641</name>
        <name evidence="13" type="ordered locus">SDY_3594</name>
        <name evidence="14" type="ordered locus">SDY_4178</name>
        <name evidence="15" type="ordered locus">SDY_4312</name>
        <name evidence="16" type="ordered locus">SDY_4526</name>
        <name evidence="17" type="ordered locus">SDY_4594</name>
        <name evidence="18" type="ordered locus">SDY_P094</name>
    </gene>
    <organism evidence="4 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="18 19">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="4 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 19">Sd197</strain>
            <plasmid evidence="19">Plasmid pSD1_197</plasmid>
            <plasmid evidence="18">pSD1_197</plasmid>
            <plasmid evidence="18">Sd197</plasmid>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang J."/>
                <person name="Chen L."/>
                <person name="Jin Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Sd197</strain>
            <plasmid evidence="18">pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406095.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60256">
        <property type="protein sequence ID" value="ABB60256"/>
        <property type="gene ID" value="SDY_0016"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60339">
        <property type="protein sequence ID" value="ABB60339"/>
        <property type="gene ID" value="SDY_0103"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60624">
        <property type="protein sequence ID" value="ABB60624"/>
        <property type="gene ID" value="SDY_0413"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60866">
        <property type="protein sequence ID" value="ABB60866"/>
        <property type="gene ID" value="SDY_0678"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60885">
        <property type="protein sequence ID" value="ABB60885"/>
        <property type="gene ID" value="SDY_0700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61944">
        <property type="protein sequence ID" value="ABB61944"/>
        <property type="gene ID" value="SDY_1834"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62361">
        <property type="protein sequence ID" value="ABB62361"/>
        <property type="gene ID" value="SDY_2284"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62574">
        <property type="protein sequence ID" value="ABB62574"/>
        <property type="gene ID" value="SDY_2504"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62681">
        <property type="protein sequence ID" value="ABB62681"/>
        <property type="gene ID" value="SDY_2627"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62694">
        <property type="protein sequence ID" value="ABB62694"/>
        <property type="gene ID" value="SDY_2641"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63567">
        <property type="protein sequence ID" value="ABB63567"/>
        <property type="gene ID" value="SDY_3594"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64083">
        <property type="protein sequence ID" value="ABB64083"/>
        <property type="gene ID" value="SDY_4178"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64208">
        <property type="protein sequence ID" value="ABB64208"/>
        <property type="gene ID" value="SDY_4312"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64400">
        <property type="protein sequence ID" value="ABB64400"/>
        <property type="gene ID" value="SDY_4526"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64454">
        <property type="protein sequence ID" value="ABB64454"/>
        <property type="gene ID" value="SDY_4594"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64607">
        <property type="protein sequence ID" value="ABB64607"/>
        <property type="gene ID" value="SDY_P094"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0016"/>
    <dbReference type="KEGG" id="sdy:SDY_0103"/>
    <dbReference type="KEGG" id="sdy:SDY_0413"/>
    <dbReference type="KEGG" id="sdy:SDY_0678"/>
    <dbReference type="KEGG" id="sdy:SDY_0700"/>
    <dbReference type="KEGG" id="sdy:SDY_1834"/>
    <dbReference type="KEGG" id="sdy:SDY_2284"/>
    <dbReference type="KEGG" id="sdy:SDY_2504"/>
    <dbReference type="KEGG" id="sdy:SDY_2627"/>
    <dbReference type="KEGG" id="sdy:SDY_2641"/>
    <dbReference type="KEGG" id="sdy:SDY_3594"/>
    <dbReference type="KEGG" id="sdy:SDY_4178"/>
    <dbReference type="KEGG" id="sdy:SDY_4312"/>
    <dbReference type="KEGG" id="sdy:SDY_4526"/>
    <dbReference type="KEGG" id="sdy:SDY_4594"/>
    <dbReference type="KEGG" id="sdy:SDY_P094"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5644"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0614">Plasmid</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB60624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB60866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB62574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB62694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB63567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB64083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB64208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB64400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB64454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB64607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="8498" checksum="46598928F4135D00" modified="2005-12-06" version="1">MITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K42</accession>
    <name>PDXA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.262</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-(phosphohydroxy)-L-threonine dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxA</name>
        <name type="ordered locus">SDY_0077</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32275"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="EC" id="1.1.1.262"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The active site is located at the dimer interface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PdxA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.262" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000241239.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401804.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K42"/>
    <dbReference type="SMR" id="Q32K42"/>
    <dbReference type="STRING" id="300267.SDY_0077"/>
    <dbReference type="EnsemblBacteria" id="ABB60315">
        <property type="protein sequence ID" value="ABB60315"/>
        <property type="gene ID" value="SDY_0077"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0077"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.87"/>
    <dbReference type="HOGENOM" id="CLU_040168_2_0_6"/>
    <dbReference type="OMA" id="TAQVVMM"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00536">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037510">
        <property type="entry name" value="PdxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000051515" description="4-hydroxythreonine-4-phosphate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00536"/>
        </source>
    </evidence>
    <sequence length="329" mass="35120" checksum="EFCC745DF04FA294" modified="2005-12-06" version="1">MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTDRAAMLGLPLTLRPYSPNSPAQPQTAGILTLLPVALRESVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSRAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIGTIIPVLDELRAQGMKLSGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGEADVGSFITALNLAIKMIVNTQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K45</accession>
    <name>APAH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bis(5'-nucleosyl)-tetraphosphatase, symmetrical</fullName>
            <ecNumber evidence="1">3.6.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ap4A hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Diadenosine tetraphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">apaH</name>
        <name type="ordered locus">SDY_0074</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.41"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ap4A hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.41" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000257202.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401801.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K45"/>
    <dbReference type="SMR" id="Q32K45"/>
    <dbReference type="STRING" id="300267.SDY_0074"/>
    <dbReference type="EnsemblBacteria" id="ABB60312">
        <property type="protein sequence ID" value="ABB60312"/>
        <property type="gene ID" value="SDY_0074"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0074"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.84"/>
    <dbReference type="HOGENOM" id="CLU_056184_2_0_6"/>
    <dbReference type="OMA" id="INAFTRM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008803">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07422">
        <property type="entry name" value="MPP_ApaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00199">
        <property type="entry name" value="ApaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004617">
        <property type="entry name" value="ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000903">
        <property type="entry name" value="B5n-ttraPtase_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00668">
        <property type="entry name" value="apaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000012098" description="Bis(5'-nucleosyl)-tetraphosphatase, symmetrical">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00199"/>
        </source>
    </evidence>
    <sequence length="282" mass="31500" checksum="3152A50E683D59F7" modified="2005-12-06" version="1">MATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVRLVLGNHDLHLLAVFTGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAHAGITPQWDLPTAKDCARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELRGLGRLRFITNAFTRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGIYALDTGCCWGGSLTCLRWEDKQYFVQPSNRHKDMGEGEAVAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-29" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K70</accession>
    <name>LSPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="1">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Signal peptidase II</fullName>
            <shortName evidence="1">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lspA</name>
        <name type="ordered locus">SDY_0049</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000083369.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401776.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K70"/>
    <dbReference type="SMR" id="Q32K70"/>
    <dbReference type="STRING" id="300267.SDY_0049"/>
    <dbReference type="MEROPS" id="A08.001"/>
    <dbReference type="EnsemblBacteria" id="ABB60287">
        <property type="protein sequence ID" value="ABB60287"/>
        <property type="gene ID" value="SDY_0049"/>
    </dbReference>
    <dbReference type="GeneID" id="67416102"/>
    <dbReference type="KEGG" id="sdy:SDY_0049"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.53"/>
    <dbReference type="HOGENOM" id="CLU_083252_4_0_6"/>
    <dbReference type="OMA" id="NRWYFPA"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000289424" description="Lipoprotein signal peptidase">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <sequence length="164" mass="18128" checksum="65773737CA9A3EB1" modified="2005-12-06" version="1">MSQSICSTGLRWLWLVVVVLIIDLGSKYLILQNFALGDTVPLFPSLNLHYARNYGAAFSFLADSGGWQRWFFAGIAIGISVILAVMMYRSKATQKLNNIAYALIIGGALGNLFDRLWHGFVVDMIDFYVGDWHFATFNLADTAICVGAALIVLEGFLPSKAKKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K78</accession>
    <name>PAND_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="1" type="primary">panD</name>
        <name type="ordered locus">SDY_0041</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="1">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000621515.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401768.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K78"/>
    <dbReference type="SMR" id="Q32K78"/>
    <dbReference type="STRING" id="300267.SDY_0041"/>
    <dbReference type="EnsemblBacteria" id="ABB60279">
        <property type="protein sequence ID" value="ABB60279"/>
        <property type="gene ID" value="SDY_0041"/>
    </dbReference>
    <dbReference type="GeneID" id="66671580"/>
    <dbReference type="KEGG" id="sdy:SDY_0041"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.45"/>
    <dbReference type="HOGENOM" id="CLU_115305_2_1_6"/>
    <dbReference type="OMA" id="MLYSKIH"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_0000236891" description="Aspartate 1-decarboxylase beta chain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000236892" description="Aspartate 1-decarboxylase alpha chain" evidence="1">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <sequence length="126" mass="13834" checksum="E3169F5C2BDD5D25" modified="2005-12-06" version="1" precursor="true">MIRTMLQGKLHRVKVTHADLHYEGSCAIDQDFLDAAGILENEAIDIWNVTNGKRFSTYAIAAERGSRIISVNGAAAHCASVGDIVIIASFVTMPDEEARTWRPNVAYFEGDNEMKRTAKAIPVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q327B2</accession>
    <name>Q327B2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iso-IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_P083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Sd197</strain>
            <plasmid evidence="9">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406084.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327B2"/>
    <dbReference type="EnsemblBacteria" id="ABB64596">
        <property type="protein sequence ID" value="ABB64596"/>
        <property type="gene ID" value="SDY_P083"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P083"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5633"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_0_6"/>
    <dbReference type="OMA" id="SCYTART"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="90" mass="10217" checksum="DD28505E509A28F2" modified="2005-12-06" version="1">MATVTVHCPRCHSDEVYRHGRSCSRHERFRCRSCKRVFQLTYSYEARKPGVKEQIVEMAHNGAGSCYTARTLKTGINTVIRTLKSSRPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q327H4</accession>
    <name>Q327H4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative IS orf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SDY_P021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Sd197</strain>
            <plasmid evidence="6">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406022.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327H4"/>
    <dbReference type="EnsemblBacteria" id="ABB64534">
        <property type="protein sequence ID" value="ABB64534"/>
        <property type="gene ID" value="SDY_P021"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P021"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5556"/>
    <dbReference type="HOGENOM" id="CLU_023034_2_0_6"/>
    <dbReference type="OMA" id="FFELHAN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024463">
        <property type="entry name" value="Transposase_TnpC_homeodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024474">
        <property type="entry name" value="Znf_dom_IS66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13007">
        <property type="entry name" value="LZ_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13005">
        <property type="entry name" value="zf-IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LZ_Tnp_IS66" evidence="4">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="zf-IS66" evidence="3">
        <location>
            <begin position="92"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="2">
        <location>
            <begin position="151"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="399" mass="44411" checksum="EE55CF631AFA5BFC" modified="2005-12-06" version="1">MAAYASEINRLKALVAKLQRMQFGKSSEKLRAKTERQIQEAQERISALQEEMAETLGEQYDPVLPSPLRQSSARKPLPASLPRETRVIRPEEECCPACGGELSSLGCDVSEQLELISSAFKVIETQRPKLACCRCDHIVQAPVPSKPIARSYAGAGLLAHVVAGKYADYLPLYRQSEIYRRQGVELSRATLGRWTGAVAELLELLYDILRQYVLMPGKVHADDIPVPVQEPGSGKTRTARLWVYVRDDRNAGSEMPPAVWFAYSPDRKGIHPQNHLAGYSGVLQADAYGGYRALYESGRITEAACMAHVRRKIHDVHARVPTDITTEALQRIGELYAIEAEVRGCSAEQRLAARKARAAPLMQSLYDWIQQQMKIHSLKMECLHGEHYYPSGNSAGNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q327M3</accession>
    <name>Q327M3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjjG</name>
        <name evidence="2" type="ordered locus">SDY_4633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000870720.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405973.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327M3"/>
    <dbReference type="STRING" id="300267.SDY_4633"/>
    <dbReference type="EnsemblBacteria" id="ABB64482">
        <property type="protein sequence ID" value="ABB64482"/>
        <property type="gene ID" value="SDY_4633"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4633"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5491"/>
    <dbReference type="HOGENOM" id="CLU_045011_8_1_6"/>
    <dbReference type="OMA" id="DHTLWDF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011951">
        <property type="entry name" value="HAD-SF_hydro_IA_YjjG/PynA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02254">
        <property type="entry name" value="YjjG/YfnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="225" mass="25277" checksum="A9653475CBFB3AF0" modified="2005-12-06" version="1">MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHGRFQSWAERLNVEPGKLNEAFINAMAEICTPLPGAVSLLNAIRGNAKIGIITNGFSALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYALEQAGNPDRSRVLMVGDTAESDILGGINAGLATCWLNAHNREQPEGIAPTWTVSSLHELEQLLCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q327R1</accession>
    <name>Q327R1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327R1"/>
    <dbReference type="STRING" id="300267.SDY_4583"/>
    <dbReference type="EnsemblBacteria" id="ABB64444">
        <property type="protein sequence ID" value="ABB64444"/>
        <property type="gene ID" value="SDY_4583"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4583"/>
    <dbReference type="HOGENOM" id="CLU_2755650_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="70" mass="7933" checksum="779E8956E6F3228A" modified="2005-12-06" version="1">MTSLKTSIKTITYLSDTGCLEIQGASLIHQIPDTSLQWEIVVAIGDDSNLLMVFYVQIMPDDFVMQLHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q327U0</accession>
    <name>Q327U0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yhjE</name>
        <name evidence="10" type="ordered locus">SDY_4543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001148989.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405906.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327U0"/>
    <dbReference type="EnsemblBacteria" id="ABB64415">
        <property type="protein sequence ID" value="ABB64415"/>
        <property type="gene ID" value="SDY_4543"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4543"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5371"/>
    <dbReference type="HOGENOM" id="CLU_001265_39_5_6"/>
    <dbReference type="OMA" id="SWVGGYV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004736">
        <property type="entry name" value="MHS_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00883">
        <property type="entry name" value="2A0106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="23"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="440" mass="47273" checksum="8A48F65568F42A1C" modified="2005-12-06" version="1">MQATATTLDHEQEYTPINSRNKVLVASLIGTAIEFFDFYIYATAAVIVFPHIFFLQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKATLVASLLTMGISTVVIGLLPGYATIGIFAPLLLALARFGQGLGLGGEWGGAALLATENAPPRKRALYGSFPQLGAPIGFFFANGTFLLLSWLLTDEQFMSWGWRVPFIFSAVLVIIGLYVRVSLHESPVFEKVAKAKKQVKIPLGTLLTKHVRVTVLGTFIMLATYTLFYIMTVYSMTFSTAATPVGLGLPRNEVLWMLMMAVIGFGVMVPVAGLLADAFGRRKSMVIITTLIILFALFAFNPLLGSGSPILVFAFLLLGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVASILGASVAPYIAAWLQTNYGLGAVGLYLAAMACLTLIALLLTHETRHQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q327V6</accession>
    <name>Q327V6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine(20/20a) synthase</fullName>
            <ecNumber evidence="6">1.3.1.91</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">U20-specific dihydrouridine synthase</fullName>
            <shortName evidence="6">U20-specific Dus</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-dihydrouridine synthase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yjbN</name>
        <name evidence="6" type="synonym">dusA</name>
        <name evidence="10" type="ordered locus">SDY_4525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(20) in tRNA + NAD(+) = H(+) + NADH + uridine(20) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53340"/>
            <dbReference type="Rhea" id="RHEA-COMP:13533"/>
            <dbReference type="Rhea" id="RHEA-COMP:13534"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.91"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(20) in tRNA + NADP(+) = H(+) + NADPH + uridine(20) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53336"/>
            <dbReference type="Rhea" id="RHEA-COMP:13533"/>
            <dbReference type="Rhea" id="RHEA-COMP:13534"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.91"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(20a) in tRNA + NAD(+) = H(+) + NADH + uridine(20a) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53348"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(20a) in tRNA + NADP(+) = H(+) + NADPH + uridine(20a) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53344"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Dus family. DusA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.91" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378970.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405890.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327V6"/>
    <dbReference type="STRING" id="300267.SDY_4525"/>
    <dbReference type="EnsemblBacteria" id="ABB64399">
        <property type="protein sequence ID" value="ABB64399"/>
        <property type="gene ID" value="SDY_4525"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4525"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5348"/>
    <dbReference type="HOGENOM" id="CLU_013299_2_1_6"/>
    <dbReference type="OMA" id="LIYPYVD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102264">
        <property type="term" value="F:tRNA-dihydrouridine20 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02041">
        <property type="entry name" value="DusA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="PTHR42907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00742">
        <property type="entry name" value="yjbN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Dus" evidence="9">
        <location>
            <begin position="30"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="site" description="Interacts with tRNA" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with tRNA; defines subfamily-specific binding signature" evidence="6">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with tRNA" evidence="6">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with tRNA; defines subfamily-specific binding signature" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with tRNA; defines subfamily-specific binding signature" evidence="6">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="345" mass="38410" checksum="4E9DEB3D2E03F698" modified="2005-12-06" version="1">MHGNSEMQKINQTSAMPEKTDVHWSGRFSVAPMLDWTDRHCRYFLRLLSRNTLLYTEMVTTGAIIHGKGDYLAYSEEEHPVALQLGGSDPAALAQCAKLAEARGYDEINLNVGCPSDRVQNGMFGACLMGNAQLVADCVKAMRDVVSIPVTVKTRIGIDDQDSYEFLCGFINTVSGKGECEMFIIHARKAWLSGLSPKENREIPPLDYPRVYQLKRDFPHLTMSINGGIKSLEEAKAHLQHMDGVMVGREAYQNPGILAAVDREIFGSSDTDADPVAVVRAMYPYIERELSQGTYLGHITRHMLGLFQGIPGARQWRRYLSENAHKAGADINVLEHALKLVADKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Z9</accession>
    <name>Q327Z9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ISSfl4 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000612546.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405847.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Z9"/>
    <dbReference type="EnsemblBacteria" id="ABB64356">
        <property type="protein sequence ID" value="ABB64356"/>
        <property type="gene ID" value="SDY_4480"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4480"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5290"/>
    <dbReference type="HOGENOM" id="CLU_128110_1_2_6"/>
    <dbReference type="OMA" id="NTRIWIA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008878">
        <property type="entry name" value="Transposase_IS66_Orf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36455">
        <property type="entry name" value="PTHR36455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05717">
        <property type="entry name" value="TnpB_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="115" mass="12826" checksum="569B7B14E6A81157" modified="2005-12-06" version="1">MIPLPSGTKIWLVAGITDIRNGFNSLAAKVQTALKDDPMSGHVFIFRGRSGSQVKRLWSTGDGLCLLTKRLERGRFAWPSARDGKVFLTQAQLAMLLEGIDWRQPKRLLTSLTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q328C9</accession>
    <name>Q328C9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Aspartate ammonia-lyase</fullName>
            <shortName evidence="5">Aspartase</shortName>
            <ecNumber evidence="3 5">4.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aspA</name>
        <name evidence="8" type="ordered locus">SDY_4444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-aspartate = fumarate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16601"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="4.3.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.1" evidence="3 5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405817.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328C9"/>
    <dbReference type="STRING" id="300267.SDY_4444"/>
    <dbReference type="EnsemblBacteria" id="ABB64326">
        <property type="protein sequence ID" value="ABB64326"/>
        <property type="gene ID" value="SDY_4444"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4444"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5242"/>
    <dbReference type="HOGENOM" id="CLU_021594_4_0_6"/>
    <dbReference type="OMA" id="EICENYV"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006531">
        <property type="term" value="P:aspartate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004708">
        <property type="entry name" value="ApsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00839">
        <property type="entry name" value="aspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="28"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="7">
        <location>
            <begin position="426"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="493" mass="54064" checksum="3CE9856B4304646C" modified="2005-12-06" version="1">MCLKQIIGSLKKKVHMSNNIRIEEDLLGTREVPADAYYGVHTLRAIENFYISNNKISDIPEFVRGMVMVKKAAAMANKELQTIPKSVANAIIAACDEVLNNGKCMDQFPVDVYQGGAGTSVNMNTNEVLANIGLELMGHQKGEYQYLNPNDHVNKCQSTNDAYPTGFRIAVYSSLIKLVDAINQLREGFERKAVEFQDILKMGRTQLQDAVPMTLGQEFRAFSILLKEEVKNIQRTAELLLEVNLGATAIGTGLNTPKEYSPLAVKKLAEVTGFPCVPAEDLIEATSDCGAYVMVHGALKRLAVKMSKICNDLRLLSSGPRAGLNEINLPELQAGSSIMPAKVNPVVPEVVNQVCFKVIGNDTTVTMAAEAGQLQLNVMEPVIGQAMFESVHILTNACYNLLEKCINGITANKEVCEGYVYNSIGIVTYLNPFIGHHNGDIVGKICAETGKSVREVVLERGLLTEAELDDIFSVQNLMHPAYKAKRYTDESEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q328L6</accession>
    <name>Q328L6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yiaG</name>
        <name evidence="2" type="ordered locus">SDY_4348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000455798.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405730.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328L6"/>
    <dbReference type="SMR" id="Q328L6"/>
    <dbReference type="STRING" id="300267.SDY_4348"/>
    <dbReference type="EnsemblBacteria" id="ABB64239">
        <property type="protein sequence ID" value="ABB64239"/>
        <property type="gene ID" value="SDY_4348"/>
    </dbReference>
    <dbReference type="GeneID" id="66672556"/>
    <dbReference type="KEGG" id="sdy:SDY_4348"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5132"/>
    <dbReference type="HOGENOM" id="CLU_144725_2_0_6"/>
    <dbReference type="OMA" id="MAMPEPQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="96" mass="11033" checksum="A0BC34F733957268" modified="2005-12-06" version="1">MEYKDPMHELLSSLEQIVFKDETQKITLTHRTTSCTEIEQLRKGTGLKIDDFARVLGVSVAMVKEWESRRVKPSSAELKLMRLIQANPALSKQLME</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q328U0</accession>
    <name>PYRB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="1">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartate transcarbamylase</fullName>
            <shortName evidence="1">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrB</name>
        <name type="ordered locus">SDY_4264</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000013046.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405656.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328U0"/>
    <dbReference type="SMR" id="Q328U0"/>
    <dbReference type="STRING" id="300267.SDY_4264"/>
    <dbReference type="EnsemblBacteria" id="ABB64165">
        <property type="protein sequence ID" value="ABB64165"/>
        <property type="gene ID" value="SDY_4264"/>
    </dbReference>
    <dbReference type="GeneID" id="66671836"/>
    <dbReference type="KEGG" id="sdy:SDY_4264"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5027"/>
    <dbReference type="HOGENOM" id="CLU_043846_1_2_6"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000301619" description="Aspartate carbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <sequence length="311" mass="34427" checksum="CC2F5ACBD73E0E3E" modified="2005-12-06" version="1">MANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERLDPSEYANVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRDLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q328V3</accession>
    <name>Q328V3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase</fullName>
            <ecNumber evidence="6">6.3.2.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Murein peptide ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yjfG</name>
        <name evidence="6" type="synonym">mpl</name>
        <name evidence="10" type="ordered locus">SDY_4251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:29563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61401"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. Mpl subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.45" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001219790.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405643.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328V3"/>
    <dbReference type="SMR" id="Q328V3"/>
    <dbReference type="STRING" id="300267.SDY_4251"/>
    <dbReference type="EnsemblBacteria" id="ABB64152">
        <property type="protein sequence ID" value="ABB64152"/>
        <property type="gene ID" value="SDY_4251"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4251"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5012"/>
    <dbReference type="HOGENOM" id="CLU_028104_0_1_6"/>
    <dbReference type="OMA" id="SGIAWDH"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106418">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02020">
        <property type="entry name" value="Mpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005757">
        <property type="entry name" value="Mpl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01081">
        <property type="entry name" value="mpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="9">
        <location>
            <begin position="108"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="8">
        <location>
            <begin position="312"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="110"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB64152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="457" mass="49895" checksum="1896BF6A6EC9A0EA" modified="2005-12-06" version="1">MRIHILGICGTFMGGLAMLARQLGHEVTGSDANVYPPMSTLLEKQGIELIQGYDASQLDPQPDLVIIGNAMTRGNPCVEAVLEKNIPYMSGPQWLHDFVLRDRWVLAVAGTHGKTTTAGMATWILEQCGYKPGFVIGGVPGNFEVSARLGESDFFVIEADEYDCAFFDKRSKFVHYCPRTLILNNLEFDHADIFDDLKAIQKQFHHLVRIVPGQGRIIWPENDINLKQTMAMGCWSEQELVGEQGHWQAKKLTTDASEWEVLLDGEKVGEVKWSLVGEHNMHNGLMAIAAARHVGVAPADAANALGSFINARRRLELRGEANGVTVYDDFAHHPTAILATLAALRGKVGGTARIIAVLEPRSNTMKMGICKDDLAPSLGRADEVFLLQPAHILWQVAEVAEACVQPAHWSGDVDTLADMVVKTAQPGDHILVMSNGGFGGIHQKLLDGLAKKAEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q329D7</accession>
    <name>Q329D7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yidG</name>
        <name evidence="7" type="ordered locus">SDY_4159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001113428.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405559.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329D7"/>
    <dbReference type="STRING" id="300267.SDY_4159"/>
    <dbReference type="EnsemblBacteria" id="ABB64068">
        <property type="protein sequence ID" value="ABB64068"/>
        <property type="gene ID" value="SDY_4159"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4159"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4888"/>
    <dbReference type="HOGENOM" id="CLU_150487_2_0_6"/>
    <dbReference type="OMA" id="ILWRYTR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB64068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="120" mass="13750" checksum="4DE2ECE251F5D7A2" modified="2005-12-06" version="1">MPDSRKARRIADPGLQPERTSLAWFRTMLGYGALMALAIKHNWHQAGMLFWISIGILAIVALILWHYTRNRNLIDVTNSDFSQFHVVRDKFLISLAVLSLAILFAVTHIHQLIVFIERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q329L2</accession>
    <name>Q329L2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yicC</name>
        <name evidence="4" type="ordered locus">SDY_4075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000621319.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405484.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329L2"/>
    <dbReference type="STRING" id="300267.SDY_4075"/>
    <dbReference type="EnsemblBacteria" id="ABB63993">
        <property type="protein sequence ID" value="ABB63993"/>
        <property type="gene ID" value="SDY_4075"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4075"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4794"/>
    <dbReference type="HOGENOM" id="CLU_076609_0_0_6"/>
    <dbReference type="OMA" id="EIKSVNH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="3">
        <location>
            <begin position="203"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="287" mass="33183" checksum="A9A11E516E41C002" modified="2005-12-06" version="1">MIRSMTAYARREIKGEWGSATWEMRSVNQRYLETYFRLPEQFRSLEPVVRERIRPRLTRGKVECTLRYEPDVSAQGELILNEKLAKQLVTAANWVKMQSDEGEINPVDILRWPGVMAAQEQDLDAIAAEILAALDGTLDDFIIARETEGQALKALIEQRLEGVTAEVVKVRAHMPEILQWQRERLVAKLEDAQVQLENNRLEQELVLLAQRIDVAEELDRLEAHVKETYNILKKKEAVGRRLDFMMQEFNRESNTLASKSINAEVTNSAIELKVLIEQMREQIQNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q329N3</accession>
    <name>Q329N3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid A-core:surface polymer ligase WaaL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">waaL</name>
        <name evidence="4" type="ordered locus">SDY_4054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000453199.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405463.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329N3"/>
    <dbReference type="STRING" id="300267.SDY_4054"/>
    <dbReference type="EnsemblBacteria" id="ABB63972">
        <property type="protein sequence ID" value="ABB63972"/>
        <property type="gene ID" value="SDY_4054"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4054"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4770"/>
    <dbReference type="HOGENOM" id="CLU_054167_0_0_6"/>
    <dbReference type="OMA" id="MLIAWLM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="417" mass="47393" checksum="7FBB89EFEC6D18DB" modified="2005-12-06" version="1">MEVKIEQFRNNSCNFIFLLYLIGLLFVPIDLNITTKIINATGAFSLFLLIVNKKHNYNKNVIILILGLLLLGAMNLIWYEFYKTEDVVYRNAYRGYLESGKLLVFSSLTFLLLSKNKLRQNEKLHFISAILVQIIMLCRAYYQGIYLHADRIPLSAMNGNIGQMGAATIAAYVITFTTLYSSIVFIKMQSKYKWFLFYANFALSFAAVMMTGTRAAIFTFPLMIMVILFLQHRDQKVFLFKGLSGVFILLLACGLIFNKEIERRINSLKADVISYATKNNSQSSIGARFAMVNAGIKGSPDGFNWQSLEQRAEKIKALSADNNIYSGALLFLDVHMHNEIVEALSTKGKIGLLVLIMFYVEIIYYCIREKKYILLVFPASIMLFGISDVITHAKPIPASWIVCLFLSISFLSKKEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q329R1</accession>
    <name>Q329R1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoU</name>
        <name evidence="6" type="ordered locus">SDY_4026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000377785.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405435.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329R1"/>
    <dbReference type="STRING" id="300267.SDY_4026"/>
    <dbReference type="EnsemblBacteria" id="ABB63944">
        <property type="protein sequence ID" value="ABB63944"/>
        <property type="gene ID" value="SDY_4026"/>
    </dbReference>
    <dbReference type="GeneID" id="58463285"/>
    <dbReference type="KEGG" id="sdy:SDY_4026"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4740"/>
    <dbReference type="HOGENOM" id="CLU_078518_2_1_6"/>
    <dbReference type="OMA" id="WKHGIET"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="5">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="5">
        <location>
            <begin position="128"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB63944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="241" mass="27442" checksum="21ADAECC3827FACD" modified="2005-12-06" version="1">MDSLNLNKHISGQFNAELESIRTQVMTMGGMVEQQLSDAITAMHNQDSDLAKRVIEGDKNVNMMEVAIDEACVRIIAKRQPTASDLRLVMVISKTIAELERIGDVADKICRTALEKFSQQHQPLLVSLESLGRHTIQMLHDVLDAFARMDIDEAVRIYREDKKVDQEYEGIVRQLMTYMMEDSRTIPSVLTALFCARSIERIGDRCQNICEFIFYYVKGQDFRHVGGDELDKLLAGKDPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q329W7</accession>
    <name>Q329W7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rffH</name>
        <name evidence="7" type="ordered locus">SDY_3959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000676045.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405379.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329W7"/>
    <dbReference type="STRING" id="300267.SDY_3959"/>
    <dbReference type="EnsemblBacteria" id="ABB63888">
        <property type="protein sequence ID" value="ABB63888"/>
        <property type="gene ID" value="SDY_3959"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3959"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4670"/>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_6"/>
    <dbReference type="OMA" id="ITHAIQW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB63888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="293" mass="32792" checksum="EAFBA555004DBD1B" modified="2005-12-06" version="1">MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIREILIITTPEDKGYFQRLLGDDSEFGIQLEYAEQPSPDGLAQAFIIGETFLNGEPSCLVLGDNIFFGQGFSPKLRHVAARTEGATVFGYQVMDPERFGVVEFDDNFRAISLEEKPKQPKSNWAVTGLYFYDSKVVEYAKQVKPSERGELEITSINQMYLEAGNLTVELLGRGFAWLDTGTHDSLIEASTFVQTVEKRQGFKIACLEEIAWRNGWLDDEGVKRAASSLAKTGYGQYLLELLRARPRQY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A21</accession>
    <name>FADB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acid oxidation complex subunit alpha</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase</fullName>
                <ecNumber evidence="1">4.2.1.17</ecNumber>
                <ecNumber evidence="1">5.1.2.3</ecNumber>
                <ecNumber evidence="1">5.3.3.8</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-hydroxyacyl-CoA dehydrogenase</fullName>
                <ecNumber evidence="1">1.1.1.35</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">fadB</name>
        <name type="ordered locus">SDY_3899</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:21760"/>
            <dbReference type="ChEBI" id="CHEBI:57315"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="EC" id="5.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45900"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="ChEBI" id="CHEBI:85489"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45228"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EC" id="5.1.2.3" evidence="1"/>
    <dbReference type="EC" id="5.3.3.8" evidence="1"/>
    <dbReference type="EC" id="1.1.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000966022.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405325.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A21"/>
    <dbReference type="SMR" id="Q32A21"/>
    <dbReference type="STRING" id="300267.SDY_3899"/>
    <dbReference type="EnsemblBacteria" id="ABB63834">
        <property type="protein sequence ID" value="ABB63834"/>
        <property type="gene ID" value="SDY_3899"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3899"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4607"/>
    <dbReference type="HOGENOM" id="CLU_009834_16_3_6"/>
    <dbReference type="OMA" id="TGAGWPF"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036125">
        <property type="term" value="C:fatty acid beta-oxidation multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008692">
        <property type="term" value="F:3-hydroxybutyryl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01621">
        <property type="entry name" value="FadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012799">
        <property type="entry name" value="FadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02437">
        <property type="entry name" value="FadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000255845" description="Fatty acid oxidation complex subunit alpha">
        <location>
            <begin position="1"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Enoyl-CoA hydratase/isomerase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-hydroxyacyl-CoA dehydrogenase" evidence="1">
        <location>
            <begin position="311"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="active site" description="For 3-hydroxyacyl-CoA dehydrogenase activity" evidence="1">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="400"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="660"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="729" mass="79591" checksum="CC32D93236E9C91C" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A26</accession>
    <name>Q32A26_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-guanine dinucleotide biosynthesis protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mobB</name>
        <name evidence="2" type="ordered locus">SDY_3889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405320.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A26"/>
    <dbReference type="STRING" id="300267.SDY_3889"/>
    <dbReference type="EnsemblBacteria" id="ABB63829">
        <property type="protein sequence ID" value="ABB63829"/>
        <property type="gene ID" value="SDY_3889"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3889"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4602"/>
    <dbReference type="HOGENOM" id="CLU_068199_2_1_6"/>
    <dbReference type="OMA" id="HTHHNMD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00176">
        <property type="entry name" value="mobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="170" mass="18898" checksum="730E1D6E772D47D8" modified="2005-12-06" version="1">MIPLLAFAAWSGTGKTTLLKKLIPALCARGIRPGLIKHTHHDMDVDKPGKDSYELRKAGAAQTIVASQQRWALMTETPDEEELDLHFLANRMDTSKLDLILVEGFKHEEIAKIVLFRDGAGHRPEELVIDRHVIAVASDVPLNLDVALLDINDVEGLADFVVEWMQNQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A46</accession>
    <name>Q32A46_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Shikimate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_3867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405300.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A46"/>
    <dbReference type="EnsemblBacteria" id="ABB63809">
        <property type="protein sequence ID" value="ABB63809"/>
        <property type="gene ID" value="SDY_3867"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3867"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4572"/>
    <dbReference type="HOGENOM" id="CLU_001265_39_4_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="234" mass="25982" checksum="E15AF920458F40DC" modified="2005-12-06" version="1">MTIESAPESRRGFLGSLPQTAASVGIMLATGIFALCNHFLTSEQFLSWGWRIPFWLSAVMLIVGLFIRLHTEETLDFQKQKTTNNKEKSVPPLIELFKKHPRNILLALGARLAESVSSNIINAFGIVYISSQLALSRDIPLTGMLIASAIGIFSCPLVGWLSDRIGQKSLYLSGAGFCVLFAFPFFLLLDSKSTLIIWCSMILGYNLGPTMMFAVQPTLFTRMFGTKVRYTGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AK5</accession>
    <name>Q32AK5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yrfC</name>
        <name evidence="2" type="ordered locus">SDY_3685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001069301.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405141.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AK5"/>
    <dbReference type="STRING" id="300267.SDY_3685"/>
    <dbReference type="EnsemblBacteria" id="ABB63650">
        <property type="protein sequence ID" value="ABB63650"/>
        <property type="gene ID" value="SDY_3685"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3685"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4372"/>
    <dbReference type="HOGENOM" id="CLU_081304_2_0_6"/>
    <dbReference type="OMA" id="HFTLRIT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="179" mass="20755" checksum="9A7738981E29DC64" modified="2005-12-06" version="1">MNPPINFLPWQQQRRTAFLRFWLLMFVAPPLLAVGITLILRLTSSAEARVDAVLLQGEQQLARSLQITKPRLLERQQIREQRLQRQCQRQFTRDWQSALEALAALLPEHAWLTTISWQQGTLEIKGLTTSITALNALETSLRQDASFHLNQRGATQQDAQGRWQFEYQLTRKVSDEHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AM1</accession>
    <name>Q32AM1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhgF</name>
        <name evidence="3" type="ordered locus">SDY_3669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405125.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AM1"/>
    <dbReference type="STRING" id="300267.SDY_3669"/>
    <dbReference type="EnsemblBacteria" id="ABB63634">
        <property type="protein sequence ID" value="ABB63634"/>
        <property type="gene ID" value="SDY_3669"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3669"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4354"/>
    <dbReference type="HOGENOM" id="CLU_009833_0_2_6"/>
    <dbReference type="OMA" id="RWAWRTR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="618"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="740" mass="81422" checksum="F73A0EF4BA023FB5" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AU9</accession>
    <name>Q32AU9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_3582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405047.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AU9"/>
    <dbReference type="STRING" id="300267.SDY_3582"/>
    <dbReference type="EnsemblBacteria" id="ABB63556">
        <property type="protein sequence ID" value="ABB63556"/>
        <property type="gene ID" value="SDY_3582"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3582"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4254"/>
    <dbReference type="HOGENOM" id="CLU_1634256_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB63556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="162" mass="18026" checksum="61F1716C06A8FECB" modified="2005-12-06" version="1">MNVNAGHERTSKARIIHQIQLIRGITKLLVAENPSPVVYTEKLWRRTIVSFSPDHERINHLMNQRKSELADVESYITTKECKMQFLRRALDEPGAEHCGKCSSCLQHPLLSPDIDSGLLHAANLFIKHADLPLNLNKQVAAGAFTQYGFKGNLPASLQGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AV0</accession>
    <name>Q32AV0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_3581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378889.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405046.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AV0"/>
    <dbReference type="STRING" id="300267.SDY_3581"/>
    <dbReference type="EnsemblBacteria" id="ABB63555">
        <property type="protein sequence ID" value="ABB63555"/>
        <property type="gene ID" value="SDY_3581"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3581"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4252"/>
    <dbReference type="HOGENOM" id="CLU_043668_0_0_6"/>
    <dbReference type="OMA" id="AMGRNKY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="431" mass="47125" checksum="FF6473A96AE8935B" modified="2005-12-06" version="1">MDADSSDSTVTPGRLPDGLSSCPCFYLGKKLMNLSANAQATLLLTSDFSRAAASEYKPLSNSEWGKFALWLKHQRISPAELLVPQPQEKLTGWSDPRISQERILGLLARGHSLALAVDKWQRAGLWILTRGDADYPVRLKNRLRTDAPPVLFGCGNKALLQAEGMAIVGSRDAPTDDLRYTQQLAAKLAQQGICVISGGARGIDECAMASALEAGGTAVGVLADSLLKTSTLVKWREGLIAGNLVLISPFYPEVRFTVGNAMARNKYIYCLAESAMVVRAGMTGGTITGAMEALKHQWLPVQVKPNQDMQSANSRLVENGASWSAEQAENVTIRLPDVPGLMYDRALRNAQPELFSLHEDDANYAVMPAYTPVDFYQLFVAELAILAKESIRIERLASCTGLTIEQISVWLNRAEEEGRVIRLGEGHYQFR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AV6</accession>
    <name>GLGA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycogen synthase</fullName>
            <ecNumber evidence="1">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgA</name>
        <name type="ordered locus">SDY_3575</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001197650.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405040.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AV6"/>
    <dbReference type="SMR" id="Q32AV6"/>
    <dbReference type="STRING" id="300267.SDY_3575"/>
    <dbReference type="CAZy" id="GT5">
        <property type="family name" value="Glycosyltransferase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63549">
        <property type="protein sequence ID" value="ABB63549"/>
        <property type="gene ID" value="SDY_3575"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3575"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4246"/>
    <dbReference type="HOGENOM" id="CLU_009583_18_2_6"/>
    <dbReference type="OMA" id="TWCPWYM"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000230264" description="Glycogen synthase">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <sequence length="477" mass="52821" checksum="09D6F4649D2B6859" modified="2005-12-06" version="1">MQVLHVCSEMFPLLKTGGLADVIGALPAAQIADGVDARVLLPAFPDIRRGVTDAQVVSRRDTFAGHITLLFGHYNGVGIYLIDAPHLYDRPGSPYHDTNLFAYTDNVLRFALLGWVGAEMASGLDPFWRPDVVHAHDWHAGLAPAYLAARGRPAKSVFTVHNLAYQGMFYAHHMNDIQLPWSFFNIHGLEFNGQISFLKAGLYYADHITAVSPTYAREITEPQFAYGMEGLLQQRHREGRLSGVLNGVDEKIWSPETDLLLASRYTRDTLEDKAKNKRQLQIAMGLKVDDKVPLFAVVSRLTSQKGLDLVLEALPGLLEQGGQLALLGAGDPVLQEGFLAAAAEYPGQVGVQIGYHEAFSHRIMGGADVILVPSRFEPCGLTQLYGLKYGTLPLVRRTGGLADTVSDCSLENLADGVASGFVFEDSNAWSLLRAIRRAFVLWSRPSLWRFVQRQAMAMDFSWQVAAKSYRELYYRLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AW6</accession>
    <name>RSMJ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase J</fullName>
            <ecNumber evidence="1">2.1.1.242</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m2G1516 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (guanine-N(2)-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmJ</name>
        <name type="synonym">yhiQ</name>
        <name type="ordered locus">SDY_3565</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the guanosine in position 1516 of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43220"/>
            <dbReference type="Rhea" id="RHEA-COMP:10412"/>
            <dbReference type="Rhea" id="RHEA-COMP:10413"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.242"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmJ family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.242" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001165120.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405030.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AW6"/>
    <dbReference type="SMR" id="Q32AW6"/>
    <dbReference type="STRING" id="300267.SDY_3565"/>
    <dbReference type="EnsemblBacteria" id="ABB63539">
        <property type="protein sequence ID" value="ABB63539"/>
        <property type="gene ID" value="SDY_3565"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3565"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4232"/>
    <dbReference type="HOGENOM" id="CLU_076324_0_0_6"/>
    <dbReference type="OMA" id="SRYDIYP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008990">
        <property type="term" value="F:rRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01523">
        <property type="entry name" value="16SrRNA_methyltr_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007536">
        <property type="entry name" value="16SrRNA_methylTrfase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36112">
        <property type="entry name" value="PTHR36112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04445">
        <property type="entry name" value="SAM_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000244284" description="Ribosomal RNA small subunit methyltransferase J">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01523"/>
        </source>
    </evidence>
    <sequence length="250" mass="26965" checksum="1E0FE9831F8C665D" modified="2005-12-06" version="1">MQICLIDETGTGDGALSVLATRWGLEHDEDNLMALVLTPEHLELRKRDEPKLGGIFVDFVGGAMAHRRKFGGGRGEAVAKAVGIKGDYLPDVVDATAGLGRDAFVLASVGCRVRMLERNPVVAALLDDGLARGYADAEIGGWLQERLQLIHASSLTALTDITPRPQVVYLDPMFPHKQKSALVKKEMRVFQSLVGPDLDADGLLEPARLLASKRVVVKRPDYAPPLANVATPNAVVTKGHRFDIYAGTPV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AZ8</accession>
    <name>CYSG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Siroheme synthase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
                <shortName evidence="1">Urogen III methylase</shortName>
                <ecNumber evidence="1">2.1.1.107</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">SUMT</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Uroporphyrinogen III methylase</fullName>
                <shortName evidence="1">UROM</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Precorrin-2 dehydrogenase</fullName>
                <ecNumber evidence="1">1.3.1.76</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Sirohydrochlorin ferrochelatase</fullName>
                <ecNumber evidence="1">4.99.1.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysG</name>
        <name type="ordered locus">SDY_3530</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + siroheme = Fe(2+) + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:24360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="EC" id="4.99.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; siroheme from sirohydrochlorin: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EC" id="1.3.1.76" evidence="1"/>
    <dbReference type="EC" id="4.99.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000349853.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404998.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AZ8"/>
    <dbReference type="SMR" id="Q32AZ8"/>
    <dbReference type="STRING" id="300267.SDY_3530"/>
    <dbReference type="EnsemblBacteria" id="ABB63507">
        <property type="protein sequence ID" value="ABB63507"/>
        <property type="gene ID" value="SDY_3530"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3530"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4184"/>
    <dbReference type="HOGENOM" id="CLU_011276_2_0_6"/>
    <dbReference type="OMA" id="GRFMAQE"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00211"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00211"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051266">
        <property type="term" value="F:sirohydrochlorin ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01646">
        <property type="entry name" value="Siroheme_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037115">
        <property type="entry name" value="Sirohaem_synt_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012409">
        <property type="entry name" value="Sirohaem_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019478">
        <property type="entry name" value="Sirohaem_synthase_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10414">
        <property type="entry name" value="CysG_dimeriser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036426">
        <property type="entry name" value="Sirohaem_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000330560" description="Siroheme synthase">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Precorrin-2 dehydrogenase /sirohydrochlorin ferrochelatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uroporphyrinogen-III C-methyltransferase" evidence="1">
        <location>
            <begin position="216"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="301"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="331"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01646"/>
        </source>
    </evidence>
    <sequence length="457" mass="50008" checksum="DDDE0DCA0F521119" modified="2005-12-06" version="1">MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLDAGARLTVNALAFIPQFTAWADAGMLTLVEGPFDESLLDTCWLAIAATDDDALNQRVSEAAEARRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPLHLGQVAKYAGQLRGRVKQQFATMGERRRFWEKLFVNDRLAQSLANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQQKLIEHDMPGEMPVAIVENGTAVTQRVIDGTLTQLGKLAQQMNSPSLIIIGRVVGLRDKLNWFSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B19</accession>
    <name>Q32B19_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fkpA</name>
        <name evidence="8" type="ordered locus">SDY_3508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000803038.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404977.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B19"/>
    <dbReference type="STRING" id="300267.SDY_3508"/>
    <dbReference type="EnsemblBacteria" id="ABB63486">
        <property type="protein sequence ID" value="ABB63486"/>
        <property type="gene ID" value="SDY_3508"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3508"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4162"/>
    <dbReference type="HOGENOM" id="CLU_013615_0_2_6"/>
    <dbReference type="OMA" id="KYMSGHI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000774">
        <property type="entry name" value="PPIase_FKBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036944">
        <property type="entry name" value="PPIase_FKBP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01346">
        <property type="entry name" value="FKBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220622" description="Peptidyl-prolyl cis-trans isomerase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="164"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="264" mass="28322" checksum="E63ABE5ADC68D984" modified="2005-12-06" version="1">MKPLFKVTLLATTMAVALHAPITFAAEAAKPATTADSKAAFKNDDQKSAYALGASLGRYMENSLKEQEKLGIKLDKDQLIAGVQDAFADKSKLSDQEIEQTLQAFEARVKSSAQAKMEKDAADNEAKGKEYREKFAKEKGVKTSSTGLVYQVVEAGKGEAPKDSDTVVVNYKGTLIDGKEFDNSYIRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPGIPPNSTLVFDVELLDVKPAPKADAKAADSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B20</accession>
    <name>Q32B20_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yheO</name>
        <name evidence="3" type="ordered locus">SDY_3507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404976.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B20"/>
    <dbReference type="STRING" id="300267.SDY_3507"/>
    <dbReference type="EnsemblBacteria" id="ABB63485">
        <property type="protein sequence ID" value="ABB63485"/>
        <property type="gene ID" value="SDY_3507"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3507"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4161"/>
    <dbReference type="HOGENOM" id="CLU_080179_3_0_6"/>
    <dbReference type="OMA" id="VMQTLEF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039446">
        <property type="entry name" value="DauR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013559">
        <property type="entry name" value="YheO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35568">
        <property type="entry name" value="PTHR35568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08348">
        <property type="entry name" value="PAS_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS_6" evidence="1">
        <location>
            <begin position="33"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_22" evidence="2">
        <location>
            <begin position="175"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="244" mass="27407" checksum="0D155F6BBE3C3559" modified="2005-12-06" version="1">MFFFMSRSLLTNETSELDLLDQRPFEQTDFDILKSYEAVVDGLAMLIGSHCEIVLHSLQDLKCSAIRIANGEHTGRKIGSPITDLALRMLHDMTGADSSVSKCYFTRAKSGVLMKSLTIAIRNREQRVIGLLCINMNLDVPFSQIMSTFVPPETPDVGSSVNFASSVEDLVTQTLEFTIEEVNADRNVSNNAKNRQIVLNLYEKGIFDIKDAINQVADRLNISKHTVYLYIRQFKSGDFQGQDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B35</accession>
    <name>RS19_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsS</name>
        <name type="ordered locus">SDY_3492</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001138117.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404961.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B35"/>
    <dbReference type="SMR" id="Q32B35"/>
    <dbReference type="STRING" id="300267.SDY_3492"/>
    <dbReference type="EnsemblBacteria" id="ABB63470">
        <property type="protein sequence ID" value="ABB63470"/>
        <property type="gene ID" value="SDY_3492"/>
    </dbReference>
    <dbReference type="GeneID" id="64727507"/>
    <dbReference type="GeneID" id="67463980"/>
    <dbReference type="KEGG" id="sdy:SDY_3492"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4145"/>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_6"/>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000265432" description="30S ribosomal protein S19">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <sequence length="92" mass="10430" checksum="439F951848E95CB8" modified="2005-12-06" version="1">MPRSLKKGPFIDLHLLKKVEKAVESGDKKPLRTWSRRSTIFPNMIGLTIAVHNGRQHVPVFVTDEMVGHKLGEFAPTRTYRGHAADKKAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B60</accession>
    <name>Q32B60_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trkA</name>
        <name evidence="11" type="ordered locus">SDY_3466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000691383.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404936.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B60"/>
    <dbReference type="STRING" id="300267.SDY_3466"/>
    <dbReference type="EnsemblBacteria" id="ABB63445">
        <property type="protein sequence ID" value="ABB63445"/>
        <property type="gene ID" value="SDY_3466"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3466"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4119"/>
    <dbReference type="HOGENOM" id="CLU_046525_0_2_6"/>
    <dbReference type="OMA" id="IACQVAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="10">
        <location>
            <begin position="143"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="10">
        <location>
            <begin position="368"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="458" mass="50367" checksum="1FF01BC23F4324E1" modified="2005-12-06" version="1">MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRTLQDKFDLRVVQGHGSHPRVLREAGADDADMLVAVTSSDETNMVACQVAYSLFNTPNRIARIRSPDYVRDADKLFHSDAVPIDHLIAPEQLVIDNIYRLIEYPGALQVVNFAEGKVSLAVVKAYYGGPLIGNALSTMREHMPHIDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSELQRLEKPYKRIMLVGGGNIGAGLARRLEKDYSVKLIERNQQRAAELAEKLQNTIVFFGDASDQELLAEEHIDQVDLFIAVTNDDEANIMSAMLAKRMGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLSHVRKADIVGVSSLRRGVAEAIEAVAHGDESTSRVVGRVIDEIKLPPGTIIGAVVRGNDVMIANDNLRIKQGDHVIMFLTDKKFITDVERLFQPSPFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B91</accession>
    <name>Q32B91_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rod shape-determining protein MreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mreD</name>
        <name evidence="10" type="ordered locus">SDY_3424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000179412.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404905.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B91"/>
    <dbReference type="STRING" id="300267.SDY_3424"/>
    <dbReference type="EnsemblBacteria" id="ABB63414">
        <property type="protein sequence ID" value="ABB63414"/>
        <property type="gene ID" value="SDY_3424"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3424"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4082"/>
    <dbReference type="HOGENOM" id="CLU_119315_0_1_6"/>
    <dbReference type="OMA" id="YWAMALP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026034">
        <property type="entry name" value="MreD_proteobac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37484">
        <property type="entry name" value="PTHR37484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018472">
        <property type="entry name" value="MreD_proteobac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB63414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="162" mass="18810" checksum="219DEAECCF8BE5C3" modified="2005-12-06" version="1">MASYRSQGRWVIWLSFLIALLLQIMPWPHNLIVFRPNWVLLILLYWILALPHRVNVGTGFVMGAILDLISGSTLGVRVLAMSIIAYLVALKYQLFRNLALWQQALVVMLLSLVVDIIVFWAEFLVINVSFRPEVFWSSVVNGVLWPWIFLLMRKVRQQFAVQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BA2</accession>
    <name>ARGR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argR</name>
        <name type="ordered locus">SDY_3413</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001257846.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404894.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BA2"/>
    <dbReference type="SMR" id="Q32BA2"/>
    <dbReference type="STRING" id="300267.SDY_3413"/>
    <dbReference type="EnsemblBacteria" id="ABB63403">
        <property type="protein sequence ID" value="ABB63403"/>
        <property type="gene ID" value="SDY_3413"/>
    </dbReference>
    <dbReference type="GeneID" id="66672867"/>
    <dbReference type="KEGG" id="sdy:SDY_3413"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4071"/>
    <dbReference type="HOGENOM" id="CLU_097103_2_0_6"/>
    <dbReference type="OMA" id="MVYCLPP"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000023598" description="Arginine repressor">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <sequence length="156" mass="16995" checksum="2F104577EFC46537" modified="2005-12-06" version="1">MRSSAKQEELVKAFKALLKEEKFSSQGEIVAALQEQGFDNINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTSSPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPANGFTVKDLYEAILELFDQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BF2</accession>
    <name>Q32BF2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ordered locus">SDY_3362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BF2"/>
    <dbReference type="SMR" id="Q32BF2"/>
    <dbReference type="STRING" id="300267.SDY_3362"/>
    <dbReference type="EnsemblBacteria" id="ABB63353">
        <property type="protein sequence ID" value="ABB63353"/>
        <property type="gene ID" value="SDY_3362"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3362"/>
    <dbReference type="HOGENOM" id="CLU_101379_2_0_6"/>
    <dbReference type="OMA" id="TWLTQEA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="78"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB63353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="153" mass="17100" checksum="A2B82C4919850B3C" modified="2005-12-06" version="1">MTLRGAEKLREELDFLKSVRRPEIIAAIAEAREHGDLKENAEYHAAREQQGFCEGRIKDIEAKLSNAQVIDVTKMPNNGRVIFGATVTVLNLDSDEEQTYRIVGDDEADFKQNLISVNSPIARGLIGKEEDDVVVIKTPGGEVEFEVIKVEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BJ7</accession>
    <name>Q32BJ7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BJ7"/>
    <dbReference type="EnsemblBacteria" id="ABB63308">
        <property type="protein sequence ID" value="ABB63308"/>
        <property type="gene ID" value="SDY_3312"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3312"/>
    <dbReference type="HOGENOM" id="CLU_076276_5_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7505" checksum="987E6F8FEBD7EEA1" modified="2005-12-06" version="1">MALICELDEQWSFVGSKARQHWLWYAYNTKTGGGLAYTFGPRTDETCRELLALLTPFNIGMITSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BM1</accession>
    <name>Q32BM1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yqjE</name>
        <name evidence="2" type="ordered locus">SDY_3286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000785723.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404775.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BM1"/>
    <dbReference type="STRING" id="300267.SDY_3286"/>
    <dbReference type="EnsemblBacteria" id="ABB63284">
        <property type="protein sequence ID" value="ABB63284"/>
        <property type="gene ID" value="SDY_3286"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3286"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3928"/>
    <dbReference type="HOGENOM" id="CLU_136851_0_0_6"/>
    <dbReference type="OMA" id="FWAIDPA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="134" mass="15161" checksum="9C2F4313E6853710" modified="2005-12-06" version="1">MADTHHAQGPGKSVLGIGQRIVSIMVEMVETRLRLAVVELEEEKANLFQLLLMLGLTMLFAAFGLMSLMVLIIWAVDPQYRLNAMIATTVVLLLLALIGGIWTLRKSRKSTLLRHTRHELANERQLLEEESREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BN7</accession>
    <name>Q32BN7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygjP</name>
        <name evidence="2" type="ordered locus">SDY_3268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404759.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BN7"/>
    <dbReference type="STRING" id="300267.SDY_3268"/>
    <dbReference type="EnsemblBacteria" id="ABB63268">
        <property type="protein sequence ID" value="ABB63268"/>
        <property type="gene ID" value="SDY_3268"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3268"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3908"/>
    <dbReference type="HOGENOM" id="CLU_101303_0_0_6"/>
    <dbReference type="OMA" id="LCCYMEP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="105"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="179" mass="20856" checksum="92B0BEBBEB6E9239" modified="2005-12-06" version="1">MSIPFFSFSWAVMSNLTYLQGYPEQLLSQVRTLINEQRLGDVLAKRYPGTHDYATDKALWQYTQDLKNQFLRNAPPINKVMYDNKIHVLKNALGLHTAVSRVQGGKLKAKAEIRVATVFRNAPEPFLRMIVVHELAHLKEKEHNKAFYQLCCHMEPQYHQLEFDTRLWLTQLSLGQDKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BS1</accession>
    <name>RIBB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="1">DHBP synthase</shortName>
            <ecNumber evidence="1">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ribB</name>
        <name type="ordered locus">SDY_3226</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001076997.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404725.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BS1"/>
    <dbReference type="SMR" id="Q32BS1"/>
    <dbReference type="STRING" id="300267.SDY_3226"/>
    <dbReference type="EnsemblBacteria" id="ABB63234">
        <property type="protein sequence ID" value="ABB63234"/>
        <property type="gene ID" value="SDY_3226"/>
    </dbReference>
    <dbReference type="GeneID" id="66673060"/>
    <dbReference type="KEGG" id="sdy:SDY_3226"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3852"/>
    <dbReference type="HOGENOM" id="CLU_020273_3_0_6"/>
    <dbReference type="OMA" id="DAGGLIC"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="chain" id="PRO_1000040635" description="3,4-dihydroxy-2-butanone 4-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="150"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00180"/>
        </source>
    </evidence>
    <sequence length="217" mass="23353" checksum="6833C120A1442608" modified="2005-12-06" version="1">MNQTLLSSFGTPFERVENALAALREGRGVMVLDDEDRENEGDMIFPAETMTVEQMALTIRHGSGIVCLCITEDRRKQLDLPMMVENNTSAYGTGFTVTIEAAEGVTTGVSAADRITTVRAAIADGAKPSDLNRPGHVFPLRAQAGGVLTRGGHTEATIDLMTLAGFKPAGVLCELTNDDGTMARAPECIEFANKHNMALVTIEDLVAYRQAHERKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BY4</accession>
    <name>Q32BY4_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yggB</name>
        <name evidence="8" type="ordered locus">SDY_3158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homoheptamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000389825.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404662.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BY4"/>
    <dbReference type="STRING" id="300267.SDY_3158"/>
    <dbReference type="EnsemblBacteria" id="ABB63171">
        <property type="protein sequence ID" value="ABB63171"/>
        <property type="gene ID" value="SDY_3158"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3158"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3771"/>
    <dbReference type="HOGENOM" id="CLU_037945_1_1_6"/>
    <dbReference type="OMA" id="GMQDTLT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006686">
        <property type="entry name" value="MscS_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008910">
        <property type="entry name" value="TM_helix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05552">
        <property type="entry name" value="TM_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01246">
        <property type="entry name" value="UPF0003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB63171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="286" mass="30923" checksum="FBF0606E5D03B354" modified="2005-12-06" version="1">MEDLNVVDSINGAGSWLVANQVLLLSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAGLAVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSREPVRRNEFIIGVAYDSNIDQVKQILTNIIQSEDRILKDREMTVRLNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRVKEDKAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BY6</accession>
    <name>PGK_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgk</name>
        <name type="ordered locus">SDY_3156</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005018348.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404660.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BY6"/>
    <dbReference type="SMR" id="Q32BY6"/>
    <dbReference type="STRING" id="300267.SDY_3156"/>
    <dbReference type="EnsemblBacteria" id="ABB63169">
        <property type="protein sequence ID" value="ABB63169"/>
        <property type="gene ID" value="SDY_3156"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3156"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3769"/>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_6"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000058065" description="Phosphoglycerate kinase">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="340"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <sequence length="387" mass="41090" checksum="FAD7D66D10179FB2" modified="2005-12-06" version="1">MSVIKMTDLDLAGKRVFIRADLNVPVKDGKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPTEGEYNEEFSLLPVVNYLKDKLSNPVRLVKDYLDGVDVAEGELVVLENVRFNKGEKKDDETLSKKYAALCDVFVMDAFGTAHRAQASTHGIGKFADVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAQGHDVGKSLYEADLVDEAKRLLTTCNIPVPSDVRVATEFSETAPATLKSVNDVKADEQILDIGDASAQELAEILKNAKTILWNGPVGVFEFPNFRKGTEIVANAIADSEAFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKALPAVAMLEERAKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C02</accession>
    <name>SPEB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Agmatinase</fullName>
            <ecNumber evidence="1">3.5.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Agmatine ureohydrolase</fullName>
            <shortName evidence="1">AUH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">speB</name>
        <name type="ordered locus">SDY_3139</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of putrescine from agmatine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>agmatine + H2O = putrescine + urea</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000105567.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404644.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C02"/>
    <dbReference type="SMR" id="Q32C02"/>
    <dbReference type="STRING" id="300267.SDY_3139"/>
    <dbReference type="EnsemblBacteria" id="ABB63153">
        <property type="protein sequence ID" value="ABB63153"/>
        <property type="gene ID" value="SDY_3139"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3139"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3748"/>
    <dbReference type="HOGENOM" id="CLU_039478_0_0_6"/>
    <dbReference type="OMA" id="YELTTIM"/>
    <dbReference type="UniPathway" id="UPA00534">
        <property type="reaction ID" value="UER00287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033388">
        <property type="term" value="P:putrescine biosynthetic process from arginine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01418">
        <property type="entry name" value="SpeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023694">
        <property type="entry name" value="Agmatinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword id="KW-0661">Putrescine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="chain" id="PRO_1000024285" description="Agmatinase">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01418"/>
        </source>
    </evidence>
    <sequence length="306" mass="33587" checksum="483D4BF2CF155570" modified="2005-12-06" version="1">MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHNRFPWNFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLAAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPNHSVQIGIRTEFDKDNGFTVLDACQVNDRSVDDVIAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C32</accession>
    <name>MLTC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Membrane-bound lytic murein transglycosylase C</fullName>
            <ecNumber evidence="1">4.2.2.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Murein lyase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mltC</name>
        <name type="ordered locus">SDY_3109</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exolytic cleavage of the (1-&gt;4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.</text>
            <dbReference type="EC" id="4.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63123" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="4.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63123.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404614.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C32"/>
    <dbReference type="SMR" id="Q32C32"/>
    <dbReference type="STRING" id="300267.SDY_3109"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63123">
        <property type="protein sequence ID" value="ABB63123"/>
        <property type="gene ID" value="SDY_3109"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3109"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3718"/>
    <dbReference type="HOGENOM" id="CLU_044583_0_0_6"/>
    <dbReference type="OMA" id="AIMQIES"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01616">
        <property type="entry name" value="MltC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023664">
        <property type="entry name" value="Murein_transglycosylaseC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024570">
        <property type="entry name" value="Murein_transglycosylaseC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11873">
        <property type="entry name" value="Mltc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000335588" description="Membrane-bound lytic murein transglycosylase C">
        <location>
            <begin position="17"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="359" mass="40112" checksum="3543FA42C36E1CA2" modified="2008-05-20" version="2" precursor="true">MKKYLALALIAPLLISCSTTQKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFKEVVIAGPKDYVKYTDQYQTRSHINFDDGTITIETIAGTEPAAHLRRAIIKTLLMGDDPSSVDLYSDVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLKNRLKSRSNGLRIIYSVTINMVPNHLDKRAHKYLGMVRQASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRSQGKSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMTPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C78</accession>
    <name>Q32C78_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_0619</name>
        <name evidence="9" type="ordered locus">SDY_3060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402301.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404568.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="STRING" id="300267.SDY_0619"/>
    <dbReference type="EnsemblBacteria" id="ABB60812">
        <property type="protein sequence ID" value="ABB60812"/>
        <property type="gene ID" value="SDY_0619"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB63077">
        <property type="protein sequence ID" value="ABB63077"/>
        <property type="gene ID" value="SDY_3060"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0619"/>
    <dbReference type="KEGG" id="sdy:SDY_3060"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3666"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB60812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB63077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="9958" checksum="E8924238CDA3AE64" modified="2005-12-06" version="1">MASVSISCPFCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVSLNTILRHLKNSGRSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CI2</accession>
    <name>FTSB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein FtsB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ftsB</name>
        <name type="ordered locus">SDY_2947</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of a complex composed of FtsB, FtsL and FtsQ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes to the division septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000517476.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404464.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CI2"/>
    <dbReference type="SMR" id="Q32CI2"/>
    <dbReference type="STRING" id="300267.SDY_2947"/>
    <dbReference type="EnsemblBacteria" id="ABB62973">
        <property type="protein sequence ID" value="ABB62973"/>
        <property type="gene ID" value="SDY_2947"/>
    </dbReference>
    <dbReference type="GeneID" id="66673378"/>
    <dbReference type="KEGG" id="sdy:SDY_2947"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3539"/>
    <dbReference type="HOGENOM" id="CLU_134863_5_2_6"/>
    <dbReference type="OMA" id="YELGMVK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00599">
        <property type="entry name" value="FtsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023081">
        <property type="entry name" value="Cell_div_FtsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37485">
        <property type="entry name" value="PTHR37485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000025728" description="Cell division protein FtsB">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="3"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00599"/>
        </source>
    </evidence>
    <sequence length="103" mass="11622" checksum="9B50A7EF637809D7" modified="2005-12-06" version="1">MGKLTLLLLAILVWLQYSLWFGKNGIHDYTRVNDDVAAQQATNAKLKARNDQLFAEIDDLNGGQEALEERARNELSMTRPGETFYRLVPDASKRAQSAGQNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CQ4</accession>
    <name>Q32CQ4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_2864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001138449.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404392.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CQ4"/>
    <dbReference type="STRING" id="300267.SDY_2864"/>
    <dbReference type="EnsemblBacteria" id="ABB62901">
        <property type="protein sequence ID" value="ABB62901"/>
        <property type="gene ID" value="SDY_2864"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2864"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3442"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_1_6"/>
    <dbReference type="OMA" id="AFPITNW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="444" mass="49731" checksum="58CD9BD6D63817CE" modified="2005-12-06" version="1">MPRYQDIARQLKTAIEQGKLKPGARLPSSRTWSQELGVSRSTVENAYAELVAQGWLVRRGQAGTFVSEQIHPQQSAVDVVAFAGESQQPLPFQMGLPALDLFPRELWARVMGRRLRTQTRFDLALGDVCGEAALREAIVDYLRVSRGIDCQPEQVFITHGYAASMALILHALAQPGDGMWMEDPGFPLIRPIVTRHGVEILPVPVDDNGLDVTSGIQNYPDARFALITPAHQSPLGVALSLARRYQILEWAERSQAWIIEDDYDSEFRYHGKPLPALKSLDAPQRVIYAGTFSKALFPALRCAWLLVPVEQISQFRQQASLEPCAVPVLWQNTLADFIREGHFWRHLKKMRQHYAQRRQWIEQALTQQGFQVVPQKGGIQMVIKLAGNDVTFVHKANAAGLAVQALSDWRIRSSEDGGLLLSFTNIVSESMARQVAQQLRSALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CR4</accession>
    <name>Q32CR4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ygaE</name>
        <name evidence="5" type="ordered locus">SDY_2854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CR4"/>
    <dbReference type="STRING" id="300267.SDY_2854"/>
    <dbReference type="EnsemblBacteria" id="ABB62891">
        <property type="protein sequence ID" value="ABB62891"/>
        <property type="gene ID" value="SDY_2854"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2854"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_3_6"/>
    <dbReference type="OMA" id="RYRHLWL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="226" mass="25717" checksum="A38637140EEE9159" modified="2005-12-06" version="1">MIRSHTMTITSLDGYRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLVSLAIARGGDEWEADVLAKAHLLSKLEACDASEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAARYRFIWLRRTVLSVEMLEDKHDQHQTLTAAVLARDTARASELMRQHLLTPIPIIQQAMAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D67</accession>
    <name>Q32D67_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">ppk</name>
        <name evidence="9" type="ordered locus">SDY_2690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000529580.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404229.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D67"/>
    <dbReference type="STRING" id="300267.SDY_2690"/>
    <dbReference type="EnsemblBacteria" id="ABB62738">
        <property type="protein sequence ID" value="ABB62738"/>
        <property type="gene ID" value="SDY_2690"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2690"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3245"/>
    <dbReference type="HOGENOM" id="CLU_009678_6_1_6"/>
    <dbReference type="OMA" id="NIKWARK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="688" mass="80448" checksum="72D11644F5FB4269" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D73</accession>
    <name>Q32D73_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arsenate reductase</fullName>
            <ecNumber evidence="3">1.20.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_2684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[glutaredoxin]-dithiol + arsenate + glutathione + H(+) = arsenite + glutathionyl-S-S-[glutaredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:22016"/>
            <dbReference type="Rhea" id="RHEA-COMP:10729"/>
            <dbReference type="Rhea" id="RHEA-COMP:17668"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29242"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:48597"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:146199"/>
            <dbReference type="EC" id="1.20.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000166449.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404223.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D73"/>
    <dbReference type="SMR" id="Q32D73"/>
    <dbReference type="STRING" id="300267.SDY_2684"/>
    <dbReference type="EnsemblBacteria" id="ABB62732">
        <property type="protein sequence ID" value="ABB62732"/>
        <property type="gene ID" value="SDY_2684"/>
    </dbReference>
    <dbReference type="GeneID" id="66673640"/>
    <dbReference type="KEGG" id="sdy:SDY_2684"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3238"/>
    <dbReference type="HOGENOM" id="CLU_116644_0_1_6"/>
    <dbReference type="OMA" id="MVTHPKL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03034">
        <property type="entry name" value="ArsC_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006659">
        <property type="entry name" value="Arsenate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00014">
        <property type="entry name" value="arsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="119" mass="13417" checksum="03067333B9B2676D" modified="2005-12-06" version="1">MTKQVKIYHNPRCSKSRETLNLLKENGVEPEVVLYLETPADAATLRDLLKMLGMNSARELMRQKEDLYKELNLADSSLSEEALIQAMVDNPKLMERPIVVANGKARIGRPPEQVLEIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q32D91</accession>
    <name>Q32D91_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SDY_2663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32D91"/>
    <dbReference type="STRING" id="300267.SDY_2663"/>
    <dbReference type="EnsemblBacteria" id="ABB62714">
        <property type="protein sequence ID" value="ABB62714"/>
        <property type="gene ID" value="SDY_2663"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2663"/>
    <dbReference type="HOGENOM" id="CLU_059329_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="181" mass="19654" checksum="B23E89CD52696E23" modified="2005-12-06" version="1">MGGPGFRLPSGKGGLILLIVVLVAGYYGVDLTGLMTGQPVSQQQSTRSISPNEDEAAKFTSVILATTEDTWGQQFEKMGKTYQQPKLVMYRGMTRTGCGAGQSIMGPFYCPADGTVYIDLSFYDDMKDKLGADGDFAQGYVIAHEVGHHVQKLLGIGPKVRQLQQNATQAEVNRLSVRMEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DP4</accession>
    <name>YFBV_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0208 membrane protein YfbV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfbV</name>
        <name type="ordered locus">SDY_2491</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0208 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000106627.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404052.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DP4"/>
    <dbReference type="STRING" id="300267.SDY_2491"/>
    <dbReference type="EnsemblBacteria" id="ABB62561">
        <property type="protein sequence ID" value="ABB62561"/>
        <property type="gene ID" value="SDY_2491"/>
    </dbReference>
    <dbReference type="GeneID" id="66673822"/>
    <dbReference type="KEGG" id="sdy:SDY_2491"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3002"/>
    <dbReference type="HOGENOM" id="CLU_128746_0_0_6"/>
    <dbReference type="OMA" id="WPVRKEL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01101">
        <property type="entry name" value="UPF0208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007334">
        <property type="entry name" value="UPF0208"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04217">
        <property type="entry name" value="DUF412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000064980" description="UPF0208 membrane protein YfbV">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01101"/>
        </source>
    </evidence>
    <sequence length="151" mass="17213" checksum="3818D038EBF60354" modified="2005-12-06" version="1">MSTPDNRSVNFFSLFRRGQHYSKTWPLEKRLAPVFVENRVIKMTRYAIRFMPPIAVFTLCWQIALGGQLGPAVATALFALSLPMQGLWWLGKRSVTPLPPAILNWFYEVRGKLQESGQVLAPVEGKPDYQALADTLKRAFKQLDKTFLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DP6</accession>
    <name>Q32DP6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfbT</name>
        <name evidence="2" type="ordered locus">SDY_2489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001203383.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404050.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DP6"/>
    <dbReference type="STRING" id="300267.SDY_2489"/>
    <dbReference type="EnsemblBacteria" id="ABB62559">
        <property type="protein sequence ID" value="ABB62559"/>
        <property type="gene ID" value="SDY_2489"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2489"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3000"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_6"/>
    <dbReference type="OMA" id="VVERSWC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="216" mass="23109" checksum="4F31242C88801FAA" modified="2005-12-06" version="1">MRCKGFLFDLDGTLVDSLPAVERAWSNWARRHGLAPEEVLAFIHGKQAITSLRHFMACKSEADIVAEFTRLEHIEATETEGITALPGAIALLNHLNKAGIPWAIVTSGSMPVARARHKIAGLPAPEVFVTAERVKRGKPEPDAYLLGAQLLGLAPQECVVVEDAPAGVLSGLAAGCHVIAVNAPADTPRLNEVDLVLHSLEQITVTKQPNGDVIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DU9</accession>
    <name>Q32DU9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DU9"/>
    <dbReference type="STRING" id="300267.SDY_2433"/>
    <dbReference type="EnsemblBacteria" id="ABB62506">
        <property type="protein sequence ID" value="ABB62506"/>
        <property type="gene ID" value="SDY_2433"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2433"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_6"/>
    <dbReference type="OMA" id="GIIRYFE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="15"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="217" mass="24190" checksum="B0AE7C319FE55CE2" modified="2005-12-06" version="1">MNAVKEIAEQEKHNPTRTLRIGCFPSACACILPGIIRYFETYHPQIKIIPYEENSSEIIDSVQNETIDAGFVHFPVTGMYSVPVYQDKFTVVLPDAHPLAKNNAISVEELVGEPLIISKGRYELSIMALFKEKNITPVIKYEFNHPDTAISFIRQGLGIALLPELTLKAVAGELCSVPLEPTFYRQISLLVKEAPVEGSPLFLLQMCMETLVVKGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DV0</accession>
    <name>Q32DV0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SDY_2432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000660231.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403996.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DV0"/>
    <dbReference type="STRING" id="300267.SDY_2432"/>
    <dbReference type="EnsemblBacteria" id="ABB62505">
        <property type="protein sequence ID" value="ABB62505"/>
        <property type="gene ID" value="SDY_2432"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2432"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2930"/>
    <dbReference type="HOGENOM" id="CLU_001265_10_13_6"/>
    <dbReference type="OMA" id="TMFFDLG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="9"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB62505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="396" mass="42906" checksum="AFA299297BE9BC61" modified="2005-12-06" version="1">MKEKLWTKDFWAITIISFIIFFVFYVLLTLLPIYISDRLHASPDKAGLLVTLFLIAAIVIRPFAGQWVGKYSNKTILVLSSLAFLVVTALYPFCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWEAFNMAFWLCTGVAAVGIILSLIMTVPPVISHADGSKPKMGFAAMFDRAALPFAMVTFFMTFSYAGVSAFLALYARELNLMSAASNFLLCYAIFLMICRTFTGNVCDKKGPKYVVYPCLLFFTVGLVVLGYTQGSVMMVVSGALIGIGYGSVTPVFQTQIISSVEPHKIGVANSLFFNAMDAGLALGACVMGMMVAHTGYRMIYLLGALLVVVAGGVYALQMKGKSGVALVVAKEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E27</accession>
    <name>Q32E27_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS2 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E27"/>
    <dbReference type="EnsemblBacteria" id="ABB62428">
        <property type="protein sequence ID" value="ABB62428"/>
        <property type="gene ID" value="SDY_2351"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2351"/>
    <dbReference type="HOGENOM" id="CLU_052819_0_0_6"/>
    <dbReference type="OMA" id="EIAAPCR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="279" mass="32157" checksum="81A1730446C2CD73" modified="2005-12-06" version="1">MSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIRELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFVLDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E84</accession>
    <name>Q32E84_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS911 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E84"/>
    <dbReference type="STRING" id="300267.SDY_2294"/>
    <dbReference type="EnsemblBacteria" id="ABB62371">
        <property type="protein sequence ID" value="ABB62371"/>
        <property type="gene ID" value="SDY_2294"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2294"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_1_6"/>
    <dbReference type="OMA" id="SHYTIRN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038965">
        <property type="entry name" value="InsF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46889:SF1">
        <property type="entry name" value="PTHR46889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="166" mass="19549" checksum="003421980962F9C2" modified="2005-12-06" version="1">MTEPNQVWCGDVTYIWTGKRWAYLAVVLDLFARKPVGWAMSFSPDSRLTMKALEMAWETRGKPGGVMFHSDQGSHYTSRQFRQLLWRYQIRQSMSRRGNCWDNSPMERFFRSLKNEWMPVVGYVSFSEAAHAITDYIVGYYSALRPHEYNGGLPPNESENRYWKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E96</accession>
    <name>Q32E96_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E96"/>
    <dbReference type="EnsemblBacteria" id="ABB62359">
        <property type="protein sequence ID" value="ABB62359"/>
        <property type="gene ID" value="SDY_2282"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2282"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="86" mass="9518" checksum="DADBE3F0B8FB4006" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITSIPITASYYVYDTNKVKSSALEATALINVKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EC7</accession>
    <name>Q32EC7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator cys regulon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbl</name>
        <name evidence="3" type="ordered locus">SDY_2246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001011001.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403819.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EC7"/>
    <dbReference type="STRING" id="300267.SDY_2246"/>
    <dbReference type="EnsemblBacteria" id="ABB62328">
        <property type="protein sequence ID" value="ABB62328"/>
        <property type="gene ID" value="SDY_2246"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2246"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2715"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_6"/>
    <dbReference type="OMA" id="ITYDNAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08444">
        <property type="entry name" value="PBP2_Cbl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037408">
        <property type="entry name" value="Cbl_PBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="316" mass="35862" checksum="EDAA3928E7C9D237" modified="2005-12-06" version="1">MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNVRRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGTPQEIATLLHNGEADIGIASERLSNDPQLVAFPWFRWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRIDDAFAHKGLLADIVLSAQDSDVIKTYVALGLGIGLVAEQSSGEQEEKNLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ED6</accession>
    <name>Q32ED6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yeeA</name>
        <name evidence="2" type="ordered locus">SDY_2236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001200870.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403810.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ED6"/>
    <dbReference type="STRING" id="300267.SDY_2236"/>
    <dbReference type="EnsemblBacteria" id="ABB62319">
        <property type="protein sequence ID" value="ABB62319"/>
        <property type="gene ID" value="SDY_2236"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2236"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2705"/>
    <dbReference type="HOGENOM" id="CLU_064722_0_0_6"/>
    <dbReference type="OMA" id="PHGEWAS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006726">
        <property type="entry name" value="PHBA_efflux_AaeB/fusaric-R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04632">
        <property type="entry name" value="FUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="352" mass="39960" checksum="7F172A524D8F6CF9" modified="2005-12-06" version="1">MRADKSLSPFEIRVYRHYRIVHGTRVALAFLLTFLIIRLFTIPESSWPLVTMVVIMGPISFWGNVVPRAFERIGGTVLGSILGLIALQLELISLPLMLVWCAAAMFLCGWLALGKKPYQGLLIGVTLAIVVGSPTGEIDTALWRSGDVILGSLLAMLFTGIWPQRAFIHWRIQLAKSLTEYNRVYQSAFSPNLLERPRLESHLQKLLTDAVKMRGLIAPASKETRIPKSIYEGIQTINRNLVCMLELQINAYWATRPSHFVLLNAQKLRDTQHMMQQILLSLVHALYEGNPQPVFANTEKLNDAVEELRQLLNNHHDLKVVETPIYGYVWLNMETARQLELLSNLICRALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EJ6</accession>
    <name>Q32EJ6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021809.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EJ6"/>
    <dbReference type="STRING" id="300267.SDY_2173"/>
    <dbReference type="EnsemblBacteria" id="ABB62259">
        <property type="protein sequence ID" value="ABB62259"/>
        <property type="gene ID" value="SDY_2173"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2173"/>
    <dbReference type="HOGENOM" id="CLU_046671_0_0_6"/>
    <dbReference type="OMA" id="ARNQLAC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="352" mass="38077" checksum="91104F3BCCCA4CBB" modified="2005-12-06" version="1">MLHRLAILEIPGIVRQQGSTLTLAGNGEERWKLTRPLSQHAALIEAACFGATLQEAARHKLEADMLDAGGIGSITTCLSQAALAGLASFSQQLLEQLTLLIAQENQFAEMGQALEVLYALWRLDEISGMQGAQILQTTLCAAIDRTLWLCESNGRPDEKEFHAHLHSWQALCHILRDLHSGVNLPGVSLSAAVALLERRSQAIHAPALDRGAALGALMRLEHPNASAEAALTMLAQLSPAQSGEALHGLLALARNQLACQPAFIAGFSSHLNQLSDANFINALPDLRAAMAWLPPRERGTLAHQVLEHYQLAQLPVSALQMPLHCPPQAIAHHQQLEQQALASLQNWGVFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EU1</accession>
    <name>Q32EU1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidoglycan hydrolase FlgJ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Muramidase FlgJ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">flgJ</name>
        <name evidence="11" type="ordered locus">SDY_2070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the glycosyl hydrolase 73 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FlgJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001323587.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403655.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EU1"/>
    <dbReference type="STRING" id="300267.SDY_2070"/>
    <dbReference type="CAZy" id="GH73">
        <property type="family name" value="Glycoside Hydrolase Family 73"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62164">
        <property type="protein sequence ID" value="ABB62164"/>
        <property type="gene ID" value="SDY_2070"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2070"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2486"/>
    <dbReference type="HOGENOM" id="CLU_013771_3_0_6"/>
    <dbReference type="OMA" id="EGVFVQM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019301">
        <property type="entry name" value="Flagellar_prot_FlgJ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013377">
        <property type="entry name" value="FlaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10135">
        <property type="entry name" value="Rod-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02541">
        <property type="entry name" value="flagell_FlgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYZ2" evidence="10">
        <location>
            <begin position="142"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB62164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="313" mass="34485" checksum="2A21A741A4192D81" modified="2005-12-06" version="1">MISDSKLLASAAWDAQSLNELKAKAGEDPAANIRPVARQVEGMFVQMMLKSMRDALPKDGLFSSEHTRLYTSMYDQQIAQQMTAGKGLGLAEMMVKQMTPEQPLPEEPTPAAPMKFPLETVVRYQNQALSQLVQKAVPRNYDDSLPGDSKAFLAQLSLPAQLASQQSGVPHHLILAQAALESGWGQRQIRRENGEPSYNLFGVKASGNWKGPVTEITTTEYENGEAKKVKAKFRVYSSYLEALSDYVGLLTRNPRYAAVTTAASAEQGAQALQDAGYATDPHYARKLTNMIQQMKSISDKVSKTYSMNIDNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F50</accession>
    <name>Q32F50_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative outer membrane receptor for iron transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_1954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F50"/>
    <dbReference type="STRING" id="300267.SDY_1954"/>
    <dbReference type="EnsemblBacteria" id="ABB62055">
        <property type="protein sequence ID" value="ABB62055"/>
        <property type="gene ID" value="SDY_1954"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1954"/>
    <dbReference type="HOGENOM" id="CLU_008287_13_0_6"/>
    <dbReference type="OMA" id="DTRWTHR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="204"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB62055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="513" mass="56678" checksum="2C197D85F32F3A17" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F53</accession>
    <name>Q32F53_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000598847.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403543.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F53"/>
    <dbReference type="STRING" id="300267.SDY_1951"/>
    <dbReference type="EnsemblBacteria" id="ABB62052">
        <property type="protein sequence ID" value="ABB62052"/>
        <property type="gene ID" value="SDY_1951"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1951"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2356"/>
    <dbReference type="HOGENOM" id="CLU_011226_6_5_6"/>
    <dbReference type="OMA" id="YIAANCY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="83"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="202" mass="23056" checksum="47B7CA677771C8E3" modified="2005-12-06" version="1">MIKVYGVPGWGSTISELMADIPYQFVDVSGFDHEGTSRELLKTLNPLCQVPTLALENDEMMTETAAIALMVLDRRPDLAPPVGRAERQQFQRLLVWLVANVYPTFTFADYPERWAPDAPEQLKKNVIEYRKSLYIWLNSQLTAEPYAFGEQLTLVDCYLCTMRTWGPGHEWFQDNATNISAIADAVCQLPKLQEVLKRNEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F61</accession>
    <name>Q32F61_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pspB</name>
        <name evidence="3" type="ordered locus">SDY_1939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001274963.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403535.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F61"/>
    <dbReference type="SMR" id="Q32F61"/>
    <dbReference type="STRING" id="300267.SDY_1939"/>
    <dbReference type="EnsemblBacteria" id="ABB62044">
        <property type="protein sequence ID" value="ABB62044"/>
        <property type="gene ID" value="SDY_1939"/>
    </dbReference>
    <dbReference type="GeneID" id="66674867"/>
    <dbReference type="KEGG" id="sdy:SDY_1939"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2338"/>
    <dbReference type="HOGENOM" id="CLU_178570_0_0_6"/>
    <dbReference type="OMA" id="LWLHYSQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009271">
        <property type="term" value="P:phage shock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009554">
        <property type="entry name" value="Phageshock_PspB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06667">
        <property type="entry name" value="PspB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02976">
        <property type="entry name" value="phageshock_pspB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="74" mass="8763" checksum="22B82DF367099A1B" modified="2005-12-06" version="1">MSALFLAIPLTIFVLFVLPIWLWLHYSNRSGRSELSQSEQQRLAQLADEAKRMRERIQALESILDAEHPNWRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F85</accession>
    <name>Q32F85_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ynhE</name>
        <name evidence="2" type="ordered locus">SDY_1914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F85"/>
    <dbReference type="STRING" id="300267.SDY_1914"/>
    <dbReference type="EnsemblBacteria" id="ABB62020">
        <property type="protein sequence ID" value="ABB62020"/>
        <property type="gene ID" value="SDY_1914"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1914"/>
    <dbReference type="HOGENOM" id="CLU_026231_4_0_6"/>
    <dbReference type="OMA" id="HIECDAI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="255" mass="27834" checksum="7D422B131160210E" modified="2005-12-06" version="1">MADEDSYVSYIEGCSAPVRDSYQLHAAVVEVTIHKNAEVKYSTVQNWFPGDNNTGGILNFVTKCALCEGENSKMSWTQSETGSAITWKYPSCILRGDNSIGEFYSVALTSGHQQADTGTKMIHIGKNTKSTIISKGISAGHSQNSYRGLVKIMPTATNARNFTQCDSMLIGANCGAHTFPYVECRNNSAQLEHEATTSRIGEDQLFYCLQRGSSEEDAISMIVNGFCKDVFSELPLEFAVEAQKLLAISLEHSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F94</accession>
    <name>Q32F94_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pykF</name>
        <name evidence="15" type="ordered locus">SDY_1905</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378751.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403502.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F94"/>
    <dbReference type="STRING" id="300267.SDY_1905"/>
    <dbReference type="EnsemblBacteria" id="ABB62011">
        <property type="protein sequence ID" value="ABB62011"/>
        <property type="gene ID" value="SDY_1905"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1905"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2293"/>
    <dbReference type="HOGENOM" id="CLU_015439_0_0_6"/>
    <dbReference type="OMA" id="MVRVHHL"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB62011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="470" mass="50717" checksum="3440892B90327D90" modified="2005-12-06" version="1">MKKTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAAILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNTVLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLEFNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVPQLVKETTSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FC7</accession>
    <name>Q32FC7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FC7"/>
    <dbReference type="STRING" id="300267.SDY_1869"/>
    <dbReference type="EnsemblBacteria" id="ABB61978">
        <property type="protein sequence ID" value="ABB61978"/>
        <property type="gene ID" value="SDY_1869"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1869"/>
    <dbReference type="HOGENOM" id="CLU_013927_3_0_6"/>
    <dbReference type="OMA" id="GCAFTIT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006726">
        <property type="entry name" value="PHBA_efflux_AaeB/fusaric-R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04632">
        <property type="entry name" value="FUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="535" mass="60555" checksum="6B17EB54021DC330" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FE3</accession>
    <name>RSXD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ion-translocating oxidoreductase complex subunit D</fullName>
            <ecNumber evidence="1">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Rsx electron transport complex subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsxD</name>
        <name type="ordered locus">SDY_1853</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NqrB/RnfD family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000231916.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403453.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FE3"/>
    <dbReference type="SMR" id="Q32FE3"/>
    <dbReference type="STRING" id="300267.SDY_1853"/>
    <dbReference type="EnsemblBacteria" id="ABB61962">
        <property type="protein sequence ID" value="ABB61962"/>
        <property type="gene ID" value="SDY_1853"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1853"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2232"/>
    <dbReference type="HOGENOM" id="CLU_042020_0_0_6"/>
    <dbReference type="OMA" id="GWQWINL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00462">
        <property type="entry name" value="RsxD_RnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011303">
        <property type="entry name" value="RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578:SF0">
        <property type="entry name" value="PTHR30578:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01946">
        <property type="entry name" value="rnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000298239" description="Ion-translocating oxidoreductase complex subunit D">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00462"/>
        </source>
    </evidence>
    <sequence length="352" mass="38126" checksum="F0F5D1D59A23650F" modified="2005-12-06" version="1">MVFRIASSPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVAATLKDNSALLTGLLLAVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPHEIAVNILGFIDAIQVIFSGHTASGGDMNTLRLGIDGISQATPLDTFKTSVRAGHSVEQIMQYPIYSGILAGAGWQWVNLAWLAGGVWLLWQKAIRWHIPLSFLVTLALCATLGWLFSPETLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWLIRSFGGYPDGVAFAVLLANITVPLIDYYTRPRVYGHRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FI1</accession>
    <name>Q32FI1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">infC</name>
        <name evidence="8" type="ordered locus">SDY_1813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FI1"/>
    <dbReference type="SMR" id="Q32FI1"/>
    <dbReference type="STRING" id="300267.SDY_1813"/>
    <dbReference type="EnsemblBacteria" id="ABB61924">
        <property type="protein sequence ID" value="ABB61924"/>
        <property type="gene ID" value="SDY_1813"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1813"/>
    <dbReference type="HOGENOM" id="CLU_054919_3_2_6"/>
    <dbReference type="OMA" id="RNMIMFL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="55"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB61924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="144" mass="16637" checksum="68C6870186F7F73A" modified="2005-12-06" version="1">MSLREALEKAEEAGVDLVEISPNAEPPVCRIMDYGKFLYEKSKSSKEQKKKQKVIQVKEIKFRPGTDEGDYQVKLRSLIRFLEEGDKAKITLRFRGREMAHQQIGMEVLNRVKDDLQELAVVESFPTKIEGRQMIMVLAPKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FU4</accession>
    <name>Q32FU4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yeaO</name>
        <name evidence="1" type="ordered locus">SDY_1690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403302.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FU4"/>
    <dbReference type="STRING" id="300267.SDY_1690"/>
    <dbReference type="EnsemblBacteria" id="ABB61811">
        <property type="protein sequence ID" value="ABB61811"/>
        <property type="gene ID" value="SDY_1690"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1690"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2037"/>
    <dbReference type="HOGENOM" id="CLU_137928_1_0_6"/>
    <dbReference type="OMA" id="AHPEHWW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="122" mass="14171" checksum="1C63F86E45597255" modified="2005-12-06" version="1">MKGRTNTMNIQCKRVYDPAEQSDGYRILVDRLWPRGIKKTDLALDEWNKEITPSTELRKAFHGEVVDFATFREQYRAELAQHEQEGKRLADIAKKQPLTLLYSAKNTTQNHALVLADWLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G52</accession>
    <name>Q32G52_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403194.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G52"/>
    <dbReference type="STRING" id="300267.SDY_1570"/>
    <dbReference type="EnsemblBacteria" id="ABB61703">
        <property type="protein sequence ID" value="ABB61703"/>
        <property type="gene ID" value="SDY_1570"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1570"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1886"/>
    <dbReference type="HOGENOM" id="CLU_155120_0_0_6"/>
    <dbReference type="OMA" id="CANDTFK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010595">
        <property type="entry name" value="DUF1161"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06649">
        <property type="entry name" value="DUF1161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220965" evidence="2">
        <location>
            <begin position="36"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="115" mass="12270" checksum="15B4DAB943A3EDFE" modified="2005-12-06" version="1">MLCLKKLSSRKELMMKLSTCCAALLLALSSPTVLAAPGSCERIQSDISQRIINNGVPESSFTLSIVPNDQVDQPDSQVVGHCANDTHKILYTRTTSGNVSAPTQSNQDGVPAEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GF4</accession>
    <name>Q32GF4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative oxidoreductase, Fe-S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ydbK</name>
        <name evidence="14" type="ordered locus">SDY_1461</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000628189.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403092.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GF4"/>
    <dbReference type="STRING" id="300267.SDY_1461"/>
    <dbReference type="EnsemblBacteria" id="ABB61601">
        <property type="protein sequence ID" value="ABB61601"/>
        <property type="gene ID" value="SDY_1461"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1461"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1741"/>
    <dbReference type="HOGENOM" id="CLU_002569_0_0_6"/>
    <dbReference type="OMA" id="NTVMQVC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000159">
        <property type="entry name" value="NifJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="680"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
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</entry>
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                <person name="Yang J."/>
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                <person name="Yan Y."/>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
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                <person name="Tang X."/>
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                <person name="Wang Y."/>
                <person name="Yuan Z."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABB61469.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
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    </evidence>
    <sequence length="71" mass="8391" checksum="07AB8392AB18EDC0" modified="2005-12-06" version="1">MAASPDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
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    <accession>Q32H24</accession>
    <name>NHAP2_SHIDS</name>
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        </alternativeName>
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        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
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                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29467"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29468"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB61381" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61381.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000340211.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402872.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H24"/>
    <dbReference type="SMR" id="Q32H24"/>
    <dbReference type="STRING" id="300267.SDY_1230"/>
    <dbReference type="EnsemblBacteria" id="ABB61381">
        <property type="protein sequence ID" value="ABB61381"/>
        <property type="gene ID" value="SDY_1230"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1230"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1460"/>
    <dbReference type="HOGENOM" id="CLU_005912_9_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01075">
        <property type="entry name" value="NhaP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023729">
        <property type="entry name" value="NhaP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000278152" description="K(+)/H(+) antiporter NhaP2">
        <location>
            <begin position="1"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="403"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="578" mass="62235" checksum="6A150D62119E07D7" modified="2007-02-20" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H70</accession>
    <name>Q32H70_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yecM</name>
        <name evidence="1" type="ordered locus">SDY_1179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402826.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H70"/>
    <dbReference type="STRING" id="300267.SDY_1179"/>
    <dbReference type="EnsemblBacteria" id="ABB61335">
        <property type="protein sequence ID" value="ABB61335"/>
        <property type="gene ID" value="SDY_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1179"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1393"/>
    <dbReference type="HOGENOM" id="CLU_122770_0_0_6"/>
    <dbReference type="OMA" id="SFAQADH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07268">
        <property type="entry name" value="VOC_EcYecM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010393">
        <property type="entry name" value="DUF991"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37519">
        <property type="entry name" value="PTHR37519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06185">
        <property type="entry name" value="YecM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="190" mass="21394" checksum="7AD7B8B2DE536CF8" modified="2005-12-06" version="1">MIMANWQSIDELQDIASDLPRFTHALDELSRRLGLDITPLTADHISLRCHQNATAERWRRGFEQCGELLSENMINGRPICLFKLHEPVQVAHWQCSIVELPWPGEKRYPHEGWEHIEIVLPGDPETLNARALALLSDEGLSLPGISVKTSSPKGEHERLPNPTLAVTDGKTTIKFHPWSIEEIVASEQSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H79</accession>
    <name>CMOA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxy-S-adenosyl-L-methionine synthase</fullName>
            <shortName evidence="1">Cx-SAM synthase</shortName>
            <ecNumber evidence="1">2.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cmoA</name>
        <name type="ordered locus">SDY_1169</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000019588.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402817.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H79"/>
    <dbReference type="SMR" id="Q32H79"/>
    <dbReference type="STRING" id="300267.SDY_1169"/>
    <dbReference type="EnsemblBacteria" id="ABB61326">
        <property type="protein sequence ID" value="ABB61326"/>
        <property type="gene ID" value="SDY_1169"/>
    </dbReference>
    <dbReference type="GeneID" id="66674239"/>
    <dbReference type="KEGG" id="sdy:SDY_1169"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1377"/>
    <dbReference type="HOGENOM" id="CLU_078475_0_0_6"/>
    <dbReference type="OMA" id="MIELYYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01589">
        <property type="entry name" value="Cx_SAM_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005271">
        <property type="entry name" value="CmoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF2">
        <property type="entry name" value="PTHR43861:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006325">
        <property type="entry name" value="MeTrfase_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00740">
        <property type="entry name" value="TIGR00740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000314388" description="Carboxy-S-adenosyl-L-methionine synthase">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01589"/>
        </source>
    </evidence>
    <sequence length="247" mass="27791" checksum="2930565165A0A7F4" modified="2005-12-06" version="1">MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPGTQVYDLGCSLGAATLSVRRNIHHDNCKIIAIDNSPAMIERCRRHIDAYKAPTPVDVIEGDIRDIAIENASMVVLNFTLQFLEPSERQALLDKIYQGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLHKAGFEHSELWFQCFNFGSLVALKAEDAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H98</accession>
    <name>RUVC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="1">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvC</name>
        <name type="ordered locus">SDY_1150</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295503.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402798.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H98"/>
    <dbReference type="SMR" id="Q32H98"/>
    <dbReference type="STRING" id="300267.SDY_1150"/>
    <dbReference type="EnsemblBacteria" id="ABB61307">
        <property type="protein sequence ID" value="ABB61307"/>
        <property type="gene ID" value="SDY_1150"/>
    </dbReference>
    <dbReference type="GeneID" id="66674246"/>
    <dbReference type="KEGG" id="sdy:SDY_1150"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1354"/>
    <dbReference type="HOGENOM" id="CLU_091257_2_1_6"/>
    <dbReference type="OMA" id="AICHIWR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000225177" description="Crossover junction endodeoxyribonuclease RuvC">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <sequence length="173" mass="18747" checksum="2170DCFA4AD43FE1" modified="2005-12-06" version="1">MAIILGIDPGSRVTGYGVIRQVGRQLSYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNAMQMSESRLNLARGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HA7</accession>
    <name>Q32HA7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pykA</name>
        <name evidence="15" type="ordered locus">SDY_1141</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000091154.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402789.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HA7"/>
    <dbReference type="STRING" id="300267.SDY_1141"/>
    <dbReference type="EnsemblBacteria" id="ABB61298">
        <property type="protein sequence ID" value="ABB61298"/>
        <property type="gene ID" value="SDY_1141"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1141"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1344"/>
    <dbReference type="HOGENOM" id="CLU_015439_8_0_6"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="6"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="363"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB61298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="480" mass="51387" checksum="C37050B9374977AC" modified="2005-12-06" version="1">MSRRLRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIKTAALIGVDYLAVSFPRCGEDLNYARRLTRDAGCDAKIVAKVERAEAVCSQDAMDDIILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEKIPSINVSKHRLDVQFDNVEEAIAMSAMYAANHLKGVTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVHFDSANDGVAAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRILTVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HD9</accession>
    <name>PGSA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="2">2.7.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Phosphatidylglycerophosphate synthase</fullName>
            <shortName evidence="2">PGP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pgsA</name>
        <name type="ordered locus">SDY_1106</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001160187.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402757.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HD9"/>
    <dbReference type="SMR" id="Q32HD9"/>
    <dbReference type="STRING" id="300267.SDY_1106"/>
    <dbReference type="EnsemblBacteria" id="ABB61266">
        <property type="protein sequence ID" value="ABB61266"/>
        <property type="gene ID" value="SDY_1106"/>
    </dbReference>
    <dbReference type="GeneID" id="67415812"/>
    <dbReference type="KEGG" id="sdy:SDY_1106"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1303"/>
    <dbReference type="HOGENOM" id="CLU_051314_2_1_6"/>
    <dbReference type="OMA" id="WSMVYYL"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01437">
        <property type="entry name" value="PgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023762">
        <property type="entry name" value="PGP_synthase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000239130" description="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="2"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="82"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01437"/>
        </source>
    </evidence>
    <sequence length="182" mass="20701" checksum="F8F0502ABE6DC8D5" modified="2007-01-23" version="3">MQFNIPTLLTLFRVILIPFFVLVFYLPVTWSPFAAALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVLVAIAMVLVTEHYHSWWVTLPAATMIAREIIISALREWMAELGKRSSVAVSWIGKVKTTAQMVALAWLLWRPNIWVEYAGIALFFVAAVLTLWSMLQYLSAARADLLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HJ6</accession>
    <name>Q32HJ6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yedJ</name>
        <name evidence="2" type="ordered locus">SDY_1044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HJ6"/>
    <dbReference type="STRING" id="300267.SDY_1044"/>
    <dbReference type="EnsemblBacteria" id="ABB61209">
        <property type="protein sequence ID" value="ABB61209"/>
        <property type="gene ID" value="SDY_1044"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1044"/>
    <dbReference type="HOGENOM" id="CLU_036524_4_1_6"/>
    <dbReference type="OMA" id="RINQVCH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="142" mass="15287" checksum="95670AFC196E9075" modified="2005-12-06" version="1">MQFPADKIEAVCHAIAAHSFSAQIAPLTTEAKIVQDADRLEALGAIGLARVFAVSGALGVALFDGEDPFAQHRPLDDKRYALDHFQTKLLKLPHTMQTIRGKQLAQHNAQFLVEFMAKLSAELAGGNEGVDHKVIDAFSPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HU3</accession>
    <name>Q32HU3_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylglyoxal synthase</fullName>
            <shortName evidence="2">MGS</shortName>
            <ecNumber evidence="2">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">mgsA</name>
        <name evidence="5" type="ordered locus">SDY_0938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HU3"/>
    <dbReference type="STRING" id="300267.SDY_0938"/>
    <dbReference type="EnsemblBacteria" id="ABB61112">
        <property type="protein sequence ID" value="ABB61112"/>
        <property type="gene ID" value="SDY_0938"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0938"/>
    <dbReference type="HOGENOM" id="CLU_120420_0_1_6"/>
    <dbReference type="OMA" id="RACDVHN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018148">
        <property type="entry name" value="Methylglyoxal_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01335">
        <property type="entry name" value="METHYLGLYOXAL_SYNTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2 3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006614-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB61112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="155" mass="17326" checksum="A9F587D71CA137E5" modified="2005-12-06" version="1">MYIMELTTRTLPARKHIALVAHDHCKQMLMSWVERHQPLLEQHVLYATGTTGNLISRATGMNVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNVATADFIIQSPHFNDAVDILIPDYQRYLADRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HW4</accession>
    <name>Q32HW4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fimbrial-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402582.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HW4"/>
    <dbReference type="STRING" id="300267.SDY_0915"/>
    <dbReference type="EnsemblBacteria" id="ABB61091">
        <property type="protein sequence ID" value="ABB61091"/>
        <property type="gene ID" value="SDY_0915"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0915"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1061"/>
    <dbReference type="HOGENOM" id="CLU_088965_0_1_6"/>
    <dbReference type="OMA" id="NLEGCPT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000259">
        <property type="entry name" value="Adhesion_dom_fimbrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00419">
        <property type="entry name" value="Fimbrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fimbrial" evidence="1">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="169" mass="17639" checksum="00A54AFDD7DEE860" modified="2005-12-06" version="1">MFFSILNIHVGMAGPEQVSMHIYGNVVDQGCDVATKSALQNIHIGDFNISDFQAANTVSTAADLNIDITGCAAGITGADVLFSGEADTLAPTLLKLTDTGGSGGMATGIAVQILDAQSQQEIPLNQVQPLTPLKAGDNTLKYQLRYKSTKAGATGGNATVVLYFDLVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HX2</accession>
    <name>Q32HX2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yeiQ</name>
        <name evidence="4" type="ordered locus">SDY_0907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001091935.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HX2"/>
    <dbReference type="STRING" id="300267.SDY_0907"/>
    <dbReference type="EnsemblBacteria" id="ABB61083">
        <property type="protein sequence ID" value="ABB61083"/>
        <property type="gene ID" value="SDY_0907"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0907"/>
    <dbReference type="HOGENOM" id="CLU_027324_0_1_6"/>
    <dbReference type="OMA" id="PWEQMKL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023027">
        <property type="entry name" value="Mannitol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00974">
        <property type="entry name" value="MANNITOL_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="2">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="3">
        <location>
            <begin position="216"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="469" mass="51828" checksum="70F4E53258E34EAB" modified="2005-12-06" version="1">MNTIASVTLPHHVHAPRYDRQQLQSRIVHFGFGAFHRAHQALLTDRVLNAQGGDWGICEISLFSGDQLMSQLRAQNHLYTVLEKGADGNQAIIVGAVHECLNAKLDSLAAIIEKFCEPQVAIVSLTITEKGYCIDPATGALDTSNPRIIHDLQTPEEPHSAPGILVEALKRRRERGLTPFTVLSCDNIPDNGHVVKNAVLGMAEKRSPELAGWIKEHVSFPGTMVDRIVPAATDESLAEISQHLGVNDPCAISCEPFIQWVVEDNFVAGRPVWEVAGVQMVNDVLPWEEMKLRMLNGSHSFLAYLGYLSGFAHISDCMQDRAFRHAARTLMLDEQALTLRIKDVDLTQYADKLIARFANPALKHKTWQIAMDGSQKLPQRMLAGIRIHLGRETDWSLLALGVAGWMRYVSGVDDAGNAIDVRDPLSDKIRDLVAGSSSEQRVTALLSLREVFGDDLPDNPHFVQAIEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HZ8</accession>
    <name>Q32HZ8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Heme exporter protein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ccmD</name>
        <name evidence="12" type="ordered locus">SDY_0880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell inner membrane</location>
            <topology evidence="3 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the CcmD/CycX/HelD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000186540.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402548.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HZ8"/>
    <dbReference type="SMR" id="Q32HZ8"/>
    <dbReference type="STRING" id="300267.SDY_0880"/>
    <dbReference type="EnsemblBacteria" id="ABB61057">
        <property type="protein sequence ID" value="ABB61057"/>
        <property type="gene ID" value="SDY_0880"/>
    </dbReference>
    <dbReference type="GeneID" id="67416634"/>
    <dbReference type="KEGG" id="sdy:SDY_0880"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1015"/>
    <dbReference type="HOGENOM" id="CLU_180892_0_0_6"/>
    <dbReference type="OMA" id="MFFQSWS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007078">
        <property type="entry name" value="Haem_export_protD_CcmD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04995">
        <property type="entry name" value="CcmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03141">
        <property type="entry name" value="cytochro_ccmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB61057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="7745" checksum="BEC1D341EEADA018" modified="2005-12-06" version="1">MTPAFASWNEFFAMGGYAFFVWLAVVMTVIPLVVLVVHSVMQHRAILRGVAQQRAREARLRAAQQQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I57</accession>
    <name>Q32I57_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I57"/>
    <dbReference type="STRING" id="300267.SDY_0818"/>
    <dbReference type="EnsemblBacteria" id="ABB61000">
        <property type="protein sequence ID" value="ABB61000"/>
        <property type="gene ID" value="SDY_0818"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0818"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="145" mass="16807" checksum="B1AF12D549921BF0" modified="2005-12-06" version="1">MPKRITSSPVAHADVALICELDEQWSFVGSKARQHWLWYAYNTKTGGVPAYTFGPRTDETCRELLALLTPFNIGMITSDDWGSYGREVPKDKHLTGKIFTQRIERNNLTLRTRIKRLARKTICFSRSVEIHEKVIGTFIEKHMFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IB8</accession>
    <name>GSID_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione transport system permease protein GsiD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gsiD</name>
        <name type="ordered locus">SDY_0755</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001236050.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402428.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IB8"/>
    <dbReference type="STRING" id="300267.SDY_0755"/>
    <dbReference type="EnsemblBacteria" id="ABB60939">
        <property type="protein sequence ID" value="ABB60939"/>
        <property type="gene ID" value="SDY_0755"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0755"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.869"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_6"/>
    <dbReference type="OMA" id="RAWWVVS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000280013" description="Glutathione transport system permease protein GsiD">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="3">
        <location>
            <begin position="101"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P75799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="303" mass="33267" checksum="94586DC77A303FDC" modified="2005-12-06" version="1">MRLFNWRRQAVLNAMPLVKPDQVRTPWHEFWRRFRRQHMAMTAALFVILLIVVAIFARWIAPYDAENYFDYDNLNNGPSLQHWFGVDSLGRDIFSRVLVGAQISLAAGVFAVFIGAAIGTLLGLLAGYYEGWWDRLIMRICDVLFAFPGILLAIAVVAVLGSGIANVIIAVAIFSIPAFARLVRGNTLVLKQQTFIESARSIGASDMTVLLRHILPGTVSSIVVFFTMRIGTSIISAASLSFLGLGAQPPTPEWGAMLDEARADMVIAPHVAVFPVLAIFLTVLAFNLLGDGLRDALDPKIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ID2</accession>
    <name>Q32ID2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putrescine-binding periplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">potF</name>
        <name evidence="4" type="ordered locus">SDY_0741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for the activity of the bacterial periplasmic transport system of putrescine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the bacterial solute-binding protein PotD/PotF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000126081.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402414.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ID2"/>
    <dbReference type="STRING" id="300267.SDY_0741"/>
    <dbReference type="EnsemblBacteria" id="ABB60925">
        <property type="protein sequence ID" value="ABB60925"/>
        <property type="gene ID" value="SDY_0741"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0741"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.855"/>
    <dbReference type="HOGENOM" id="CLU_026974_1_4_6"/>
    <dbReference type="OMA" id="SNWTEYM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221122" description="Putrescine-binding periplasmic protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR019574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="370" mass="40842" checksum="1D84165CEECE0764" modified="2005-12-06" version="1">MTALNKKWLSGLVAGALMAVSVGTLAAEQKTLHIYNWSDYIAPDTVANFEKETGIKVVYDVFDSNEVLEGKLMAGSTGFDLVVPSASFLERQLTAGVFQPLDKSKLPEWKNLDPELLKLVAKHDPDNKFAMPYMWATTGIGYNVDKVKAVLGENAPVDSWDLILKPENLEKLKSCGVSFLDAPEEVFATVLNYLGKDPNSTKADDYTGPATDLLLKLRPNIRYFHSSQYINDLANGDICVAIGWAGDVWQASNRAKEANNGVNVSFSIPKEGAMAFFDVFAMPADAKNKDEAYQFLNYLLRPDVVAHISDHVFYANANKTATPLVSAEVRDNPGIYPPADVRAKLFTLKVQDPKIDRVRTRAWTKVKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IH6</accession>
    <name>Q32IH6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc transporter ZitB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybgR</name>
        <name evidence="6" type="synonym">zitB</name>
        <name evidence="7" type="ordered locus">SDY_0696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000951292.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402370.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IH6"/>
    <dbReference type="SMR" id="Q32IH6"/>
    <dbReference type="STRING" id="300267.SDY_0696"/>
    <dbReference type="EnsemblBacteria" id="ABB60881">
        <property type="protein sequence ID" value="ABB60881"/>
        <property type="gene ID" value="SDY_0696"/>
    </dbReference>
    <dbReference type="GeneID" id="66670977"/>
    <dbReference type="KEGG" id="sdy:SDY_0696"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.807"/>
    <dbReference type="HOGENOM" id="CLU_013430_0_0_6"/>
    <dbReference type="OMA" id="GHEKMLH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00552">
        <property type="entry name" value="ZitB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023500">
        <property type="entry name" value="Zn_transptr_ZitB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="313" mass="34678" checksum="36740D67EABAC907" modified="2005-12-06" version="1">MAHSHSHTSSHLPEDNNARRLLYAFGVTAGFMLVEVVGGFLSGSLALLADAGHMLTDTAALLFALLAVQFSRRPPTIRHTFGWLRLTTLAAFVNAIALVVITILIVWEAIERFRTPRPVEGGMMMAIAVAGLLANILSFWLLHHGSEEKNLNVRAAALHVLGDLLGSVGAIIAALIIIWTGWTPADPILSILVSLLVLRSAWRLLKDSVNELLEGAPVSLDIAELKRRMCREIPEVRNVHHVHVWMVGEKPVMTLHVQVIPPHDHDALLDQIQHYLMDHYQIEHATIQMEYQPCHGPDCHLNEGVSGHSHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IU3</accession>
    <name>Q32IU3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybeB</name>
        <name evidence="2" type="ordered locus">SDY_0559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IU3"/>
    <dbReference type="STRING" id="300267.SDY_0559"/>
    <dbReference type="EnsemblBacteria" id="ABB60764">
        <property type="protein sequence ID" value="ABB60764"/>
        <property type="gene ID" value="SDY_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0559"/>
    <dbReference type="HOGENOM" id="CLU_092688_5_2_6"/>
    <dbReference type="OMA" id="VIVHIFK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="7678" checksum="A470FC77D9207E12" modified="2005-12-06" version="1">MIICTGTSSRHVMSIADHVVQESRAAGLLPLGVEGENSADWIVVDLGDVIVHVMQEESRRLYELEKLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IY5</accession>
    <name>Q32IY5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent serine activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">entF</name>
        <name evidence="7" type="ordered locus">SDY_0515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000077781.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402211.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IY5"/>
    <dbReference type="STRING" id="300267.SDY_0515"/>
    <dbReference type="ESTHER" id="shifl-entf">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB60722">
        <property type="protein sequence ID" value="ABB60722"/>
        <property type="gene ID" value="SDY_0515"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0515"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.608"/>
    <dbReference type="HOGENOM" id="CLU_000022_2_13_6"/>
    <dbReference type="OMA" id="IISPQAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="971"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="1293" mass="142246" checksum="228258F51F7E6F50" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IZ3</accession>
    <name>Q32IZ3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SDY_0507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IZ3"/>
    <dbReference type="STRING" id="300267.SDY_0507"/>
    <dbReference type="EnsemblBacteria" id="ABB60714">
        <property type="protein sequence ID" value="ABB60714"/>
        <property type="gene ID" value="SDY_0507"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0507"/>
    <dbReference type="HOGENOM" id="CLU_041023_0_0_6"/>
    <dbReference type="OMA" id="PNVFMAY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007895">
        <property type="entry name" value="MASE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05231">
        <property type="entry name" value="MASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="MASE1" evidence="7">
        <location>
            <begin position="11"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="8">
        <location>
            <begin position="316"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="387" mass="43801" checksum="D15449ACF551819A" modified="2005-12-06" version="1">MSRNLRHWVISLFIVLAWGTGWLMLWTLSFYLTNNGQQAVLFLPQGVYLALVILLSRRYWPALVLPPLLMMFWLHSEQLLNGYLMLATPVISLFPALLAQNFWHRFPLYWQRLTLLLATVTAASLLNTALLSPFMSGPIMLPGLTSFTGGVLLTPFVYLIFEFLRQQHRYQLLGLDTHNPPLRTSLIIWCSLFFIIGIGTQIVLSPEIERLLLIVVFLPNVVMAWKFGWQGGVLSGLLGSMMITIARQIGVGFSNLVELEIFLATQALLGTGLGIAISRQQHLALNLHHYRQRLEAELAARRALAEKLIHTEEDTRKNLARELHDEIGQNITAIQIQSQLVKRARDPAQIQSAASQINELARRIHLSTRQLLRQLRPPSALCGCHSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J21</accession>
    <name>XGPT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xanthine-guanine phosphoribosyltransferase</fullName>
            <shortName evidence="1">XGPRT</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
            <ecNumber evidence="1">2.4.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Xanthine phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpt</name>
        <name type="ordered locus">SDY_0479</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:25424"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:25426"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:10800"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.22"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:10802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:17975"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="EC" id="2.4.2.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001291990.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402175.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J21"/>
    <dbReference type="SMR" id="Q32J21"/>
    <dbReference type="STRING" id="300267.SDY_0479"/>
    <dbReference type="EnsemblBacteria" id="ABB60686">
        <property type="protein sequence ID" value="ABB60686"/>
        <property type="gene ID" value="SDY_0479"/>
    </dbReference>
    <dbReference type="GeneID" id="66671444"/>
    <dbReference type="KEGG" id="sdy:SDY_0479"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.564"/>
    <dbReference type="HOGENOM" id="CLU_080904_3_0_6"/>
    <dbReference type="OMA" id="FHRDCRA"/>
    <dbReference type="UniPathway" id="UPA00602">
        <property type="reaction ID" value="UER00658"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00909">
        <property type="reaction ID" value="UER00887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01903">
        <property type="entry name" value="XGPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023747">
        <property type="entry name" value="Xanthine_Guanine_PRibTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39563">
        <property type="entry name" value="PTHR39563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00103">
        <property type="entry name" value="PUR_PYR_PR_TRANSFER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000261020" description="Xanthine-guanine phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>guanine</name>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>guanine</name>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01903"/>
        </source>
    </evidence>
    <sequence length="152" mass="16971" checksum="F0AD813127E7200D" modified="2005-12-06" version="1">MSEKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMGVVFVPPISGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JF9</accession>
    <name>QUEA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="1">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queA</name>
        <name type="ordered locus">SDY_0329</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001266503.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402037.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JF9"/>
    <dbReference type="SMR" id="Q32JF9"/>
    <dbReference type="STRING" id="300267.SDY_0329"/>
    <dbReference type="EnsemblBacteria" id="ABB60548">
        <property type="protein sequence ID" value="ABB60548"/>
        <property type="gene ID" value="SDY_0329"/>
    </dbReference>
    <dbReference type="GeneID" id="66671296"/>
    <dbReference type="KEGG" id="sdy:SDY_0329"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.378"/>
    <dbReference type="HOGENOM" id="CLU_039110_1_0_6"/>
    <dbReference type="OMA" id="YSYGDGM"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000231372" description="S-adenosylmethionine:tRNA ribosyltransferase-isomerase">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <sequence length="356" mass="39431" checksum="47F7F0090812DCF3" modified="2005-12-06" version="1">MRVTDFSFELPESLIAHYPMPERSSCRLLSLDGPTGALTHGTFTDLLDKLNPGDLLVFNNTRVIPARLFGRKASGGKIEVLVERMLDDKRILAHIRASKAPKPGAELLLGDDESINATMTARHGALFEVEFNDERSVLDILNSIGHMPLPPYIDRPDEDADRELYQTVYSEKPGAVAAPTAGLHFDEPLLEKLRAKGVEMAFVTLHVGAGTFQPVRVDTIEDHIMHSEYAEVPQDVVDAVLAAKARGNRVIAVGTTSVRSLESAAQAAKNDLIEPFFDDTQIFIYPGFQYKVVDALVTNFHLPESTLIMLVSAFAGYQHTMNAYKAAVEEKYRFFSYGDAMFITYNPQAINERVGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JJ4</accession>
    <name>CLPX_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpX</name>
        <name type="ordered locus">SDY_0294</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000130305.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402002.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JJ4"/>
    <dbReference type="SMR" id="Q32JJ4"/>
    <dbReference type="STRING" id="300267.SDY_0294"/>
    <dbReference type="EnsemblBacteria" id="ABB60513">
        <property type="protein sequence ID" value="ABB60513"/>
        <property type="gene ID" value="SDY_0294"/>
    </dbReference>
    <dbReference type="GeneID" id="67416487"/>
    <dbReference type="KEGG" id="sdy:SDY_0294"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.339"/>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_6"/>
    <dbReference type="OMA" id="HYKRVQA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000024661" description="ATP-dependent Clp protease ATP-binding subunit ClpX">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="ClpX-type ZB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="120"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <sequence length="424" mass="46356" checksum="9DEF1B0786E42B6F" modified="2005-12-06" version="1">MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRNHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVISHRVETGSGIGFGATVKAKSDKASEGELLAQVEPEDLIKFGLIPEFIGRLPVVATLNELSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIAKKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEKVVIDESVIDGQSKPLLIYGKPEAQQASGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JK8</accession>
    <name>Q32JK8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybcJ</name>
        <name evidence="1" type="ordered locus">SDY_0280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401988.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JK8"/>
    <dbReference type="STRING" id="300267.SDY_0280"/>
    <dbReference type="EnsemblBacteria" id="ABB60499">
        <property type="protein sequence ID" value="ABB60499"/>
        <property type="gene ID" value="SDY_0280"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0280"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.321"/>
    <dbReference type="HOGENOM" id="CLU_1947355_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="129" mass="14093" checksum="97589D97B4BC9160" modified="2005-12-06" version="1">MIHRMSNMATFSLGKHPHVELCDLLKLEGWSESGAQAKIAIAEGQVKVDGAVETRKRCKIVAGQTVSFAGHSVQVVACSLSRPVSTGRFSFQTFALYVPFIHADSIDILPKRPSCQPLLRTPPFPYALV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JQ1</accession>
    <name>GLO2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="1">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glyoxalase II</fullName>
            <shortName evidence="1">Glx II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gloB</name>
        <name type="ordered locus">SDY_0231</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001052711.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401945.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JQ1"/>
    <dbReference type="SMR" id="Q32JQ1"/>
    <dbReference type="STRING" id="300267.SDY_0231"/>
    <dbReference type="EnsemblBacteria" id="ABB60456">
        <property type="protein sequence ID" value="ABB60456"/>
        <property type="gene ID" value="SDY_0231"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0231"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.260"/>
    <dbReference type="HOGENOM" id="CLU_030571_4_1_6"/>
    <dbReference type="OMA" id="NYIWLLQ"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005457">
        <property type="entry name" value="Glx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000309706" description="Hydroxyacylglutathione hydrolase">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01374"/>
        </source>
    </evidence>
    <sequence length="251" mass="28458" checksum="8EF5996F71294D8E" modified="2005-12-06" version="1">MNLNSIPAFDDNYIWVLNDEAGRCLIVDPGDAEPVLNAIAANNWQPEAIFLTHHHHDHVGGVKELVEKFPQIVVYGPQETQDKGTTQVVKDGETAFVLGHEFSVIATPGHTLGHICYFSKPYLFCGDTLFSGGCGRLFEGTASQMYQSLKKLSALPDDTLVCCAHEYTLSNMEFALSILPHDLSINDYYRKVKELRAKNQITQPVILKNERQINVFLRTEHIDLINVINEETLLQQPDERFAWLRSKKDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JR2</accession>
    <name>Q32JR2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TsaA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yaeB</name>
        <name evidence="4" type="ordered locus">SDY_0214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000094004.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401934.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JR2"/>
    <dbReference type="STRING" id="300267.SDY_0214"/>
    <dbReference type="EnsemblBacteria" id="ABB60445">
        <property type="protein sequence ID" value="ABB60445"/>
        <property type="gene ID" value="SDY_0214"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0214"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.248"/>
    <dbReference type="HOGENOM" id="CLU_013458_3_0_6"/>
    <dbReference type="OMA" id="CFKEKFA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041369">
        <property type="entry name" value="TrmO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023368">
        <property type="entry name" value="UPF0066_cons_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="PTHR12818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18389">
        <property type="entry name" value="TrmO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01318">
        <property type="entry name" value="TSAA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="235" mass="26422" checksum="408E8C40DEC50AD8" modified="2005-12-06" version="1">MSSFQFEQIGVIRSPYKEKFAVPRQPGLVKSANGELHLIAPYNQADAVRGLEAFSHLWILFVFHQTMEGGWRPTVRPPRLGGNARMGVFATRSTFRPNPIGMSLVELKEVVCHKDSVILKLGSLDLVDGTPVVDIKPYLPFAESLPDACASYAQSAPAAEMTVSFTAEVEKQLLTLEKRYPQLTLFIREVLAQDPRPAYRKGEETGKTYAVWLHDFNVRWRITDAGFEVFALEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JV1</accession>
    <name>Q32JV1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yadS</name>
        <name evidence="9" type="ordered locus">SDY_0173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000964236.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401895.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JV1"/>
    <dbReference type="STRING" id="300267.SDY_0173"/>
    <dbReference type="EnsemblBacteria" id="ABB60406">
        <property type="protein sequence ID" value="ABB60406"/>
        <property type="gene ID" value="SDY_0173"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0173"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.199"/>
    <dbReference type="HOGENOM" id="CLU_064906_2_1_6"/>
    <dbReference type="OMA" id="RAPRAWN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="92"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB60406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="207" mass="22232" checksum="1A4E7A1D58AEED66" modified="2005-12-06" version="1">MLVYWLDIVGTAVFAISGVLLAGKLRMDPFGVLVLGVVTAVGGGTIRDMELDHGPVFWVKDPTDLVVAMVTSMLTIVLVRQPRRLPKWMLPVLDAVGLAVFVGIGVNKAFNAEAGPLIAVCMGVITGVGCGIIRDVLAREIPMILRTEIYATACIIGGIVHATAYYTFSVPLETASMMGMVVTLLIRLAAIRWHLKLPTFALDENGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JX5</accession>
    <name>Q32JX5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JX5"/>
    <dbReference type="STRING" id="300267.SDY_0148"/>
    <dbReference type="EnsemblBacteria" id="ABB60382">
        <property type="protein sequence ID" value="ABB60382"/>
        <property type="gene ID" value="SDY_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0148"/>
    <dbReference type="HOGENOM" id="CLU_1853866_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021728">
        <property type="entry name" value="DUF3300"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40269">
        <property type="entry name" value="PTHR40269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11737">
        <property type="entry name" value="DUF3300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="138" mass="15382" checksum="2278724075E29243" modified="2005-12-06" version="1">MLMASTYPANVAQAVQWSHDNPLKQGDAAIQAVPDQPWNASVKSLVAFPQLMALMGENPQWVQNLGDAFLAQPQDVMDSVQRLRQLAQQTGSLKSSTEQKVITTTKKTVPVTQTVTAPVIRFNCQPRHYRACNNRHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K38</accession>
    <name>Q32K38_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yabP</name>
        <name evidence="1" type="ordered locus">SDY_0081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000868875.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401808.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K38"/>
    <dbReference type="EnsemblBacteria" id="ABB60319">
        <property type="protein sequence ID" value="ABB60319"/>
        <property type="gene ID" value="SDY_0081"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0081"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.91"/>
    <dbReference type="HOGENOM" id="CLU_091636_0_0_6"/>
    <dbReference type="OMA" id="CAKNPDE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="238" mass="27249" checksum="46924ADE7A8CBB1C" modified="2005-12-06" version="1">MKVSVLGMPATLLNMSNNDIYKMVSRDKMDMKMNIFQRLWETLRHLFWSDKQTEAYKLLFNFVNKKAGNINASKYFTGAVNENEKEKFINSLELFNELKTCAKNPDEMVAKGNMRWVAETYGDIELSVTFFIENNEICTQTLQLHKGPGNLGVDLGEAYLPGVDMRNCYLGKKTMKGKDEILYEQPGWNANLDGAIHLYDEVIIIYKITPKKIDTEEIATKQSTAEEIIAPQLLNDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q32K53</accession>
    <name>Q32K53_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fixX</name>
        <name evidence="4" type="ordered locus">SDY_0066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Could be a 3Fe-4S cluster-containing protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial-type ferredoxin family. FixX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000203741.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_401793.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32K53"/>
    <dbReference type="SMR" id="Q32K53"/>
    <dbReference type="STRING" id="300267.SDY_0066"/>
    <dbReference type="EnsemblBacteria" id="ABB60304">
        <property type="protein sequence ID" value="ABB60304"/>
        <property type="gene ID" value="SDY_0066"/>
    </dbReference>
    <dbReference type="GeneID" id="67416119"/>
    <dbReference type="KEGG" id="sdy:SDY_0066"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.75"/>
    <dbReference type="HOGENOM" id="CLU_163428_1_0_6"/>
    <dbReference type="OMA" id="LECGSCR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012206">
        <property type="entry name" value="Fd_FixX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43082">
        <property type="entry name" value="PTHR43082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036548">
        <property type="entry name" value="Fdx_FixX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="95" mass="10479" checksum="999A9C8D5B694BE3" modified="2005-12-06" version="1">MTSPVNVDVKLGVNKFNVDEEHPHIVVKADADKQALELLVKACPAGLYKKQDDGSVRFDYAGCLECGTCRILGLGSALEQWEYPRGTFGVEFRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q326N9</accession>
    <name>Q326N9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406207.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326N9"/>
    <dbReference type="EnsemblBacteria" id="ABB64719">
        <property type="protein sequence ID" value="ABB64719"/>
        <property type="gene ID" value="SDY_P206"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P206"/>
    <dbReference type="HOGENOM" id="CLU_2828861_0_0_6"/>
    <dbReference type="OMA" id="RFMRLLW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="66" mass="7712" checksum="02495A5876E76E86" modified="2005-12-06" version="1">MARTRSGRETSRTITAHRLRGNTGRRVIEGDLSSYVDTVHHRLLMKALCRRISDARFMRLLWKTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q326S4</accession>
    <name>Q326S4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IpgD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ipgD</name>
        <name evidence="5" type="ordered locus">SDY_P171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Sd197</strain>
            <plasmid evidence="6">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase IpgD/SopB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000548332.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406172.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326S4"/>
    <dbReference type="EnsemblBacteria" id="ABB64684">
        <property type="protein sequence ID" value="ABB64684"/>
        <property type="gene ID" value="SDY_P171"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P171"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5729"/>
    <dbReference type="HOGENOM" id="CLU_025781_1_0_6"/>
    <dbReference type="OMA" id="CWNCKSG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008108">
        <property type="entry name" value="IpgD/SopB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05925">
        <property type="entry name" value="IpgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01734">
        <property type="entry name" value="TYPE3OMBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB64684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="538" mass="59906" checksum="B9EBD7CA9A387341" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Y0</accession>
    <name>Q326Y0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406116.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Y0"/>
    <dbReference type="EnsemblBacteria" id="ABB64628">
        <property type="protein sequence ID" value="ABB64628"/>
        <property type="gene ID" value="SDY_P115"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P115"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5670"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27534" checksum="C509ABD12576F32A" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRQRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISSAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q326Z9</accession>
    <name>Q326Z9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Post-segregation antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ccdA</name>
        <name evidence="2" type="ordered locus">SDY_P096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000813626.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406097.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q326Z9"/>
    <dbReference type="EnsemblBacteria" id="ABB64609">
        <property type="protein sequence ID" value="ABB64609"/>
        <property type="gene ID" value="SDY_P096"/>
    </dbReference>
    <dbReference type="GeneID" id="58463936"/>
    <dbReference type="KEGG" id="sdy:SDY_P096"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5647"/>
    <dbReference type="HOGENOM" id="CLU_157097_1_0_6"/>
    <dbReference type="OMA" id="HHNNIYL"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009956">
        <property type="entry name" value="Post-segregation_anti-tox_CcdA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07362">
        <property type="entry name" value="CcdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="72" mass="8333" checksum="9265B6F1FD64C31D" modified="2005-12-06" version="1">MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q327B7</accession>
    <name>Q327B7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_P078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Sd197</strain>
            <plasmid evidence="4">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406079.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327B7"/>
    <dbReference type="EnsemblBacteria" id="ABB64591">
        <property type="protein sequence ID" value="ABB64591"/>
        <property type="gene ID" value="SDY_P078"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P078"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5626"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14900" checksum="F065643F361CBFD7" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPCDVVIWMTDGWPLYESRLKGKLHIISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q327C2</accession>
    <name>Q327C2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_P073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Sd197</strain>
            <plasmid evidence="3">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406074.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327C2"/>
    <dbReference type="EnsemblBacteria" id="ABB64586">
        <property type="protein sequence ID" value="ABB64586"/>
        <property type="gene ID" value="SDY_P073"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P073"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5622"/>
    <dbReference type="HOGENOM" id="CLU_2002362_0_0_6"/>
    <dbReference type="OMA" id="MTMATIN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="124" mass="14010" checksum="242852841B3ED501" modified="2005-12-06" version="1">MATINARIDDDIKNQADEVLKLMNISQTQAIAAFYQYITEQKKLPFVITSIVKTPHDLLRESTDMLAEALAVISNLQVWTEQQDGIGKAKLMEYYRRLDALYCCAKEKIGLLSDNRDAELGCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q327I0</accession>
    <name>Q327I0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000868555.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406016.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327I0"/>
    <dbReference type="EnsemblBacteria" id="ABB64528">
        <property type="protein sequence ID" value="ABB64528"/>
        <property type="gene ID" value="SDY_P015"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P015"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5547"/>
    <dbReference type="HOGENOM" id="CLU_1414317_0_0_6"/>
    <dbReference type="OMA" id="SMTYYHA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="192" mass="21873" checksum="CBC478B68AEE9B25" modified="2005-12-06" version="1">MKVSFKPLGYIFHDIYNKKHTIDEFNDVVRKAVLSGKINELNACHKVAIFLAEKDNEITKKDKAKIIDTLTENYSIEFQQLMNISERTLNSSLYITPGESGFVSFVNREGKICHTAYVKSSDNSMAYYHANGSSIDKYITDMCGLICMRHIDSTGIIFYMLDEKVLSAIAEFMNEKGWRAAFCSAKNLYKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q327J2</accession>
    <name>Q327J2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_P001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pSD1_197</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Sd197</strain>
            <plasmid evidence="2">Plasmid pSD1_197</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000035">
        <property type="protein sequence ID" value="ABB64515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_406004.1">
        <property type="nucleotide sequence ID" value="NC_007607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327J2"/>
    <dbReference type="EnsemblBacteria" id="ABB64515">
        <property type="protein sequence ID" value="ABB64515"/>
        <property type="gene ID" value="SDY_P001"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_P001"/>
    <dbReference type="HOGENOM" id="CLU_1703043_0_0_6"/>
    <dbReference type="OMA" id="DFQRGHG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Plasmid pSD1_197"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="154" mass="17062" checksum="3DE8953BCC552FF7" modified="2005-12-06" version="1">MNHYPSVTSLETPEARCRSGVPPLPACRQRESIYGLIELFIQIVHRLSVRSERRLVKTLLADFQRGHGKTALLFRIAEAALNNPDGLVKEVVYHLHIVEPDRSGKRSSSYLAQLRDVSARGDAVKNGRTLPEQDSGLPALVSDPGLPRMISTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q327N8</accession>
    <name>Q327N8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327N8"/>
    <dbReference type="STRING" id="300267.SDY_4610"/>
    <dbReference type="EnsemblBacteria" id="ABB64467">
        <property type="protein sequence ID" value="ABB64467"/>
        <property type="gene ID" value="SDY_4610"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4610"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="RIMREDN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27539" checksum="10EDA019EF9B38D0" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNPNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYTCEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q327S6</accession>
    <name>Q327S6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-binding component of dipeptide transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dppF</name>
        <name evidence="6" type="ordered locus">SDY_4563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000107011.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405920.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327S6"/>
    <dbReference type="STRING" id="300267.SDY_4563"/>
    <dbReference type="EnsemblBacteria" id="ABB64429">
        <property type="protein sequence ID" value="ABB64429"/>
        <property type="gene ID" value="SDY_4563"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4563"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5401"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_6"/>
    <dbReference type="OMA" id="GRYPHMF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="13"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB64429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="334" mass="37590" checksum="4E5FB9E549511CB5" modified="2005-12-06" version="1">MSTQEATLQQPLLQAIDLKKHYPVKKGMFAPERLVKALDGVSFNLERGKTLAVVGESGCGKSTLCRLLTMIETPTGGELYYQGQDLLKHDPQAQKLRRQKIQIVFQNPYGSLNPRKKVGQILEEPLLINTSLSKEQRREKALSMMAKVGLKTEHYDRYPHMFSGGQRQRIAIARGLMLDPDVVIADEPVSALDVSVRAQVLNLMMDLQQELGLSYVFISHDLSVVEHIADEVMVMYLGRCVEKGTKDQIFNNPRHPYTQALLSATPRLNPDDRRERIKLTGELPSPLNPPPGCAFNARCRRRFGPCTQLQPQLKDYGGQLVACFAVDQDENPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q327Z3</accession>
    <name>Q327Z3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405853.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q327Z3"/>
    <dbReference type="STRING" id="300267.SDY_4486"/>
    <dbReference type="EnsemblBacteria" id="ABB64362">
        <property type="protein sequence ID" value="ABB64362"/>
        <property type="gene ID" value="SDY_4486"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4486"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5296"/>
    <dbReference type="HOGENOM" id="CLU_2810063_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="67" mass="7781" checksum="F125F51BAEA4E383" modified="2005-12-06" version="1">MDMASIDDLQEEKKKKGAKGVTARWQRRMKLTPCVVMTCYMLPGNMQISEHKVRCTGNSGHYHLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q328A7</accession>
    <name>Q328A7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_4472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328A7"/>
    <dbReference type="STRING" id="300267.SDY_4472"/>
    <dbReference type="EnsemblBacteria" id="ABB64348">
        <property type="protein sequence ID" value="ABB64348"/>
        <property type="gene ID" value="SDY_4472"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4472"/>
    <dbReference type="HOGENOM" id="CLU_101320_7_0_6"/>
    <dbReference type="OMA" id="RGYCVDT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="105" mass="12250" checksum="6047CE1C2647BAE0" modified="2005-12-06" version="1">MYGFWKLNAVQIISIMLVEIPPKMSVSGFMGYLKGKSSLMLYEQFGDLKFKYRNRAFWCSRGYYVDTVDKNTAKIQDYIKHQLEEDKMGEQLSIPYPGSPFTGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q328C8</accession>
    <name>Q328C8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YjeG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjeG</name>
        <name evidence="3" type="ordered locus">SDY_4445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001267440.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405818.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328C8"/>
    <dbReference type="STRING" id="300267.SDY_4445"/>
    <dbReference type="EnsemblBacteria" id="ABB64327">
        <property type="protein sequence ID" value="ABB64327"/>
        <property type="gene ID" value="SDY_4445"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4445"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5243"/>
    <dbReference type="HOGENOM" id="CLU_085083_0_0_6"/>
    <dbReference type="OMA" id="WLRGMSK"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="158" mass="17706" checksum="7B3922BFE14616BB" modified="2005-12-06" version="1">MRWLPFIAIFLYVYIEISIFIQVAHVLGVLLTLVLVIFTSVIGMSLVRNQGFKNFVLMQQKMAAGENPAAEMIKSVSLIIAGLLLLLPGFFTDFLGLLLLLPPLQKHLTVKLMPHLRFSRMPGGGFSAGTGGGNTFDGEYQRKDDERDRLDHKDDRQD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q328D1</accession>
    <name>CUTA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Divalent-cation tolerance protein CutA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cutA</name>
        <name type="ordered locus">SDY_4442</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in resistance toward heavy metals.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000883400.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405815.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328D1"/>
    <dbReference type="SMR" id="Q328D1"/>
    <dbReference type="STRING" id="300267.SDY_4442"/>
    <dbReference type="EnsemblBacteria" id="ABB64324">
        <property type="protein sequence ID" value="ABB64324"/>
        <property type="gene ID" value="SDY_4442"/>
    </dbReference>
    <dbReference type="GeneID" id="66671951"/>
    <dbReference type="KEGG" id="sdy:SDY_4442"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5240"/>
    <dbReference type="HOGENOM" id="CLU_098807_3_0_6"/>
    <dbReference type="OMA" id="VYTTFPD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01160">
        <property type="entry name" value="CutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023700">
        <property type="entry name" value="CutA_Enterobact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0186">Copper</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000280486" description="Divalent-cation tolerance protein CutA">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01160"/>
        </source>
    </evidence>
    <sequence length="112" mass="12331" checksum="802145EF012DDB69" modified="2005-12-06" version="1">MLDEKSSNTASVVVLCTAPDEATAQDLAAKVLAEKLAACATLIPGATSLYYWEGKLEQEYEVQMILKTTVSHQQALLECLKSHHPYQTPELLVLPVTHGDTDYLSWLNASLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q328H3</accession>
    <name>FRDD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fumarate reductase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Fumarate reductase 13 kDa hydrophobic protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Quinol-fumarate reductase subunit D</fullName>
            <shortName evidence="1">QFR subunit D</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frdD</name>
        <name type="ordered locus">SDY_4395</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FrdD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000609663.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405773.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328H3"/>
    <dbReference type="SMR" id="Q328H3"/>
    <dbReference type="STRING" id="300267.SDY_4395"/>
    <dbReference type="EnsemblBacteria" id="ABB64282">
        <property type="protein sequence ID" value="ABB64282"/>
        <property type="gene ID" value="SDY_4395"/>
    </dbReference>
    <dbReference type="GeneID" id="58391487"/>
    <dbReference type="KEGG" id="sdy:SDY_4395"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5191"/>
    <dbReference type="HOGENOM" id="CLU_168367_0_0_6"/>
    <dbReference type="OMA" id="ACYAFAG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045284">
        <property type="term" value="C:plasma membrane fumarate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00547">
        <property type="entry name" value="QFR_TypeD_subunitD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00709">
        <property type="entry name" value="Fumarate_red_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003418">
        <property type="entry name" value="Fumarate_red_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02313">
        <property type="entry name" value="Fumarate_red_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000179">
        <property type="entry name" value="FrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000045560" description="Fumarate reductase subunit D">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00709"/>
        </source>
    </evidence>
    <sequence length="119" mass="13107" checksum="E9D119342B1D5357" modified="2005-12-06" version="1">MINPNPKRSDEPVFWGLFGAGGMWSAIIAPVMILLVGILLPLGLFPGDALSYERVLAFAQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTLIGVVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q328I6</accession>
    <name>Q328I6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytfH</name>
        <name evidence="2" type="ordered locus">SDY_4381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405760.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328I6"/>
    <dbReference type="STRING" id="300267.SDY_4381"/>
    <dbReference type="EnsemblBacteria" id="ABB64268">
        <property type="protein sequence ID" value="ABB64268"/>
        <property type="gene ID" value="SDY_4381"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4381"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5174"/>
    <dbReference type="HOGENOM" id="CLU_111585_2_0_6"/>
    <dbReference type="OMA" id="EKWVLHI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="50"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB64268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="156" mass="17564" checksum="F54B6F487348F551" modified="2005-12-06" version="1">MGSLHRFVLCLNTLTPKLTFSNYVQKGKYEMSQVSLSQQLKEGNLFAEQCPSREVLKHVTSRWGVLILVALREGTHRFSDLRRKMGGVSEKMLAQSLQALEQDGFLNRIAYPVVPPHVEYSLTPLGEQVSEKVAALADWIELNLPEVLAVRDERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q328K8</accession>
    <name>Q328K8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1471 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yjfO</name>
        <name evidence="4" type="ordered locus">SDY_4358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328K8"/>
    <dbReference type="STRING" id="300267.SDY_4358"/>
    <dbReference type="EnsemblBacteria" id="ABB64247">
        <property type="protein sequence ID" value="ABB64247"/>
        <property type="gene ID" value="SDY_4358"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4358"/>
    <dbReference type="HOGENOM" id="CLU_144052_1_0_6"/>
    <dbReference type="OMA" id="PGQWYSQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036275">
        <property type="entry name" value="YdgH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010854">
        <property type="entry name" value="YdgH/BhsA/McbA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07338">
        <property type="entry name" value="DUF1471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159871">
        <property type="entry name" value="SSF159871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1471" evidence="3">
        <location>
            <begin position="86"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="142" mass="16062" checksum="341803FC40341A31" modified="2005-12-06" version="1">MWVTLSSRFHSKIAYQVTIREHSPKVKLIRHYTMVSRKRNSVIYRFASLLLVLMLSACSALQGTPQPAPPVTDHPQEIRRDQTQGLQRIGSVSTMVRGSPDDALAEIRAKAVAAKADYYVVVMVDETIVTGQWYSQAILYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q328L2</accession>
    <name>Q328L2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-methyl-adenine DNA glycosylase I, constitutive</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tag</name>
        <name evidence="1" type="ordered locus">SDY_4353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000438949.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405734.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328L2"/>
    <dbReference type="STRING" id="300267.SDY_4353"/>
    <dbReference type="EnsemblBacteria" id="ABB64243">
        <property type="protein sequence ID" value="ABB64243"/>
        <property type="gene ID" value="SDY_4353"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4353"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5138"/>
    <dbReference type="HOGENOM" id="CLU_083758_1_0_6"/>
    <dbReference type="OMA" id="YVAYHDT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004597">
        <property type="entry name" value="Tag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00624">
        <property type="entry name" value="tag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="187" mass="21112" checksum="C15DFD4E2CC8D176" modified="2005-12-06" version="1">MERCGWVSQDPLYIAYHDNEWGVPETDSKKLFEMICLEGQQAGLSWITVLKKRENYRACFHQFDPVKVAAMQEEDVERLVQDAGIIRHRGKIQAIIGNARAYLQMEQNGEPFADFVWSFVNHQPQVTQATTLSEIPTSTPASDALSKALKKRGFKFVGTTICYSFMQTCGLVNDHVVGCCCYPGNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q328M5</accession>
    <name>Q328M5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_4320</name>
        <name evidence="4" type="ordered locus">SDY_4339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405705.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405721.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64214">
        <property type="protein sequence ID" value="ABB64214"/>
        <property type="gene ID" value="SDY_4320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB64230">
        <property type="protein sequence ID" value="ABB64230"/>
        <property type="gene ID" value="SDY_4339"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4320"/>
    <dbReference type="KEGG" id="sdy:SDY_4339"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5099"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14944" checksum="F065606CBAAE3736" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHLISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q328P3</accession>
    <name>Q328P3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative L-sorbose 1-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SDY_4317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000858547.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405703.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328P3"/>
    <dbReference type="STRING" id="300267.SDY_4317"/>
    <dbReference type="EnsemblBacteria" id="ABB64212">
        <property type="protein sequence ID" value="ABB64212"/>
        <property type="gene ID" value="SDY_4317"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4317"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5095"/>
    <dbReference type="HOGENOM" id="CLU_054732_0_0_6"/>
    <dbReference type="OMA" id="EVMAQDC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="3">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="2">
        <location>
            <begin position="187"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB64212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="409" mass="44759" checksum="33DDF5A7F60DB1D4" modified="2005-12-06" version="1">MKTTALRLYGKRDLRLETFDLPEMQEDEILATVVTDSLCLSSWKEANLGENHKKVPDDVATNPIIIGHEFCGDILAVGKKWQHKFQPGQRYVIQANLQLPDRPDCPGYSFPWVGGEATHVVIPNEVMEQDCLLAYDGETYFEGSLVEPLSCVIGAFNANYHLQEGSYNHTMGIRPQGRMLILGGTGPMGLLAIDYALHGPVNPSLLVITDTDNDKLSYARKHYPSEPQTLIHYLNATDAAFDTLMALSGGHGFDDIFVFVPNEGLVTLASSLLATDGCLNFFAGPQDKHFSAPINFYDVHYAFTHYVGTSGGNTDDMRAAVKLIEEKKVQAAKVVTHILGLNAAGETTLELPAVGGGKKLVYTGKYLPLTSLTQIQDQALAAILARHQGIWSGEAEQYLLTHAEAISHD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q328S1</accession>
    <name>AMPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="1">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Leucine aminopeptidase</fullName>
            <shortName evidence="1">LAP</shortName>
            <ecNumber evidence="1">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pepA</name>
        <name type="ordered locus">SDY_4284</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="1"/>
    <dbReference type="EC" id="3.4.11.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000397151.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405675.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328S1"/>
    <dbReference type="SMR" id="Q328S1"/>
    <dbReference type="STRING" id="300267.SDY_4284"/>
    <dbReference type="MEROPS" id="M17.003"/>
    <dbReference type="EnsemblBacteria" id="ABB64184">
        <property type="protein sequence ID" value="ABB64184"/>
        <property type="gene ID" value="SDY_4284"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4284"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.5050"/>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_6"/>
    <dbReference type="OMA" id="MKNTGPR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000019981" description="Probable cytosol aminopeptidase">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <sequence length="503" mass="54866" checksum="BF94CC87F859C2C0" modified="2005-12-06" version="1">MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSFDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADSYSKNVITRVIGEQQMKELGMHSYLAVGQGSQNESLMSVIEYKGNASEDARPIVLVGKGLTFDSGGISIKPSEGMDEMKYDMCGAAAVYGVMRMVAELQLPVNVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMANHNPLAHELIAASEQSGDRAWRLPLGDEYQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLAQFLLNRAGFNGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q328X9</accession>
    <name>Q328X9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_4224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q328X9"/>
    <dbReference type="EnsemblBacteria" id="ABB64126">
        <property type="protein sequence ID" value="ABB64126"/>
        <property type="gene ID" value="SDY_4224"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4224"/>
    <dbReference type="HOGENOM" id="CLU_1785592_0_0_6"/>
    <dbReference type="OMA" id="PMSHNLE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB64126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="145" mass="16816" checksum="09099F32E42672EC" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITPMSHNLEHQKVHTRMVKEVLKAVARANNHPYQSVFTDFIAGHPSCTVCFWETFHKMSPDSPYEYVTFCHTCRRFDLYETEAEMKADDPKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q329A4</accession>
    <name>Q329A4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS1 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">insA</name>
        <name evidence="8" type="ordered locus">SDY_4196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IS1 elements InsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405592.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329A4"/>
    <dbReference type="STRING" id="300267.SDY_4196"/>
    <dbReference type="EnsemblBacteria" id="ABB64101">
        <property type="protein sequence ID" value="ABB64101"/>
        <property type="gene ID" value="SDY_4196"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4196"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4935"/>
    <dbReference type="HOGENOM" id="CLU_076276_6_3_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024431">
        <property type="entry name" value="InsA_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12759">
        <property type="entry name" value="HTH_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Zn_Tnp_IS1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_IS1" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB64101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="91" mass="9899" checksum="E532EE8966B137F4" modified="2005-12-06" version="1">MASVSISCPSCSATDGVVRNGESTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVSLNTILRHLKNSGRSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q329B3</accession>
    <name>YIDD_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidD</name>
        <name type="ordered locus">SDY_4187</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001307474.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405583.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329B3"/>
    <dbReference type="STRING" id="300267.SDY_4187"/>
    <dbReference type="EnsemblBacteria" id="ABB64092">
        <property type="protein sequence ID" value="ABB64092"/>
        <property type="gene ID" value="SDY_4187"/>
    </dbReference>
    <dbReference type="GeneID" id="64726507"/>
    <dbReference type="GeneID" id="67464395"/>
    <dbReference type="KEGG" id="sdy:SDY_4187"/>
    <dbReference type="HOGENOM" id="CLU_144811_5_2_6"/>
    <dbReference type="OMA" id="QPTCSHY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000253167" description="Putative membrane protein insertion efficiency factor">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <sequence length="85" mass="9381" checksum="DCD2A8E612D12348" modified="2005-12-06" version="1">MAPPLSPGSRVLIALIRVYQRLISPLLGPHCRFTPTCSSYGIEALRRFGVIKGSWLTVKRVLKCHPLHPGGDDPVPPGPFDTREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q329B9</accession>
    <name>Q329B9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">DNA gyrase subunit B</fullName>
            <ecNumber evidence="4 12">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">gyrB</name>
        <name evidence="14" type="ordered locus">SDY_4181</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4 12"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000072072.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405577.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329B9"/>
    <dbReference type="SMR" id="Q329B9"/>
    <dbReference type="STRING" id="300267.SDY_4181"/>
    <dbReference type="EnsemblBacteria" id="ABB64086">
        <property type="protein sequence ID" value="ABB64086"/>
        <property type="gene ID" value="SDY_4181"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4181"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4919"/>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_6"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041423">
        <property type="entry name" value="GyrB_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18053">
        <property type="entry name" value="GyrB_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="13">
        <location>
            <begin position="418"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB64086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="804" mass="89980" checksum="D82DC03AF2560786" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q329C3</accession>
    <name>CBRA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Protein CbrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cbrA</name>
        <name type="ordered locus">SDY_4176</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbrA family.</text>
    </comment>
    <comment type="sequence caution" evidence="1">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB64082" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64082.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000399738.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405573.2">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329C3"/>
    <dbReference type="SMR" id="Q329C3"/>
    <dbReference type="STRING" id="300267.SDY_4176"/>
    <dbReference type="EnsemblBacteria" id="ABB64082">
        <property type="protein sequence ID" value="ABB64082"/>
        <property type="gene ID" value="SDY_4176"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4176"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4911"/>
    <dbReference type="HOGENOM" id="CLU_024648_1_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000320286" description="Protein CbrA">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="354" mass="40090" checksum="139F9E0D01ED64DB" modified="2008-02-26" version="2">MEHFDVAIIGLGPAGSALARKLAGKMQVIALDKKHQCGTEGFSKPCGGLLAPDAQRSFIRDGLTLPVDVIANPQIFSVKTVDVAASLTRNYQRSYININRYAFDLWMKSLIPASVEVYHDNLCRKIWREDDKWHVIFRADGWEQHITARYLVGADGANSMVRRYLYPDHQIRKYVAIQQWFAEKHPVPFYSCIFDNAITDCYSWSISKDGYFIFGGAYPMKDGQTRFTTLKEKMSAFQFQFGKAVKSEKCTVLFPSRWQDFVCGKDNAFLIGEAAGFISASSLEGISYALDSAEILRSVLLKQPEKINAAYWHATCKLRLKLFGKIVKSRCLTAPALRKWIMRSGMAHIPQLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q329F9</accession>
    <name>Q329F9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Big-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_4136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intimin/invasin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB64046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405537.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329F9"/>
    <dbReference type="STRING" id="300267.SDY_4136"/>
    <dbReference type="EnsemblBacteria" id="ABB64046">
        <property type="protein sequence ID" value="ABB64046"/>
        <property type="gene ID" value="SDY_4136"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4136"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4863"/>
    <dbReference type="HOGENOM" id="CLU_1053351_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003344">
        <property type="entry name" value="Big_1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02369">
        <property type="entry name" value="Big_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00634">
        <property type="entry name" value="BID_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51127">
        <property type="entry name" value="BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big-1" evidence="2">
        <location>
            <begin position="179"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB64046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="264" mass="27730" checksum="B42070C22558AF30" modified="2005-12-06" version="1">MASLLAGSGVVEVSGTDKNETGNWSEESDGVYTTTRTAKIAGDRHYATLKLSTWSSAQQSDAYAIRESGAVLAYSSIVTDKTTYTAGGAIKVTVTLKDSYENLVGGQRDAINLAIQLPNTKTESIAWNEDQKGIYTATYTALLLGTGLKAQLQMSGWANALTSNDYSISGDAASAQIVAMQVTTGNPDVLANGSDRHTVNVRVEDQFGNVLPEQTVTFTVTKGAAVFANAGQSADIRTDAHGMAEVDLSSTVADASTVEAKVNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q329L9</accession>
    <name>YICR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0758 protein YicR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yicR</name>
        <name type="ordered locus">SDY_4068</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0758 family. YicR subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB63986" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63986.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005016687.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405477.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329L9"/>
    <dbReference type="SMR" id="Q329L9"/>
    <dbReference type="STRING" id="300267.SDY_4068"/>
    <dbReference type="EnsemblBacteria" id="ABB63986">
        <property type="protein sequence ID" value="ABB63986"/>
        <property type="gene ID" value="SDY_4068"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_4068"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4784"/>
    <dbReference type="HOGENOM" id="CLU_073529_0_2_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00018">
        <property type="entry name" value="UPF0758_YicR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022820">
        <property type="entry name" value="UPF0758_YicR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000322704" description="UPF0758 protein YicR">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="100"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="JAMM motif" evidence="2">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="222" mass="25258" checksum="270E01BCD34044B0" modified="2008-03-18" version="2">MKNNAQLLMPREKMLKFGISALTDVELLALFLRTGTRGKDVLTLAKEMLENFGSLYGLLTSEYEQFSGVHGIGVAKFAQLKGIAELARRYYNVRMREESPLLSPEMTREFLQSQLTGEEREIFMVIFLDSQHRVITHSRIFSGTLNHVEVHPREIIREAIKINASALILAHNHPSGCAEPSKADKLITERIIKSCQFMDLRVLDHIVIGRGEYVSFAERGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q329U6</accession>
    <name>Q329U6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ilv operon leader peptide</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ilvGMEDA operon attenuator peptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ilvL</name>
        <name evidence="4" type="ordered locus">SDY_3981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001311244.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405400.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329U6"/>
    <dbReference type="EnsemblBacteria" id="ABB63909">
        <property type="protein sequence ID" value="ABB63909"/>
        <property type="gene ID" value="SDY_3981"/>
    </dbReference>
    <dbReference type="GeneID" id="64728532"/>
    <dbReference type="GeneID" id="67514194"/>
    <dbReference type="KEGG" id="sdy:SDY_3981"/>
    <dbReference type="HOGENOM" id="CLU_220955_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012567">
        <property type="entry name" value="IlvGEDA_leader"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08046">
        <property type="entry name" value="IlvGEDA_leader"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="32" mass="3231" checksum="E08810359F227CCC" modified="2005-12-06" version="1">MTALLRVISLVVISVVVIIIPPCGAALGRGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q329W8</accession>
    <name>Q329W8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dTDP-fucosamine acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.210</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TDP-fucosamine acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">wecD</name>
        <name evidence="4" type="ordered locus">SDY_3958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34443"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:68492"/>
            <dbReference type="ChEBI" id="CHEBI:68493"/>
            <dbReference type="EC" id="2.3.1.210"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WecD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.210" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405378.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329W8"/>
    <dbReference type="STRING" id="300267.SDY_3958"/>
    <dbReference type="EnsemblBacteria" id="ABB63887">
        <property type="protein sequence ID" value="ABB63887"/>
        <property type="gene ID" value="SDY_3958"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3958"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4669"/>
    <dbReference type="HOGENOM" id="CLU_101319_1_0_6"/>
    <dbReference type="OMA" id="TAYWFYR"/>
    <dbReference type="UniPathway" id="UPA00566"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009246">
        <property type="term" value="P:enterobacterial common antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02027">
        <property type="entry name" value="WecD_RffC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012752">
        <property type="entry name" value="AcTrfase_WecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02382">
        <property type="entry name" value="wecD_rffC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="1">
        <location>
            <begin position="125"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB63887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="181" mass="19599" checksum="E1A8F8DD36A94AD7" modified="2005-12-06" version="1">MQAKIAASNTGELDALQQLGFSLVEGEVDLALPVNNVSDSGAVVAQETDIPALRQLASAAFAQSRFRAPWYAPDASGRFYAQWIENAVRGIFDHQCLILRSASGDIRGYVSLRELNATDVRIGLLAGRGAGAELMQTALNWAYARGKTTLRVATQMGNTAALKRYIQSGANVESTAYWLYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q329Z2</accession>
    <name>CORA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">corA</name>
        <name type="ordered locus">SDY_3929</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake (By similarity). Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homopentamer. In the absence of Mg(2+), interactions between subunits are weakened, and dimers, trimers and tetramers can be observed in vitro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The central ion permeation pathway is formed by the first transmembrane domain from each of the five subunits. Mg(2+) binding strengthens interactions between subunits and leads to the formation of a symmetrical homopentamer surrounding a closed ion permeation pathway. Co(2+) binding also induces a conformation change. Low Mg(2+) concentrations trigger both a conformation change within each subunit and a loosening of the interactions between subunits. This results in an open ion conduction pathway. In addition, this results in a less symmetrical shape of the whole complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000947159.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405354.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q329Z2"/>
    <dbReference type="SMR" id="Q329Z2"/>
    <dbReference type="STRING" id="300267.SDY_3929"/>
    <dbReference type="EnsemblBacteria" id="ABB63863">
        <property type="protein sequence ID" value="ABB63863"/>
        <property type="gene ID" value="SDY_3929"/>
    </dbReference>
    <dbReference type="GeneID" id="66672278"/>
    <dbReference type="KEGG" id="sdy:SDY_3929"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4639"/>
    <dbReference type="HOGENOM" id="CLU_007127_5_0_6"/>
    <dbReference type="OMA" id="RQNDDMR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000239104" description="Magnesium transport protein CorA">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Probable selectivity filter" evidence="2">
        <location>
            <begin position="277"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="site" description="Essential for ion permeation" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0ABI4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9WZ31"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="316" mass="36590" checksum="CC3B1B736EE36A53" modified="2005-12-06" version="1">MLSAFQLENNRLTRLEVEESQPLVNAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFEDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32A12</accession>
    <name>Q32A12_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone biosynthesis accessory factor UbiJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yigP</name>
        <name evidence="1" type="synonym">ubiJ</name>
        <name evidence="3" type="ordered locus">SDY_3909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001309097.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405334.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32A12"/>
    <dbReference type="STRING" id="300267.SDY_3909"/>
    <dbReference type="EnsemblBacteria" id="ABB63843">
        <property type="protein sequence ID" value="ABB63843"/>
        <property type="gene ID" value="SDY_3909"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3909"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4617"/>
    <dbReference type="HOGENOM" id="CLU_100130_2_0_6"/>
    <dbReference type="OMA" id="LELDWEY"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032150">
        <property type="term" value="P:ubiquinone biosynthetic process from chorismate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02215">
        <property type="entry name" value="UbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038989">
        <property type="entry name" value="UbiJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38693">
        <property type="entry name" value="PTHR38693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="SCP2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="201" mass="22123" checksum="7C6B32BA59992A34" modified="2005-12-06" version="1">MPFKPLVTAGIESLLNTFLYRSPALKTARSRLLGKVLRVEVKGFSTSLILVFSERQVDVLGEWAGDADCTVIAYASVLPKLRDRQQLAALIRSGELEVQGDIQVVQNFVALADLAEFDPAELLAPYTGDIAAEGISKAMRGGAKFLHHGIKRQQRYVAEAITEEWRMAPGPLEVAWFAEETAAVERAVDALTKRLEKLEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AC1</accession>
    <name>Q32AC1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ARAC-type regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yijO</name>
        <name evidence="3" type="ordered locus">SDY_3789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000274632.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405225.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AC1"/>
    <dbReference type="STRING" id="300267.SDY_3789"/>
    <dbReference type="EnsemblBacteria" id="ABB63734">
        <property type="protein sequence ID" value="ABB63734"/>
        <property type="gene ID" value="SDY_3789"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3789"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4478"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_2_6"/>
    <dbReference type="OMA" id="AVGFNEY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="172"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="283" mass="32120" checksum="DD391C947232FB41" modified="2005-12-06" version="1">MYHDVSYLLSRLINGPLSLRQIYFASSNGPVPDLAYQVDFPRLEIVLEGEFVDTGAGATLVPGDVLYVPAGGWNFPQWQAPATTFSVLFGKQQLGFSVVQWDGKQYQNLAKQHVARRGPRIGSFLLQTLNEMQMQPQEQQTAKLIVASLLSHCRDLLGSQIQTASRSQALFEAIRNYIDERYASALTRESVAQAFYISPNYLSHLFQKTGAIGFNEYLNHTRLEHAKTLLKGYDLKVKEVAHACGFVDSNYFCRLFRKNTERSPSEYRRQYHSQLTEKPTTPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AT4</accession>
    <name>UGPA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName>sn-glycerol-3-phosphate transport system permease protein UgpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ugpA</name>
        <name type="ordered locus">SDY_3600</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000099273.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405062.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AT4"/>
    <dbReference type="SMR" id="Q32AT4"/>
    <dbReference type="STRING" id="300267.SDY_3600"/>
    <dbReference type="EnsemblBacteria" id="ABB63571">
        <property type="protein sequence ID" value="ABB63571"/>
        <property type="gene ID" value="SDY_3600"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3600"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4275"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_6"/>
    <dbReference type="OMA" id="LWYSVQS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000292831" description="sn-glycerol-3-phosphate transport system permease protein UgpA">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="3">
        <location>
            <begin position="76"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="295" mass="33274" checksum="E3D11FAF0D21F579" modified="2005-12-06" version="1">MSSSRPVFRSRWLPYLLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGFSSQFVGLDNFVALFHDSYYIDSFWTTIKFSTFVTVSGLLVSLFFAALVEYIVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYDWNHAQNSGQAMFLVVFASVWKQISYNFLFFYAALQSIPRSLIEAAAIDGVGPIRRFFKIALPLIAPVSFFLLVVNLVYAFFDTFPVIDAATSGGPVQAITTLIYKIYREGFTGLDLASSAAQSVVLMFLVIVLTVVQFRYVESKVRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32AY7</accession>
    <name>Q32AY7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hdeD</name>
        <name evidence="2" type="ordered locus">SDY_3542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000965669.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_405009.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32AY7"/>
    <dbReference type="STRING" id="300267.SDY_3542"/>
    <dbReference type="EnsemblBacteria" id="ABB63518">
        <property type="protein sequence ID" value="ABB63518"/>
        <property type="gene ID" value="SDY_3542"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3542"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4202"/>
    <dbReference type="HOGENOM" id="CLU_091585_6_0_6"/>
    <dbReference type="OMA" id="VRGPQFG"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB63518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="190" mass="20917" checksum="B6B54D58A13F7ED5" modified="2005-12-06" version="1">MLYIDKATILKFDLEMLKKHRRAIQFIAVLLFIVGLLCISFPFVSGDILSTVVGALLICSGIALIVGLFSNRSHNFWPVLSGFLVAVAYLLIGYFFIRAPELGIFAIAAFIAGLFCVAGVIRLMSWYRQRSMKGSWLQLVIGVLDIVIAWIFLGATPMLSVTLVSTLVGIELIFSAASLFSFASLFVKQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B22</accession>
    <name>TUSC_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein TusC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA 2-thiouridine synthesizing protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tusC</name>
        <name type="ordered locus">SDY_3505</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DsrF/TusC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000820736.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404974.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B22"/>
    <dbReference type="SMR" id="Q32B22"/>
    <dbReference type="STRING" id="300267.SDY_3505"/>
    <dbReference type="EnsemblBacteria" id="ABB63483">
        <property type="protein sequence ID" value="ABB63483"/>
        <property type="gene ID" value="SDY_3505"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3505"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4159"/>
    <dbReference type="HOGENOM" id="CLU_155943_1_0_6"/>
    <dbReference type="OMA" id="LEMILIM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00389">
        <property type="entry name" value="Thiourid_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037450">
        <property type="entry name" value="Sulphur_relay_TusC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017462">
        <property type="entry name" value="Sulphur_relay_TusC/DsrF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38780">
        <property type="entry name" value="PTHR38780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03010">
        <property type="entry name" value="sulf_tusC_dsrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000234457" description="Protein TusC">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00389"/>
        </source>
    </evidence>
    <sequence length="119" mass="13087" checksum="BC3FE62E87853804" modified="2005-12-06" version="1">MKRIAFVFSTVPHGTAAGREGLDALLATSALTDELAVFFIADGVFQLLPGQKPDAVLARDYIATFKLLGLYDIEQCWVCAASLRERGLDPQTPFVVEATPLEADALRRELANYDVILRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q32B57</accession>
    <name>RL17_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplQ</name>
        <name type="ordered locus">SDY_3470</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001216368.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404939.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32B57"/>
    <dbReference type="SMR" id="Q32B57"/>
    <dbReference type="STRING" id="300267.SDY_3470"/>
    <dbReference type="EnsemblBacteria" id="ABB63448">
        <property type="protein sequence ID" value="ABB63448"/>
        <property type="gene ID" value="SDY_3470"/>
    </dbReference>
    <dbReference type="GeneID" id="64727529"/>
    <dbReference type="GeneID" id="67463958"/>
    <dbReference type="KEGG" id="sdy:SDY_3470"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.4123"/>
    <dbReference type="HOGENOM" id="CLU_074407_2_0_6"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000267946" description="50S ribosomal protein L17">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <sequence length="127" mass="14365" checksum="D96DF17C07013A11" modified="2005-12-06" version="1">MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTLPKAKELRRVVEPLITLAKTDSVANRRLAFARTRDNEIVAKLFNELGPRFASRAGGYTRILKCGFRAGDNAPMAYIELVDRSEKAEAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BS9</accession>
    <name>Q32BS9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transport periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_3217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011378868.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404717.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BS9"/>
    <dbReference type="STRING" id="300267.SDY_3217"/>
    <dbReference type="EnsemblBacteria" id="ABB63226">
        <property type="protein sequence ID" value="ABB63226"/>
        <property type="gene ID" value="SDY_3217"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3217"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3842"/>
    <dbReference type="HOGENOM" id="CLU_017028_0_3_6"/>
    <dbReference type="OMA" id="TMLDTMH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220632" evidence="1">
        <location>
            <begin position="21"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="75"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="535" mass="60822" checksum="01E4F0FFC13670F4" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q32BW5</accession>
    <name>GCSP_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="1">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gcvP</name>
        <name type="ordered locus">SDY_3178</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000195016.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404681.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32BW5"/>
    <dbReference type="SMR" id="Q32BW5"/>
    <dbReference type="STRING" id="300267.SDY_3178"/>
    <dbReference type="EnsemblBacteria" id="ABB63190">
        <property type="protein sequence ID" value="ABB63190"/>
        <property type="gene ID" value="SDY_3178"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3178"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3796"/>
    <dbReference type="HOGENOM" id="CLU_004620_1_1_6"/>
    <dbReference type="OMA" id="CVPMSEY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000045617" description="Glycine dehydrogenase (decarboxylating)">
        <location>
            <begin position="1"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <sequence length="957" mass="104303" checksum="961847624543904A" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C26</accession>
    <name>Q32C26_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Periplasmic L-asparaginase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ansB</name>
        <name evidence="12" type="ordered locus">SDY_3115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000394107.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404620.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C26"/>
    <dbReference type="SMR" id="Q32C26"/>
    <dbReference type="STRING" id="300267.SDY_3115"/>
    <dbReference type="EnsemblBacteria" id="ABB63129">
        <property type="protein sequence ID" value="ABB63129"/>
        <property type="gene ID" value="SDY_3115"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3115"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3725"/>
    <dbReference type="HOGENOM" id="CLU_019134_1_2_6"/>
    <dbReference type="OMA" id="RKNHTSR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00520">
        <property type="entry name" value="asnASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220752" evidence="9">
        <location>
            <begin position="23"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="11">
        <location>
            <begin position="235"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="3">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604550-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB63129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="348" mass="36851" checksum="A5205BD8E007DDC8" modified="2005-12-06" version="1">MEFFKKTALAALVMGFSGAALALPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDDVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKTVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q32C82</accession>
    <name>Q32C82_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Positive regulator for lys</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysR</name>
        <name evidence="3" type="ordered locus">SDY_3056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB63073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000741827.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404564.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32C82"/>
    <dbReference type="STRING" id="300267.SDY_3056"/>
    <dbReference type="EnsemblBacteria" id="ABB63073">
        <property type="protein sequence ID" value="ABB63073"/>
        <property type="gene ID" value="SDY_3056"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_3056"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3661"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_3_6"/>
    <dbReference type="OMA" id="FHAVMTT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08456">
        <property type="entry name" value="PBP2_LysR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037414">
        <property type="entry name" value="LysR_PBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB63073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="311" mass="34423" checksum="15980B00C92CF8E8" modified="2005-12-06" version="1">MAAVNLRHIEIFHAVMTAGSLTEAAHLLHTSQPTVSRELARFEKVIGLKLFERVRGRLHPTVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIACLPVFSQSFLPQLLQPFLARYPDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHTPAGTERTELLSLDEVCVLPPGHPLAVKKVLTPDDFQGENYISLSRTDSYRQLLDQLFTEHQVKRRMIVETHSAASVCAMVRAGVGVSVVNPLTALDYAASGLVVRRFSIAVPFTVSLIRPLHRPSSALVQAFSEHLQAGLPKLVTSLDAILSSATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CG7</accession>
    <name>Q32CG7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_2962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404479.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CG7"/>
    <dbReference type="EnsemblBacteria" id="ABB62988">
        <property type="protein sequence ID" value="ABB62988"/>
        <property type="gene ID" value="SDY_2962"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2962"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3554"/>
    <dbReference type="HOGENOM" id="CLU_076276_2_1_6"/>
    <dbReference type="OMA" id="XGTEVSC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="125" mass="14940" checksum="F065607D6E18DB56" modified="2005-12-06" version="1">MDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFPKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CI7</accession>
    <name>PIMT_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="1">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pcm</name>
        <name type="ordered locus">SDY_2942</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000254708.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404459.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CI7"/>
    <dbReference type="SMR" id="Q32CI7"/>
    <dbReference type="STRING" id="300267.SDY_2942"/>
    <dbReference type="EnsemblBacteria" id="ABB62968">
        <property type="protein sequence ID" value="ABB62968"/>
        <property type="gene ID" value="SDY_2942"/>
    </dbReference>
    <dbReference type="GeneID" id="66673383"/>
    <dbReference type="KEGG" id="sdy:SDY_2942"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3534"/>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_6"/>
    <dbReference type="OMA" id="TISAIHM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000004826" description="Protein-L-isoaspartate O-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <sequence length="208" mass="23258" checksum="BFA179567527A118" modified="2005-12-06" version="1">MVSRRVQALLDQLRAQGIQDEQVLNALAAVPREKFVDEAFEQKAWDNIALPIGQGQTISQPYMVARMTELLELTPQSRVLEIGTGSGYQTAILAHLVQHVCSVERIKGLQWQARRRLKNLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPPEIPTALMTQLDEGGILVLPVGEEHQYLKRVRRRGGEFIIDTVEAVRFVPLVKGELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CK9</accession>
    <name>Q32CK9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large subunit of hydrogenase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hycE</name>
        <name evidence="3" type="ordered locus">SDY_2918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001288133.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404437.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CK9"/>
    <dbReference type="STRING" id="300267.SDY_2918"/>
    <dbReference type="EnsemblBacteria" id="ABB62946">
        <property type="protein sequence ID" value="ABB62946"/>
        <property type="gene ID" value="SDY_2918"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2918"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3505"/>
    <dbReference type="HOGENOM" id="CLU_015134_3_1_6"/>
    <dbReference type="OMA" id="CDPCFTC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="296"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="465"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="569" mass="64922" checksum="155B6E2585F09DE7" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CN5</accession>
    <name>GSH1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="1">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-ECS</fullName>
            <shortName evidence="1">GCS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gshA</name>
        <name type="ordered locus">SDY_2885</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000611804.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404411.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CN5"/>
    <dbReference type="SMR" id="Q32CN5"/>
    <dbReference type="STRING" id="300267.SDY_2885"/>
    <dbReference type="EnsemblBacteria" id="ABB62920">
        <property type="protein sequence ID" value="ABB62920"/>
        <property type="gene ID" value="SDY_2885"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2885"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3469"/>
    <dbReference type="HOGENOM" id="CLU_020728_3_0_6"/>
    <dbReference type="OMA" id="RYSWLLM"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00578">
        <property type="entry name" value="Glu_cys_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007370">
        <property type="entry name" value="Glu_cys_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006334">
        <property type="entry name" value="Glut_cys_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38761">
        <property type="entry name" value="PTHR38761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04262">
        <property type="entry name" value="Glu_cys_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01434">
        <property type="entry name" value="glu_cys_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000025188" description="Glutamate--cysteine ligase">
        <location>
            <begin position="1"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00578"/>
        </source>
    </evidence>
    <sequence length="518" mass="58269" checksum="4E58C447B4D7FF16" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32CZ6</accession>
    <name>Q32CZ6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tyrA</name>
        <name evidence="6" type="ordered locus">SDY_2766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000225197.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404300.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32CZ6"/>
    <dbReference type="STRING" id="300267.SDY_2766"/>
    <dbReference type="EnsemblBacteria" id="ABB62809">
        <property type="protein sequence ID" value="ABB62809"/>
        <property type="gene ID" value="SDY_2766"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2766"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3333"/>
    <dbReference type="HOGENOM" id="CLU_036672_1_1_6"/>
    <dbReference type="OMA" id="EHDHGMT"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008244">
        <property type="entry name" value="Chor_mut/prephenate_DH_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011277">
        <property type="entry name" value="CM_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001499">
        <property type="entry name" value="Chor_mut_pdh_Tpr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01799">
        <property type="entry name" value="CM_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="5">
        <location>
            <begin position="99"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB62809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="373" mass="42059" checksum="7F6E6D7A9500E0F8" modified="2005-12-06" version="1">MVAELTALRDQIDEVDKALLNLLAKRLELVAEVGEVKSRFGLPIYVLEREASMLASRRAEAEALGVPPDLIEDVLRRVMRESYSSENDKGFKTLCPSLRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEQHDWDRAVDIVADAGMVIVSVPIHVTEQVIGKLPPLPKDCILVDLASVKNGPLQAMLAAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRKPEAYQWFLEQIQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSERNLALIKRYYKRFGEAIELLEQGDKQAFIDSFRKVEHWFGDYAQRFQSESRVLLRQANDNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DA1</accession>
    <name>Q32DA1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sensor protein</fullName>
            <ecNumber evidence="14">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">narQ</name>
        <name evidence="18" type="ordered locus">SDY_2653</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="14"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001307936.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404195.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DA1"/>
    <dbReference type="STRING" id="300267.SDY_2653"/>
    <dbReference type="EnsemblBacteria" id="ABB62704">
        <property type="protein sequence ID" value="ABB62704"/>
        <property type="gene ID" value="SDY_2653"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2653"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3202"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_10_6"/>
    <dbReference type="OMA" id="IKHSQGT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029095">
        <property type="entry name" value="NarX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042295">
        <property type="entry name" value="NarX-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016380">
        <property type="entry name" value="Sig_transdc_His_kin_NarX/NarQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13675">
        <property type="entry name" value="PilJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003167">
        <property type="entry name" value="STHK_NarX/NarQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12 14" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="17">
        <location>
            <begin position="174"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="364"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR003167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB62704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="566" mass="63670" checksum="F2FBE5A7DF286FE8" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DD0</accession>
    <name>Q32DD0_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfate transport system permease protein CysT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysU</name>
        <name evidence="13" type="ordered locus">SDY_2620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000458410.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404166.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DD0"/>
    <dbReference type="STRING" id="300267.SDY_2620"/>
    <dbReference type="EnsemblBacteria" id="ABB62675">
        <property type="protein sequence ID" value="ABB62675"/>
        <property type="gene ID" value="SDY_2620"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2620"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3157"/>
    <dbReference type="HOGENOM" id="CLU_016047_14_0_6"/>
    <dbReference type="OMA" id="VFISGNM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011865">
        <property type="entry name" value="CysT_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF10">
        <property type="entry name" value="PTHR30406:SF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02139">
        <property type="entry name" value="permease_CysT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="60"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB62675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="277" mass="30282" checksum="4392811B0CAB6282" modified="2005-12-06" version="1">MFAVSSRRVLPGFTLSLGTSLLFVCLILLLPLSALVMQLAQMSWAQYWEVITNPQVVAAYKVTLLSAFVASIFNGVFGLLMAWILTRYRFPGRTLLDALMDLPFALPTAVAGLTLASLFSVNGFYGEWLAKFDIKVTYTWLGIAVAMAFTSIPFVVRTVQSVLEELGPEYEEAAETLGATRWQSFCKVVLPELSPALVAGVALSFTRSLGEFGAVIFIAGNIAWKTEVTSLMIFVRLQEFDYPAASAIASVILAASLLLLFSINTLQSRFGRRVVGH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DE2</accession>
    <name>DNLJ_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ligA</name>
        <name type="ordered locus">SDY_2608</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide.</text>
            <dbReference type="EC" id="6.5.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000443676.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404154.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DE2"/>
    <dbReference type="SMR" id="Q32DE2"/>
    <dbReference type="STRING" id="300267.SDY_2608"/>
    <dbReference type="EnsemblBacteria" id="ABB62663">
        <property type="protein sequence ID" value="ABB62663"/>
        <property type="gene ID" value="SDY_2608"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2608"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3145"/>
    <dbReference type="HOGENOM" id="CLU_007764_2_1_6"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000313435" description="DNA ligase">
        <location>
            <begin position="1"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="593"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <sequence length="671" mass="73580" checksum="F56F113B327B59F7" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DG2</accession>
    <name>Q32DG2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SDY_2579</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000544371.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404134.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DG2"/>
    <dbReference type="STRING" id="300267.SDY_2579"/>
    <dbReference type="EnsemblBacteria" id="ABB62643">
        <property type="protein sequence ID" value="ABB62643"/>
        <property type="gene ID" value="SDY_2579"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2579"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.3109"/>
    <dbReference type="HOGENOM" id="CLU_020473_3_3_6"/>
    <dbReference type="OMA" id="RVARNEM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011620">
        <property type="entry name" value="Sig_transdc_His_kinase_LytS_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07694">
        <property type="entry name" value="5TM-5TMR_LYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="13">
        <location>
            <begin position="452"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB62643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="565" mass="62673" checksum="219A5189FB75A5F0" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q32DR4</accession>
    <name>Q32DR4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfbM</name>
        <name evidence="1" type="ordered locus">SDY_2471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000525365.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_404032.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32DR4"/>
    <dbReference type="SMR" id="Q32DR4"/>
    <dbReference type="STRING" id="300267.SDY_2471"/>
    <dbReference type="EnsemblBacteria" id="ABB62541">
        <property type="protein sequence ID" value="ABB62541"/>
        <property type="gene ID" value="SDY_2471"/>
    </dbReference>
    <dbReference type="GeneID" id="66673842"/>
    <dbReference type="KEGG" id="sdy:SDY_2471"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2982"/>
    <dbReference type="HOGENOM" id="CLU_110577_2_1_6"/>
    <dbReference type="OMA" id="NIWDYEE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015068">
        <property type="entry name" value="DUF1877"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035944">
        <property type="entry name" value="YfbM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08974">
        <property type="entry name" value="DUF1877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111069">
        <property type="entry name" value="SSF111069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="167" mass="18992" checksum="EC199EE5D657B5C3" modified="2005-12-06" version="1">MGMIGYFAEIDSEKINQLLESTEKPLMDNIHDTLSGLRRLDIDKRWDFLHFGLTGTSAFDPAKNDPLSRAVLGEHSLEDGIDGFLGLTWNQELAATIDRLESLDRSELRKQFSIKRLNEMEIYPGVTFSEELEGQLFASIMLDMEKLISAYRRMLRQGNHALTVIVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E51</accession>
    <name>SYN_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="1">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">asnS</name>
        <name type="ordered locus">SDY_2327</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000117883.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403895.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E51"/>
    <dbReference type="SMR" id="Q32E51"/>
    <dbReference type="STRING" id="300267.SDY_2327"/>
    <dbReference type="EnsemblBacteria" id="ABB62404">
        <property type="protein sequence ID" value="ABB62404"/>
        <property type="gene ID" value="SDY_2327"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2327"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2809"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_6"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000051431" description="Asparagine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <sequence length="466" mass="52540" checksum="078EACB54668642F" modified="2005-12-06" version="1">MSVVPVADVLQGRVAVDSEVTVRGWVRTRRDSKAGISFLAVYDGSCFDPVQAVINNSLPNYNEDVLRLTTGCSVIVTGKVVASPGQGQQFEIQASKVEVAGWVEDPDTYPMAAKRHSIEYLREVAHLRPRTNLIGAVARVRHTLAQALHRFFNEQGFFWVSTPLITASDTEGAGEMFRVSTLDLENLPRNDQGKVDFDKDFFGKESFLTVSGQLNGETYACALSKIYTFGPTFRAENSNTSRHLAEFWMLEPEVAFANLNDIAGLAEAMLKYVFKAVLEERADDMKFFAERVDKDAVSRLERFIEADFAQVDYTDAVTILENCGRKFENPVYWGVDLSSEHERYLAEEHFKAPVVVKNYPKDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDVRMLEMGLNKEDYWWYRDLRRYGTVPHSGFGLGFERLIAYVTGVQNVRDVIPFPRTPRNASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32E85</accession>
    <name>Q32E85_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipid A biosynthesis lauroyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.241</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Kdo(2)-lipid IV(A) lauroyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">htrB</name>
        <name evidence="8" type="synonym">lpxL</name>
        <name evidence="9" type="ordered locus">SDY_2293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-Kdo-(2-&gt;4)-alpha-Kdo-(2-&gt;6)-lipid IVA + dodecanoyl-[ACP] = dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:28442"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:60365"/>
            <dbReference type="ChEBI" id="CHEBI:61524"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="EC" id="2.3.1.241"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the LpxL/LpxM/LpxP family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.241" evidence="8"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021633.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403861.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32E85"/>
    <dbReference type="STRING" id="300267.SDY_2293"/>
    <dbReference type="EnsemblBacteria" id="ABB62370">
        <property type="protein sequence ID" value="ABB62370"/>
        <property type="gene ID" value="SDY_2293"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2293"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2769"/>
    <dbReference type="HOGENOM" id="CLU_049421_1_1_6"/>
    <dbReference type="OMA" id="WRIERWF"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00360">
        <property type="reaction ID" value="UER00485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008913">
        <property type="term" value="F:lauroyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036104">
        <property type="term" value="P:Kdo2-lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01942">
        <property type="entry name" value="Lipid_A_LpxL_LpxP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011920">
        <property type="entry name" value="Lipid_A_LpxL_LpxP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026649">
        <property type="entry name" value="MsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02207">
        <property type="entry name" value="lipid_A_htrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXXXXD motif" evidence="8">
        <location>
            <begin position="132"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB62370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="306" mass="35406" checksum="A9F5A1451116F815" modified="2005-12-06" version="1">MTNLPKFSTALLHPRYWLTWLGIGVLWLVVQLPYPVIYRLGCGLGKLALRFMKRRAKIVHRNLELCFPEMSEQERRKMVVKNFESVGMGMMETGMAWFWPDRRIARWTEVIGMEHIRDVQAQKRGILLVGIHFLTLELGARQFGMQEPGIGVYRPNDNPLIDWLQTWGRLRSNKSMLDRKDLKGMIKALKKGEVVWYAPDHDYGPRSSVFVPLFAVEQAATTTGTWMLARMSGACLVPFVPRRKPDGKGYQLIMLPPECSPPLDDAETTAAWMNKVVEKCIMMAPEQYMWLHRRFKTHPEGVPSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EH2</accession>
    <name>Q32EH2_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Suppressor of ompF assembly mutants</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">asmA</name>
        <name evidence="3" type="ordered locus">SDY_2198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001252372.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403774.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EH2"/>
    <dbReference type="STRING" id="300267.SDY_2198"/>
    <dbReference type="EnsemblBacteria" id="ABB62283">
        <property type="protein sequence ID" value="ABB62283"/>
        <property type="gene ID" value="SDY_2198"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2198"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2658"/>
    <dbReference type="HOGENOM" id="CLU_012870_3_1_6"/>
    <dbReference type="OMA" id="FPWLGLE"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007844">
        <property type="entry name" value="AsmA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05170">
        <property type="entry name" value="AsmA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsmA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA" evidence="2">
        <location>
            <begin position="225"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="617" mass="68945" checksum="EE9E5272D378505E" modified="2005-12-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EJ8</accession>
    <name>Q32EJ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_2171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EJ8"/>
    <dbReference type="STRING" id="300267.SDY_2171"/>
    <dbReference type="EnsemblBacteria" id="ABB62257">
        <property type="protein sequence ID" value="ABB62257"/>
        <property type="gene ID" value="SDY_2171"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2171"/>
    <dbReference type="HOGENOM" id="CLU_058765_1_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="152" mass="15910" checksum="26639C4857B874F9" modified="2005-12-06" version="1">MVDSVIHSAVMAACLWQLPGIRTHLVAFGTSVVDLTADVADPVELLMKVQLGGGTNIASAVEYGRQLIEQPAKSVIILVSDFYEGGSSSLLTHQVKKCVQSGIKVLGLAALDSTATPCYDRDTAQALVNVGAQIAAMTPGELASWLAENLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EL8</accession>
    <name>Q32EL8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yohH</name>
        <name evidence="1" type="ordered locus">SDY_2149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EL8"/>
    <dbReference type="STRING" id="300267.SDY_2149"/>
    <dbReference type="EnsemblBacteria" id="ABB62237">
        <property type="protein sequence ID" value="ABB62237"/>
        <property type="gene ID" value="SDY_2149"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2149"/>
    <dbReference type="HOGENOM" id="CLU_170391_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="114" mass="12827" checksum="0BC84012F766CE3D" modified="2005-12-06" version="1">MLLMYCHAKLKNISQHTVISAHLFLPDYSPMNRDSFYPAIACFPLLLMLTGCAPMHETRQALSQQTPAAQVDTALPTALKNGWPDSQWWLEYHDNQLTSLINNALQNAPDMQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EQ8</accession>
    <name>Q32EQ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yeiI</name>
        <name evidence="4" type="ordered locus">SDY_2106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001064968.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403688.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EQ8"/>
    <dbReference type="STRING" id="300267.SDY_2106"/>
    <dbReference type="EnsemblBacteria" id="ABB62197">
        <property type="protein sequence ID" value="ABB62197"/>
        <property type="gene ID" value="SDY_2106"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2106"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2536"/>
    <dbReference type="HOGENOM" id="CLU_027634_11_2_6"/>
    <dbReference type="OMA" id="NPGHINI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="58"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="362" mass="39661" checksum="04A4AE7A2855DE03" modified="2005-12-06" version="1">MNNREKEILAILRRNPLIQQNEIADMLQISRSRVAAHIMDLMRKGRIKGKGYILTEQEYCVVVGAINMDIRGMADIRYPQSASHPGTIHCSAGGVGRNIAHNLALLGRDVHLLSVIGDDFYGEMLLEETRRAGVNVSGCVRLHGQSTSTYLAIANRDDETVLAINDTHLLEQLTPQLLNGSRDLLRHAGVVLADCNLTAEALEWVFTLADEIPVFVDTISEFKAGKIKHWLAHIHTLKPTLPELEIVWGQAITSDADRNAAVNALHQQGVQQLFVYLPDESVYCSEKDGEQFLLTAPAHTTVDSFGADDGFMAGLVYSFLEGNNFRDSARFAMACAAISRASGSLNNPTLSADNALSLVPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32ER5</accession>
    <name>Q32ER5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yeiL</name>
        <name evidence="4" type="ordered locus">SDY_2099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005021998.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403681.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32ER5"/>
    <dbReference type="STRING" id="300267.SDY_2099"/>
    <dbReference type="EnsemblBacteria" id="ABB62190">
        <property type="protein sequence ID" value="ABB62190"/>
        <property type="gene ID" value="SDY_2099"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2099"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2526"/>
    <dbReference type="HOGENOM" id="CLU_075053_11_1_6"/>
    <dbReference type="OMA" id="TSNVQVM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="136"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB62190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="219" mass="25282" checksum="31259957CAB02B52" modified="2005-12-06" version="1">MSESAFKDCFLTDVSADTRLFHFLARDYIVQEGQQPSWLFYLTRGRSRLYATLANGRVSLIDFFAAPCFIGEIELIDKDHEPRAVQAIEECWCLALPMKHYRPLLLNDTLFLRKLCVSLSHKNYRNIVSLTQNQSFPLVNRLAAFILLSQEGDLYHEKHTQAAEYLGVSYRHLLYVLAQFVHDGLLIKSKKGYLIKNRKQLSGLALEMDPENKFSGMMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EW8</accession>
    <name>Q32EW8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0227 protein YcfP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">ycfP</name>
        <name evidence="2" type="ordered locus">SDY_2042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0227 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EW8"/>
    <dbReference type="STRING" id="300267.SDY_2042"/>
    <dbReference type="ESTHER" id="shifl-ycfp">
        <property type="family name" value="abh_upf00227"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB62137">
        <property type="protein sequence ID" value="ABB62137"/>
        <property type="gene ID" value="SDY_2042"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2042"/>
    <dbReference type="HOGENOM" id="CLU_128769_0_0_6"/>
    <dbReference type="OMA" id="KCVSEFR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01047">
        <property type="entry name" value="UPF0227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022987">
        <property type="entry name" value="UPF0227"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008886">
        <property type="entry name" value="UPF0227/Esterase_YqiA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35602">
        <property type="entry name" value="PTHR35602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05728">
        <property type="entry name" value="UPF0227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="199" mass="23311" checksum="6D30ED9F0EF52D7C" modified="2005-12-06" version="1">MNAGRKRKQVTNPGLCEEAMIIYLHGFDSNSPGNHEKVLQLQFIDPDVRLISYSTRHPKHDMQHLLKEVDKMLQLNVDERPLICGVGLGGYWAERIGFLCDIRQVIFNPNLFPYENMEGKIDRPEEYADIATKCVTNFREKNRDRCLVILSRNDEALNSQRTSEELHHYYEIVWDEEQTHKFKNISPHLQRIKAFKTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EY1</accession>
    <name>Q32EY1_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putrescine-binding periplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">potD</name>
        <name evidence="5" type="ordered locus">SDY_2029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for the activity of the bacterial periplasmic transport system of putrescine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the bacterial solute-binding protein PotD/PotF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000759317.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403615.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EY1"/>
    <dbReference type="SMR" id="Q32EY1"/>
    <dbReference type="STRING" id="300267.SDY_2029"/>
    <dbReference type="EnsemblBacteria" id="ABB62124">
        <property type="protein sequence ID" value="ABB62124"/>
        <property type="gene ID" value="SDY_2029"/>
    </dbReference>
    <dbReference type="GeneID" id="66670610"/>
    <dbReference type="KEGG" id="sdy:SDY_2029"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2442"/>
    <dbReference type="HOGENOM" id="CLU_026974_1_3_6"/>
    <dbReference type="OMA" id="FWMDNYA"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004221085" description="Putrescine-binding periplasmic protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Spermidine-binding" evidence="3">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR019574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR019574-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB62124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="348" mass="38867" checksum="1E6EB7A6B4EC63AB" modified="2005-12-06" version="1">MKKWSRHLLAAGALALGMSAAHADDNNTLYFYNWTEYVPPGLLEQFTKETGIKVIYSTYESNETMYAKLKTYKDGAYDLVVPSTYYVDKMRKEGMIQKIDKSKLTNFSNLDPDMLNKPFDPNNDYSIPYIWGATAIGVNGDAVDPKSVTSWADLWKPEYKGSLLLTDDAREVFQMALRKLGYSGNTTDPKEIEAAYNELKKLMPNVAAFNSDNPANPYMEGEVNLGMIWNGSAFVARQAGTPIDVVWPKEGGIFWMDSLAIPANAKNKEGALKLINFLLRPDVAKQVAETIGYPTPNLAARKLLSPEVANDKTLYPDAETIKNGEWQNDVGAASSIYEEYYQKLKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EY7</accession>
    <name>Q32EY7_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Sensor histidine protein kinase/phosphatase PhoQ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">phoQ</name>
        <name evidence="17" type="ordered locus">SDY_2023</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000735404.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403609.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EY7"/>
    <dbReference type="STRING" id="300267.SDY_2023"/>
    <dbReference type="EnsemblBacteria" id="ABB62118">
        <property type="protein sequence ID" value="ABB62118"/>
        <property type="gene ID" value="SDY_2023"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2023"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2436"/>
    <dbReference type="HOGENOM" id="CLU_000445_42_0_6"/>
    <dbReference type="OMA" id="TLVFIYD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015014">
        <property type="entry name" value="PhoQ_Sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038429">
        <property type="entry name" value="PhoQ_Sensor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08918">
        <property type="entry name" value="PhoQ_Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="15">
        <location>
            <begin position="274"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB62118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="486" mass="55316" checksum="DD92778B8EE048A8" modified="2005-12-06" version="1">MKKLLRLFFPLSLRVRFLLATAAVVLVLSLAYGMVALIGYSVSFDKTTFRLLRGESNLFYTLAKWENNKLHVELPENIDKQSPTMTLIYDENGQLLWAQRDVPWLMKMIQPDWLKSNGFHEIEADVNDTSLLLSGDHSIQQQLQDVREDDDDAEMTHSVAVNVYPATSRMPKLTIVVVDTIPVELKSSYMVWSWFIYVLSANLLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELLNPATTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVLQSTLRSLRSEKMSVSDAEPVMLEQISRISQQIGYYLHRASMRGGTLLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRPGQGVGLAVAREITEQYEGKIVAGESMLGGARMEVIFGRQHSTPKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EZ8</accession>
    <name>Q32EZ8_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysR_substrate domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_2012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403598.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EZ8"/>
    <dbReference type="STRING" id="300267.SDY_2012"/>
    <dbReference type="EnsemblBacteria" id="ABB62107">
        <property type="protein sequence ID" value="ABB62107"/>
        <property type="gene ID" value="SDY_2012"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_2012"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2425"/>
    <dbReference type="HOGENOM" id="CLU_1739282_0_0_6"/>
    <dbReference type="OMA" id="FMVEHIT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="150" mass="17018" checksum="1052DEB90E7EFBFD" modified="2005-12-06" version="1">MLACRRDHPLAKKQLVEWQELVGYKMIGVRSSSGNRLLIEQQLADKPWKLDWFYEVRHLSTSLGLVEAGLGISALPGLAMPHAPYSSIIGIPLVEPVIRRTLGIIRRKDAVLSPAAERFFALLINLWTDDKDNLWTNIVERQRHALQEIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-12" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q32EZ9</accession>
    <name>6PGL_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">6-phosphogluconolactonase</fullName>
            <shortName evidence="1">6-P-gluconolactonase</shortName>
            <ecNumber evidence="1">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgl</name>
        <name type="ordered locus">SDY_2011</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000815435.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403597.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32EZ9"/>
    <dbReference type="SMR" id="Q32EZ9"/>
    <dbReference type="STRING" id="300267.SDY_2011"/>
    <dbReference type="EnsemblBacteria" id="ABB62106">
        <property type="protein sequence ID" value="ABB62106"/>
        <property type="gene ID" value="SDY_2011"/>
    </dbReference>
    <dbReference type="GeneID" id="66670962"/>
    <dbReference type="KEGG" id="sdy:SDY_2011"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2424"/>
    <dbReference type="HOGENOM" id="CLU_038716_2_0_6"/>
    <dbReference type="OMA" id="EGNWPRD"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01605">
        <property type="entry name" value="6P_gluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022528">
        <property type="entry name" value="6-phosphogluconolactonase_YbhE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0313">Glucose metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000291470" description="6-phosphogluconolactonase">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01605"/>
        </source>
    </evidence>
    <sequence length="331" mass="36308" checksum="D731044CFCF31A8F" modified="2005-12-06" version="1">MKQTVYIASPESQQIHVWNLNHEGALTLTQVVDVPGQVQPMVVSPDKRYLYVGVRPEFRVLAYRIAPDDGALTFAAESALPGSPTHISTDHQGQFVFVGSYNAGNVSVTRLEDGLPVGVVDVVEGLDGCHSANISPDNRTLWVPALKQDRICLFTVSDDGHLVAQDPAEVTTVEGAGPRHMVFHPNEQYAYCVNELNSSVDVWELKDPHGNIECVQTLDMMPENFSDTRWAADIHITPDGRHLYACDRTASLITVFSVSEDGSVLSKEGFQPTETQPRGFNVDHSGKYLIAAGQKSHHISVYEIVGEQGLLHEKGRYAVGQGPMWVVVNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F54</accession>
    <name>Q32F54_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000882228.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403542.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F54"/>
    <dbReference type="EnsemblBacteria" id="ABB62051">
        <property type="protein sequence ID" value="ABB62051"/>
        <property type="gene ID" value="SDY_1950"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1950"/>
    <dbReference type="HOGENOM" id="CLU_2751354_0_0_6"/>
    <dbReference type="OMA" id="IPRVYFI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020099">
        <property type="entry name" value="DUF5445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17520">
        <property type="entry name" value="DUF5445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB62051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="70" mass="8274" checksum="42E3A74E0645C4AA" modified="2005-12-06" version="1">MLCFLIYITLPFIPRVYFISSEKKLTIHIVQMFHLLSQVFYNLKMFLMMDMLGVGDAININTNKNIRQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F57</accession>
    <name>Q32F57_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycjC</name>
        <name evidence="3" type="ordered locus">SDY_1945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001278727.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403539.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F57"/>
    <dbReference type="SMR" id="Q32F57"/>
    <dbReference type="STRING" id="300267.SDY_1945"/>
    <dbReference type="EnsemblBacteria" id="ABB62048">
        <property type="protein sequence ID" value="ABB62048"/>
        <property type="gene ID" value="SDY_1945"/>
    </dbReference>
    <dbReference type="GeneID" id="67417375"/>
    <dbReference type="KEGG" id="sdy:SDY_1945"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.2346"/>
    <dbReference type="HOGENOM" id="CLU_085376_1_4_6"/>
    <dbReference type="OMA" id="VELLFVH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="185" mass="20092" checksum="D7D0D3FD794A7768" modified="2005-12-06" version="1">MSDEGLAPGKRLSEIRQQQGLSQRRAAELSGLTHSAISTIEQDKVSPAISTLQKLLKVYGLSLSEFFSEPEKPDEPQVVINQDDLIEMGSQGVSMKLVHNGNPNRTLAMIFETYQPGTTTGERIKHQGEEIGTVLEGEIVLTINGQDYHLVAGQSYAINTGIPHSFSNTSAGICRIISAHTPTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q32F92</accession>
    <name>Q32F92_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_1907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32F92"/>
    <dbReference type="EnsemblBacteria" id="ABB62013">
        <property type="protein sequence ID" value="ABB62013"/>
        <property type="gene ID" value="SDY_1907"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1907"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB62013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="69" mass="8296" checksum="CD4283F1FCB9C602" modified="2005-12-06" version="1">MTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FA5</accession>
    <name>Q32FA5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS600 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FA5"/>
    <dbReference type="STRING" id="300267.SDY_1894"/>
    <dbReference type="EnsemblBacteria" id="ABB62000">
        <property type="protein sequence ID" value="ABB62000"/>
        <property type="gene ID" value="SDY_1894"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1894"/>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_6"/>
    <dbReference type="OMA" id="CISCLVS"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB62000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="237" mass="27200" checksum="3CFC296FCDE28291" modified="2005-12-06" version="1">MAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQKRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWGGGPDVCCHTGGMVYLAGIKDVYTCEIVGYAMGECMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQFGLKTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHSRLGNISPAAFREKYHQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q32FT1</accession>
    <name>Q32FT1_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_1703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32FT1"/>
    <dbReference type="EnsemblBacteria" id="ABB61824">
        <property type="protein sequence ID" value="ABB61824"/>
        <property type="gene ID" value="SDY_1703"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1703"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="71" mass="7944" checksum="48C543F2204A832C" modified="2005-12-06" version="1">MAVTAAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITINHQSHCQQNQYLHGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G31</accession>
    <name>Q32G31_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">marA</name>
        <name evidence="3" type="ordered locus">SDY_1596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G31"/>
    <dbReference type="STRING" id="300267.SDY_1596"/>
    <dbReference type="EnsemblBacteria" id="ABB61724">
        <property type="protein sequence ID" value="ABB61724"/>
        <property type="gene ID" value="SDY_1596"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1596"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_14_6"/>
    <dbReference type="OMA" id="FKKHFNT"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="129" mass="15388" checksum="28FF79315B7B2E43" modified="2005-12-06" version="1">MTMSKRNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRMTNMQGESRFLHPLNHYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q32G93</accession>
    <name>Q32G93_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydjY</name>
        <name evidence="2" type="ordered locus">SDY_1525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005022884.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403153.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32G93"/>
    <dbReference type="STRING" id="300267.SDY_1525"/>
    <dbReference type="EnsemblBacteria" id="ABB61662">
        <property type="protein sequence ID" value="ABB61662"/>
        <property type="gene ID" value="SDY_1525"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1525"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1825"/>
    <dbReference type="HOGENOM" id="CLU_098233_1_0_6"/>
    <dbReference type="OMA" id="RTMSQHY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="225" mass="24213" checksum="2E99EF61C62A1997" modified="2005-12-06" version="1">MLQHYSVSWKKGLAALCLLAVAGLSGCDQKENTAAKVEYDGLSNSQPLRVDANNHTVTMLVQINGRFLTDDTRHGIVFKDGSNGHKSLFMGYATPKAFYEALKEAGGTLGENITMDNKETTHVTGSKLDISVNWQGAAKTYSFDEVIVDSNGKKLDMRFGGNLTAAEEKKTGCLVCLDSCPVGIVSNATYTYGAVEKRGEVKFKGNASVLPADNTLATVTFKITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GA0</accession>
    <name>Q32GA0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytochrome oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_1517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GA0"/>
    <dbReference type="STRING" id="300267.SDY_1517"/>
    <dbReference type="EnsemblBacteria" id="ABB61655">
        <property type="protein sequence ID" value="ABB61655"/>
        <property type="gene ID" value="SDY_1517"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1517"/>
    <dbReference type="HOGENOM" id="CLU_1719920_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="155" mass="17473" checksum="0DEE615207B7D1DA" modified="2005-12-06" version="1">MPVLDRHLHPRIKPLLHQCVWVLDKPGITPDGLTLVGFAIGVLALPFLALGWYLAALVVILLNRLLDGLDGALARRRGLTDAGGFLDISLDFLFYALVPFGFILLHRSKMRWQAAGCCLRSLVRAAVFSPLLRWRRNIRLIIPVMRINRFIIWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GF0</accession>
    <name>Q32GF0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ynbE</name>
        <name evidence="1" type="ordered locus">SDY_1466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000706310.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403096.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GF0"/>
    <dbReference type="STRING" id="300267.SDY_1466"/>
    <dbReference type="EnsemblBacteria" id="ABB61605">
        <property type="protein sequence ID" value="ABB61605"/>
        <property type="gene ID" value="SDY_1466"/>
    </dbReference>
    <dbReference type="GeneID" id="66508597"/>
    <dbReference type="KEGG" id="sdy:SDY_1466"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1746"/>
    <dbReference type="HOGENOM" id="CLU_183514_0_0_6"/>
    <dbReference type="OMA" id="AGCTPRI"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025985">
        <property type="entry name" value="YnbE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13617">
        <property type="entry name" value="Lipoprotein_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="61" mass="6815" checksum="C1F75E92ED629069" modified="2005-12-06" version="1">MKIVIAAFASSFMLVGCTPRIEVAAPKEPITINMNVKIEHEIIIKADKDVEDLLKTRSDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GI3</accession>
    <name>Q32GI3_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">insB</name>
        <name evidence="3" type="ordered locus">SDY_1157</name>
        <name evidence="4" type="ordered locus">SDY_1429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61314">
        <property type="protein sequence ID" value="ABB61314"/>
        <property type="gene ID" value="SDY_1157"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61572">
        <property type="protein sequence ID" value="ABB61572"/>
        <property type="gene ID" value="SDY_1429"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1157"/>
    <dbReference type="KEGG" id="sdy:SDY_1429"/>
    <dbReference type="HOGENOM" id="CLU_076276_9_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005063">
        <property type="entry name" value="Transposase_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03400">
        <property type="entry name" value="DDE_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB61314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB61572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="132" mass="15217" checksum="8953CE2FCC235543" modified="2005-12-06" version="1">MTSSSARKWTNSGDTSGLNRASAGCFTRMTGSGRRLLRTYSVNALWPLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GN5</accession>
    <name>Q32GN5_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SDY_1375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000135021.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_403011.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GN5"/>
    <dbReference type="STRING" id="300267.SDY_1375"/>
    <dbReference type="EnsemblBacteria" id="ABB61520">
        <property type="protein sequence ID" value="ABB61520"/>
        <property type="gene ID" value="SDY_1375"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1375"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1632"/>
    <dbReference type="HOGENOM" id="CLU_001265_47_0_6"/>
    <dbReference type="OMA" id="PLYRWSR"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="5"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB61520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="383" mass="40932" checksum="423BB9209517A219" modified="2005-12-06" version="1">MARVSLSWALILGLLAGIGPMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCVETLPENKRGSSLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFSPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALLTVLCAWTQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGMSMFVFGGIAAPLSGFGGETLLKMSLAITVCYTLAFLVALTRIDNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GR9</accession>
    <name>Q32GR9_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yciL</name>
        <name evidence="6" type="ordered locus">SDY_1339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001291204.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402977.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GR9"/>
    <dbReference type="STRING" id="300267.SDY_1339"/>
    <dbReference type="EnsemblBacteria" id="ABB61486">
        <property type="protein sequence ID" value="ABB61486"/>
        <property type="gene ID" value="SDY_1339"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1339"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1588"/>
    <dbReference type="HOGENOM" id="CLU_024979_1_1_6"/>
    <dbReference type="OMA" id="SMEFAPF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB61486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="290" mass="32612" checksum="7B8EFD513F887D51" modified="2005-12-06" version="1">MSEKLQKVLARAGHGSRREIESIIEAGRVSIDGRIAKLGDRVEVTPGLKIRIDGHLISVRESAEQICRVLAYYKPEGELCTRNDPEGRPTVFDRLPKLRGARWIAVGRLDVNTCGLLLFTTDGELANRLMHPSREVEREYAVRVFGQVDDAKLRDLSRGVQLEDGPAAFKTIKFSGGEGINQWYNVTLTEGRNREVRRLWEAVGVQVSRLIRVRYGDIPLPKGLPRGGWTELDLAQTNYLRELVELPPETSSKVAVEKDRRRMKANQIRRAVKRHSQVSGGRRSGGRNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q32GY6</accession>
    <name>Q32GY6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">chaC</name>
        <name evidence="2" type="ordered locus">SDY_1270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glutathione = 5-oxo-L-proline + L-cysteinylglycine</text>
            <dbReference type="Rhea" id="RHEA:47724"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="4.3.2.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402910.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32GY6"/>
    <dbReference type="STRING" id="300267.SDY_1270"/>
    <dbReference type="EnsemblBacteria" id="ABB61419">
        <property type="protein sequence ID" value="ABB61419"/>
        <property type="gene ID" value="SDY_1270"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1270"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1507"/>
    <dbReference type="HOGENOM" id="CLU_070703_1_0_6"/>
    <dbReference type="OMA" id="LLWYTDF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="PTHR12192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="218" mass="24329" checksum="10B681A0C4F879B8" modified="2005-12-06" version="1">MQWRRCKVITRDFLMNADCKTAFGAIEESLLWSAEQRAASLAATLACRPDEGPVWIFGYGSLMWNPALEFTESCTGTLVGWHRAFCLRLTAGRGTAHQPGRMLALKEGGRTTGVAYRLPEETLEQELTLLWKREMITGCYLPTWCQLDLDDGRTVNAIVFIMDPRHPEYESDTRAQVIAPLIAAASGPLGTNAQYLFSLEQELIKLGMQDDGLNDLLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H29</accession>
    <name>FADR_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acid metabolism regulator protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fadR</name>
        <name type="ordered locus">SDY_1224</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Multifunctional regulator of fatty acid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000234823.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402867.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H29"/>
    <dbReference type="SMR" id="Q32H29"/>
    <dbReference type="STRING" id="300267.SDY_1224"/>
    <dbReference type="PRIDE" id="Q32H29"/>
    <dbReference type="EnsemblBacteria" id="ABB61376">
        <property type="protein sequence ID" value="ABB61376"/>
        <property type="gene ID" value="SDY_1224"/>
    </dbReference>
    <dbReference type="GeneID" id="66674993"/>
    <dbReference type="KEGG" id="sdy:SDY_1224"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1452"/>
    <dbReference type="HOGENOM" id="CLU_017584_9_4_6"/>
    <dbReference type="OMA" id="WETAGPN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019217">
        <property type="term" value="P:regulation of fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00696">
        <property type="entry name" value="HTH_FadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014178">
        <property type="entry name" value="FA-response_TF_FadR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028374">
        <property type="entry name" value="FadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43537:SF10">
        <property type="entry name" value="PTHR43537:SF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07840">
        <property type="entry name" value="FadR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02812">
        <property type="entry name" value="fadR_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000301515" description="Fatty acid metabolism regulator protein">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00696"/>
        </source>
    </evidence>
    <sequence length="239" mass="26969" checksum="1FECA0DDAD5EB830" modified="2005-12-06" version="1">MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQHPDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H58</accession>
    <name>OTSA_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trehalose-6-phosphate synthase</fullName>
            <shortName evidence="1">TPS</shortName>
            <ecNumber evidence="1">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha,alpha-trehalose-phosphate synthase [UDP-forming]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Osmoregulatory trehalose synthesis protein A</fullName>
            <shortName evidence="1">OtsA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">otsA</name>
        <name type="ordered locus">SDY_1193</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001295646.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402838.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H58"/>
    <dbReference type="SMR" id="Q32H58"/>
    <dbReference type="STRING" id="300267.SDY_1193"/>
    <dbReference type="CAZy" id="GT20">
        <property type="family name" value="Glycosyltransferase Family 20"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61347">
        <property type="protein sequence ID" value="ABB61347"/>
        <property type="gene ID" value="SDY_1193"/>
    </dbReference>
    <dbReference type="GeneID" id="58461800"/>
    <dbReference type="KEGG" id="sdy:SDY_1193"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1412"/>
    <dbReference type="HOGENOM" id="CLU_002351_7_1_6"/>
    <dbReference type="OMA" id="YYGFSNR"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000348919" description="Trehalose-6-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="366"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="site" description="Involved in alpha anomer selectivity" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="site" description="Involved in alpha anomer selectivity" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P31677"/>
        </source>
    </evidence>
    <sequence length="474" mass="53611" checksum="63FFB6F938056F95" modified="2005-12-06" version="1">MSRLVVVSNRIAPPDEHAASAGGLAVGILGALKAAGGLWFGWSGETGNEDQPLKKVKKGNITWASFNLSEQDLDEYYNQFSNAVLWPAFHYRLDLVQFQRPAWDGYLRVNALLADKLLPLLQDDDIIWIHDYHLLPFAHELRKRGVNNRIGFFLHIPFPTPEIFNALPTYDTLLEQLCDYDLLGFQTENDRLAFLDCLSNLTRVTTRSAKSHTAWGKAFRTEVYPIGIEPKEIAKQAAGPLPPKLAQLKAELKNVQNIFSVERLDYSKGLPERFLAYEALLEKYPQHHGKIRYTQIAPTSRGDVQAYQDIRHQLENEAGRINGKYGQLGWTPLYYLNQHFDRKLLMKIFRYSDVGLVTPLRDGMNLVAKEYVAAQDPANPGVLVLSQFAGAANELTSALIVNPYDRDEVAAALDRALTMSLAERISRHAEMLDVIVKNDINHWQECFISDLKQIVPRSAESQQRDKVATFPKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q32H99</accession>
    <name>Q32H99_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yebB</name>
        <name evidence="1" type="ordered locus">SDY_1149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32H99"/>
    <dbReference type="STRING" id="300267.SDY_1149"/>
    <dbReference type="EnsemblBacteria" id="ABB61306">
        <property type="protein sequence ID" value="ABB61306"/>
        <property type="gene ID" value="SDY_1149"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1149"/>
    <dbReference type="HOGENOM" id="CLU_086940_0_0_6"/>
    <dbReference type="OMA" id="DNVNINY"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024453">
        <property type="entry name" value="Peptidase_C92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05708">
        <property type="entry name" value="Peptidase_C92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB61306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="233" mass="26809" checksum="16DB903F8C7421E9" modified="2005-12-06" version="1">MKKCVIKIYIAPPEKINFLCYYVYSYLFQWNDNVNINYTAEYEIGDIVFTCIGAALFGQISAASNCWSNHVGIIIGHNGEDFLVAESRVPLSTITTLSRFIKRSSNQRYAIRRLDAGLTEQQKQRIVEQVPSRLRKLYHTGFKYESSRQFCSKFVFDIYKEALCIPVGEIETFGELLNSNPNAKLTFWKFWFLGSIPWERKTVTPASLWHHPGLVLIHAEVVETPQPELTEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HA6</accession>
    <name>Q32HA6_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipid A biosynthesis myristoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.243</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Kdo(2)-lauroyl-lipid IV(A) myristoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">msbB</name>
        <name evidence="6" type="synonym">lpxM</name>
        <name evidence="7" type="ordered locus">SDY_1142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] = alpha-Kdo-(2-&gt;4)-alpha-Kdo-(2-&gt;6)-lipid A + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:28438"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:58540"/>
            <dbReference type="ChEBI" id="CHEBI:61524"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="2.3.1.243"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.243" evidence="6"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000448373.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402790.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HA6"/>
    <dbReference type="STRING" id="300267.SDY_1142"/>
    <dbReference type="EnsemblBacteria" id="ABB61299">
        <property type="protein sequence ID" value="ABB61299"/>
        <property type="gene ID" value="SDY_1142"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1142"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1345"/>
    <dbReference type="HOGENOM" id="CLU_049421_1_0_6"/>
    <dbReference type="OMA" id="QMFATAP"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00360">
        <property type="reaction ID" value="UER00486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009276">
        <property type="term" value="C:Gram-negative-bacterium-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019107">
        <property type="term" value="F:myristoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036104">
        <property type="term" value="P:Kdo2-lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01944">
        <property type="entry name" value="Lipid_A_LpxM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011921">
        <property type="entry name" value="Lipid_A_MsbB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026649">
        <property type="entry name" value="MsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02208">
        <property type="entry name" value="lipid_A_msbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXXXXD motif" evidence="6">
        <location>
            <begin position="139"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB61299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="323" mass="37383" checksum="82D09E301127D499" modified="2005-12-06" version="1">METKKNNSEYIPEFDKSFRHPRHWGAWLGVAAMAGIALTPPKFRDPILARLGRFAGRLGKSSRRRALINLSLCFPERSEAEREAIVDEMFATAPQAMAMMAELAIRGPEKIQPRVDWQGLEIIEEMRRNNEKVIFLVPHGWAVDIPAMLMASQGQKMAAMFHNQGNPVFDYVWNTVRRRFGGRLHARNDGIKPFIQSVRQGYWGYYLPDQDHGPEHSEFVDFFATYKATLPAIGRLMKVCRARVVPLFPIYDGKTHRLTIQVRPPMDDLLEADDHTIARRMNEEVEIFVGPRPEQYTWILKLLKTRKPGEIQPYKRKNLYPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HH5</accession>
    <name>Q32HH5_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tail fiber protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_1065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402721.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HH5"/>
    <dbReference type="EnsemblBacteria" id="ABB61230">
        <property type="protein sequence ID" value="ABB61230"/>
        <property type="gene ID" value="SDY_1065"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1065"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1253"/>
    <dbReference type="HOGENOM" id="CLU_014979_3_0_6"/>
    <dbReference type="OMA" id="ILKTANH"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013609">
        <property type="entry name" value="Stf-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08400">
        <property type="entry name" value="phage_tail_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="phage_tail_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="349" mass="38020" checksum="B2A3D767A73FBD7D" modified="2005-12-06" version="1">MSVVISGALTDGAGIPMSGYHIILKSRVTPPEVVMHTVADVMTGNDGEYCFHARTGKYGVYLKQDWRNEYNVGDIAVYEDSKPGTLNDFLIAPDEGDLKPDVVKRFEEMVAQAQQSAGAAAGNARQTAQDVAAAAGYARAAEQAKNDIDAALTGILKTANHLSEIAAAGEKAQQKSRDNLGLKSAATMEAQSDIYDRTKGRLVIPGAFGFGRAFLYEDVIRFDAKNDFLVWVRNALPGEYSVAGPYGIIMPDTLFEGVLRIRWTDARPETREPRRRAKSLIFYGINGPIYHACYQLLSGFLTDWVKINITAEDIIYRIAASSVRNRWGDPDIGGLIIAAYQGKADDAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HL7</accession>
    <name>Q32HL7_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iroE</name>
        <name evidence="2" type="ordered locus">SDY_1023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000271275.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402679.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HL7"/>
    <dbReference type="STRING" id="300267.SDY_1023"/>
    <dbReference type="ESTHER" id="shidy-q67dv1">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB61188">
        <property type="protein sequence ID" value="ABB61188"/>
        <property type="gene ID" value="SDY_1023"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_1023"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1196"/>
    <dbReference type="HOGENOM" id="CLU_039834_3_2_6"/>
    <dbReference type="OMA" id="KPWVEAN"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220751" evidence="1">
        <location>
            <begin position="33"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="318" mass="35504" checksum="393EC79B0352F884" modified="2005-12-06" version="1">MYAREYRSTRPHKAIFFHLSCLTLICSAQVYAKPDMRPLGPNIADKGSVFYHFSVTSFDSVDGTRHYRVWTAVPNTTAPASGYPILYMLDGNAVMDRLDDELLKQLSEKTPPVIVAVGYQTNFPFDLNSRAYDYTPAAESRKTDLHSGRFSRKSGGSNNFRQLLETRIAPKVEQGLNIDRQRRGLWGHSYGGLFVLDSWLSSSYFRSYYSASPSLGRGYDALLSRVTAVEPLQFCAKHLAIMEGSATQGDNRETHAVGVLSKIHTTLTILKDKGVNVVFWDFPNLGHGPMFNASFRQALLDISGENANYTAGCHELSH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HQ3</accession>
    <name>RUTE_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable malonic semialdehyde reductase RutE</fullName>
            <ecNumber evidence="1">1.1.1.298</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rutE</name>
        <name type="ordered locus">SDY_0983</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May reduce toxic product malonic semialdehyde to 3-hydroxypropionic acid, which is excreted.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:26438"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16510"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.298"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="induction">
        <text evidence="1">Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family. HadB/RutE subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.298" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001001203.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402643.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HQ3"/>
    <dbReference type="SMR" id="Q32HQ3"/>
    <dbReference type="STRING" id="300267.SDY_0983"/>
    <dbReference type="EnsemblBacteria" id="ABB61152">
        <property type="protein sequence ID" value="ABB61152"/>
        <property type="gene ID" value="SDY_0983"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0983"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1143"/>
    <dbReference type="HOGENOM" id="CLU_084441_0_0_6"/>
    <dbReference type="OMA" id="THNGWLD"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035527">
        <property type="term" value="F:3-hydroxypropionate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02148">
        <property type="entry name" value="RutE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01204">
        <property type="entry name" value="Oxidoreductase_RutE_HadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023936">
        <property type="entry name" value="RutE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000066145" description="Probable malonic semialdehyde reductase RutE">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01204"/>
        </source>
    </evidence>
    <sequence length="196" mass="21638" checksum="2D866B6F6D37CCAC" modified="2005-12-06" version="1">MNEAVSPSALSTLFTDARTHNGWRETPVSDETLRELYALMKWGPTSANCSPARIVFIRTAEGKERLRPALSSGNLQKTLTAPVTAIVAWDSEFYERLPQLFPHGDARSWFTSSPQLAEETAFRNSSMQAAYLIIACRALGLDTGPMSGFDRQHVDDAFFAVSTLKSNLLINIGYGDSSKLFARLPRLSFEEACGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q32HQ8</accession>
    <name>Q32HQ8_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic glucose-1-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">agp</name>
        <name evidence="2" type="ordered locus">SDY_0978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001044363.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402638.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32HQ8"/>
    <dbReference type="STRING" id="300267.SDY_0978"/>
    <dbReference type="EnsemblBacteria" id="ABB61147">
        <property type="protein sequence ID" value="ABB61147"/>
        <property type="gene ID" value="SDY_0978"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0978"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.1137"/>
    <dbReference type="HOGENOM" id="CLU_030561_2_1_6"/>
    <dbReference type="OMA" id="IKTDQQW"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004220844" evidence="1">
        <location>
            <begin position="23"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB61147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="413" mass="45687" checksum="56067323BCB65264" modified="2005-12-06" version="1">MNKTLITATVAGIVLLASNAQAQTVPEGYQLQQVLMMSRHNLRAPLANNGSVLEQSTPNKWPEWDVPGGQLTTKGGVLEVYIGHYMREWLAEQGMVKSGECPPPDTVYAYANSLQRTVATAQFFITGAFPGCDIPVHHQEKMGTMDPTFNPVITDDSAAFSEQAVAPMEKELSKLQLTDSYQLLEKIVNYKDSPACKEKQQCSLVDGKNTFSAKYQQEPGVSGPLKVGNSLVDAFTLQYYEGFPMDQVAWGEIKSDQQWKVLSKLKNGYQDSLFTSPEVARNVAKPLVSYIDKALVTDRTSAPKITVLVGHDSNIASLLTALDFKPYQLHDQNERTPIGGKIVFQRWHDSKANRDLMKIEYVYQSAEQLRNADALTPQAPAQRVTLELSGCPIDADGFCPMDKFDSVLNEAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I54</accession>
    <name>Q32I54_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">MPT synthase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Molybdenum cofactor biosynthesis protein E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Molybdopterin-converting factor large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Molybdopterin-converting factor subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">moaE</name>
        <name evidence="11" type="ordered locus">SDY_0821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Sd197</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12160"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000852295.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402492.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I54"/>
    <dbReference type="STRING" id="300267.SDY_0821"/>
    <dbReference type="EnsemblBacteria" id="ABB61003">
        <property type="protein sequence ID" value="ABB61003"/>
        <property type="gene ID" value="SDY_0821"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0821"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.947"/>
    <dbReference type="HOGENOM" id="CLU_089568_2_1_6"/>
    <dbReference type="OMA" id="WPLQRVS"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB61003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="150" mass="17023" checksum="AD25413D2D2F9A14" modified="2005-12-06" version="1">MAETKIVVGPQPFSVGEEYPWLAERDEDGAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKALVEIVDEARNRWPLGRVTVIHRIGELWPGDEIVFVGVTSAHRSSAFEAGQFIMDYLKTRAPFWKREATPEGDRWVEARESDQQAAKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I65</accession>
    <name>Q32I65_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybhS</name>
        <name evidence="7" type="ordered locus">SDY_0810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000070130.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402481.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I65"/>
    <dbReference type="STRING" id="300267.SDY_0810"/>
    <dbReference type="EnsemblBacteria" id="ABB60992">
        <property type="protein sequence ID" value="ABB60992"/>
        <property type="gene ID" value="SDY_0810"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0810"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.934"/>
    <dbReference type="HOGENOM" id="CLU_039483_8_3_6"/>
    <dbReference type="OMA" id="STWYLVP"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="377" mass="42032" checksum="C25E422A4586EEFD" modified="2005-12-06" version="1">MSNPILSWRRVRALCVKETRQIVRDPSSWLIAVVIPLLLLFIFGYGINLDSSKLRVGILLEQRSEAALDFTHTMTGSPYIDATISDNRQELIAKMQAGKIRGLVVIPVDFAEQMERANATAPIQVITDGSEPNTANFVQGYVEGIWQIWQMQRAEDNGQTFEPLIDVQTRYWFNPAAISQHFIIPGAVTIIMTVIGAILTSLVVAREWERGTMEALLSTEITRTELLLCKLIPYYFLGMLAMLLCMLVSVFILGVPYRGSLLILFFISSLFLLSTLGMGLLISTITRNQFNAAQVALNAAFLPSIMLSGFIFQIDSMPAVIRAVTYIIPARYFVSTLQSLFLAGNIPVVLVVNVLFLIASAVMFIGLTWLKTKRQLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I67</accession>
    <name>YBHG_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0194 membrane protein YbhG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybhG</name>
        <name type="ordered locus">SDY_0808</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0194 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402479.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I67"/>
    <dbReference type="SMR" id="Q32I67"/>
    <dbReference type="STRING" id="300267.SDY_0808"/>
    <dbReference type="EnsemblBacteria" id="ABB60990">
        <property type="protein sequence ID" value="ABB60990"/>
        <property type="gene ID" value="SDY_0808"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0808"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.932"/>
    <dbReference type="HOGENOM" id="CLU_018816_6_3_6"/>
    <dbReference type="OMA" id="PYNLGER"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01304">
        <property type="entry name" value="UPF0194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022936">
        <property type="entry name" value="UPF0194_membrane_YbhG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_1000051814" description="UPF0194 membrane protein YbhG">
        <location>
            <begin position="17"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01304"/>
        </source>
    </evidence>
    <sequence length="332" mass="36421" checksum="69450E46A8F552EA" modified="2005-12-06" version="1" precursor="true">MMKKTVVIGLAVVVLAAVVAGGYWWYQSRQDNGLTLYGNVDIRTVNLSFRVGGRVESLAVDEGDAIKAGQVLGELDHKPYEIALMQAKAGVSVAQAQYDLMLAGYRDEEIAQAAAAVKQAQAAYDYAQNFYNRQQGLWKSRTISANDLENARSSRDQAQATLKSAQDKLRQYRSGNREQDIAQAKASLEQAQAQLAQAELNLQDSTLIAPSDGTLLTRAVEPGTVLNEGGTVFTVSLTRPVWVRAYVDERNLDQAQPGRKVLLYTDGRPDKPYHGQIGFVSPTAEFTPKTVETPDLRTDLVYRLRIVVTDADDALRQGMPVTVQFGDEAGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q32I68</accession>
    <name>Q32I68_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybiH</name>
        <name evidence="3" type="ordered locus">SDY_0807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402478.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32I68"/>
    <dbReference type="STRING" id="300267.SDY_0807"/>
    <dbReference type="EnsemblBacteria" id="ABB60989">
        <property type="protein sequence ID" value="ABB60989"/>
        <property type="gene ID" value="SDY_0807"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0807"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.931"/>
    <dbReference type="HOGENOM" id="CLU_069356_16_0_6"/>
    <dbReference type="OMA" id="EVLAFRM"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015292">
        <property type="entry name" value="Tscrpt_reg_YbiH_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09209">
        <property type="entry name" value="CecR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB60989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="227" mass="25437" checksum="92358A20DB90088B" modified="2005-12-06" version="1">MDCAMNNPAMTIKGEQAKKQLIAAALAQFGEYGMNATTREIAAQAGQNIAAITYYFGSKEDLYLACAQWIADFIGEQFRPHAEEAERLFAQPQPDRAAIRELILRACRNMIKLLTQDDTVNLSKFISREQLSPTAAYHLVHEQVISPLHSHLTRLIAAWTGCDANDTRMILHTHALIGEILAFRLGKETILLRTGWTAFDEEKTELINQTVTCHIDLILQGLSQRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IA0</accession>
    <name>Q32IA0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000930139.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402446.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IA0"/>
    <dbReference type="EnsemblBacteria" id="ABB60957">
        <property type="protein sequence ID" value="ABB60957"/>
        <property type="gene ID" value="SDY_0773"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0773"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.890"/>
    <dbReference type="HOGENOM" id="CLU_110174_0_0_6"/>
    <dbReference type="OMA" id="NDEIYRC"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025484">
        <property type="entry name" value="DUF4376"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14301">
        <property type="entry name" value="DUF4376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4376" evidence="1">
        <location>
            <begin position="96"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="208" mass="23692" checksum="DC3A8EB2BF78B570" modified="2005-12-06" version="1">MLMSLAQCLGFLFAHREECTVEIKKIINPRYTESGAVDCDVFFDDRDQAVPYTATADDVAPTGQQIWQELQSGKWGEIAPFTVTPEMLEAAREARRQEIEAWRTEQEAKPFTFEWNGRVWNAGPNSLGRLSPVVMLAKSVAAQTNMTWSDADNQQVQLTTQELEELATAMIQAIVERNDEIYRCQREMKEQLSLLPTLDEVRAYRPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IH4</accession>
    <name>Q32IH4_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SDY_0698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IH4"/>
    <dbReference type="EnsemblBacteria" id="ABB60883">
        <property type="protein sequence ID" value="ABB60883"/>
        <property type="gene ID" value="SDY_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0698"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB60883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="94" mass="10608" checksum="4B388A277CCFC9B0" modified="2005-12-06" version="1">MAVTAAKSVMAFRVMTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITGISKKNARLSRKTRSLLQFLTVTPLFVNYFKILCWISLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IM6</accession>
    <name>Q32IM6_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SDY_0641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IM6"/>
    <dbReference type="EnsemblBacteria" id="ABB60831">
        <property type="protein sequence ID" value="ABB60831"/>
        <property type="gene ID" value="SDY_0641"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0641"/>
    <dbReference type="HOGENOM" id="CLU_162059_0_1_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="84" mass="9571" checksum="2ECADB96ECDB5DE3" modified="2005-12-06" version="1">MAVTVAKSVMAFRVLTMAVDLCRLTTRTMNVNAGHERTSKARIIHQIQLIRGITDVRCEKQPWTETIWRQSLRGAGFRNLALEC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-11-16" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q32IX2</accession>
    <name>ENTH_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proofreading thioesterase EntH</fullName>
            <ecNumber evidence="1">3.1.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Enterobactin synthase component H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">entH</name>
        <name type="ordered locus">SDY_0528</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis; enterobactin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer. Dimer of dimers. Interacts specifically with the aryl carrier protein (ArCP) domain of EntB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000637953.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402224.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32IX2"/>
    <dbReference type="SMR" id="Q32IX2"/>
    <dbReference type="STRING" id="300267.SDY_0528"/>
    <dbReference type="EnsemblBacteria" id="ABB60735">
        <property type="protein sequence ID" value="ABB60735"/>
        <property type="gene ID" value="SDY_0528"/>
    </dbReference>
    <dbReference type="GeneID" id="67416358"/>
    <dbReference type="KEGG" id="sdy:SDY_0528"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.621"/>
    <dbReference type="HOGENOM" id="CLU_089876_13_1_6"/>
    <dbReference type="OMA" id="QHGGVYC"/>
    <dbReference type="UniPathway" id="UPA00017"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009239">
        <property type="term" value="P:enterobactin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00907">
        <property type="entry name" value="Thioesterase_EntH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026576">
        <property type="entry name" value="Thioesterase_EntH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413877" description="Proofreading thioesterase EntH">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile or proton acceptor" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00907"/>
        </source>
    </evidence>
    <sequence length="137" mass="14970" checksum="C8DF8DE63815F206" modified="2005-12-06" version="1">MIWKRHLTLDELNATSDNTMVAHLGIVYTRLGDDVLEAEMPVDTRTHQPFGLLHGGASAALAETLGSMAGFMMTRDGQCVVGTELNATHHRPVSEGKVRGVCQPLHLGRQNQSWEIVVFDEQGRRCCTCRLGTAVLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J51</accession>
    <name>YBAB_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein YbaB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybaB</name>
        <name type="ordered locus">SDY_0448</name>
    </gene>
    <organism>
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000467098.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402145.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J51"/>
    <dbReference type="SMR" id="Q32J51"/>
    <dbReference type="STRING" id="300267.SDY_0448"/>
    <dbReference type="EnsemblBacteria" id="ABB60656">
        <property type="protein sequence ID" value="ABB60656"/>
        <property type="gene ID" value="SDY_0448"/>
    </dbReference>
    <dbReference type="GeneID" id="66754946"/>
    <dbReference type="KEGG" id="sdy:SDY_0448"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.531"/>
    <dbReference type="HOGENOM" id="CLU_140930_0_0_6"/>
    <dbReference type="OMA" id="MGNMMKQ"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000003826" description="Nucleoid-associated protein YbaB">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <sequence length="109" mass="12015" checksum="5E05A853ABDCFABF" modified="2005-12-06" version="1">MFGKGGLGNLMKQAQQMQEKMQKMQEEIAQLEVTGESGAGLVKVTINGAHNCRRVEIDPSLLEDDKEMLEDLVAAAFNDAARRIEETQKEKMASVSSGMQLPPGFKMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q32J80</accession>
    <name>Q32J80_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane spanning export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SDY_0416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Sd197</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_001014331.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402116.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32J80"/>
    <dbReference type="STRING" id="300267.SDY_0416"/>
    <dbReference type="EnsemblBacteria" id="ABB60627">
        <property type="protein sequence ID" value="ABB60627"/>
        <property type="gene ID" value="SDY_0416"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0416"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.495"/>
    <dbReference type="HOGENOM" id="CLU_023976_8_0_6"/>
    <dbReference type="OMA" id="DQMRHAF"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006144">
        <property type="entry name" value="Secretion_HlyD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00543">
        <property type="entry name" value="HLYD_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB60627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="391" mass="43588" checksum="8C5396A1EEC90CEF" modified="2005-12-06" version="1">MNGQLQYNRGLTEPRLPRSALAVRVTSVMLLCFLGWAWYFQLDEVTTGSGTVEPSGREQVVQSLEGGILYHLGVKVGDIVEQGQPLAQLNRTKTESDVQEAMLRLYAALATSARLRAEVSNKPLVFPDELNKFPELIESETALYNTRRDGLNKATTGLTQGISLVNRELAMTQPLVKQGAASSVEVLRLQRQANELENKLSDVRTQYYVQAREELAKANAEVETRRSVIRGREDSLTRLNFTAPVRGIVQDIDVTTVGGVIAPGGKLMTIVPLDEKLLIEAKISPRDVAFIHPGQKSLVKITAYDYSIYGGLPGEVAVISPDTVQDEVRRDVYYYRVYIRTFSNHLENKSKQQFPIFPGMVATVDIRTGKKSVLDYLLKPFNKAQEALCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JC0</accession>
    <name>Q32JC0_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yaiV</name>
        <name evidence="1" type="ordered locus">SDY_0373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Sd197</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402076.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JC0"/>
    <dbReference type="STRING" id="300267.SDY_0373"/>
    <dbReference type="EnsemblBacteria" id="ABB60587">
        <property type="protein sequence ID" value="ABB60587"/>
        <property type="gene ID" value="SDY_0373"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0373"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.442"/>
    <dbReference type="HOGENOM" id="CLU_171116_0_0_6"/>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB60587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="113" mass="12804" checksum="910D6CE04878B1E3" modified="2005-12-06" version="1">MPVKDLTGITAKDAQMLSVVKPLQEFGKLDKCLSRYGTRFEFNNEKQVIFSSDVNNEDTFVILEDVISLRREENVLIGITQAPYIMGLADGLMKNDIPYKLISEGNCMGYHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JH2</accession>
    <name>Q32JH2_SHIDS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerophosphatase A</fullName>
            <ecNumber evidence="1">3.1.3.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphatidylglycerolphosphate phosphatase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pgpA</name>
        <name evidence="4" type="ordered locus">SDY_0316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:33751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="3.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.27" evidence="1"/>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_000154054.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_402024.1">
        <property type="nucleotide sequence ID" value="NC_007606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q32JH2"/>
    <dbReference type="STRING" id="300267.SDY_0316"/>
    <dbReference type="EnsemblBacteria" id="ABB60535">
        <property type="protein sequence ID" value="ABB60535"/>
        <property type="gene ID" value="SDY_0316"/>
    </dbReference>
    <dbReference type="KEGG" id="sdy:SDY_0316"/>
    <dbReference type="PATRIC" id="fig|300267.13.peg.365"/>
    <dbReference type="HOGENOM" id="CLU_103734_0_1_6"/>
    <dbReference type="OMA" id="VWDEIAG"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002716">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06971">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026037">
        <property type="entry name" value="PgpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007686">
        <property type="entry name" value="YutG/PgpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36305">
        <property type="entry name" value="PTHR36305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04608">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006162">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0595">Phospholipid degradation</keyword>
    <keyword evidence="1" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PgpA" evidence="3">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB60535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002716"/>
        </source>
    </evidence>
    <sequence length="171" mass="19407" checksum="B178141A36C8B8A4" modified="2005-12-06" version="1">MTILPRHKDVAKSRLKMSNPWHLLAVGFGSGLSPIVPGTMGSLAAIPFWYMMTFLPWQLYSLVVMLGICIGVYLCHQTAKDMGVHDHGSIVWDEFIGMWITLMALPTNDWQWVAAGFVIFRILDMWKPWPIRWFDRNVHGGMGIMIDDIVAGVISAGILYFIGHHWPLDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q32JM9</accession>
    <name>Q32JM9_SHIDS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iso-IS1 ORF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SDY_0255</name>
        <name evidence="4" type="ordered locus">SDY_0260</name>
        <name evidence="5" type="ordered locus">SDY_0261</name>
        <name evidence="6" type="ordered locus">SDY_0347</name>
        <name evidence="7" type="ordered locus">SDY_0470</name>
        <name evidence="8" type="ordered locus">SDY_0617</name>
        <name evidence="9" type="ordered locus">SDY_0637</name>
        <name evidence="10" type="ordered locus">SDY_0640</name>
        <name evidence="11" type="ordered locus">SDY_0653</name>
        <name evidence="12" type="ordered locus">SDY_0766</name>
        <name evidence="13" type="ordered locus">SDY_0801</name>
        <name evidence="14" type="ordered locus">SDY_0805</name>
        <name evidence="15" type="ordered locus">SDY_1031</name>
        <name evidence="16" type="ordered locus">SDY_1036</name>
        <name evidence="17" type="ordered locus">SDY_1054</name>
        <name evidence="18" type="ordered locus">SDY_1061</name>
        <name evidence="19" type="ordered locus">SDY_1070</name>
        <name evidence="20" type="ordered locus">SDY_1081</name>
        <name evidence="21" type="ordered locus">SDY_1102</name>
        <name evidence="22" type="ordered locus">SDY_1119</name>
        <name evidence="23" type="ordered locus">SDY_1203</name>
        <name evidence="24" type="ordered locus">SDY_1238</name>
        <name evidence="25" type="ordered locus">SDY_1299</name>
        <name evidence="26" type="ordered locus">SDY_1369</name>
        <name evidence="27" type="ordered locus">SDY_1418</name>
        <name evidence="28" type="ordered locus">SDY_1446</name>
        <name evidence="29" type="ordered locus">SDY_1468</name>
        <name evidence="30" type="ordered locus">SDY_1484</name>
        <name evidence="31" type="ordered locus">SDY_1503</name>
        <name evidence="32" type="ordered locus">SDY_1512</name>
        <name evidence="33" type="ordered locus">SDY_1542</name>
        <name evidence="34" type="ordered locus">SDY_1574</name>
        <name evidence="35" type="ordered locus">SDY_1622</name>
        <name evidence="36" type="ordered locus">SDY_1635</name>
        <name evidence="37" type="ordered locus">SDY_1649</name>
        <name evidence="38" type="ordered locus">SDY_1662</name>
        <name evidence="39" type="ordered locus">SDY_1738</name>
        <name evidence="40" type="ordered locus">SDY_1815</name>
        <name evidence="41" type="ordered locus">SDY_1832</name>
        <name evidence="42" type="ordered locus">SDY_1874</name>
        <name evidence="43" type="ordered locus">SDY_1983</name>
        <name evidence="44" type="ordered locus">SDY_2002</name>
        <name evidence="45" type="ordered locus">SDY_2063</name>
        <name evidence="46" type="ordered locus">SDY_2098</name>
        <name evidence="47" type="ordered locus">SDY_2138</name>
        <name evidence="48" type="ordered locus">SDY_2141</name>
        <name evidence="49" type="ordered locus">SDY_2148</name>
        <name evidence="50" type="ordered locus">SDY_2202</name>
        <name evidence="51" type="ordered locus">SDY_2314</name>
        <name evidence="52" type="ordered locus">SDY_2402</name>
        <name evidence="53" type="ordered locus">SDY_2565</name>
        <name evidence="54" type="ordered locus">SDY_2567</name>
        <name evidence="55" type="ordered locus">SDY_2648</name>
        <name evidence="56" type="ordered locus">SDY_2660</name>
        <name evidence="57" type="ordered locus">SDY_2695</name>
        <name evidence="58" type="ordered locus">SDY_2761</name>
        <name evidence="59" type="ordered locus">SDY_2776</name>
        <name evidence="60" type="ordered locus">SDY_2797</name>
        <name evidence="61" type="ordered locus">SDY_2802</name>
        <name evidence="62" type="ordered locus">SDY_2874</name>
        <name evidence="63" type="ordered locus">SDY_2975</name>
        <name evidence="64" type="ordered locus">SDY_3229</name>
        <name evidence="65" type="ordered locus">SDY_3270</name>
        <name evidence="66" type="ordered locus">SDY_3293</name>
        <name evidence="67" type="ordered locus">SDY_3535</name>
        <name evidence="68" type="ordered locus">SDY_3546</name>
        <name evidence="69" type="ordered locus">SDY_3583</name>
        <name evidence="70" type="ordered locus">SDY_3626</name>
        <name evidence="71" type="ordered locus">SDY_4151</name>
        <name evidence="72" type="ordered locus">SDY_4190</name>
        <name evidence="73" type="ordered locus">SDY_4356</name>
        <name evidence="74" type="ordered locus">SDY_4373</name>
        <name evidence="75" type="ordered locus">SDY_4452</name>
        <name evidence="76" type="ordered locus">SDY_4473</name>
        <name evidence="77" type="ordered locus">SDY_4496</name>
        <name evidence="78" type="ordered locus">SDY_4506</name>
        <name evidence="79" type="ordered locus">SDY_4645</name>
    </gene>
    <organism evidence="3 80">
        <name type="scientific">Shigella dysenteriae serotype 1 (strain Sd197)</name>
        <dbReference type="NCBI Taxonomy" id="300267"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Gammaproteobacteria</taxon>
            <taxon>Enterobacterales</taxon>
            <taxon>Enterobacteriaceae</taxon>
            <taxon>Shigella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 80" key="1">
        <citation type="journal article" date="2005" name="Nucleic Acids Res." volume="33" first="6445" last="6458">
            <title>Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Yang J."/>
                <person name="Zhang X."/>
                <person name="Chen L."/>
                <person name="Jiang Y."/>
                <person name="Yan Y."/>
                <person name="Tang X."/>
                <person name="Wang J."/>
                <person name="Xiong Z."/>
                <person name="Dong J."/>
                <person name="Xue Y."/>
                <person name="Zhu Y."/>
                <person name="Xu X."/>
                <person name="Sun L."/>
                <person name="Chen S."/>
                <person name="Nie H."/>
                <person name="Peng J."/>
                <person name="Xu J."/>
                <person name="Wang Y."/>
                <person name="Yuan Z."/>
                <person name="Wen Y."/>
                <person name="Yao Z."/>
                <person name="Shen Y."/>
                <person name="Qiang B."/>
                <person name="Hou Y."/>
                <person name="Yu J."/>
                <person name="Jin Q."/>
            </authorList>
            <dbReference type="PubMed" id="16275786"/>
            <dbReference type="DOI" id="10.1093/nar/gki954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 80">Sd197</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Absolutely required for transposition of IS1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB60987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB61983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000034">
        <property type="protein sequence ID" value="ABB62189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ABB61942"/>
        <property type="gene ID" value="SDY_1832"/>
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        <property type="protein sequence ID" value="ABB61983"/>
        <property type="gene ID" value="SDY_1874"/>
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    <dbReference type="EnsemblBacteria" id="ABB62083">
        <property type="protein sequence ID" value="ABB62083"/>
        <property type="gene ID" value="SDY_1983"/>
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        <property type="protein sequence ID" value="ABB62097"/>
        <property type="gene ID" value="SDY_2002"/>
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        <property type="protein sequence ID" value="ABB62158"/>
        <property type="gene ID" value="SDY_2063"/>
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        <property type="protein sequence ID" value="ABB62189"/>
        <property type="gene ID" value="SDY_2098"/>
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    <dbReference type="EnsemblBacteria" id="ABB62227">
        <property type="protein sequence ID" value="ABB62227"/>
        <property type="gene ID" value="SDY_2138"/>
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        <property type="protein sequence ID" value="ABB62229"/>
        <property type="gene ID" value="SDY_2141"/>
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    <dbReference type="EnsemblBacteria" id="ABB62236">
        <property type="protein sequence ID" value="ABB62236"/>
        <property type="gene ID" value="SDY_2148"/>
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    <dbReference type="EnsemblBacteria" id="ABB62287">
        <property type="protein sequence ID" value="ABB62287"/>
        <property type="gene ID" value="SDY_2202"/>
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    <dbReference type="EnsemblBacteria" id="ABB62391">
        <property type="protein sequence ID" value="ABB62391"/>
        <property type="gene ID" value="SDY_2314"/>
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    <dbReference type="EnsemblBacteria" id="ABB62476">
        <property type="protein sequence ID" value="ABB62476"/>
        <property type="gene ID" value="SDY_2402"/>
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        <property type="protein sequence ID" value="ABB62630"/>
        <property type="gene ID" value="SDY_2565"/>
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        <property type="protein sequence ID" value="ABB62631"/>
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        <property type="protein sequence ID" value="ABB62699"/>
        <property type="gene ID" value="SDY_2648"/>
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        <property type="protein sequence ID" value="ABB62711"/>
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        <property type="protein sequence ID" value="ABB62742"/>
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        <property type="protein sequence ID" value="ABB62804"/>
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        <property type="protein sequence ID" value="ABB62819"/>
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        <property type="protein sequence ID" value="ABB62840"/>
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        <property type="protein sequence ID" value="ABB62845"/>
        <property type="gene ID" value="SDY_2802"/>
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        <property type="protein sequence ID" value="ABB62999"/>
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        <property type="protein sequence ID" value="ABB64260"/>
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        <property type="protein sequence ID" value="ABB64333"/>
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        <property type="protein sequence ID" value="ABB64349"/>
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        <property type="protein sequence ID" value="ABB64372"/>
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        <property type="protein sequence ID" value="ABB64381"/>
        <property type="gene ID" value="SDY_4506"/>
    </dbReferen